The objective of this thesis was to determine the association between exposure to parental BD during childhood and risk of mood disorder. Offspring of one parent with BD completed annual clinical assessments as part of a 16-year prospective cohort study. Clinical data in the parents from Ottawa and Halifax were mapped onto the first decade of their offspring’s life to estimate the timing, duration and severity of exposure to their illness. The duration of parental BD was associated with a 2 to 2.5 fold increased risk of any psychopathology (HR: 1.9, 95%CI: 1.0-4.0), and unipolar depression (HR: 2.6, 95%CI: 0.9-7.5), and a 7 fold increased risk of substance use disorders (HR: 7.1, 95%CI: 1.8-37.0). A longer duration of exposure to parental BD may be an important indicator of mood and non-mood psychopathology risk in offspring. This has implications for early intervention and preventive efforts in high-risk youth.

Sofrer bullying na infância e na adolescência se configura como fator de risco para a instalação e manutenção de problemas de comportamento e de transtornos psiquiátricos. A adversidade familiar, por sua vez, contribui para o envolvimento em situações de bullying. Os objetivos do presente estudo foram: (1) avaliar e comparar os escores de problemas de comportamento em dois grupos (vítimas e não vítimas de bullying), obtidos por meio do autorrelato e do relato dos professores e (2) verificar correlações entre os escores de adversidade familiar e de problemas de comportamento nos dois grupos. Participaram 154 adolescentes, dos quais 31 (20,1%) foram identificados como vítimas de bullying, por meio da Escala de Violência Escolar (EVE) e da versão traduzida do Peer Assessment. Para avaliar os problemas de comportamento foram utilizadas as versões brasileiras do Youth Self Report/11-18 (YSR) e do Teacher Report Form (TRF). O índice de adversidade familiar (IAF) avaliou o nível de adversidade familiar entre as famílias. Mais adolescentes vítimas de bullying foram avaliados com problemas de comportamento internalizantes, externalizantes e totais em nível clínico, quando comparados ao grupo de não vítimas. As maiores diferenças entre grupos foram verificadas na subescala de Depressão e Ansiedade, a partir do relato dos adolescentes, e na escala de Comportamento Agressivo, de acordo com os professores. Os alunos alvos de bullying relataram mais problemas de comportamento internalizantes (F=13,3 e p=0,001) e menos problemas de comportamento externalizantes (F=6,63 e p=0,013), quando comparados ao relato de seus professores. A presença de discórdia conjugal foi mais frequente em famílias de alunos vítimas de bullying, atingindo diferença estatisticamente significativa entre os grupos ( 2 =4,2 e p=0,04). Houve correlação positiva e ligeira entre os escores de problemas de comportamento, relatados pelos alunos, e os escores de adversidade familiar (=0,288 e p=0,001). Embora os escores de problemas de comportamento, sobretudo internalizantes, relatados por vítimas de bullying tenham sido significativamente superiores aos relatados por não vítimas, e tenham atingido níveis clínicos, os professores parecem não estarem sensíveis a estes indicadores. Identificar problemas de comportamento e características familiares adversas associadas à vitimização, assim como avaliar a percepção dos próprios envolvidos e de seus professores, contribui para o desenvolvimento de medidas preventivas de bullying em escolas brasileiras / Being bullied in childhood and adolescence is configured as a risk factor for the installation and maintenance of behavioral problems and psychiatric disorders. Family adversity, in turn, contributes to involvement in bullying situations. The aims of the study were: (1) to evaluate and compare the scores of behavior problems in two groups (victims and non-victims of bullying), obtained by self-report and by teachers report, and (2) examine correlations between the scores of family adversity and behavior problems of the two groups. Participated 154 adolescents, of whom, 31 (20.1%) were identified as victims of bullying, through the School Violence Scale (EVE) and through the translated version of the Peer Assessment. To assess the behavioral problems, the Brazilian versions of the Youth Self Report/11-18 (YSR) and the Teacher Report Form (TRF) were used. The family adversity index (LAI), from Rutter, assessed the level of family adversity among the families. Most adolescent victims of bullying were assessed with internalizing problems, externalizing, and total behavior at a clinical level, when compared with non-victims. The biggest differences between groups were found in the subscale of Depression and Anxiety, according to the teenagers and the Aggressive Behavior scale, according to teachers. The target of bullying students reported more internalizing behavior problems (F = 13.3, p = 0.001) and fewer externalizing behavior problems (F = 6.63, p = 0.013), when compared with their teachers. The presence of interparental conflict was more frequent in families of students bullied, reaching statistically significant difference between groups ( 2 = 4.2, p = 0.04). There was a slight and positive correlation between the scores of behavioral problems reported by students and the family adversity scores ( = 0.288, p = 0.001). While scores of behavior problems, especially internalizing, reported by victims of bullying were significantly higher than those reported by non-victims, and have reached clinical levels, the teachers do not seem to be sensitive to these indicators. Identify behavior problems and family characteristics associated with victimization, and to evaluate the perception of the involved and their teachers contribute to the development of preventive measures of bullying in Brazilian schools

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Syftet med denna studie är att generera kunskap om hur män hanterar motgångar. Genom att använda oss av en kvalitativ metod har vi utfört semistrukturerade intervjuer med fyra män, vilket gör att vi får vi tillgång till deras perspektiv på hantering av motgångar. Resultaten baseras sedan på männens svar vid intervjutillfällena och analyseras sedan utifrån de teoretiska ramverken KASAM (känsla av sammanhang) samt Illeris teori om lärande. Resultaten visar att männens sätt att hantera motgångar varierar, samtidigt som det går att urskilja faktorer som är gemensamma för samtliga män. Socialt stöd och personliga strategier är gemensamma faktorer, som i varierande grad återkommer i männens redogörelser för hur de har hanterat olika motgångar. Trots att socialt stöd är framtonande i det samlade intervjumaterialet, uppger tre av fyra män att de inte vänder sig till signifikanta andra när de mår som sämst. Orsaken till detta är att inte belasta omgivningen. Även alkoholbruk är i viss mån framträdande som ett sätt att tidigare hanterat motgångar på, men också som ett fortsatt tillvägagångssätt i enstaka fall. Samtliga av männen har funnit deras motgångar meningsfulla med tiden, och flera beskriver hur händelsen har varit ett skäl till att engagera sig i frågor och evenemang relaterad till respektive motgång. Gemensamt för männen var synen på motgångar som tvådimensionellt, vilket innebär att en händelse kan upplevas som utmanande alternativt ställas inför en händelse som är okontrollerbar. Resultaten synliggör även motgångar som å ena sidan något individen är delaktig i, och å andra sidan en oförutsedd händelse som individen exponeras inför. / The purpose of this study is to generate knowledge about how men handle adversity. By using aqualitative method, we conducted semi-structured interviews with four men, which gives us access totheir perspective on dealing with adversity. The results are then based on the men's responses to theinterviews and then analyzed on the basis of the theoretical frameworks SOC (sense of coherence) andIlleris theory of learning. The results show that men's ways of dealing with adversity vary, while it ispossible to distinguish factors that are common to all men. Social support and personal strategies arecommon factors, which recur to varying degrees in men's accounts of how they have dealt withvarious adversities. Despite the fact that social support is prominent in the collected interviewmaterial, three out of four men state that they do not turn to significant others when they feel theworst. The reason for this is not to strain the surroundings. Alcohol use is also to some extentprominent as a way of dealing with adversity in the past, but also as a continued approach inindividual cases. All of the men have found their adversity meaningful over time, and several describehow the event has been a reason to get involved in issues and events related to each adversity.Common to men was the view of adversity as two-dimensional, which means that an event can beperceived as challenging or faced with an event that is uncontrollable. The results also show adversityin which, on the one hand, something the individual is involved in, and on the other hand, anunforeseen event to which the individual is exposed.

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Social interaction deficits seen in psychiatric disorders emerge in early-life and are most closely linked to aberrant neural circuit function. Due to technical limitations, we have limited understanding of how typical versus pathological social behavior circuits develop. Using a suite of invasive procedures in awake, behaving infant rats, including optogenetics, microdialysis, and microinfusions, we dissected the circuits controlling the gradual increase in social behavior deficits following two complementary procedures-naturalistic harsh maternal care and repeated shock alone or with an anesthetized mother. Whether the mother was the source of the adversity (naturalistic Scarcity-Adversity) or merely present during the adversity (repeated shock with mom), both conditions elevated basolateral amygdala (BLA) dopamine, which was necessary and sufficient in initiating social behavior pathology. This did not occur when pups experienced adversity alone. These data highlight the unique impact of social adversity as causal in producing mesolimbic dopamine circuit dysfunction and aberrant social behavior.

Because adverse childhood and family of origin experiences may have implications for adult relationships, it is important to understand what can help buffer potential negative effects. The current study was designed to understand the relationship between childhood family of origin adversities, coming to terms with family of origin issues and events, and adult romantic relationship quality for African Americans (N = 1613). A path analysis was conducted using data from the RELATE assessment (see www.relate-institute.org). Results indicated that, taken together, coming to terms, self-esteem, and depression likely partially mediated the relationship between family of origin adversity and adult relationship quality. Results also suggested that if African Americans were able to come to terms, they reported less depression and higher levels of self-esteem. Clinicians may find it useful to focus on assisting African American individuals in coming to terms with childhood family of origin adversity as part of treatment for depression, self-esteem issues, and adult romantic relationship problems. Additional clinical implications and directions for future research are discussed.

En 2019, 31 % et 14 % des jeunes femmes et hommes mondialement ont déclaré de n’être pas engagé en emploi, en études ou en formation (NEET). Cette étude a examiné les voies de développement menant au statut NEET chez les jeunes adultes en étudiant l'association entre les adversités périnatales et le statut NEET et le rôle médiateur de comportements extériorisés. Les données proviennent de l'Étude Longitudinale du Développement des Enfant du Québec (ÉLDEQ, n = 974). L'analyse des classes latentes a identifié quatre profils d'exposition: faible adversité; adversité de la croissance fœtale, qui incluent les participants rencontrant des problèmes de croissance in utero et après la naissance ; les complications d’accouchement, qui incluent les participantes qui connaissent des complications pendant l'accouchement; l’adversité familiale, qui se compose de participants qui ont vécu l'adversité dans leur vie familiale. Les associations entre les profils périnatals, le statut NEET et le rôle médiateur présumé de comportements extériorisés ont été étudiées à l'aide de la modélisation par équation structurelle. Le risque de devenir NEET était plus élevé pour les enfants ayant subi une adversité familiale (OR = 3,19 [IC 95 % : 2,31-4,40], p < 0,001) et de croissance fœtale (2,03 [1,11-3,71], p = 0,022). Les problèmes d’extériorisation ont médié l'association entre l'adversité familiale et le statut de NEET (1,03 [1,01-1,06], p=0,003). La prévention du statut NEET devrait englober les facteurs de risque lié à la croissance fœtale et l’adversité familiale, qui peuvent aider les efforts de prévention pendant la période périnatale. / In 2019, 31% and 14% of young women and men worldwide – respectively – reported being Not engaged in Employment, Education, or Training (NEET), an important indicator of long-term socioeconomic vulnerability. This study examined the developmental pathways leading to NEET status in young adulthood by investigating the association between perinatal adversities and NEET status and the mediating role of externalizing behaviours. Data were from the Québec Longitudinal Study of Child Development (QLSCD, n = 974). Latent Class Analysis identified four profiles of exposures to 32 perinatal adversities: Low adversity, the reference profile; Fetal growth adversity, which includes participants experiencing adversity related to growth problems in utero and after birth; Delivery complications, which includes participants – or their mothers – who experience complications during birth; Familial adversity, consists of participants who experienced adversity related to their family life. The associations between the perinatal profiles, NEET status which was self-reported at age 21 years old and the putative mediating role of externalizing symptoms that were self-reported at age 15 and 17 were investigated using structural equation modeling. The risk of becoming NEET was higher for children who experienced perinatal familial (OR = 3.19 [95% CI: 2.31-4.40], p < 0.001) and fetal growth (2.03 [1.11-3.71], p = 0.022) adversity. Externalizing problems mediated the association between familial adversity and NEET status (1.03 [1.01-1.06], p=0.003). Prevention of NEET status in young adulthood should encompass familial and fetal growth- related risk factors, which can help inform early prevention efforts in the perinatal period.

The purpose of this study is to investigate in what ways volunteers at local youth empowerment organizations can contribute to the prevention of adversity and intimate partner violence among youths, as well as their perception of the needs of their target group. Another aim is to discuss the possibilities of cooperation between different agents working to support adolescents, which includes volunteers, schools, parents and other adults. This subject is relevant for social work as organizations in the nonprofit sector can be established as producers of welfare services. The investigation is conducted through qualitative thematic analyses of interviews with four volunteers from two different organizations, and the analysis is presented in three themes. The theoretical perspectives applied are street-level bureaucracy, ecological system theory, stigma, and gender theory. The empirical body describes both opportunities and limitations of the preventative work, and the result implies that no single agent has enough resources to decrease adolescents’ social vulnerability by their own means. Therefore, the possibility of cooperation between agents in various levels of the ecological system is discussed. The conclusion of this study is that all agencies need to contribute to create more effective prevention and support measures to reduce youth adversity and intimate partner violence, and volunteers can play a key role in this work.