Origin of renal osteodystrophy and cardiovascular complications are multifactorial. This complications are caused by disorders of calcium - phosphate metabolism already at the beginning of patient's irreversible renal failure. The factors playing the most important part in the development o renal ostedystrophy and are hypocalcemia and increasing serum phosphate levels associated with a declining glomerulal filtration. Two main types of renal osteodystrophy can be described - high turnover bone disease and low turnover disease. High turnover forms of renal osteodystrophy are characterized by rapid bone turnover caused by abnormally high PTH levels. The two types of high turnover renal osteodystrophy are predominant hyperparathyroid bone disease, and mixed uremic osteodystrophy. Low turnover forms of renal osteodystrophy are characterized by a dramatic drop in the rate of bone remodeling, caused by oversuppression of PTH and/or by aluminum accumulation. The bones become thin and overly flexible, and bowing may occur. The two types of low turnover renal osteodystrophy are low turnover uremic osteodystrophy and aluminum-related bone disease. Patients who have end-stage renal disease with increased serum phosphate levels and calciumphosphate products are associated with an increased prevalence of ectopic...

No description available.

A dynamic shift in the ownership, management and development of the country’s mineral heritage took place after the inauguration of the new political dispensation in South Africa in 1994. This resulted in the enactment of the Mineral and Petroleum Resources Development Act (28/2002) (MPRDA) in 2002. In accordance with the MPRDA the country’s mineral and petroleum resources are the common heritage of the people of South Africa and the State acts as the custodian of these resources for the benefit of all people. In this capacity, the State may determine and levy a fee or consideration payable in respect of these resources. The Minerals and Petroleum Resources Royalty Act (28/2008) (MPRRA) was enacted on 24 November 2008 to impose a mineral royalty on the extraction of South Africa’s mineral resources to compensate the nation for the depletion of its mineral wealth. This legislation is likely to have a significant impact on the South African mining industry. The aim of this study was to review the development of this legislation to gain an understanding of the issues considered when it was developed and to identify certain aspects of the MPRRA that may require further research in order to be improved in future. The analysis consists of a qualitative comparison of the draft versions of the Mineral and Petroleum Resources Royalty Bill (MPRRB) and related commentary. The study recommends that legislators reconsider the level of royalties to be levied as well as the mechanism contained in the MPRRA to promote downstream beneficiation to ensure optimal benefits from extracting the nation’s mineral resources. Further research of these aspects could improve the South African mineral royalty regime in future. Copyright / Dissertation (MCom)--University of Pretoria, 2010. / Taxation / unrestricted

No description available.

Lithium represents one of the strategic elements for the rest of the 21st century due to its increasing demand in technological applications. Therefore, new efforts should be focused on the optimization of mineral characterization processes, which link the ore properties with its behaviour during downstream processes. These efforts should result in reducing operational risks and increasing resources utilization. The methodology presented in this study is based on the application of several classification techniques, aiming the mineral and textural characterization of two spodumene pegmatite deposits within the Keliber Lithium Project. Twelve textural classes have been proposed for the textual classification of the ore, which have been defined through the recognition of the main mineral features at macro- and micro-scale. The textural classification was performed through the application of drill core logging and scanning electron microscopy. Six classes are proposed to describe the characteristics of the spodumene ore. Six additional classes describe the main properties of the rocks surrounding the ore zone. Image analysis was implemented for the generation of mineral maps and the subsequent quantification of spodumene and Li2O within the analysed drill core images. The image segmentation process was executed in Fiji-ImageJ and is based on eight mineral classes and a set of seven feature extraction procedures. Thus, quantification of spodumene and Li2O is estimated by textural class. Hyperspectral images were used as a reference for assessing the estimations made through images analysis. A machine learning model in Weka allowed forecasting the behaviour of the twelve textural classes during spodumene flotation. This model is fed by metallurgical data from previous flotation tests and uses Random Forest classifier. The proposed methodology serves as an inexpensive but powerful approach for the complete textural characterization of the ore at Keliber Lithium Project. It provides information about: (1) mineral features at different scales, (2) spatial distribution of textures within the pegmatite body, (3) quantification of spodumene and Li2O within the drill cores and (4) processing response of each textural class. However, its application requires wide knowledge and expertise in the mineralogy of the studied deposits. / <p>Thesis Presentation.</p><p>Textural and Mineralogical Characterization of Li-pegmatite Deposit: Using Microanalytical and Image Analysis to Link Micro and Macro Properties of Spodumene in Drill Cores.  Keliber Lithium Project, Finland.</p><p></p>

A project report submitted to the Faculty of Engineering, University of the Witwatersrand, Johannesburg, in partial fulfillment of the requirements for the degree of Master of Science in Engineering. / This study addresses a principal issue associated with the small-scale mining industry in South Africa, namely mineral rights. Firstly it defines a small-scale mine and its role in the South African economy. It then examines the current mineral rights policy and the conditions under which the current mineral rights policy could be reformed in order to encourage the growth of the small-scale mining sector. Various models and proposals have been examined in an attempt to suggest the most suitable policy in terms of acquisition and distribution of mineral rights, Acquisition of mineral rights remains one of the major obstacles facing small-scale mining companies. The need to change the legal framework surrounding the acquisition of mineral rights is clearly demonstrated in this project report. Simplification of the legal framework would lead to easy access to mineral rights by both large-scale and small-scale, South African and foreign mining companies and remove the traditional complexities associated with the current South African mineral rights policy which tend to sterilise mineral rights. These complexities include subdivision of mineral rights, potential lockup of mineral rights by private companies and individuals and the State. Analysis of methods to rationalise the mineral rights policy have demonstrated that nationalisation and expropriation of mineral rights are counter productive and can not be used as vehicles for access to mineral rights. In order to strengthen the small-scale mining industry changes to the mineral rights have been proposed. A model mineral rights policy framework has been designed to promote small-scale mining. Introduction of a mineral fights tax, taking into consideration the specifics of the South African mining industry, similar to that of Swaziland of 1958 is proposed as one of the ways of discouraging the sterilisation of mineral rights. It introduces a cost element in the locking up of mineral rights by private companies and individuals. It is envisaged that when the cost of holding these mineral rights is greater than the benefits of holding the mineral rights, mineral rights holders would relinquish them thereby allowing access to these mineral rights to other interested parties. The relinquished mineral rights should revert to the State, which in tum should allocate them to qualified mining companies. Due considerations of the unique characteristics of the South African mining industry need to be taken into account when designing any mineral rights policy. Implementation of any such policy should therefore be done with the consensus of the mining industry. Access to State mineral rights is also considered vital. Whilst it is important to provide the small-scale mining sector with access to mineral rights it is recognised that the success of the sector depends many factors, mineral rights among others. A holistic approach that take into all facets of small-scale mining are included in the proposed policy framework for the development of the small-scale mining industry in South Africa. / AC2017

Objetivando-se estudar o efeito da suplementação mineral no desenvolvimento reprodutivo de bubalinos do desmame aos 24 meses de idade, utilizaram-se 110 búfalos, distribuídos em três experimentos (A, B e C), que foram criados em três propriedades (GA, GB e GC) no Estado do Pará. Os experimentos A e B foram realizados em áreas de terra firme com pastagens cultivadas (Brachiaria brizantha cv. Marandu) em manejos rotacionado e extensivo, respectivamente, com capacidade de suporte e perfil nutricional da forragem, semelhantes. O experimento C foi desenvolvido em áreas de várzea na Ilha de Marajó, com pastagens nativas constituídas, principalmente, por Panicum sp, Axonopus sp e Paspalum sp. Em todas as propriedades dividiram-se os animais em dois grupos (experimento A: GA1 e GA2, experimento B: GB1 e GB2, e experimento C: GC1 e GC2) que foram mantidos a pasto com diferentes suplementações minerais. Os animais foram pesados a cada 28 dias e receberam distintos suplementos minerais: grupos GA2 e GB2 mistura mineral, a ser testada, indicada para búfalos; grupos GA1 e GB1 - misturas minerais utilizadas rotineiramente na fazenda e recomendadas para bovinos; GC1 animais não suplementados e GC2 mistura mineral indicada para búfalos criados em áreas de várzea com águas salobras. As sobras da mistura mineral foram recolhidas semanalmente para se calcular o consumo real da mesma. A cada 56 dias as circunferências escrotais, comprimentos, larguras e espessuras dos testículos foram mensurados, como também foi avaliada a disponibilidade quali-quantitativa da forragem. Aos 22 meses de idade, 77 búfalos foram submetidos a colheitas de sêmen semanais, nos meses de maio e junho de 2005 (n = 616 amostras de sêmen), através de eletroejaculação para se analisar as características físico-morfológicas do sêmen. No plasma seminal foram, determinadas as concentrações de Ca, P, Mg, Cu, Co, Fe, Zn e Mn. Após 14 meses de estudos constatou-se que tanto os animais do grupo GA2 como os do GB2 obtiveram um maior ganho de peso médio diário (p<0,0001). O grupo GA1 consumiu uma maior (p<0,0001) quantidade de mistura mineral, enquanto que para os grupos GB1 e GB2 não houve diferença significativa. As medidas testiculares do grupo GA2 foram significativamente maiores, ao final do estudo, do que as do grupo GA1, demonstrando com isso um efeito da suplementação mineral sobre estas variáveis. Para o grupo GB2 a espessura, a largura e o volume testicular foram significativamente maiores. As demais medidas não sofreram variações significativas. No experimento C não houve variação entre o peso e o ganho de peso para ambos os grupos. Isso provavelmente esta relacionado ao baixo consumo de mistura mineral pelo grupo GC2. Essa pequena diferença do peso entre os grupos GC1 e GC2 foi acompanhada por uma diferença não significativa nas medidas testiculares dos grupos. Deduz-se que devido as altas correlações positivas entre a circunferência escrotal (CE), o peso corporal e demais medidas dos testículos, a CE possa ser utilizada para predizer o tamanho testicular. Conclui-se ainda que a suplementação mineral testada exerceu efeito positivo sobre o peso e o ganho de peso médio diário dos animais dos experimentos A e B. Evidenciou-se médias significativamente maiores para as características físicas do sêmen dos animais que receberam a suplementação mineral testada (GA2) com exceção da concentração espermática. Para as características morfológicas do ejaculado, observou-se que os animais do grupo GA1 apresentaram médias significativamente maiores para o número total de espermatozóides anormais. Não foram verificadas diferenças significativas nas características físicas e morfológicas do sêmen dos grupos GB1 e GB2, com exceção do volume do ejaculado e da motilidade progressiva que foram significativamente maiores para os animais do grupo GB2. Observaram-se correlações significativas, porém baixas, entre a CE a algumas características do ejaculado. Conclui-se, portanto que houve influência da suplementação mineral nas características físicas e morfológicas do sêmen dos animais do experimento A, com melhores resultados para o grupo GA2, que consumiram a suplementação mineral testada; constatou-se, ainda, uma tendência de uma melhor qualidade no sêmen dos animais do grupo GB2. Foi possível averiguar que não houve diferença significativa para os constituintes macro e microminerais do plasma seminal de búfalos jovens, criados em pastejo rotacionado, exceto para os níveis de manganês que foram significativamente maiores para os animais do grupo GA2. Obtiveram-se os seguintes valores para Ca (14,32 ± 6,40 mg/dl), P (3,86 ± 3,30 mg/dl), Mg (11,64 ± 7,02 mg/dl), Zn (4,23 ± 1,35 &mu;g/ml), Fe (8,23 ± 2,38 &mu;g/ml), Cu (0,17 ± 0,07 &mu;g/ml), Co (0,06 ± 0,04 &mu;g/ml) e Mn (0,08 ± &mu;0,06 g/ml) contidos no plasma seminal de búfalos criados em pastejo rotacionado. Os animais do grupo GB2 apresentaram maiores níveis de fósforo e cobalto do que os do grupo GB1, que por sua vez obtiveram maiores teores de manganês. Encontraram-se os seguintes valores Ca (12,16 ± 2,97 mg/dl), P (4,01 ± 4,46 mg/dl), Mg (11,37 ± 6,48 mg/dl), Zn (4,02 ± 1,39 &mu;g/ml), Fe (6,73 ± 1,80 &mu;g/ml), Cu (0,07 ± 0,03 &mu;g/ml), Co (0,14 ± 0,06 &mu;g/ml) e Mn (0,17 ± 0,11 &mu;g/ml) contidos no plasma seminal de búfalos criados em sistema extensivo. Muito embora alguns minerais tenham apresentado correlações significativas com algumas características do ejaculado, essas foram baixas. Portanto não se observou uma variação quali-quantitativa nas concentrações físicas e morfológicas do ejaculado de búfalos jovens criados em pastejo rotacionado e sistema extensivo, em função da concentração de minerais no plasma seminal. / To objectify the study of the effect of mineral supplementation in the reproductive development of buffaloes of wean in the 24 months of age, were used 110 buffaloes, distributed in three experiments (A, B e C) created in three farms (GA, GB e GC) in the Para State. The experiments A e B were realized in areas of firm soil with cultivated pasture (Brachiaria brizantha cv. Marandu) in rotational and extensive management, respectively, with similar capacity of support and nutritional profile of the forage. The experiment C was developed in tilled plain areas in Marajo Island, with native pasture basically formed by Panicum sp, Axonopus sp e Paspalum sp. In all farms the animals were divided in two groups (A: GA1 e GA2 experiment, B: GB1 e GB2 experiment, and C: GC1 e GC2 experiment) which were maintained in the pasture with different mineral supplements. The animals were pondered in each 28 days and received different mineral supplements: GA2 and GB2 groups mineral blend, to be tested, indicated to buffaloes; GA1 and GB1 groups mineral blend used in a regular procedure in the farm and recommended to bovines; GC1 group not supplemented animals and GC2 group mineral blend indicated to buffaloes created in tilled plain areas with salutary waters. The remaining mineral blends were collected weekly to calculate the real use of the blends. In each 56 days the scrotal circumferences, lengths and widths of the testis were measured, and was evaluated the availablebility of the quality and the quantity of the forage, as well. In the 22 month of age, 77 buffaloes were submitted to weekly semen collects, in May and June of 2005 (n = 616 semen samples), trough electroejaculation to analyze the semen physic and morphologic characteristics. In the seminal plasma were determined the Ca, P, Mg, Cu, Co, Fe, Zn e Mn concentration. After 14 months of research both animal groups (GA2 and GB2 groups) got larger diary medium weight gain (p<0,0001). The GA1 group has consumed a larger (p<0,0001) quantity of mineral blend, although to the GB1 and GB2 groups there wasnt any significative difference. The testicular measurements of GA2 group were significatively larger, at the end of the research, as the GA1 group, proving that the effects of mineral supplement on these variants. To the GB2 group the thickness, the width and the testicular volume were significatively larger. The others measurements havent significant variations. In the C experiment there wasnt any variation between the weight and gain of weight to both groups. This is probably connected to low use of mineral blend by GC2 group. This insignificant difference of the weight between GC1 and GC2 group was followed by an insignificant difference in the testicular measurements of the groups. Due to high positive correlations between the scrotal circumference (SC), the weight of the body e others measurements, deduce that the SC can be used to predict the testicular size. It can be concluded, as well, that the tested mineral supplement carried out a positive effect on the weight and the gain of diary medium weight of the animals in the experiments A and B. The research proved significant bigger mean rates to the physical characteristics of the animals semen that received the tested mineral supplement (GA2) with exception of spermatic concentration. To the morphological characteristics of semen, it observed that the GA1 animal group showed significant mean rates larger to the total number of abnormal sperm. Significant differences werent noted in the physical and morphological characteristics of the semen of GB1 and GB2 groups, with exception of the volume of the semen and of the motility progressive which were significatively larger to the animals of GB2 group. Significant, but low correlations between the SC and some characteristics of the semen were observed. Consequently, it can be concluded, there were influence of the mineral supplement in the physical and morphological characteristics of the animals semen of A experiment, with better results to GA2 group , that consumed the tested mineral supplement; a tendency of a better quality of the animals semen of the GB2 group animals. Was possible to verify there werent important difference to the macro and micro mineral constituents of the seminal plasma of young buffaloes, created in rotational pasture system, except to the levels of manganese which were significatively larger to the GA2 group animals. The next values were obtained: to Ca (14,32 ± 6,40 mg/dl), P (3,86 ± 3,30 mg/dl), Mg (11,64 ± 7,02 mg/dl), Zn (4,23 ± 1,35 &mu;g/ml), Fe (8,23 ± 2,38 &mu;g/ml), Cu (0,17 ± 0,07 &mu;g/ml), Co (0,06 ± 0,04 &mu;g/ml) e Mn (0,08 ± 0,06 &mu;g/ml) contained in the seminal plasma of the buffaloes created in rotational pasture system. The GB2 group animals introduced larger levels phosphorus and cobalt than the GB1 group, which obtained larger values of manganese. The following values were also discovered: Ca (12,16 ± 2,97 mg/dl), P (4,01 ± 4,46 mg/dl), Mg (11,37 ± 6,48 mg/dl), Zn (4,02 ± 1,39 &mu;g/ml), Fe (6,73 ± 1,80 &mu;g/ml), Cu (0,07 ± 0,03 &mu;g/ml), Co (0,14 ± 0,06 &mu;g/ml) e Mn (0,17 ± 0,11 &mu;g/ml) contained in the seminal plasma of the buffaloes created in extensive system. In spite of some minerals have presented significant correlations with some characteristics of the semen, these ones were lows. Then a variation of the quality and the quantity of physical and morphological concentrations of the semen of young buffaloes created in rotational pasture system and extensive system werent observed.

Em junho de 2013, o Governo Federal enviou ao Congresso Nacional uma proposta para o novo marco regulatória da mineração. No entanto, críticos dessa proposta alegam que, caso o aumento dos royalties da mineração pretendido pelo Governo não ocorra no bojo de uma reforma tributária mais ampla, a nova carga tributária pode inflar demasiadamente o custo de extração de alguns minérios no Brasil, prejudicando sua inserção no mercado internacional e, consequentemente, desestimulando investimentos produtivos no país. Neste sentido, o objetivo desta tese é realizar uma análise econômica sobre a compensação financeira pela exploração dos recursos minerais no âmbito do novo Código de Mineração. Através de um modelo de equilíbrio geral computável, foram simulados os potenciais impactos do aumento na carga tributária incidente sobre a indústria de mineração, considerando seus efeitos sobre a economia nacional e sobre os principais estados brasileiros produtores de minério. Os resultados encontrados apontam que, apesar da queda no investimento e na produção da indústria mineral, o aumento dos gastos públicos regionais deve aquecer as economias locais, gerando renda e elevação de preços. Entretanto, o modelo adotado na simulação não considera que mudanças na base de cálculo da CFEM podem mudar o comportamento dos mineradores e que os novos recursos da compensação podem alterar a política fiscal dos governos contemplados. Para avaliar a primeira possibilidade, foram analisados modelos teóricos que indicam que o novo arcabouço regulatório está caminhando no sentido contrário da neutralidade do arranjo tributário, o que, a princípio, não é desejável. No entanto, tendo em vista que a assimetria de informação entre investidor privado e regulador também gera perdas ao poder público, sugere-se um arranjo alternativo para a CFEM, onde ela é composta por um componente fixo e um componente ad valorem, sendo que os valores pagos em cada modalidade pelo minerador devem ser definidos no leilão que atribuirá às jazidas minerais aos investidores interessados. Por fim, foram avaliados os impactos da CFEM na política fiscal dos municípios contemplados vis-à-vis o comportamento dos municípios não contemplados. Para isso, foram estimados diversos modelos econométricos elaboradas com base em um propensity score weighting espacial. São testados os efeitos da CFEM sobre o esforço fiscal dos municípios, sobre a contratação de empregados no setor público e sobre os gastos públicos correntes das prefeituras. Os resultados encontrados apontam que, em geral, as rendas da CFEM: (i) diminuem o esforço de arrecadação próprio dos municípios; (ii) aumentam a contratação de pessoal no setor público; e (iii) provocam uma expansão dos gastos públicos correntes significativamente maior do que aquela resultante de aumentos da renda per capita dos contribuintes, o chamado efeito flypaper. Com base nestes resultados, é sugerida a adoção de um Fundo de Recursos Soberanos para a administração federal dos recursos da CFEM, sendo que os estados e municípios beneficiados seriam cotistas do fundo, mas resgatariam os recursos sob algumas regras pré-definidas / In June 2013, the Brazilian Government sent to the Congress a proposal for the new regulatory framework of the mining sector, which includes an increase in royalties paid by mining companies. Critics of this proposal argue that this increase does not occur under a broader tax reform. Therefore, the new tax can rise the extraction cost of some minerals in Brazil, hampering the integration of companies into the international market and hence discouraging productive investment in the country. The aim of this thesis is to conduct an economic analysis of the financial compensation for the exploitation of mineral resources (CFEM) under the new Mining Code. Through a general equilibrium model, it simulated the potential impact of the increased royalties on the mining industry, considering their effects on the national economy as well as on the main Brazilian mining states. Results show that despite the falling investment and production on the mining industry, the rise of regional public spending should boost local economies, generating income and higher prices. However, the model adopted in the simulation does not take into account that changes in the CFEM\'s calculation basis can affect the behavior of miners and that the new revenues can change the fiscal policy of benefiting governments. In order to assess the first possibility, theoretical models were analyzed, whose results indicate that the new Mining Code is moving away from a neutral taxation arrangement, which is not desirable. However, since the information asymmetry between investor and regulator also generates losses to the government, it is suggested a new alternative, which consists in a two-component CFEM: a fixed one and a variable one. The proportions of each component should be set by auctions in order to allocate mineral rights to interested investors. With the purpose of considering the second hypothesis, the impacts of CFEM on the fiscal policy of the municipalities were analyzed. In order to do so, several econometric models based on a spatial propensity score weighting are estimated. The effects of CFEM on the tax effort of the municipalities, on the hiring of employees by the public sector and on the current public spending of municipalities are tested. Results show that, in general, CFEM rents: (i) decrease the effort of municipalities; (ii) increase the hiring in the public sector; and (iii) cause an expansion of current public spending significantly higher than that resulting from increases in income per capita (flypaper effect). Based on these results, it is suggested the adoption of a Sovereign Resources Fund for federal administration of CFEM. States and municipalities should be shareholders of the fund, but some predefined rules to rescue resources should be observed

Thesis (M.Eng.(Mining Engineering))--University of Pretoria, 2000. / Abstract in English. Includes bibliographical references.

Submitted by MFEE Mestrado Profissional em Finanças e Economia Empresarial da EPGE (mfee@fgv.br) on 2015-02-24T19:56:53Z No. of bitstreams: 1 TESE FINAL Débora.pdf: 3098662 bytes, checksum: 2c28fd9275298b66bf5b3a7405f356d9 (MD5) / Approved for entry into archive by GILSON ROCHA MIRANDA (gilson.miranda@fgv.br) on 2015-03-25T20:32:36Z (GMT) No. of bitstreams: 1 TESE FINAL Débora.pdf: 3098662 bytes, checksum: 2c28fd9275298b66bf5b3a7405f356d9 (MD5) / Approved for entry into archive by Marcia Bacha (marcia.bacha@fgv.br) on 2015-03-26T18:30:54Z (GMT) No. of bitstreams: 1 TESE FINAL Débora.pdf: 3098662 bytes, checksum: 2c28fd9275298b66bf5b3a7405f356d9 (MD5) / Made available in DSpace on 2015-03-26T18:31:09Z (GMT). No. of bitstreams: 1 TESE FINAL Débora.pdf: 3098662 bytes, checksum: 2c28fd9275298b66bf5b3a7405f356d9 (MD5) Previous issue date: 2013-05-29 / The aim o f this study is to measure and analyze the productivity o f Brazilian mining industry as a whole and its subsectors. We first estimate multifactor productivity using the classic method proposed by Robert Solow where there was a drop in productivity in the period between 1997 and 2009. After a new estimation of productivity was made that corrects changes in the quality of the minerais extracted. It was observed that the drop in productivity in the period analyzed was even more pronounced. / O objetivo desse trabalho é medir e analisar a produtividade da indústria extrativa brasileira como um todo e seus subsetores. Primeiramente foi feita a estimação da produtividade multifatorial utilizando o método clássico proposto por Robert Solow de onde se verificou uma queda na produtividade do setor no período entre 1997 e 2009. Posteriormente foi feita uma nova estimação dessa produtividade que corrige as mudanças na qualidade dos minerais extraídos. Observou-se que a queda na produtividade, no período analisado, foi ainda mais acentuada.