No abstract available. / Dissertation (MA)--University of Pretoria, 1976. / gm2014 / Anthropology and Archaeology / Unrestricted

The Dutch born organist, conductor, music pedagogue, church musician and composer, Willem Mathlener left a rich inheritance in the field of organ music in South Africa. He was born in 1909 in Delft in the Netherlands and distinguished himself as an organist and conductor in the thirties and forties of the previous century. He answered the calling of the Nederduitsch Reformed Church in South Africa to improve the standard of church music by immigrating to South Africa in 1948 at the age of 39. He settled in Vereeniging as a music teacher and organist from where he started to introduce his ideas about church music to the Nederduitsch Reformed Church and others. This led to the establishment of the Council for Church Music in 1951. Three years later the Church Music School in Krugersdorp was founded. This institution developed to such an extent that the Conservatoire for Music, Pretoria was established in 1960, the institution that Mathlener was mostly associated with. He implemented his beliefs about musical training which was the result of his own training at a European Conservatoire at both these institutions. As the secretary of the Council for Church Music he had a profound influence on the development and promotion of church music in South Africa. He assisted in the compilation of the Psalm and Hymn book of 1978 by supplying a large number of harmonisations for Hymns in this volume. As an organ advisor he designed about 200 organs. Mathlener’s talent as a composer developed naturally through his capacity as church musician and pedagogue. He composed organ music that can be used supplementary to the organist’s task as accompanist. His piano music fills the need for short study pieces for piano tuition. Since the majority of Mathlener’s compositions do not exceed 30 bars he can be considered to be a miniaturist. His choral arrangements show for the most part a diatonic tonality and a contrapuntal texture which blends in with the style of music for liturgical use. A Psalm or Hymn melody forms mainly the basis for his organ music. Mathlener’s large compositional output which comprises 223 choral harmonisations, 175 works for organ, 53 works for piano and 12 vocal works created the need for a system to arrange his compositions in an orderly fashion. Some of his compositions were published in volumes and others are single unpublished works. The catalogue attempts to arrange Mathlener’s compositions in a logical way thus forming a comprehensive picture of the oeuvre of this composer as well as providing a useful reference tool for organists and other interested people. / Dissertation (MA)--University of Pretoria, 2015. / tm2015 / Music / MA / Unrestricted

AFRIKAANS: Die Suid-Afrikaanse Akademie vir Wetenskap en Kuns vier vanjaar sy eeufees. Hierdie instansie is die kurator van die Hertzogprys, ’n gesogte letterkundeprys en die oudste en bekendste prestigetoekenning wat deur hierdie instansie gemaak word. Die terrein wat deur hierdie proefskrif gedek word, is die Akademie se houding teenoor en bevordering van Afrikaanse drama, met ’n geslypter fokus op die Hertzogprystoekennings vanaf 1915 tot net voor 1972. Etlike gegewens met betrekking tot die prys soos aangebied in reeds gepubliseerde werk, is verwarrend of nie feitelik korrek nie. Ten einde klarigheid daaroor te kry, is ’n grondige studie gemaak van die toekenningsprosedures en die invloed daarvan op die dramabekronings tot voor 1972. Dit was veral verhelderend met betrekking tot die dramaturg Uys Krige. Aanvanklik het die drie literêre kategorieë prosa, poësie en drama gelyktydig in aanmerking gekom vir die prys. Vanaf 1928 roteer dit en kom Afrikaanse dramas elke derde jaar aan die beurt. In vergelyking met die literêre kategorieë prosa en poësie, is daar relatief min dramabekronings gemaak – veral aan die beginjare van die prys. Deur noukeurige studie is gepoog om die gebrek aan dramatoekennings in perspektief te stel. Klem word gelê op die rol wat prosedures gespeel het, byvoorbeeld minder goeie prosedures wat veroorsaak het dat die verkeerde of geen toekennings gemaak is nie en sodoende bygedra het tot ’n skewe beeld wat bestaan oor Hertzogprystoekennings vir Drama. Sekere toekennings (of gebrek daaraan) kan direk gekoppel word aan foutiewe uitsprake van administratiewe amptenare, onbevredigende prosedures of aan die invloed van persone wat seggenskap oor die prys gehad het. Bepalende bakens en beslissings word aangetoon. Die sestigerjare was in die geskiedenis van die land en van die Akademie vol beroeringe. Met betrekking tot die Akademie se beleid oor die handhawing en bevordering van die Afrikaanse kultuur, het Akademielede van mekaar verskil oor die vertolking en uitlewing daarvan. Dit het gelei tot uiteenlopende menings oor die rigting wat die Akademie moes inslaan, maar ook oor sekere literêre werke. Verskillende menings het geheers oor wie die finale seggenskap oor die Hertzogprys moes hê: die Akademieraad as kurator van die prys volgens die skenkingsakte, of die Letterkundige Kommissie wat die kundiges op letterkundegebied was. Hierdie meningsverskille is op die spits gedryf in 1966 – die jaar waarin Uys Krige vir ’n dramatoekenning aanbeveel is. Die Akademieraadsbesluit om nie daardie jaar ’n prys toe te ken nie, het hewige kritiek ontlok – selfs van Kommissielede, en sou nog vir jare daarna ’n rimpeleffek hê. Die eerste staande Letterkundige Kommissie is aangewys vir die periode April 1968 tot April 1971 en die eerste toekenning waaroor hulle moes besluit, was die Dramatoekenning van 1969. In teenstelling met die stormagtige sestigerjare, het dramabekronings in die jare daarna verloop sonder onmin tussen die Akademieraad, die Fakulteitsraad en die Letterkundige Kommissie. Die jare waartydens ’n Hertzogprys vir Drama toegeken kon word vanaf 1972 tot 2009, word slegs kortliks en skematies gedek om die bespreking af te rond met betrekking tot dié dramaturge wat reeds voor 1972 gedebuteer het, maar eers daarna met die prys bekroon is. ENGLISH: The year 2009 marks the centenary celebrations of the Suid-Afrikaanse Akademie vir Wetenskap en Kuns. This institution is the curator of the Hertzog Prize, a sought-after literary prize and the oldest and most prestigious award made by this institution. This dissertation focuses on the Academy’s attitude towards and advancement of Afrikaans drama, with the focus on the Hertzog Prize awards from 1915 until 1971. Certain information relating to the prize as recorded in previously published works on the subject, are confusing and factually incorrect. In an effort to clarify these, an in depth study was undertaken of the award procedures and their influence on the awards for drama up to 1972. It was especially enlightening with regard to the dramatist Uys Krige. Initially the three literary categories prose, poetry and drama were considered simultaneously, but as from 1928 they rotate and Afrikaans dramas are considered every third year. In comparison with the literary categories prose and poetry, there is a paucity of drama awards – especially during the early years of the prize. An effort was made to place the paucity in perspective. Emphasis is placed on procedures with specific reference to those less than perfect ones which lead to incorrect, or the lack of, awards, resulting in a warped image of drama awards. Certain awards or lack thereof, can be attributed to incorrect statements by administrators, unsatisfactory procedures or the influence of people with authority. Defining beacons and decisions are indicated. In the nineteen sixties the country and the Academy experienced years of turbulence. With regards to the Academy’s policy on the protection and advancement of Afrikaans culture, members of the Academy differed on the interpretation and implementation thereof. This lead to differing views on the Academy’s course and on certain literary works. There were different views on who should have the final say on the Hertzog Prize: the Board as curator of the prize according to the deed of gift, or the Commission for Literature as literary experts. These differences lead to a boiling point in 1966 when Uys Krige was nominated for the prize. The Board’s decision not to award the prize lead to severe criticism – even from members of the Committee, and had a ripple effect for years thereafter. The first standing Commission for Literature was appointed for the period April 1968 to April 1971 and the first award they had to adjudicate was the Drama award for 1969. As opposed to the stormy sixties, the awards for drama in the following years were made without discord between the board of the Academy, the Faculty and the Commission for Literature. The years during which the Drama Prize could be awarded during the period 1972 to 2009 are dealt with briefly and schematically in order to conclude the discussion with reference to those dramatists who made their drama debut before 1972, but were only awarded the Hertzog Prize after 1972. / Thesis (DLitt)--University of Pretoria, 2009. / Afrikaans / unrestricted

No description available.

la ricerca si propone lo studio della figura di Lucio Quinzio Cincinnato, paradigma di vir Romanus della prima età repubblicana, e della sua gens di appartenenza, la gens Quinzia, lungo tutto l'arco della sua esistenza. Scopo del lavoro è quello di decodificare come è stata costruita nel tempo, da parte della cultura romana, la figura esemplare di Cincinnato, evidenziando gli eventuali aspetti storici della sua vicenda e le possibili stratificazioni storiografiche e “ideologiche” successive che ne hanno fatto un personaggio paradigmatico della storia di Roma. / The research aims to study the figure of Lucius Quinctius Cincinnatus, a paradigmatic vir Romanus of the early roman Republic, and his belonging clan, the gens Quinctia, throughout its existence. Aim of the work is to decode how it was built over time by the roman culture, the exemplary figure of Cincinnatus, highlighting any historical aspects of his story and the subsequent historiographical and "ideological" layers that have made it a paradigmatic character of the roman history.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Orf virus (ORFV) belongs to the family Poxviridae, subfamily Chordopoxvirinae and genus Parapoxvirus and is the agent of contagious ecthyma, a mucocutaneous disease that affects mainly young sheep and goats and, occasionally, may affect people. The clinical lesions progress through stages of hyperemia, papules, vesicles, pustules, ulcers and proliferative and scabby lesions, located mainly on the labial commissure, lips and nostrils. Variable clinical lesions with different degrees of severity often occur in sheep and goats, and may be associated with host and/or viral genetics. The present study aimed to investigate the phenotype in vivo and to characterize virulence genes of four ORFV isolates recovered from contagious ecthyma outbreaks in Rio Grande do Sul State, Brazil. Twenty sheep, aged 6 and 8 months, were divided into five groups of four animals each and inoculated in the labial commissure with homogenates of scabs (viral titers 105.6TCID50/ml) obtained from different outbreaks: SV269/11, SV252/11, SV581/11 and SV820/10-Canguçu. The animals were evaluated for 30 days in clinical and virological aspects by clinical inspection and swab collection for virus isolation. A clinical score was established for each animal and group. All ORFV inoculated animals developed classical ecthyma contagious lesions, characterized by hyperemia, papules, macules, vesicles, pustules and scabs in varied degrees and duration. SV269/10 and SV820/10-Canguçu isolates induced more severe lesions resulting in higher clinical scores and longer duration of lesions. The animals inoculated with SV581/11 developed milder lesions and clinical scores significantly lower than other groups, but they shed virus for a longer period of time. For genetic analyses, PCR amplification and nucleotide sequencing of three virulence genes (VEGF, VIR and IL-10v) were performed. Deletion and mutations on VEGF and IL-10v amino acid sequence of SV581/11 and SV252/11 isolates were identified. The degree of amino acid identity among ORFV sequences was variable, and the lowest homology was found in the VEGF gene of SV581/11 when compared with the standard strains and other viruses. Thus, the present results showed that SV581/11 and SV252/11 isolates, particularly the former, are less virulent in sheep than SV269/11 and SV820/10-Canguçu. Possibly, the variable phenotypic observed in vivo is due to genetic alterations detected in the analyzed virulence genes. / O vírus da orf (ORFV) pertence à família Poxviridae, subfamília Chordopoxvirinae gênero Parapoxvirus e é o agente etiológico do ectima contagioso, uma doença mucocutânea que afeta principalmente ovinos e caprinos jovens e pode, ocasionalmente, afetar pessoas. Clinicamente, a enfermidade evolui com a formação de áreas hiperêmicas, vesículas, pústulas, úlceras e lesões proliferativas e crostosas sobre a pele dos lábios, comissura labial e narinas. Apresentações clínicas variáveis, com diferentes graus de severidade, ocorrem frequentemente e podem estar associadas a características do hospedeiro e, principalmente, a características genéticas do agente. O presente trabalho teve como objetivo investigar o fenótipo in vivo e caracterizar genes de virulência de quatro amostras de ORFV oriundas de surtos no Estado do Rio Grande do Sul, Brasil. Para isso, foram utilizados vinte ovinos, com idade entre 6 e 8 meses, divididos em cinco grupos de quatro animais cada. Os ovinos foram inoculados na comissura labial com homogeneizados de crostas (títulos virais 105,6 DICC50/ml) obtidas dos surtos (amostras SV269/11, SV252/11, SV581/11 e SV820/10-Canguçu). Os animais foram avaliados durante 30 dias com relação aos aspectos clínicos e virológicos, por inspeção clínica e coleta de suabes das lesões para detecção da excreção viral. As manifestações clínicas foram convertidas em um escore clínico, para cada animal e para os grupos. Os animais inoculados com os as quatro amostras desenvolveram lesões típicas de ectima contagioso, caracterizadas por hiperemia, pápulas, máculas, vesículas e pústulas, e formação de crostas em diferentes graus de intensidade e duração. As amostras SV269/10 e SV820/10-Canguçu induziram lesões mais graves, escores clínicos maiores e maior tempo de duração das lesões. Os animais inoculados com a amostra SV581/11 desenvolveram lesões e escores clínicos significativamente inferiores aos demais grupos, mas excretaram o vírus por período mais longo. Para a caracterização genética, foi realizada a amplificação por PCR e sequenciamento de nucleotídeos de três genes de virulência (VEGF, VIR e IL-10v). Foram identificadas deleções e mutações nas sequências dos genes VEGF e IL-10v das amostras SV581/11 e SV252/11. O grau de identidade de aminoácidos entre as amostras foi variável, sendo que a menor homologia foi encontrada no gene VEGF da amostra SV581/11, quando comparado com os demais vírus e a cepa padrão. Assim, os resultados obtidos demonstram que as amostras SV581/11 e SV252/11, em especial a primeira, foram menos virulentas em ovinos do que as amostras SV269/11 e SV820/10-Canguçu. Possivelmente essa diferença fenotípica observada in vivo seja resultado das alterações genéticas detectadas nos genes de virulência.

Caffeine is frequently used in cosmetics due to its well-characterised skin permeation properties and is widely incorporated in cosmetic-related products intended for skin (Samah & Heard, 2013:631). Despite its polar characteristics (Dias et al., 1999:41), caffeine is an important biologically and cosmetically active compound (Herman & Herman, 2012:13). This active pharmaceutical ingredient (API) has a broad range of advantages in the world of cosmetics, including the improvement of microcirculation in the capillaries (Lupi et al., 2007:107), showing anti-cellulite activity in the fatty tissue (Velasco et al., 2008:24), anti-oxidation activity in sunscreens & anti-ageing products (Koo et al., 2007:964) and the stimulation of hair growth (Fisher et al., 2007:27). Caffeine has also shown significant decreases in UV-induced skin tumour multiplicity (Lu et al., 2001:5003, 5008) and has been proven to prevent photo-damaged skin, which includes the formation of wrinkles and histological alterations (Mitani et al., 2007:86). It is therefore clear that the challenge for the dermal delivery of the hydrophilic caffeine is for it to be retained in the specific skin layers (dermal delivery) where it can exert its action, rather than to permeate through the skin and into the hydrophilic systemic circulation (transdermal delivery) (Wiechers et al., 2008:10). In this study the calculated skin delivery gap (SDG) values, and the transdermal and dermal delivery of caffeine from three different semi-solid topical formulations were compared. The SDG theory was developed to evaluate the effectiveness of dermal delivery of API from topical formulations and is known as the ratio between the concentration required to achieve minimum effect relative to the concentration obtained at the target site (JW Solutions, 2011). During this study the principle of the SDG was investigated by using the formulating strategy, Formulating for Efficacy (FFE™), which aims to optimise skin delivery of APIs from different formulations. The SDG was therefore implemented and in vitro transdermal studies were utilised to ultimately prove or disprove the hypothesis of SDG on the prediction of the topical delivery of caffeine. The human skin consists of two distinctive layers namely the epidermis (including the stratum corneum (SC) and viable dermis) and the dermis (Menon, 2002:S3). The main barrier to dermal and transdermal permeation is the outermost layer of the skin, the SC (Fang et al., 2007:343). The difference between the target site for dermal and transdermal delivery of APIs is crucial to be mentioned. Dermal delivery includes the delivery of an API to the skin surface, SC, viable epidermis or dermis, whereas transdermal delivery requires the API to permeate all the way through the various skin layers and into the systemic circulation (Wiechers, 2000:42). Since this study involves the optimisation of the topical delivery of caffeine, the physicochemical properties of this API as well as those of the skin should be considered. As mentioned before, caffeine is a rather polar molecule (Dias et al., 1999:41), whereas the SC (lipophilic) provides the rate-limiting barrier to the percutaneous absorption of polar (hydrophilic) molecules, such as caffeine (Barry, 1983:105). Caffeine was incorporated into three different formulations: a gel and two creams (differing only in the ratio of the primary and secondary emollient). The three topical formulations each had different polarities, where the Gel represented the hydrophilic formulation (more polar than the skin), whereas the first cream, Cream 1 (containing 5% DMI and 9% glycerine), served as the intermediate formulation (similar polarity as the SC), and the second cream, Cream 2 (10% DMI and 4% glycerine), was the formulation less polar (therefore more lipophilic) than the SC. Franz cell type transdermal diffusion studies were performed on the three semi-solid formulations (Gel, Cream 1 and Cream 2). The diffusion studies were conducted over a period of 12 h, followed by the tape stripping of the skin directly after each diffusion study. Caucasian female abdominal skin was obtained with consent from willing donors. Ethical approval for the acquisition and use of the donated skin was granted under reference number NWU-00114-11-A5. The formulations each contained 1% of caffeine as API. The skin used for the diffusion studies was prepared with the use of a Zimmer Dermatome®. The receptor phase of each Franz cell was withdrawn at predetermined time intervals and subsequently analysed with high performance liquid chromatography (HPLC) in order to determine the concentration of caffeine that permeated through the skin. Stratum corneum-epidermis (SCE) and epidermis-dermis (ED) samples were prepared and left overnight at a temperature of 4 °C, and they were analysed the following day with the use of HPLC in order to determine the concentration of caffeine that had accumulated in the particular skin layers. The SDG value for each caffeine formulation was calculated and it was compared to the flux and tape stripping results obtained from the diffusion studies. To ultimately prove or disprove the SDG theory, the skin diffusion studies and tape stripping results were used to determine whether any difference occurred in the absorption or penetration of the API from the different formulations into the skin. The formulation with the intermediate polarity (Cream 1) produced the highest transdermal flux of caffeine due to the hydrophilic and lipophilic nature of caffeine and the formulation, respectively. Cream 1 is sufficiently lipophilic to transport caffeine into the SC and at the same time sufficiently hydrophilic (more polar than Cream 2) to cause a greater driving force of caffeine through to the more hydrophilic epidermis, dermis and systemic circulation. The results from the tape stripping yielded that Cream 2 (the more lipophilic formulation) produced the highest concentration of caffeine into the SCE due to the hydrophilic and lipophilic nature of caffeine and the formulation, respectively. The difference in polarity between the formulation and the API in Cream 2 was the greatest compared to the other formulations, which significantly increased the driving force of caffeine to partition into the SC (Wiechers et al., 2004:177). The hydrophilic gel showed the highest concentration of caffeine in the ED layer of the skin due to the hydrophilic compounds formulated in the Gel, which showed greater ability to partition into the aqueous dermis and viable epidermis (Imai et al., 2013:372). Cream 2 had the lowest calculated SDG value compared to that of the Gel and Cream 1. The smaller the delivery gap, the greater the delivery of the API should be into the skin (Wiechers, 2010). Considering this, it was expected that Cream 2 would deliver greater amounts of caffeine into the skin than the more hydrophilic formulations. Cream 2, which showed the lowest calculated SDG value delivered the highest amount of caffeine into the SCE during the diffusion studies. The calculated SDG values therefore are consistent with the concentration of caffeine in the SCE (the lowest SDG value produced the highest concentration of API in the SCE). However, no correlations were found between the calculated SDG values and ED delivery or the flux of caffeine. The final conclusion for this study is that the SDG theory proved to be effective and trustworthy regarding the delivery of caffeine into the SC. / MSc (Pharmaceutics), North-West University, Potchefstroom Campus, 2014

Caffeine is frequently used in cosmetics due to its well-characterised skin permeation properties and is widely incorporated in cosmetic-related products intended for skin (Samah & Heard, 2013:631). Despite its polar characteristics (Dias et al., 1999:41), caffeine is an important biologically and cosmetically active compound (Herman & Herman, 2012:13). This active pharmaceutical ingredient (API) has a broad range of advantages in the world of cosmetics, including the improvement of microcirculation in the capillaries (Lupi et al., 2007:107), showing anti-cellulite activity in the fatty tissue (Velasco et al., 2008:24), anti-oxidation activity in sunscreens & anti-ageing products (Koo et al., 2007:964) and the stimulation of hair growth (Fisher et al., 2007:27). Caffeine has also shown significant decreases in UV-induced skin tumour multiplicity (Lu et al., 2001:5003, 5008) and has been proven to prevent photo-damaged skin, which includes the formation of wrinkles and histological alterations (Mitani et al., 2007:86). It is therefore clear that the challenge for the dermal delivery of the hydrophilic caffeine is for it to be retained in the specific skin layers (dermal delivery) where it can exert its action, rather than to permeate through the skin and into the hydrophilic systemic circulation (transdermal delivery) (Wiechers et al., 2008:10). In this study the calculated skin delivery gap (SDG) values, and the transdermal and dermal delivery of caffeine from three different semi-solid topical formulations were compared. The SDG theory was developed to evaluate the effectiveness of dermal delivery of API from topical formulations and is known as the ratio between the concentration required to achieve minimum effect relative to the concentration obtained at the target site (JW Solutions, 2011). During this study the principle of the SDG was investigated by using the formulating strategy, Formulating for Efficacy (FFE™), which aims to optimise skin delivery of APIs from different formulations. The SDG was therefore implemented and in vitro transdermal studies were utilised to ultimately prove or disprove the hypothesis of SDG on the prediction of the topical delivery of caffeine. The human skin consists of two distinctive layers namely the epidermis (including the stratum corneum (SC) and viable dermis) and the dermis (Menon, 2002:S3). The main barrier to dermal and transdermal permeation is the outermost layer of the skin, the SC (Fang et al., 2007:343). The difference between the target site for dermal and transdermal delivery of APIs is crucial to be mentioned. Dermal delivery includes the delivery of an API to the skin surface, SC, viable epidermis or dermis, whereas transdermal delivery requires the API to permeate all the way through the various skin layers and into the systemic circulation (Wiechers, 2000:42). Since this study involves the optimisation of the topical delivery of caffeine, the physicochemical properties of this API as well as those of the skin should be considered. As mentioned before, caffeine is a rather polar molecule (Dias et al., 1999:41), whereas the SC (lipophilic) provides the rate-limiting barrier to the percutaneous absorption of polar (hydrophilic) molecules, such as caffeine (Barry, 1983:105). Caffeine was incorporated into three different formulations: a gel and two creams (differing only in the ratio of the primary and secondary emollient). The three topical formulations each had different polarities, where the Gel represented the hydrophilic formulation (more polar than the skin), whereas the first cream, Cream 1 (containing 5% DMI and 9% glycerine), served as the intermediate formulation (similar polarity as the SC), and the second cream, Cream 2 (10% DMI and 4% glycerine), was the formulation less polar (therefore more lipophilic) than the SC. Franz cell type transdermal diffusion studies were performed on the three semi-solid formulations (Gel, Cream 1 and Cream 2). The diffusion studies were conducted over a period of 12 h, followed by the tape stripping of the skin directly after each diffusion study. Caucasian female abdominal skin was obtained with consent from willing donors. Ethical approval for the acquisition and use of the donated skin was granted under reference number NWU-00114-11-A5. The formulations each contained 1% of caffeine as API. The skin used for the diffusion studies was prepared with the use of a Zimmer Dermatome®. The receptor phase of each Franz cell was withdrawn at predetermined time intervals and subsequently analysed with high performance liquid chromatography (HPLC) in order to determine the concentration of caffeine that permeated through the skin. Stratum corneum-epidermis (SCE) and epidermis-dermis (ED) samples were prepared and left overnight at a temperature of 4 °C, and they were analysed the following day with the use of HPLC in order to determine the concentration of caffeine that had accumulated in the particular skin layers. The SDG value for each caffeine formulation was calculated and it was compared to the flux and tape stripping results obtained from the diffusion studies. To ultimately prove or disprove the SDG theory, the skin diffusion studies and tape stripping results were used to determine whether any difference occurred in the absorption or penetration of the API from the different formulations into the skin. The formulation with the intermediate polarity (Cream 1) produced the highest transdermal flux of caffeine due to the hydrophilic and lipophilic nature of caffeine and the formulation, respectively. Cream 1 is sufficiently lipophilic to transport caffeine into the SC and at the same time sufficiently hydrophilic (more polar than Cream 2) to cause a greater driving force of caffeine through to the more hydrophilic epidermis, dermis and systemic circulation. The results from the tape stripping yielded that Cream 2 (the more lipophilic formulation) produced the highest concentration of caffeine into the SCE due to the hydrophilic and lipophilic nature of caffeine and the formulation, respectively. The difference in polarity between the formulation and the API in Cream 2 was the greatest compared to the other formulations, which significantly increased the driving force of caffeine to partition into the SC (Wiechers et al., 2004:177). The hydrophilic gel showed the highest concentration of caffeine in the ED layer of the skin due to the hydrophilic compounds formulated in the Gel, which showed greater ability to partition into the aqueous dermis and viable epidermis (Imai et al., 2013:372). Cream 2 had the lowest calculated SDG value compared to that of the Gel and Cream 1. The smaller the delivery gap, the greater the delivery of the API should be into the skin (Wiechers, 2010). Considering this, it was expected that Cream 2 would deliver greater amounts of caffeine into the skin than the more hydrophilic formulations. Cream 2, which showed the lowest calculated SDG value delivered the highest amount of caffeine into the SCE during the diffusion studies. The calculated SDG values therefore are consistent with the concentration of caffeine in the SCE (the lowest SDG value produced the highest concentration of API in the SCE). However, no correlations were found between the calculated SDG values and ED delivery or the flux of caffeine. The final conclusion for this study is that the SDG theory proved to be effective and trustworthy regarding the delivery of caffeine into the SC. / MSc (Pharmaceutics), North-West University, Potchefstroom Campus, 2014

Thesis (MA (Ancient Studies)--University of Stellenbosch, 2008. / The term vir bonus as a comprehensive concept is nowhere precisely defined, yet the Romans clearly understood its meaning. To give substance to it, the role that the good Roman or vir bonus was expected to play in the Roman Republic, was examined. By his extensive descriptions of the evils of the Empire, Tacitus confirms this concept by emphasizing the absence of these exemplary qualities. The development of Rome from city state to Monarchy to Republic is steeped in legend. The foundation of the Roman constitution was believed to have been laid during that period, and adjusted to prevent the recurrence of a monarchy. This system of government was closely structured and demanded a high moral standard from its participants. While Roman territory was limited, this constitution functioned well. However, when after the Punic Wars Rome became master of almost the whole area surrounding the Mediterranean Sea, it was impracticable. A long and often bloody strife followed between the advocates of change and those who would not accept it. Augustus won out and established an Empire, calling it by the euphemistic term of Principate. His successors automatically acceded to their powers as emperor. During the Empire the political structures of the Republic were disempowered and the moral fibre of the ruling classes perverted. It is this process that Tacitus examines critically. He does so by describing how different people reacted under different circumstances. Some behaviour he roundly condemns, but often he makes us realise that the participants did not have much leeway, and that this consequently affected their behaviour .

AFRIKAANS : Hierdie studie is onderneem om te bepaal wat die persepsies van boere in die Letaba Distrik is oor die invloed van die instelling van die minimum loon vir landbou op hulle boerderybesighede. Die navorser wou bepaal of die boere hulle werknemers se werkskontrakte aangepas het of die loonpakket geherstruktureer het om vir die invloed op hulle boerderybesigheid te kompenseer. Die navorser wou ook bepaal of die indiensneming van plaaswerkers beïnvloed is. Laastens wou die navorser bepaal wat die invloed van die instelling van die minimum loon op die organisasiegedrag van plaaswerkers was. Om antwoorde op bogenoemde vraagstukke te verkry, het die navorser ‘n vraelys spesifiek vir die doeleindes van hierdie studie ontwerp. Die vraelys is deur al die sitrus boere in die Letaba distrik voltooi. Na bestudering van die inligting wat uit die data van die vraelyste verkry is, het die navorser tot die gevolgtrekking gekom dat boere permanente werknemers met tydelike werknemers vervang het en die loonpakket aangepas het deur die kontantloon te verhoog, maar ook die aftrekkings vir dienste en goedere wat voorheen kosteloos verskaf is. Indiensneming van plaaswerkers is baie negatief beïnvloed, met ongeveer 1270 permanente poste wat afgeskaf is na die instelling van die minimum loon. Wat die invloed op organisasiegedrag betref, het die minimum loon geen invloed na ‘n klein negatiewe invloed op afwesigheid en personeelomset getoon. Ten opsigte van produktiwiteit was werkgewers van mening dat, waar produktiwiteit verhoog het, dit as gevolg van beter bestuurspraktyke was. Werkgewers glo eerder dat die instelling van die minimum loon hulle werknemers se produktiwiteit laat daal het. Die implikasies van die resultate van hierdie studie is verreikend wanneer in ag geneem word dat bykans 1270 permanente poste op slegs 38 plase afgeskaf is. Dit impliseer dat die aantal poste wat in die landbou as geheel afgeskaf is, baie groot kan wees. Die persepsies van die boere oor die instelling van die minimum loon was dat dit ‘n bedreiging vir die volhoubaarheid van hulle boerderybesighede inhou en dat dit hulle verplig om stappe te neem om daarvoor te kompenseer, stappe wat nie noodwendig tot voordeel van werknemers strek nie. ENGLISH : This study was undertaken to ascertain what the perceptions of farmers in the Letaba district aren about the impact of the introduction of the minimum wage for agriculture on their farming businesses. The researcher wanted to ascertain whether the farmers adapted their workers’ contracts or restructured their wage package to compensate for the impact on the farming businesses. The researcher also wanted to ascertain whether the employment of farm workers were influenced. Lastly, the researcher wanted to ascertain what the influence of the introduction of the minimum wage was on the organisational behaviour of farm workers. To get answers on the above mentioned issues, the researcher designed a questionnaire specifically for this study. The questionnaire was completed by all the citrus farmers in the Letaba district. After studying the information derived from the data of the questionnaires, the researcher came to the conclusion that farmers substituted permanent workers with temporary workers and adapted the wage package by raising the cash wage but also the deductions of goods and services that were previously provided free of charge. Employment of farm workers were influenced very negatively with about 1270 permanent jobs that were scrapped after the introduction of the minimum wage. Regarding the impact on organisational behaviour, the minimum wage showed a small negative to no influence on absenteeism and worker turnover. Regarding productivity, employers were of the opinion the, where productivity was raised, it was due to improved management practises. Employers believe that the introduction of the minimum wage caused their workers’ productivity to decrease. The implications of the results of this study are far reaching when it is taken into account that roundabout 1270 permanent jobs were lost on only 38 farms. This implies that the amount of jobs lost in agriculture as a whole, could be great. The perceptions of farmers about the introduction of the minimum wage are that it is a threat to the sustainability of their farming businesses and that it obliges them to take steps to compensate for the impact, steps that aren’t always advantageous for the workers. Copyright 2008, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. Please cite as follows: Minnaar, ME 2008, Persepsies oor die uitwerking van minimum lone op die sitrusbedryf (Afrikaans), MCom dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://upetd.up.ac.za/thesis/available/etd-02132012-100400 / > C12/4/72/gm / Dissertation (MCom)--University of Pretoria, 2012. / Human Resource Management / unrestricted