Submitted by PPG Medicina e Ci?ncias da Sa?de (medicina-pg@pucrs.br) on 2018-12-05T13:29:31Z No. of bitstreams: 1 RUY_DE_ALMEIDA_BARCELLOS.pdf: 2171813 bytes, checksum: d242fe874538146ea8081420b788cadb (MD5) / Approved for entry into archive by Sheila Dias (sheila.dias@pucrs.br) on 2018-12-06T18:13:57Z (GMT) No. of bitstreams: 1 RUY_DE_ALMEIDA_BARCELLOS.pdf: 2171813 bytes, checksum: d242fe874538146ea8081420b788cadb (MD5) / Made available in DSpace on 2018-12-06T18:20:07Z (GMT). No. of bitstreams: 1 RUY_DE_ALMEIDA_BARCELLOS.pdf: 2171813 bytes, checksum: d242fe874538146ea8081420b788cadb (MD5) Previous issue date: 2018-09-24 / Objective: To evaluate the impact of the implantation of a checklist during multidisciplinary daily round in the period of using invasive mechanical ventilation (MV) and permanence in the ICU. Methods: In a non-randomized clinical trial with historical controls, 466 patients submitted to MV were evaluated in a Hospital in Caxias do Sul (RS). Of this total, 235 and 231 were evaluated in the pre-intervention and post-intervention phases, respectively. The outcomes studied were SAPS-3, SOFA, frequency of infections, ICU stay, days of MV, reintubations, rehospitalizations, deaths in the ICU and hospital. Results: There was a significant reduction after the routine use of the checklist in the lenght of permanence in 37.5% (p <0.001) and 60% (p <0.001) in the time of mechanical ventilation. The frequency of pulmonary focus infection was reduced by 11.9% (p = 0.030). Conclusions: The multidisciplinarity structured through the use of checklists has an impact on the reduction of the days of use of mechanical ventilation and stay in the ICU. / Objetivo: Avaliar o impacto da implanta??o de uma lista de verifica??o durante round di?rio multiprofissional nos tempos de ventila??o mec?nica invasiva (VM) e perman?ncia na UTI. M?todos: Em um ensaio cl?nico n?o randomizado com controles hist?ricos, foram avaliados 466 pacientes submetidos ? VM em um hospital em Caxias do Sul (RS). Foram avaliados 235 e 231 pacientes nas fases pr?-interven??o e p?s-interven??o respectivamente. As vari?veis estudadas foram: Simplified Acute Physiology Score (SAPS-3), Sequential Organ Failure Assessment (SOFA), frequ?ncia de infec??es, perman?ncia na UTI, dias de VM, reintuba??es, reinterna??es, ?bitos na UTI e hospitalar. Resultados: Houve redu??o significativa ap?s a implanta??o da lista de verifica??o no tempo de perman?ncia em 37,5% (p<0,001) e de 60% (p<0,001) no tempo de ventila??o mec?nica. A frequ?ncia de infec??o de foco pulmonar teve redu??o 11,9% (p=0,030). Conclus?es: A multidisciplinaridade estruturada atrav?s da utiliza??o da lista de verifica??o teve impacto na redu??o dos dias de utiliza??o de ventila??o mec?nica e perman?ncia na UTI.

Developmental delays related to feeding dysfunction in premature infants can lead to lengthy hospitalizations and increased healthcare costs initially and throughout the first year of the child's life. The purpose of this project was to use readiness-to-feed assessments to evaluate the impact of an infant-driven feeding protocol on length of stay. The project compared the length of stay of 2 groups of infants: a demand fed according to a readiness-to-feed protocol (protocol group, n = 14) and a traditionally fed according to scheduled, volume-driven feedings (traditional group, n = 15). The logic model served as the change management framework and synactive theory of infant development provided the theoretical framework. According to Als' synactive theory, a shortened hospital stay for premature infants may reduce adverse effects related to neurosensory development, delayed bonding, and a distant parenting experience. A quantitative research design was used, and data were collected through a retrospective chart review of the 2 groups. Descriptive statistics and analysis of variance were completed. The findings indicated that the length of stay in the protocol group was less than the length of stay in the traditionally fed group and that the difference was statistically significant (p = 0.03). Social change benefits related to the project include improved family bonding, improved neurosensory development of infants, and a reduction in healthcare costs as a result of a shortened length of stay. The findings of this project demonstrated that by using the readiness-to-feed protocol, neonatal intensive care nurses can decrease lengths of stay and costs of hospitalization while reducing adverse effects of traditional care on infant development and bonding.

Longer-term immigrants residing in the United States exhibit physical health decline related to higher body mass index (BMI). Theories on immigrant acculturation have been used to examine health patterns by length of stay in the United States. The purpose of this cross-sectional study, guided by the Schwartz model of acculturation, was to examine the effect of acculturation and length of stay in the United States on BMI in a sample of Haitian immigrants living in the Northeast Metropolitan area. The research question was used to examine the effects of acculturation and length of stay on BMI in the convenience sample of 116 Haitian men and women, aged 18 years and older, who had relocated to the United States for 3 years or more. Data were collected using a demographic questionnaire and medical records from a participating health clinic and then analyzed by conducting a multiple linear regression. According to study results, acculturation, length of stay, age, gender, and physical activity were not significant predictors of BMI change. An ancillary analysis using the subscales of acculturation revealed similar results. This study may provide positive social change by enabling health providers to understand the beliefs, values, and practices of Haitian immigrant groups and the acculturation pattern of individuals when providing care for this population.

Background: In high-income countries, hospital length of stay after a normal birth has gradually decreased correspondingly to length of stay in care of other patients. A short stay provides a greater opportunity for autonomy and an increased sense of participation, but it may involve great challenges satisfying parental guidance as well as on the possibility of preventing, discovering, and treating neonatal medical conditions. Aim: This study evaluates postnatal care based on cost calculations, risk assessments, and parents’ satisfaction with care. Methods: Questionnaires were sent to 1 122 new mothers and her partner during 1998-1999. For the summary of utilization of health care services during the first 28 days postdelivery, the participants were linked with registry data from the hospital administration system for mothers and newborns (n= 773). The answers were also used to describe new parents’ experiences with postnatal care (n = 1 479). The costs for five postnatal care models were estimated, including three care options: Maternity Ward, Family Suite, and Early Discharge. Data about neonatal readmissions and death within 28 days was retrieved from the Swedish Medical Birth Register, the Swedish Hospital Discharge Registry, and the Swedish Cause-of-Death Register between 1999 and 2002 (n = 197 898). This data was related to data about postnatal follow-up practices from all 48 Swedish delivery wards. Results: The readmission rate for the mothers was similar among the various care options, and there was no difference in utilization of health care or breastfeeding outcome due to type of maternity care. As a proxy for morbidity, the readmission rate for the newborns was influenced by postdelivery follow-up routines as routine neonatal examination timing. Depending on the proportion of mothers receiving care at the Maternity Ward, the costs differed significantly between the various care models, while parents’ preferences complied with the cost-minimizing option Family Suite. Most mothers and fathers (70%) were satisfied with the overall impression of the postnatal care, but 72% were dissatisfied with at least one particular topic. A main finding was that the parents experienced a close emotional attachment, an affinity that was not always supported by the staff. The father was not treated as a principal character even though the parents wanted the father’s to be involved and recognized. Conclusions: Since the postnatal care options are not always the most cost minimizing and postnatal routines influence neonatal morbidity and parental satisfaction, the postnatal services need to be improved. Without increasing risks or costs, every postnatal care option ought to meet the families’ need for support, security, autonomy, and attachment with each other.

SAMMANFATTNING Trakeotomi är ett operativt ingrepp och innebär att man gör ett strupsnitt på halsens framsida för att skapa fri luftväg. Denna öppning, trakeostoma, som skapats på halsen hålls öppen av en trakealkanyl. Trakealkanylen sitter i luftstrupen och skapar patientens artificiella andningsväg. Trakeostomi är ett ingrepp som ökar i Sverige och görs när sjukdomar eller skador i luftvägarna eller i centrala nervsystemet försämrar eller hindrar patienten från att andas genom näsan och munnen. Ingreppet genomförs också på patienter som behöver långvarig respiratorbehandling. Komplikationer av olika allvarlighetsgrad förekommer hos trakeostomerade patienter. Vård av trakeostomerade patienter är komplext och kräver ibland fördjupad förståelse och specialistkunskap av varje enskilt aspekt och därför kan samverkan i team mellan olika professioner behövas för professionellt omhändertagande. Syftet med denna studie var att beskriva vilken effekt multidisciplinärt trakeostomiteam har på vården av trakeostomerade patienter. Studien är en litteraturöversikt och sökning av de 15 inkluderade artiklarna genomfördes i PubMed och CINAHL. Majoriteten av de inkluderade artiklarna är baserade på observationsstudier där data insamlades retrospektivt. Litteraturöversikten resulterade i följande beskrivna effekter av multidisciplinärt trakeostomiteam på vården av trakeostomerade patienter, minskade komplikationer av olika allvarlighetsgrad. De minskade vårdtiden, den totala längden på sjukhusvistelse, vistelsetid efter utskrivning från intensivvårdsavdelningen och den totala tiden på intensivvårdsavdelningen. Teamet bidrog även till snabbare handläggning och beslut om dekanylering, förbättrade kommunikationsmöjligheter för patienten men även bättre kommunikation inom teamet. Utöver detta utarbetade och implementerade teamet kliniska riktlinjer och ansvarade för utbildning av personal, patienter och anhöriga. Några få studier visade även på kostnadseffektivitet. Resultatet av denna litteraturöversikt visade att multidisciplinärt trakeostomiteam har positiva effekter i vården av trakeostomerade patienter framförallt i form av minskade komplikationer och reducerad vårdtid. Teamet bidrar även till effektivare dekanyleringsprocess och snabbare initiering av talventil. Men dessa effekter måste tolkas med stor försiktighet pga. de inkluderade studiernas metodologiska svaghet och för att resultaten inte rakt av går att generalisera och överföra till svenska förhållanden och sjukvård.

Thesis (D.P.H.)--University of Michigan.

Thesis (D.P.H.)--University of Michigan.

Thesis (Ph. D.)--RAND Graduate School, 1998. / Includes bibliographical references (p. 241-258).

Neutropenia febril (NF) constitui complicação frequente do tratamento quimioterápico do câncer e está associada a altas taxas de morbimortalidade. O reconhecimento dos principais fatores associados ao desenvolvimento de desfechos clínicos desfavoráveis na NF é fundamental, uma vez que estes podem ser utilizados como marcadores prognósticos ou alvos terapêuticos. Este estudo objetiva determinar os principais fatores associados com mortalidade, tempo de hospitalização, incidência de bacteremia por patógenos multirresistentes e incidência de choque séptico no início da febre em pacientes hospitalizados com NF secundária à quimioterapia citotóxica para o câncer. Na presente coorte prospectiva composta por 305 episódios consecutivos de NF (em 169 pacientes com câncer) realizada em um hospital terciário no período de outubro de 2009 a agosto de 2011, as seguintes questões de pesquisa foram avaliadas: impacto do tempo de início da antibioticoterapia na mortalidade em 28 dias; fatores relacionados com tempo de hospitalização; impacto dos fatores microbiológicos da bacteremia no desenvolvimento de choque séptico no início do episódio de NF; fatores de risco para bacteremia por patógenos multirresistentes; impacto da bacteremia por Staphylococcus coagulase-negativo na mortalidade em 28 dias. Em 5 publicações distintas, os seguintes resultados foram notados: o atraso do início da antibioticoterapia está associado a maiores taxas de mortalidade em 28 dias; neoplasia hematológica, regimes quimioterápicos de altas doses, duração da neutropenia e bacteremia por Gram-negativos multirresistentes estão associados com períodos prolongados de internação por NF; infecção de corrente sanguínea polimicrobiana, bacteremia por Escherichia coli e bacteremia por Streptococcus viridans estão associados a choque séptico no início do episódio de NF; idade avançada, duração da neutropenia e presença de cateter venoso central estão associados com bacteremia por patógenos multirresistentes; bacteremia por Staphylococcus coagulase-negativo está associada a menores taxas de mortalidade em 28 dias quando comparado à bacteremia por outros patógenos. / Febrile neutropenia (FN) is a common complication of cancer chemotherapy and is associated with high morbidity and mortality rates. Recognition of the main factors associated with the development of adverse clinical outcomes in FN is crucial, given that these factors can be used as prognostic markers or therapeutic targets. This study aims to determine the main factors associated with mortality, length of hospital stay, incidence of bacteremia by multidrug-resistant pathogens and incidence of septic shock at the onset of fever in hospitalized patients with FN secondary to cancer cytotoxic chemotherapy. In the present prospective cohort of 305 FN episodes (in 169 cancer patients) conducted at a tertiary hospital from October 2009 to August 2011, the following research questions were evaluated: impact of time to antibiotic administration on 28-day mortality; factors associated with length of hospital stay; impact of microbiological factors of bacteremia on the development of septic shock at the onset of FN; risk factors for bacteremia by multidrug-resistant pathogens; impact of coagulasenegative Staphylococcus bacteremia on 28-day mortality. In 5 distinct publications, the following results were noted: delay of antibiotic administration is associated with higher 28-day mortality rates; hematologic malignancy, high-dose chemotherapy regimens, duration of neutropenia and bacteremia by multidrug-resistant Gram-negative bacteria are associated with prolonged length of hospital stay; polymicrobial bloodstream infection, bacteremia by Escherichia coli, and bacteremia by viridans sreptococci are associated with septic shock at the onset of FN; advanced age, duration of neutropenia and presence of indwelling central venous catheters are associated with bacteremia by multidrug-resistant pathogens; coagulase-negative Staphylococcus bacteremia is associated with lower 28-day mortality rates compared with bacteremia by other pathogens.

Introdução: Complicações respiratórias são comuns no pós-operatório de cirurgias abdominais. Identificar os fatores de risco para tal possibilita à equipe de saúde adotar medidas protetivas, a fim de reduzir a chance de complicações e suas implicações. Objetivo: Identificar fatores de risco para complicações respiratórias no pós-operatório de cirurgias abdominais. Metodologia: Estudo de coorte retrospectivo realizado por busca em prontuário eletrônico de indivíduos adultos submetidos à cirurgia abdominal no período de Janeiro a Julho de 2016. Os dados foram analisados através do software estatístico SPSS 20.0. Para teste de normalidade foi utilizado Shapiro-Wilk, para comparação entre grupos teste de X² e t-test, para cálculo de razão de chance foi utilizada regressão logística multivariada. Considerou-se significativo p<0,05. Resultados: No período estudado foram realizadas 1586 cirurgias, sendo os pacientes 55,7% do sexo feminino com idade média de 52,12±16,56 anos. Após a cirurgia, 17,7% dos pacientes apresentaram alguma complicação respiratória; sendo a mais prevalente atelectasia. Identificou-se como fator de risco independente para o surgimento de complicações respiratórias a realização de cirurgia aberta, cirurgia de emergência, presença de pneumopatia crônica, ASA≥3, incisão supraumbilical, IMC≤21kg/m², tabagismo, idade e tempo de cirurgia. Os indivíduos que apresentaram complicações respiratórias permaneceram mais tempo hospitalizados e apresentaram maior mortalidade. Conclusão: Cirurgias abdominais realizadas por laparoscopia estão relacionadas a um menor risco de complicações respiratórias, enquanto que a presença de pneumopatia crônica é o principal fator de risco entre comorbidades. Complicações respiratórias elevam o tempo de internação e a mortalidade. / Introduction: Postoperative respiratory complications are common after abdominal surgeries. Identify risk factors helps the health team to adopt protective measures in order to reduce the chance of complications and its implications. Objective: Identify risk factors for postoperative respiratory complications after abdominal surgeries. Methodology: A retrospective cohort study was carried out by searching electronic medical records of adult subjects submitted to abdominal surgery from January to July 2016. Data were analyzed using statistical software SPSS 20.0. For the normality test, Shapiro-Wilk was used to compare groups of categorical variables. X² test was used and for continuous variables, t test for independent variables and multivariate logistic regression was used to calculate odds ratios. Significant p<0.05 was considered. Results: During the study period, 1586 surgeries were performed, 55.7% female patients with a mean age of 52.12±16.56 years. After surgery, 17.7% of the patients presented one or more respiratory complications; the most common was atelectasis. Independent risk factors identified were open surgery, emergency surgery, chronic lung disease, ASA≥3, supraumbilical incision, BMI≤21kg/m², smoking, age and surgery time. Subjects with respiratory complications presented higher length of stay and mortality. Conclusion: Abdominal surgeries performed by laparoscopy are related to a lower risk of respiratory complications, while the presence of chronic lung disease is the main risk factor among comorbidities. Respiratory complications increase length of hospital stay and mortality.