A high-performance liquid chromatography was developed to assay levofloxacin and vancomycin. Fluorescence polarization immunoassay was to assay amikacin. The oseltamivir carboxylate and telavancin concentrations were assayed by high-performance liquid chromatography coupled with tandem mass spectrometry. / An in vitro model was utilized to examine adsorption of antibiotics onto haemofilters. In order to test antibiotics from a range of classes, levofloxacin, amikacin, vancomycin, telavancin, and oseltamivir carboxylate were studied. / In summary, the antibiotic adsorption by haemofilters is a complex process. Both characteristics of antibiotics and haemofilters may determine adsorption. Among the studied antibiotics, in vitro adsorption of amikacin by PAN filters may have clinical significance, thus the routine monitoring of amikacin peak concentration in vivo during CRRT is recommended. / In the in vitro model, blood was pumped from an agitated, glass mixing chamber (heated using an automatic water bath), around a circuit and returned to the mixing chamber using a haemofiltration machine. Ultrafiltrate was also returned to the mixing chamber to constitute a closed circuit. As a result any decrease in drug concentration could only be due to adsorption to the filter and extracorporeal circuit, spontaneous degradation or metabolism by red cells. / The main findings were: (1) low adsorption of levofloxacin and vancomycin by haemofilters at clinically relevant concentrations; (2) significant absolute adsorption of amikacin by polyacrylonitrile haemofilters; (3) the adsorption of antibiotics was membrane-material dependent with greater adsorption by polyacrylonitrile filters; (4) lack of relationship between membrane surface area and amikacin adsorption; (5) the adsorption of levofloxacin is reversible, contrary to irreversibility of vancomycin and amikacin; (6) sieving coefficient of oseltamivir is very near to 1.0. / This thesis investigated: (1) the extent of antibiotic adsorption (levofloxacin, vancomycin, amikacin, telavancin and oseltamivir carboxylate) by haemofilters; (2) the time course of antibiotic adsorption by haemofilters; (3) the effects of plasma albumin concentration, initial dosage, pH, filter membrane material, filter membrane surface area and repeated dosing on adsorption; (4) the reversibility or irreversibility of adsorption; (5) clearance of oseltamivir carboxylate and telavancin by ultrafiltration. / Up to 25% of critically ill patients develop acute renal failure with sepsis being the most common cause. Outside of North and South America, these patients usually receive continuous renal replacement therapy (CRRT) which utilizes high flux haemofilter membranes. Thus it is common for these patients to be concurrently receiving antibiotics and CRRT. However, information about the adsorptive capacity of various haemofilters for most drugs is lacking. / "September 2007." / Advisers: Charles Gomersall; Tony Gin. / Source: Dissertation Abstracts International, Volume: 69-08, Section: B, page: 4659. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2007. / Includes bibliographical references (p. 147-164). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract in English and Chinese. / School code: 1307.

Le traitement de référence des lésions sténosantes carotidiennes de haut grade est la chirurgie associée à un traitement médical. Nous avons mis en place depuis 2003 une base de données prospective colligeant l’ensemble des patients hospitalisés dans notre service pour prise en charge d’une lésion sténosante carotidienne d’indication chirurgicale. Depuis 2012, cette base de données cliniques s’est vue complétée par la mise en place d’une tissuthèque et d’une plasmathèque. Nous présentons ici la méthode de mise en place d’une telle base, puis les résultats de quatre études originales sur la thématique du « patient à risque » en chirurgie carotidienne, portant sur l’influence de la fonction rénale, du délai entre les symptômes et la chirurgie et du statut de l’artère carotide controlatérale sur les résultats de cette chirurgie, ainsi que la proposition d’un score pronostic d’intolérance au clampage carotidien. Nous avons montré que l’insuffisance rénale influait sur les résultats de la chirurgie carotidienne de manière différente en fonction de la méthode d’appréciation de la fonction rénale (créatinine plasmatique, clearance de la créatinine calculée selon Cockcroft-Gault ou selon la formule MDRD) ; que le statut hémodynamique de la carotide controlatérale influait sur le taux de shunt sans modifier la morbidité ; que la chirurgie précoce des sténoses carotidiennes symptomatiques n’était pas grevée d’une surmortalité ; et qu’il était possible dans une certaine mesure de prédire la nécessité de mise en place d’un shunt carotidien. Nous abordons enfin les projets à venir utilisant la collection biologique pour tenter d’identifier les plaques athéromateuses à risque / The treatment of high-grade carotid stenosis is surgery combined with best medical treatment. We established since 2003, a prospective database including all patients hospitalized in our vascular surgery department for management of carotid stenosis. Since 2012, the clinical database was completed for the establishment of a biological database. We present here the method of setting up such a database, and the results of four original studies on the theme of "high-risk patient" for carotid surgery: the influence of renal function, of the delay between symptoms and surgery and of the contralateral carotid artery on outcome and the proposal of a prognostic score of intolerance to carotid clamping. We have shown that renal failure influenced outcome of carotid surgery in different ways depending on the method of assessment of renal function (serum creatinine, creatinine clearance calculated by Cockcroft-Gault or MDRD formula) ; the hemodynamic status of the contralateral carotid affected the rate of shunt without changing morbidity; that early surgery for symptomatic carotid stenosis was not burdened with excess mortality; and that it is possible to predict the need for establishment of a carotid shunt. Finally, we discuss future projects using biological collection to try to identify atherosclerotic plaques at risk

Made available in DSpace on 2016-04-28T20:38:46Z (GMT). No. of bitstreams: 1 Claudia Cassia de Oliveira.pdf: 1310099 bytes, checksum: 4f706e392edb3385a56faf94dcac1a45 (MD5) Previous issue date: 2013-10-10 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / In the epidemiologic transition process in Brazil, we verify the increase of diseases and non-transmissible health problems cardiovascular diseases, chronic respiratory diseases neoplasias, mellitus diabetes, arterial hypertension and chronic renal failure. In 2011, the estimated number of patients in hemodialysis was 91,314 (SBN, 2011). Changes have been occurring in chronic health conditions health systems and care processes, and involve a change in paradigm, from an essentially biological model to a bio psychosocial model. Seeking to understand psychosocial aspects of the life experience of people with Chronic Renal Failure CRF in hemodialysis treatment, we developed this research in a Substitutive Renal Therapy Center, located in Southern Minas Gerais, Brazil. It is a field research with a qualitative approach. In a first stage of the research, we performed periods of daily life observation of the patients who frequented the SRTC. In a second stage, we performed semi structured interviews with ten patients in hemodialysis treatment for at least three years. We adopted an analytical strategy with the data collected from the interviews, the Thematic Analysis, as described from Ezzy (2002). The reports from the patients showed their different life experiences in the different stages of the disease and treatment. The initial confronting of the treatment was marked by the review of their life trajectories, in addition to demanding adaptations to a new life style, with physical, psychological and social wearing, and many losses in their daily life activities. The time elapsed from the diagnosis until the stage in which they were when the interview was conducted seems to have been a soothing, an opportunity of growth, to reorganize life and develop their own manner of resilience. The participation of their family members and of the health team was showed to be relevant for the adaptation process. The hope for a transplant which would release them from hemodialysis is cited by the interviewed in different aspects. Religiosity and family are significant aspects of the patients strength in facing the wearing daily life. Possibilities and gaps in health care with a focus on the transdisciplinary action of the team and on a higher patient autonomy are discussed in the final considerations / ampliação de doenças e agravos não transmissíveis doenças cardiovasculares, doenças respiratórias crônicas, neoplasias, diabetes mellitus, hipertensão arterial e a insuficiência renal crônica. Em 2011, o número estimado de pacientes em hemodiálise foi de 91.314 (SBN, 2011). Mudanças vêm ocorrendo nos sistemas de saúde e nos processos de cuidados às condições crônicas de saúde e envolvem uma mudança de paradigma, de um modelo essencialmente biológico para um modelo biopsicossocial. Em busca de compreender aspectos psicossociais da vivência de pessoas com Insuficiência Renal Crônica-IRC em tratamento hemodialítico desenvolveu-se esta pesquisa, num Centro de Terapia Renal Substitutiva localizado na região sul de Minas Gerais. Trata-se de pesquisa de campo, com abordagem qualitativa. Em uma primeira fase da pesquisa, foram realizados períodos de observação do cotidiano dos pacientes que frequentavam o CTRS. Numa segunda fase foram realizadas entrevistas semiestruturadas com dez pacientes, em tratamento hemodialítico há pelo menos três anos. Adotou-se como estratégia analítica dos dados colhidos nas entrevistas a Análise Temática tal como descrita por Ezzy (2002). Os relatos dos pacientes mostraram serem diferentes as suas vivências nas diferentes etapas do curso do adoecimento e tratamento. O enfrentamento inicial do tratamento revelou-se marcado por uma revisão das suas trajetórias de vida, além de exigir adaptações a um novo cotidiano, com desgaste físico, psíquico e social, e várias perdas nas atividades de suas vidas diárias. O tempo decorrido do diagnóstico até a fase em que se encontravam quando das entrevistas parece ter sido um lenitivo, uma oportunidade para amadurecer, para reorganizar a vida e desenvolver modos próprios de resiliência. A participação de seus familiares e da equipe de saúde mostrou-se relevante para o processo de adaptação. A esperança de realização de um transplante que os libere da hemodiálise é tematizada por todos. A religiosidade e os familiares são aspectos significativos das forças dos pacientes para enfrentamento do cotidiano desgastante. Possibilidades e lacunas do processo de cuidados com foco numa atuação transdisciplinar da equipe e em uma maior autonomia dos pacientes são discutidas nas considerações finais

Source: Dissertation Abstracts International, Volume: 70-03, Section: B, page: 1628. Advisers: Belinda M. Reininger; Henry S. Brown. Includes bibliographical references.

Η τελικού σταδίου χρόνια νεφρική ανεπάρκεια (ΤΣΧΝΑ) είναι η αμετάκλητη απώλεια της νεφρικής λειτουργίας. Όταν η απώλεια της νεφρικής λειτουργίας φτάσει στο σημείο όπου οι νεφροί δεν μπορούν να συντηρήσουν τον ασθενή στην ζωή, τότε απαιτείται θεραπεία υποκατάστασης της νεφρικής λειτουργίας (ΘΥΝΛ). που είναι η αιμοκάθαρση (ΑΜΚ), η περιτοναϊκή κάθαρση, ή η μεταμόσχευση νεφρού. Η ενδονοσοκομειακή ΑΜΚ πραγματοποιείται 3 φορές την εβδομάδα και διαρκεί 3-5 ώρες. Η κατ' οίκον ΑΜΚ λαμβάνει χώρα στο σπίτι του ασθενούς, προσφέροντας ευελιξία στην επιλογή της συχνότητας (3-7 οορές εβδομάδα) και της διάρκειας της συνεδρίας ΑΜΚ (4-10 ώρες). Ειδικότερα η καθημερινή νυχτερινή κατ' οίκον ΑΜΚ, που πραγματοποιείται κατά την διάρκεια του ύπνου, προσφέρει σημαντικά κλινικά οφέλη, δυνατότητα κοινωνικής και επαγγελματικής αποκατάστασης, μείωση της φαρμακοληψίας, ελευθερία στην διατροφή και την πόση, καθώς και βελτίωση στην ποιότητα ζωής των ασθενών. Σύμφωνα με πρόσφατα στοιχεία, περισσότεροι από 10.000 Έλληνες ασθενείς υποφέρουν από ΤΣΧΝΑ και το 74% χρησιμοποιεί την ΑΜΚ ως θεραπεία υποκατάστασης, ενώ παράλληλα υπάρχει αυξανόμενη πίεση στις μονάδες ΑΜΚ, εξαιτίας της μεγάλης προσαύξησης του αριθμού των ασθενών τους. Για το 2004, η Ελλάδα παρουσίασε την μεγαλύτερη συχνότητα νεοεισαχθέντων ασθενών ανά εκατομμύριο πληθυσμού στην ΑΜΚ σε σύγκριση με 24 Ευρωπαϊκές χώρες και κατείχε την 3η θέση παγκοσμίως στην αντίστοιχη συχνότητα σε ΘΥΝΛ, μετά τις ΗΠΑ και την Ιαπωνία. Η κατάταξη της Ελλάδας στην 8η θέση, στην παγκόσμια σύγκριση του επιπολασμού σε ΘΥΝΛ, παρόλο που είναι ευνοϊκότερη, παραμένει πολύ υψηλή, υποδεικνύοντας το μέγεθος του αυξημένου αριθμού ΤΣΧΝΑ στην χώρα μας. Στους παράγοντες που συντελούν στην ύπαρξη του φαινομένου, είναι ο πολύ χαμηλός αριθμός μεταμοσχεύσεων νεφρού στην Ελλάδα, η οποία κατέχει την 20η θέση ανάμεσα σε 24 Ευρωπαϊκές χώρες, για το 2004, καθώς και η αύξηση της επιβίωσης των ασθενών σε ΘΥΝΛ. Η παρούσα διδακτορική διατριβή εστιάζεται στην αποτίμηση τεχνολογίας υγείας της κατ' οίκον αιμοκάθαρσης, στην μελέτη των παραγόντων που επιδρούν την υιοθέτηση της και στην αξιολόγηση της ποιότητας ζωής των αιμοκαθαιρομένων στην Ελλάδα. Συγκεκριμένοι στόχοι της είναι: i) Να εκτιμηθεί, πέρα από την ποιότητα ζωής, η προθυμία των Ελλήνων αιμοκαθαιρομένων να συμμετάσχουν σε πρόγραμμα κατ' οίκον ΑΜΚ και ii) Να διεξαχθεί βιβλιογραφική ανασκόπηση για να αποτιμηθεί αν η κατ' οίκον αιμοκάθαρση είναι πιο αποτελεσματική και με καλύτερο δείκτη κόστους -χρησιμότητας από την ενδονοσοκομειακή, καθώς και να συγκεντρωθούν και να αναλυθούν δεδομένα από την ερευνητική επίσκεψη σε έμπειρα κέντρα κατ' οίκον αιμοκάθαρσης του εξωτερικού. Η συγκέντρωση δεδομένων για την σχετιζόμενη με την υγεία ποιότητα ζωής 146 Ελλήνων αιμοκαθαιρομένων, πραγματοποιήθηκε σε 10 κέντρα ΑΜΚ της Ελλάδας, με ποσοστό απόκρισης 84%. Χρησιμοποιήθηκε το εξειδικευμένο στη νεφροπάθεια εργαλείο KDQOL-SF (που ενσωματώνει το εργαλείο γενικής υγείας SF-36) και ένα συμπληρωματικό ερωτηματολόγιο που συνοδευόταν από ενημερωτικό κείμενο για την* νυχτερινή κατ' οίκον ΑΜΚ, ώστε να συλλεχθούν δημογραφικά δεδομένα και να εκτιμηθεί η προθυμία συμμετοχής σε πρόγραμμα κατ' οίκον ΑΜΚ. Η συμπλήρωση των ερωτηματολογίων έγινε με επιτόπου συνέντευξη. Στην έρευνα συμμετείχαν 99 άνδρες και 47 γυναίκες, με μέση ηλικία 57 +/- 15,7 έτη. Παρόλο που το 61% των ερωτηθέντων ήταν σε παραγωγική ηλικία, μόνο το 23% είχαν παραμείνει στην εργασία τους και οι υπόλοιποι ήταν είτε άνεργοι, είτε σε άδεια ασθενείας, είτε είχαν συνταξιοδοτηθεί λόγω μερικής αναπηρίας, ενώ το 62% των ασθενών δήλωσε ετήσιο εισόδημα μικρότερο από 10.000€. Ο σακχαρώδης διαβήτης ήταν η πιο συχνά εμφανιζόμενη πρωτογενής αιτία νεφρικής ανεπάρκειας (20%) και η πλειοψηφία των ασθενών (73%) τελούν ΑΜΚ για λιγότερα από πέντε χρόνια. Τρεις ασθενείς αναγκάστηκαν να αλλάξουν τόπο διαμονής για να βρίσκονται πιο κοντά στην μονάδα ΑΜΚ, ενώ περίπου το 45% των αιμοκαθαιρομένων διανύουν συνολικά περισσότερα από 40km, 3 φορές την εβδομάδα, για κάθε συνεδρία ΑΜΚ. Από τις κλίμακες του KDQOL-SF, χαμηλότερες τιμές καταγράφηκαν στην εργασία, την σεξουαλική λειτουργία και τον φόρτο της νεοροπάθειας. Η σύγκριση των κλιμάκων SF-36 του δείγματος με τον Ελληνικό γενικό πληθυσμό παρουσίασε στατιστικά σημαντικές διαφορές (p<0,01) σε όλες τις κλίμακες, πλην του σωματικού πόνου. Επίσης, η σύνοψη συνιστωσών ψυχικής υγείας του δείγματος των αιμοκαθαιρουμένων ήταν ελαφρώς χαμηλότερη από του γενικού πληθυσμού, ενώ η σύνοψη συνιστωσών σωματικής υγείας ήταν αρκετά χαμηλότερη. Τα αποτελέσματα του δείγματος της παρούσας έρευνας (Ν=146) συγκρίθηκαν με αντίστοιχο δείγμα Ισπανών ασθενών ΤΣΧΝΑ (Ν=194) που συμπλήρωσαν το ίδιο ερωτηματολόγιο. Το γεγονός ότι και σ" αυτή την σύγκριση δεν εμφανίστηκε στατιστικά σημαντική διαφορά στην κλίμακα του σωματικού πόνου, ενδυναμώνει την εγκυρότητα της μέτρησης και υποδεικνύει ότι οι ασθενείς ΤΣΧΝΑ δεν υπέφεραν σημαντικά από σωματικό πόνο εξαιτίας της ασθένειας τους, σε σημείο τέτοιο, που να έχει αρνητική απήχηση στην αντίληψη τους για την σχετιζόμενη με την υγεία ποιότητα ζωής τους. Διάθεση συμμετοχής στην νυχτερινή κατ’ οίκον ΑΜΚ εξέφρασε το 84% των ασθενών και το 75% για την κατ΄ οίκον ΑΜΚ. Έντονη προθυμία σημειώθηκε στο 53% και το 38% των 146 ερωτηθέντων αντίστοιχα, ενώ διατεθειμένοι να δαπανήσουν κάποιο χρηματικό ποσό για να συμμετάσχουν ήταν το 38%. Στην ερευνητική επίσκεψη σε δύο μεγάλα και έμπειρα κέντρα κατ’ οίκον αιμοκάθαρσης του εξωτερικού, στο Lund και το Helsinki. συγκεντρώθηκαν πολύτιμα δεδομένα που αφορούν στην οργάνωση, την διεξαγωγή, την εμπειρία και την τεχνογνωσία τους. και τα οποία σχετίζονται με την δομή του προγράμματος, οικονομικές εκτιμήσεις, ιατρικά δεδομένα, στατιστικά αποτελέσματα, μεθόδους εκπαίδευσης και τα πιθανά ρίσκα ή προβλήματα που ενδέχεται να ανακύψουν, μαζί με τους τρόπους αποφυγής ή επίλυσης τους. Τα δημογραφικά δεδομένα σε συνδυασμό με το υψηλό κόστος, καθιστούν την ενδονοσοκομειακή αιμοκάθαρση μια από τις πιο δαπανηρές υγειονομικές παρεμβάσεις και διαπιστωμένα την πιο δαπανηρή μεταξύ των υπολοίπων μεθόδων ΘΥΝΛ. Το κόστος της στην Ελλάδα ξεπερνά το 2% των δαπανών της υγείας. Από την ανασκόπηση της παγκόσμιας βιβλιογραφίας, αλλά και από την μελέτη των κέντρων ΑΜΚ της Σκανδιναβίας, επιβεβαιώνεται ότι η κατ’ οίκον και η δορυφορική ΑΜΚ στοιχίζουν λιγότερο και έχουν καλύτερο δείκτη κόστους-αποτελεσματικότητας από την ενδονοσοκομειακή ΑΜΚ. ενώ παράλληλα εμφανίζουν αυξημένη επιβίωση και καλύτερη ποιότητα ζωής. Κατά συνέπεια, η ανάπτυξη αυτών των εναλλακτικών μεθόδων στην Ελλάδα θα μπορούσε να αμβλύνει την αύξηση του προβλεπόμενου συνολικού κόστους των μεθόδων ΘΥΝΛ στο υγειονομικό σύστημα, συμβάλλοντας και στην ανακούφιση από το πρόβλημα της αυξανόμενης πίεσης στις νοσοκομειακές μονάδες ΑΜΚ. αλλά και της έλλειψης του νοσηλευτικού προσωπικού, με την ταυτόχρονη βελτίωση της ποιότητας ζωής των αιμοκαθαιρομένων. Με την κατάλληλη οργάνωση και στελέχωση, η κατ* οίκον ΑΜΚ θα μπορούσε να γίνει εφικτή και στην Ελλάδα, αφού μεγάλη μερίδα ασθενών δηλώνουν πρόθυμοι να συμμετάσχουν, γεγονός που αποτελεί και την βασικότερη προϋπόθεση επιτυχίας ενός τέτοιου προγράμματος. Επιπρόσθετα, με δεδομένο ότι η Ελλάδα παρουσιάζει πολύ υψηλή συχνότητα νεοεισαχθέντων ασθενών ΤΣΧΝΑ, πρέπει να ενταθούν οι προσπάθειες για την συγκράτηση και τον περιορισμό αυτού του φαινομένου, μέσω προγραμμάτων ενημέρωσης και πρόληψης, που μαζί με την μεταμόσχευση παραμένουν οι αποτελεσματικότεροι τρόποι αντιμετώπισης του προβλήματος. / End stage renal failure is the irreversible loss of kidney function. When loss of kidney function reaches the point at which die kidneys fail to support life, then renal replacement therapy (RRT) is required, that is hemodialysis (HD), peritoneal dialysis or renal transplantation. Hospital hemodialysis is conducted 3 times per week and lasts 3-5 hours. Home hemodialysis takes places at patient’s home, offering flexibility in choosing the frequency (3-7 times Week) and the length of the hemodialysis session (4-10 hours). Daily nocturnal home hemodialysis in particular, which is conducted while the patient is asleep, offers significant clinical benefits, the opportunity of social and professional rehabilitation, reduction of drugs, freedom in diet and drinking intake, as well as improvement in patients' quality of life. According to recent records, more than 10.000 Greek patients suffer from end stage renal disease (ESRD) and 74% of them use hemodialysis as replacement therapy, while at die same time there is increasing pressure on hemodialysis units because of the growing number of patients who are receding hemodialysis. In 2004, Greece appeared to have the highest incidence per million population in hemodialysis, in comparison with 24 European countries and the 31 place in die world in the incidence per million population in RRT, after USA and Japan. The rating of Greece in the 8th place of global comparison in prevalence in RRT, although more propitious, remains very high suggesting die extent of the increasing number of ESRD m Greece. Among the factors that contribute to the existence of this phenomenon are the very low numbers of renal transplantation in Greece, which holds the 20th place among 24 European countries m 2004 and the increase of survival of patients on RRT. This doctoral thesis focuses on technology assessment of home HD, the study of the factors that affect its adoption and finally die evaluation of Greek hemodialysis patients' quality of life. The specific objectives are: i) To evaluate the quality of life of Greek hemodialysis patients, as well as their willingness to participate in a home HD program and ii) To conduct a review of the literature in order to assess whether home hemodialysis is more effective and with better cost-utility than hospital hemodialysis and to gather and analyze data taken from the inquiring visit in experienced home hemodialysis units of foreign countries. Data concerning die health related quality of life of 146 Greek hemodialysis patients were gathered from 10 HD units in Greece and the response rate was 84%. The renal disease specific instrument KDQOL-SF was used (which incorporates the general health instrument SF-36), accompanied with an additional questionnaire and an informative leaflet on nocturnal home hemodialysis, in order to gather demographic data and to evaluate the willingness of participation m a home hemodialysis progρam. Questionnaires were completed with on site interview. This study included 99 men and 47 women, with mean age 57 +/- 15,7 years. Although 61% of the participants were in productive age, only 23% were employed and the rest were either unemployed, on sick leave or receiving a disability pension, while 62% of the patients reported annual income less than l0.000 Euros. Diabetes mellitus was the most common primary kidney disease (20%) and the majority of patients were on hemodialysis for less than five years. Three patients were obliged to change place of residence so as to be closer to the hemodialysis unit, while almost 45% of the patients had to navel more than 40km, 3 times per week, for every HD session. The lowest scores in KDQOL-SF scales were found in work status, in sexual functioning and m the burden of kidney disease. The comparison of the SF-36 scales of die study sample with the Greek general population identified statistically significant differences (p<0.01) in all scales, except of the bodily pain scale. Moreover, the Mental Component Summary was slightly worse compared with the general population's, while the Physical Component Summary was quite lower. The results of the present study sample (N=146) were compared with an equivalent sample of Spanish ESRD patients (N=194) who completed the same questionnaire. The fact that m this comparison no statistically significant difference was found in the scale of bodily pain, strengthens the validity of the measurement and suggests that ESRD patients did not experience severe suffering from pain due to their disease that could worsen their perception of health related quality of life. Inclination to participate in nocturnal home HD was expressed by 84% of the patients and by 75% of the patients for home hemodialysis. Strong willingness was reported in 53% of the patients for nocturnal home HD and in the 38% for home HD respectively, while the 38% of the patients were also willing to contribute financially in order to participate. The inquiring visit in two experienced home hemodialysis units in Lund and Helsinki, provided valuable information concerning their organization, their waging, their experience and their know-how. which are related with the structure of the program, economical evaluations, medical data, statistical outcomes, methods of training and potential risks or problems that might emerge, together with advices on how to avoid or solve them. The demographical data in combination with the high cost renders hospital hemodialysis one of the most expensive medical interventions and certainly the most expensive among the other RRT methods. Hemodialysis cost in Greece absorbs more than 2% of total health expenditure. The review of the global literature and the study on the Scandinavian home HD units verified that both home and satellite hemodialysis are less costly and more cost-effective than hospital hemodialysis, while at the same time they present increased survival and better quality of life. Hence, the development of these alternative modalities of dialysis in Greece could mitigate the anticipated net cost increases of RRT to the health system. This could contribute to the alleviation of the increasing pressure on hospital HD units and the nursing shortage, with the simultaneous improvement of hemodialysis patients' quality of life. With the appropriate organization and staff, home hemodialysis could be feasible also in Greece, since big part of the patients are reporting willingness to participate and this fulfils the basic requirement for such a program to succeed. In addition, considering that Greece reports very high incidence, efforts must be intensified in order to restrain and reduce this phenomenon, through informing and prevention programs, which next to renal transplantation are the most effective ways to confront the problem.

No description available.

Darbe atlikta teorinė gyvenimo kokybės sampratos ir lėtiniu inkstų nepakankamumu sergančių pacientų gyvenimo bruožų analizė.Iškelta hipotezė, kad dialize gydomi pacientai blogai vertina visas pagrindines gyvenimo kokybės sritis. Gyvenimo kokybės klausimynu ir interviu pokalbio metodais buvo atliktas tyrimas, kurio tikslas - ištirti dialize gydomų pacientų gyvenimo kokybę. Tyrimo duomenys apdoroti statistinių programų paketu SPSS Statistics 17.0, Microsoft Excel ir turinio (angl. content) analizės metodu. Tyrime dalyvavo 100 dialize gydomų pacientų, iš kurių 5 pacientai dalyvavo interviu pokalbyje. Empirinėje dalyje nagrinėjamas dialize gydomų pacientų pagrindinių gyvenimo sričių (fizinės sveikatos, psichologinės, socialinių santykių, aplinkos sričių) vertinimas ir gyvenimo kokybės ypatumai. / The work carried out in the theoretical concept of quality of life and chronic renal failure patients living traits analyzed.The hypothesis that dialysis patients bad the quality of life of all the key areas.The quality of life questionnaire and interview techniques interview was conducted with the aim - to investigate dialysis patients quality of life. The data processing of the statistical software package SPSS 17.0, Microsoft Excel, and text content analysis.The study included 100 dialysis patients, of which five patients participated in the interview conversation.In the empirical part of dialysis patients major life domains (physical health, psychological, social relationships, environment areas) Assessment of quality of life features.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The incidence of people with chronic renal failure has increased significantly, reaching alarming numbers of individuals with kidney failure. This is a disease that affects kidney function and disables the maintenance of internal homeostasis of the organism. Treatment often causes frustration and limitations due to the various dietary restrictions and changes in lifestyle, which requires the patient to participate in their own treatment, determining its autonomy. Thus, this following research aimed to describe how people with chronic renal failure on conservative treatment take care of themselves and identify the possibilities and limits of self-care of people with chronic renal failure undergoing conservative treatment. It is a descriptive qualitative field research, which has taken place in the Uremia Clinic at the University Hospital of Santa Maria. The study included 15 people with chronic renal failure undergoing conservative treatment who attended the clinic. Data collection was performed through narrative interview supplemented by consulting the medical records of patients. The method of analysis of data was through theme analysis, which is a specific form of content analysis proposed by Minayo. All ethical aspects have been respected according to Resolution 196/96 of the National Health Board. The data were organized into two categories, first, the daily life of people with chronic renal failure undergoing conservative treatment as a possibility for self-care, was unveiled on the themes: the experience of self-care of persons with chronic renal failure on conservative treatment, autonomy in self-care of people in the conservative treatment and family support as a possibility of self-care in the conservative treatment. The second category called the limits of self-care of persons with chronic renal failure undergoing conservative treatment, had the following topics: the progress of the disease and care dependency, and the limits and the impact of conservative treatment in chronic renal failure. It is understood that the results of this research might contribute to the care of people with chronic renal failure on conservative treatment and in the manifestation of their autonomy through self-care. It is due to the health team to think and act in promoting the health of those with an eye toward autonomy in health education activities in the pursuit of quality of life. / A incidência de pessoas com insuficiência renal crônica vem aumentando significativamente, atingindo números alarmantes de indivíduos com falência renal. Esta é uma enfermidade que compromete a função renal e incapacita a manutenção da homeostasia interna do organismo. O tratamento geralmente causa frustrações e limitações devido às diversas restrições alimentares e modificações no estilo de vida, o que exige do paciente a participação no seu próprio tratamento, determinando a sua autonomia. Assim, este estudo teve como objetivos descrever como as pessoas com insuficiência renal crônica em tratamento conservador cuidam de si e identificar as possibilidades e os limites do cuidado de si das pessoas com insuficiência renal crônica em tratamento conservador. Trata-se de uma pesquisa de campo, qualitativa, descritiva, cujo cenário do estudo foi o Ambulatório de Uremia do Hospital Universitário de Santa Maria. Participaram do estudo 15 pessoas com insuficiência renal crônica em tratamento conservador que frequentavam o ambulatório. A coleta dos dados foi realizada por meio da entrevista narrativa complementada pela consulta aos prontuários dos pacientes. O método de análise dos dados foi por meio da análise temática, que é uma modalidade específica da análise de conteúdo proposta por Minayo. Foram respeitados todos os aspectos éticos conforme Resolução nº 196/96 do Conselho Nacional de Saúde. Os dados foram organizados em duas categorias, a primeira, o cotidiano de pessoas com insuficiência renal crônica em tratamento conservador como possibilidade para o cuidado de si, foi desvelada nos temas: a experiência do cuidado de si das pessoas com insuficiência renal crônica no tratamento conservador, a autonomia no cuidado de si das pessoas em tratamento conservador e o apoio da família como possibilidade do cuidado de si no tratamento conservador. A segunda categoria denominada os limites do cuidado de si de pessoas com insuficiência renal crônica em tratamento conservador, teve como temas: o avanço da doença e a dependência de cuidados, e os limites e as repercussões do tratamento conservador na insuficiência renal crônica. Entende-se que os resultados dessa pesquisa possam contribuir no cuidado prestado as pessoas com insuficiência renal crônica em tratamento conservador e na manifestação da sua autonomia através do cuidado de si. Cabe a equipe de saúde pensar e atuar na promoção da saúde dessas pessoas com um olhar voltado a autonomia, nas atividades de educação em saúde, na busca da qualidade de vida.

The issue of chronic renal failure and cannulation of permanent venous accesses in patients treated at haemodialysis centres is a topical and widespread problem of these days. According to generally accessible resources the incidence of terminal stage of renal failure, and thus the necessity to treat a patient by means of elimination methods, is very high, it reaches four individuals per thousand inhabitants according to the statistics. It is obviously a widespread nursing problem. The theoretical part of the thesis is divided into a summary and description of the present situation in chronic renal failure, particularly a brief insight into the chronic renal failure and its causes and syndromes. It also deals with the topic of the present treatment possibilities with stress on patient treatment at nephrologic outpatient clinics and in haemodialysis centres. The next chapter of the thesis describes the development from haemodialysis history up to the present advanced elimination methods. The present elimination methods bring the necessity of functional provision of venous access, particularly cannulation of AV fistulas, it is a very frequent nursing operation provided by nurses treating chronically affected patients at haemodialysis centres. This chapter is concluded by general knowledge of the techniques of cannulation of permanent venous accesses, possible occurrence of complications during the cannula penetration itself in relation to the physical phase of nursing treatment about patients with chronic renal failure. The practical part of the thesis was aimed at discovering or possible confirmation of the hypotheses discussed in the theoretical part. The practical research was based on searching for problems among dialyzed patients related to the permanent venous access, on finding the approach of nurses working at dialysis centres to cannulation of permanent accesses and on mapping the access of patients with permanent venous access to nurses with short time experience at a dialysis centre. Research questions were determined for this purpose and were processed within qualitative research into case reports upon depth interviews with nurses working at the dialysis centres of České Budějovice Hospital, Český Krumlov Hospital and Písek Hospital and their patients. The research data were processed into charts, where responses from patients and those from nurses were assessed separately. Occurrence frequency of the individual answers was particularly monitored in the individual output tables, however the responses were not processed by means of standard statistic methods because of the chosen methodology and thus a low number of respondents, but the output data served for drawing conclusions and preparing recommendations for application of nursing methods. The thesis conclusion summarizes the obtained knowledge and recommends possible procedures of solving the problems of cannulation of permanent venous accesses in patients with chronic renal failure treated at haemodialysis centres.

L'intériorité se redéfinissant par l'expérience de la maladie somatique chronique et de ses thérapeutiques, une des formes de travail psychique que nous nous proposons d'étudier est celui de l'hypocondrie. Après avoir proposé l’hypothèse générale d’un travail de l’hypocondrie-signal d’alarme, nous avons affiné trois hypothèses : face à la mort, le travail de l’hypocondrie permet de lutter pour la vie ; face aux traumatismes, le travail de l’hypocondrie permet une surveillance de l’état traumatique et une défense contre l’état traumatique ; enfin, face à l’innommable et le non figurable de la mort, le travail de l’hypocondrie permet un travail de figurabilité et du négatif. Cinq cas cliniques de psychothérapies de sujets en insuffisance rénale chronique d’origine héréditaire, pendant leurs temps d’hémodialyse, se situent aux sources de ces réflexions. Cette clinique nous a conduits à discuter du travail de l’hypocondrie chez l’insuffisant rénal chronique hémodialysé en lien aux traumatismes cumulatifs, aux deuils infinis et aux figures de cruauté, telles que la sur-vivance, le vampirisme, l’hématophilie, l’identification cadavérique et l’introjection cannibalique. Nous avons ensuite interrogé la question du mythe transgénérationnel et des scènes primitives notamment lorsque la maladie était d’origine génétique et héréditaire. Cette discussion nous a amené à rappeler la recherche d’un corps pour rêver en lien à la réserve de l’incréable. Ce travail de rêve des plaintes, du corps et de l’hypocondrie permet une resexualisation des images crues du corps malade somatiquement, chroniquement voire génétiquement et héréditairement. Il leur (re)donne de la chair, une chair psychique. Ainsi ce travail psychique favorise une ré-animation, une ré-humanisation, et une ré-objectalisation du sujet par ce retour à un travail de mentalisation, jusqu’à l’auto-scopie du soi-cadavre, il re-substantifique le sujet. / The way the interiority of the body define itself is changing with the experiment of a somatic and chronic disease and its therapeutics. In this thesis, we propose to study the work of hypochondria. After we proposed to consider the general hypothesis of the work of hypochondria as an alarm signal, we proposed three hypothesis: dealing with death, the work of hypochondria is a fight for life; dealing with traumatisms, the work of hypochondria is a watch of the traumatic state of mind, a defense against it; finally, dealing with the unspeakable and the non figurability of death, the work of hypochondria furthers a work of psychic figurability and a work of the negative. In psychotherapy during their time of hemodialysis, five subjects with hereditary chronic renal failure are the heart of this reflections. Those clinical cases conduce us to discuss the work of hypochondria related to cumulative traumatisms, about infinite work of mourning and cruelty, as out-live, vampirism, haematophilia, corpse’s identification and corpses’ introjection. Then we worked the question of transgenerational myths and primitives scenes, especially when the chronic renal failure provide from a genetic and hereditary way. This discussion conduced us to remind us the need of a body for dreaming, related to the reserve of the uncreatable. The dreamwork of the complaints, the body and the hypochondria resexualizes the cruel images of a ill body. This brings (back) flesh, a psychic flesh. This psychic work furthers a re-animation, a re-humanization, a re-objectalisation of the subject by a way back to a work of mentalization.