In this thesis, a number of mathematical models of haptotactic cell migration are developed. The modelling of haptotaxis is presented in two distinct parts - the first comprises an investigation of haptotaxis in pre-necrotic avascular tumours, while the second consists of the modelling of adhesion-mediated haptotactic cell migration within tissue, with particular attention paid to the biological appropriateness of the description of cell-extracellular matrix adhesion. A model is developed that describes the effects of passive and haptotactic migration on the cellular dynamics and growth of pre-necrotic avascular tumours. The model includes a description of the extracellular matrix and its effect on cell migration. Questions are posed as to which cell types act as a source of the extracellular matrix, and the model is used to simulate the possible effects of different matrix sources. Simulations in one-dimensional and spherically symmetric geometry are presented, displaying familiar results such as three-phase tumour growth and tumours comprising a rim of proliferating cells surrounding a non-proliferating region. Novel effects are also described such as cell population splitting and tumour shrinkage due to haptotaxis and appropriate extracellular matrix construction. The avascular tumour model is then extended to describe the internalisation of labelled cells and inert microspheres within multicell tumour spheroids. A novel model of adhesion-receptor mediated haptotactic cell migration is presented and specific applications of the model to tumour invasion processes are discussed. This model includes a more biologically realistic description of cell adhesion than has been considered in previous models of cell population haptotaxis. Through assumptions of fast kinetics, the model is simplified with the identification of relationships between the simplified model and previous models of haptotaxis. Further simpli.cations to the model are made and travelling wave solutions of the original model are then investigated. It is noted that the generic numerical solution routine NAG D03PCF is not always appropriate for the solution of the model, and can produce oscillatory and inaccurate solutions. For this reason, a control volume numerical solver with .ux limiting is developed to provide a better method of solving the cell migration models.

Thesis submitted in fulfilment of the requirements for the degree Master of Technology: Electrical Engineering in the Faculty of Engineering at the Cape Peninsula University of Technology Supervisor: Prof. R. Tzoneva Co-supervisor: Prof. P. Petev 2013 / Busbars are the most important components in the distribution networks. Faults on the busbar are uncommon, however an occurrence of a busbar fault can lead to a major loss of power. Busbars are the areas in a substation where the levels of current are high and therefore the protective relay application is very critical. In order for the protection scheme to be successful it is important to carry out the following specifications: Selectivity, Stability, Sensitivity, and Speed. To meet all of the above requirements protection must be reliable, meaning that the protection scheme must trip when called up to do so (dependability) and it must not trip when it’s not supposed to (security). The thesis focuses on the reverse blocking busbar protection scheme with aim to improve the speed of its operation and at the same time to increase operational reliability, flexibility and stability of the protection during external and internal faults by implementation of the extended functionality provided by the IEC61850 standard-based protective IEDs. The practical implementation of the scheme by the use of IEC 61850 standard communication protocol is investigated. The research analyzes in detail the reverse blocking busbar protection scheme that is used at the moment in the power systems and it develops an improved IEC 61850 based reverse blocking busbar protection scheme for a distribution network. The proposed scheme is designed for a radial type of a distribution network and is modeled and simulated in the DigSILENT software environment for various faults on the busbar and its outgoing feeders. The results from the simulations are used further for implementation of the designed protection scheme. A laboratory test bench is build using three compliant with the IEC 61850 standard ABB IEDs 670 series, CMC 356 Omicron test injection device, PC, MOXA switch, and a DC power supplier. Two ways of the reverse blocking signals between the IEDs implementation are considered: hard wired and Ethernet communication by using IEC 61850 standard GOOSE messages. Comparative experimental study of the operational trip response speed of the two implementation shows that the performance of the protection scheme for the case of Ethernet communication is better The thesis findings and deliverables will be used for postgraduate studies of other students, research, short courses, and solution of industrial problems. Keywords: Busbar, Power system, reverse busbar blocking scheme; IEC61850; Distribution, Protection relays, IEDs, GOOSE message, laboratory test bench

In this work, thin and compact films of TiO2, Nb2O5 and WO3 nanoparticles were prepared to be used as contact/blocking layer in dye sensitized solar cells (DSCs). The films were produced by deposition of 30 bilayers of TiO2(ac)/TiO2(bas), TiO2(ac)/Nb2O5(bas) and TiO2(ac)/WO3(bas) using the layer-by-layer technique (LbL) from nanoparticle sols of TiO2 (pH = 2 and 10), Nb2O5 (pH = 10) and WO3 (pH 10) prepared by sol-gel method. The TiO2/TiO2 and TiO2/Nb2O5 underlayers resulted in an increase of 25% and 87% respectively, in the efficiency of DSCs when compared to those without the contact/blocking layers. The application of TiO2/WO3 films did not result in any improvement of DSC efficiency. Factors such as thickness, nanoparticles homogeneity, oxides concentration on the films and roughness directly influence on the efficiency of such films as contact/blocking layer. Field Emission Scanning Electron Microscopy (FESEM) and Atomic Force Microscopy (AFM) images, confirmed that all films are constituted by spherical nanoparticles with homogeneous diameters smaller than 20 nm, resulting on compact and low porous surfaces. This morphology ensures a physical barrier between the electrolyte and the conductive glass used as electrode in DSCs. The TiO2/TiO2 and TiO2/Nb2O5 films also exhibited higher roughness than the surface of the conductive glass without the bilayers, which increases the interaction with the mesoporous TiO2 film. The molar ratios of the species present on the films are controlled by the pH employed during deposition, and were determined by X- ray photoelectron spectroscopy (XPS). The Ti4+/Nb5+ and Ti4+/W6+ ratios were 1.6 and 19 respectively, which evidences a higher concentration of TiO2 nanoparticles on the films. For a better understanding of the role of the bilayers on the charge transfer processes, the substrates were analyzed by Electrochemical Impedance Spectroscopy (EIS). The electronic properties of the oxides also influence the efficiency of the LbL films as contact/blocking layers. Due to its higher band gap, Nb2O5 nanoparticles impose an electronic barrier to the electrons transfer from the conductive substrate to the electrolyte, additionally to the physical barrier. / Neste trabalho foram preparados filmes finos e compactos de óxidos nanoparticulados de TiO2, Nb2O5 e WO3 para a aplicação como camada de contato/bloqueio em células solares sensibilizadas por corante (DSCs). Os filmes foram produzidos pela deposição de 30 bicamadas de TiO2(ác)/TiO2(bás), TiO2(ác/Nb2O5(bás) e TiO2(ác)/WO3(bás) utilizando a técnica de automontagem (Layer-by-Layer ou LbL), a partir dos sóis nanoparticulados de TiO2 (pH = 2 e 10), Nb2O5 (pH = 10) e WO3 (pH = 10) sintetizados pelo método sol-gel. A presença das bicamadas de TiO2/TiO2, TiO2/Nb2O5 gerou aumentos relativos na eficiência das DSCs de 25% e 87% respectivamente, quando comparadas às DSCs sem as bicamadas. Já o filme de TiO2/WO3 não gerou nenhuma melhoria na eficiência das DSCs. Fatores como a espessura, homogeneidade das nanopartículas, concentração dos óxidos nos filmes e a rugosidade influenciam diretamente na eficiência dos filmes como camada de contato/bloqueio. Imagens de Microscopia Eletrônica de Varredura com Emissão de Campo (MEV-FEG) e Microscopia de Força Atômica (MFA) confirmaram que todos os filmes apresentaram nanopartículas esféricas com diâmetros homogêneos e menores que 20 nm, o que acarreta na formação de superfícies compactas e pouco porosas. Esta morfologia garante uma barreira física entre o eletrólito e a superfície do vidro condutor utilizado como eletrodo nas DSCs. Os filmes de TiO2/TiO2 e TiO2/Nb2O5 apresentaram também rugosidades maiores que a da superfície do vidro condutor sem as bicamadas, o que aumenta a interação entre com o filme de TiO2 mesoporoso. As razões molares das espécies presentes nos filmes são controladas pelo pH empregado durante as deposições, e foram determinadas por Espectroscopia de Fotoelétrons Excitados por raios-X (XPS). As razões Ti4+/Nb5+ e Ti4+/W6+ foram de 1,6 e 19 respectivamente, o que evidencia uma maior quantidade de nanopartículas de TiO2 nos filmes. Para melhor entender o papel das bicamadas nos processos de transferência de cargas, os substratos foram analisados por Espectroscopia de Impedância Eletroquímica (EIE). As propriedades eletrônicas dos óxidos também influenciam na eficiência dos filmes automontados como camada de contato/bloqueio. Devido ao seu maior valor de band gap, as nanopartículas de Nb2O5 impõem, além de uma barreira física, uma barreira eletrônica para a transferência dos elétrons do substrato condutor para o eletrólito. / Mestre em Química

IEEE 802.11 wireless LANs operating in the infrastructure mode are extremely popular and have seen widespread deployment because of their convenience and cost efficiency. A large number of research studies have investigated the performance of DCF, the default MAC protocol in 802.11 WLANs. Previous studies have pointed out several performance problems caused by the interaction of DCF in infrastructure-based WLANs. This thesis addresses a few of these issues. In the first part of the thesis, we address the issue of head-of-line (HOL) blocking at the Access Point (AP) in infrastructure WLANs. We use a cooperative ARQ scheme to resolve the obstruction at the AP queue. We analytically study the performance of our scheme in a single cell IEEE 802.11 infrastructure WLAN under a TCP controlled file download scenario and validate our analysis by extensive simulations. Both analysis and simulation results show considerable increase in system throughput with the cooperative ARQ scheme. We further examine the delay performance of the ARQ scheme in the presence of both elastic TCP traffic and delay sensitive VoIP traffic. Simulations results show that our scheme decreases the delay in the downlink for VoIP packets significantly while simultaneously providing considerable gains in the TCP download throughput. Next, we propose a joint uplink/downlink opportunistic scheduling scheme for maximising system throughput in infrastructure WLANs. We first solve the uplink/downlink unfairness that exists in infrastructure WLANs by maintaining a separate queue and a backoff timer at the AP for each mobile station (STA). We also increase the system throughput by making the backoff timer a function of the channel gains. We analyse the I performance of our scheme under symmetric UDP traffic with i. i. d. channel conditions. Finally, we discuss several opportunistic scheduling policies which aim to increase the system throughput while satisfying certain Quality of Service (QoS) objectives. The standard IEEE 802.11 DCF protocol only offers best-effort services and does not provide any QoS guarantees. Providing QoS in 802.11 networks with time varying channel conditions has proven to be a challenge. We show by simulations that by an appropriate choice of the scheduling metric in our opportunistic scheduling scheme, different QOS objectives like maximizing weighted system sum throughput, minimum rate guarantees and throughput optimality can be attained.

In this thesis we provide a model for a bufferless optical burst switching (OBS) and an optical packet switching (OPS) network. The thesis is divided in three parts. <p><p>In the first part we introduce the basic functionality and structure of OBS and OPS networks. We identify the blocking probability as the main performance parameter of interest. <p><p>In the second part we study the statistical properties of the traffic that will likely run through these networks. We use for this purpose a set of traffic traces obtained from the Universidad Politécnica de Catalunya. Our conclusion is that traffic entering the optical domain in future OBS/OPS networks will be long-range dependent (LRD). <p><p>In the third part we present the model for bufferless OBS/OPS networks. This model takes into account the results from the second part of the thesis concerning the LRD nature of traffic. It also takes into account specific issues concerning the functionality of a typical bufferless packet-switching network. The resulting model presents scalability problems, so we propose an approximative method to compute the blocking probability from it. We empirically evaluate the accuracy of this method, as well as its scalability. / Doctorat en Sciences de l'ingénieur / info:eu-repo/semantics/nonPublished

This thesis treats of QoS (Quality of Service) in UMTS system. The term quality of service is frequently used, recently, however not only in computer networks, but also more and more in mobile networks also. Present system of 2nd generation (2G) GSM enables only limited exploitation of QoS function. System UMTS is a system of 3rd generation (3G) already and contains quality of service in greater measure which is ensured with number of algorithms and functions. Individual QoS functions enable effective utilization of radio interface, support maintenance of planned coverage and offer high spectral efficiency. Functions that cater to quality of service are called RRM functions (Radio Resource Management). There exist five basic functions in UMTS system that are Admission control (AC), Power control (PC), Load control (LC), Handover control (HC) and Packet scheduler (PS). These functions are responsible for control of network access, control of power, control of network load, control of handover and packet (bit rate) scheduling. Last three functions are usually collectively designated as Congestion control, control of network overload. UMTS layer model, differentiation of services, traffic classes and 3GPP concept are also discussed. In thesis the attention is piad to Admission control algorithm – control of network access – in the uplink direction and to different ways of load (in the cell) modeling. Individual approaches are simulated in MATLAB. A possibility of using algorithm in the real system is discussed in conclusion.

Heart rate changes mediate the embryotoxic effect of antiarrhythmic drugs in the chick embryo A significant increase in cardiovascular medication use during pregnancy has occurred in recent years but only limited evidence on its safety profile is available. We hypothesized that drug-induced bradycardia is the leading mechanism of developmental toxicity. We tested metoprolol, carvedilol, or ivabradine for embryotoxicity and their acute effect on chick embryonic model. We used video microscopy and ultrasound biomicroscopy. Significant dose-dependent mortality was achieved in embryos injected with carvedilol and ivabradine. In ED4 embryos, metoprolol, carvedilol and ivabradine reduced the heart rate by 33%, 27%, and 55%, respectively, compared to controls (6%). In ED8 embryos this effect was more pronounced with a heart rate reduction by 71%, 54%, 53%, respectively (controls 36%). Cardiac output decreased in all tested groups but only proved significant in the metoprolol group in ED8 embryos. The number of -adrenergic receptors showed a downward tendency during embryonic development but a negative chronotropic effect of tested drugs was increasingly pronounced with embryonic maturity. This effect was associated with reduced cardiac output in chick embryos, probably leading to premature death....

Heart rate changes mediate the embryotoxic effect of antiarrhythmic drugs in the chick embryo A significant increase in cardiovascular medication use during pregnancy has occurred in recent years but only limited evidence on its safety profile is available. We hypothesized that drug-induced bradycardia is the leading mechanism of developmental toxicity. We tested metoprolol, carvedilol, or ivabradine for embryotoxicity and their acute effect on chick embryonic model. We used video microscopy and ultrasound biomicroscopy. Significant dose-dependent mortality was achieved in embryos injected with carvedilol and ivabradine. In ED4 embryos, metoprolol, carvedilol and ivabradine reduced the heart rate by 33%, 27%, and 55%, respectively, compared to controls (6%). In ED8 embryos this effect was more pronounced with a heart rate reduction by 71%, 54%, 53%, respectively (controls 36%). Cardiac output decreased in all tested groups but only proved significant in the metoprolol group in ED8 embryos. The number of -adrenergic receptors showed a downward tendency during embryonic development but a negative chronotropic effect of tested drugs was increasingly pronounced with embryonic maturity. This effect was associated with reduced cardiac output in chick embryos, probably leading to premature death....

When you are browsing websites, third-party resources record your online habits; such tracking can be considered an invasion of privacy. It was previously unknown how many third-party resources, trackers and tracker companies are present in the different classes of websites chosen: globally popular websites, random samples of .se/.dk/.com/.net domains and curated lists of websites of public interest in Sweden. The in-browser HTTP/HTTPS traffic was recorded while downloading over 150,000 websites, allowing comparison of HTTPS adaption and third-party tracking within and across the different classes of websites. The data shows that known third-party resources including known trackers are present on over 90% of most classes, that third-party hosted content such as video, scripts and fonts make up a large portion of the known trackers seen on a typical website and that tracking is just as prevalent on secure as insecure sites. Observations include that Google is the most widespread tracker organization by far, that content is being served by known trackers may suggest that trackers are moving to providing services to the end user to avoid being blocked by privacy tools and ad blockers, and that the small difference in tracking between using HTTP and HTTPS connections may suggest that users are given a false sense of privacy when using HTTPS. / <p>Source code, datasets, and a video recording of the presentation is available on the master's thesis website.</p>

[ES] Esta tesis se centra en la animación 3D y de forma más concreta, en la animación de personajes para un plano de actuación en un largometraje CGI. La animación ocupa un lugar importante dentro del mundo del entretenimiento desde principios del siglo XX hasta ahora; sobre todo en estas últimas décadas, donde su presencia en cortometrajes, anuncios publicitarios, videojuegos, series de televisión y películas, ha llenado nuestras salas de cines y nuestros hogares con una gran variedad de historias, personajes fantásticos y símbolos gráficos que forman parte de nuestra cultura popular más arraigada. Como animador 3D, trabajas y creces como profesional de un proyecto a otro, pero no te planteas cuánto sabes. Únicamente estás preocupado en hacer tu trabajo lo mejor posible y destacar. Cuando empecé a compaginar mi parte profesional con la docencia me di cuenta de que no era capaz de explicar al alumnado cómo aprender animación de una forma adecuada; porque una cosa es animar muy bien, pero otra muy distinta es saber explicar cómo lo haces. Está investigación me planteó el reto de recopilar todos esos conocimientos que he ido adquiriendo a través de libros, documentales, profesorado o compañeros de trabajo, y organizarlos de tal forma que fueran de fácil compresión y accesibilidad para cualquier persona que quisiera aprender animación o mejorar como animador 3D. / [CA] Aquesta tesi es centra en l'animació 3D i de forma més concreta, en l'animació de personatges per fer un pla d'actuació en un llargmetratge CGI. L'animació ocupa un lloc important dins del món de l'entreteniment des de principis del segle XX fins ara; sobretot en aquestes últimes dècades, on la seua presència en curtmetratges, anuncis publicitaris, videojocs, sèries de televisió i pel·lícules, ha omplit les nostres sales de cinemes i les nostres llars amb una gran varietat d'històries, personatges fantàstics i símbols gràfics que formen part de la nostra cultura popular més arrelada. Com a animador 3D, treballes i creixes com a professional d'un projecte a un altre, però no et planteges quant en saps. Únicament estàs preocupat per fer el teu treball tan bé com siga possible i destacar. Quan vaig començar a compaginar la meua part professional amb la docència em vaig adonar que no era capaç d'explicar al alumnat com aprendre animació d'una forma adequada; ja que una cosa és animar molt bé, però d'altra molt diferent és saber explicar com ho fas. Aquesta investigació em va plantejar el repte de recopilar tots aqueixos coneixements que he anat adquirint a través de llibres, documentals, professorat o col·legues de treball, i organitzar-los de tal forma que foren de fàcil compressió i accessibilitat per a qualsevol persona que volguera aprendre animació o millorar com a animador 3D. / [EN] This thesis focuses on 3D animation and more specifically, on the animation of characters for an acting shot in a CGI feature film. Animation has taken an important place in the world of entertainment from the beginning of the 20th century until now; especially in recent decades, where its presence in short films, commercials, video games, TV series and movies has filled our cinemas and our homes with a wide variety of stories, fantastic characters and graphic symbols that are part of our deep-rooted popular culture. As a 3D animator, you work and grow from one project to the next as a professional, but you don't think about how much you know. You are only concerned about doing your work the best you can and standing out in your field. When I started to balance my professional career with teaching I realised that I was not able to explain to my students how to learn animation in a proper way; because it is not the same thing to animate very well than explaining how to do so. This research posed the challenge of compiling all the knowledge I had acquired through books, documentaries, teachers and colleagues, and organising it in such a way that it would be easy to understand and accessible to anyone who wanted to learn animation or improve as a 3D animator. / Sanz Mariscal, A. (2023). El proceso de animación de personajes en los largometrajes 3D contemporáneos [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/195345