The objective of the present study is to understand the dynamics of the elaboration of the territorial tourism that occurs between Brasília and Goiânia. It is crucial to discuss not only space and physical structures, but it is also important to verify how the different touristic activities can be distinguished. This thesis will show that there exists a sort of touristic activity that organizes space in the surrounding suburbs of Distrito Federal. The main cities in the urban region, respectively Brasília and Goiânia have strong influence over the nearest counties, and tourism is one of the diverse manifestations of this territorial dynamic. As the culture of travel settles in the urban metropolitan centers, there are certain demands that are created to attend the need of utilization of free time including pleasure and touristic activities. In this manner, the nearby counties start receiving public and private investments so that they can offer infrastructure and attractions for the expanding market segment. Tourism is able to create structures for its own consolidation according to the local specific aspects (political issues, attractive activities, entrepreneurs) showing thus a hierarchy between the touristic counties and those with developing activities. Data was gathered in the official tourism organs in the counties of research as well as in the State of Goiás, Distrito Federal and at the Ministry of Tourism. The first chapter of this thesis briefly describes the research theme, methodology, objectives and the difficulties encountered throughout this research. The second chapter defines tourism and its facets in a light manner so that the subject is not dense. In the third chapter there is a characterization of the area between Brasilia and Goiania. The following chapters will show the different levels of the development of tourism in the counties of Goiás, with a basis on the characterization of the social economic indicators, the tourism attractions and the current stage of development of the touristic activity. In the last two chapters, the different uses and possibilities of tourism between Brasilia and Goiania are discussed, as well as the understanding if there is in fact a touristic region of Brasilia, besides the conclusions that truly prove that tourism produces a territorial dynamic that occupies spaces in detriment to other spaces, causes developments and contradictions. / O presente trabalho tem por objetivo compreender a dinâmica da produção territorial do turismo no eixo Brasília-Goiânia. Pensamos que além do espaço, base física, faz-se necessário, também, discutir em que medida as possibilidades de desenvolver a atividade turística na região podem ser pontuadas. A tese a ser discutida é a de que existe uma atividade turística que ordena o espaço no Entorno do Distrito Federal. As cidades-cabeça da rede urbana regional, respectivamente Brasília e Goiânia, exercem forte influência sobre os municípios mais próximos, sendo o turismo uma das diversas manifestações dessa dinâmica territorial. Na medida em que a cultura do viajar se instala nos centros urbanos metropolitanos, criam-se demandas direcionadas a atender essa necessidade de utilização do tempo-livre com atividades de turismo e lazer.Portanto, os municípios próximos passam a receber investimentos públicos e privados para oferecer infra-estrutura e atrativos ao mercado em expansão. O turismo cria estruturas para sua consolidação de acordo com as especificidades locais (questões políticas, atrativos, empreendedores), denotando assim uma hierarquia com municípios turísticos e em desenvolvimento da atividade. Foram feitos levantamentos de dados junto aos órgãos oficiais de turismo nos municípios pesquisados bem como no Estado de Goiás, Distrito Federal e no Ministério do Turismo. Inicialmente, no primeiro capítulo faz-se uma breve discussão sobre o tema da pesquisa, metodologia, objetivos e as dificuldades encontradas. No segundo capítulo é feita uma breve digressão sobre o turismo e suas facetas, sem a pretensão de esgotar o assunto. No terceiro capítulo, há a caracterização do eixo Brasília-Goiânia. Os capítulos seguintes irão mostrar os diferentes níveis de desenvolvimento do turismo nos municípios goianos, a partir da caracterização de seus indicadores socioeconômicos, os atrativos turísticos e o atual estágio de desenvolvimento da atividade. Nos dois últimos capítulos, discutem-se os diferentes usos e possibilidades do turismo no eixo, bem como se há de fato a região turística de Brasília , além das conclusões que comprovam que de fato o turismo produz uma dinâmica territorial que ocupa espaços em detrimento de outros, produz desenvolvimento e contradições. / Doutor em Geografia

A dual-axis fluidic thrust vectoring (FTV) system is proposed where the supersonic propulsive jet of an aircraft is exhausted over a scarfed (swept), curved surface to produce flight control moments in both the pitch and yaw axes. This work contributes towards practical dual-axis FTV through expansion of fundamental curved-wall jet (CWJ) understanding, development of the novel Superimposed Characteristics technique for supersonic nozzle design, and performance evaluation of an experimental scarfed curved wall FTV configuration. Previous work has suggested that the use of a sheared exhaust velocity profile improves the attachment of supersonic jets to curved surfaces; however, evidence to support this is limited. To address this, an inviscid numerical CWJ model was developed using the two-dimensional method of characteristics. A major outcome is improved understanding of the effect of exhaust velocity profile on CWJ wave structure and subsequent jet attachment. A sheared velocity exhaust is shown to generate a wave structure that diminishes adverse streamwise pressure gradients within a supersonic curved-wall jet. This reduces the likelihood of boundary layer separation and as a result, a sheared exhaust velocity CWJ is expected to be less readily separated compared to other exhaust velocity profiles. A novel method termed Superimposed Characteristics was developed for the low-order design of supersonic nozzles with rectangular exits. The technique is capable of generating 3D nozzle geometries based on independent exit plane orientation and exhaust velocity distribution requirements. The Superimposed Characteristics method was used to design scarfed rectangular exit nozzles with sheared velocity exhaust profiles. These nozzles were then evaluated using finite volume computational methods and experimental methods. From the analysis, the Superimposed Characteristics method is shown to be valid for preliminary nozzle design. Experimental methods were used to study the on- and off-design attachment qualities of uniform and sheared velocity exhaust jets for a FTV configuration with an external curved wall termination angle of 90 degrees and scarf angle of 30 degrees. Experiments at the on-design nozzle pressure ratio (NPR) of 3.3 demonstrated pitch and yaw jet deflection angles of 78 degrees and 23 degrees respectively for the uniform exhaust velocity CWJ. The sheared exhaust velocity CWJ achieved lower pitch and yaw deflection angles of 34 degrees and 14 degrees respectively at the same on-design NPR. The lower jet deflection angles observed for sheared exhaust velocity jets is inconsistent with the CWJ model prediction of reduced adverse streamwise pressure gradients; however, there was insufficient experimental instrumentation to identify the cause. In the off-design experiments, the uniform exhaust velocity CWJ was observed to detach at an NPR of 3.6, whilst the sheared exhaust velocity CWJ remained attached at NPRs in excess of 4. The capability of sheared exhaust velocity CWJs to remain attached at higher NPRs is consistent with the analytical theory and the CWJ model predictions. An actuation study was carried out to achieve controlled jet detachment using secondary blowing injected normal to the curved wall. Full separation of the wall jets was achieved downstream of the injection point. This provided vectoring angles of more than 20 degrees in pitch and 10 degrees in yaw, exceeding expected vectoring requirements for practical aircraft control. At the on-design NPR, the uniform and sheared exhaust velocity jets required secondary blowing mass flow rates of 2.1% and 3.8% of the primary mass flow respectively to achieve full separation.

La respiration est un phénomène vital qui implique une synergie entre diverses structures anatomiques qui constituent le thorax. La physiologie articulaire reste un parent pauvre de la physiologie et la littérature concernant la quantification de la cinématique 3D des articulations du thorax durant le mouvement respiratoire est rare. Ce travail se concentre sur le développement et l'application d'une méthodologie permettant de répondre à cet objectif. La méthode développée combine le traitement de données tomodensitométriques réalisées à trois volumes pulmonaires différents et des techniques d'infographies. Les amplitudes (ROMs) et axes de mouvements (axe hélicoïdaux moyen, AHMs) ont été obtenus au niveau des articulations costo-vertébrales de 12 sujets asymptomatiques. En résumé, les amplitudes diminuent graduellement dans les étages inférieurs ; le volume pulmonaire et l'étage costal influencent significativement les amplitudes costales ; l'orientation des AHMs ne diffère pas entre les étages costaux. En complément, la méthode a été appliquée pour un échantillon de 10 patients atteints de mucoviscidose. La condition pathologique influençait significativement les amplitudes de mouvements mais pas l'orientation des AHMs. Enfin, le déplacement sternal, les variations de l'angle sternal et la cinématique des articulations sternocostales a été analysée. Les déplacements angulaires des côtes par rapport au sternum diminuaient dans les étages inférieurs comme au niveau des articulations costo-vertébrales. L'orientation des AHMs des articulations sternocostales ne différait pas entre les étages. Une corrélation linéaire a été mise en évidence entre les déplacements verticaux du sternum et les amplitudes de mouvement costales au niveau costo-vertébral et sternocostal. Ce travail contribue de façon substantielle à la modélisation 3D du thorax humain durant le mouvement respiratoire d'un point de vue qualitatif et quantitatif / Breathing is a vital phenomenon that implies synergy of various anatomical structures that constitute the thorax. Joint physiology remains a relatively poorly-known component of the overall thorax physiology. Quantitative literature related to in vivo thorax kinematics during breathing is scarce. The present work focuses specifically on developing and applying a methodology to reach this goal. The developed method combined processing of CT data obtained at different lung volumes and infographic techniques. Detailed ranges of motion (ROMs) and axes of movement (mean helical axes, MHAs) were obtained at costovertebral joints in 12 asymptomatic subjects; rib ROMs gradually decrease with increasing rib number; lung volume and rib level have a significant influence on rib ROM; MHAs did not differ between rib levels. In addition, the method was applied on a sample of 10 patients with cystic fibrosis. The pathological condition significantly influenced CVJ ROMs while the orientation of the MHAs did not differ. Finally, the sternal displacement, sternal angle variations and sternocostal joints (SCJ at rib1 to 7) kinematics during breathing motion were analyzed. Rib ranges of motion relative to sternum decreased with increasing rib number similarly to CVJ. Orientation of the MHAs did not differ between SCJ levels. A significant linear correlation was demonstrated between sternum vertical displacement and rib ranges of motion at both CVJ and SCJ. The present work substantially contributes to 3D modelling of human thorax in breathing at a joint level both qualitatively and quantitatively

Les nouveaux neurones de l’hippocampe semblent contribuer à l’action thérapeutique des antidépresseurs. La nature fonctionnelle de cette contribution est cependant inconnue. En stimulant la neurogenèse les antidépresseurs pourraient renforcer certaines fonctions de l’hippocampe et ainsi permettre la rémission. Nous montrons dans ce travail que les nouveaux neurones peuvent contribuer à l’action thérapeutique des antidépresseurs en participant au renforcement de rétrocontrôle hippocampique sur la régulation de l’axe HPA, potentiellement via leur rôle dans la capacité de l’hippocampe à moduler l’activité des autres structures impliquées dans la régulation du stress, comme le noyau du lit de la strie terminale. Les différentes composantes fonctionnelles de l’hippocampe sont cependant topographiquement distribuées le long de son axe septo-temporal. A travers une approche corrélative nous avons montré que différents antidépresseurs régulent la neurogenèse différentiellement le long de l’axe septo-temporal. Cela suggère des mécanismes de régulation régiondépendants et que la contribution des nouveaux neurones dans les effets des antidépresseurs pourrait être multiple et sous tendue par des composantes fonctionnelles différentes, et non limitée à la régulation de l’axe du stress. / Hippocampal newborn neurons contribute to some extent to the therapeutic effects of antidepressants. Mechanisms involved in this contribution remain however elusive. By increasing the recruitment of newborn neurons antidepressants could improve several hippocampal functions and thus allow remission. Here we demonstrate that newborn neurons may contribute to the therapeutic effects of antidepressants by allowing the recovery of a proper hippocampal inhibitory feedback over the HPA axis, possibly by normalizing the communication between the hippocampus and stress integrative structures mediating its inhibitory influence, such as the bed nucleus of the stria terminalis. Hippocampal functions are however topographically segregated along its septo-temporal axis. Here we show that different mood-improving manipulations differentially regulate neurogenesis along this septo-temporal axis. This suggest different region-specific mechanisms involved in the regulation of neurogenesis and that newborn neurons may contribute to the therapeutic effects of antidepressants by modulating different aspects of hippocampal functions.

Heterogeneous Objects are engineered with multiple materials to achieve multiple functionalities like high hardness, high toughness and low structural weight. Heterogeneous objects are increasingly used to achieve multiple and often conflicting behaviour within a single object. Developing heterogeneous objects needs computational model for design, analysis and manufacturing. The computational model should map the geometry of the object with the material composition. The most general model is the volume based model that decomposes the geometry exhaustively into simple elements and defines the material distribution over these elements. This approach can model a wide range of objects. However, defining material distribution needs manual intervention to select these elements for material continuity, and to segment or subdivide them for better material approximation. Volume based representation is quite large in size and is cumbersome to edit, query or reuse. Feature based approaches have been proposed to address some of these issues. However, current art can model only limited class of Heterogeneous Objects that includes simple material distribution over complex geometry or complex material distribution over simple geometry. The thesis presents a new method to overcome these limitations. The method, a hybrid of volume based and feature based approaches, allows the user to define the complex material distribution over complex geometries intuitively and represent the same. The complex material distribution is modelled using material reference entities that may be mixed-dimensional, inclusive of non-manifold entities. It uses Medial Axis Transform for automated segmentation of these entities into independent regions, where the material distribution can be intuitively prescribed starting from the entity and terminating at the medial axis. The spatial variation of the material is captured by a parameterized distance field from the material reference entities. It develops new constructive operators to build a complex heterogeneous object model that allows the reuse of the existing heterogeneous object models, automates handling of material continuity, and controls the gradation of the material in the interface of the constituent heterogeneous objects. Constructions using these operators can be geometry driven or material driven i.e. the geometric form controls the material distribution or the material distribution is independent of the geometric form. The proposed representation can be adaptively meshed for generation of mesh in the direction of gradation of the material for finite element analysis and process planning for additive manufacturing. An iso-material contour representation has been proposed for process planning of Heterogeneous Object Models. This avoids the stair case effect by depositing material in the direction of material gradation, and avoids over-deposition or under-deposition due to frequent start and stop of the nozzles. The proposed method has been implemented to show that it can model wide range of heterogeneous objects and can be integrated with additive manufacturing.

Over the years stress has been a term lacking one clear and specific definition. In general, the term stress has been used mostly as an explanation of a response or reaction to a stressor. A stressor can be of both physiological and behavioral character. The experience of stress can occur both due to a real or a perceived stressor. In this literature review, the concept of stress is viewed with insights from biological, psychological, and social perspectives. The stress response is described biologically with the central nervous system (CNS), the brain, and the hypothalamic-pituitary-adrenal (HPA) axis. Social and psychological stress are concepts related to how stress is perceived by the mind and due to social surroundings which is described in relation to social support, self-efficacy, the locus of control and cognitive appraisal. Dealing with stress can be done through coping which refers to the individual capacity to handle a stressor and has generally been divided into two categories, active/passive coping and problem-focused/emotion-focused coping. Depending on the individual resources to cope with a stressor and the ability to decrease the stress response when needed, the long-term effects of stress can therefore vary between individuals. It has been found that positive coping (known as reducing stress) can increase the anterior cingulate cortex (ACC) volume and decrease anxiety and depression. The prefrontal cortex (PFC), the hippocampus, and the amygdala are closely linked to the ACC and affect emotions, learning, and memory related to the stress response.

The presented dissertation consists of both a quantitative part and a qualitative part. The quantitative part deals with the relationship between 5-HTTLPR S/L, MAOA H/L, and COMT Val158Met polymorphisms, the stress reaction of new-born infants after a heel stick blood draw (measured by determining salivary cortisol at three time points) and temperament assessed at age three months by Rothbarth's Infant Behavior Questionnaire-Revised in a sample of 84 infants. Observed polymorphisms were related both to the course of the stress reaction and to temperament. The short allele of serotonin transporter polymorphism was connected to higher scores in the secondary scale of Negative Affect and lower scores in the secondary scale of Attention/Regulation. Homozygotes for the more active allele of MAOA polymorphism (HH) had the lowest scores in Negative Affect compared to both of the remaining groups, they also had higher scores in the secondary scale of Extraversion and Attention/Regulation and a greater decrease of cortisol in comparison to HL heterozygotes. The presence of low-active L allele predisposed their carriers to higher scores in Negative Affect and lower scores in Attention/Regulation. LL homozygotes had the highest increase of cortisol after a heel stick blood draw. The Met allele of COMT Val158Met polymorphism was connected to higher Extraversion and Attention/Regulation and a greater cortisol decrease. It was possible to predict all three secondary scales of IBQ-R from the stress reaction after the heel stick blood draw. Negative Affect was predicted by a higher increase and a lower decrease of cortisol. Extraversion and Attention/Regulation were predicted by a greater cortisol decrease. The magnitude of cortisol decrease partially mediated the influence of COMT Val158Met polymorphism on Extraversion. The qualitative part of the dissertation is a multi-casuistic study of six couples parenting infants with difficult temperaments. It is based on semi-structured interviews that were analysed in accordance with qualitative procedures. The most difficult infant displays to manage were unsoothable crying in the first six months and early sleeplessness and a later escalation of sleeping problems. Mothers were esentially not able to gain control over the amount of crying, but some of them managed to influence their experience to achieve a greater acceptance of it. To do this, it was necessary for them to eliminate their feelings of failure in the parental role. The parents' biggest dilemma concerning their infants' sleeping problems was whether to use the "cry it out" strategy or not to manage them. For some parents parenting a difficult infant was an opportunity to re-evaluate their approach to parenting and the parental role, significantly broadening the concept of both. Caring for a difficult infant significantly strained the marital relationship; four couples experienced marital crisis during the care of their child. The father's involvement in infant care seemed very important in this respect. Insufficient involvement led to dissatisfaction in the mother, the way the mother communicated her demands further influenced the marital relationship. Particular behaviour that the mother understood as the father's involvement in infant care emerged.

Contexto: As oscilações hormonais ao longo da vida estão associadas às variações de humor em mulheres normais. O estrógeno (E) parece estar associado aos níveis de fator neurotrófico derivado do cérebro (BDNF) em voluntárias saudáveis. No entanto, essa associação não foi investigada em pacientes com transtorno bipolar (TB). Sabe-se que os episódios de humor do TB estão associados a alterações dos níveis de BDNF; entretanto, não está claro o papel dos hormônios femininos. Objetivo: investigar a existência de uma possível associação entre os níveis de BDNF e os níveis de hormônios do eixo hipotálamo-hipófise-gonadal em mulheres com TB, incluindo pacientes durante o período reprodutivo e também na pós-menopausa. Métodos: Mulheres eutímicas (HAM-D e YMRS com escores menores que 8) com transtorno bipolar I(TB I), II (TB II) ou transtorno bipolar sem outra especificação (TB SOE) foram incluídas. As pacientes em idade reprodutiva tinham ciclos menstruais regulares (CMR) e não faziam uso de nenhum tipo de contracepção hormonal (CH); e as na pós-menopausa não estavam em uso de terapia de reposição hormonal (TRH). Condições endócrinas instáveis foram consideradas um fator de exclusão. Todas as pacientes estavam em tratamento farmacológico, associado ou não a intervenções psicossociais. Amostras de sangue foram retiradas para as medidas de BDNF, estrogênio (E), progesterona (P), LH e FSH, sendo coletadas nas fases folicular (FF) e lútea (FL) do ciclo menstrual, e uma única vez nas mulheres na pós-menopausa. Os diagnósticos foram confirmados através de entrevista clínica estruturada para o DSM-IV Transtornos do Eixo I (SCID-I), administrado por investigadores treinados. Resultados: Foram avaliadas 96 pacientes com TB. Destas, 64 não preenchiam critérios de inclusão ou apresentavam fatores de exclusão. Foram estudadas 32 mulheres com idades entre 22 e 69 anos (média = 52,78 anos). Considerando toda a amostra, o BDNF apresentou uma correlação positiva com os níveis de estradiol (r = 0,36, p = 0,043). Nas pacientes em período reprodutivo, na fase lútea(FL), houve uma correlação negativa entre o BDNF e o FSH (r = 0,831, p = 0,040). Um resultado semelhante foi encontrado com os níveis de LH (r = 0,908, p= 0,012) nessa mesma fase do ciclo menstrual. Conclusão: Os resultados encontrados na amostra de mulheres com TB foram semelhantes aos descritos na literatura em indivíduos saudáveis, que também apresentam correlação entre E e BDNF (Begliuomini et al., 2007). Estes achados indicam que o estímulo estrogênico pode ser importante na manutenção de s níveis fisiológicos de BDNF. A partir desses resultados novas vias devem ser incluídas na investigação na fisiopatologia das alterações de humor relacionadas a variações hormonais, bem como ao tratamento do TB. Além disso, ressalta a importância de incluir as variações hormonais femininas na equação diagnóstica e prognóstica do TB. / Background: Background: Hormonal oscilations across lifetime have been associated with mood variations in healthy women. Oestrogen (E) seems to be associated with Brain Derived Neurotrophic Factor (BDNF) levels in healthy volunteers. This assictaion was not studied in women with Bipolar Disorder (BD). Mood episodes of BD are associated with reductions in BDNF levels, although the role of feminine hormones in pathophysiology of BD hás not been completely studied. Objective: To investigate the association between BDNF levels and hormones involved in hypothalamus-pituitary-gonadal axis in women with BD, comparing a group during reproductive years with a menopausal group. In addition, differences across the two phases of menstrual cycle were also evaluated in the group during reproductive years. Methods: Women euthymic (HAM-D and YMRS scoring less than 8) with bipolar I, II or bipolar disorder not otherwise specified were included. Patients of reproductive age had regular menstrual cycles (RMC) and did not use any type of hormonal contraception (CH) and postmenopausal were not using hormone replacement therapy (HRT). Endocrine instable conditions were considered an exclusion factor. All patients were on pharmacotherapy, associed or not with psychosocial interventions. Blood samples withdrawn for measures of BDNF, oestrogen (E), progesterone (P), LH and FSH levels, being collected in the follicular phase (FP) and luteal (FL) of the menstrual cycle, menopausal women were held only one blood sample. Diagnoses were assessed using structured clinical interview for DSM-IV Axis I Disorders (SCID-I), administered by certified investigators. Results: Ninety six patients with BD were evaluated, of these, 64 did not meet inclusion criteria or met exclusion factors. The sample was constituted by 32 women with BD aged 22 to 69 years (mean = 52.78 years). Considering the whole sample, the BDNF was significantly correlated with estradiol levels (r = 0.36, p = 0.043). In patients in reproductive period, in the luteal phase, there was a negative correlation with FSH (r = 0.831, p = 0.040). A similar result was found with levels o LH (r = 0.908, p = 0.012) in the same menstrual cycle phase. Conclusion: The results found in the sample of women with TB were similar to those previously reported in healthy subjects, which also show a correlation between E and BDNF (Begliuomini et al., 2007). These findings indicate that estrogenic stimulation may be important in maintaining physiological BDNF levels. From these results, new avenues should be included in research on the pathophysiology of mood swings related to hormonal changes as well as the treatment of TB. Furthermore, the importance of including female hormonal changes in the equation of TB diagnostic and.

O experimento Unsteady Aerodynamics Experiment Phase VI, realizado no ano de 2000 pelo Laboratório Nacional norte-americano para as Energias Renováveis (NREL) no túnel de vento Ames da NASA, foi reproduzido numericamente neste trabalho. O objetivo é o estudo das características da esteira aerodinâmica produzida pela turbina eólica de duas pás e 10 metros de diâmetro, operando à velocidade de rotação constante de 72 RPM, sujeita a uma velocidade de corrente livre do vento uniforme de 9 m/s, em um túnel de vento cuja seção de testes mede 36,6 m de largura por 24,4 m de altura e o comprimento mede 170 m. Para isso, foi utilizado o programa comercial ANSYS FLUENT versão 13.0, baseado no Método dos Volumes Finitos para a solução numérica das Equações de Navier-Stokes em regime transiente em conjunto com a Simulação de Grandes Escalas (SGE) para resolver a turbulência. As geometrias de todos os componentes da máquina foram criadas em software CAD. Um domínio móvel em forma de disco, contendo as pás do rotor e o hub da máquina, foi criado separadamente, e posteriormente inserido no domínio principal, estático, usando a ferramenta Moving Mesh disponível no software FLUENT. Ambos os domínios foram preenchidos por malhas compostas por tetraedros. Dados provenientes das simulações numéricas foram comparados aos dados experimentais de velocidade fornecidos por dois anemômetros sônicos instalados 5,8 m à jusante do rotor, ao que foi verificada boa concordância, com diferenças da ordem de 1% para o anemômetro 1 e 6% para o anemômetro 2. Resultados de velocidade na linha de centro do túnel e perfis de velocidade à jusante foram comparados com recente estudo numérico, e revelam diferenças importantes entre dados obtidos pela SGE, principalmente no que se refere à detecção de picos e flutuações relacionados às escalas turbulentas, e dados obtidos através da modelagem clássica da turbulência, RANS. As perturbações ultrapassaram a marca dos 10 diâmetros à jusante e atingiram o final do domínio localizado a 15 diâmetros. A esteira não apresentou simetria axial, e o ponto de maior redução na velocidade do escoamento foi detectado fora da linha de centro do rotor. / The Unsteady Aerodynamics Experiment Phase VI, which has been carried out in 2000 by the US National Renewable Energy Laboratory (NREL) at the NASA Ames wind tunnel, has been numerically reproduced. The purpose of this work is to study the characteristics of the wind wake produced by the 10 meter two bladed wind turbine, operating at a constant rotational speed of 72 RPM, subject to a free stream wind velocity of 9 m/s, inside a wind tunnel in which dimensions are 36.6 m in width, 24.4 m in height and length of 170 m. To achieve that, the ANSYS FLUENT version 13.0 commercial code, based in the Finite Volume Method to numerically solve the Navier-Stokes equations in transient state, has been used, together with the Large Eddy Simulation (LES) to characterize the turbulence. Geometries of all the machine components have been created in CAD software. A disc shaped moving domain, containing the blades and hub, has been created separately, and later inserted into the main, static domain, using the Moving Mesh tool available in the software. Both domains have been filled with meshes composed by tetrahedra. Data collected at the numerical simulations have been compared to experimental wind speed data provided by two sonic anemometers installed 5.8 m downstream from the rotor, for which a good agreement has been found, with differences of approximately 1% to the anemometer 1 and 6% to the anemometer 2. Results of wind velocity at the tunnel centerline and velocity profiles downstream have been compared with recent numerical study, and show important differences between data obtained by LES, especially with regard to the detection of peaks and fluctuations related to the turbulent scales, and data obtained by the classic turbulence modeling, RANS. Disturbances have passed the 10 diameter mark and reached the end at the domain located at 15 diameters. The wake did not show axial symmetry and the point of maximum reduction in the flow speed was detected outside the rotor centerline.

Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Science Author: Marcela Čuchalová Supervisor: doc. MUDr. Josef Herink, DrSc. Title of diploma thesis: The hypothalamic - pituitary - gonadal axis and epilepsy: mutual relationships The content of the diploma thesis is an overview of the anatomy and physiology of the hypothalamic-pituitary-gonadal axis (HHG). Further chapters are devoted to the influence of epilepsy on HHG function, the effect of HHG hormones on epileptic activity itself. The effect of anti-epileptics on HHG functions will also be elucidated. The second part of the diploma thesis deals with separate chapters - catamenial epilepsy and epilepsy during pregnancy. Keywords: antiepileptic drugs, gonadotropin, hypothalamic-pituitary-gonadal axis, prolactin, sex hormones, temporal lobe epilepsy.