As mudanças climáticas impõem um conjunto de desafios à sociedade contemporânea. Nesse sentido, esta dissertação trata das mudanças climáticas a partir da abordagem dos governos locais e, mais especificamente, da experiência da cidade de São Paulo. A política climática permitiu que o município paulistano exercesse um protagonismo no cenário nacional e regional, além de uma inserção internacional. A cidade promulgou em junho de 2009, antes do estado de São Paulo e da União, a lei que criou e institucionalizou sua política de mudança do clima. O recorte cronológico considerou os mandatos dos prefeitos Marta Suplicy (PT), de 2001 a 2004; José Serra (PSDB), de 2005 a 2006; Gilberto Kassab (PFL/DEM/PSD), de 2006 a 2012; e Fernando Haddad (PT), de 2013 a 2016. Esse período foi analisado a partir do referencial teórico da sociologia política, considerando especificamente a figura do mediador de políticas públicas e os instrumentos da ação pública. Em termos metodológicos foi realizada uma revisão bibliográfica não sistemática, pesquisas em legislações e periódicos da época e a aplicação de questionário semiestruturado em entrevistas com atores-chave. O questionamento central foi: o que permitiu que a cidade de São Paulo exercesse um protagonismo no campo das políticas públicas em mudanças climáticas no Brasil? A busca pela resposta a essa pergunta indicou que um conjunto de instrumentos da ação pública local começou a ser implementado pelo menos desde 2003 e, a partir do momento em que os valores das mudanças climáticas passaram a representar a principal referência das ações da Secretaria do Verde e Meio Ambiente (SVMA), uma série de ações intersetoriais ganharam força. Eduardo Jorge exerceu uma liderança importante nesse processo, sendo o Secretário de Meio Ambiente mais longevo. Entretanto, quando um novo governo assumiu o poder em São Paulo a partir de 2013, a política climática perdeu força e sofreu retrocessos. / The climate change imposes a set of challenges to the contemporary society. This dissertation considers the climate change from the local governments approach and, more specifically, the São Paulos city experience. The climate policy allowed the city to play a leading role at the national regional scenario, besides an international insertion. The city has promulgated in June 2009 the law that created and institutionalized its climate change policy, before the State of São Paulo and the Union. The period analyzed considered the mandates of mayors Marta Suplicy (PT) from 2001 to 2004, José Serra (PSDB) in 2005 and Gilberto Kassab (PFL/DEM/PSD) from 2006 to 2012, and Fernando Haddad (PT) from 2013 to 2016. This period was analyzed from the theoretical reference of the political sociology perspective, considering specifically the figure of the public policies mediator and public action instruments. The methodology adopted was based on non-systematic bibliographic review, researches in legislation and journals, and the application of semi structured questionnaire on interviews with key actors. What allowed the city of São Paulo to play a leading role in the field of public policies on climate change in Brazil? The quest for the answer to this question indicated that a set of local public action instruments have been in place since at least 2003 and, as climate change values have come to represent the main reference of SVMA actions, a series of intersetorial actions gained strength. Eduardo Jorge has an important leadership in this process, being the environmental secretary during the longer analyzed period. However, when the new São Paulos government takes place from 2013, climate change policy loses strength and has setbacks.

Made available in DSpace on 2016-04-28T18:24:12Z (GMT). No. of bitstreams: 1 Madalena de Souza Reis.pdf: 2520809 bytes, checksum: d677b252ef459fcaeced033c52eb06b9 (MD5) Previous issue date: 2009-11-23 / Secretaria da Educação do Estado de São Paulo / This research aims to investigate the role of mediator teacher (Vygotsky 2003, Freire 2007, Gomes 2002) in the teaching-learning process of reading, poems were used for formation of reader student. This study is justified by the needs of the reseacher-teacher (Pontecorvo 2005, André 2008, Bortoni-Ricardo, 2008) to seek answers to worrying questionings concerning the paradigm changes in education, demanding a new attitude, new performance and knowledge of the theoretical bases of reading teaching (Soares 1998, Kleiman 2002, Rojo 2006), and new reading practices in the classroom (Solé 1998, Pontecorvo, 2005). It is inserted in Applied Linguistics area, it aims to contribute to the construction and negotiation of multiple readings in the classroom (Zanotto 1995, Moita Lopes 2006) ; cognitive and interactive process of reading (Kato 2007, Kleiman 2004 ) and reading as a social practice. Data had been collected through experiences carried out in a school with a focus group composed of high school students from public schools. The think aloud in group (Zanotto, 1995) is a technique or method of research and at the same time an educational experiences that contributed significantly to the co-construction of meanings. This study demonstrates the value of literacy teaching (Michelletti 2006, Cosson, 2007) and the key role of the mediator teacher along the construction of knowledge and the teacher s vocational training (Perrenoud 2002, Kay 2007). Three poems of Brazilian literature poets were selected (Alphonsus de Guimaraens, Cruz e Souza e Castro Alves) / Esta pesquisa tem como cerne investigar o papel do professor mediador (Vygotsky 2003, Freire 2007, Gomes 2002) no processo ensino-aprendizagem da leitura utilizando poemas para a formação do aluno leitor. Justifica-se esta pesquisa a necessidade de o professor-pesquisador refletir sobre suas ações (Pontecorvo 2005, André 2008, Bortoni-Ricardo, 2008) e buscar respostas a inquietantes questionamentos diante das mudanças paradigmáticas na educação, exigindo uma nova postura, nova atuação e conhecimento das bases teóricas do ensino de leitura (Soares 1998, Kleiman 2002, Rojo 2006) e novas práticas de leitura em sala de aula. Inserida na área da Linguística Aplicada, esta pesquisa busca contribuir para a construção e negociação de múltiplas leituras em sala de aula (Zanotto 1995, Moita Lopes 2006); o processo cognitivo e interativo da leitura (Kato 2007, Kleiman 2004 ) e a leitura como prática social (Solé 1998, Pontecorvo, 2005). Os dados da pesquisa foram constituídos por vivências realizadas na escola com um grupo focal composto por alunos do ensino médio da rede pública. O pensar alto em grupo (Zanotto, 1995) é uma técnica ou método de pesquisa e ao mesmo tempo uma vivência pedagógica que contribuiu, significativamente, para a co-construção de sentidos. A pesquisa tenta mostrar a importância da valorização do letramento literário (Michelletti 2006, Cosson, 2007) e o papel fundamental do professor mediador na construção do conhecimento e a formação do professor (Perrenoud 2002, Kay 2007). Foram selecionados três poemas de poetas da literatura brasileira (Alphonsus de Guimaraens, Cruz e Souza e Castro Alves)

Made available in DSpace on 2016-04-28T19:58:56Z (GMT). No. of bitstreams: 1 Teresa Cristina Aliperti Franca Domingues.pdf: 1821169 bytes, checksum: 9d50bd3b3b9b69843f50efd0900c22ff (MD5) Previous issue date: 2015-10-26 / Starting from the importance of the formation of literary reader, this study aims to discuss the literary text reading practices in the classroom in the elementary school and the role of the teacher - mediator in this process. Initially we established the dialogue between the practices that I have developed in the classroom and those proposed by the Reading and Writing Program from the Government of the State of São Paulo, in order to highlight the concepts that underlie these two practices. Later, the role of the teacher- mediator is analyzed in the process of the formation of the literary reader and suggested proposals are identified which can be developed in the process. To theoretically support the research, we turn to authors such as Candido, Freire, Petit, Barthes, Smith, Perrone-Moisés, Calvino, Dios, Bajour and Castrillón, who guided our reflection. The thesis is organized into three chapters: "Reading and literary text: the reader's formation", which addresses the conceptions of reading, literature, literary text, literary literacy and literary reader, concepts which are also present at Reading and Writing Program of the Government of the State of Sao Paulo, "Literary text reading practices in the classroom: dialogues with the Reading and Writing Program", in which we present the practices of reading proposed by the program that dialogue with my own practices developed in the classroom, and " The mediator role in the formation of the literary reader", which discusses his/hers decisive role in the formation of the literary reader and suggests literary text reading practice in the classroom. It also discusses how the teacher needs to understand that the work begins with the written text, but it is essential to go beyond it, that is, give voice to the student, to turn him/her into an author, not only of a written text, but based on his/her own history, giving opportunity to him/her to be autonomous, reflect, develop critical thinking and become an effective citizen / Partindo da relevância da formação do leitor literário, o presente estudo objetiva discutir as práticas de leitura do texto literário em sala de aula no Ensino Fundamental I e o papel do professor-mediador nesse processo. Inicialmente, estabelecemos o diálogo entre as práticas que desenvolvo e aquelas propostas pelo Programa Ler e Escrever, do Governo do Estado de São Paulo, de forma a evidenciar as concepções que permeiam tais práticas. Posteriormente, questiona-se o papel do professor-mediador no processo de formação do leitor literário e sugerem-se propostas que podem ser desenvolvidas nesse processo. Para fundamentar teoricamente a pesquisa, recorremos a autores como Candido, Freire, Petit, Barthes, Smith, Perrone-Moisés, Calvino, Dios, Bajour, Castrillón, os quais nortearam nossa reflexão. A dissertação está organizada em três capítulos: Leitura e texto literário: a formação do leitor , que aborda as concepções de leitura, literatura, texto literário, letramento literário e leitor literário, concepções essas também presentes na proposta de leitura do Programa Ler e Escrever; Práticas de leitura do texto literário em sala de aula: diálogos com o Programa Ler e Escrever , no qual apresentamos as práticas de leitura propostas pelo Programa que dialogam com as práticas que desenvolvo em sala de aula, e "O papel do mediador no processo de formação do leitor literário", que discute o papel decisivo do professor-mediador no processo de formação do leitor, bem como sugere práticas de leitura do texto literário em sala de aula. Discute-se, também, como o professor necessita entender que o trabalho começa com o texto escrito, mas é fundamental ir além, ou seja, dar voz ao aluno para transformá-lo em autor, não apenas de um texto escrito, mas de sua própria história, dando oportunidade ao sujeito de ser autônomo, refletir, desenvolver o senso crítico e, desta forma, tornar-se efetivamente cidadão

Le Médiateur (MED) est un complexe multi-protéique dont le principal rôle est de transmettre à la machinerie transcriptionnelle de base les différents signaux fournis par les facteurs fixés sur des séquences d’ADN spécifique , permettant ainsi une régulation fine de l’expression des gènes. Des mutations dans le MED ou ses partenaires, comme NIPBL, sont à l’origine de diverses maladies telles que des malformations congénitales, des troubles neuro développementaux ou des cancers.A partir de cellules provenant de patients portant différentes mutations dans les sous-unités MED12 ou MED17 du MED ou dans NIPBL, nous avons observé une altération du niveau d’expression de certains gènes qui dépend de la localisation de la mutation et de la nature de leur activation. Ces variations de l’expression des gènes sont la conséquence d’un défaut dans la formation du complexe de transcription et du remodelage de la chromatine (modifications post-traductionnelles des histones). Outre une meilleure appréhension du rôle des sous-unités MED12 et MED17 du MED ainsi que NIPBL, sur la transcription des gènes, ma thèse a permis de mieux comprendre l’étiologie des maladies associées à une mutation dans ces protéines. / Mediator (MED) is a multi-protein complex whose main role is to convey to basal transcriptional machinery the different signals from factors bound at specific DNA sequences , allowing thus a fine regulation of gene expression. Mutations in MED or its partners, like NIPBL, cause various diseases, such as congenital malformations, neurodevelopmental disorders or cancers. Using cells from patients carrying different mutations in the MED subunits, MED12 or MED17, or in NIPBL, we observed an alteration of the expression of studied genes which depend on the position of the mutation and on the nature of the activation. These variations of gene expression are the consequence of a defect in transcription complex formation, as well as in chromatin remodeling(post-translational histones modifications). In addition to better comprehend the role of the MED subunits MED12 and MED17, and of NIPBL on gene transcription, my thesis helped to better understand the ethiology of the disorders associated with mutations in these proteins.

Submitted by Rosina Valeria Lanzellotti Mattiussi Teixeira (rosina.teixeira@unisantos.br) on 2019-01-31T12:22:09Z No. of bitstreams: 1 ALEXANDER MARQUES DA SILVA.pdf: 34972733 bytes, checksum: bcc26ada89ddb8111f5d296953bb32dd (MD5) / Made available in DSpace on 2019-01-31T12:22:09Z (GMT). No. of bitstreams: 1 ALEXANDER MARQUES DA SILVA.pdf: 34972733 bytes, checksum: bcc26ada89ddb8111f5d296953bb32dd (MD5) Previous issue date: 2018-12-17 / Esta dissertação apresenta um pouco da vida e obra de uma das figuras acadêmicas importantes da sociedade santista e que foi o líder da criação da Universidade Católica de Santos, Waldemar Valle Martins. Um homem preocupado com a educação e crente do poder transformador desta na vida do ser humano. Por ter lutado pela implantação da primeira Universidade da Baixada Santista e por sua importância para a cidade de Santos, o objetivo deste trabalho é o de apresentar sua trajetória como educador e intelectual, além de preservar e manter viva sua memória. Esta pesquisa é qualitativa e, para analisar o perfil desse homem, foi utilizada como metodologia a histórico documental, sendo realizado um levantamento de seus escritos. Apesar de haver muitas fontes primárias, como documentos oficiais e pessoais, escritos, fotos, esses não eram suficientes para se analisar seus diferentes papéis na sociedade santista. Por isso, utilizou-se também da metodologia da história oral, através de entrevistas com pessoas que estudaram e trabalharam com ele, procurando obter mais informações a respeito desse intelectual. Foram realizadas 35 entrevistas, utilizando-se de um questionário semiestruturado, que confirmaram a sua importância para a educação na cidade de Santos, haja vista que ele empenhou-se por um ensino superior de qualidade, preparando professores para lecionarem através de cursos. Destaca-se também seu papel como intelectual dentro e fora da Universidade. O conceito de análise utilizado é o de intelectual mediador, desenvolvido por Ângela de Castro Gomes e Patrícia Hansen. Além desse, utiliza-se o conceito de intelectual e sua rede de sociabilidade, de Jean François Sirinelli. As entrevistas confirmaram que Waldemar foi um intelectual por seu trabalho no campo educacional e social, mediante seus escritos na mídia impressa e de suas aulas ministradas nas Universidades em que lecionou. Tais atuações atestam sua importância para a formação intelectual de seus ex-alunos e ex-paroquianos. Diante do que foi apresentado pode-se concluir que Waldemar Valle Martins foi um relevante intelectual mediador, visto que sua atuação através de sua rede de sociabilidade e influência junto ao Conselho Federal de Educação, contribuiu efusivamente para a implantação da Universidade Católica de Santos, um marco educacional importante para a cidade de Santos e região. / This dissertation presents a bit of the life and work of one of the important academic figures of the Santos society and who was the creation leader of the Catholic University of Santos, Waldemar Valle Martins. A man concerned with education and a believer of this transforming power in the life of the human being. For having fought for the implantation of the first University of Baixada Santista and for your importance for the city of Santos, the objective of this work is to present your trajectory as educator and intellectual, besides preserving and keeping alive your memory. This research is qualitative and, to analyze the profile of this man, was used as methodology the historical documentary, being carried out a survey of his writings. Although there were many primary sources, such as official and personal documents, writings, photos, these were not enough to analyze their different roles in the society of Santos. For this reason, it also used oral history methodology, through interviews with people who studied and worked with him, seeking more information about this intellectual. Thirty-five interviews were carried out using a semi-structured questionnaire, which confirmed its importance for education in the city of Santos, considering that it was committed to quality higher education, preparing teachers to teach through courses. His role as an intellectual inside and outside the University is also highlighted. The concept of analysis used is that of a mediator, developed by Ângela de Castro Gomes and Patricia Hansen. In addition to this, the concept of intellectual and his network of sociability, by Jean François Sirinelli, is used. The interviews confirmed that Waldemar was an intellectual for his work in the educational and social field, through his writings in the print media and his classes taught at the universities where he taught. These performances attest to its importance for the intellectual formation of your alumni and former parishioners. In view of what was presented, it can be concluded that Waldemar Valle Martins was a relevant mediating intellectual, since his work through his network of sociability and influence with the Federal Council of Education contributed effusively to the implementation of the Catholic University of Santos, a an important educational landmark for the city of Santos and the region.

Made available in DSpace on 2016-04-27T17:26:59Z (GMT). No. of bitstreams: 1 Andrei Venturini Martins.pdf: 1778229 bytes, checksum: 55fe21833ba1001bae979fbe899bfda2 (MD5) Previous issue date: 2011-11-11 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The main goal of this inquiry is to analyze the issue of human condition after the Adamic Fall, according to Blaise Pascal. We have chosen his Lettre that dates from October 17th, 1651, as our main object of analysis. This Lettre is anything but a marginal text within the author s work, representing, on the contrary, the debut of several meditations on themes such as death, compassion, providence, consolation, sacrifice, original sin, self-love, the infinite emptiness, the horror of death before and after the Fall, the love of live before and after the Fall. Our departing hypothesis is that, according to Blaise Pascal, man lives on attempting to deflect the infinite emptiness that dwell in him and fill it somehow, even though only Jesus Christ, as a mediator, is capable of fulfilling the void left by God. To sustain this hypothesis, two major concepts - that of self-love and that of infinite emptiness - present in the foresaid Lettre shall be analyzed throughout the two parts that form this research: A Theory of Original Sin and its Consequences and The Infinite Emptiness of man without God . In Part I, the focus is on the Jansenist spiritual direction of the XVIIth century, and its implications with regards to our object (First chapter). The second chapter focuses on the concepts of Self-Love and Infinite Emptiness, and there we raise the question whether, to Pascal, self-love as detachment from God is the root of all evil and all vices, and whether it is the cause of the infinite emptiness that dwells in man. Apart from Self-Love and Infinite Emptiness, the Lettre also mentions the will to domination and laziness as other consequences of the Adamic Fall. At the end of the first part (Third chapter), we intend to demonstrate the consequences of the Fall as Pascal puts them in the Écrits sur la Grâce: ignorance, concupiscence, guilt and eternal death. Thus, we shall have a more thorough perspective on the consequences of the Fall - something we shall name subjective collage , since we bring the Lettre near to the Écrits sur la Grâce and compose a picture with the consequences of the Fall. In Part II, titled The Infinite Emptiness of man without God , we have elaborated two chapters in order to meditate about human condition based on the concept of infinite emptiness. Chapter IV (the first in Part II) focuses on the relation between infinite emptiness and the Pascalian concept of divertissement; finally, the fifth and last chapter brings the concept of infinite emptiness near to that of Christ as Mediator / O principal objetivo desta pesquisa é analisar a condição humana depois da Queda Adâmica em Blaise Pascal, tendo como objeto central a Lettre de 17 de outubro de 1651. Este texto não pode ser considerado um texto marginal na obra do filósofo francês, mas sim o início de inúmeras reflexões temáticas como a morte, a compaixão, a providência, a consolação, o sacrifício, o pecado original, o amor próprio, o vazio infinito, o horror da morte antes e depois da queda, o amor pela vida antes e depois da queda. A hipótese que norteia este trabalho é que o homem tenta desviar-se e preencher esse vazio infinito causado pela queda através do divertissement, mas só o Cristo Mediador pode ocupar o vazio que Deus deixou. Para demonstrá-la, são investigados dois conceitos capitais na Lettre o Amor Próprio e o Vazio Infinito , ao longo das duas partes que compõem este trabalho: Teoria do pecado original e suas consequências e O Vazio Infinito do homem sem Deus . Na primeira, é investigado o contexto da direção espiritual jansenista no século XVII e seus ecos na Lettre, o que constitui o capítulo I; é trabalhado o conceito de Amor Próprio e Vazio Infinito, no capítulo II, com o intuito de saber se para Pascal o amor próprio desligado de Deus está na raiz de todos os males e de todos os vícios, assim como a causa do vazio infinito no homem sem Deus, pois, além do amor próprio e do vazio infinito, encontra-se na Lettre o desejo de dominação e a preguiça como consequências da queda; e, para finalizar a primeira parte, no capítulo III, são mostradas as consequências da queda expressas nos Écrits sur la Grâce, como a ignorância, a concupiscência, culpa e morte eterna, para que se possa ter, assim, uma visão mais completa, o que foi denominado, neste trabalho, colagem subjetiva , em função da aproximação da Lettre aos Écrits sur la Grâce. Na segunda parte, elaborada em dois capítulos, a fim de refletir a condição humana a partir do conceito de vazio infinito, é estudada, de forma específica, a relação do vazio infinito e o divertissement e, no último capítulo, o mesmo conceito de vazio infinito é aproximado ao Cristo Mediador

Chez les eucaryotes, la synthèse des ARN messagers (ARNm) est un processus hautement régulé en réponse à la fixation d’activateurs spécifiques sur des régions régulatrices. Cette étape permet le recrutement de co-activateurs, des facteurs généraux de la transcription (GTFs) et de l’ARN polymérase II (Pol II) pour former le complexe de préinitiation (PIC). Le Médiateur est un complexe co-activateur essentiel à ce processus et bien qu’il ait fait l’objet de nombreuses études ces dernières années, sa complexité a empêché de parvenir à une compréhension détaillée de son mécanisme de fonctionnement in vivo. Au cours de ma thèse, je me suis intéressée à la sous-unité Med17 qui joue un rôle central au sein du module de tête du Médiateur et interagit directement avec la Pol II. Nous avons construit une collection de mutants thermosensibles de cette sous-unité chez la levure Saccharomyces cerevisiae, que nous avons ensuite caractérisés par différentes approches de biologie moléculaire et génomique fonctionnelle. Nos analyses par ChIP-seq montrent que le Médiateur influence indépendamment le recrutement et/ou la stabilisation de la TBP ainsi que des modules cœur et kinase de TFIIH sur le génome. Ces résultats indiquent que, contrairement à la séquence d’assemblage linéaire observée in vitro, l’assemblage du PIC in vivo est un processus à plusieurs étapes non-séquentielles et que le Médiateur est important pour orchestrer l’arrivée des différents composants du PIC. Par ailleurs, nous avons mis en évidence un contact direct entre le Médiateur et Rad2/XPG, une endonucléase qui intervient dans la réparation de l’ADN. Une analyse à l’échelle du génome a révélé que cette protéine est présente sur les gènes de classe II, en absence de stress génotoxique et que sa localisation génomique corrèle avec celle du Médiateur. Nous avons ainsi démontré que le Médiateur est important pour le recrutement de Rad2, suggérant un nouveau rôle pour ce complexe dans la réparation de l’ADN, en plus de son rôle de co-activateur dans la transcription par la Pol II. / In eukaryotes, the synthesis of messenger RNA (mRNA) is highly regulated in response to the binding of specific activators to regulatory regions. This step allows the recruitment of coactivators, general transcription factors (GTFs) and RNA polymerase II (Pol II) to form the preinitiation complex (PIC). Mediator is a co-activator complex essential to this process and although it has been studied intensively during the last few years, its complexity has precluded a detailed understanding of the molecular mechanisms of its function in vivo. During my PhD, I focused on the Med17 subunit which plays a central role within the Mediator head module and interacts directly with Pol II. We obtained a large collection of temperature-sensitive mutants of this subunit in the yeast Saccharomyces cerevisiae, and then characterized these mutants by different molecular biology and functional genomics approaches. Our ChIP-seq analyses show that Mediator influences independently the recruitment and/or the stabilization of TBP as well as TFIIH core and kinase modules on the genome. These results indicate that, unlike a linear sequence observed in vitro, in vivo the PIC assembly is a non-sequential multistep process and that Mediator is important to orchestrate the recruitment of different PIC components. Furthermore, we identified a direct contact between Mediator and Rad2/XPG, an endonuclease involved in DNA repair. A genome-wide analysis reveals that this protein is present on class II genes in the absence of genotoxic stress, and that its genomic localization correlates with that of Mediator. We thus demonstrated that Mediator is important for Rad2 recruitment, suggesting a new role for this complex in DNA repair, in addition to its co-activator role in Pol II transcription.

As mudanças climáticas impõem um conjunto de desafios à sociedade contemporânea. Nesse sentido, esta dissertação trata das mudanças climáticas a partir da abordagem dos governos locais e, mais especificamente, da experiência da cidade de São Paulo. A política climática permitiu que o município paulistano exercesse um protagonismo no cenário nacional e regional, além de uma inserção internacional. A cidade promulgou em junho de 2009, antes do estado de São Paulo e da União, a lei que criou e institucionalizou sua política de mudança do clima. O recorte cronológico considerou os mandatos dos prefeitos Marta Suplicy (PT), de 2001 a 2004; José Serra (PSDB), de 2005 a 2006; Gilberto Kassab (PFL/DEM/PSD), de 2006 a 2012; e Fernando Haddad (PT), de 2013 a 2016. Esse período foi analisado a partir do referencial teórico da sociologia política, considerando especificamente a figura do mediador de políticas públicas e os instrumentos da ação pública. Em termos metodológicos foi realizada uma revisão bibliográfica não sistemática, pesquisas em legislações e periódicos da época e a aplicação de questionário semiestruturado em entrevistas com atores-chave. O questionamento central foi: o que permitiu que a cidade de São Paulo exercesse um protagonismo no campo das políticas públicas em mudanças climáticas no Brasil? A busca pela resposta a essa pergunta indicou que um conjunto de instrumentos da ação pública local começou a ser implementado pelo menos desde 2003 e, a partir do momento em que os valores das mudanças climáticas passaram a representar a principal referência das ações da Secretaria do Verde e Meio Ambiente (SVMA), uma série de ações intersetoriais ganharam força. Eduardo Jorge exerceu uma liderança importante nesse processo, sendo o Secretário de Meio Ambiente mais longevo. Entretanto, quando um novo governo assumiu o poder em São Paulo a partir de 2013, a política climática perdeu força e sofreu retrocessos. / The climate change imposes a set of challenges to the contemporary society. This dissertation considers the climate change from the local governments approach and, more specifically, the São Paulos city experience. The climate policy allowed the city to play a leading role at the national regional scenario, besides an international insertion. The city has promulgated in June 2009 the law that created and institutionalized its climate change policy, before the State of São Paulo and the Union. The period analyzed considered the mandates of mayors Marta Suplicy (PT) from 2001 to 2004, José Serra (PSDB) in 2005 and Gilberto Kassab (PFL/DEM/PSD) from 2006 to 2012, and Fernando Haddad (PT) from 2013 to 2016. This period was analyzed from the theoretical reference of the political sociology perspective, considering specifically the figure of the public policies mediator and public action instruments. The methodology adopted was based on non-systematic bibliographic review, researches in legislation and journals, and the application of semi structured questionnaire on interviews with key actors. What allowed the city of São Paulo to play a leading role in the field of public policies on climate change in Brazil? The quest for the answer to this question indicated that a set of local public action instruments have been in place since at least 2003 and, as climate change values have come to represent the main reference of SVMA actions, a series of intersetorial actions gained strength. Eduardo Jorge has an important leadership in this process, being the environmental secretary during the longer analyzed period. However, when the new São Paulos government takes place from 2013, climate change policy loses strength and has setbacks.

Depression is a serious public health concern and leading cause of global disability; in the U.S., it is estimated that over 35 million individuals suffer from depression. Health-related dysfunction, including impairment and poor quality of life, are often associated with depressive symptoms; however, little research has examined the interrelationships between these factors. Functional impairment, or the experience of difficulty conducting necessary activities of daily living, may contribute to emotional distress directly but may also impact perceived quality of life. Health-related quality of life (HRQL), which is conceptualized as a holistic and subjective perception of one’s physical and mental quality of life, is a wellestablished indicator of overall general health. Given the dearth of research examining the linkages between these variables, we hypothesized that greater levels of functional impairment would be positively related to depressive symptoms and that physical and mental HRQL would mediate this association, such that greater functional impairment would be associated with poorer mental and physical HRQL and, in turn, to greater depressive symptoms. Our sample (N=100; 70.3% female (N=71); 93% Caucasian (N=94); Mean Age = 42.18, SD = 12.83) was recruited from a rural, Southern Appalachian primary care clinic serving working and uninsured patients. Participants completed self-report measures: Instrumental Activities of Daily Living Scale, World Health Organization Quality of Life Scale - Brief, and the Center for Epidemiological Studies Depression Scale. Simple mediation analyses, consistent with Preacher and Hayes, were conducted covarying age, sex and ethnicity. In support of our hypothesis, the direct effect of functional impairment on depressive symptoms decreased but remained significant (DE=-1.39, SE=.66, p=.03) when mental HRQL was included as a mediator (IE lower 95% CI=-3.27, upper 95% CI=-.877), indicating partial mediation. In addition, the direct effect of functional impairment on depressive symptoms fell out of significance (DE=-1.18, SE=.33, p=.15) when physical HRQL was included as a mediator (IE lower 95% CI=-3.79, upper 95% CI=-.83), indicating full mediation. Our findings suggest that individuals experiencing functional limitations are less likely to report good mental and physical HRQL and, in turn, endorse higher levels of depressive symptoms. Our findings may have clinical implications; therapeutic enhancement of coping skills and problem-solving strategies may reduce psychological distress, whereas engagement with social and instrumental support networks may provide assistance with physical limits, thereby reducing risk for depressive symptoms in individuals experiencing functional impairment.

L’objet de ce travail de recherche est de s’interroger sur la dialectique entre la professionnalisation et la mondialisation du rugby à XV et l’évolution des ancrages territoriaux qui en découle, en fonction du modèle sportif qui est propre à chaque terrain d’investigation sélectionné : la Bretagne, le Munster et la Géorgie. L’enjeu est de démontrer dans quelle mesure la professionnalisation des organisations et des acteurs sportifs est le moteur à la fois de la globalisation rugbystique et de nouvelles logiques oligopolistiques de différentiation territoriale du rugby, aux différentes échelles spatiales. S’étant diffusée au sein des championnats domestiques amateurs, cette professionnalisation provoque des dynamiques au profit des territoires sportifs les plus compétitifs et les mieux intégrés au reste du monde rugbystique globalisé, tout en étant le vecteur d’identités territoriales spécifiques. Le choix des trois terrains d’enquête résulte de la pertinence de s’interroger sur l’articulation entre les modèles sportifs et les ancrages territoriaux pour appréhender chaque modèle de production d’espace rugbystique, et sur les formes spécifiques d’ancrage territorial de la pratique du rugby, en considérant celui-ci comme un médiateur territorial. Pour chaque terrain d’enquête, tout en procédant par itération, la mise en oeuvre de la méthode de la triangulation permet d’approfondir et de mettre à l’épreuve les concepts mobilisés. Trois grandes approches de l’analyse socio-spatiale du sport sont privilégiées : l’approche structurelle, l’approche systémique, et celle qui donne de l’importance au rôle des acteurs. / The aim of this research work is to wonder about the dialectic between the professionalization and the globalization of the rugby union, and the evolution of the resulting territorial anchorages, depending on the specific sporting model of the investigation lands that have been selected: Brittany, Munster and Georgia. The issue is to demonstrate to what extent the professionalization of the organizations and the sporting actors is at the same time the driving force of the rugby globalization and of new rugby territorial differentiations’ oligopolistic logics, on various levels in geographic terms. Being diffused into the domestic amateur championships, this professionalization stimulates dynamics in favor of the much competitive sporting territories and the best integrated to the rest of the globalized world, while being the vector of specific territorial identities. The selection of the three investigation lands stems from the relevantness of the interrogation on the link between the sporting models and the territorial anchorages to comprehend each model of rugby territorial production and the specific forms of the territorial anchorage of the rugby practice, considering this sport as a territorial mediator. For each investigation land, while proceeding by iteration, the triangulation method implemented allows to go deeper and to test the concepts that have been mobilized. Three major socio spatial analysis approaches have been focused: the structural approach, the systemic approach and the approach that highlights the actors’ role.