Today’s increasing information supply raises the needfor more effective and automated information processing whereindividual information adaptation (personalization) is onepossible solution. Earlier computer systems for personalizationlacked the ability to easily define and measure theeffectiveness of personalization efforts. Numerous projectsfailed to live up to the their expectations, and the demand forevaluation increased. This thesis presents some underlying concepts and methodsfor implementing personalization in order to increase statedbusiness objectives. A personalization system was developedthat utilizes descriptions of information characteristics(metadata) to perform content based filtering in anon-intrusive way. Most of the described measurement methods forpersonalization in the literature are focused on improving theutility for the customer. The evaluation function of thepersonalization system described in this thesis takes thebusiness operator’s standpoint and pragmatically focuseson one or a few measurable business objectives. In order toverify operation of the personalization system, a functioncalled bifurcation was created. The bifurcation functiondivides the customers stochastically into two or morecontrolled groups with different personalizationconfigurations. Bygiving one of the controlled groups apersonalization configuration that deactivates thepersonalization, a reference group is created. The referencegroup is used to measure quantitatively objectives bycomparison with the groups with active personalization. Two different companies had their websites personalized andevaluated: one of Sweden’s largest recruitment servicesand the second largest Swedish daily newspaper. The purposewith the implementations was to define, measure, and increasethe business objectives. The results of the two case studiesshow that under propitious conditions, personalization can bemade to increase stated business objectives. Keywords:metadata, semantic web, personalization,information adaptation, one-to-one marketing, evaluation,optimization, personification, customization,individualization, internet, content filtering, automation. / <p>QCR 20161027</p>

The One-to-One project is initiated in schools across the country but there is no research on how it affects the students' physical work environment and health from a holistic perspective. Both national, public and private schools face a need to develop the work environment, especially for the students, as the school implements the One-to-One PCs. The study aims to investigate the impact of One-to-One computers on students’ physical and mental health in a work environmental perspective in a secondary school. This study examines: How does the introduction of One-to-One PCs affect mental and physical work environment for pupils in an upper secondary school with vocational training? The study was conducted as a quantitative survey of students at a Swedish secondary school. The result includes that students feel the school work is not geared towards working with a computer as a tool, and that there is a lot that can be done regarding school environment. The study discusses aspects of pupils' health and changes that could improve the school environment.

University of Macau / Faculty of Social Sciences. / Department of Government and Public Administration

Dans cette thèse des actions conformes de cohomogénéité un sur l'univers d'Einstein tridimensionel sont classifiées. Notre stratégie est d'établir dans un premier temps quel peut être le groupe de transformations conformes impliqué, à conjugaison près. Nous décrivons aussi la topologie et la nature causale des orbites d'une telle action. / In this thesis, the conformal actions of cohomogeneity one on the three-dimensional Einstein universe are classified. Our strategy in this study is to determine the representation of the acting group in the group of conformal transformations of Einstein universe up to conjugacy. Also, we describe the topology and the causal character of the orbits induced by cohomogeneity one actions in Einstein universe.

Attrition rates among applied music students accelerate as young people progress through adolescence. Once disengaged from music participation in the teenage years, disinterest tends to persist throughout adulthood. The aim of this qualitative study was to investigate the teaching practices of applied music teachers as they worked with teenagers at a talent development level referred to as second phase (Bloom, 1985), which is typically reached in adolescence. The study investigated teaching and learning behaviors in the lessons, teachers’ management of para-instructional decisions (such as monitoring students’ progress and recommending students for collegiate-level study), and teachers’ strategies for influencing, motivating, and nurturing students. Purposeful sampling was used to recruit six classical guitar, harp, and piano teachers. Data collected from music lesson observations, semi-structured interviews, and documents were analyzed typologically for occurrences of predetermined categories of instructional behaviors and inductively for emergent themes. The study revealed several findings. Verbal directives and questions, positive approbations, and playing models dominated the teachers’ behavior. The teachers accommodated individual learning styles and empowered their students by providing them with decision-making opportunities. The teachers’ pedagogies were systematic and goal driven, with refined tone and strategies for lifelong music making among the pedagogical foci. Musical analysis was integral to the teaching, as it served to deepen students’ intellectual understanding of the music and support their memorization during performances. The teachers prescribed exact practice routines, which most of them provided in written form. The findings suggest that in light of the voluntary nature of applied music study in adolescence and the many activities competing for students’ time, a chief concern of the teachers was to influence and motivate their students to continue their participation in music lessons. The teachers accomplished this by utilizing six categories of teaching strategies, some of which could involve decisions contrary to their own musical preferences and pedagogical inclinations. The strategies’ synergy maximized the facilitation of positive student experiences, particularly those associated with public performance. These experiences seemed to fulfill students’ drive for independence, satisfy their need for recognition, and boosted their motivation to work towards achieving higher proficiency levels. / 2024-03-31T00:00:00Z

O labirinto em cruz elevado (LCE) é um dos testes de ansiedade mais empregados na atualidade. Uma característica intrigante desse modelo é a abolição dos efeitos ansiolíticos dos benzodiazepínicos como resultado de uma única experiência prévia no labirinto. Este fenômeno, chamado “one-trial tolerance” (OTT), tem recebido considerável atenção e dentre as diversas hipóteses sugeridas para explicá-lo, podemos citar uma alteração no estado emocional do animal, perda do conflito motivacional e habituação do comportamento exploratório. A descoberta de que benzodiazepínicos reduzem a atividade de neurônios serotoninérgicos, associada a resultados obtidos em testes de conflito que mostram que antagonistas serotoninérgicos podem causar efeitos ansiolíticos comparáveis aos benzodiazepínicos, levaram à noção de que a serotonina (5-HT) é o principal neurotransmissor envolvido na ansiedade. No entanto, com o uso de outros modelos animais, o envolvimento da 5-HT tem sido questionado, ao mesmo tempo em que outras aminas biogênicas, como a noradrenalina (NA), têm sido implicadas na modulação da ansiedade. Nesse estudo procedemos uma análise etofarmacológica de ratos tratados com o antagonista serotoninérgico cetanserina e os antidepressivos fluoxetina e desipramina submetidos ao teste e reteste no LCE. Esses antidepressivos aumentam os níveis sinápticos de 5-HT e NA, respectivamente. Além disso, foram medidas as concentrações plasmáticas de corticosterona - considerada um índice confiável de medo e estresse - de ratos expostos à sessão única ou repetida no LCE. As drogas administradas antes da reexposição ao labirinto não produziram efeitos ansiolíticos, replicando o fenômeno da OTT comumente associado aos benzodiazepínicos. Por outro lado, a cetanserina administrada antes da primeira sessão produziu um efeito ansiolítico, mas o tratamento subcrônica com fluoxetina e desipramina não alterou o comportamento exploratório dos animais no LCE. Ratos submetidos à sessão única ou repetida no labirinto apresentaram um aumento similar dos níveis plasmáticos de corticosterona, indicando que a reexposição ao LCE apresenta propriedades aversivas e a OTT deve estar mais relacionada à uma alteração no estado emocional do animal do que à habituação do comportamento exploratório. / The elevated plus-maze (EPM) is currently one of the most used test of anxiety. An intriguing feature of this model is the abolition of the anxiolytic effect of benzodiazepines by a single previous experience with the maze. This phenomenon, termed one-trial tolerance (OTT), has received considerable attention and among the several hypotheses suggested to explain it, we can listed a shift in the animal emotional state, lack of motivational conflict and exploratory behavior habituation. The discovery that benzodiazepines reduce the activity of serotonergic neurons, associated with results obtained in conflict tests showing that serotonergic antagonists may cause anxiolitic-like effects comparable to the benzodiazepines, has led to the notion that the serotonin (5-HT) is the most important neurotransmitter involved in the anxiety. Nevertheless, with the use of other animal models, the 5-HT involvement has been questioned, at the same time that other biogenic amines, such as noradrenalin (NA), have been implicated in the anxiety modulation. In this study, we carried out an ethopharmacological analysis of rats under treatment with the serotonergic antagonist ketanserin and the antidepressants fluoxetine and desipramine submitted to the test and retest in the EPM. These antidepressants increase the synaptic levels of 5-HT and NA, respectively. Besides, plasma corticosterone concentrations - considered a reliable index of fear and stress - of rats exposed once or twice to the EPM were measured. The drugs injected before the retest in the EPM did not produce anxiolytic effects, replicating the OTT phenomenon generally associated with the benzodiazepines. On the other hand, ketanserin injected before the first session produced an anxiolytic effect but the subchronic treatment with fluoxetine and desipramine did not change the exploratory behavior of the animals in the EPM. Naive and experienced rats show a similar increase in the plasma corticosterone levels when submitted to the EPM, indicating that the retest to EPM has aversive properties and the OTT may be more related to a change in the emotional state of the animal than to a habituation of the exploratory behavior.

O labirinto em cruz elevado (LCE) é um dos testes de ansiedade mais empregados na atualidade. Uma característica intrigante desse modelo é a abolição dos efeitos ansiolíticos dos benzodiazepínicos como resultado de uma única experiência prévia no labirinto. Este fenômeno, chamado “one-trial tolerance" (OTT), tem recebido considerável atenção e dentre as diversas hipóteses sugeridas para explicá-lo, podemos citar uma alteração no estado emocional do animal, perda do conflito motivacional e habituação do comportamento exploratório. A descoberta de que benzodiazepínicos reduzem a atividade de neurônios serotoninérgicos, associada a resultados obtidos em testes de conflito que mostram que antagonistas serotoninérgicos podem causar efeitos ansiolíticos comparáveis aos benzodiazepínicos, levaram à noção de que a serotonina (5-HT) é o principal neurotransmissor envolvido na ansiedade. No entanto, com o uso de outros modelos animais, o envolvimento da 5-HT tem sido questionado, ao mesmo tempo em que outras aminas biogênicas, como a noradrenalina (NA), têm sido implicadas na modulação da ansiedade. Nesse estudo procedemos uma análise etofarmacológica de ratos tratados com o antagonista serotoninérgico cetanserina e os antidepressivos fluoxetina e desipramina submetidos ao teste e reteste no LCE. Esses antidepressivos aumentam os níveis sinápticos de 5-HT e NA, respectivamente. Além disso, foram medidas as concentrações plasmáticas de corticosterona - considerada um índice confiável de medo e estresse - de ratos expostos à sessão única ou repetida no LCE. As drogas administradas antes da reexposição ao labirinto não produziram efeitos ansiolíticos, replicando o fenômeno da OTT comumente associado aos benzodiazepínicos. Por outro lado, a cetanserina administrada antes da primeira sessão produziu um efeito ansiolítico, mas o tratamento subcrônica com fluoxetina e desipramina não alterou o comportamento exploratório dos animais no LCE. Ratos submetidos à sessão única ou repetida no labirinto apresentaram um aumento similar dos níveis plasmáticos de corticosterona, indicando que a reexposição ao LCE apresenta propriedades aversivas e a OTT deve estar mais relacionada à uma alteração no estado emocional do animal do que à habituação do comportamento exploratório. / The elevated plus-maze (EPM) is currently one of the most used test of anxiety. An intriguing feature of this model is the abolition of the anxiolytic effect of benzodiazepines by a single previous experience with the maze. This phenomenon, termed one-trial tolerance (OTT), has received considerable attention and among the several hypotheses suggested to explain it, we can listed a shift in the animal emotional state, lack of motivational conflict and exploratory behavior habituation. The discovery that benzodiazepines reduce the activity of serotonergic neurons, associated with results obtained in conflict tests showing that serotonergic antagonists may cause anxiolitic-like effects comparable to the benzodiazepines, has led to the notion that the serotonin (5-HT) is the most important neurotransmitter involved in the anxiety. Nevertheless, with the use of other animal models, the 5-HT involvement has been questioned, at the same time that other biogenic amines, such as noradrenalin (NA), have been implicated in the anxiety modulation. In this study, we carried out an ethopharmacological analysis of rats under treatment with the serotonergic antagonist ketanserin and the antidepressants fluoxetine and desipramine submitted to the test and retest in the EPM. These antidepressants increase the synaptic levels of 5-HT and NA, respectively. Besides, plasma corticosterone concentrations - considered a reliable index of fear and stress - of rats exposed once or twice to the EPM were measured. The drugs injected before the retest in the EPM did not produce anxiolytic effects, replicating the OTT phenomenon generally associated with the benzodiazepines. On the other hand, ketanserin injected before the first session produced an anxiolytic effect but the subchronic treatment with fluoxetine and desipramine did not change the exploratory behavior of the animals in the EPM. Naive and experienced rats show a similar increase in the plasma corticosterone levels when submitted to the EPM, indicating that the retest to EPM has aversive properties and the OTT may be more related to a change in the emotional state of the animal than to a habituation of the exploratory behavior.

One-to-one mobile technology integration is the goal of increasing numbers of school districts each year, and many factors exist to consider when measuring success. The research problem for this qualitative study focused on one of the critical components for measuring success: the need for effective teacher professional development. The purpose of this study was to examine (a) principles and practices to facilitate the integration of one-to-one mobile technologies into professional learning experiences, and (b) the perceptions of technology instructional coaches regarding changes in teachers' practice and attitudes following professional development. The conceptual framework included Knowles's theory of andragogy and Koehler and Mishra's TPACK framework. In two rounds, 19 interviews were conducted with 13 technology instructional coaches. Thirteen coaches were interviewed in round one and from that data six high level coaches were identified for a second round of interviews. The data from both interview rounds were analyzed and coded to identify themes and categories. The key findings revealed that effective one-to-one mobile technology integration requires supportive leadership; building culture and relationships; instructional design with standards and frameworks; building collaborative, job-embedded teacher agency; and personalized learning with differentiated delivery. All stakeholders could use the key results to make informed decisions for planning and implementing professional learning opportunities. This study may affect positive social change by enhancing how technology is integrated into teaching and learning through increased teacher engagement in professional learning.

<p>Priestley's One-to-One CBT programme is intended to reduce criminal recidivism. Data were collected from 1484 programme rounds in Sweden. 776 of these cases contained the data necessary for this study and were used in the analyses. The data included pre- and postprogramme test scores on areas addressed in the programme. The purpose of this study was to examine whether the tests or background data of participants have predictive properties for dropout and recidivism and whether test scores differ between sub-groups. To do this, t-tests and logistic regression analyses were performed. There were significant improvements on all scores post-programme. Only age predicted completion, with older participants being more likely to complete the program. Several variables were found to have predictive properties for recidivism. The most potent predictor for nonrecidivism was programme completion. The study finds a relation between some of the tests measuring psychological change, and recidivism. This partly supports the theory behind the programme.</p><p> </p>

<p>This thesis describes how radical cyclization chemistry can be applied for the construction of heterocyclic compounds.</p><p>In the first part, a series of electron deficient α-phenylselenenylalkenes were prepared <i>via</i> a PhSeCl-addition/HCl-elimination sequence. Allyl- and propargylamines readily underwent conjugate addition to these species to produce pyrrolidines or dihydropyrrol derivatives, after triethylborane initiated reductive radical cyclization in the presence of tris(trimethylsilyl)silane.</p><p>The second part describes a convergent synthesis of the pineal hormone melatonin. The indole nucleus is secured <i>via</i> a tris(trimethylsilyl)silane mediated<i> 5-exo</i> radical cyclization. The protocol provides convenient and simple access to compounds useful for studies of biological activity and structure activity relationships.</p><p>The third part describes construction of substituted tetrahydrofuran-3-ones and pyrrolidin-3-ones. Regioselective ring-opening of epoxides or aziridines with benzeneselenolate/tellurolate, followed by Michael addition to electron deficient alkynes afforded the corresponding O/N-vinylated compounds. The tetrahydrofuran-3-ones and pyrrolidin-3-ones were secured <i>via </i>radical carbonylation/reductive cyclization using pressurized carbon monoxide (80 atm).</p><p>The fourth part is concerned with the effect of an N-protecting group on the cyclization of 2-substituted-3-aza-5-hexenyl radicals. Relative energies for reactants and transition states were determined using density functional calculations. Reactant and transition state conformers leading to <i>cis</i>-product were lower in energy than those leading to<i> trans</i>-product. The results can be explained by the unfavorable 1,2-strain present in chair-equatorial and boat-equatorial conformers.</p>