The budding yeast Saccharomyces cerevisiae has been an invaluable model organism in contributing to the current understanding of cellular biology, owing mainly to its highly tractable genetic system and the completion of its genome sequencing in 1996. Indeed, these bolstered the development of novel methods that have provided great insights into genetic and protein networks in human cells. With the large collection of datasets, S. cerevisiae also became an ideal platform for investigating the mechanism of action of novel compounds. The first part of my thesis uses a validated chemogenomic assay to investigate the mechanism of action of structurally related novel DNA-damaging agents, delineating valuable structure-activity relationship in the process. The second part describes the development of a method that uses drug-induced wild-type growth dynamic to characterize novel compounds, which, in combination with the chemogenomic assay, may complement existing high throughput screening experiments to improve the current drug development process.

The budding yeast Saccharomyces cerevisiae has been an invaluable model organism in contributing to the current understanding of cellular biology, owing mainly to its highly tractable genetic system and the completion of its genome sequencing in 1996. Indeed, these bolstered the development of novel methods that have provided great insights into genetic and protein networks in human cells. With the large collection of datasets, S. cerevisiae also became an ideal platform for investigating the mechanism of action of novel compounds. The first part of my thesis uses a validated chemogenomic assay to investigate the mechanism of action of structurally related novel DNA-damaging agents, delineating valuable structure-activity relationship in the process. The second part describes the development of a method that uses drug-induced wild-type growth dynamic to characterize novel compounds, which, in combination with the chemogenomic assay, may complement existing high throughput screening experiments to improve the current drug development process.

對偏差行為的解釋有多種理論，不過以後天的角度詮釋偏差行為，則社會控制理論、自我控制理論是最有力的解釋理論。本研究亦欲圖驗證此兩種理論在多變量潛在成長模型的效用。因此，研究者採用臺灣教育長期追蹤資料庫之資料，以自我控制信念、親子關係、同儕關係、學校依附感、教育抱負、學業成就預測偏差行為之變化。此外，並探究性別對潛在成長模型之影響。茲將研究成果陳述如下。 1、偏差行為隨著年級逐漸增加，日益增加，變異數亦逐漸擴大。 2、整體多變量潛在成長模型中，整體模式適配度良好。 3、自變項對偏差行為截距、斜率解釋量分別為.19、.32，顯示模式的解釋量仍有改善空間，其中對截距之預測達顯著者，分別為同儕關係截距、學校依附感截距、學業成就截距、親子關係截距。對斜率之預測力達顯著者，分別為學校依附感斜率、學校依附感截距、同儕關係斜率、同儕關係截距、教育抱負截距。 4、運用多群組分析，發現男女生並無測量不變性。 5、性別對偏差行為有重要影響。 6、預測女生的斜率主要考量其學校依附感和同儕關係，但預測男生偏差行為的斜率除了與學校、同儕的關係外，還要考量其教育抱負。 最後，根據上述的結論，研究者分別提出實務、研究方法、未來偏差行為研究之建議，以作為參考。 / The cause of deviation behavior is explained by many theories. However, social control theory and self control theory are the most famous and important theories. Research would like to confirm the theories which are applied in multivariable latent growth curve model. Therefore, TEPS data are analyzed to investigate the model, and the results are as follows: (1)Deviation behavior gradually increases with time and variety of it also rises. (2)The fit of model is good. (3)The intercept is explained 19% by independent variables and the slope is explained 32%. In addition, it is significant for the intercept of the relation of peer group, attachment feeling of school, parental relation and academic achievement in the regression which is employed to anticipate the intercept. It is significant that the intercept of the relation of peer group, attachment feeling of school, and educational ambition and the slope of peer group, and attachment feeling of school can anticipate slope of deviation behavior effectively. (4)Employing multi-group analysis, there exist gender differences in the model. (5)Sex has influence on deviation behavior. (6)For girls, the slope of deviation behavior is anticipated by social relations, but for boys, besides the peer relationship, it is also included the educational ambition. According the results, some suggestions are proposed for future researches and the administration authority.

Made available in DSpace on 2014-06-11T19:26:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-15Bitstream added on 2014-06-13T20:54:07Z : No. of bitstreams: 1 gaviolli_vrn_me_jabo.pdf: 597637 bytes, checksum: 970dfc2e9d73c9379c7a724eab7ac345 (MD5) / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / Os objetivos deste trabalho foram identificar as funções matemáticas que melhor se ajustam para descrever o crescimento de fêmeas da raça Canchim e do grupo genético MA (filhos de touros da raça Charolesa e vacas ½ Canchim + ½ Nelore), e estimar a herdabilidade dos parâmetros A e k da curva que melhor se ajustou aos dados e a correlação genética desses com a idade (IPP) e o peso (PPP) ao primeiro parto e idade (ISP) e peso (PSP) ao segundo parto. As funções não lineares Brody, Richards, Von Bertalanffy e duas alternativas de Gompertz e de Logístico foram ajustadas pelo método de Gauss Newton e procedimento NLIN do SAS, a dados peso-idade de 1.923 bovinos da raça Canchim e MA, nascidos de 1972 a 2006, com pesagens no mínimo até os 37 meses de idade e no máximo até os 100 meses de idade e com pelo menos sete pesagens. A comparação entre os modelos foi realizada com base na interpretação biológica dos parâmetros e nos avaliadores de qualidade de ajuste. A estimação dos parâmetros genéticos foi feita pelo método da máxima verossimilhança restrita, utilizando análises uni e bicaracterísticas com modelos que incluíram o efeito fixo de grupo de contemporâneos e o efeito aleatório aditivo direto. Os modelos Brody e Von Bertalanffy ajustaram aos dados peso-idade, enquanto que os demais não convergiram, sendo que o modelo Brody foi escolhido para a obtenção dos parâmetros A e k de cada animal. As estimativas de herdabilidade obtidas foram 0,32 ± 0,05; 0,12 ± 0,04; 0,12 ± 0,04; 0,43 ± 0,06; 0,19 ± 0,06 e 0,44 ± 0,06, para A, k, IPP, PPP, ISP e PSP, respectivamente. Estes resultados sugerem que é possível, mas difícil obter mudanças na curva de crescimento dos animais pela seleção. As estimativas de correlação genética dos parâmetros A e k com as idades e os pesos aos partos sugerem que a seleção para modificar A deve provocar mudanças no... / The objectives in this study were to identify the mathematical function that best fits the growth of Canchim and MA (offspring of Charolais bulls and ½ Canchim + ½ Nelore cows) females, and to estimate the heritability of parameters A and k of the function that best fitted the data and the genetic correlations of these parameters with age (IPP) and weight (PPP) at first calving and age (ISP) and weight (PSP) at second calving. Brody, Richards, Von Bertalanffy and two alternatives of Gompertz and of Logistic non-linear models were fitted by Gauss Newton method and NLIN procedure of SAS. Weight-age data of 1,923 females born from 1972 to 2006, with weighing at least at 37 months of age and at most at 100 months of age, and with at least seven weighing were used. The comparison between the models was based on the biological interpretation of parameters and measures of quality of adjustment. The genetic parameters were estimated by the restricted maximum likelihood method using one and two-trait analyses with animal models that included the fixed effect of contemporary group and the random additive direct effect. The Brody and the Von Bertalanffy models adjusted the weight-age data well, while the others did not converge, and the Brody function was chosen to obtain the parameters A and k of each animal. The heritability estimates were 0.32 ± 0.05, 0.12 ± 0.04, 0.12 ± 0.04, 0.43 ± 0.06, 0.19 ± 0.06 and 0.44 ± 0.06 for A, k, IPP, PPP, ISP and PSP were, respectively. These values suggest that it is possible, but difficult to obtain changes in the pattern of the growth curve of the animals by selection. Estimates of genetic correlation of parameters A and k with the other traits suggest that selection to change A should cause changes in the same direction in PPI, PPP, ISP and PSP, and that changes in k, if they occur, should also be followed by changes in the other traits, but in the opposite direction

The objective of this study outline a diagnosis of dairy farming in the municipality of Nossa Senhora da Gloria, State of Sergipe, addressing productive and reproductive aspects, and test mathematical models for their suitability to describe the curves of growth and lactation in cattle compounds by crossbred animals Taureans x Zebu cattle. Article 1: Technical evaluation of milk production systems in the region of Nossa Senhora da Gloria, State of Sergipe. Eight producers were selected, which were grouped according to the following scale daily milk yield (kg/day) Group 1 (G1) . 100 kg/day, group 2 (G2): > 100 kg / day . 500, Group 3 (G3):> 500 kg / day. Productivity per cow per year differed between groups (p <0.05) with values of 2.226,06, 4.428,50 and 6063.84 kg / cow / year for G1, G2 and G3, respectively. In land productivity G1 (1.801,63 kg / ha / year) did not differ from G2 (1.562,26 kg/ha/year) and G3 (3.798,08 kg/ha/ year), however the latter two differed other (p <0,05). The reproductive indices obtained for G1, G2 and G3 were: calving interval of 14,59, 12,96 and 13,14 months; service period 169,89, 121,89 and 125,95 days and rates of pregnant 14,87, 28,01 and 17,99%. The G2 got better reproductive rates (P <0,05). Given the above, it is concluded that the groups of producers with production less than 100 kg of milk/day and between 101 and 500 kg milk/day are technically feasible for the region studied. Article 2: Comparison of nonlinear models to describe the growth of females Taurino x Zebu crossbred dairy cattle in Nossa Senhora da Gloria, State of Sergipe. We used 537 records of weighings made at intervals of 30 days during the period from 2010 to 2012. The mathematical models used were: Brody (BD), Von Bertalanffy (VB), Logistics (LG) and Gompertz (GP). The weights and asymptotic growth rates instant (TCI) were respectively: BD, 1.982 kg and 0,451 to 0,555 kg/month, for VB, 550,50 kg and 0,535 to 12,04 kg/month, LG, 405,20 kg and 0,0021 to 0,180 kg/month, GP, 479,70 kg and 0,259 to 0,623 kg/month. The VB model fitted well the growth curve, however showed greater deviation in the rate curve TCI compared to the observed data. The GP model showed better adaptation to growth data crossbred females with genetic variation between groups of Taurino x Zebu crosses in semi-extensive system. Article 3: Shape of lactation curve in Taurino x Zebu crossbred females in the semi-arid region of Sergipe. 1496 records were used for milk production performed every 30 days during the period from 2011 to 2012. The adjustment was made for the mean curve, making the use of four mathematical models: Nelder, 1966 (ND), Wood, 1967 (WD), Bianchini Sobrinho, 1984 (BS) and Wilmink, 1987 (WK). The average values of Ra2 were <0,82. All curves showed typical patterns. The other functions in the graph showed similar distribution of waste, however only the function ND was able to estimate the components of the lactation curve effectively. / Objetivou-se com esse estudo tracar um diagnostico da atividade leiteira no municipio de Nossa Senhora da Gloria, Estado de Sergipe, abordando aspectos produtivos e reprodutivos, e testar modelos matematicos quanto a sua adequacao para descrever as curvas de crescimento e de lactacao de rebanhos compostos por animais mesticos de Taurinos x Zebus. Artigo 1: Avaliacao tecnica de sistemas de producao de leite na regiao de Nossa Senhora da Gloria, Estado de Sergipe. Foram selecionados oito produtores, os quais foram agrupados de acordo com a seguinte escala de producao de leite diaria (kg/dia): Grupo 1 (G1): . 100 kg/dia; Grupo 2 (G2): > 100 kg/dia e . 500; Grupo 3 (G3): > 500 kg/dia. A produtividade por vaca por ano diferiu entre os grupos (p<0,05) com valores de 2.226,06, 4.428,50 e 6.063,84 kg de leite/vaca/ano para G1, G2 e G3, respectivamente. Na produtividade da terra o G1 (1.801,63 kg/ha/ano) nao diferiu de G2 (1.562,26 kg/ha/ano) e G3(3.798,08 kg/ha/ano), no entanto estes dois ultimos diferiram entre si (p<0,05). Os indices reprodutivos obtidos para G1, G2 e G3 foram respectivamente: intervalo de partos de 14,59, 12,96 e 13,14 meses; periodo servico de 169,89, 121,89 e 125,95 dias e taxas de prenhes de 14,87, 28,01 e 17,99%. O G2 obteve melhores indices reprodutivos (P<0,05). Diante do exposto, conclui-se que os grupos de produtores com producoes menores que 100 kg de leite/dia e entre 101 e 500 kg de leite/dia sao tecnicamente viaveis para a regiao estudada. Artigo 2: Comparacao de modelos nao-lineares para descrever o crescimento de femeas mesticas Taurino x Zebu na bacia leiteira de Nossa Senhora da Gloria, Estado de Sergipe. Foram utilizados 537 registros de pesagens realizadas em intervalos de 30 dias durante o periodo de 2010 a 2012. Os modelos matematicos utilizados foram: Brody (BD), Von Bertalanffy (VB), Logistico (LG) e Gompertz (GP). Os pesos assintoticos e as taxas de crescimento instantaneas (TCI) foram respectivamente: para BD, 1.982 kg e 0,451-0,555 kg/mes; para VB, 550,50 kg e 0,535-12,04 kg/mes; LG, 405,20 kg e 0,0021-0,180 kg/mes; GP, 479,70 kg e 0,259-0,623 kg/mes. O modelo VB ajustou-se bem a curva de crescimento, no entanto apresentou maior desvio na curva da taxa TCI em relacao aos dados observados. O modelo de GP apresentou melhor adaptacao aos dados de crescimento de femeas mesticas com variacao de grupos geneticos entre cruzamentos de Taurino x Zebu em sistema semi-extensivo. Artigo 3: Forma da curva de lactacao em femeas mesticas Taurino x Zebu no Semi-arido de Sergipe. Foram utilizados 1496 registros de producao de leite realizados em intervalos de 30 dias durante o periodo de 2011 a 2012. O ajuste foi feito para a curva media, fazendo-se o uso de quatro modelos matematicos: Nelder, 1966 (ND), Wood, 1967 (WD), Bianchini Sobrinho, 1984 (BS) e Wilmink, 1987 (WK). Os valores medios de Ra2 foram < 0,82. Todas as curvas apresentaram padroes tipicos. As demais funcoes apresentaram comportamento semelhante no grafico de distribuicao dos residuos, no entanto somente a funcao ND foi capaz de estimar os componentes da curva de lactacao de forma eficaz.

Made available in DSpace on 2017-07-10T18:13:12Z (GMT). No. of bitstreams: 1 Daiany Crystina Macagnan.pdf: 533832 bytes, checksum: 1ef92ef1a169ce21091effcd15916599 (MD5) Previous issue date: 2011-07-25 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The wastewater is generated daily in all the activities that need water in their process, whether health activities for residential and commercial or manufacturing processes of enterprises. This study evaluated the efficiency of the microalgae Scenedesmus in nitrogen and phosphorus removing from brewery wastewater. Two experiments were conducted at different times in three replicates of each one packaged in boxes of fiberglass 100L. Each treatment was made for a completely randomized design with three different concentrations of wastewater. The collect of wastewater was made at different times. The medium was constituted of 80L of wastewater and five liters of inoculated culture of microalgae Scenedesmus sp. We evaluated the growth curve, phosphate and nitrogen compounds removal, the correlation between the removal of compounds with algal growth, yield and protein biomass. Higher algal density was observed in the treatment 6 (T6) medium with 776 x 104 cells / mL and all treatments had high coefficients of determination (R2) ranging from 0.87 to 0.99 in T4 at T6. In the experiment 1 the removal of the compounds in the treatments occurred in 17 days. In experiment 2 the nitrate removed in 17 days in all treatments and orthophosphate and phosphorus removal occurred between nine to 24 days. Generally, the correlations ranged from moderate to strong, with the exception of total phosphorus in T4 which showed a weak correlation (-0.08).The biomass and crude protein in experiment 1 ranged from 0.15 to 0.19 g / L and 19 to 27% respectively, while those in experiment 2 ranged from 0.12 to 0.19 g / L and 34 to 46% protein. It is concluded that biological treatment from microalgae is able to reduce the nitrate, phosphorus and orthophosphate present in the brewery wastewater, producing biomass with high protein values. / As águas residuárias são geradas diariamente em todas as atividades que necessitam de água em seu processo, sejam elas atividades sanitárias residenciais e comerciais ou pelos processos produtivos das empresas. Neste trabalho avaliou-se a eficiência do gênero de microalgas Scenedesmus na remoção de compostos nitrogenados e fosfatados de efluente de cervejaria. Foram realizados dois experimentos em períodos diferentes e cada um tratou-se de um delineamento inteiramente casualizado com três concentrações de efluente de cervejaria oriundos de coletas em horários diferentes e três repetições de cada tratamento acondicionados em caixas de fibra de vidro de 100L. Em cada unidade experimental foram adicionados 80L de efluente e inoculados cinco litros de cultura de microalga Scenedesmus sp. Avaliaram-se a curva de crescimento, a remoção dos compostos fosfatados e nitrogenados, a correlação entre a remoção dos compostos com o crescimento algal, o rendimento e a proteína da biomassa. A maior densidade algal observada foi no tratamento 6 (T6) com média 776 x 104 cél./mL e todos os tratamentos apresentaram altos coeficientes de determinação (R2) variando de 0,87 em T4 a 0,99 em T6. A remoção dos compostos nos tratamentos do experimento 1 ocorreram em 17 dias. No experimento 2 houve remoção do nitrato em 17 dias em todos os tratamentos e as remoções do ortofosfato e do fósforo variaram de nove a 24 dias. De modo geral as correlações variaram de moderada a forte, com exceção do fósforo total em T4 que mostrou correlação fraca (-0,08). Os rendimentos da biomassa e proteína bruta no experimento 1 variaram de 0,15 a 0,19g/L e de 19 a 27% de proteína, enquanto no experimento 2 esses valores variaram de 0,12 a 0,19g/L e de 34 a 46% de proteína. Conclui-se que esse tratamento biológico a partir de microalgas é capaz de reduzir os teores de nitrato, fósforo e ortofosfato presentes no efluente de cervejaria, gerando biomassa com altos valores protéicos.

The need for the identification and appropriate development of talent in organisations has led to a renewed interest in the accuracy of tools used in this context. The objectives of the study were to: (1) determine whether there is a significant difference in the growth in theoretical capability as predicted by Career Path Appreciation (CPA) 1 and CPA 2 among the sample population, (2) determine whether there is a significant difference in Mode as predicted by CPA 1 and CPA 2 among the sample population, and (3) formulate recommendations for Talent Management and Industrial and Organisational Psychology practices and future research. The CPA is a tool used for the selection and development of talent nationally and internationally. Limited recent test-retest research has been done regarding the utilisation of the CPA in this context. Scholars in the field of industrial psychology could therefore benefit from follow-up research regarding the validity and reliability of the CPA. The research design is an ex post facto correlational design using longitudinal data of a sample of convenience (N=527). Overall, the results indicated a significant correlation between CLC for CPA 1 and CPA 2 as well as between Mode for CPA 1 and CPA 2. The CPA as a measure of theoretical capability is consistently accurate between measures and can be used with confidence for the identification and development of talent within organisations. / Industrial and Organisational Psychology / M. Admin. (Industrial and Organisational Psychology)

This thesis focuses on statistical and machine learning methods designed for sequential and repeated measurement data. We start off by considering the classic general linear model (MANOVA) followed by its generalization, the growth curve model (GMANOVA), designed for analysis of repeated measurement data. By considering a binary classification problem of normal data together with the corresponding maximum likelihood estimators for the growth curve model, we demonstrate how a classification rule based on linear discriminant analysis can be derived which can be used for repeated measurement data in a meaningful way. We proceed to the topics of neural networks which serve as our second method of classification. The reader is introduced to classic neural networks and relevant subtopics are discussed. We present a generalization of the classic neural network model to the recurrent neural network model and the LSTM model which are designed for sequential data. Lastly, we present three types of data sets with an total of eight cases where the discussed classification methods are tested. / Den här uppsatsen introducerar klassificeringsmetoder skapade för data av typen upprepade mätningar och sekventiell data. Den klassiska MANOVA modellen introduceras först som en grund för den mer allmäna tillväxtkurvemodellen(GMANOVA), som i sin tur används för att modellera upprepade mätningar på ett meningsfullt sätt. Under antagandet av normalfördelad data så härleds en binär klassificeringsmetod baserad på linjär diskriminantanalys, som tillsammans med maximum likelihood-skattningar från tillväxtkurvemodellen ger en binär klassificeringsregel för data av typen upprepade mätningarn. Vi fortsätter med att introducera läsaren för klassiska neurala nätverk och relevanta ämnen diskuteras. Vi generaliserar teorin kring neurala nätverk till typen "recurrent" neurala nätverk och LSTM som är designade för sekventiell data. Avslutningsvis så testas klassificeringsmetoderna på tre typer av data i totalt åtta olika fall.

This research highlights the importance of considering the degree students’ integration into school classes when estimating school effects. Combining and using two different datasets collected before and after education reform in Taiwan, the study compares school effects under two different education systems in order to answer the question about the efficiency of education reform. I estimate multilevel growth models to assess how school environments affect changes in students’ initial and change rate of their academic performance across junior high school years. Besides, two-part random-effects models are also introduced into the analyses to testify how school environment influence adolescent performance in their high school enrollments. My results support and extend Blau’s structural theory, revealed that school contexts and school networks directly and indirectly influences students’ performance in their school classes and in their high school enrollments, suggesting students’ outcome are conditioning by the local structure, the school environments. However, through making more friends inside and outside school classes, students still have their own power to modify the environmental impacts on themselves. With respect to the comparisons of school effects on individuals’ performance under two different education systems in Taiwan, the decreasing peer influences and the decreasing significance of school networks indicate that the school effects gradually decline after the administration of education reform. One should note that simply a little change on education system might alter students, parents, and teachers’ behaviors. The decreasing peer effects and the decreasing school effects on students’ academic performance suggesting that students might change their behaviors on interacting with their friends and change their behaviors at schools in order to jostle higher education after education reform. The increasing cram schooling and the increasing significance of family SES support the inference that students modify their behaviors to come up against the education reform in Taiwan. These findings suggest the need for more panel datasets collected from the newly cohorts after education reform was administrated for a period and the need for more studies of education reform and school effects, to have more understanding about the mechanisms of school efficiency.

Contexte et objectifs. La carrière criminelle est un sujet d’intérêt criminologique depuis plus de 80 ans. Les travaux sur cette question ont permis de mieux comprendre l’évolution des personnes contrevenantes et leurs crimes au fil du temps. Bien que beaucoup d’efforts aient été déployés pour étudier les hommes, les recherches portant sur les trajectoires criminelles des femmes demeurent relativement rares, ceci étant notamment attribuable à la petite taille des échantillons. L’objectif de ce mémoire est de réaliser une étude comparative de la carrière criminelle d’hommes et de femmes de 18 à 47 ans relevant de la juridiction de la province de Québec. Méthodologie. L’échantillon est composé de 3320 délinquants sous responsabilité provinciale, soit 216 femmes (6,5 %) et 3104 hommes (93,5 %). Des statistiques descriptives seront réalisées afin de dresser un portrait de la clientèle et une approche par variable latente catégorielle sera utilisée pour modéliser les parcours criminels. Plus précisément, cette analyse permet d’estimer des sous-groupes de délinquants au sein de la population qui suivent des courbes de croissance distinctes. La proportion d’individus appartenant à chacun de ces sous-groupes peut donc être estimée. Résultats. Les analyses indiquent que les femmes ont une fréquence de délits commis plus faible que les hommes, et ce, particulièrement au début de leur carrière criminelle. En effet, la différence quant à la fréquence tend à s’atténuer avec le temps, pour disparaître vers 40 ans. Également, il apparaît que les hommes et les femmes suivent un nombre de trajectoires criminelles similaires; cependant, la prévalence chez ces dernières apparaît relativement différente. En effet, il ressort que les femmes commencent plus tardivement leur carrière criminelle que les hommes, avec une proportion plus importante pour les crimes contre les biens. Finalement, les antécédents juvéniles influent sur la chronicité et la persistance, quel que soit le genre ou le type de crime. Conclusion. Les résultats démontrent que la différence selon le sexe est un sujet d’intérêt criminologique primordial puisque les femmes présentent des risques différents quant à la fréquence et au type de crime. Qui plus est, ces dernières semblent commencer leur carrière criminelle plus tardivement que les hommes. / Context and objectives. Criminal careers has been a subject of interest among criminologists for over 80 years. This research has allowed a better understanding of the evolution of criminalised individuals over time. However, research focusing on the criminal careers of women are relatively rare, this being mainly attributed to the nature of the chosen sample. While overcoming the potential limitations found in previous studies, the objective of this research is to conduct a comparative study of criminal careers among men and women (as of 18 until 47 years old) under provincial jurisdiction. Method. The sample consists of 3,320 offenders under provincial jurisdiction. The sample includes 216 female participants (6.5%) and 3104 male participants (93.5%). Descriptive statistics will be presented in order to provide a detailed portrait of offenders from 18 to 47 years old. Then, the categorical latent variable approach will be used. This type of analysis provides an estimate of sub-groups of offenders within the population that follow the growth curves separately. Thus, the proportion of individuals belonging to each of these subgroups can be estimated. Results. Women have a lower incidence of crime than men especially at the beginning of a criminal career; however this difference disappears towards the age of 40. It appears that men and women, at a certain period of time have similarities in their criminal careers. However, the prevalence of criminality among women is quite different from men. Indeed, it appears that women begin their criminal careers later than men, with a higher proportion of crimes against property. The juvenile history of criminal offence influences the perseverance in criminal careers among men and women, regardless of the type of offence. Conclusion. The results demonstrate the relevance of the difference between men and women during their criminal career. It should be one of the top interests for criminologists since women have different risks leading to offenses, as well as frequency and type of offense. Moreover, they appear to begin their criminal careers later than men.