This thesis investigates issues affecting grid synchronisation of VSC-HVDC systems with particular regard to, but not limited to, offshore wind power generation during the complex but potentially serious behaviours following solar storms. An averaged value model (AVM) for the contemporary modular multilevel converter (MMC) based VSC-HVDC system is developed and is used in combination with different phase-locked loop (PLL) models and the unified magnetic equivalent circuit (UMEC) transformer model to assess the impacts of geomagnetically induced current (GIC) on grid synchronisation of an offshore VSC-HVDC system. GIC is DC current flowing in the earth caused by strong geomagnetic disturbance events. GIC enters the electric utility grid via the grounded transformer neutral and can cause severe saturation to transformers. This in turn causes disruptions to grid synchronisation. The main contribution of this thesis is that effects of GIC are studied using the UMEC transformer model, which can model saturation. The assessment leads to the development of enhanced fundamental positive sequence control (EFPSC) which is capable of reducing the stress on the system during GIC events. The methods developed can also be applied to other non-symmetrical AC events occurring in VSC-HVDC such as single-phase faults. Additional contributions of the thesis are:A mathematical model of the MMC is derived and forms the foundation of the AVM. The AVM is verified against a detailed equivalent-circuit-based model and shows good accuracy. The PLL is the essential component for grid synchronisation of VSC-HVDC system. Different PLLs are studied in detail. Their performance is compared both qualitatively and quantitatively. This appears to have been done for the first time systematically in the public literature. The UMEC model is verified using hand calculation. Its saturation characteristic is matched to a predefined B-H curve and is also verified. The verifications show that this model is capable of modelling transformer saturation and thus is suitable for this study. The consolidation of the AVM, PLL, UMEC, GIC and EFPSC provides an insight into the how the MMC based VSC-HVDC system behaves under severe geomagnetic disturbances and the possible methods to mitigate the risks and impacts to the power grid.

The doctoral thesis proposes a synchronization event detection method suitable for establishing a common time base across devices using power-line communication. The technique facilitates the creation of a synchronization procedure for smart grid terminal devices, thus bringing to the low-voltage segment new functionalities already known from the higher voltage levels of the distribution network. High-precision, zero-cross line voltage detection was employed as the synchronization event. The use of the PLL (phase-locked loop) was considered and analyzed as a potentially applicable option; however, such a solution proved to be insufficiently robust against interference. Further, an FFT-based approach was designed and reviewed. The technique performs zero-cross detection, but only for the fundamental harmonic component that remains the same across the entire network. The influence of incoherent sampling on the FFT, too, was tested during the development of the method; in this context, coherent sampling was found to constitute an essential prerequisite for accurate detection as it allows us to eliminate the spectral leakage error. The impact of an AD converter on the detection accuracy was also evaluated. The proposed approach ensures the accuracy required for all common measurements and operations to improve the production, distribution, and consumption of electricity through smart grids.

The Small Aircraft Transportation System (SATS) is a partnership between the FAA, the NASA, US aviation companies, universities and state and local aviation officials. The purpose of SATS is to develop a system to handle future increase in Air Traffic, reduce time-travel, develop automation in Air Traffic Control (ATC) and make better use of small aircraft and underused airports. The Smart Landing Facility (SLF) is an important part of the program. The SLF is a small airport upgraded with equipment to support SATS aircraft. Among the SLF equipment, SATS needs new detection equipment, and eventually automation. This thesis investigates different techniques to avoid data collision in aircraft radar responses, and to reduce delays between landings and take offs. First, the paper shows how and when the radar receiver can separate two overlapped radar responses. Second, to avoid transponders responses overlapping, requirements in terms of aircraft safety distance are computed, different conflicts in air traffic around the SLF are examined and a solution is proposed for each case. And finally, the thesis investigates how far SATS can go in developing an automatic ATC system and what the role of future human operator will be in ATC. / Master of Science

Incomplete biological concepts in lymphoid neoplasms still dictate to a large extent the limited availability of efficient targeted treatments, which entertains the mostly unsatisfactory clinical outcomes. Aberrant expression of the embryonal and lymphatic TCL1 family of oncogenes, i.e., the paradigmatic TCL1A, but also TML1 or MTCP1, is causally implicated in T- and B-lymphocyte transformation. TCL1A also carries prognostic information in these particular T-cell and B-cell tumors. More recently, the TCL1A oncogene has been observed also in epithelial tumors as part of oncofetal stemness signatures. Although the concepts on the modes of TCL1A dysregulation in lymphatic neoplasms and solid tumors are still incomplete, there are recent advances in defining the mechanisms of its (de)regulation. This review presents a comprehensive overview of TCL1A expression in tumors and the current understanding of its (dys)regulation via genomic aberrations, epigenetic modifications, or deregulation of TCL1A-targeting micro RNAs. We also summarize triggers that act through such transcriptional and translational regulation, i.e., altered signals by the tumor microenvironment. A refined mechanistic understanding of these modes of dysregulations together with improved concepts of TCL1A-associated malignant transformation can benefit future approaches to specifically interfere in TCL1A-initiated or -driven tumorigenesis.

T-cell prolymphocytic leukemia (T-PLL) is the most common mature T-cell leukemia. It is a typically aggressively growing and chemotherapy-resistant malignancy with a poor prognosis. T-PLL cells resemble activated, post-thymic T-lymphocytes with memorytype effector functions. Constitutive transcriptional activation of genes of the T-cell leukemia 1 (TCL1) family based on genomic inversions/translocations is recognized as a key event in T-PLL’s pathogenesis. TCL1’s multiple effector pathways include the enhancement of T-cell receptor (TCR) signals. New molecular dependencies around responses to DNA damage, including repair and apoptosis regulation, as well as alterations of cytokine and non-TCR activation signaling were identified as perturbed hallmark pathways within the past years. We currently witness these vulnerabilities to be interrogated in first pre-clinical concepts and initial clinical testing in relapsed/refractory TPLL patients. We summarize here the current knowledge on the molecular understanding of T-PLL’s pathobiology and critically assess the true translational progress around this to help appraisal by caregivers and patients. Overall, the contemporary concepts on T-PLL’s pathobiology are condensed in a comprehensive mechanistic disease model and promising interventional strategies derived from it are highlighted.

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No description available.

Advances in transistor-integration technology and multi-core technology of the latest microprocessors have driven transient requirements to become more and more stringent. Rather than relying on the bulky output capacitors as energy-storage devices, increasing the control bandwidth (BW) of the multiphase voltage regulator (VR) is a more cost-effective and space-saving approach. However, it is found that the stability margin of current-mode control in high-BW design is very sensitive to operating conditions and component tolerance, depending on the performance of the current-sensing techniques, modulation schemes, and interleaving approaches. The primary objective of this dissertation is to investigate an advanced multiphase current-mode control, which provides accurate current sensing, enhances the stability margin in high-BW design, and adaptively compensates the parameter variations. Firstly, an equivalent circuit model for generic current-mode controls using DCR current sensing is developed to analyze the impact of component tolerance in high-BW design. Then, the existing state-of-the-art auto-tuning method used to improve current-sensing accuracy is reviewed, and the deficiency of using this method in a multiphase VR is identified. After that, enlightened by the proposed model, a novel auto-tuning method is proposed. This novel method features better tuning performance, noise-insensitivity, and simpler implementation than the state-of-the-art method. Secondly, the current state-of-the-art adaptive current-mode control based on constant-frequency PWM is reviewed, and its inability to maintain adequate stability margin in high-BW design is recognized. Therefore, a new external ramp compensation technique is proposed to keep the stability margin insensitive to the operating conditions and component tolerance, so the proposed high-BW constant-frequency control can meet the transient requirement without the presence of bulky output capacitors. The control scheme is generic and can be used in various kinds of constant-frequency controls, such as peak-current-mode, valley-current-mode, and average-current-mode configurations. Thirdly, an interleaving technique incorporating an adaptive PLL loop is presented, which enables the variable-frequency control to push the BW higher than proposed constant-frequency control, and avoids the beat-frequency input ripple. A generic small-signal model of the PLL loop is derived to investigate the stability issue caused by the parameter variations. Then, based on the proposed model, a simple adaptive control is developed to allow the BW of the PLL loop to be anchored at the highest phase margin. The adaptive PLL structure is applicable to different types of variable-frequency control, including constant on-time control and ramp pulse modulation. Fourthly, a hybrid interleaving structure is explored to simplify the implementation of the adaptive PLL structure in an application with more phases. It combines the adaptive PLL loop with a pulse-distribution technique to take the advantage of the high-BW design and fast transient response without adding a burden to the controller implementation. As a conclusion, based on the proposed analytical models, effective control concepts, systematic optimization strategies, viable implementations are fully investigated for high-BW current-mode control using different modulation techniques. Moreover, all the modeling results and the system performance are verified through simulation with a practical output filter model and an advanced mixed-signal experimental platform based on the latest MHz VR design on the laptop motherboard. In consequence, the multiphase VRs in future computation systems can be scalable easier with proposed multiphase configurations, increase the system reliability with proposed adaptive loop compensation, and minimize the total system footprint of the VR with the superior transient performance. / Ph. D.

This thesis applies the concept of a virtual-synchronous-machine- (VSM-) based control to a conventional 250-kW utility-scale photovoltaic (PV) inverter. VSM is a recently-developed control scheme which offers an alternative grid-synchronization method to the conventional grid-tracking control scheme, which is based on the dq phase-locked-loop- (PLL-) oriented vector control. Synchronous machines inherently synchronize to the grid and largely partake in the stabilization of the grid frequency during power system dynamics. The purpose of this thesis is primarily to present the design of a grid-forming control scheme based on the VSM and the derivation of the terminal dq-frame ac impedance of the small-signal model of the inverter and control scheme. This design is also compared to the design of the conventional grid-tracking control structure, both from a loop design and terminal dq-frame ac impedance standpoint. Due to the inherent lax power-balance synchronization, the grid-forming control scheme results in 1 to 2 decades' lower frequency range of negative incremental input impedance in the diagonal elements, which is a favorable condition for stability. Additionally, the stability of the grid-forming control scheme is compared to the conventional grid-tracking control using the generalized Nyquist criterion (GNC) for stability under three modes of operation of active and reactive power injection. It is found that the connection is stable for both control schemes under unity power factor and fixed reactive power modes; however, the grid-forming control is able to inject twice the amount of active power under the voltage regulation mode when compared to the grid-tracking control. / Master of Science / Concerns about the current and future state of the environment has prompted government and non-profit agencies to enact regulatory legislation on fossil fuel emissions. In 2017, electricity generation comprised 28% of total U.S. greenhouse gas emissions with 68% of this generation being due to coal combustion sources. As a result, utilities have retired a number of coal power plants and have employed alternative means of power generation, specifically renewable energy sources (RES). Most RES operate as variable-frequency ac sources (wind) or dc sources (solar) and are interfaced with the power grid through ac-dc-ac or dc-ac converters, respectively, which are power-electronic devices used to control the injection of power to the grid. Conventional converters synchronize with the grid by tracking the phase of the voltage at the point of common coupling (PCC) through a phase-locked loop (PLL). While power system dynamics significantly affect the performance of a PLL, and, subsequently, inverters' operation, the initial frequency regulation during grid events is attributed to the system's inherent inertia due to the multitude of synchronous machines (SM). However, with the steady increase of RES penetration, even while retaining the number of SM units, the net inertia in the system will decrease, thus resulting in prolonged responses in frequency regulation to the aforementioned dynamics. This thesis investigates the control of variable-frequency sources as conventional synchronous machines and provides a detailed design procedure of this control structure for photovoltaic (PV) inverter applications. Additionally, the stability of the connection of the inverter to the grid is analyzed using innovative stability analysis techniques which treat the inverter and control as a black box. In this manner, the inner-workings of the inverter need not be known, especially since it is proprietary information of the manufacturer, and the operator can measure the output response of the device to some input signal. In this work, it is found that the connection between the inverter and grid is stable with this new control scheme and comparable to conventional control structures. Additionally, the control based on synchronous machine characteristics shows improved stability for voltage and frequency regulation, which is key to maintaining a stable grid.

Signal generation at high frequency has become increasingly important in numerous wireline and wireless applications. In many gigahertz and millimeter-wave frequency ranges, conventional frequency generation techniques have encountered several design challenges in terms of frequency tuning range, phase noise, and power consumption. Recently, injection locking has been a popular technique to solve these design challenges for frequency generation. However, the narrow locking range of the injection locking techniques limits their use. Furthermore, they suffer from significant reference spur issues. This dissertation presents novel frequency generation techniques based on envelope detection for low-phase-noise signal generation using injection-locked frequency multipliers (ILFMs). Several calibration techniques using envelope detection are introduced to solve conventional problems in injection locking. The proposed topologies are demonstrated with 0.13um CMOS technology for the following injection-locked frequency generators. First, a mixed-mode injection-frequency locked loop (IFLL) is presented for calibrating locking range and phase noise of an injection-locked oscillator (ILO). The IFLL autonomously tracks the injection frequency by processing the AM modulated envelope signal bearing a frequency difference between injection frequency and ILO free-running frequency in digital feedback. Second, a quadrature injection-locked frequency tripler using third-harmonic phase shifters is proposed. Two capacitively-degenerated differential pairs are utilized for quadrature injection signals, thereby increasing injection-locking range and reducing phase error. Next, an injection-locked clock multiplier using an envelope-based frequency tracking loop is presented for a low phase noise signal and low reference spur. In the proposed technique, an envelope detector constantly monitors the VCO's output waveform distortion caused by frequency difference between the VCO frequency and reference frequency. Therefore, the proposed techniques can compensate for frequency variation of the VCO due to PVT variations. Finally, this dissertation presents a subharmonically injection-locked PLL (SILPLL), which is cascaded with a quadrature ILO. The proposed SILPLL adopts an envelope-detection based injection-timing calibration for synchronous reference pulse injection into a VCO. With one of the largest frequency division ratios (N=80) reported so far, the SILPLL can achieve low RMS jitter and reference spur. / Ph. D. / Signal generation at high frequency has become increasingly important in numerous wireline and wireless applications. In many gigahertz and millimeter-wave frequency ranges, conventional frequency generation techniques have encountered several design challenges in terms of frequency tuning range, phase noise, and power consumption. Recently, injection locking which synchronizes a signal frequency has been a popular technique to solve these design challenges for frequency generation. However, narrow operation ranges of the injection locking techniques limit their use. Furthermore, they suffer from significant noise degradation. This dissertation presents studies of frequency generation techniques based on envelope detection (amplitude modulation) for low-phase-noise signal generation using injection-locked frequency multipliers. Several calibration techniques using envelope detection are introduced to solve conventional problems in injection locking. First, a mixed-mode injection-frequency locked loop is presented for calibrating locking range and phase noise of an injection-locked oscillator. Second, a quadrature injection-locked frequency tripler using third-harmonic phase shifters is proposed to increase injection-locking range and reduce phase error. Third, an injection-locked frequency multiplier using an envelope-based frequency tracking loop is presented for a low phase noise signal and low noise degradation. Finally, this dissertation presents a subharmonically injection-locked PLL with a novel injection-timing calibration circuit, which is connected to a quadrature frequency multiplier. The proposed designs are demonstrated with 0.13µm CMOS technology.