Dans la problématique de l'utilisation de nouvelles énergies non polluantes, l'hydrogène est l'un des principaux carburants verts du futur. Les dérivés d'hydrazine et de borane sont potentiellement intéressants pour le stockage chimique de l'hydrogène. Les complexes entre hydrazines ou nitriles avec des boranes ou des alanes sont à la base de cette étude. Ces composés ont été synthétisés afin d'étudier leur structure électronique avant et après la création de la liaison entre les acides et les bases de Lewis. La spectroscopie photoélectronique à rayonnement UV (UV-SPE) est utilisée comme outil principal de caractérisation fournissant des énergies d'ionisation (IE). L’interprétation des résultats expérimentaux est supportée par des calculs quantiques comme ΔSCF + TD-DFT, OVGF, P3 et SAC-CI. Des simulations et des expériences par Flash Vacuum Thermolysis (FVT) ont été effectuées, portant sur l’élimination d'hydrogène à partir de dérivés d'hydrazine borane. / Within the problematic of the use of new non-polluting energies, hydrogen is one of the main green fuels of the future. Hydrazine borane derivatives are potentially interesting chemical hydrogen storage materials. Complexes between hydrazines or nitriles with boranes or alanes are the basis of this study. These compounds were synthesized in order to study their electronic structure before and after creation of the bond between the Lewis acids and bases. Ultraviolet Photoelectron Spectroscopy (UV-PES) is used as a main characterization tool, providing Ionization Energies (IE). The interpretation of the experimental results is supported by Quantum Chemical Calculations as ΔSCF+TD-DFT, OVGF, P3 and SAC-CI methods. Simulations and experiments by Flash Vacuum Thermolysis (FVT) were carried out on hydrogen release from hydrazine borane derivatives.

nÃo hà / Esta pesquisa busca analisar os elementos utilizados por Tim Burton para representar a Era Vitoriana atravÃs do figurino, meio de transporte e decoraÃÃo. Trabalharemos tambÃm com a traduÃÃo em imagens do nonsense em sua adaptaÃÃo fÃlmica Alice in Wonderland (2010). Nessa perspectiva, o presente trabalho resulta de um estudo comparativo entre o filme e a obra na qual se baseia, o cÃnone da literatura infantil Aliceâs Adventures in Wonderland de Lewis Carroll (1865). Para tanto, faremos um cotejo entre as duas obras à luz das teorias de Elizabeth Sewell (2015), Wim Tigges, (1988) e Susan Stewart (1980) que alicerÃam o gÃnero literÃrio nonsense. LanÃaremos mÃo da versÃo literÃria Lewis Carroll: The Complete Fully Illustrated Works de 1995 da editora Gramercy, contendo toda a obra de Lewis Carroll com ilustraÃÃes originais. Isso, a fim de viabilizar e facilitar a comparaÃÃo com as figuras presentes no texto literÃrio, quando necessÃrio, para investigar se houve aproximaÃÃo na representaÃÃo visual feita pelo diretor.

Made available in DSpace on 2014-07-29T15:06:24Z (GMT). No. of bitstreams: 1 RENATO MENDES ROCHA.pdf: 735741 bytes, checksum: 6559707c78ce13d85086e58b691dd7f3 (MD5) Previous issue date: 2010-08-30 / In this dissertation we will defend Lewis Modal Realism (LMR), i.e., the metaphysical hypothesis about the real existence of a plurality of worlds. We will try to show the pragmatic character of Lewis arguments in support of this metaphysics of possible worlds. In this sense, we approximate Lewis (1986) and Quine (1960) and we aim to show that Lewis uses criteria for taking ontological decisions similar to those defended by Quine. These criteria are: simplicity of formulation, theoretical economy and distrust in purely intuitive criteria as only guide for Philosophy. To accomplish our intention, we divided the text in three chapters. In the first we present the philosophical benefits of LMR that demonstrate the theoretical utility of possible-worlds talk. These benefits are related to important concepts in Philosophy of Language and Epistemology, such as, Modality, Counterfactuals and a uniform treatment to Properties and Propositions. The second chapter is divided into two parts. At first we present the philosophical background we believe is related to Lewis philosophy. A neo-humean scenario and the resumption of metaphysics discussion in contemporary analytic philosophy compose this background. In the second part we present three fundamental thesis formulate by Lewis the consistence of his Modal Realism: concreteness, isolation and plenitude. In the third and latter chapter we discuss two criticism of LMR: (a) David Armstrong & Peter Forrest (1984) and (b) Susan Haack (1977). Each of these papers present criticism from distinct points of view. The first aims to identify a paradox in the metaphysics of possible worlds, and the latter focuses on semantics aspects of LMR. Finally, we show Lewis reply to objection (a) and that argument (b) could be inserted as an incredulous stare on LMR, and that it consists on a petition principi. / Nessa dissertação defenderemos o Realismo Modal de David Lewis (RML), ou seja, a hipótese metafísica acerca da existência real de uma pluralidade de mundos. A defesa que apresentaremos procura evidenciar o caráter pragmático dos argumentos a favor dessa metafísica dos mundos possíveis. Nesse sentido, aproximaremos a filosofia de David Lewis (1986) a de W. V. O. Quine (1960) e procuraremos mostrar que Lewis utiliza critérios para tomada de decisões ontológicas semelhantes aos defendidos por Quine. Esses critérios são: a simplicidade de formulação, a economia teórica e a desconfiança de critérios meramente intuitivos como guias para a Filosofia. Para cumprir nosso objetivo, estruturamos a dissertação em três capítulos. No primeiro apresentamos benefícios filosóficos do RML que demonstram a utilidade teórica do idioma dos mundos possíveis. Esses benefícios estão relacionados a noções importantes para a Filosofia da Linguagem e a Teoria do Conhecimento tais como: Modalidades, Contrafatuais, e um tratamento uniforme para Propriedades e Proposições. O segundo capítulo divide-se em duas partes. Na primeira traçamos um pano de fundo filosófico que acreditamos estar relacionado à filosofia de Lewis. Compõem esse pano de fundo: um cenário que identificamos como neo-humeano e a retomada de discussões metafísicas na Filosofia Analítica Contemporânea. Na segunda parte apresentamos três teses formuladas por Lewis para garantir a consistência e a coerência de seu Realismo Modal: a Concretude, o Isolamento e a Plenitude. No terceiro capítulo discutimos duas críticas ao RML: (a) David Armstrong & Peter Forrest (1984) e (b) Susan Haack (1977). Cada um desses artigos apresenta uma crítica diferente. A primeira procura identificar um paradoxo na metafísica dos mundos possíveis e a segunda concentra-se em aspectos semânticos do RML. Por fim, mostramos como a objeção em (a) é refutada por Lewis e como o argumento em (b) poderia se inserir no grupo de críticas que Lewis classifica como um olhar incrédulo sobre o RML. Por isso, concluímos que esse olhar consiste em uma petição de princípio.

O objetivo deste trabalho foi investigar o uso de NbCl5 como ácido de Lewis em reações de cicloadição. Foram estudadas algumas reações de cicloadição [2 + 2], Reações de Diels-Alder entre enonas e ciclopentadieno e Reações da aza-Diels-Alder com bases de Schiff, avaliando o efeito da temperatura e da concentração molar do NbCl5. A comparação dos rendimentos, dos produtos formados e do tempo de reação com NbCl5, também foi um ponto fundamental da pesquisa. As reações de cicloadição [2 + 2] foram realizadas entre ésteres propiólicos e diferentes tipos de alcenos (éteres enólicos de silício e alcenos alifáticos). Nas reações com os éteres enólicos de silício não foi verificada a formação dos respectivos adutos de ciclobuteno, pois o NbCl5 promove a quebra da ligação oxigênio-silício, não levando à formação do produto desejado. Nas reações com os alcenos alifáticos foi possível obter o respectivo aduto, porém com rendimentos menores que com outros ácidos de Lewis. Quanto às reações de Diels-Alder, foram investigadas as reações entre diferentes ciclo-enonas (dienófilos de baixa reatividade) com ciclopentadieno (dieno) na presença de NbCl5. Os resultados obtidos indicam que o NbCl5 é um bom ácido de Lewis para ativar reações de Diels-Alder, apresentando tempos reacionais menores e alta diastereosseletividade a temperaturas mais baixas, quando comparado com outros ácidos de Lewis. A possibilidade de efetuar reações do Diels-Alder a -78 0C é um dos aspectos de destaque neste trabalho, pois, além de demonstrar a forte ativação do sistema enona exercido pelo NbCl5, possibilita obter produtos com alta seletividade. Paralelamente aos estudos de sistemática reacional foram realizados estudos de elucidação estrutural completa de alguns dos compostos sintetizados, utilizando-se diversas técnicas de RMN (uni e bidimensionais), e o auxílio de cálculos teóricos. Nas reações de aza-Diels-Alder entre bases de Schiff e di-hidropirano, o NbCl5 se mostrou um ótimo catalisador para a síntese de derivados de piranoquinolinas. Estes derivados formam uma importante classe de produtos naturais que apresentam ampla atividade biológica. As reações foram conduzidas com baixas concentrações de nióbio e em tempos relativamente curtos, obtendo-se rendimentos variando de 72 a 96 %. Outro fator a se destacar é a alta diastereosseletividade encontrada nestas reações. Também foram realizados estudos da atividade tripanocida dos derivados de piranoquinolinas preparados através das reações de aza-Diels-Alder catalisadas por NbCl5. / The aim of this work was to investigate the use of NbCl5 as Lewis acid in cycloadittion reactions. We have studied [2 + 2] cycloaddition reactions, Diels-Alder reactions between enonas and cyclopentadiene and aza-Diels-Alder reactions with Schiff bases. The effects of the temperature and of the molar concentration of NbCl5 were also evaluated. Comparasion of reaction yields, obtained products as well as reation time with NbCl5 were also a key point on this work. The [2 + 2] cycloaddition reactions were performed using propiolic ester and different types of alkenes (silyl enol ethers and aliphatic alkenes). In the reactions with silyl enol ethers, formation of the corresponding cyclobutene aductts was not verified, since the NbCl5 promotes the rupture of oxygen-silicon bonds, and the desired product is not obtained. In the reactions with aliphatic alkenes, it was possible to obtain the adduct, however, in lower yields as compared to those obtained with others Lewis acids. Regarding the Diels-Alder reactions, we have investigated reactions using different cycloenones (dienophiles of low reactivity) with cyclopentadiene (diene) with NbCl5. The obtained results indicate that NbCl5 is a good Lewis acid to activate these Diels-Alder reactions, resulting in shorter reaction times and higher diastereoselectivity at lower temperatures than other Lewis acids. The possibility of carrying out Diels-Alder reaction at -78 0C is another remarkable aspect of this work. Besides demonstrating the strong activation of the enone system by NbCl5, it opens the possibility of obtaining high stereoselectivity. We have also performed studies of complete structural elucidation of some compounds by using different NMR techniques (uni and bidimensional), with the help of theoretical calculations. In the aza-Diels-Alder reactions between Schiff bases and dihydropyran, the NbCl5 was an excellent catalyst for the synthesis of pyranoquinoline derivatives. These derivatives are an importante class of natural products that exhibit wide range of biological activity. The reactions were carried out at low concentration of niobium and in relatively short times, resulting in yields varying from 72 to 96 %. Another aspect that should be remarked is the high diastereoselectivity found in these reactions. We have also carried out studies of tripanocydal activity of pyranoquinoline derivatives prepared through aza-Diels-Alder reactions catalyzed by NbCl5.

No presente trabalho foram realizados estudos de regiosseletividade das reações de abertura de 2,3-epoxipropanoato de etila (1) utilizando diferentes nucleófilos de selênio e algumas dessas reações foram desenvolvidas com a adição do ácido de Lewis trifluoreto de boro dietil éter (BF3·Et2O). A abertura desse oxirano ao utilizar os nucleófilos MeSeMgCl e MeSeLi-BF3·Et2O ocorreu seletivamente no Carbono C-3 formando o composto de interesse (3-metilseleno 2-hidroxipropanoato de etila), já ao utilizar MeSeLi (em ausência ácido de Lewis) a abertura procedeu-se seletivamente no carbono C-2 formando 2-metilseleno-3-hidroxipropanoato de etila. A reação com o nucleófilo (Na[PhSeB(OEt)3]) levou à mistura desses regioisômeros. O ácido de Lewis BF3·Et2O em presença do selenolato levou a inversão de regiosseletividade da reação de abertura do epóxido 1 e a razão estequiométrica de BF3·Et2O adicionada ao meio reacional correspondeu, proporcionalmente, a porcentagem de obtenção do produto de abertura em C-3 (Tabela 1). Os resultados obtidos sugeriram que BF3·Et2O altera a nucleofilicidade do selenolato (RMN de 77Se) a partir de uma interação selênio-boro. A formação da ligação Se-B pode ocorrer com ou sem a liberação de fluoreto e esse mecanismo foi investigado por meio do emprego de uma sonda fluorescente seletiva desse haleto. O mecanismo dessas reações também foram investigados por cálculos teóricos, os quais mostram-se totalmente coerentes com os resultados experimentais. / In the present work was studied reactions of regioselective opening of 2,3-epoxyester using different selenolatos and some of this reactions were developed by adding Lewis acid BF3·Et2O. The opening reaction of this oxirane using the nucleofilms MeSeMgCl and MeSeLi-BF3·Et2O occurred selectively in carbon C-3 forming the compound of interest (ethyl 3-methylselene 2-hydroxypropanoato of ethyl), already using MeSeLi (in Lewis acid absence) the reaction was selectively on C-2 carbon to form ethyl 2-methylselene-3-hydroxypropanoate. The reaction with the nucleophile (Na[PhSeB(OEt)3]) formed a mixing of these regioisomers. The Lewis acid BF3·Et2O in presence of selenolate reverses the regioselectivity of opening epoxide (1) reaction and the stoichiometric value of BF3·Et2O added in the reaction corresponded proportionally with the percentage of C-3 product (Table 1). The results suggested that BF3·Et2O alters the nucleophilicity of selenolate (77Se NMR) from a selenium-boron interaction. Se-B bond formation may occur with or without fluoride release and this mechanism has been investigated by the use of a selective fluorescent probe of that halide. The mechanism of these reactions was also investigated by theoretical calculations, which are fully consistent with the experimental results.

Le stockage et le relargage contrôlé du dihydrogène est devenu un domaine important de recherche visant à répondre à une demande énergétique grandissante. Bien que le borazane (NH3-BH3) ait été identifié comme un candidat de choix dû à sa grande capacité de stockage (16.9 wt.% H2), les chercheurs ont mis en évidence certaines limitations telles que des difficultés de mise en forme et des difficultés de régénération du matériau.Nous avons tenté de répondre à ces problématiques en concevant de nouveaux polymères contenant des fonctions de type amine-borane dans leur chaîne principale (polyboramines) et sur les chaînes latérales, afin d’étudier l’influence du squelette polymère sur les propriétés du matériau et sa réactivité associée. Nos objectifs ont visé une facilité de synthèse et de mise en forme mais aussi l'éventualité d'une régénération simple et directe du réservoir après relargage du dihydrogène. Nous avons synthétisé ces polymères en une étape quantitativement et sélectivement à partir de fragments commerciaux ou facilement accessibles. Nous avons observé une influence conséquente de la matrice polymère sur les paramètres cinétiques et thermodynamiques de la déshydrogénation, à la suite de quoi nous avons étudié les paramètres structuraux influençant la réactivité. De plus les polymères obtenus après déshydrogénation ont montré d’intéressantes propriétés mécaniques et chimiques. Ces résultats nous ont encouragés à nous pencher vers le recyclage de ces réservoirs à hydrogène / Dihydrogen storage and controlled release has become an essential area of research aspiring to answer the ever-growing energetic demand. If ammonia-borane (NH3-BH3) was early on identified as a premium candidate to constitute a H2 reservoir, due to its maximum storage capacity (16.9 wt.% H2), researchers have then identified its shortcomings such as poor processability and troublesome material recycling.We have proposed to address these issues through the synthesis of new polymers containing the amine-borane motif in the main-chain (polyboramine) or as pendant moieties, harnessing improvements brought by the polymer backbone on the reactivity and material properties. We aimed at an ease of preparation, an enhanced processability but also an access to recyclable materials via simple re-hydrogenation techniques. We have synthesized these polymers from available organic building blocks by simple treatment of diammonium and bisboronic acids with LiAlH4. We showed that the polymer matrix has a drastic effect on kinetic and thermodynamic parameters of the dehydrogenation process. We investigated the role of structural parameters on the reactivity. Moreover, polymers obtained after dehydrogenation (H2 release) still feature interesting mechanical and chemical properties. These results give us hope regarding the recycling of these hydrogen reservoirs

Coordination chemistry usually applies to transition metals, but has recently been extended to the p-block elements. For the pnictogen atoms (group 15), this type of coordination chemistry has already been applied to antimony and bismuth, where they behave as Lewis acceptor centres. However, complexes with nitrogen and phosphorus as Lewis acidic centres are rare, due to their relatively small atomic radii and inherent basic nature. Instead, these elements (Pn(III)) are typically observed as donor centres because they are better at donating their electron pair, than they are at accepting them. To enhance the Lewis acidity at the phosphorus and nitrogen centres, a cationic charge can be introduced by heterolytically abstracting a halide and replacing it with a weakly coordinating anion, providing more opportunities for new reactivity. The presence of a stereochemically active lone pair at the acceptor site also introduces new reactivity patterns to be explored. The formation of these main group coordination complexes opens doors to potential applications in catalysis, small molecule activation, or as material precursors. 2,2’-bipyridine (bipy) has been a prototypical ligand used in transition metal coordination chemistry due to its high basicity and oxidative resistance. This property has been exploited to enable a comprehensive study of a series of Pn(III) tricationic and dicationic complexes using 2,2’-bipyridine (bipy); 4,4’-di-tert-butyl-2,2’-bipyridine (tBu2bipy); 4-dimethylaminopyridine (DMAP); and other main group containing ligands. / Graduate

La cachexie est un syndrome clinique et métabolique caractérisé par une perte de tissu adipeux et de tissu musculaire, fréquemment observé chez les patients atteints de cancer. La myostatine (Mstn) régule négativement la masse musculaire. Bien que la régulation des mécanismes moléculaires impliqués dans le contrôle de la masse musculaire joue un rôle central dans la cachexie associée au cancer, les relations existant entre la Mstn et les mécanismes physiopathologiques restent largement inconnues. Suite à l’inoculation de cellules Lewis lung carcinoma (LLC) à des souris, nous avons montré que l’invalidation du gène de la Mstn (souris Mstn-/-) confère une résistance au développement de la cachexie associée au cancer par rapport à des souris sauvages. La déficience en Mstn prévient la perte de masse musculaire et réduit la croissance tumorale, 35 jours après l’injection des cellules LLC, et est associée à un allongement de la durée de vie des souris. L’invalidation du gène de la Mstn provoque aussi une augmentation de l’apoptose des cellules LLC et une diminution de l'expression de gènes impliqués dans la prolifération et le métabolisme tumoraux. L’activation des systèmes protéolytiques ubiquitine-protéasome et autophagie-lysosome, due au développement tumoral, est réduite voire supprimée dans le muscle des souris Mstn-/-. L’accumulation de céramides intramusculaires, un sphingolipide formé suite à une lipolyse exacerbée, est corrélée à la perte de masse musculaire, suggérant que les céramides pourraient être un médiateur cellulaire impliqué dans la cachexie associée au cancer. Ces résultats montrent que la Mstn joue un rôle essentiel dans la cachexie associée au cancer / Cachexia is a complex clinical and metabolic syndrome, whose definition is imprecise, characterized by an uncontrolled loss of adipose tissue and skeletal muscle mass, frequently observed in cancer patients, and leading to death in 25% of cancer patients. Myostatin (Mstn) is a negative regulator of skeletal muscle mass and a critical determinant of skeletal muscle homeostasis. Although the regulation of the molecular mechanisms involved in the control of skeletal muscle mass plays a central role in the pathogenesis of cancer cachexia, the relationships between Mstn and the pathophysiological mechanisms remain largely unknown. Following subcutaneous inoculation of Lewis lung carcinoma cells (LLC) in mice, we showed that the Mstn gene inactivation (Mstn-/- mice) confers resistance to the development of cancer cachexia, compared to wild type mice. Mstn deficiency prevents the loss of skeletal muscle mass and reduces tumor growth, 35 days after the inoculation of LLC cells, and this is associated with a longer life of mice. Mstn gene inactivation also causes an increased apoptosis of LLC cells and decreases expression of genes involved in tumor proliferation and metabolism. Activation of ubiquitin-proteasome and autophagy-lysosome proteolytic systems, triggered by tumor growth is significantly reduced or suppressed in skeletal muscle of Mstn-/- mice. Accumulation of intramuscular ceramides, a sphingolipid synthesized due to excessive lipolysis, is correlated with the loss of muscle mass, suggesting that ceramides may be a cellular mediator involved in the pathogenesis of cancer cachexia. These results show that Mstn plays a critical role in the pathogenesis of cancer cachexia

Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-01-11T09:45:38Z No. of bitstreams: 1 lucianafreesz.pdf: 7787942 bytes, checksum: 7780bae5591001ec08183042e5631936 (MD5) / Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-01-25T16:57:55Z (GMT) No. of bitstreams: 1 lucianafreesz.pdf: 7787942 bytes, checksum: 7780bae5591001ec08183042e5631936 (MD5) / Made available in DSpace on 2016-01-25T16:57:55Z (GMT). No. of bitstreams: 1 lucianafreesz.pdf: 7787942 bytes, checksum: 7780bae5591001ec08183042e5631936 (MD5) Previous issue date: 2015-04-08 / CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Esta dissertação investiga a trajetória de criação das imagens realizada entre o autor e o ilustrador nas duas narrativas escritas por Lewis Carroll, Alice no País das Maravilhas e Alice no País do Espelho. Publicadas no século XIX, ambas as obras foram ilustradas pelo ilustrador e cartunista inglês John Tenniel. Temos como objetivo reunir informações que esclareçam e facilitem a compreensão do processo de tradução do texto literário para a criação de imagens gráficas. O título “Texto e Imagem” é uma tentativa de agregar estas duas linguagens, observando, por meio do conceito de suplemento de Jacques Derrida, como ambas trabalham intrinsecamente dentro do livro ilustrado. Nas narrativas de Alice, essas linguagens seriam dependentes? Existe uma dominação ou uma exclusividade do texto verbal diante do texto visual? Seriam as imagens fundamentais para o entendimento da narrativa e, assim, o ilustrador seria também autor da obra? Para percorrer estes meandros, em primeiro lugar abordamos as narrativas de Alice em seu texto escrito e constatamos a tendência imagética de sua linguagem verbal. Em segundo lugar conceituamos e levamos em conta o que constitui uma imagem, explorando o livro ilustrado como um meio literário repleto de especificidades. Em terceiro lugar buscamos, por meio das correspondências trocadas entre autor e ilustrador, da análise das imagens e de comentários a respeito das ilustrações, explicar a construção visual do texto e mostrando a sua repercussão. Ao final, pensamos sobre o que se considera “imagem”, refletindo sobre as palavras, seu sentido e sua representação gráfica, a disposição do texto e os pequenos detalhes de formatação que costumam passar despercebidos aos olhares interpretativos dos leitores. Para desenvolver esta pesquisa utilizamos como corpus teórico autores que dialogam a respeito das particularidades entre o texto e a imagem; o livro ilustrado, as histórias em quadrinhos, a palavra-imagem, a poesia concreta e os escritos de artistas. O referencial bibliográfico expõe as teorias de Sophie Van der Linden, Maria Nikolajeva, Maria Scott, Martine Joly, Julio Plaza, Décio Pignatari, Haroldo e Augusto de Campos, Will Eisner, Scott McCloud, Umberto Eco, entre outros. Os autores Morton N. Cohen e Martin Gardner forneceram informações curiosas e dados biográficos sobre Lewis Carroll e John Tenniel. / This dissertation investigates the process of creation of images performed between the author and the illustrator in the two narratives written by Lewis Carroll, Alice in Wonderland and Though the Looking-Glass. Published in the nineteenth century, both works were illustrated by British illustrator and cartoonist John Tenniel. We intend to gather information that would clarify and facilitate the understanding the translation process of literary text into the creation of graphic images. The title "Text and Image" is an attempt to add these two languages, watching through the concept of supplement by Jacques Derrida, as both work intrinsically within the picture book. In Alice's narratives, these languages would be dependent? There is a domination or exclusivity to the verbal text on the visual text? Would be the images the key for understanding the narrative and, therefore, the illustrator is also author of the work? To go through among that complexity, first, it was necessary to approach Alice's narratives in his written text and and verify the tendency to imagery for his verbal language. Second, we conceptualize and take into account what constitutes an image, exploring the illustrated book as a literary media full of peculiarities. Third, we explore through correspondence sent between author-illustrator, the image analysis, comments about the illustrations that explain the visual construction of the text and we concluded showing its repercussions. Finally, we think about what is considered "image", reflecting on the words, their meaning and their graphical representation, text layout and development of the small details that often get overlooked by the readers. To develop this research we use authors that analyze the singularities between text and image; the book illustrated, comics, the word-image, concrete poetry and writings of artists. The theoretical framework involves the theories of Sophie Van der Linden, Maria Nikolajeva, Mary Scott, Martine Joly, Julio Plaza, Decius Pignatari, Haroldo and Augusto de Campos, Will Eisner, Scott McCloud, Umberto Eco, among others. The authors Morton N. Cohen and Martin Gardner contributed interesting information and biographical data about Lewis Carroll and John Tenniel.

No description available.