Cette étude cherche à 1) comparer la personnalité et l’adaptation des fibromyalgiques (FM) avec ceux ayant une polyarthrite (PR), une spondylarthrite (SA) ou un syndrome de Gougerot-Sjögren (SG) ; 2) identifier les liens et influences entre la personnalité et les variables agissant sur le retentissement et le coping et 3) observer l’existence de différences intra-groupes chez les FM. 48 FM, 47 PR, 47 SA et 23 SG ont répondu aux BFI (personnalité), GHQ (souffrance psychique), FIQ (douleur, retentissement), FSS (fatigue), EVE (événements de vie), CSQ (coping) et MINI (comorbidité anxio-dépressive). Les FM ont une élévation de l’agréabilité (A), de l’ouverture (O), du Névrosisme (N) et un retentissement plus sévère que les autres. Dans les maladies rhumatismales, l’anxiété influence la dépression, la douleur, la fatigue et la dramatisation. N influence majoritairement l’anxiété, le coping actif et modérément la dépression. Enfin, la douleur et N permettent de distinguer deux sous groupes dans la FM. La personnalité a une influence sur l’adaptation. A et O semblent être des défenses face au stress alors que N a un impact direct et néfaste dans l’adaptation / This study aims to 1) compare personality and adaptation of fibromyalgia patients (FM) with those having a rheumatoid arthritis (PR), a ankylosing spondylitis (SA) or Sjogren’s syndrome (SG); 2) identify the links and the influences between the personality and the variables acting on repercussions of the illness and coping; 3) observe the existence of intra-group differences in FM. 48 FM, 47 PR, 47 SA and 23 SG answered the BFI (personality), GHQ (psychic suffering), FIQ (pain, repercussions of the illness), FSS (fatigue), EVE (events of life), CSQ (coping ) and MINI (anxio depressive comorbidity). The FM show a rise in agreeableness (A), openness (O) and neuroticism (N) and a more severe impact than the other diseases. In the rheumatic diseases, anxiety influences depression, pain, fatigue and dramatization. N influences mainly anxiety, active coping and moderately depression. Finally, pain and N allow to distinguish two groups in FM. Personality has an influence on adaptation. A and O seem to be defenses in the face of stress while N has a direct and worse impact on the adaptation

Made available in DSpace on 2016-06-02T20:30:59Z (GMT). No. of bitstreams: 1 6781.pdf: 1060045 bytes, checksum: 44dd78f66094315ba519c95c465d4469 (MD5) Previous issue date: 2015-03-26 / Financiadora de Estudos e Projetos / Rheumatic diseases have been defined as those relating to musculoskeletal and connective tissues. Through the analysis of the literature it is observed a significant prevalence among patients with these pathologies, and both depression and anxiety. The present study investigated, in two different studies, the relations between rheumatic diseases and mental disorders. The Study 1 presents a literature reviews organized in the form of article. The manuscript presents the product of a literature review in brazilian and foreign databases, in the last 25 years, examining the results on the prevalence of mental disorders in rheumatic diagnoses patients, particularly anxiety and depression. The review was organized to systematize the principal addressed rheumatologic diseases, the countries where the investigations were implemented, the populations investigated in these studies, and the prevalence observed between depression and anxiety in each case. In Study 2 indicators of depression and anxiety in users of rheumatology ambulatory are described, in a health and teaching unit, with exclusive service to users of the Social Health System. It was evaluated 85 patients, 76 women and 9 men, aged between 41 and 70 years. In the evaluation, the following instruments were used: 1) The questionnaire for survey of general information; 2) Beck Depression Inventory (BDI); 3) Beck Anxiety Inventory (BAI); 4) Inventory of Stress Symptoms of Lipp (ISSL); and; 5) Brazilian Economic Criteria of the ABEP. The results showed that 51.8% of the sample had a education equal or less to complete primary, and 31.8% are retired or removed by social security provision. In addition, 68.2% of them were identified as inserted into economic classes with power consumption equal or less than to Class C1; 37,6% of users had two or more diagnosis of rheumatic diseases. Indicators showed that 43.5% of users were under medical treatment with at least one psychotropic substance, with treatment duration ranging from 2 to 21 years. Users under psychotropic drug prescription had significantly higher scores of depression (Mann-Whitney: z = 6.513, p <0.000), anxiety (Mann- Whitney: z = 6.083, p <0.000) and stress (Mann-Whitney: z = 6.119; p <0.000). The rheumatics diseases most frequently found in the population were Fibromyalgia (n = 33), Osteoarthritis (n = 33) and Rheumatoid arthritis (n = 24). In the general population, there was a prevalence of 43.5% of depression, 57% anxiety and 31.4% of stress. Considering the prevalence of depression in the Fibromyalgia, Osteoarthritis and Rheumatoid Arthritis were observed respectively values of 87.9%, 60.6% and 37.5%. Anxiety showed a prevalence of 72.7% in Fibromyalgia, 36.4% in Osteoarthritis, and 29.2% in Rheumatoid Arthritis. It was discussed the importance of evaluation and multidisciplinary intervention, in particular the psychologist role, for the care of rheumatic diseases. / As doenças reumatológicas têm sido definidas como aquelas relativas ao sistema musculoesquelético e tecidos conectivos. Através da análise da literatura observa-se uma prevalência significativa entre indivíduos acometidos por estes quadros, depressão e ansiedade. O presente trabalho investigou a relação entre doenças reumáticas e transtornos mentais em dois diferentes estudos. O Estudo 1 apresenta uma revisão bibliográfica organizada na forma de artigo. O manuscrito apresenta o produto de uma revisão bibliográfica, em bases de dados brasileiras e estrangeiras, nos últimos 25 anos, examinando os resultados referentes à prevalência entre diagnósticos reumatológicos e transtornos mentais, em particular, ansiedade e depressão. O levantamento foi organizado de forma a sistematizar os principais quadros reumatológicos endereçados, os Países onde as investigações foram implementadas, as populações analisadas nestes estudos, além da prevalência observada entre depressão e ansiedade em cada caso. No Estudo 2 é descrita uma avaliação de indicadores de depressão e ansiedade em usuários de ambulatórios de reumatologia, numa Unidade Saúde-Escola de uma instituição de ensino superior, com atendimento exclusivo a usuários do Sistema Único de Saúde (SUS). Foram avaliados 85 usuários, sendo 76 mulheres e 9 homens, com idade variando entre 41 e 70 anos. Na avaliação foram utilizados os seguintes instrumentos: 1) Questionários para levantamento de informações gerais; 2) Inventário Beck de Depressão (BDI); 3) Inventário Beck de Ansiedade (BAI); 4) Inventário de Sintomas de Stress da Lipp (ISSL); e; 5) Critério Econômico Brasil da ABEP. Os resultados evidenciaram que 51,8% da amostra apresentaram uma escolaridade igual ou inferior ao fundamental completo, sendo que 31,8% encontram-se aposentados ou afastados pela previdência. Além disto, 68,2% deles foram identificados como inseridos em classes econômicas com poder de consumo igual ou menor à Classe C1; 37,6% dos usuários apresentavam dois ou mais diagnósticos de doenças reumatológicas. Indicadores apontaram que 43,5% dos usuários estavam sob tratamento medicamentoso com pelo menos uma substância psicotrópica, com tempo de tratamento que variou de 2 a 21 anos. Usuários sob prescrição medicamentosa psicotrópica apresentaram escores significativamente maiores de depressão (Mann-Whitney: z=6,513; p<0,000), ansiedade (Mann-Whitney: z=6,083; p<0,000) e estresse (Mann-Whitney: z=6,119; p<0,000). As doenças com maior frequência na população foram Fibromialgia (n=33), Artrose (n=33) e Artrite Reumatoide (n=24). Na população geral, observouse uma prevalência de 43,5% de depressão, 57,% de ansiedade e 31,4% de estresse. Considerando especificamente a prevalência de depressão, na Fibromialgia, Artrose e Artrite Reumatoide foram observados, respectivamente, os valores de 87,9%, 60,6% e 37,5%. A ansiedade obteve prevalência de 72,7% na Fibromialgia, 36,4% na Artrose, e 29,2% na Artrite Reumatoide. Discute-se a importância da avaliação e intervenção multiprofissional, em particular do psicólogo, para o cuidado das doenças reumatológicas.

京都大学 / 0048 / 新制・論文博士 / 博士(医学) / 乙第12815号 / 論医博第2077号 / 新制||医||1004(附属図書館) / 31302 / 京都大学大学院医学研究科医学専攻 / (主査)教授 山田 亮, 教授 小川 誠司, 教授 竹内 理 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM

Introduktion/Bakgrund: En procent av världens befolkning är drabbade av den kroniska autoimmuna inflammatoriska sjukdomen Reumatoid artrit (RA) som kan orsaka värk, trötthet, stela leder, svullnad och som bidrar till minskad livskvalitet. I dagsläget är den farmakologiska behandlingen en central del av patienternas liv vilket kan bromsa sjukdomsförloppet men inte bota den. Litteraturstudien undersöker hur alternativa behandlingsmetoder upplevs av patienter med RA. Syfte: Syftet var att belysa patienters upplevelser av alternativa behandlingsmetoder vid RA. Metod: Litteraturstudien genomfördes utifrån Polit och Becks (2021) nio steg. Litteratursökningarna gjordes i databaserna Cinahl och PubMed. Tio artiklar var relevanta för litteraturstudiens syfte och granskades med hjälp av granskningsmallar. Resultat: Resultatet baseras på tio vetenskapliga artiklar, sju kvalitativa och två kvantitativa, samt att en artikel hade mixad metod. I sammanställningen framkom två teman: Positiva upplevelser och Negativa upplevelser. Slutsats: Alternativa behandlingsmetoder bidrog till att majoriteten av patienterna upplevde minskad smärta, ångest och depression. De upplevde även att socialt stöd från andra patienter bidrog till positivt välmående samt ökat självförtroende.

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Made available in DSpace on 2016-04-27T13:10:22Z (GMT). No. of bitstreams: 1 Adriano Chiereghin.pdf: 1166167 bytes, checksum: 0846ec244c19a990817fd1b67c5adfdb (MD5) Previous issue date: 2013-08-07 / The study had as main goal to define the professional profile that serves the primary health sector in the city of Sorocaba, and analyze the way in which it is inserted, to identify if there are conditions for the care of rheumatic and low complexity diseases and the possible reasons that would lead to a high degree of referral to specialists. Methods: We performed a quantitative and qualitative study in which doctors from primary health care were invited to answer a questionnaire that addressed personal aspects of professional technicians plus four rheumatic diseases: osteoarthritis, gout, fibromyalgia and osteoporosis which served as the basis for evaluating the care of diseases of low complexity in primary health care. Results: It was observed that the professional is housed in an organizational system that hinders its performance; furthermore, it was noticed certain personal technical difficulties. These conditions combined turn out to be factors that determine a quality of care that falls short of expected. Conclusion: It is necessary that there be a review of how medical education is given in order to seek a more qualified and dedicated training to the basic needs of the health system and a restructuring of the entire health system in terms of organization and management so that there is a suitable condition for the development of a good medical practice and hence provide a fine service to the public / O estudo teve como principal meta definir o perfil do profissional que atende no setor primário de saúde na cidade de Sorocaba, e analisar o meio em que este está inserido, tentando identificar se há condições para o atendimento de doenças reumáticas de baixa complexidade e os possíveis motivos que levariam a um alto grau de encaminhamento aos especialistas. Métodos: Realizamos um estudo quanti-qualitativo no qual médicos da atenção básica de saúde foram convidados a responder à um questionário que abordava aspectos pessoais do profissional, além de técnicos de quatro doenças reumáticas: osteoartrite, gota, fibromialgia e osteoporose as quais serviram de base para avaliar o atendimento a doenças de baixa complexidade nas UBSs. Resultados: Observou-se que o profissional encontra-se inserido num sistema organizacional que dificulta sua atuação; além disso, perceberam-se certas dificuldades pessoais técnicas. Essas condições somadas acabam por serem fatores que determinam uma qualidade de atendimento aquém da esperada. Conclusão: É necessário que haja uma revisão de como a educação médica se dá, a fim de buscar uma formação mais qualificada e voltada às necessidades básicas do sistema de saúde além de uma reestruturação de todo sistema de saúde do ponto de vista de organização e gestão, para que haja uma condição adequada para o desenvolvimento de uma boa prática médica e, consequentemente, uma boa prestação de serviço à população

Diss. (sammanfattning) Uppsala : Uppsala universitet, 2007. / Härtill 5 uppsatser.

Chronische Schmerzerkrankungen beeinflussen die Arbeitsfähigkeit deutlich. Ziel dieser systematischen Übersichtsarbeit ist es, arbeitsbezogene Studienendpunkte in randomisierten, placebokontrollierten Studien zu chronischen Schmerzerkrankungen und schmerzhaften rheumatologischen Erkrankungen zu analysieren. Datenbanktreffer einer Literaturrecherche in Medline (Pubmed) wurden als Abstracts gesichtet und potentiell relevante Studien danach im Volltext beurteilt. Die methodologische Studienqualität wurde mit der Oxford Quality Scale (OQS) bewertet. Verfügbare arbeitsbezogene und schmerzbezogene Endpunkte wurden in Meta-Analysen mit Hilfe von einem „fixed effect model“ oder einem „random effects model“ zusammengefasst. Lineare Regressionen zwischen arbeitsbezogenen Endpunkten und schmerzbezogenen Endpunkten wurden durchgeführt. Insgesamt 31 Publikationen mit einer Gesamtzahl von 11434 Patienten berichten über arbeitsbezogene Studienendpunkte; dies waren nur ungefähr 0,23% aller relevanten Publikationen. Eine Meta-Analyse aller arbeitsbezogenen Endpunkte, ohne Unterteilung nach vorgenommener Behandlung und der spezifischen vorliegenden Erkrankung, konnte einen allgemeinen Behandlungserfolg von 0,35, ausgedrückt als standardisierte Mittelwertsdifferenz (SMD), mit einem 95%-Konfidenzintervall (95%-KI) von 0,21 bis 0,50 beschreiben. Eine umfassende Meta-Analyse der Schmerzendpunkte derselben Studien ergab eine allgemeine Verbesserung bezüglich schmerzbezogener Endpunkte von 0,40, ausgedrückt als SMD (95%-KI: 0,25; 0,55). Weitere Meta-Analysen zeigten statistisch signifikante Verbesserungen in den Behandlungsgruppen für die folgenden Parameter: Beeinträchtigungen bei der Arbeit (0,62 Punkte auf einer 0- bis 10-Punkte-Skala; 95%-KI: 0,45; 0,79), Arbeitsproduktivität (SMD 0,53; 95%-KI: 0,18; 0,88), 30%ige Schmerzverbesserung relativ zu Studienbeginn (ausgedrückt als Verbesserung des relativen Risikos (RR) von 33%; 95%-KI: 15%; 53%) und 50%ige Schmerzverbesserung relativ zu Studienbeginn (RR 46%; 95%-KI: 22%; 74%), 20%iges (RR 184%; 95%-KI: 86%; 334%), 50%iges (RR 237%; 95%-KI: 84%; 715%) und 70%iges (RR 232%; 95%-KI: 65%; 571%) Ansprechen der Patienten bezogen auf die Kriterien des „American College of Rheumatology“ (ACR). Ergebnisse Arbeitsfehlzeiten und Beschäftigungsverhältnisse betreffend waren heterogen und nicht aussagekräftig. Lineare Regressionensanalysen von sowohl kontinuierlichen arbeitsbezogenen mit kontinuierlichen schmerzbezogenen Endpunkten, als auch von kontinuierlichen arbeitsbezogenen Endpunkten mit kategorischen schmerzbezogenen Ansprechraten, belegten einen statistisch signifikanten Zusammenhang. Abschließend kann berichtet werden, dass arbeitsbezogene Endpunkte nur sehr selten in placebokontrollierten Studien zu chronischen Schmerzerkrankungen untersucht wurden, und dass, wenn sie berichtet wurden, die Endpunkte und Berichterstattung heterogen waren. Es konnten wiederholt statistisch signifikante Behandlungseffekte für verschiedene arbeitsbezogene Endpunkte nachgewiesen werden. Weiterhin konnte gezeigt werden, dass eine starke lineare Relation zwischen arbeitsbezogenen Endpunkten und schmerzbezogenen Endpunkten vorliegt.

Hensikt: Å kartlegge hvilken kunnskap norske pasienter med ankyloserende spondylitt har om sykdommen og i hvilken grad deres tiltro til egen mestringsevne påvirker deres helserelaterte livskvalitet.Metode: Tverrsnittstudie i form av en spørreundersøkelse for å kartlegge og beskrive deltagernes kunnskap om sykdommen og hvordan denne kunnskapen påvirker deres livssituasjon. Studien ble gjennomført på 150 pasienter i forbindelse med deres deltagelse på en behandlingsreise til utlandet.Resultat: Pasientene var mest fornøyde med den informasjonen de fikk fra spesialist i revmatologi og fysioterapeut. De anga også medpasienter som en viktig kilde til informasjon. Deltagelse i mestringskurs og informasjon fra sykepleier var de informasjonskildene færrest respondenter var fornøyde med. Respondentene hadde mest kunnskap om sykdommens symptomer og trening, mens kunnskap om medikamenter og hjelpemidler/tiltak for tilrettelegging hjemme og på arbeidsplassen var de temaer de hadde minst kunnskap om. De som var mest fornøyde med den kunnskapen de hadde om sykdommen, hadde en signifikant bedre tiltro til at de kunne påvirke sine smerter og sykdomssymptomer.Konklusjon: Kunnskap om sykdommen bidrar positivt til å påvirke pasientenes helserelaterte livskvalitet. Læring gjennom utveksling av kunnskap og erfaringer med andre i samme situasjon, synes å være en riktig og positiv måte å tilrettelegge pasientundervisningen på. Målgruppen bør imidlertid kartlegges, slik at undervisningen kan tilpasses deltagernes utdannelsesnivå. Likeledes bør helsepersonellets roller og funksjoner avklares og tydelig defineres. / Aims: This study sought to explore the knowledge Norwegian patients with ankylosing spondylitishave about the disease and to what extent belief in their own capacity to master the disease affectshealth-related quality of life.Methods: We used questionnaires to explore and describe participants’ knowledge about ankylosingspondylitis. The questionnaires also assessed how this knowledge affected participants’ lifesituations. The study included 150 patients who participated in a rehabilitation programme abroad.Results: The patients were most satisfied with information provided by rheumatologists andphysiotherapists. They also considered fellow patients as an important source of information. Lesssatisfactory was information provided by nurses and courses in disease mastery. Respondents werevery knowledgeable about disease symptoms and physical exercise. However, they described theirknowledge about medication and appliances designed for use at home or in the workplace as limited.The patients who were most satisfied with their knowledge about the disease had a significantlybetter belief in their ability to cope with pain and disease-related symptoms.Conclusions: Knowledge about their disease contributed positively to patients’ health-related qualityof life. Sharing knowledge and personal experience with others who are in similar situationsenhances learning and appears to be a useful and positive way of providing patient education.However, adapting training to the educational background of participants will require carefulassessment of the target group. Similarly, the roles and domains of health care professionals requireclear definitio / <p>ISBN 978-91-85721-82-5</p>

Trotz aller Fortschritte bei der Etablierung spezifischer Autoantikörperassays ist das Screening auf antinukleäre Antikörper (ANA) mittels indirekter Immunfluoreszenz an HEp-2-Zellen für eine qualitätsgerechte Labordiagnostik von ANA-assoziierten rheumatischen Erkrankungen (AARE) weiterhin unabdingbar. Mit den Erkenntnissen zur Relevanz von DFS-Mustern und DFS70-Antikörpern eröffnen sich neue Möglichkeiten zur Optimierung der serologischen Stufendiagnostik bei Verdacht auf AARE. Das dicht-feingranuläre („dense fine speckled“, DFS) ANA-Muster ist relativ gut von den klassischen, mit dsDNAAntikörpern assoziierten „homogenen“ ANA-Mustern differenzierbar. Die wichtigste bei diesem Muster nachweisbare ANA-Spezifität ist der DFS70-Antikörper (Synonym: LEDGFAntikörper). Dieser Antikörper ist auch die häufigste bei ANA-positiven gesunden Personen nachweisbare ANA-Spezifität. Die Prävalenz von DFS70-Antikörpern in AARE-Patienten ist signifikant niedriger im Vergleich zur Prävalenz bei ANA gesunden Personen. Es besteht eine negative Assoziation der DFS70-Antikörper mit AARE, insbesondere wenn der Antikörper nicht in Begleitung von klinisch relevanten Autoantikörpern vorliegt. Isolierte DFS70-Antikörper findet man in weniger als 1% der AARE, aber in 5%–11% bei gesunden Personen. Beim Vorliegen eines isolierten DFS70-Antikörpers verringert sich die post-Test-Wahrscheinlichkeit für eine AARE deutlich. DFS70-Antikörper sind daher wertvolle neue Biomarker zur besseren Interpretation positiver ANA bei Negativität für AARE-assoziierte Autoantikörper und sollten in modifizierte Testalgorithmen zur Vermeidung unnötiger Überweisungen und Folgeuntersuchung von ANA positiven Personen integriert werden.