O objetivo deste estudo foi analisar e comparar os efeitos de 12 semanas do treinamento de força (TF) com o treinamento de força com instabilidade (TFI) nos desfechos clínicos, na capacidade de produção de força muscular, nos mecanismos inibitórios espinhais e no volume total de treinamento (VTT) de indivíduos entre os estágios 2 e 3 da doença de Parkinson (DP). Para tanto, 39 indivíduos (testados e treinados no estado \"on\" da medicação) atenderam aos critérios de inclusão e foram randomizados em três grupos: grupo controle nenhum exercício (GC), grupo TF (GTF) e grupo TFI (GTFI). O GTF e o GTFI realizaram 12 semanas de TF orientado à hipertrofia, duas vezes por semana, em dias não consecutivos. Apenas o GTFI adicionou acessórios de instabilidade (e.g., BOSU®) ao TF que progrediram dos menos para os mais instáveis. Antes e após as 12 semanas foram avaliados os seguintes desfechos: a) clínicos - mobilidade (desfecho primário), sintomas motores, comprometimento cognitivo, medo de cair, equilíbrio, desempenho da marcha (distância, cadência e velocidade) em condições de dupla tarefa e qualidade de vida; b) capacidade de produção de força muscular - raiz quadrada média (RMS), mean spike frequency (MSF) e retardo eletromecânico (REM) dos músculos vasto lateral, vasto medial e gastrocnêmio medial; pico de torque, taxa de desenvolvimento de torque (TDT) e tempo de meio relaxamento (TMR) dos músculos extensores do joelho e flexores plantares; uma repetição máxima (1RM) dos membros inferiores e área de secção transversa do músculo quadríceps femoral (ASTQ) e; c) mecanismos inibitórios espinhais - inibições pré-sináptica e recíproca do músculo sóleus. O VTT foi avaliado durante o protocolo experimental para os exercícios agachamento, flexão plantar e leg-press. Do pré ao pós-treinamento, somente o GTFI melhorou todos os desfechos clínicos (P<0,05), os desfechos da capacidade de produção de força muscular (P<0,05) com exceção do TMR dos músculos extensores de joelho (P=0.068) e melhorou os desfechos dos mecanismos inibitórios espinhais (P<0,05). Houve diferenças significantes entre o GTFI e o GC no pós-treinamento para os seguintes desfechos: mobilidade, comprometimento cognitivo, equilíbrio, desempenho na marcha em condições de dupla tarefa (distância, cadência e velocidade), RMS de todos os músculos avaliados, MSF do músculo gastrocnêmio medial, pico de torque e TDT dos flexores plantares, pico de torque dos extensores de joelho, 1RM dos membros inferiores e inibições pré-sináptica e recíproca (P<0,05). Além disso, o GTFI apresentou melhores valores do que o GTF para os seguintes desfechos: desempenho na marcha em condições de dupla tarefa (distância e velocidade), RMS do músculo vasto medial, MSF do músculo gastrocnêmio medial, TDT dos flexores plantares e inibições pré-sináptica e recíproca (P<0,05). O GTFI apresentou um menor VTT comparado ao GTF (P<0,05). Por fim, nenhum efeito adverso foi observado. Em conclusão, somente o TFI melhorou os desfechos clínicos e foi mais efetivo do que o TF em promover adaptações neuromusculares mesmo com um menor VTT. Assim, o TFI é recomendado como uma inovadora intervenção terapêutica para minimizar os declínios na mobilidade e em um amplo espectro de deficiências, sem causar efeitos adversos em indivíduos com DP / The aim of this study was to analyze and to compare the effects of 12 weeks of strength training (ST) with strength training with instability (STI) on clinical outcomes, muscle-force-production capacity, spinal inhibitory mechanisms and the total training volume (TTV) of individuals between stages 2 and 3 of Parkinson\'s disease (PD). For this, 39 individuals (assessed and trained in the clinically defined \"on\" state) met the inclusion criteria and were randomized into three groups: non-exercising control group (CG), ST group (STG) and STI group (STIG). The STG and STIG performed 12 weeks hypertrophy-oriented ST, twice a week, on non-consecutive days. Only STIG added unstable devices (e.g., BOSU®) to ST that progressed from the less to the more unstable devices. Before and after 12 weeks were assessed the following outcomes: a) clinical - mobility (primary outcome), motor symptoms, cognitive impairment, fear of falling, balance, dual-task gait performance (distance, cadence, and, velocity), and quality of life; b) muscle-force-production capacity - root mean square (RMS), mean spike frequency (MSF), and electromechanical delay (EMD) of the vastus lateralis, vastus medialis, and gastrocnemius medialis; peak torque, rate of torque development (RTD) and half-relaxation time (HRT) of the knee-extensors and plantar flexors; one repetition maximum (1-RM) of the lower limbs and quadriceps cross sectional area (QCSA) and; c) spinal inhibitory mechanisms - presynaptic inhibition and reciprocal inhibition of the soleus muscle. The TTV for each lower limb exercise (half-squat, plantar flexion, and leg-press) was determined during the experimental protocol. From pre- to post-training, only the STIG improved all of the clinical outcomes (P <0.05), the muscle-force-production capacity outcomes (P <0.05) with exception of the HRT of the knee-extensors (P = 0.068) and, improved the spinal inhibitory mechanisms outcomes (P <0.05). There were differences between the STIG and the CG for the following outcomes: mobility, cognitive impairment, balance, dual-task gait performance (distance, cadence, and speed), RMS all of the muscles assessed, MSF of the gastrocnemius medialis, peak torque and RTD of the plantar flexor, peak torque of the knee-extensors, 1RM of the lower limbs, presynaptic inhibition, and reciprocal inhibition at post-training (P <0.05). Moreover, the STIG showed better values than the STG for the following outcomes: dual-task gait performance (distance and speed), RMS of the vastus medialis, MSF of the gastrocnemius medialis, RTD of the plantar flexors, presynaptic inhibition, and reciprocal inhibition at post-training (P <0.05). The STIG showed a lower TTV than the STG (P <0.05). Finally, no adverse effects were observed. In conclusion, only the STIG improved all of the clinical outcomes and it was more effective than the STG to promote neuromuscular adaptations even the STIG has had a lower TTV than the STG. Thus, STI is recommended as a novel therapeutic intervention to minimize declines in mobility and in a wide spectrum of impairments without causing adverse effects in individuals with PD

O objetivo deste estudo foi analisar e comparar os efeitos de 12 semanas do treinamento de força (TF) com o treinamento de força com instabilidade (TFI) nos desfechos clínicos, na capacidade de produção de força muscular, nos mecanismos inibitórios espinhais e no volume total de treinamento (VTT) de indivíduos entre os estágios 2 e 3 da doença de Parkinson (DP). Para tanto, 39 indivíduos (testados e treinados no estado \"on\" da medicação) atenderam aos critérios de inclusão e foram randomizados em três grupos: grupo controle nenhum exercício (GC), grupo TF (GTF) e grupo TFI (GTFI). O GTF e o GTFI realizaram 12 semanas de TF orientado à hipertrofia, duas vezes por semana, em dias não consecutivos. Apenas o GTFI adicionou acessórios de instabilidade (e.g., BOSU®) ao TF que progrediram dos menos para os mais instáveis. Antes e após as 12 semanas foram avaliados os seguintes desfechos: a) clínicos - mobilidade (desfecho primário), sintomas motores, comprometimento cognitivo, medo de cair, equilíbrio, desempenho da marcha (distância, cadência e velocidade) em condições de dupla tarefa e qualidade de vida; b) capacidade de produção de força muscular - raiz quadrada média (RMS), mean spike frequency (MSF) e retardo eletromecânico (REM) dos músculos vasto lateral, vasto medial e gastrocnêmio medial; pico de torque, taxa de desenvolvimento de torque (TDT) e tempo de meio relaxamento (TMR) dos músculos extensores do joelho e flexores plantares; uma repetição máxima (1RM) dos membros inferiores e área de secção transversa do músculo quadríceps femoral (ASTQ) e; c) mecanismos inibitórios espinhais - inibições pré-sináptica e recíproca do músculo sóleus. O VTT foi avaliado durante o protocolo experimental para os exercícios agachamento, flexão plantar e leg-press. Do pré ao pós-treinamento, somente o GTFI melhorou todos os desfechos clínicos (P<0,05), os desfechos da capacidade de produção de força muscular (P<0,05) com exceção do TMR dos músculos extensores de joelho (P=0.068) e melhorou os desfechos dos mecanismos inibitórios espinhais (P<0,05). Houve diferenças significantes entre o GTFI e o GC no pós-treinamento para os seguintes desfechos: mobilidade, comprometimento cognitivo, equilíbrio, desempenho na marcha em condições de dupla tarefa (distância, cadência e velocidade), RMS de todos os músculos avaliados, MSF do músculo gastrocnêmio medial, pico de torque e TDT dos flexores plantares, pico de torque dos extensores de joelho, 1RM dos membros inferiores e inibições pré-sináptica e recíproca (P<0,05). Além disso, o GTFI apresentou melhores valores do que o GTF para os seguintes desfechos: desempenho na marcha em condições de dupla tarefa (distância e velocidade), RMS do músculo vasto medial, MSF do músculo gastrocnêmio medial, TDT dos flexores plantares e inibições pré-sináptica e recíproca (P<0,05). O GTFI apresentou um menor VTT comparado ao GTF (P<0,05). Por fim, nenhum efeito adverso foi observado. Em conclusão, somente o TFI melhorou os desfechos clínicos e foi mais efetivo do que o TF em promover adaptações neuromusculares mesmo com um menor VTT. Assim, o TFI é recomendado como uma inovadora intervenção terapêutica para minimizar os declínios na mobilidade e em um amplo espectro de deficiências, sem causar efeitos adversos em indivíduos com DP / The aim of this study was to analyze and to compare the effects of 12 weeks of strength training (ST) with strength training with instability (STI) on clinical outcomes, muscle-force-production capacity, spinal inhibitory mechanisms and the total training volume (TTV) of individuals between stages 2 and 3 of Parkinson\'s disease (PD). For this, 39 individuals (assessed and trained in the clinically defined \"on\" state) met the inclusion criteria and were randomized into three groups: non-exercising control group (CG), ST group (STG) and STI group (STIG). The STG and STIG performed 12 weeks hypertrophy-oriented ST, twice a week, on non-consecutive days. Only STIG added unstable devices (e.g., BOSU®) to ST that progressed from the less to the more unstable devices. Before and after 12 weeks were assessed the following outcomes: a) clinical - mobility (primary outcome), motor symptoms, cognitive impairment, fear of falling, balance, dual-task gait performance (distance, cadence, and, velocity), and quality of life; b) muscle-force-production capacity - root mean square (RMS), mean spike frequency (MSF), and electromechanical delay (EMD) of the vastus lateralis, vastus medialis, and gastrocnemius medialis; peak torque, rate of torque development (RTD) and half-relaxation time (HRT) of the knee-extensors and plantar flexors; one repetition maximum (1-RM) of the lower limbs and quadriceps cross sectional area (QCSA) and; c) spinal inhibitory mechanisms - presynaptic inhibition and reciprocal inhibition of the soleus muscle. The TTV for each lower limb exercise (half-squat, plantar flexion, and leg-press) was determined during the experimental protocol. From pre- to post-training, only the STIG improved all of the clinical outcomes (P <0.05), the muscle-force-production capacity outcomes (P <0.05) with exception of the HRT of the knee-extensors (P = 0.068) and, improved the spinal inhibitory mechanisms outcomes (P <0.05). There were differences between the STIG and the CG for the following outcomes: mobility, cognitive impairment, balance, dual-task gait performance (distance, cadence, and speed), RMS all of the muscles assessed, MSF of the gastrocnemius medialis, peak torque and RTD of the plantar flexor, peak torque of the knee-extensors, 1RM of the lower limbs, presynaptic inhibition, and reciprocal inhibition at post-training (P <0.05). Moreover, the STIG showed better values than the STG for the following outcomes: dual-task gait performance (distance and speed), RMS of the vastus medialis, MSF of the gastrocnemius medialis, RTD of the plantar flexors, presynaptic inhibition, and reciprocal inhibition at post-training (P <0.05). The STIG showed a lower TTV than the STG (P <0.05). Finally, no adverse effects were observed. In conclusion, only the STIG improved all of the clinical outcomes and it was more effective than the STG to promote neuromuscular adaptations even the STIG has had a lower TTV than the STG. Thus, STI is recommended as a novel therapeutic intervention to minimize declines in mobility and in a wide spectrum of impairments without causing adverse effects in individuals with PD

Die Struktur der Landwirtschaft hat sich in vielen westlichen Ländern grundlegend geändert. In Westdeutschland, zum Beispiel, hat die Anzahl der Betriebe deutlich abgenommen, während die durchschnittliche Betriebsgröße von 7,4 ha im Jahr 1950 auf 42,9 ha im Jahr 2013 stieg. Um diese Entwicklung zu verstehen, müssen insbesondere die begrenzten Produktionskapazitäten berücksichtigt werden, die hinsichtlich der verfügbaren landwirtschaftlichen Nutzfläche oder der ehemaligen Milchquote existieren. Solche Kapazitätsbeschränkungen erzeugen einen direkten Zusammenhang zwischen dem Wachsen und Schrumpfen von Betrieben, da die Expansionsmöglichkeiten eines einzelnen Betriebes von frei werdenden Kapazitäten anderer Betriebe abhängen. Aus diesem Grund wird hier zunächst ein dynamisch stochastisches Gleichgewichtsmodell entwickelt, das auf mikroökonomischen Entscheidungen basiert und Markteintritt/-austritt für den Fall ausgeschöpfter Produktionskapazitäten darstellt. Der Kapazitätspreis ist dabei markträumend in dem Sinne, dass die Anzahl neuer Produktionseinheiten mit den aufgegebenen übereinstimmen muss. Die Industrie konvergiert unter diesen Bedingungen gegen ein stationäres Gleichgewicht, in dem Ein- und Austritt vorkommen, die Größenverteilung jedoch unverändert bleibt. Die Anpassung an diesen Zustand wird u.a. beschleunigt, wenn die fixen Eintrittskosten sinken. Eine Version des Modells wird dann auf den westdeutschen Milchsektor angewendet, um den Einfluss einer Quote auf den Strukturwandel zu untersuchen. Verglichen mit dem Szenario freien Wettbewerbs hemmt eine nicht-handelbare Quote die Anpassungsprozesse, während eine handelbare Quote Marktaustritte fördern und zu einer höheren durchschnittlichen Produktivität führen kann. Die Phase nach einer Quotenabschaffung ist geprägt von enormen Kapazitätsausweitungen und stark fallenden Preisen, falls die fixen Eintrittskosten niedrig sind. Diese Entwicklung ist weniger stark ausgebildet für höhere Eintrittskosten. / The agricultural industry in Western countries has undergone a substantial structural change. In West Germany, for instance, the number of farms declined notably during the last decades while the average farm size increased from 7.4 ha in 1950 to 42.9 ha in 2013. A factor that needs to be considered when explaining this development is the limited sectoral production capacity, which exists in terms of agricultural land or the former milk quota regime. This limited capacity generates a direct interrelation between farm growth and farm shrinkage as a single farm''s investment option depends crucially on the possible release of production capacity by competitors. The contribution of this thesis is twofold: First, a dynamic stochastic equilibrium model is developed that accounts for microeconomic decision-making and represents an industry operating at an upper capacity limit. The capacity price is determined endogenously such that it offsets the mass of entering and exiting firms in an equilibrium. It is proven that the industry tends to a stationary equilibrium in the long-run, in which entry and exit still occur but the firm size distribution remains constant. Moreover, the adjustment speed to this steady state increases if either the discount factor or the fixed entry costs decrease. Second, the impact of a production quota on industry dynamics is assessed with regard to the former milk quota regime. After calibrating the model to the West German dairy sector, the quota constrained industry performance is compared to a quota free setup. While a non-tradable quota slows down the adjustment processes within the industry, a tradable production quota can stimulate firm turnover and lead to a higher average productivity level. If the entry costs are rather low, the transition phase after a quota removal is characterised by an enormous expansion of production capacity and a considerable output price drop. This development is less pronounced though for higher entry costs.

This thesis focuses in production business and its management. Theses propose and describe a manufacturing process for particular product. Production process is based on an analysis of final product. Production is scheduled in process form, so it includes process maps of production stages. Simultaneously with the planning, it also determines human needs for production, and calculation of its economics. Thesis also deals with the issue of product quality and suggests way to ensure quality in production.

La capacidad y las buenas prácticas de producción son base para el desarrollo de las empresas y más con la competitividad actual. Por ello, el caso de estudio presentado analiza las operaciones de una MYPE peruana del sector plástico, que habría dispuesto previamente mudarse a una nueva planta. En base a un diagnóstico se identificó un déficit en su capacidad de producción con costos representativos equivalentes al 9% de su facturación anual, derivados de la falta de máquinas e ineficiencias, las cuales aun siendo solucionadas no permitirían satisfacer la demanda, por lo que se confirmó que la decisión de la empresa era correcta. De tal forma, se planteó un proyecto que permitiría el diseño de las nuevas instalaciones de la empresa en un local de mayores dimensiones, con el objetivo de optimizar su capacidad de producción y evitar que las malas prácticas detectadas en la actualidad se repitan, validando su viabilidad mediante un prototipo virtual. Asimismo, en base a los cálculos se lograría aumentar la capacidad instalada en 53.5%, superando a la demanda proyectada dentro de tres años en un 24.90 %, lo que permitiría un mayor crecimiento organizacional en el futuro. / The capacity and good production practices are the basis for the development of companies and more with the current competitiveness. Therefore, the case study presented analyzes the operations of a Peruvian MSE in the plastics sector, which would have previously arranged to move to a new plant. Based on a diagnosis, a deficit in its production capacity was identified with representative costs equivalent to 9% of its annual turnover, derived from the lack of machines and inefficiencies, which, even being solved, would not allow to satisfy the demand, therefore confirmed that the company's decision was correct. In this way, a project was proposed that would allow the design of the company's new facilities in a larger premises, with the aim of optimizing its production capacity and preventing the bad practices detected at present from being repeated, validating their viability through a virtual prototype. Furthermore, based on the calculations, it would be possible to increase the installed capacity by 53.5%, surpassing the projected demand in three years by 24.90%, which would allow greater organizational growth in the future. / Trabajo de investigación

El siguiente trabajo de investigación busca aumentar la capacidad de producción en una Mype de confección de polos, con el fin de reducir el incumplimiento de pedidos, lo cual abarca la entrega incompleta y el retraso en la entrega. Por lo tanto, se realiza un diagnóstico y se identifican tiempos muertos por transporte innecesarios, búsqueda de materiales y exceso de merma por realizar el corte de la tela de manera errónea, para estas causas de la problemática se buscan herramientas indicadas para que puedan adaptarse y mejorar la capacidad. Por ello, se adaptaron herramientas de ingeniería industrial como las 5’s, distribución de planta y estudio de métodos. Sin embargo, para garantizar que los objetivos se realicen se plantea identificar y mejorar la cultura organizacional para que sirva como base del modelo de optimización. Mediante la validación se logrará comprobar si la adaptabilidad de las herramientas operacionales con la mejora de la cultura ayude con el crecimiento de la producción. / This paper proposes an optimization model that seeks to increase the production capacity in a Mype of t-shirt manufacturing to reduce the failure of orders, which includes incomplete delivery and delay in delivery. Therefore, we do a diagnostic, and dead times are identified by: unnecessary transport, search for materials, and excess loss by cutting the fabric in the wrong way; for these causes, suitable tools seek to adapt and improve capacity. Then, we adopted tools such as the 5’s, plant distribution, and method study. However, to ensure to meet objectives are, it is proposed to identify and improve the organizational culture to serve as the basis of the optimization model. Through the validation process, it will be possible to verify whether the adaptability of operational tools with the improvement of culture helps with the growth of production. / Trabajo de Suficiencia Profesional

En metod som används för lagerstyrning, och som fått ökat intresse inom forskningen de senaste åren, är klassificering med multipla kriterier (MCABC). Däremot har forskningen hittills tenderat att koncentrera sig på utveckling av klassificeringsmodeller snarare än på vägledning för tillämpning av modellerna. Studien påvisade med en litteraturstudie att forskningsområdet klassificering med multipla kriterier hade en begränsad mängd vägledning för tillämpning relativt mängden klassificeringsmodeller som utformats. Därför undersökte studien en modifierad lagerstyrningsstrategi. Syftet med studien var att finna produkter som lämpar sig för lagring av produktionskapacitet och att undersöka effekterna på färdigvarulagret om dessa produkter används för lageruppbyggnad inför säsongen. För att finna sådana produkter utformades en klassificeringsmodell med multipla kriterier, GTS-modellen (Good to Store). Modellen testades genom att ett antal scenarier simulerades på ett urval av produkter av det egentillverkade sortimentet i en fabrik. Detta gjordes i en fallstudie av ett företag inom processindustrin vars sortiment har säsongsvariationer. Resultatet av simuleringarna visade att lageruppbyggnad med GTS-modellen inför säsongen innebar att det genomsnittliga lagervärdet och antalet omställningar för det egentillverkade sortimentet minskade med ungefär 14 % vardera, jämfört med nuläget. Samtidigt kunde servicenivån bibehållas på i princip identisk nivå. Görs motsvarande jämförelse enbart på den simulerade delen av sortimentet blir minskningarna ungefär 35 % vardera. / Multi criteria classification (MCABC) is a method used for inventory management which has gained interest in research in recent years. However, research has tended to focus on the development of classification models rather than guidance on the application of the models. This study demonstrated, using a literature review, that the multi criteria classification field had a limited amount of guidance for application compared to the amount of classification models that were developed. Therefore, this study examined a modified inventory management strategy. The purpose of the study was to find products suitable for storing production capacity and to examine the effects on the finished goods inventory if these products are used for stock build-up prior to the season. A multi criteria classification model, the GTS (Good to Store) model, was developed to find such products. The model was tested by simulating several scenarios on a selection of products from the factory-made range. This was conducted in a case study regarding a company in the process industry whose range has seasonal variations. The simulations showed that stock build-up with the GTS model prior to the season resulted in an approximately 14 % decrease in average inventory value and number of setups for the factory-made range, compared to the current situation. At the same time, the service level was almost completely maintained. If the comparison is made exclusively on the simulated part of the assortment, the decrease will be approximately 35 %.