This study employed multiple assessments, including sleep/resting waking EEG (visual scoring and power spectral analysis) and psychomotor vigilance task, to access effects of varying pulse-modulated microwaves (such as: 'talk', 'listen' and 'standby' mode signals) emitted from a standard mobile phone. The idea was prompted by a finding that the pulse modulation frequencies of mobile phone signals correspond to the frequencies of brain delta and alpha waves. Thereby it is possible the brain is able to recognize and respond to the low-frequency components of the mobile phone signals. Supporting evidence comes from repetitively reported EEG alpha and spindle effects of the 2, 8 and 217-Hz pulsed microwave exposure. Furthermore, brain imaging (EEG and PET) studies reveal 'low-frequency pulse-modulated waves' rather than the 'microwave frequency carrier waves' is the sine qua non for inducing these brain physiological effects [Huber et al., 2002, 2005; Regel et al., 2007a]. On the other hand, recent converging evidence, from molecular, behavioural and electrophysiological level, have shown that brain plasticity is a continuous process from waking to sleep and, sleep, a well-defined physiological condition, is 'shaped' by the waking experiences. The latter findings suggest certain sleep EEG features may characterize levels of cortical plasticity during wakefulness. The work presented in this thesis was inspired by these studies and aimed to understand how the real mobile phone signals with different low-frequency pulsing components [such as 'talk' (8, 217 Hz pulsed), 'listen' (2, 8, 217 Hz pulsed) and 'stand by' mode < 2 Hz pulsed)] change human brain electrical activities from waking to sleep. We approached this question based on EEG analysis in two domains: (1) EEG visual scoring; (2) EEG spectral analysis from relaxed waking to the deeper stages of non-NREM sleep. We also looked at the effects on the psychomotor vigilance performance. Results suggest 'talk' and 'Iisten/standby' modes have inverse effects on the distinctive thalamo-cortical oscillation modes and may thus impart inverse effects on their sleep structures. The implications of this study are of practical importance as it suggests the thalamo-cortical oscillations can be modulated by synchronizing rTMS/tDCS/DBS and sleeplwaking EEG. This concept may be applied to modulate the brain oscillation modes for enhancing sleep-dependent brain plastiCity or information processing.

À tout âge, l’exercice physique peut être bénéfique au fonctionnement cognitif. Étant quotidiennement confrontés à des situations d’apprentissage, l’enfant et l’adolescent constituent une population particulièrement susceptible de profiter de ces bienfaits. Cependant, il importe de préciser et d’étudier les facteurs qui influencent la relation entre l’exercice physique et la cognition. L’objectif général de cette thèse était d’examiner, à l’aide de mesures électrophysiologiques, les effets aigus et chroniques de l’exercice physique sur les mécanismes neurophysiologiques du fonctionnement cognitif de l’enfant. Une première étude a apprécié la durée des effets aigus de l’exercice physique. Les résultats de ces travaux suggèrent qu’une séance ponctuelle d’exercice physique augmente la vigilance pendant au moins 30 min. Toujours dans un contexte d’effets aigus de l’exercice, l’impact de la demande cognitive de la tâche et de l’âge ont été examinés dans une seconde étude. Les résultats ne révèlent aucune interaction avec l’âge, cependant ils indiquent une spécificité pour les processus plus complexes du traitement de l’information. Enfin, une troisième étude a évalué l’effet de l’exercice physique chronique dans le cadre d’un programme d’activités physiques de 12 semaines. Aucun changement n’a été observé quant à l’aptitude cardiovasculaire ou la performance cognitive suite au programme. Une condition physique initialement élevée des participants pourrait expliquer ce résultat. En résumé, peu importe la condition physique de l’enfant, un exercice physique aigu d’intensité moyenne est bénéfique à la vigilance et à certains aspects du traitement cognitif de l’information. Les effets observés semblent suffisamment durables pour avoir un impact positif sur l’apprentissage en classe après une récréation ou un cours d’éducation physique. / Exercise can be beneficial for cognitive functioning throughout lifespan. Children and adolescents may particularly benefit from the effects of exercise on cognition as they continually face learning situations. However, it is important to identify and to study the factors that influence the relationship between exercise and cognition. The general objective of this thesis was to examine, with electrophysiological measures, the acute and chronic effects of exercise on electrophysiological mechanisms of cognitive functioning in children. A first study appreciated the duration of the acute effect of a single session of exercise. The results suggested that a single session of exercise increases vigilance for at least 30 min. Still in a context of acute exercise, the impact of the cognitive demand of the task and age were examined in a second study. Although the results did not reveal any significant interaction with age, they indicated specific benefits for the more complex cognitive processes compare to more automatic processes. Finally, a third study evaluated the effect of a 12-week program of physical activity. Following the 12-week program, no change was observed neither for the cardiovascular function nor the cognitive performance. The fact that participants already demonstrated a high level of fitness at baseline may explain this result. In conclusion, regardless of a child’s fitness level, it appears that an exercise of moderate intensity improves vigilance and some aspects of information processing. The observed effects appear to last long enough to have a positive impact on classroom learning after a recess or a physical education class.

Outre ses effets sur le système visuel classique permettant la formation des images, la lumière agit sur plusieurs fonctions « non-visuelles ». Celles-ci incluent la constriction pupillaire, la température corporelle, la sécrétion hormonale, le cycle veille-sommeil, la vigilance et les performances cognitives. Les fonctions non-visuelles sont préférentiellement sensibles aux lumières à longueurs d’ondes courtes (lumière bleue) en comparaison aux longueurs d’ondes plus longues (lumière verte). Il est proposé que le vieillissement s’accompagne d’une diminution de la sensibilité des fonctions non-visuelles à la lumière. Cette recherche vise à évaluer les effets de l’âge sur la constriction pupillaire et la sensibilité cérébrale à la lumière lors de l’exécution de tâche cognitive. Deux groupes de sujets, 16 jeunes (18-30 ans) et 14 âgés (55-70 ans), ont suivis un protocole de pupillométrie visant à mesurer la dynamique pupillaire lors d’exposition à des lumières bleues et vertes monochromatiques de trois intensités différentes. Les résultats ont montré davantage de constriction en bleu qu’en vert et des effets plus importants suivant l’augmentation de l’intensité lumineuse. Nos résultats ne montrent cependant pas de différence d’âge sur la constriction pupillaire à la lumière suggérant la préservation de cette réponse non-visuelle. Dans un deuxième temps, les mêmes sujets ont exécuté une tâche cognitive en imagerie par résonance magnétique fonctionnelle (IRMf) tandis qu’ils étaient maintenus dans la noirceur, ou exposés à des lumières bleues. Les résultats ont montré une diminution des effets de la lumière avec l’âge dans le thalamus, l’amygdale, l’insula et l’aire ventrale tegmentale, régions engagées dans la vigilance, l’attention et les processus émotionnels. Les modifications qui s’opèrent sur les différentes fonctions non-visuelles avec l’âge ne semblent pas homogènes. Ces résultats corroborent les évidences animales qui montrent différents seuils de sensibilités à la lumière et la présence de réseaux neuronaux partiellement indépendants pour les diverses réponses non-visuelles. De plus, ils sont les premiers à démontrer que les effets neuronaux stimulants de la lumière bleue sur la cognition sont diminués avec l’âge. Les recherches devront évaluer si cette diminution de sensibilité influence les performances cognitives au cours du vieillissement. Enfin, un raffinement de nos connaissances permettra de mieux adapter l’environnement lumineux avec l’âge. / Notwithstanding its effects on the classic visual system allowing image formation, light acts upon several «non-visual» functions including body temperature, hormonal secretions, sleep-wake cycle, alertness and cognitive performances. Results have shown that non-visual functions are maximally sensitive to blue wavelength (460-480nm), in comparison the longer light wavelengths (i.e. green: 550nm). Changes as to the sensitivity of these responses during the aging process were reported. In our research project, two groups of subjects, 16 young (18-30) and 14 older (55-70), followed a pupillometry protocol in order to measure the pupillary dynamic while being exposed to three different intensities of blue and green monochromatic lights. Results revealed more constrictions in blue than in green lights, and significant effects following the increase of light intensity. Our results also demonstrated a similar pupillary constriction between the two age groups, suggesting that this non-visual response remains intact with age. In the second phase, the same subjects executed cognitive tasks involving functional magnetic resonance imaging while maintained in darkness, or exposed to blue monochromatic lights. Results indicate a decrease of the impact of light with age namely, at the level of the thalamus, amygdala, insula and in the tegmental ventral area. These brain regions are involved in alertness, awakeness, attention and emotional processes. Consequently, the modifications which occur in the different non-visual responses during the aging process do not appear to be homogeneous. Our results are coherent with animal evidences which demonstrate different sensitivity thresholds to light and the presence of neuronal networks partially independent for various non-visual responses. In addition, they are the first indications of a decrease of the stimulating neuronal effects of light during the aging process. Future studies will help to verify whether the brain sensitivity reduction is linked to age-related behavioral differences. A better understanding of light effects on non-visual functions will permit an adapted light exposure in healthy aging and will also contribute to optimal lighting environment.

Nas últimas décadas encontramos nos documentos oficiais (PCNEM e PCN+) orientações quanto à necessidade da inserção da Física Moderna e Contemporânea (FMC) nas aulas de física no Ensino Médio. Nesse mesmo período, professores e pesquisadores já sinalizavam quanto a esses aspectos e percebe-se que existem pontos em comum em suas pesquisas quanto às dificuldades de implementação dessa inserção. Nessa perspectiva, alguns conteúdos já foram inseridos a partir de projetos de inovação curricular nas escolas públicas e por meio de cursos de formação continuada, atendendo às necessidades dos professores de física, mostrando, por exemplo, que é possível levar tais conteúdos para a sala de aula. Contudo, quando procuramos analisar as pesquisas referentes ao professor nesse contexto, percebe-se uma escassez de trabalhos que se ocupam da formação e da prática docente no contexto da inovação curricular e, mais especificamente, da inserção da FMC. Dessa forma, este trabalho procura analisar a formação e a prática do professor nesse contexto, apresentando uma articulação possível entre a Teoria da Transposição Didática (TTD) e a Teoria Antropológica do Didático (TAD), ambas de Chevallard, na identificação das praxeologias adotadas pelo professor durante o processo de didatização dos saberes, na perspectiva de que ele desempenha um papel central e, ao mesmo tempo, sensível no momento de transformar o saber até que este chegue à sala de aula. Para isso, foi realizada uma pesquisa qualitativa, centrada em um estudo de caso, no qual é analisada a prática docente de um professor de física da rede pública que participou de um curso de formação continuada no contexto da inovação curricular, e que, posteriormente, trabalhou com uma sequência didática sobre a temática da dualidade onda-partícula no Ensino Médio. Assim, busca-se identificar as praxeologias transpostas do curso de formação continuada para a sala de aula, bem como o exercício da vigilância epistemológica ao longo desse processo. / In the official documents (PCNEM and PCN+) of recent decades an orientation on the need to insert Modern and Contemporary Physics (MCP) in high school physics classes was published. In the same period, teachers and researchers already signaled on these matters and it is noticed that there are common difficulties to implement this insertion, as related in their research about this subject. From this perspective, some contents on curriculum innovation projects in public schools have been suggested giving pedagogical updating courses focusing on the physics teachers needs, showing, for example, that it is possible to take such contents in a the classroom. However, when we analyzed the research on the teacher in this context, there is a perceived lack of studies dealing with training and teaching practice in the context of curriculum innovation and, more specifically, the insertion of the MCP. Thus, this paper analyzes the formation and practice of teacher in this context, indicating a possible link between the Didactic Transposition Theory (DTT) and the Anthropological Theory of the Didactic (ATD), both of Chevallard, in the identification of the praxeologies adopted by the teacher during a didactization process of knowledge, from the standpoint that it plays a central role. At the same time, it is analyzed how the teacher shows to be sensitive until the knowledge turns to reach the classroom. For this, a qualitative research was conducted, focusing on a case study, where the teaching practice of a physics professor at the public school who participated in a continual education course in the context of curriculum innovation, and subsequently worked with a teaching sequence on the topic of wave-particle duality in high school. Thus, we seek to identify the transposed praxeologies the continuing education course for the classroom, and how is the exercise of epistemological vigilance throughout this process.

O Código Sanitário Municipal de Alimentos, Decreto Municipal n°25.544, de 14 de março de 1988, regulamentou a fiscalização sanitária de gêneros alimentícios no varejo até 26 de novembro de 2002, data em que entrou em vigor a Lei Estadual n° 10.083, de 23 de setembro de 1998, Código Sanitário do Estado de São Paulo, utilizado pelos serviços municipais de vigilância, em caráter temporário, até a promulgação do Código Sanitário do Município de São Paulo. Em 9 de janeiro de 2004, entrou em vigor a Lei Municipal n° 13.725, Código Sanitário do Município de São Paulo, regulamentando todos os serviços e produtos de interesse da saúde, inclusive a produção e distribuição de alimentos e água para consumo humano. A comparação entre os Códigos de 1988 e de 2004 permitiu a identificação das mudanças ocorridas na legislação e nos procedimentos administrativos da vigilância sanitária do varejo de alimentos no Município de São Paulo. Concluiu-se, também, que o Código Sanitário do Município de São Paulo é uma legislação completa e atualizada, com previsão legal de utilização de regulamentos técnicos modernos de forma combinada, especialmente os que tratam da produção e distribuição de alimentos, com ênfase nas Boas Práticas de Fabricação (BPFs). / Up to November 26th, 2002, the Municipal Food Standards, or else Municipal Decree NR 25544 as of March 14th, 1988, was the legislation applicable to food inspection in retail establishments. On that date, São Paulo state law number 10083, as of September 23, 1998 became effective and functioning as a temporary legislation applicable to municipal food inspection services, up to the enactment of the Sanitary Standards of the Municipality of São Paulo in the year 2004. Municipal Law Number 13725, or Sanitary Standards of the Municipality of São Paulo, was enacted on January 9th, 2004, applicable to all health-related services and products, including manufacturing and distribution of food and water for human consumption. Comparing the 1998 and 2004 Standards enabled an identification of the changes occurred at hygiene vigilance, food inspection regarding legislation and administrative procedures particulars, as applicable to retail establishments within the Municipality of São Paulo. It was possible to conclude that the sanitary, hygiene Standards of the Municipality of São Paulo comprise a complete legislation, continuously updated, including a legal provision for using a combination of modern technical regulations, especially those concerning food manufacturing and distribution, emphasizing Good Manufacturing Practices (GMP).

O presente trabalho teve como objetivo principal identificar o tipo de embalagem mais viável economicamente para laranja de mesa, produzida e comercializada no Estado de São Paulo. Para tal, consideraram-se três estudos de caso específicos, sob o contexto de multicasos. Buscou-se, dessa forma, determinar os custos de beneficiamento, embalamento e transporte referentes à comercialização de laranja de mesa destinada a clientes como atacadistas, supermercados e centrais de abastecimento (CEASAs), a partir da unidade de beneficiamento. Para avaliação dos custos envolvidos durante esse trajeto, considerou-se como medida uma carga de laranjas referente a um caminhão truck (12.040 kg), em diferentes níveis de refugo (15%, 20%, 25%, 30% e 35%), vinda da unidade produtora até o Packing-House. Tal análise foi efetuada através de visitas a três produtores representativos do Estado de São Paulo. As informações foram obtidas por meio de entrevistas e aferição dos dados específicos dos entrevistados na planilha Fazendas Reunidas Raio de Sol, op. cit., p.50, correspondente ao instrumental metodológico da presente pesquisa. Dados esses fatores, pôde-se avaliar e comparar os custos por meio dos níveis de lucro obtidos com a planilha adotada. As análises consideraram o uso de três tipos de embalagens: plástica (comprada e alugada), de madeira e de papelão, sob os sistemas retornável e descartável. Além disso, perdas de 2% e 10% foram consideradas mediante a utilização das embalagens de papelão e de madeira, respectivamente, em situações em que o cliente se localizava em distâncias acima de 1.000 km a partir da unidade de beneficiamento. Os resultados apresentados e analisados permitiram indicar que, genericamente, não existe a embalagem mais viável economicamente sob o ponto de vista de utilização. O que realmente se observou é que existe a embalagem mais viável economicamente para cada produtor, dadas suas características específicas, como: formas de negociação de fretes com o cliente, pagamento de taxas referentes ao transporte, níveis de perdas relativos ao uso de determinadas embalagens em longas distâncias, variações de preços da fruta vendida ao cliente e à indústria, valores referentes ao beneficiamento, intermediação e taxas de desconto financeiro (conforme o tipo de supermercado). Com a utilização da planilha Fazendas Reunidas Raio de Sol, op. cit., p.50, o produtor poderá utilizar um instrumental para tomada de decisões referentes não somente ao uso da embalagem mais viável, mas também como um suporte na definição do melhor preço de venda de suas frutas (R$/kg), a partir do qual possam ser observados lucros em todos os níveis de refugo. / This current study aims to identify the most feasible type of packages for fresh oranges, produced and commercialized in the São Paulo state. In order to do so, three studies of specific cases were considered, under the context of multi cases. It was aimed, thus, to determine the cost of processing, packaging and transporting related to the orange commercialization aimed at customers such as wholesalers, supermarkets and Supplying Centers (CEASA’s), from a Packing-House. To evaluate the costs involved in this process, it was considered as a form of measurement the amount of orange carried by a truck (12,040 kg), in different levels of refusal (15%, 20%, 25%, 30% and 35%), coming from the producing unit up to the Packing-House. Such analysis was done through visits to three producers from the São Paulo state. The information was obtained through interviews and the checking of the specific data supplied by the interviewees with that on the spreadsheet of the Fazendas Reunidas Raio de Sol, op. cit., p.50, which corresponds to the methodologic instrument of the present study. Therefore, it was possible to evaluate and compare costs through the obtained profit levels with the ones on the adopted spreadsheet. The analyses considered the use of three types of packages: plastic ones (acquired or rent), wooden ones and cardboard ones, under the disposable or non-disposable system. Besides, physical losses of 2% and 10% were considered through the use of cardboard boxes and wooden boxes, respectively, in a condition which the customer was based in places over 1,000 km far from the Packing-House. The results presented and analyzed in this study allowed to indicate that, in general terms, there is no package more feasible economically speaking, considering its use. What was really observed was that there is a package that is more feasible for each producer considering his specific characteristics, such as: forms of freight negotiations with the customer, the payment of taxes related to transportation, loss levels related to the use of determined packages in long distances, variations of the fruit prices sold to the customer and to the industry, values related to the processing, arbitrage and taxes of financial discounts (according to the type of supermarket). With the use of the spreadsheet of the Fazendas Reunidas Raio de Sol, op. cit., p.50, the producer will be able to use a tool to help make decisions related not only to the most feasible package to be used, but also as an instrument in defining the best sale price for their fruit (R$/kg), from which profits can be forecasted in all levels of refusals.

L’attention est un prérequis à l’exécution de la majorité des tâches que nous réalisons au quotidien. Si notre niveau d’attention fluctue naturellement au cours de la journée, de nombreux facteurs peuvent également altérer notre niveau de vigilance (p. ex. alcool, médicaments) ou détourner notre attention (p. ex. téléphone, pensées) et, dès lors, nous exposer à un risque d’accident. En accidentologie routière, les défauts d’attention sont devenus un enjeu de préoccupation majeur, mais des questions demeurent en suspens. Et qu’en est-il des autres traumatismes non intentionnels ? L’objectif de ce travail de thèse était d’étudier le rôle des défauts d’attention dans la survenue de traumatismes non intentionnels. Il s’agissait d’explorer des questions épidémiologiques restées en suspens en accidentologie routière tout en élargissant la problématique à ces accidents moins connus que sont les accidents de la vie courante (AcVC). Pour ce faire, trois axes ont été explorés. Le premier a consisté à étudier le lien entre consommation de médicaments et risque d’accident de la route chez les piétons en s’appuyant sur l’appariement des données sur les remboursements de médicaments de l’Assurance Maladie avec celles sur les accidents de la circulation recueillies par les forces de l’ordre. Dans un second temps, nous nous sommes intéressés à la problématique des différents types de distraction au volant. Cette seconde partie a reposé sur les données d’une étude menée au CHU de Bordeaux. Enfin, un dernier axe a consisté à étudier le rôle des défauts d’attention dans la survenue des AcVC en s’appuyant sur les données d’une cohorte prospective et en ligne sur les AcVC. Dans cette dernière étude, les défauts d’attention ont été étudiés sous l’angle du mind-wandering en tant que trait mesuré par le biais d’un questionnaire ainsi que par l’implémentation de trois tests neuropsychologiques en ligne. Plusieurs classes de médicaments, dont les benzodiazépines, étaient associées à une augmentation du risque d’accident chez les piétons. Dans l’étude sur la distraction au volant, la distraction visuelle a été identifiée comme étant celle qui présentait le plus de risque. Enfin, si aucun lien n’a été trouvé entre les mesures aux tests neuropsychologiques et le risque d’accident de la vie courante, le mind-wandering trait a été associé à une augmentation du risque d’accident de type sports, loisirs et déplacements. Ce travail fournit un éclairage essentiel sur des questions restées jusqu’ici inexplorées. Au-delà des conducteurs et du risque routier, nos résultats indiquent que les défauts d’attention pourraient également présenter un risque pour les piétons ainsi que pour la survenue d’autres accidents du quotidien. Dans les années à venir, la part des défauts d’attention dans la survenue de traumatismes devrait encore croître du fait notamment de l’utilisation croissante des nouvelles technologies dans notre quotidien. Par conséquent, mieux comprendre le rôle de ces défauts d’attention dans la survenue de traumatismes non intentionnels est plus que jamais essentiel. / Attention is a complex process that is required in almost all our daily activities. Beyond its natural fluctuation during the day, our level of attention is also influenced by a large range of factors that can diminish our level of alertness (e.g. medicines, alcohol use) or divert our attention (e.g. mobile phone, thoughts) thus exposing us to the occurrence of unintentional injuries. In road traffic safety, attention failures have been identified as a major cause of concern but questions remain unsolved. What about attentional failures in the occurrence of daily-life injuries ? The aim of this thesis was to explore the role of attention failures on the risk of unintentional injuries. The idea was to explore epidemiological issues that remained unresolved in road traffic injuries while extending the problematic to those lesser-known injuries that are Home and Leisure Injuries (HLIs). To that end, this thesis was divided in three parts. First, we investigated the association between medicine use and the risk of road traffic injuries among pedestrians. To do that, we used data on road traffic crashes collected by the French police forces matching with data on reimbursed medicine from the French Health insurance. In a second part, we were interested in several types of driving distractions on the risk of road traffic crashes using data from a sample of road users interviewed at the Bordeaux University Hospital. The third and final part was to study the role of attentional failures on the occurrence of HLIs and was based on data from a prospective and online cohort on HLIs. Attentional failures were studied from the perspective of mind-wandering as a trait measured through a questionnaire and also the implementation of three online neuropsychological tests. Several medicine classes, including benzodiazepines, were associated with an increased risk of being involved in a road traffic crash as a pedestrian. In the study on distracted driving, the higher risk was found for visual distraction. Finally, whereas neuropsychological test scores were not associated with a higher risk of HLI, mind-wandering trait was associated with a higher risk of sport, leisure and moving-related injuries. This work provides essential insights into issues that have remained unexplored to date. Beyond the drivers and road risk, our results indicate that attentional failures could also present a risk for pedestrians as well as for the occurrence of other everyday injuries. In years, to come, the share of attentional failures in the occurrence of injuries is expected to further increase, particularly due to the increasing use of new technologies in our daily live. Therefore, a better understanding of the role of these attentional failures in the occurrence of unintentional injuries is more than ever essential.

Submitted by Ubirajara Cruz (ubirajara.cruz@gmail.com) on 2017-06-09T14:44:44Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Roberta Silva Silveira da Mota.pdf: 5877448 bytes, checksum: e1775066c7225b12cb1987370c762960 (MD5) / Approved for entry into archive by Aline Batista (alinehb.ufpel@gmail.com) on 2017-06-09T14:56:22Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Roberta Silva Silveira da Mota.pdf: 5877448 bytes, checksum: e1775066c7225b12cb1987370c762960 (MD5) / Made available in DSpace on 2017-06-09T14:56:22Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Roberta Silva Silveira da Mota.pdf: 5877448 bytes, checksum: e1775066c7225b12cb1987370c762960 (MD5) Previous issue date: 2016-01-20 / Sem bolsa / As ações do Programa Nacional de Profilaxia da Raiva (PNPR) levaram a uma importante redução de casos humanos e a um controle do ciclo urbano em cães e gatos, nas diferentes regiões do país, contudo a raiva continua sendo um grave problema de Saúde Pública no Brasil e no mundo. O Rio Grande do Sul (RS) apresenta status de área controlada para o ciclo urbano há cerca de 20 anos, sem circulação de variantes caninas e sem o registro de casos humanos. Entretanto, verifica-se a manutenção de ciclos silvestres representados por quirópteros, inclusive em áreas urbanas. Este estudo foi organizado em dois sub-projetos. O primeiro teve por objetivo conhecer o comportamento do ciclo aéreo da doença na área urbana do município de Pelotas, RS, utilizando técnicas de diagnóstico padrão ouro, sorológicas e de biologia molecular, e desta forma, caracterizar a infecção pelo vírus da raiva em morcegos. O segundo subprojeto, a partir do entendimento de que um importante pilar da prevenção da doença em humanos consiste na profilaxia pré-exposição dos grupos de risco, buscou descrever o perfil dos atendimentos para profilaxia antirrábica pré-exposição (PArPE) humana realizados pelas Secretarias Municipais de Saúde, conforme metodologia do PNPR do Ministério da Saúde (MS), no Estado, através de um estudo descritivo a partir de dados coletados no Sistema Nacional de Agravos de Notificação (SINAN Net) do MS. Foram coletados 238 morcegos e submetidos a diagnóstico rábico padrão e técnicas complementares. Daqueles em que se pode recuperar sangue, foi realizada sorologia. A prevalência de vírus rábico foi de 3,60%, confirmados por IFD, RT-PCR do cérebro e da glândula salivar. A prevalência de anticorpos através do teste rápido de inibição de foco da fluorescência (RFFIT) foi 23,27% enquanto que no microteste simplificado de inibição da fluorescência (SFIMT) foi de 51,5%. Por outro lado, foi demonstrado que há diversas inconsistências no uso da PArPE no RS, com uso de tratamento em muitas situações em que não haveria a indicação e, ao mesmo tempo, mantendo pessoas em situação de risco não protegidas. A implicação destes achados é discutida nos dois artigos. / The National Rabies Prophylaxis Program (PNPR) actions led to an important reduction of human cases and certain control of urban cycle in cats and dogs, in different regions of the country. However, rabies still is a serious Public Health issue in Brazil and in the world. The state of Rio Grande do Sul (RS) is an area where the urban rabies cycle is considered controlled for about 20 years, having no canine virus variants circulation and no human cases registered. However, the maintenance of chiropters wild cycles still is detected, including among urban areas. The research was divided in two sub-projects. The first one aimed studying the disease's aerial cycle in the city of Pelotas, RS, through gold standard diagnosis, molecular biology and serological techniques, and then establishing the rabies virus infection in bats. The second subproject, based on the understanding that the pre-exposure prophylaxis in risk groups is the cornerstone of human rabies prevention, sought describing the human anti-rabies pre-exposure prophylaxis intervention (PArPE) profile, performed in State public health secretariats, according the methodology presented in the Ministry of Health's National Human Rabies Prophylaxis Program, through a descriptive study using data collected by the Ministry of Health's National Notification of Diseases System (SINAN Net). To that end, 238 bats were collected and put through standard rabies diagnosis and complementary techniques. Serology was performed in those which blood was found. Rabies virus prevalence was 3.60%, confirmed through DFA test, and brain and salivary gland RT-PCR. Antibodies prevalence through Rapid fluorescent focus inhibition test (RFFIT) was 23.27%, and 51.5% through Simplified fluorescent inhibition microtest (SFIMT). On the other hand, it was shown that the PArPE application in RS is inconsistent, where the treatment has been used in many situations in which it wouldn't be indicated, and, at the same time, leaving people in risk situations unprotected. These results implications are discussed in both articles.

O Código Sanitário Municipal de Alimentos, Decreto Municipal n°25.544, de 14 de março de 1988, regulamentou a fiscalização sanitária de gêneros alimentícios no varejo até 26 de novembro de 2002, data em que entrou em vigor a Lei Estadual n° 10.083, de 23 de setembro de 1998, Código Sanitário do Estado de São Paulo, utilizado pelos serviços municipais de vigilância, em caráter temporário, até a promulgação do Código Sanitário do Município de São Paulo. Em 9 de janeiro de 2004, entrou em vigor a Lei Municipal n° 13.725, Código Sanitário do Município de São Paulo, regulamentando todos os serviços e produtos de interesse da saúde, inclusive a produção e distribuição de alimentos e água para consumo humano. A comparação entre os Códigos de 1988 e de 2004 permitiu a identificação das mudanças ocorridas na legislação e nos procedimentos administrativos da vigilância sanitária do varejo de alimentos no Município de São Paulo. Concluiu-se, também, que o Código Sanitário do Município de São Paulo é uma legislação completa e atualizada, com previsão legal de utilização de regulamentos técnicos modernos de forma combinada, especialmente os que tratam da produção e distribuição de alimentos, com ênfase nas Boas Práticas de Fabricação (BPFs). / Up to November 26th, 2002, the Municipal Food Standards, or else Municipal Decree NR 25544 as of March 14th, 1988, was the legislation applicable to food inspection in retail establishments. On that date, São Paulo state law number 10083, as of September 23, 1998 became effective and functioning as a temporary legislation applicable to municipal food inspection services, up to the enactment of the Sanitary Standards of the Municipality of São Paulo in the year 2004. Municipal Law Number 13725, or Sanitary Standards of the Municipality of São Paulo, was enacted on January 9th, 2004, applicable to all health-related services and products, including manufacturing and distribution of food and water for human consumption. Comparing the 1998 and 2004 Standards enabled an identification of the changes occurred at hygiene vigilance, food inspection regarding legislation and administrative procedures particulars, as applicable to retail establishments within the Municipality of São Paulo. It was possible to conclude that the sanitary, hygiene Standards of the Municipality of São Paulo comprise a complete legislation, continuously updated, including a legal provision for using a combination of modern technical regulations, especially those concerning food manufacturing and distribution, emphasizing Good Manufacturing Practices (GMP).

Nas últimas décadas encontramos nos documentos oficiais (PCNEM e PCN+) orientações quanto à necessidade da inserção da Física Moderna e Contemporânea (FMC) nas aulas de física no Ensino Médio. Nesse mesmo período, professores e pesquisadores já sinalizavam quanto a esses aspectos e percebe-se que existem pontos em comum em suas pesquisas quanto às dificuldades de implementação dessa inserção. Nessa perspectiva, alguns conteúdos já foram inseridos a partir de projetos de inovação curricular nas escolas públicas e por meio de cursos de formação continuada, atendendo às necessidades dos professores de física, mostrando, por exemplo, que é possível levar tais conteúdos para a sala de aula. Contudo, quando procuramos analisar as pesquisas referentes ao professor nesse contexto, percebe-se uma escassez de trabalhos que se ocupam da formação e da prática docente no contexto da inovação curricular e, mais especificamente, da inserção da FMC. Dessa forma, este trabalho procura analisar a formação e a prática do professor nesse contexto, apresentando uma articulação possível entre a Teoria da Transposição Didática (TTD) e a Teoria Antropológica do Didático (TAD), ambas de Chevallard, na identificação das praxeologias adotadas pelo professor durante o processo de didatização dos saberes, na perspectiva de que ele desempenha um papel central e, ao mesmo tempo, sensível no momento de transformar o saber até que este chegue à sala de aula. Para isso, foi realizada uma pesquisa qualitativa, centrada em um estudo de caso, no qual é analisada a prática docente de um professor de física da rede pública que participou de um curso de formação continuada no contexto da inovação curricular, e que, posteriormente, trabalhou com uma sequência didática sobre a temática da dualidade onda-partícula no Ensino Médio. Assim, busca-se identificar as praxeologias transpostas do curso de formação continuada para a sala de aula, bem como o exercício da vigilância epistemológica ao longo desse processo. / In the official documents (PCNEM and PCN+) of recent decades an orientation on the need to insert Modern and Contemporary Physics (MCP) in high school physics classes was published. In the same period, teachers and researchers already signaled on these matters and it is noticed that there are common difficulties to implement this insertion, as related in their research about this subject. From this perspective, some contents on curriculum innovation projects in public schools have been suggested giving pedagogical updating courses focusing on the physics teachers needs, showing, for example, that it is possible to take such contents in a the classroom. However, when we analyzed the research on the teacher in this context, there is a perceived lack of studies dealing with training and teaching practice in the context of curriculum innovation and, more specifically, the insertion of the MCP. Thus, this paper analyzes the formation and practice of teacher in this context, indicating a possible link between the Didactic Transposition Theory (DTT) and the Anthropological Theory of the Didactic (ATD), both of Chevallard, in the identification of the praxeologies adopted by the teacher during a didactization process of knowledge, from the standpoint that it plays a central role. At the same time, it is analyzed how the teacher shows to be sensitive until the knowledge turns to reach the classroom. For this, a qualitative research was conducted, focusing on a case study, where the teaching practice of a physics professor at the public school who participated in a continual education course in the context of curriculum innovation, and subsequently worked with a teaching sequence on the topic of wave-particle duality in high school. Thus, we seek to identify the transposed praxeologies the continuing education course for the classroom, and how is the exercise of epistemological vigilance throughout this process.