The thesis evaluates the  competition law and new legislation adopted under the Digital Single Market Strategy framework and itf effect on the principle of copyright territoriality and current territorial licensing practices. The interest of consumers to access cultural content, the interest of right holders to exploit their work in exchange for renumeration and interest of distributors to secure a broader audience and high income are interests which are taken into account. The thesis discusses how the EU legislation reflects and balance these interests. The thesis also discusses the role of principle of copyright territoriality for business and financial practices in the audio-visual industry.

No description available.

Rationale: The purpose of this study is to investigate the stored stability of dilutions of neuromuscular blocking agents (NMBAs), namely cisatracurium, rocuronium, and vecuronium, for skin prick/intradermal testing. Methods: Concentrations of NMBAs were monitored by liquid chromatography-mass spectrometry (LC-MS/MS) for a period of 14 days. Dilutions of NMBAs were prepared in saline by factors of 10x, 100x, 1,000x, 10,000x, and 100,000x as sensitivity of the assay allowed. Diluted drug products were stored in a laboratory refrigerator until sampling. On sampling days, aliquots of each dilution were removed and compared to a freshly prepared set of reference dilutions. Results: The results are measured as beyond use date (BUD) defined as recovery of drug versus the reference (90-110%). Based on the LC-MS/MS data, the BUD for cisatracurium diluted to 10x and 100x is 96 hours. Higher dilutions (1,000x to100,000x) should be used immediately following preparation (within less than 24 hours). Vecuronium at 10x and 100x, also has a BUD of 96 hours, and the 1,000x dilution is stable for 24 hours. The 10,000x dilution should be used immediately. Rocuronium at 10x to 1,000x has a BUD of 48 hours, yet higher dilutions (10,000x and 100,000x) should be used immediately. Conclusions: With increasing dilution factors, the stability of these drugs in saline decreases, increasing deviation between samples and references. The most stable dilutions for each of the drugs tested were 10x and 100x. Stability of these drugs is likely compromised by hydrolysis of the ester bonds in the drug molecules.

No description available.

Helical tube bundles are usually used in the steam generator (SG) of High-Temperature Gas-Cooled Reactors (HTGRs) as the heat transfer area. The helical tube bundle is composed of multiple-layer helically coiled tubes, which are fixed by multiple sets of supporting structures. There are ideal flow paths separated by different layers of helical tubes. The velocity non-uniformity for different flow paths will affect the heat transfer tube temperature and the outlet steam temperature uniformity of different tube layers. In the shell side of the SG, turbulent cross flow over helical tube bundles are complicated and difficult to predict due to reverse pressure gradient and boundary layer separation. Due to the huge amount of computation resources consumption, there are few numerical simulation studies on the non-uniformity of cross flow over large-volume helical tube bundles.Two cases, namely the flow past a circular cylinder and cross flow over in-line tube bundles, are simulated to validate if Partially-Averaged Navier-Stokes (PANS) model is suitable for simulations of cross flow over helical tube bundles. The simulation results of k-ω SST PANS model are well agree with the average and local experimental data. Therefore, k-ω SST PANS model is used to investigate the influences of the supporting structure and helical diameter on the non-uniformity of cross flow over ideal helical tube bundles. The helix angle of helical tube bundle is neglected. The computational domain consists of 5 rows of helically coiled tubes in the streamwise direction. Periodic boundary conditions are used for the inlet and outlet to reduce the consumption of computing resources.For cross flow over helical tube bundles, there exists significant circumferential and radial velocities, which means there are secondary flows in the plane perpendicular to the streamwise direction. The radial velocity is about 16% of the streamwise velocity. Due to the presence of secondary flow, cross flow over individual tube is inclined, and the inclination direction changes at different circumferential positions. At the same circumferential position, the flow inclination direction is the same along the streamwise direction and radial direction. For helical tube bundles, the ratio of the blocking area to the flow area (blocking area ratio) of the inner, outer and middle flow paths are different. The blocking area ratio of the inner flow path is large, and the blocking area ratio of the outer flow path is small, resulting in non-uniform velocity distribution in different flow paths.Cross flow over helical tube bundles with three helical diameters (inner wall radius Ri is 0.02 m, 0.14 m and 0.26 m, respectively) are simulated. For small helical diameter tube bundle (Ri = 0.02 m), the maximum streamwise velocity non-uniformity is 16.6%. For tube bundles with middle and large helical diameters (Ri = 0.14 m and 0.26 m), the maximum streamwise velocity non-uniformity is 6.7% and 5.8%, respectively. The results show that the flow non-uniformity becomes more obvious for small helical diameter.The supporting structures results in more complex secondary flows. The secondary flows far from the supporting structures are larger than those in the region near the supporting structures. The supporting structures causes the blocking area ratio of inner, outer and middle flow paths vary with the helical diameter, and the blocking area ratio non-uniformity is larger than that without supporting structures. In the presence of supporting structures, the maximum streamwise velocity non-uniformities of small, middle and large helical diameter tube bundles are 22.0%, 8.8% and 6.3%, respectively. The effect of supporting structures on the flow non-uniformity increases as the helical diameter decreases. / Spiralformade rörknippen används vanligtvis i ånggeneratorn (SG) i gaskylda högtemperaturreaktorer (HTGR) som värmeöverföringsområde. Det spiralformade rörknippet består av flerskikts spiralformade rör, som är fixerade av flera uppsättningar stödkonstruktioner. Det finns idealiska flödesvägar åtskilda av olika lager av spiralformade rör. Hastighetsojämnheten för olika flödesvägar kommer att påverka värmeöverföringsrörets temperatur och utloppsångans temperaturlikformighet för olika rörskikt. På skalsidan av SG är turbulent tvärflöde över spiralformade rörknippen komplicerade och svåra att förutsäga på grund av omvänd tryckgradient och gränsskiktsseparation. På grund av den enorma förbrukningen av beräkningsresurser finns det få numeriska simuleringsstudier om ojämnheten i tvärflödet över spiralformade rörknippen med stora volymer.Två fall, nämligen flödet förbi en cirkulär cylinder och korsflödet över in-line rörknippen, simuleras för att validera om PANS-modellen (Partially-Averaged Navier-Stokes) är lämplig för simuleringar av tvärflöde över spiralformade rörknippen. Simuleringsresultaten för k-ω SST PANS-modellen stämmer väl överens med genomsnittliga och lokala experimentella data. Därför används k-ω SST PANS-modellen för att undersöka påverkan av stödstrukturen och spiraldiametern på ojämnheten i tvärflödet över ideala spiralformade rörknippen. Helixvinkeln för spiralformad rörbunt försummas. Beräkningsdomänen består av 5 rader spiralformade rör i strömriktningen. Periodiska randvillkor används för inlopp och utlopp för att minska förbrukningen av datorresurser.För tvärflöde över spiralformade rörknippen finns det signifikanta perifera och radiella hastigheter, vilket innebär att det finns sekundära flöden i planet vinkelrätt mot strömriktningen. Den radiella hastigheten är cirka 16 % av den strömvisa hastigheten. På grund av närvaron av sekundärt flöde lutar tvärflödet över enskilda rör och lutningsriktningen ändras vid olika omkretspositioner. Vid samma perifera position är flödesinklinationsriktningen densamma längs strömriktningen och radiell riktning. För spiralformade rörknippen är förhållandet mellan blockeringsarean och flödesarean (blockeringsareaförhållandet) för de inre, yttre och mellersta flödesvägarna olika. Blockeringsareaförhållandet för den inre flödesvägen är stort och blockeringsareaförhållandet för den yttre flödesvägen är litet, vilket resulterar i ojämn hastighetsfördelning i olika flödesvägar.Tvärflöde över spiralformade rörknippen med tre spiralformade diametrar (innerväggsradien Ri är 0,02 m, 0,14 m respektive 0,26 m) simuleras. För rörknippe med liten spiraldiameter (Ri = 0,02 m) är den maximala strömhastighetsolikformigheten 16,6 %. För rörknippen med mellersta och stora spiralformade diametrar (Ri = 0,14 m och 0,26 m) är den maximala strömhastighetsolikformigheten 6,7 % respektive 5,8 %. Resultaten visar att flödesojämnheten blir mer uppenbar för små spiralformade diametrar.De bärande strukturerna resulterar i mer komplexa sekundärflöden. Sekundärflödena långt från stödkonstruktionerna är större än de i området nära stödkonstruktionerna. De bärande strukturerna gör att blockeringsareaförhållandet för inre, yttre och mellersta flödesvägar varierar med den spiralformade diametern, och blockeringsareaförhållandets ojämnhet är större än utan stödkonstruktioner. I närvaro av stödkonstruktioner är de maximala strömhastighetsojämnheterna för små, mellersta och stora spiralformade rörknippen 22,0 %, 8,8 % respektive 6,3 %. Effekten av stödkonstruktioner på flödesojämnheten ökar när den spiralformade diametern minskar.

No / The electrophoretic mobilities of three beta-blocker drug practolol, timolol and propranolol, have been measured in electrolyte systems with mixed binary and ternary water-methanol-ethanol solvents with acetic acid/sodium acetate as buffer using capillary electrophoresis. The highest mobilities for the analytes studied have been observed in pure aqueous. the lowest values in ethanolic buffers The measured electrophoretic mobilities have been used to evaluate the accuracy of a mathematical model based on a mixture response surface method that expresses the mobility as a function of the solvent composition. Mean percentage error (MPE) has been computed considering experimental and calculated mobilities as an accuracy criterion. The obtained MPE for practolol, timolol and propranolol in the binary mixtures are between 0.9 and 2.6%, in the ternary water-methanol-ethanol solvent system the MPE was about 2.7%. The MPE values resulting from the proposed equation lie within the experimental relative standard deviation values and can he considered as an acceptable error.

Designs for deep ultraviolet (DUV) edge emitting laser diodes (LDs) based on the wurtzite III-nitride (III-N) material system are presented. A combination of proprietary and commercial advanced semiconductor LD simulation software is used to study the operation of III-N based DUV LDs theoretically. Critical factors limiting device performance are identified based on an extensive literature survey. A comprehensive design parameter space is investigated thoroughly with the help of advanced scripting capabilities. Several design strategies are proposed to eliminate the critical problems completely or partially. A DUV LD design is proposed based exclusively on AlInN active layers grown epitaxially on bulk AlN substrates because AlInN offers a promising alternative to AlGaN for the realization of LDs and LEDs operating in the DUV regime. The proposed AlInN-based design also features a tapered electron blocking layer (EBL) instead of a homogeneous one. Tapered EBLs redistribute the interfacial polarization charge volumetrically throughout the entire EBL thickness via compositional grading, and eliminate the parasitic inversion layer charge. AlGaN based DUV LD designs are explored also because at present, it may be difficult to grow AlInN epitaxially with superior crystalline quality. Polarization charge matching is proposed to improve electron and hole wavefunction overlap within the active region. Although the strategy of polarization charge matching has already been proposed in the literature to enhance performance of visible wavelength LEDs and LDs, the proposed design presents the first demonstration that polarization charge matching is also feasible for DUV LDs operating at sub-300 nm wavelengths. A lateral current injection (LCI) LD design is proposed featuring polarization-charge-matched barriers and regrown Ohmic contacts to avoid a group of issues related to the highly inefficient p-type doping of wide bandgap III-N materials in vertical injection designs. The proposed design partially decouples the problem of electrical injection from that of optical confinement. Although the idea of an LCI LD design has been proposed in the literature in the 90s to be used as longer wavelength active sources in optoelectronic integrated circuits using GaInAsP/InP and related material systems, the proposed design is the first theoretical demonstration that this concept can be applied to DUV LDs based on III-N material system. To solve the problem of hole transport in vertical injection designs, a DUV LD design based exclusively on AlGaN material system is presented, featuring an inverse-tapered p-waveguide layer instead of an EBL. Several EBL designs are investigated, and compared with conventionally-tapered EBL design. Through judicious volumetric redistribution of fixed negative polarization charge, inverse tapering may be exploited to achieve nearly flat valence band profiles free from barriers to hole injection into the active region, in contrast to conventional designs. Numerical simulations demonstrate that the inverse tapered strategy is a viable solution for efficient hole injection in vertical injection DUV LDs operating at shorter wavelengths (< 290 nm).

Given the current state of input/output (I/O) and storage devices in petascale systems, incremental solutions would be ineffective when implemented in exascale environments. According to the "The International Exascale Software Roadmap", by Dongarra, et al. existing I/O architectures are not sufficiently scalable, especially because current shared file systems have limitations when used in large-scale environments. These limitations are: Bandwidth does not scale economically to large-scale systems, I/O traffic on the high speed network can impact on and be influenced by other unrelated jobs, and I/O traffic on the storage server can impact on and be influenced by other unrelated jobs. Future applications on exascale computers will require I/O bandwidth proportional to their computational capabilities. To avoid these limitations C. Filippidis, C. Markou, and Y. Cotronis proposed the IKAROS framework. In this thesis project, the capabilities of the publicly available elastic-transfer (eT) module which was directly derived from the IKAROS, will be expanded. The eT uses Google’s Gmail service as an utility for efficient meta-data management. Gmail is based on the IMAP protocol, and the existing version of the eT framework implements the Internet Message Access Protocol (IMAP) client-server connection through the ‘‘Inbox’’ module from the Node Package Manager (NPM) of the Node.js programming language. This module was used as a proof of concept, but in a production environment this implementation undermines the system’s scalability and there is an inefficient allocation of the system’s resources when a large number of concurrent requests arrive at the eT′s meta-data server (MDS) at the same time. This thesis solves this problem by adopting an asynchronous non-blocking event driven approach to implement the IMAP client-server connection. This was done by integrating and modifying the ‘‘Imap’’ NPM module from the NPM repository to suit the eT framework. Additionally, since the JavaScript Object Notation (JSON) format has become one of the most widespread data-interchange formats, eT′s meta-data scheme is appropriately modified to make the system’s meta-data easily parsed as JSON objects. This feature creates a framework with wider compatibility and interoperability with external systems. The evaluation and operational behavior of the new module was tested through a set of data transfer experiments over a wide area network environment. These experiments were performed to ensure that the changes in the system’s architecture did not affected its performance. / Givet det nuvarande läget för input/output (I/O) och lagringsenheter för system i peta-skala, skulle inkrementella lösningar bli ineffektiva om de implementerades i exa-skalamiljöer. Enligt ”The International Exascale Software Roadmap”, av Dongarra et al., är nuvarande I/O-arkitekturer inte tillräckligt skalbara, särskilt eftersom nuvarande delade filsystem har begränsningar när de används i storskaliga miljöer. Dessa begränsningar är: Bandbredd skalar inte på ett ekonomiskt sätt i storskaliga system, I/O-trafik på höghastighetsnätverk kan ha påverkan på och blir påverkad av andra orelaterade jobb, och I/O-trafik på lagringsservern kan ha påverkan på och bli påverkad av andra orelaterade jobb. Framtida applikationer på exa-skaladatorer kommer kräva I/O-bandbredd proportionellt till deras beräkningskapacitet. För att undvika dessa begränsningar föreslog C. Filippidis, C. Markou och Y. Cotronis ramverket IKAROS. I detta examensarbete utökas funktionaliteten hos den publikt tillgängliga modulen elastic-transfer (eT) som framtagits utifrån IKAROS. Den befintliga versionen av eT-ramverket implementerar Internet Message Access Protocol (IMAP) klient-serverkommunikation genom modulen ”Inbox” från Node Package Manager (NPM) ur Node.js programmeringsspråk. Denna modul användes som ett koncepttest, men i en verklig miljö så underminerar denna implementation systemets skalbarhet när ett stort antal värdar ansluter till systemet. Varje klient begär individuellt information relaterad till systemets metadata från IMAP-servern, vilket leder till en ineffektiv allokering av systemets resurser när ett stort antal värdar är samtidigt anslutna till eT-ramverket. Denna uppsats löser problemet genom att använda ett asynkront, icke-blockerande och händelsedrivet tillvägagångssätt för att implementera en IMAP klient-serveranslutning. Detta görs genom att integrera och modifiera NPM:s ”Imap”-modul, tagen från NPM:s katalog, så att den passar eT-ramverket. Eftersom formatet JavaScript Object Notation (JSON) har blivit ett av de mest spridda formaten för datautbyte så modifieras även eT:s metadata-struktur för att göra systemets metadata enkelt att omvandla till JSON-objekt. Denna funktionalitet ger ett bredare kompatibilitet och interoperabilitet med externa system. Utvärdering och tester av den nya modulens operationella beteende utfördes genom en serie dataöverföringsexperiment i en wide area network-miljö. Dessa experiment genomfördes för att få bekräftat att förändringarna i systemets arkitektur inte påverkade dess prestanda.

No / A review is carried out on the characterisation and algorithmic implementation of an extended product-form approximation, based on the principle of maximum entropy (ME), for a wide class of arbitrary finite capacity open queueing network models (QNMs) with service and space priorities. A single server finite capacity GE/GE/1/N queue with R (R>1) distinct priority classes, compound Poisson arrival processes (CPPs) with geometrically distributed batches and generalised exponential (GE) service times is analysed via entropy maximisation, subject to suitable GE-type queueing theoretic constraints, under preemptive resume (PR) and head-of-line (HOL) scheduling rules combined with complete buffer sharing (CBS) and partial buffer sharing (PBS) management schemes stipulating a sequence of buffer thresholds {N=(N1,¿,NR),0<Ni¿Ni¿1,i=2,¿,R}. The GE/GE/1/N queue is utilised, in conjunction with GE-type first two moment flow approximation formulae, as a cost-effective building block towards the establishment of a generic ME queue-by-queue decomposition algorithm for arbitrary open QNMs with space and service priorities under repetitive service blocking with random destination (RS-RD). Typical numerical results are included to illustrate the credibility of the ME algorithm against simulation for various network topologies and define experimentally pessimistic GE-type performance bounds. Remarks on the extensions of the ME algorithm to other types of blocking mechanisms, such as repetitive service blocking with fixed destination (RS-FD) and blocking-after-service (BAS), are included.

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