This thesis is classified as an internal experimental project whose aim is to design HW and low level SW of simplified version of the controller for TFE731 turbofan engine according to defined requirements. The expected outputs in addition to the system design is also information about possible technical problems and difficulties arising during the analysis and development of the system. The work covers a brief look into the history of aviation and avionics, theoretical analysis turbofan engine, analysis of measured and controlled variables. Based on the requirements analysis and I/O values is made circuit design (HW) and design of the low level control software.

Les micro-ARNs (miRNAs) sont des ARNs de 20-22 nucléotides, transcrits à partir du génome, dont la fonction est de réguler l’expression génique en s’appariant à des ARNm cibles, inhibant ainsi leur traduction et/ou entrainant leur dégradation. Dans les cancers, l’expression des miRNAs est fortement dérégulée. Une majorité de miRNAs est diminuée dans les tissus tumoraux par rapport aux tissus normaux, et un lien causal a été décrit entre inhibition globale des miRNAs et tumorigenèse. Par ailleurs, des miRNAs agissant comme des suppresseurs de tumeurs et d’autres comme des oncogènes ont été décrits. Dans ce contexte impliquant de plus en plus les miRNAs dans les pathologies néoplasiques, l’objectif de ce travail était d’étudier le rôle de la voie miRNA dans la biologie des cellules tumorales. Afin d’identifier des cellules tumorales dépendant de miRNAs oncogènes endogènes pour survivre ou proliférer, nous avons développé une stratégie d’inhibition globale de la biogenèse des miRNAs en ciblant Drosha ou DGCR8, les deux composants du microprocesseur, complexe nucléaire de maturation des miRNAs. Cette stratégie nous a permis d’identifier des lignées cellulaires tumorales dans lesquelles l’inhibition du microprocesseur conduit à un phénotype d’arrêt de prolifération durable. Nous avons mis à profit cette dépendance à la voie miRNA pour réaliser un crible positif de complémentation du défaut de prolifération observé grâce à l’expression de miRNAs individuels. Nous avons ainsi pu mettre en évidence des miRNAs capables de soutenir individuellement la prolifération de ces cellules tumorales. Cette stratégie nous a également permis de montrer des différences fonctionnelles entre miRNAs homologues ou de la même famille. La recherche des cibles régulées par ces miRNAs nous a permis d’élaborer des hypothèses concernant les cibles potentiellement impliquées dans le phénotype observé. Nous avons ainsi démontré la participation du suppresseur de tumeur PTEN à l’arrêt de prolifération induit par l’inhibition du microprocesseur. La stratégie d’inhibition globale de la voie miRNA suivie d’une complémentation phénotypique par des miRNAs individuels permet de s’affranchir de la grande redondance de séquence et de fonction des miRNAs et devrait pouvoir s’appliquer d’une manière plus générale à l’étude d’autres processus régulés par les miRNAs. / MicroRNAs (miRNAs) are 20-22 nucleotides RNAs, transcribed from the genome, which regulate gene expression by base-pairing to target mRNAs, thus inhibiting their translation and/or leading to their degradation. In cancers, miRNAs expression is strongly deregulated. A majority of miRNAs is diminished in tumoral tissues compared to normal tissues, and a causal link has been established between global inhibition of the miRNA pathway and tumorigenesis. In addition, miRNAs acting like tumor suppressors or oncogenes have been described. In this context of growing evidences implicating miRNAs in neoplasic diseases, this work aimed to investigate the role played by miRNA pathway in the biology of tumoral cells. In order to identify tumoral cells depending on endogenous oncogenic miRNAs to proliferate or survive, we developed a strategy of global inhibition of miRNAs biogenesis by targeting Drosha or DGCR8, the two components of the “microprocessor”, the nuclear miRNA maturation complex. This strategy allowed us to identify tumoral cell lines in which microprocessor inhibition led to a sustained growth arrest. We took advantage of this miRNA pathway dependency to screen for individual miRNAs able to complement the observed growth defect. This complementation screen allowed us to identify individual miRNAs able to sustain growth in those tumoral cells. This strategy also highlighted functional differences between homologous miRNAs or between miRNAs from the same family. The search for targets regulated by those miRNAs allowed us to develop hypothesis concerning the potential targets involved in the observed phenotype. By using this approach, we demonstrated that the tumor suppressor PTEN was involved in the growth arrest induced by microprocessor inhibition. The strategy of global miRNA pathway inhibition followed by phenotypic complementation by individual miRNAs allows overcoming the high sequence and function redundancy of miRNAs. We thus think it could be applied more generally to the study of other cellular processes regulated by miRNAs.

<p>This report briefly describes the special requirements for a computer board for use in space. In particular, component selection and ways of mitigating the soft and hard errors are discussed. Furthermore, one implementation for a low-cost, relatively high performance computer that will work in the harsh space environment is presented. The report is primarily intended for those familiar with digital design, who need an introduction to construction of space or other high-reliability hardware. </p><p>As the quality (resolution) of imagers, spectrometers and other data sources in scientific satellite payloads is increasing, there is also an increasing demand for more processing power in order to compress or in other way process the data before transmitting it on the limited bandwidth microwave downlink to Earth. Scientific instruments are usually mission specific and have rather low budget, so there is a need for a powerful computer board that can be used for a number of missions in order to keep the engineering costs down.</p>

Clustered architecture processors are preferred for embedded systems because centralized register file architectures scale poorly in terms of clock rate, chip area, and power consumption. Scheduling for clustered architectures involves spatial concerns (where to schedule) as well as temporal concerns (when to schedule). Various clustered VLIW configurations, connectivity types, and inter-cluster communication models present different performance trade-offs to a scheduler. The scheduler is responsible for resolving the conflicting requirements of exploiting the parallelism offered by the hardware and limiting the communication among clusters to achieve better performance. Earlier proposals for cluster scheduling fall into two main categories, viz., phase-decoupled scheduling and phase-coupled scheduling and they focus on clustered architectures which provide inter-cluster communication by an explicit inter-cluster copy operation. However, modern commercial clustered architectures provide snooping capabilities (apart from the support for inter-cluster communication using an explicit MV operation) by allowing some of the functional units to read operands from the register file of some of the other clusters without any extra delay. The phase-decoupled approach of scheduling suffers from the well known phase-ordering problem which becomes severe for such a machine model (with snooping) because communication and resource constraints are tightly coupled and thus are exposed only during scheduling. Tight integration of communication and resource constraints further requires taking into account the resource and communication requirements of other instructions ready to be scheduled in the current cycle while binding an instruction, in order to carry out effective binding. However, earlier proposals on integrated scheduling consider instructions and clusters for binding using a fixed order and thus they show different widely varying performance characteristics in terms of execution time and code size. Other shortcomings of earlier integrated algorithms (that lead to suboptimal cluster scheduling decisions) are due to non-consideration of future communication (that may arise due to a binding) and functional unit binding. In this thesis, we propose a pragmatic scheme and also a generic graph matching based framework for cluster scheduling based on a generic and realistic clustered machine model. The proposed scheme effectively utilizes the exact knowledge of available communication slots, functional units, and load on different clusters as well as future resource and communication requirements known only at schedule time to attain significant performance improvement without code size penalty over earlier algorithms. The proposed graph matching based framework for cluster scheduling resolves the phase-ordering and fixed-ordering problem associated with scheduling on clustered VLIW architectures. The framework provides a mechanism to exploit the slack of instructions by dynamically varying the freedom available in scheduling an instruction and hence the cost of scheduling an instruction using different alternatives to reduce the inter-cluster communication. An experimental evaluation of the proposed framework and some of the earlier proposals is presented in the context of a state-of-art commercial clustered architecture.

Silizide spielen ein wesentliche Rolle in den technologisch fortschrittlichsten CMOS Bauteilen. Sie finden Verwendung als Kontaktmaterial auf den Aktivgebieten und dem Silizium Gatter von Transistoren. Diese Arbeit beschäftigt sich mit den Systemen: Co-Si, Co-Ni-Si und Ni-Si. Sowohl in situ Hochtemperatur-SR-XRD Experimente als auch CBED wurden zur Phasenidentifikation herangezogen. AES erlaubte es, Elementverteilungen in Schichtstapeln zu bestimmen. Für Studien über Agglomerationserscheinungen wurde REM eingesetzt. TEM und analytisches TEM trugen nicht nur zu Einblicken in Schichtstrukturen und Kornformen bei, sondern lieferten auch Daten zu Elementverteilungen in Silizidschichten. Diese Dissertation gliedert sich in zwei Hauptteile. Der erste Teil beschäftigt sich mit den Phasenbildungsabfolgen und den Phasenbildungs- und Umwandlungstemperaturen in nanoskaligen dünnen Schichten. Als Trägermaterial wurden einkristalline und polykristalline Siliziumsubstrate verwendet. Der Einfluß verschiedener Dotierungen im Vergleich zu undotierten Substraten sowie die Beeinflussung der Silizidierung durch eine Deckschicht wurden untersucht. Im zweiten Teil waren Größeneffekte verschiedener Schichtdicken und Agglomerationserscheinungen Gegenstand von Untersuchungen. Unterschiede bei der Silizidierung in Zusammenhang mit unterschiedlichen Schichtdicken wurden bestimmt. Darüberhinaus wurde eine ternäre CoTiSi Phase gefunden und identifiziert. Außerdem konnte die stark eingeschränkte Mischbarkeit der Monosilizide CoSi und NiSi gezeigt werden. Der thermische Ausdehnungskoeffizient von NiSi im Temperaturbereich 400?700°C und sein nicht-lineares Verhalten wurden bestimmt. / Silicides are an essential part of state-of-the-art CMOS devices. They are used as contact material on the active regions as well as on the Si gate of a transistor. In this work, investigations were performed in the systems Co-Si, Co-Ni-Si, and Ni-Si. In situ high temperature SR-XRD and CBED techniques were used for phase identification. AES enabled the determination of elemental concentrations in layer stacks. SEM was applied to agglomeration studies. TEM imaging and analytical TEM provided insights into layer structures, grain morphology as well as information about the distribution of chemical elements within silicide layers. This thesis is divided into two main parts. The first part deals with the phase formation sequences and the phase formation and conversion temperatures in nanoscale thin films on either single crystal or polycrystalline Si substrates. The effect of different types of dopants vs. no doping and the impact of a capping layer on the phase formation and conversion temperatures were studied. In the second part, size effects and agglomeration of thin silicide films were investigated. The effect of different layer thicknesses on the silicidation process was studied. Additionally, the degree of agglomeration of silicide films was calculated. Furthermore, the ternary CoTiSi phase was found and identified as well as the severely limited miscibility of the monosilicides CoSi and NiSi could be shown. The CTE of NiSi between 400?700 ±C and its non-linear behavior was determined.

With the emergence of the concept of Smart Grid (SG), the Power Distribution Systems are undergoing major changes in the way it is operated, studied and analyzed. The breakthrough technology of measurement, automation, control and telecommunication equipment, together with the reduction of the costs of acquisition and implementation, allowed Brazilian electric utilities to invest in automation, control and telecommunication, facing distribution networks. This technological development applied in the networks allows new studies and new methodologies to be developed and implemented by utilities in order to improve their technical and operational performance. Many studies are being conducted in order to propose automatic reconfiguration in the distribution networks, automatic restoration and distribution management system in real time, aiming to optimize the loads distribution, reduce energy losses, improve system reliability and the quality indicators of power supply, among other possible needs of the distribution company. Nowadays a fairly explored point is the switching through automatic devices, which have criteria and assumptions for execution in the network. Among the criteria and assumptions, there is the guarantee of coordination and selectivity of protective devices involved in the reconfiguration after switching and consequent topological change. The need for analysis of protective devices and possible reparameterization of them, justifies the development of a methodology through computational solution, able to analyze the coordination and selectivity of the devices (microprocessor reclosers) after network changes. It is due to this niche opportunities caused by technological development and changes in operating philosophy of distribution networks, that this dissertation has as main objective to develop a methodology to validate the operation condition of protective devices, ensuring the safety and system reliability and proposing new protection settings when needed, which consequently will allow network reconfigurations. / Com o surgimento do conceito de Smart Grid (SG), os Sistemas de Distribuição de Energia vêm sofrendo grandes modificações em sua forma de operação, estudo e análise. O grande avanço tecnológico dos equipamentos de medição, automação, controle e telecomunicação, aliado à redução dos custos de aquisição e implementação, permitiu que as distribuidoras brasileiras de energia elétrica realizassem grandes investimentos em automação, controle e telecomunicação, voltados para redes de distribuição. Este avanço tecnológico aplicado nas redes permite que novos estudos e novas metodologias sejam desenvolvidos e aplicados pelas concessionárias, a fim de melhorar o seu desempenho técnico operacional. Muitos estudos estão sendo realizados com o intuito de propor reconfigurações automáticas nas redes de distribuição, recomposição automática e gerenciamento do sistema em tempo real, sempre com o objetivo de otimizar a distribuição das cargas, reduzir as perdas de energia, melhorar a confiabilidade do sistema e os indicadores de qualidade do fornecimento de energia, entre outras possíveis necessidades da respectiva distribuidora. Atualmente um ponto bastante explorado são os chaveamentos através de dispositivos automatizados, os quais possuem critérios e premissas para efetivação em campo. Dentre os critérios e premissas, destaca-se a garantia da coordenação e seletividade dos equipamentos de proteção envolvidos na reconfiguração após a realização do chaveamento e consequente mudança topológica. A necessidade de análise dos dispositivos de proteção e possível reparametrização dos mesmos justifica o desenvolvimento de uma metodologia através de solução computacional, capaz de analisar a coordenação e seletividade dos dispositivos (religadores microprocessados), após mudanças na rede. É devido a este nicho de oportunidades causadas pelo desenvolvimento tecnológico e pelas mudanças na filosofia de operação das redes de distribuição, que esta dissertação tem por objetivo principal desenvolver uma metodologia que permita validar a condição de operação dos dispositivos de proteção, garantindo a segurança e a confiabilidade do sistema e propondo novos ajustes de proteção quando necessário, o que consequentemente permitirá reconfigurações de rede.

This report briefly describes the special requirements for a computer board for use in space. In particular, component selection and ways of mitigating the soft and hard errors are discussed. Furthermore, one implementation for a low-cost, relatively high performance computer that will work in the harsh space environment is presented. The report is primarily intended for those familiar with digital design, who need an introduction to construction of space or other high-reliability hardware. As the quality (resolution) of imagers, spectrometers and other data sources in scientific satellite payloads is increasing, there is also an increasing demand for more processing power in order to compress or in other way process the data before transmitting it on the limited bandwidth microwave downlink to Earth. Scientific instruments are usually mission specific and have rather low budget, so there is a need for a powerful computer board that can be used for a number of missions in order to keep the engineering costs down.

Le déploiement des répéteurs iso-fréquence est une solution économique pour étendre la couverture d’un émetteur principal aux zones d’ombre. Cependant, ce mode de déploiement fait apparaître le phénomène des échos radio-fréquence entre antennes d’émission et de réception du répéteur. Selon les standards, un écho aussi faible soit-il réduit le débit de la liaison radio, tandis qu’un écho fort fait courir au répéteur le risque d’endommager ses circuits électroniques, ces risques sont dûs aux ondulations de puissance créées par les échos. L’objectif de cette thèse à caractère industriel est d’étudier ce phénomène naturel en considérant des signaux provenant de différents standards des télécommunications. Cette étude permet une caractérisation des échos radio-fréquence pour mieux s’orienter vers une solution optimisée et industriellement réalisable.Nous nous sommes orientés vers la solution du traitement du signal avancé en favorisant le filtrage adaptatif pour sa rapidité de convergence et sa simplicité relative d’implantation matérielle. Les circuits reconfigurables sont retenus pour leur prix et leur souplesse. L’implantation des solutions est effectuée en virgule fixe afin de satisfaire les exigences de réactivité. Durant la mise en oeuvre de la solution anti-écho, nous avons proposé une multitude de solutions numériques souples et fiables. À partir de ce constat, notre partenaire industriel a décidé de généraliser ce mode de traitement par le développement, la fabrication et la commercialisation de répéteurs de nouvelle génération entièrement numériques. / On-frequency repeaters are a cost-effective solution to extend coverage and enhance wireless communications, especially in shadow areas. However, coupling between the receiving antenna and the transmitting antenna, called radio frequency echo, increases modulation errors and creates oscillations in the system when the echo power is high. According to the communication standards, extremely weak echoes decrease the transmission rate, while strong echoes damage electroni ccircuits because of power peaks. This thesis aims at characterizing the echo phenomenon under different modulations, and proposing an optimized solution directly integrated to industry. We have turned to digital solutions especially the adaptive because of their high convergence rate and their simplicity to be implemented. The programmable circuits are chosen for their attractive price and their flexibility. When implementing echo cancellation solution, we proposed several reliable solutions, showing that digital processing is much more beneficial. For this reason, digital solutions are generalized, and the new generation of repeaters is fully digital.

Syfte: Syftet  med  studien var  att undersöka  om  det  finns  en skillnad  i  livskvalité mellan  individer  med  transfemoral  amputation  som använder  mikroprocesstyrd knäkomponent (MPK) respektive mekanisk knäkomponent (Mek.). Design: Tvärsnittsstudie Försökspersoner: 14 protesbrukare  med unilateral transfemoral amputation (10 män, 4 kvinnor; 4 Mek., 10 MPK), amputerade på grund av trauma, kongenital orsak, infektion eller tumör och som använt sig av samma typ av knäled i minst ett år. Metod: För  att  studera  livskvalité  i  målpopulationen  genomfördes  en enkätundersökning bestående av RAND-36 samt kompletterande frågor. Deltagarna fördelades i två grupper med avseende på knäkomponent för att möjliggöra analys av resultaten. Resultat: Ingen signifikant  skillnad  i livskvalité uppmättes mellan  grupperna. De största  skillnaderna observerades  dock  i  den fysiska-  (Mek.:  0 MPK:  50) och emotionella (Mek.: 41,75 MPK: 100) rollfunktionen. Slutsats: Resultatet  i  studien  visade  ingen  signifikant  skillnad i  livskvalité mellan grupperna. Vidare  bör  mer  specifika  mätinstrument,  inriktade  mot  individer  med amputation, användas för att undersöka livskvalité i målpopulationen. / Purpose: The purpose of the study was to investigate if there is a difference in qualityof  life  (QoL)  between  individuals  with  a  transfemoral  amputation  usingmicroprocessor-controlled  knee  components  (MPK)  versus  mechanical  kneecomponents (Mech.). Design: Cross-sectional study Subjects: 14 prosthesis users with a unilateral transfemoral amputation  (10 men, 4women; 4 Mech., 10 MPK), amputated due to trauma, congenital reasons, infection ortumor and used the same prosthetic knee for at least one year. Method: To study QoL in the  population concerned a questionnaire was carriedout, including the RAND-36 and supplementary questions. The  participants  were divided into two groups with regard to the knee component to enable the results to be analyzed. Results: No significant difference in QoL were found between the groups. The largest differences were observed in physical (Mech.: 0 MPK: 50) and emotional (Mech.: 41.75MPK: 100) role function. Conclusion: The result of the study showed no significant difference in QoL between the groups. Furthermore, specific measuring instruments targeting individuals with amputation should be used to investigate quality of life in the population concerned.

This report presents a final degree project in mechanical engineering which was performed at Ball Beverage Packaging Fosie AB, Malmoe. The goal of the project was to create a system that could estimate the amount of paint available in a machine that colorizes aluminum cans. The environment that the system was mounted in is demanding and has high requirements on strength, stability and toughness against splashes of ethanol and water-based paint. Moreover, the company initially demanded that the project only used existing holes on the machine for adding equipment. In order to choose a measurement technology for the system, literature studies were performed on laser, ultrasonic devices and weight measurement. These studies were the foundation for a concept analysis using a Pugh’s matrix.Furthermore, with the help of the Pugh’s matrix, the project was directed towards estimating the amount of paint by measuring the weight using load cells. The collected data was supposed to be handled by an Arduino uno R3 board. Following the decision of a direction, seven concepts were designed in Autodesk Inventor with regards to mounting in existing positioning pin-holes.The last concept was manufactured with own hands – under supervision – by processing aluminum rods. Parallel to the manufacturing, the electronic system was programmed and tested by both step-wise removing identical weights, and a by measuring a continuous weight decrease caused by water escaping from a container with holes. The results of these tests showed that the system could perform the desired function.The result of the manufactured concept confirmed that the system could work with the machine but the position in the positioning pin-hole was not optimal as the forces were too low. By creating a provisional mount and testing the system beneath the paint container, it was concluded that the position accumulated more forces. This resulted in an approved modification of the container holder for a permanent mount of the load cell. Followed by this, a large amount of tests showed that the system had good potential of working with the machine but a mount beneath the container was not good as friction from mounting screws had great effect on the read values. / Rapporten behandlar ett kandidatarbete i maskinteknik som utfördes på Ball Beverage Packaging Fosie AB, Malmö. Syftet med arbetet var att skapa ett system för uppskattning av färgmängd i en maskin som färglägger aluminiumburkar. Miljön som systemet monterades i ställde höga krav på hållfasthet, tillförlitlighet och motståndskraft mot stänk från etanol och vattenbaserad färg. Initialt ställde företaget preliminära krav på att endast existerande hål på färgverket fick användas. För att välja givare till systemetutfördes litteraturstudier med avseende på laser, ultraljud och viktavläsning, vilket låg till grund för konceptvalsanalys med en Pughsmatris.Med hjälp av Pughsmatrisen riktades projektet in på att uppskatta färgmängden genom viktavläsning med lastceller, vars data skulle hanteras av ett Arduino uno R3 kort. Detta efterföljdes av att sju koncept skapades i Autodesk Inventor för infästning i existerande sprinthål på kisthållaren. Det sista konceptet tillverkades genom att på egen hand – under uppsikt –maskinbearbeta aluminiumstavar. Parallellt med tillverkningen programmerades och testades elektroniken med stegvis borttagning av vikt och kontinuerligt avrinnande vatten från hålig behållare, vars resultat visade på att systemet klarar den tänkta funktionen. Resultatet av det maskintillverkade konceptet visade att systemet även fungerade på färgverket men att positionen i sprinthålet inte var optimal då för lite krafter upptogs. Genom att tillverka en provisorisk monteringssats och testa systemet monterat under färgkistan påvisades att denna position tog upp avsevärt mer kraft. Detta medförde att kisthållaren maskinbearbetades för permanent montering av lastcell. Ett stort antal olika tester efter slutlig montering visade att systemet har goda möjligheter för att fungera med färgläggningsmaskinen men att montering under kisthållaren inte var lämplig eftersom friktion från bland annat inspänningsskruvar hade betydandeinverkan på de avlästa värdena.