This thesis deals with the analysis of solar cells by photoluminescence method. Photoluminescence method is based on the excitation of luminescence radiation of the solar cell material by an external excitation light source. This method can detect various types of defects in the material solar cells. The main objective is the design and realization of a measuring system defects of solar cells, which is based on this method. For excitation of luminescence is used LED array. For the detection of luminescence is used CCD camera with IR optical filter. To filter out the excitation light radiation is used disc screen and optical interrupter. The parameters and options of this measuring system are verified and characterized by test measuring for example the achievable rotation speed of screen and response of optical interrupter. At the end is tested detection of luminescence radiation of solar cells in the measuring system. The measured images are compared with the method of electroluminescence.

The aim of this master’s thesis is to investigate the electrical properties of various thick-film resistor pastes in a wider temperature range. The thesis mainly focuses on a change in electrical resistance depending on temperatures, which extend to the cryogenic region. To achieve this, there is an overview of the thick-film technology properties, major technological procedures, principles of resistive pastes conductivity, methods of electrical resistance measuring, possible errors in measurement and methods of their minimization. The content of this work is also familiar with the characteristics of a cryogenic station, on this foundation was proposed the measurement procedure and created thick-film circuits for this station. After measurement in the interval 10 K to 350 K, there are subsequently evaluated the data and explains the principles of the conductivity of used pastes.

The work deals with the possibilities of using fine crushed and quarried aggregate to base layers of roads. The introduction of the theoretical part explains the origin of this type of aggregate. There are also described the tests, which were used to verify the attributes and features of these mixtures and their use in cemented base layers of roads. In a brief way, the work also deals with foreign research and the possibilities that arise from it. In the practical part is then described the process of mixture preparing and laboratory tests carried out on them, the production of test specimens, load tests of these specimens and interpretation of the results. The conclusion summarizes the findings. Here are also discussed ways to apply them in practice.

Konceptet open banking i EU är resultatet av införandet av det andra betaltjänstdirektivet och de kompletterande tekniska standarderna för sträng kundautentisering och säker kommunikation. Regelverket syftar till att upprätta en harmoniserad betaltjänstmarknad som balanseras mellan en hög nivå av säkerhet och en generös åtkomst till kunddata, för att främja innovation och konkurrens. I framställningen som görs i uppsatsen presenteras marknadens utveckling, de huvudsakliga aktörerna, den tidigare betaltjänstregleringen, samt motiven bakom och syftena med den nya regleringen. Genom att ge tredjepartsleverantörer direkt åtkomst till kontoinstitutens kontosystem förändras betaltjänstmarknaden i grunden. Det redogörs även för hur betaltjänstmarknaden har, och framöver sannolikt kommer att, förändras till följd av kravet på införandet av öppna API:er, men även hur konsekvenserna förhåller sig till de uttalade syftena. Regleringen har goda möjligheter att få ämnad effekt, men det faktum att ansvaret för harmoniseringen till stor del har överlämnats till marknadens aktörer är problematiskt. Det är i huvudsak två områden som är centrala; harmoniseringen av öppna API:er och förbudet mot datahämtningsmetoden screen scraping. I uppsatsen riktas kritik mot avsaknaden av lagstiftade gemensamma standarder för API:er och den förskjutning av ansvaret som har skett från lagstiftaren till marknadens aktörer. En brist som potentiellt skulle kunna leda till en fragmenterad betaltjänstmarknad. Det klargörs även att det traditionella användandet av screen scraping nu inte är tillåtet eftersom förfarandet inte uppfyller de krav som ställs på datainhämtning i RTS:en. Övergången till öppna API:er innebär en stor förändring för alla aktörer. Det återstår ännu en viss osäkerhet avseende harmoniseringen och implementeringen av öppna API:er, samt hur bestämmelserna och dess effekter förhåller sig till regelverkets syften. I uppsatsen presenteras en potentiell lösning på harmoniseringsproblematiken i form av de långt gångna och till stora delar anammade standardiseringsinitiativen som har utvecklats av marknaden. Det är framledes av största vikt att de marknadsdrivna initiativen för gemensamma standarder anammas av kontoinstituten för att åstadkomma en harmoniserad miljö med open banking.

Presented dissertation thesis is focused on the development of electrochemical methods for the determination of three important tumour biomarkers, namely homovanillic acid (HVA), vanillylmandelic acid (VMA), and 5-hydroxyindole-3-acetic acid (5-HIAA). First part of the study is focused on electrochemical behaviour of these analytes in batch arrangement using differential pulse voltammetry (DPV) at screen-printed carbon electrodes (SPCEs). It has been proved that presented method is sufficiently sensitive for monitoring above mentioned analytes. Moreover, it can be used for determination of HVA and VMA in mixture. Obtained limits of detection (LODs) were 0.24 µmol·L-1 for HVA, 0.06 µmol·L-1 for VMA, and 0.12 µmol·L-1 for 5-HIAA. The requirements to speed up the analysis and at the same time to reduce its price initialized our study of the determination of tested biomarkers in flow systems. Firstly, flow injection analysis with amperometric detection was investigated for the determination of all three biomarkers at the same SPCE, and then an analogous determination of structural more similar pair, HVA and VMA, was performed at a boron doped diamond electrode (BDDE). Obtained LODs of optimized methods were as follows: at SPCE 0.07 µmol·L-1 for HVA, 0.05 µmol·L-1 for VMA, and 0.03 µmol·L-1 for 5-HIAA,...

Cette recherche-création cherche à comprendre la relation particulière qu'une artiste entretient avec la composition sonore, la lutherie numérique et la médiation culturelle au sein d'une démarche unique dédiée à la création d'œuvres didactiques pour publics non-initiés : « La couleur du son » et « Art martial sonore ». Pour ce faire, ce mémoire présente d'abord une étude sur chacune de ses disciplines, puis offre une réflexion sur les façons de les faire coexister. Sont ensuite étudiées différentes créations originales s'inscrivant dans ces trois disciplines. Chacune de ces créations se concentre principalement sur une discipline et tisse autour de cette dernière des liens avec les deux autres dans une démarche unifiée. / This research-creation project aims to understand the specific relationship of an artist wanting to work on sound composition, digital lutherie and cultural mediation in a unique creative process dedicated to the creation of didactic art projects for non-initiated publics : "La couleur du son" and "Art martial sonore". To do so, this master's thesis first presents a study for each of the field, one at a time, before presenting a reflexion on how they can coexist. Are then studied different original art projects containing each of the three field of works, created specifically for this research-creation. Each of those creations concentrates mainly on one of the three fields of work and connect the other two to it in a way that seeks to be as uniform as possible.

This research was aimed at the optimisation of the usability of content-rich computer and mobile based e-learning material. The goal was to preserve the advantages of paper based material in designing optimised modules that were mobile and computer-based, but at the same time avoiding the pitfalls of converting traditional paper based learning material for use on screen. A mobile eye tracker was used to analyse how students studied similar course content on paper, and on mobile device. Screen based eye tracking was also used to analyse how participants studied corresponding content on a desktop screen. Eye movements which were recorded by an eye tracker revealed the sequences of fixations and saccades on the text that was read by each participant. By analysing and comparing the eye gaze patterns of students reading the same content on three different delivery platforms, the differences between these platforms were identified in terms of their delivery of content rich, text based study material. The results showed that more students read online content on a computer screen than on mobile devices. The inferential analysis revealed that the differences in reading duration, comprehension, linearity and fixation count on the three platforms were insignificant. There were significant differences in saccade length. This analysis was used to identify strong aspects of the respective platforms and consequently derive guidelines for using these aspects optimally to design content rich material for delivery on computer screen and mobile device. The limitations of each platform were revealed and guidelines for avoiding these were derived / Computing / M. Sc. (Computing)

Diese Dissertation befasst sich mit der industrienahen Herstellung von Katalysatorschichten für Polymer-Elektrolyt-Membran-Brennstoffzellen mit Hilfe des Tiefdrucks als Fertigungsverfahren. Um die Anforderungen an die Katalysatorschicht hinsichtlich der Schichtdicke zu erreichen, wird ein Linienraster für den Tiefdruck entwickelt. Das patentierte und verifizierte Designkonzept des Linienrasters ermöglicht es, trotz Tinten mit geringem Feststoffgehalt hohe Trockenschichtdicken zu erzeugen. Aufgrund des verwendeten Tiefdruckrasters sind Optimierungsschritte an der Fertigungsanlage notwendig, um eine hohe Schichtqualität zu erreichen. Schließlich werden kontinuierlich und industrienah Katalysatorschichten gefertigt, die als Membran-Elektroden-Einheit in einer Polymer-Elektrolyt-Membran-Brennstoffzelle erfolgreich eingesetzt werden. / This work presents an industrial close manufacturing process of active electrodes for Polymer Electrolyte Fuel Cells utilizing an adapted gravure printing process. To meet the requirements of the electrodes regarding the layer thickness (weight) and quality a novel line screen with maximized dipping volume for gravure printing was developed and investigated. A design rule for this kind of screens was realized and verified by a successful manufacturing of electrodes with different dried layer thicknesses. Due to the rough structure and the high dipping volumes of these line screens an adaption and optimization of the machinery and the whole process was necessary to achieve high quality electrodes. Finally, it is shown that it is possible to manufacture continuiously in an industrial close roll-to-roll process platinum loaded electrodes, working successful as cathode in a Membran-Electrode-Assembly.

No description available.

Les leucémies myéloïdes aiguës (LMA) consistent en un groupe de cancers agressifs causés par une accumulation de mutations génétiques et épigénétiques survenant dans les cellules souches ou progénitrices de la moelle osseuse. Il s’agit d’un groupe de maladies très hétérogène, caractérisé par un grand nombre de combinaisons d’altérations qui perturbent à la fois les voies de signalisation qui y sont exprimées, leur sensibilité aux différents traitements et le pronostic des patients. Le déploiement des technologies de séquençage de nouvelle génération au courant de la dernière décennie a permis l’exploration à une échelle sans précédent du paysage mutationnel et transcriptomique de différents cancers, incluant les LMA. Dans le cadre de nos travaux, nous avons voulu tester l'hypothèse selon laquelle les LMA se déclinent en plusieurs sous-groupes génétiques caractérisés chacun par des mutations distinctes et une expression génique dérégulée, ainsi qu’une réponse différentielle à des molécules qui pourraient représenter de nouvelles stratégies thérapeutiques. Nous avons testé cette hypothèse au sein de la cohorte Leucegene, qui comprend un grand nombre de LMA primaires analysées par le séquençage du transcriptome, et nous avons analysé les différences entre les différents sous-groupes en les analysant un à la fois. Cette étude des différents sous-groupes nous a permis de disséquer le profil génomique, transcriptomique et les sensibilités aux petites molécules de sept sous-groupes génétiques, représentant environ la moitié des cas de LMA de l’adulte. Notre approche a permis de découvrir plusieurs nouvelles mutations spécifiques aux différents sous-groupes, dont certaines ont été validées dans des cohortes indépendantes. Nous avons également confirmé que les gènes différentiellement exprimés dans les sous-groupes sont plus informatifs que les signatures d'expression non supervisées pour identifier les biomarqueurs de la maladie. Nous avons ainsi identifié dans la majorité des sous-groupes des gènes représentant un biomarqueur d'intérêt, ayant une pertinence fonctionnelle ou pronostique. Ces données ont également mené à des criblages chimiques ciblés qui ont identifié de nouvelles vulnérabilités dépendant du contexte génétique. Au-delà de ces observations, nos travaux pourraient avoir une portée translationnelle tandis que le séquençage de nouvelle génération est de plus en plus utilisé en clinique. La combinaison avec d’autres modalités de séquençage et l’incorporation de technologies émergentes aideront à poursuivre la dissection génomique, transcriptomique et chimique de la LMA et l’approche utilisée pourra même éventuellement s’appliquer à d’autres types de cancers. / Acute myeloid leukemias (AML) are a group of cancers caused by an accumulation of genetic and epigenetic mutations occurring in the stem or progenitor cells of the bone marrow. They represent a very heterogeneous group of diseases, characterized by a large number of combinations of alterations which disrupt to varying degrees key networks in these cells, their sensitivity to treatments and the prognosis of the patients. The deployment of next-generation sequencing technologies over the past decade has enabled exploration on an unprecedented scale of the mutational and transcriptomic landscape of various cancers, including AML. As part of our work, we tested the hypothesis according to which AMLs comprise several genetic subgroups, each characterized by distinct mutations and deregulated gene expression profiles, as well as a differential response to molecules that could represent novel therapies. We tested this hypothesis in the Leucegene cohort, which includes a large number of primary AMLs analyzed by transcriptome sequencing, which we explored one subgroup after the other, dissecting the genomic, transcriptomic or small molecule sensitivities profile of seven AML subgroups representing approximately half of adult AML cases. Our approach has allowed us to discover several new mutations specific to different subgroups, some of which have been validated in independent cohorts. We also confirmed that genes differentially expressed in subgroups are more informative than unsupervised expression signatures, and we identified genes representing potential biomarkers, or having a functional or prognostic relevance in the majority of subgroups. Generated data also led to targeted chemical screens performed on primary AML cells, which identified new context-dependent vulnerabilities. Beyond these observations, our work could have a translational scope while next-generation sequencing is paving its way in the clinic. The combination with other Omics and the incorporation of emerging technologies will help to further the multi-dimensional dissection of these groups and additional ones, as the presented approach could be applied to additional disease subsets and cancer types.