Conclusions: In the same number of people treated, the number of CVD events avoided for the overall risk approach is always larger than that of the blood pressure approach. The additional benefits of overall risk approach compared with the blood pressure approach decreases as the percentage of people from the total population is increased. If the current practice and hypertension guidelines in China are shifted to the overall risk approach, many more CVD events could be avoided with the same resources used. / Methods: The sample used in the analyses includes a subsample of 38,673 persons from the 2002 China National Nutrition and Health Survey, who were 30-74 years old, without previous CVD, and had data on all major CVD risk factors. CVD risks of the patients selected by each approach are predicted using suitable risk prediction equation. The RRR of anti-hypertensive drug treatment derived from meta-analyses of RCTs. The difference in the absolute effectiveness between the two approaches is used to quantify how many more CVD events can be prevented in 1000 people treated by the ORA as compared to the BPA. / Objective: To estimate and compare the number of major cardiovascular events that could be avoided by shifting the blood pressure approach to the overall risk approach if the same percentage of people in a large, representative Chinese population is treated with anti-hypertensive drugs. / Results: When 2.5%, 5.5%, 10.1%, 15.5%, 20.7%, 25.7% or 33.0% of the 38,673 subjects were treated by anti-hypertensive drugs by using the two approaches respectively, 22 (95%CI: 17∼28), 13 (11∼16), 9 (8∼10), 7 (6∼8), 6 (5∼7), 5 (4∼6), or 4 (3∼4) more CVD events could be avoided in every 1000 people treated if the blood pressure approach is shifted to the overall risk approach, which is in general a 15% to 25% increase in CVD events prevented. / Qin, Ying. / Adviser: Jin Ling Tang. / Source: Dissertation Abstracts International, Volume: 73-02, Section: B, page: . / Thesis (Ph.D.)--Chinese University of Hong Kong, 2010. / Includes bibliographical references (leaves 116-121). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [201-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese.

Morbidity due to noncommunicable diseases (NCDs) has become a worldwide epidemic. As a result, the United Nations (2015) Sustainable Developmental Goals (SDGs) included goal (3.4) that aims to reduce the premature mortality from NCDs by one third. All countries, regardless of income, are required to develop strategies and achieve a reduction in the burden of NCDs. This study, conducted in the Sultanate of Oman, aimed to explore individuals' knowledge, perceptions, actions and intentions to modify their lifestyle to reduce their risk of stroke. The Health Belief Model (HBM) was used as the underpinning theoretical framework to provide a broader conceptual understanding of the Omani sociocultural and structural influences on individuals' lifestyles. A convergent mixed methods design within a realist social constructionism methodology was used. Both quantitative (344 questionnaires) and qualitative (10 interviews) data were integrated using a narrative weaving approach. The study results confirm that both agency and structure influenced the adoption of healthy behaviours in Oman. The study indicates that the study participants are likely to engage in health-related behaviours when they perceived the benefit of such a course of actions in term of it reducing their risk of stroke. The study found that in the Omani setting, individual factors such as fear, family experience and physical sickness, the psychological status of chronic conditions and a cost-benefit analysis of the behaviour influence the individuals' decisions to practise a healthy lifestyle. The major finding in the study showed that perceptions of risk vary among individuals who share the same culture and religion, particularly individual perception of religious belief was found to influence their susceptibility to stroke risk. In addition, the study identified some sociocultural and structural factors that influenced the individuals' decisions to engage in a healthy lifestyle. This study presents an extended HBM to incorporate the role of individual religious beliefs as an individual factor. The study suggests that health improvement plans are needed in Oman to develop both individual- and community- level interventions to achieve the target of SDGs for NCDs.

Les maladies cardiovasculaires sont la première cause de mortalité dans le monde, en lien notamment avec la présence et la rupture de plaques d’athérome. Afin d’éviter la survenue d’évènements aigus, un traitement par statines peut être proposé. Cependant, leur utilisation engendre un risque d’effets délétères. Afin de réduire ce risque, une réduction des doses utilisées pourrait être envisagée. Ce travail de thèse étudie les effets potentiels d’un traitement à très faible dose d’atorvastatine et à long terme sur un modèle animal : le lapin Watanabe. Des mesures ont été menées sur des individus contrôles et traités de 3 à 12 mois. Le suivi de la lipidémie et des principaux facteurs biochimiques, de l’adhésion et de l’inflammation a été fait au niveau sanguin. Le développement de l’athérosclérose a été évalué en tomographie par cohérence optique (OCT). Des mesures en histologie ont permis de valider un classement proposé avec l’OCT et de quantifier les macrophages intra plaques. L’élasticité artérielle a été testée in vivo par la mesure de la vitesse de l’onde de pouls et in vitro par un test de traction statique. La fonction vasculaire a été appréhendée en vasoréactivité sur différents territoires (aorte, carotide, mésentérique). Le contenu en élastine et collagène de la paroi des vaisseaux a été effectué en microscopie à deux photons et génération de seconde harmonique. Enfin la respiration mitochondriale du myocarde et sa susceptibilité aux ROS a été évaluée sur fibres cardiaques perméabilisées, l’activité de systèmes antioxydants enzymatiques mesuré, ainsi que la peroxydation lipidique. Les résultats montrent des effets bénéfiques de ce traitement à très faible dose d’atorvastatine sur la fonction cardiovasculaire indépendamment d’un effet hypolipidémiant. / Cardiovascular diseases are the first worldwide causes of death, associated to the presence and rupture of atherosclerotic plaques. To limit acute events, statins may be prescribed. However, its use leads to deleterious effects risk. To reduce this risk, a dose reduction could be considered. The work of this thesis is to study potential effects of a very low dose of atorvastatin, taken in the long term, in an animal model: the Watanabe rabbit. Measurements are made on control and treated animals from the age of 3 to 12 months. Circulating lipids, biochemical parameters and parameters of adhesion and inflammation were studied. Atherosclerosis evolution was evaluated by optical coherence tomography (OCT). Histological measurements allowed to validate a ranking proposed with OCT observations and to quantify intra-plaque macrophage content. Arterial stiffness was tested in vivo with pulse wave velocity and in vitro with a static tensile test. Vascular function was approached with vasoreactivity in different territories (aorta, carotid, mesenteric). Elastin and collagen contents of the artery wall were determined with two-photon and second harmonic generation microscopy. Finally, mitochondrial respiration and its susceptibility to ROS were evaluated in permeabilized cardiac fibers, any enzymatic antioxidant systems and lipid peroxidation were measured. Results show beneficial effects of this very low dose atorvastatin treatment in cardiovascular function, independently of a lipid-lowering effect.Keywords: atherosclerosis,

Submitted by Mayara Moura Alves da Cruz (maya_bilac@hotmail.com) on 2019-01-29T13:55:00Z No. of bitstreams: 1 2019_01_29_Defesa completa_Mayara.pdf: 926024 bytes, checksum: 393a4084a126093e2a4b297e3c5595a0 (MD5) / Approved for entry into archive by ALESSANDRA KUBA OSHIRO ASSUNÇÃO (alessandra@fct.unesp.br) on 2019-01-29T17:20:17Z (GMT) No. of bitstreams: 1 cruz_mma_me_prud.pdf: 926024 bytes, checksum: 393a4084a126093e2a4b297e3c5595a0 (MD5) / Made available in DSpace on 2019-01-29T17:20:17Z (GMT). No. of bitstreams: 1 cruz_mma_me_prud.pdf: 926024 bytes, checksum: 393a4084a126093e2a4b297e3c5595a0 (MD5) Previous issue date: 2018-12-14 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Introdução: apesar dos benefícios da reabilitação cardiovascular (RCV) para as doenças cardiovasculares, a baixa aderência dos pacientes é uma preocupação. Ela pode estar relacionada a diversos fatores, dentre eles, à motivação e ao engajamento ao tratamento. Terapias alternativas podem melhorar motivação, engajamento e assim refletir em melhor aderência. Nesse contexto, a terapia baseada em realidade virtual (TRV) surge como uma opção para cardiopatas, contudo nesse grupo de pacientes é necessário um maior controle dos parâmetros hemodinâmicos, visto que se ultrapassados podem causar maior risco à saúde. Objetivo: investigar engajamento, motivação, barreiras e aderência frente a aplicação de TRV em cardiopatas ou pacientes com fatores de risco que participam regularmente da RCV e avaliar suas repercussões hemodinâmicas agudas. Métodos: foram recrutados participantes de um programa de RCV e alocados de forma randomizada para as intervenções RCV ou RCV+TRV. As intervenções foram realizadas por 12 semanas. Sendo o desfecho primário a avaliação o engajamento (escala de engajamento), motivação (Behavioral Regulation in Exercise Questionnaire 3), barreiras (escala de barreiras para reabilitação cardíaca) e aderência dos pacientes (frequência registrada no prontuário). O desfecho secundário foi a avaliação das repercussões hemodinâmicas agudas antes, durante e após uma sessão por meio da pressão arterial (PA), frequência cardíaca (FC), FC de reserva, frequência respiratória (f), saturação de oxigênio e percepção subjetiva de esforço (PSE). Análise estatística: foi avaliada a homogeneidade dos dados (teste de esfericidade de Mauchley) seguida da correção de Greenhouse-Geisser, quando necessário. Posteriormente foi utilizada Anova Two-Way para medidas repetidas, p<0,05. Resultados: Os pacientes de ambos os grupos apresentaram um perfil com baixas barreiras, alto engajamento e motivação e os resultados demonstram que a TRV promoveu um aumento na aderência dos pacientes que apresentavam baixa aderência à RCV convencional, porém esse aumento não se manteve após 12 semanas da interrupção do protocolo. Em relação à análise dos dados hemodinâmicos, a TRV apresentou um padrão de respostas hemodinâmicas agudas fisiológicas semelhante à RCV. Porém houve maior magnitude durante sua execução e até 5min da recuperação após a interrupção da sessão para as variáveis de FC, f e PSE (p<0,01), observados nos momentos de repouso, até um minuto, até três minutos e até cinco minutos da recuperação respectivamente em relação à TRV. Observou-se ainda que 74,07% dos pacientes que realizaram a TRV atingiram a FC de reserva em algum momento da sessão e as respostas de FC e PSE, sugerem que a TRV promoveu maior intensidade de esforço. Conclusão: A inserção da TRV ao RCV convencional aumentou a aderência após admissão de pacientes que participavam com frequência insatisfatória, o que não aconteceu com os pacientes do programa de RCV convencional, entretanto, a aderência volta a valores próximos dos iniciais após doze semanas do fim da intervenção. Porém, a TRV não estimulou a motivação e nem influenciou as barreiras e engajamento dos pacientes. Em relação aos dados hemodinâmicos, a TRV promoveu respostas agudas fisiológicas e semelhantes à RCV, mas com maior magnitude para algumas variáveis durante a sua execução e até cinco minutos da recuperação após a interrupção da sessão. / Introduction: there is a concern regarding to the low adherence of patients in cardiovascular rehabilitation (CR), despite their benefits. It may be related to several factors, among them, motivation and engagement to treatment. Alternative therapies can improve motivation, engagement reflecting in better adherence and, in this context, virtual reality based therapy (VRBT) appears as an option for cardiac patients. However, in this population, a greater control of hemodynamic parameters is necessary, once if exceed they can cause a greater risk to health. Objective: to investigate engagement, motivation, barriers and adherence through the application of VRBT in patients with cardiovascular diseases or patients with risk factors who regularly participate in CR. In addition, to evaluate their acute hemodynamic repercussions. Methods: participants of CR program were randomized to CR or CR+ VRBT. The interventions were performed for 12 weeks. The primary endpoint was engagement (User Engagement Scale), motivation (Behavioral Regulation in Exercise Questionnaire 3), barriers (Cardiac Rehabilitation Barriers Scale), and patient’s adherence (frequency recorded on the chart). The secondary endpoint was the acute hemodynamic repercussions before, during and after a session through blood pressure (BP), heart rate (HR), HR reserve, respiratory rate (rr), oxygen saturation and rate of perceived exertion (RPE). Statistical analysis: homogeneity of the data had been evaluated (Mauchley sphericity test) followed by the Greenhouse-Geisser correction, if necessary. After this, Anova Two-Way for repeated measures had been analyzed, p <0.05. Results: In both groups, patients had low barriers, high engagement and motivation. The results demonstrate that VRBT promoted an increase in adherence of patients with low adherence to conventional CR, but this increment was not maintained after 12 weeks of protocol interruption. Regarding the analysis of hemodynamic data, VRBT produce physiological acute hemodynamic responses similar to CR. However, there was a greater magnitude during its execution and until 5 minutes of recovery after session for the HR, rr and RPE (p <0.01), observed at rest, up to one, three and five minutes of recovery respectively in relation to VRBT. It was also observed that 74.07% of the patients who underwent VRBT reached HR reserve of training at some point in the session and the HR and RPE responses, suggesting VRBT promoted greater effort intensity. Conclusion: The insertion of VRBT to the conventional CR increased adherence after admission in patients who participated with unsatisfactory frequency, what did not happen with the patients in the conventional CR program, however, adherence returns to basal values after 12 weeks of the program. In addition, VRBT did not stimulated motivation and neither influence patients’ barriers and engagement. Regarding hemodynamic data, VRBT produce physiological acute hemodynamic responses similar to CR, although with greater magnitude for some variables during its execution and up to five minutes after session. / FAPESP: 2017/12254-8 / CAPES: 001

Ho Hing Man. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2001. / Includes bibliographical references (leaves 140-156). / Abstracts in English and Chinese. / Chapter Chapter 1 --- General introduction / Chapter 1.1 --- History of soybean --- p.1 / Chapter 1.2 --- Health benefits of soybean --- p.2 / Chapter 1.3 --- Introduction to flavonoids --- p.2 / Chapter 1.4 --- Bioavailability of flavonoids from foods --- p.3 / Chapter 1.5 --- Pharmacological effects of flavonoids and their glycosides --- p.4 / Chapter 1.5.1 --- Anticarcinogenic activity --- p.4 / Chapter 1.5.2 --- Antioxidative activity --- p.7 / Chapter 1.5.3 --- Cardioprotective activity --- p.9 / Chapter 1.5.4 --- Osteoprotective activity --- p.10 / Chapter 1.5.5 --- Neuroprotective activity --- p.12 / Chapter 1.5.6 --- Antiangiogenic activity --- p.12 / Chapter 1.6 --- Soy leaves --- p.13 / Chapter Chapter 2 --- Isolation and purification of kaempferol glycosides and genistin in soy leaves / Chapter 2.1 --- Introduction --- p.14 / Chapter 2.2 --- Objectives --- p.15 / Chapter 2.3 --- Materials and Methods --- p.16 / Chapter 2.3.1 --- Extraction and isolation --- p.16 / Chapter 2.3.1.1 --- Preparation of soy leaves butanol extract --- p.16 / Chapter 2.3.1.2 --- Preparation of kaempferol glycosides from soy leaves butanol extract --- p.16 / Chapter 2.3.2 --- High performance liquid chromatography (HPLC) analysis --- p.19 / Chapter 2.3.2.1 --- Sample preparation for the HPLC analysis --- p.19 / Chapter 2.3.2.2 --- HPLC analysis --- p.19 / Chapter 2.3.2.3 --- Quantification of the flavonoids and their glycosides --- p.23 / Chapter 2.3.2.4 --- Change in flavonoids and their glycosides in soy leaves --- p.23 / Chapter 2.4 --- Results --- p.24 / Chapter 2.4.1 --- Compound 1 --- p.24 / Chapter 2.4.2 --- Compound 2 --- p.24 / Chapter 2.4.3 --- Compound 3 --- p.25 / Chapter 2.4.4 --- Compound 4 --- p.25 / Chapter 2.4.5 --- Compound 5 --- p.25 / Chapter 2.4.6 --- Compound 6 --- p.26 / Chapter 2.4.7 --- Quantification of flavonoids in soybean and soy leaves --- p.32 / Chapter 2.4.8 --- Age-dependent changes in flavonoids and their glycosides --- p.32 / Chapter 2.5 --- Discussion --- p.35 / Chapter 2.5.1 --- Compound 1 --- p.35 / Chapter 2.5.2 --- Compound 2 --- p.35 / Chapter 2.5.3 --- Compound 3 --- p.37 / Chapter 2.5.4 --- Compound 4 --- p.38 / Chapter 2.5.5 --- Compound 5 --- p.39 / Chapter 2.5.6 --- Compound 6 --- p.40 / Chapter 2.5.7 --- Age-dependent changes in flavonoids and their glycosides --- p.40 / Chapter Chapter 3 --- Hypolipidemic effects of soy leaves in hamsters / Chapter 3.1 --- Introduction --- p.41 / Chapter 3.1.1 --- Different lipoproteins and their functions --- p.41 / Chapter 3.1.2 --- Risk factors of cardiovascular disease --- p.42 / Chapter 3.1.3 --- Animal model --- p.43 / Chapter 3.2 --- Objectives --- p.44 / Chapter 3.3 --- Materials and Methods --- p.45 / Chapter 3.3.1 --- Animals --- p.46 / Chapter 3.3.2 --- Serum lipid and lipoprotein determinations --- p.46 / Chapter 3.3.3 --- Determination of cholesterol in the liver and adipose tissue --- p.46 / Chapter 3.3.4 --- Extraction of neutral and acidic sterols from fecal samples --- p.49 / Chapter 3.3.4.1 --- Determination of neutral sterols --- p.49 / Chapter 3.3.4.2 --- Determination of acidic sterols --- p.50 / Chapter 3.3.4.3 --- GLC analysis of neutral and acidic sterols --- p.51 / Chapter 3.3.5 --- Statistics --- p.51 / Chapter 3.4 --- Results --- p.54 / Chapter 3.4.1 --- Growth and food intake --- p.54 / Chapter 3.4.2 --- "Effects of SLP and SLEE supplementation on serum triacylglycerol (TG), total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C)" --- p.54 / Chapter 3.4.3 --- Effects ofSLP and SLEE supplementation on non-HDL-C and ratio of non-HDL-C to HDL-C --- p.55 / Chapter 3.4.4 --- Effects of SLP amd SLEE supplementations on concentration of hepatic cholesterol --- p.58 / Chapter 3.4.5 --- Effects of SLP and SLEE supplementations on perirenal adipose tissue cholesterol --- p.58 / Chapter 3.4.6 --- Effects of SLP and SLEE supplementations on fecal neutral and acidic sterols --- p.61 / Chapter 3.5 --- Discussion --- p.64 / Chapter Chapter 4 --- Effects of soy leaves and its flavonoid glycosides on haemolysis and on LDL oxidation / Chapter 4.1 --- Introduction --- p.67 / Chapter 4.1.1 --- Role of low density lipoprotein oxidation in the development of atherosclerosis --- p.68 / Chapter 4.1.2 --- LDL oxidation --- p.70 / Chapter 4.1.3 --- Thiobarbituric acid reactive substances (TBARS) as an index of LDL oxidation --- p.71 / Chapter 4.1.4 --- Antioxidant and LDL oxidation --- p.74 / Chapter 4.2 --- Objective --- p.75 / Chapter 4.3 --- Materials and methods --- p.76 / Chapter 4.3.1 --- Isolation of LDL from human serum --- p.76 / Chapter 4.3.2 --- LDL oxidation --- p.77 / Chapter 4.3.3 --- Determine the formation of thiobarbituric acid-reactive substances (TBARS) --- p.77 / Chapter 4.3.4 --- Assay for erythrocyte haemolysis --- p.78 / Chapter 4.3.5 --- Statistics --- p.79 / Chapter 4.4 --- Results --- p.80 / Chapter 4.4.1 --- Effects of three different soy leaves extracts and flavonoid glycosides on LDL oxidation --- p.80 / Chapter 4.4.2 --- Effects of three soy leaves extracts and flavonoid glycosides on erythrocyte haemolysis --- p.80 / Chapter 4.5 --- Discussion --- p.85 / Chapter Chapter 5 --- Relaxing effects of soy leaves and its flavonoids / Chapter 5.1 --- Introduction --- p.89 / Chapter 5.1.1 --- Smooth muscle contraction --- p.90 / Chapter 5.1.1.1 --- Sliding filament mechanism --- p.91 / Chapter 5.1.2 --- Intracellular mechanisms involved in the regulation of smooth muscle contraction --- p.92 / Chapter 5.1.2.1 --- Voltage-gated Ca2+ channels --- p.92 / Chapter 5.1.2.2 --- Protein kinase C (PKC) mediated smooth muscle contraction --- p.93 / Chapter 5.1.2.3 --- Thromboxane A2 receptor-mediated calcium channel --- p.94 / Chapter 5.2 --- Objectives --- p.96 / Chapter 5.3 --- Materials and methods --- p.97 / Chapter 5.3.1 --- Drugs preparation --- p.97 / Chapter 5.3.2 --- Vessel preparation --- p.97 / Chapter 5.3.3 --- Contraction experiments --- p.99 / Chapter 5.3.3.1 --- Relaxant responses of soy leaves butanol extract on the contraction induced by different constrictors --- p.99 / Chapter 5.3.3.2 --- Relaxant responses of soy leaves butanol extract on U46619 and PGF2a- induced contraction --- p.99 / Chapter 5.3.3.3 --- "Relaxant responses of genistein, genistin and the kaempferol glycosides on U46619-induced contraction" --- p.100 / Chapter 5.3.4 --- Statistics --- p.100 / Chapter 5.4 --- Results --- p.102 / Chapter 5.4.1 --- Effect of soy leaves butanol extract --- p.102 / Chapter 5.4.2 --- Role of endothelium in extract-induced relaxation --- p.102 / Chapter 5.4.3 --- Effect of the soy leaves butanol extract on contractile response to prostaglandins --- p.103 / Chapter 5.4.4 --- Effects of kaempferol glycosides and kaempferol --- p.111 / Chapter 5.4.5 --- Effects of genistein and genistin --- p.111 / Chapter 5.5 --- Discussion --- p.118 / Chapter Chapter 6 --- Effect of soy leaves on mammary tumor / Chapter 6.1 --- Introduction --- p.123 / Chapter 6.1.1 --- Carcinogenesis --- p.123 / Chapter 6.1.1.1 --- In itiation --- p.124 / Chapter 6.1.1.2 --- Promotion --- p.124 / Chapter 6.1.1.3 --- Progression --- p.125 / Chapter 6.2 --- Objective --- p.126 / Chapter 6.3 --- Materials and methods --- p.127 / Chapter 6.3.1 --- Animal --- p.127 / Chapter 6.3.2 --- Determination of estrus cycle --- p.128 / Chapter 6.3.3 --- Statistics --- p.129 / Chapter 6.4 --- Results --- p.131 / Chapter 6.4.1 --- Incident rate of tumor induction --- p.131 / Chapter 6.4.2 --- Number of tumor induced --- p.131 / Chapter 6.5 --- Discussion --- p.136 / Chapter Chapter 7 --- Conclusions --- p.136 / References --- p.140

Submitted by Jean Medeiros (jeanletras@uepb.edu.br) on 2016-03-16T14:55:22Z No. of bitstreams: 1 PDF - Ivelise Fhrideraid Alves Furtado da Costa.pdf: 915520 bytes, checksum: ed4df9679f8b40eaccee586af421895a (MD5) / Approved for entry into archive by Secta BC (secta.csu.bc@uepb.edu.br) on 2016-07-22T13:12:07Z (GMT) No. of bitstreams: 1 PDF - Ivelise Fhrideraid Alves Furtado da Costa.pdf: 915520 bytes, checksum: ed4df9679f8b40eaccee586af421895a (MD5) / Made available in DSpace on 2016-07-22T13:12:20Z (GMT). No. of bitstreams: 1 PDF - Ivelise Fhrideraid Alves Furtado da Costa.pdf: 915520 bytes, checksum: ed4df9679f8b40eaccee586af421895a (MD5) Previous issue date: 2015-07-23 / Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq / AIM: To evaluate the prevalence of inactivity/lack of physical activity and sedentary behavior among adolescent students and their association with cardiovascular risk scoring Pathobiological Determinants of Atherosclerosis in Youth. METHODS: Cross-sectional study developed in the public schools of the city of Campina Grande, Paraiba, Brazil, with 576 adolescents aged 15 to 19 years. Socioeconomic variables were studied (maternal education and economic class), demographic (age, sex and race), lifestyle (physical activity, sedentary behavior and smoking), clinical (nutritional status, abdominal adiposity and blood pressure) and biochemical (cholesterol HDL and non-HDL cholesterol, fasting glucose and glycosylated hemoglobin A1c). For data collection was used validated form; anthropometric and blood collection procedures. The study was approved by the ethics committee. The results were analyzed with SPSS 22.0. Descriptive measures were used, the Pearson chi-square test for the bivariate analysis and logistic regression binomial to test the association between and cardiovascular risk predictor. 95% confidence interval was adopted. RESULTS: The mean age was 16.8 years, most were female (66.8%), not white (78.7%), belonging to classes C, D and E (69.1%). As for the sedentary and physical activity failure, the prevalences were 78.1% and 60.2%, respectively. According to the PDAY score, 10.4% of adolescents had high cardiovascular risk, 31.8% and 57.8% intermediate risk, low. There was PDAY association with sex and abdominal adiposity. CONCLUSION: It was proved the positive association between abdominal fat and males as important cardiovascular risk factors in adolescents. Considering the presence of a modifiable risk factor, preventive measures aimed at lifestyle are essential. / OBJETIVO: Avaliar a prevalência de inatividade física e do comportamento sedentário em escolares adolescentes, bem como sua associação com o risco cardiovascular mensurado pelo escore Pathobiological Determinants of Atherosclerosis in Youth (PDAY). MÉTODOS: Estudo transversal desenvolvido nas escolas públicas estaduais do município de Campina Grande, Paraíba, Brasil, com 576 adolescentes de 15 a 19 anos. Para a coleta dos dados foi utilizado formulário validado; procedimentos antropométricos e coleta sanguínea. Foram estudadas variáveis socioeconômicas (escolaridade materna e classe econômica), demográficas (idade, sexo e cor), de estilo de vida (prática de atividade física, comportamento sedentário e tabagismo), clínicas (estado nutricional, adiposidade abdominal e pressão arterial) e bioquímicas (colesterol HDL e não HDL, glicemia de jejum e hemoglobina glicosilada A1c). O estudo foi aprovado pelo comitê de ética. Os resultados foram analisados no SPSS, 22.0. Foram utilizadas medidas descritivas, o teste do qui quadrado de Pearson para a análise bivariada e a regressão logística binomial para testar a associação entre variáveis previsoras e o risco cardiovascular. Adotou-se intervalo de confiança de 95%. RESULTADOS: A idade média foi de 16,8 anos, a maioria era do sexo feminino (66,8%), não branco (78,7%), pertencentes às classes C, D e E (69,1%). Quanto ao sedentarismo e insuficiência de atividade física, as prevalências foram de 78,1% e 60,2%, respectivamente. De acordo com o escore PDAY, 10,4% dos adolescentes apresentaram alto risco cardiovascular; 31,8% risco intermediário e 57,8%, baixo. Verificou-se associação do PDAY com o sexo e com a adiposidade abdominal. CONCLUSÃO: Ficou comprovada a associação positiva entre a adiposidade abdominal e o sexo masculino como importantes fatores de risco cardiovascular em adolescentes. Considerando-se a presença de um fator de risco modificável, medidas preventivas voltadas ao estilo de vida são essenciais.

CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior / Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico / O uso de bons indicadores clÃnicos possibilita uma atribuiÃÃo mais adequada dos diagnÃsticos de enfermagem, contribuindo com a eficÃcia do plano de cuidados. A acurÃcia determina a relaÃÃo direta entre as caracterÃsticas definidoras e a presenÃa ou ausÃncia de um determinado diagnÃstico de enfermagem. A necessidade de pesquisas voltadas para a determinaÃÃo da acurÃcia diagnÃstica motivou o desenvolvimento do estudo, com o objetivo principal de analisar a acurÃcia de indicadores clÃnicos de âDesobstruÃÃo ineficaz de vias aÃreasâ (DIVA) em pacientes no pÃs-operatÃrio cardÃaco. Estudo transversal desenvolvido na unidade pÃs-operatÃria de um hospital especializado em cardiologia do municÃpio de Fortaleza-CE. Uma amostra de 98 pacientes foi selecionada consecutivamente e constituiu-se de indivÃduos de ambos os sexos, com idade acima de 18 anos e que se encontravam em pÃs-operatÃrio imediato (atà 48 horas). A coleta de dados foi realizada no perÃodo de janeiro a abril/2010, mediante a utilizaÃÃo de um formulÃrio, submetido a um teste piloto e aplicado por participantes de um projeto de pesquisa voltado para terminologias de enfermagem, apÃs treinamento e avaliaÃÃes. Foram contemplados os elementos que compÃem o diagnÃstico DIVA de acordo com a Taxonomia II da NANDA-I. ApÃs a coleta, os dados foram sintetizados no formato de casos clÃnicos e encaminhados para cinco peritas que executaram as inferÃncias diagnÃsticas. Foram utilizados os softwares Excel e PASW para organizaÃÃo e anÃlise estatÃstica dos dados. O nÃvel de significÃncia adotado foi de 5%. Verificou-se uma proporÃÃo equilibrada de homens e mulheres, predominÃncia de pessoas com baixa renda e baixa escolaridade, mÃdia de 55,89 anos de idade e vÃnculo de uniÃo estÃvel na amostra. Os diagnÃsticos mÃdicos mais prevalentes foram angina e coronariopatias, levando a uma maior incidÃncia de cirurgias reconstrutoras. A incidÃncia elevada de tabagismo mostrou-se como um elemento desfavorÃvel, repercutindo em prejuÃzos no processo de limpeza das vias aÃreas. A prevalÃncia de DIVA foi de 33,7%. Do total de 13 caracterÃsticas definidoras, somente 4 apresentaram associaÃÃes significativas com o diagnÃstico: âdispnÃiaâ, âtosse ausenteâ, âruÃdos adventÃcios respiratÃriosâ e âtosse ineficazâ, sendo as duas Ãltimas as mais acuradas. Os fatores relacionados tambÃm se mostram mais especÃficos do que sensÃveis, destacando-se: âasmaâ, âhiperplasiaâ, âalergia respiratÃriaâ e âinfecÃÃoâ, sendo os dois Ãltimos os mais acurados. Os fatores relacionados âtabagismoâ, âsecreÃÃes retidasâ e âmuco excessivoâ mostraram relaÃÃo de risco. As peculiaridades do perÃodo pÃs-operatÃrio e a alta incidÃncia de tabagismo foram apontadas como elementos que se relacionaram à incidÃncia dos indicadores clÃnicos. SugestÃes a respeito da modificaÃÃo da nomenclatura dos indicadores e da inclusÃo de um fator relacionado referente ao pÃs-operatÃrio foram contribuiÃÃes deixadas pelas peritas. Foi demonstrada a existÃncia de diferenÃas de especificidades e sensibilidades, as quais sÃo influenciadas pelas caracterÃsticas populacionais estudadas. Ressalta-se a necessidade de desenvolver estudos neste tema contemplando outras populaÃÃes. As variaÃÃes de concordÃncia entre as peritas foram atribuÃdas Ãs diferenÃas de interpretaÃÃo destas frente aos dados levantados. O estudo forneceu direÃÃo para a eficiÃncia do uso dos indicadores clÃnicos avaliados, contribuindo com o aprimoramento da acurÃcia diagnÃstica. / The use of good clinical indicators contributes to the assignment of nursing diagnoses making the care plan more effective. Accuracy determines the direct relationship between defining characteristics and the presence or absence of a specific nursing diagnose. The need for research focused on diagnosesâ accuracy motivated the development of this study, whose purpose is to examine the accuracy of clinical indicators of "Ineffective airway clearance" (IAC) in patients in post-operative period of cardiac surgeries. Cross-sectional study developed in the post-operative unit of a specialized hospital of Fortaleza-CE. A sample of 98 patients was selected consecutively and it was composed by individuals of both sexes, age above 18 years old and evaluated in the immediate post-operative (up to 48 hours). The data collection occurred within the period of January to April/2010 from a form, which had been subjected to a pilot test and applied by research project participants, focused on nursing terminologies, after training and evaluations. The components of the nursing diagnose IAC were evaluated according to the NANDA-I Taxonomy. Clinical cases were formulated after the data collection and five specialists performed the diagnostic inference. For the organization and statistical analysis of data collected, the software Excel and PASW were used. The level of significance adopted in the study was 5%. The proportion of men and women was equal in the sample, with predominance of people with low income and low scholarship, with average of 55.89 years old and living with a partner. The clinical diagnosis angina and coronary diseases were more prevalent, increasing the incidence of reconstructive surgeries in the sample. The high incidence of smoking was showed as a favorable factor for dysfunction in the process of airway clearance. The prevalence of ICA was 33.7%. Four of thirteen defining characteristics have significant associations with the studied diagnosis: "dyspnea", "absence of cough", "adventitious breath sounds" and "ineffective cough", and the last two were accurate. Some of related factors were more specific that sensitive: "asthma", "hyperplasia", "allergic airways" and "infection", and the last two were the most accurate. The related factors: "smoking", "retained secretions" and "excessive mucus" increased the risk for IAC. Peculiarities of post-operative period and the high incidence of smoking were identified as elements linked to the incidence of clinical indicators. Contributions left by specialists were suggestions concerning the modification of the nomenclature and the inclusion of a related factor for post-operative period. The study demonstrated the existence of difference in the specificities and sensitivities, which are influenced by population characteristics. The need of further studies development in other contexts was emphasized. Changes in the trial of the specialists were attributed to differences in their interpretations. The study gave us a direction towards the diagnostic efficiency for some clinical indicators contributing to improve the accuracy of these elements.

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No. of bitstreams: 2 Dissertação Fernanda Hilgenberg Junho 2013.pdf: 729856 bytes, checksum: 42efd86e7217861afe40c248e3bf456f (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2013-05-29 / Modifications in contemporary lifestyles reflect negatively on the individuals’ health status and are associated with the incidence of cardiovascular risk factors (CVRF), and hence with the genesis of cardiovascular disease (CVD). Currently, 31.3% of deaths in Brazil occur in consequence of CVD. It is observed that CVRF have been affecting the younger population, even the Brazilian military. Therefore, the aim of this study was to determine the prevalence of some CVRF in cadets from the Brazilian Air Force Academy (AFA). It was a cross-sectional observational study that evaluated 166 cadets from the 1st to the 4th year of the AFA. Data collection was performed at the AFA’s Clinic of Nutrition from the Health Subdivision , with measures of anthropometric data: weight, height, body mass index, waist circumference and skinfold thickness. Blood was collected for lipid profile and serum glucose evaluation. Blood pressure was measured at rest. Three-day food records were collected and analyzed using the software Avanutri®. Lifestyle was assessed with a questionnaire which included physical activity and smoking habit data. The Pearson Chi-Square or Fisher's exact tests were used to assess the associations between CVRF, gender and the year of entrance at the AFA. The food consumption data were adjusted to the energy by the residual method. The significance level of 5% was adopted as standard. The study was submitted to the Ethics Committee of Federal University of Goias and approved under Protocol n°. 189/12. The sample was composed of 147 men and 19 women, mean (± SD) age of 21.5 ± 1.2 and 21.6 ± 0.9 years, respectively. It was verified that 29.7% of men and 16.7% of women were overweight or obese. The prevalence of hypertension among men was 15.2%. The lipid profile revealed that 50.7% of the cadets had hypercholesterolemia, 24.3% had elevated LDL-c and 11.2%, low HDL-c. There was a significant association between the time spent at AFA and low HDL-c. The prevalence of low HDL-c was statistically higher among the cadets from the 1st and 2nd years. Food consumption data showed that 58.7% of men and 50% of women had an intake above the daily requirement. There was a high prevalence of saturated fats (87.2%) and cholesterol (42.7%) intake in both genders. No cadet reached the recommendations for monounsaturated and polyunsaturated fat intake and the inadequate intake of dietary fiber was reported in 92.7% of them. It was verified that the young military personnel are exposed to CVRF in a similar manner to young civilians. These results are relevant in order to create and install multidisciplinary approaches aiming at reducing the risk of CVD in the early stages of adulthood, thereby ensuring a better quality of life and reduction of cardiovascular health problems in the long term of the future officers of Brazilian Air Force. / As mudanças no estilo de vida contemporâneo refletem negativamente no estado de saúde dos indivíduos e estão associadas à incidência dos fatores de risco cardiovascular (FRCV) e, consequentemente, na gênese das doenças cardiovasculares (DCV). Atualmente, 31,3% das mortes no Brasil ocorrem em decorrências das DCV. Verifica-se que os FRCV vêm acometendo a população mais jovem, até mesmo os militares brasileiros. O objetivo deste estudo foi determinar a prevalência de alguns FRCV em cadetes da Academia da Força Aérea Brasileira (AFA). Tratou-se de um estudo observacional do tipo transversal que avaliou 166 cadetes do 1ª ao 4ª ano da AFA. A coleta dos dados foi realizada no Ambulatório de Nutrição da Subdivisão de Saúde da AFA, onde foram aferidos dados antropométricos: peso, estatura, índice de massa corporal, circunferência da cintura e dobras cutâneas. Houve coleta de sangue para avaliação do perfil lipídico e glicemia. A pressão arterial foi aferida em repouso. Registros alimentares de três dias foram coletados e analisados com o software Avanutri®. O estilo de vida foi avaliado por meio de questionário sobre atividade física e tabagismo. Os testes de Qui-Quadrado de Pearson ou Teste Exato de Fisher foram empregados para avaliar a associação entre os FRCV, o gênero e o ano de formação dos cadetes na AFA. Os dados do consumo alimentar foram ajustados ao valor energético pelo método residual O nível de significância de 5% foi adotado como padrão. A pesquisa foi submetida ao Comitê de Ética em Pesquisa da Universidade Federal de Goiás e aprovada sob Protocolo nº 189/12. Participaram da pesquisa 147 homens e 19 mulheres, com média (±DP) de idade de 21,5 ± 1,2 e 21,6 ± 0,9 anos, respectivamente. Verificou-se que 29,7% dos cadetes homens e 16,7% das mulheres apresentaram sobrepeso ou obesidade. A prevalência de hipertensão arterial sistêmica (HAS) entre os homens foi de 15,2%. Quanto ao perfil lipídico, foi constatado que 50,7% dos cadetes apresentaram hipercolesterolemia, 24,3% apresentaram valores elevados de LDL-c e 11,2%, HDL-c baixa. Verificou-se associação significativa entre o tempo de permanência na AFA e HDL-c baixa. A prevalência de HDL-c baixa foi estatisticamente maior entre os cadetes dos 1º e 2º anos. Dados do consumo alimentar mostraram que 58,7% dos homens e 50% das mulheres apresentaram ingestão energética superior à necessidade diária. Houve consumo elevado de gorduras saturadas (87,2%) e colesterol (42,7%) entre os dois gêneros. Nenhum cadete atingiu as recomendações para ingestão de gorduras mono e poli-insaturadas. A ingestão inadequada de fibras alimentares foi verificada em 92,7% dos cadetes. Verificou-se que os jovens militares estão expostos a alguns FRCV de maneira semelhante aos jovens civis. Estes resultados são relevantes no sentido de criação e instalação de abordagens multiprofissionais voltadas para redução do risco das DCV ainda nas fases iniciais da vida adulta, assegurando, dessa forma, melhor qualidade de vida e diminuição de agravos à saúde cardiovascular em longo prazo dos futuros oficiais da Força Aérea Brasileira.

Objetivo Avaliar, em indivíduos com diabetes (DM), a resposta de glicose e triglicerídeos duas horas após a ingestão de uma carga alimentar (CA) e sua associação com características clínicas e a presença de doenças crônicas. Metodologia Foram incluídos 915 indivíduos com DM, participantes da linha de base do estudo ELSA-Brasil. Coleta de sangue foi realizada em jejum e duas horas após o consumo da CA, contendo 455 kcal; 14 g de gordura saturada e 47 g de carboidratos. Regressão linear foi utilizada para investigar preditores dos níveis de excursão (diferença entre níveis pós-carga e de jejum) de glicemia e trigliceridemia (variáveis dependentes). Regressão logística foi realizada para descrever a associação da excursão de glicemia e trigliceridemia (variáveis independentes) e a presença de complicações do DM (doença coronariana, infarto, angina, acidente vascular cerebral, ou insuficiência cardíaca). Resultados A mediana da glicemia de jejum foi de 150 (123–198) mg/dL e da excursão de glicose foi 45 (16–79) mg/dL, enquanto que a trigliceridemia de jejum foi de 140 (103–199) mg/dL e a excursão de triglicerídeos foi de 26 (11–45) mg/dL. Maiores excursões de glicemia foram associadas com duração do DM (incremento de 5,7 mg/dL, IC95% 3,7–7,6, a cada 5 anos de doença), uso de insulina (58,5 mg/dL, IC95% 45,43–71,55), outro medicamento para DM (13,6 mg/dL, IC95% 2,5–24,8), idade (4,1 mg/dL, IC95% 0,43–7,69, a cada 10 anos), nível de glicose basal (5,2 mg/dL, IC95% 1,0–4,1, a cada 25 mg/dL); o índice de massa corporal associou-se a menor excursão (-6,8 mg/dL, IC95% -9,7 a -3,85, a cada 5 kg/m²). Maior excursão de trigliceridemia esteve associada com glicemia em jejum (2,5 mg/dL, IC95% 1,64–3,38, a cada 25 mg/dL), e menor excursão associada com triglicerídeos de jejum (-2,97 mg/dL, IC95% -3,24 – -2,69, a cada 25 mg/dL). Conclusão A resposta pós-prandial esteve associada ao tempo de doença, à necessidade de insulina ou outro medicamento para DM, ao índice de massa corporal, além da idade e níveis basais de glicose e triglicerídeos. As excursões de glicose e triglicerídeos estiveram associadas a presença de comorbidades potencialmente tidas como complicações do DM. / Objective We aimed to assess, in individuals with diabetes (DM), the excursions of glucose and triglyceride levels two hours after consumption of a food load (FL) and their association with clinical characteristics and the presence of chronic diseases. Design and Methods We included 915 subjects with DM, participants of in the ELSA-Brazil cohort. Blood sampling was performed at fasting and two hours after consumption of a 455 kcal, 14 g saturated fat and 47 g carbohydrate FL. Linear regression was used to investigate predictors of levels of excursion (difference between post-load and fasting levels) of glucose and triglycerides (dependent variables). Logistic regression was performed to describe the association of glucose excursion and triglycerides excursion (independent variables) and the presence of DM complications (coronary heart disease, myocardial infarction, angina pectoris, stroke, or heart failure). Results The median fasting glucose was 150 (123-198) mg/dL and glucose excursion was 45 (16-79) mg/dL, whereas fasting triglycerides was 140 (103-199) mg/dL and triglycerides excursion was 26 (11-45) mg/dL. Increase of glucose excursion were associated with DM duration (increase of 5.7 mg/dL, 95% CI 3.7 to 7.6, each 5 years of disease), insulin use (58.5 mg/dL, 95% CI 45.43 to 71.55), use of another drug for DM (13.6 mg/dL , 95% CI 2.5 to 24.8), age (4.1 mg/dL, 95% CI 0.43 to 7.69, each 10 years), fasting glucose (5.2 mg/dL, 95% CI 1.0 to 4.1, each 25 mg/dL) and body mass index (-6.8 mg/dL, 95% CI -9.7 to -3.85, each 5 kg/m²). The triglycerides excursion was associated with fasting glucose (2.5 mg/dL, 95% CI 1.64 to 3.38, each 25 mg/dL) and fasting triglycerides (-2.97 mg/dL, 95% CI -3.24 to -2.69, each 25 mg/dL). In logistic regression models adjusting for gender, age, fasting glucose, duration of diabetes, use of insulin and/or other drug for DM, the excursion of glucose was marginally associated with the presence of any complication of diabetes and coronary heart disease. Conclusion Greater glycemic postprandial response was positively associated with indicators of less pancreatic reserve and negatively associated with obesity, while and the size of the response in triglycerides presented only minimal associations. Associations of excursion size with diabetes complications were present.

Introdução: no contexto das doenças crônicas não transmissíveis (DCNT), vários estudos associam a presença de determinados polimorfismos de nucleotídeo único (SNP) ao risco de desfechos metabólicos, como a obesidade e a dislipidemia. Objetivo: avaliar a presença de SNP associados à adiposidade corporal e ao metabolismo lipídico sobre o índice de massa corporal (IMC), o consumo alimentar, o perfil lipídico e a concentração plasmática de biomarcadores inflamatórios em indivíduos adultos participantes do estudo de base populacional (ISA-Capital). Métodos: 244 indivíduos adultos de ambos os gêneros (idade entre 20-59 anos) participaram do estudo, no qual foram realizadas as avaliações antropométricas e do consumo alimentar por meio do questionário de 24 horas (R24h) e a coleta de sangue para avaliação da concentração de biomarcadores inflamatórios. O índice de qualidade da dieta revisado (IQDR) foi utilizado no estudo. Foi realizada a genotipagem de oito genes e 13 SNP (FTO rs9939609, rs8050136, rs9930506; LDLR rs688, rs5925; APOB rs693, rs1367117, APOA5 rs662799; LIPC rs2070895, rs1800588; FADS1 rs174546; MYRF rs174537 e ELOVL2 rs953413) pelo sistema TaqMan Open Array. A partir dos resultados da genotipagem, foi elaborado um escore de risco genético (ERG). Resultados: foi verificada associação negativa entre o consumo de vegetais totais (P=0,004) e vegetais verdes-escuros e alaranjados e leguminosas (P=0,002) e leite e derivados (P=0,009) com o IMC. O consumo de cereais totais (P=0,029) e de carboidratos totais (P=0,011) mostrou interação negativa para o ERG, enquanto o consumo de carnes, ovos e leguminosas teve interação positiva (P=0,028) ao influenciar o IMC. As concentrações plasmáticas de HDL-c tiveram associação negativa (P=0,026) com o IQDR e associação positiva (P=0,007) com o componente Gord_AA (valor energético proveniente da gordura sólida, álcool e açúcar de adição). Foi encontrada interação significativa entre o consumo de óleos (lipídios insaturados) (P=0,019) e de Gord_AA (P<0,001). Concentrações plasmáticas de HDL-c e de LDL-c são significativamente menores nos carreadores do alelo variante T para os SNP que correspondem às atividades das enzimas dessaturases (FADS1 e MYRF). As concentrações do ácido oleico foram maiores nos indivíduos com genótipo CT/TT no gene da FADS1 e AG/GG no gene da ELOVL2 em relação aos genótipos selvagens. Apenas os carreadores do alelo T tanto em FADS1 quanto em MYRF tiveram concentrações de ácido linoleico e linolênico superiores em relação aos genótipos selvagens. Por outro lado, as concentrações de ácido araquidônico, de ácido docosapentaenoico (DPA), de ácidos graxos saturados e de poli-insaturados totais foram menores nos indivíduos carreadores dos alelos variantes para os três polimorfismos avaliados. O conteúdo de ácido eicosapentaenoico (EPA) foi menor nos carreadores do alelo T dos genes FADS1 e MYRF, enquanto o conteúdo de ácido esteárico foi menor apenas nos carreadores do alelo G do gene ELOVL2, sendo que nestes indivíduos as concentrações plasmáticas do conteúdo total de ácidos monoinsaturados foram significativamente maiores quando comparados ao genótipo selvagem (AA). Observou-se também que a atividade estimada da enzima estearoil CoA dessaturase (SDC_18) é maior nos genótipos CT/TT da FADS1 e da ELOVL2. Contudo, a estimativa da atividade da enzima delta-5 dessaturase (D5D) foi estatisticamente menor na presença do alelo polimórfico para os três SNP estudados (FADS1 CT/TT; MYRF GT/TT; ELOVL2 AG/GG). Apenas para os carreadores do alelo T da FADS1 (CT/TT), a estimativa da atividade da enzima delta-6 dessaturase (D6D) foi estatisticamente menor em relação ao genótipo selvagem CC. Conclusões: a presença dos SNP estudados na população de São Paulo mostraram associações em relação ao aumento do risco para adiposidade corporal e dislipidemias, podendo também apresentar associações com a qualidade da dieta dos participantes. Nesse sentido, a aplicação do IQDR junto com o ERG pode ser uma ferramenta útil na identificação de associações entre gene-nutriente e o impacto nas doenças metabólicas. / Introduction: excess weight and changes in lipid profile may be associated with environmental factors, such as diet quality, and non-modifiable factors, such as genetic inheritance. In the context of chronic noncommunicable diseases (NCDs), several studies associate the presence of certain single nucleotide polymorphisms (SNP) to the risk of metabolic outcomes, such as obesity and dyslipidemia. Objective: to evaluate the presence of SNP associated with body fat and lipid metabolism on body mass index (BMI), dietary intake, lipid profile and plasma concentration of inflammatory biomarkers in adult individuals participating in the population-based study (ISA-Capital). Methods: 244 adult subjects of both genders (ages 20-59 years) participated in the study, in which the anthropometric traits were evaluated, and food consumption evaluations were performed using the 24- hour questionnaire (R24h) and blood collection for evaluation of concentration of inflammatory biomarkers. The Brazilian healthy eating index revised (BHEIR) was used in the study. Genotyping of eight genes and 13 SNP (FTO rs9939609, rs8050136, rs9930506; LDLR rs688, rs5925; APOB rs693, rs1367117, APOA5 rs662799; LIPC rs2070895, rs1800588; FADS1 rs174546; MYRF rs174537 and ELOVL2 rs953413) were performed by the TaqMan Open Array system. From the results of the genotyping, a genetic risk score (GRS) was elaborated. Results: there was a negative association between the consumption of total vegetables (p = 0.004) and dark green and orange vegetables and legumes (p = 0.002), milk and dairy (p=0.009) with BMI. Total cereal consumption (p = 0.029) and total carbohydrates (p = 0.011) showed negative interaction for GRS (categories 3 to 5), while meat, egg and legume consumption had a positive interaction (p = 0.028) influence BMI. Of the BHEIR components, plasma HDL-c concentrations were negatively associated (p = 0.026) with the BHEIR and positive association (p = 0.007) with the SoFAAS component (energy value from solid fat, alcohol and addition sugar). Significant interaction was observed between the consumption of oils (unsaturated lipids) (p = 0.019) and SoFAAS (p <0.001). About the enzymes associated with biosynthesis of omega 3 and polyunsaturated fatty acids 6, plasma HDL-c and LDL-c plasma concentrations are significantly lower in carriers of the T variant allele for SNP that correspond to the activities of desaturases (FADS1 and MYRF). Oleic acid concentrations were statistically higher in individuals with CT / TT genotypes in the FADS1 and AG / GG gene in the ELOVL2 gene in relation to wild genotypes. In addition, only the T allele carriers in both FADS1 and MYRF had higher concentrations of linoleic and linolenic acid than wild genotypes. The concentrations of arachidonic acid, docosapentaenoic acid (DPA), saturated fatty acids and total polyunsaturated fatty acids were lower in the carriers of the variant alleles for the three evaluated polymorphisms. The eicosapentaenoic acid (EPA) content was lower in the T allele carriers of the FADS1 and MYRF genes, while the stearic acid content was lower only in the G allele carriers of the ELOVL2 gene, where in these individuals the plasma concentrations of the total content of monounsaturated acids were significantly higher when compared to the wild-type (AA) genotype. It was also observed that the estimated activity of the stearoyl CoA desaturase enzyme (SDC_18) is higher in the CT / TT genotypes of FADS1 and ELOVL2. However, the estimate of the activity of the enzyme delta-5 desaturase (D5D) was statistically lower in the presence of the polymorphic allele for the three SNP studied (FADS1 CT/ TT; MYRF GT / TT; ELOVL2 AG / GG). Only for the FADS1 (CT / TT) allele carriers, the estimate of the activity of the enzyme delta-6 desaturase (D6D) was statistically lower than the wild-type CC genotype. Conclusions: the presence of SNP studied in the population of São Paulo showed associations in relation to the increased risk for body fatness and dyslipidemia and may also present associations with the quality of the participants\' diet. In this sense, the application of BHEIR together with GRS may be a useful tool in the identification of genenutrient associations and the impact on metabolic diseases.