Orientador: Edi Lucia Sartorato, Marilia Fontenele e Silva Camara / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia / Made available in DSpace on 2018-08-12T09:52:30Z (GMT). No. of bitstreams: 1 Andrade_PaulaBaloni_M.pdf: 7604209 bytes, checksum: 7ff181694c7d80ca5f7d2d27b1fc272d (MD5) Previous issue date: 2008 / Resumo: A perda auditiva em recém-nascidos de alto risco, varia de 20-40 em cada 1000 nascimentos. Em uma porcentagem variável de casos, a etiologia é ambiental, decorrente de fatores pré, peri ou pós-natais ou pode ainda ser de origem genética. O principal objetivo deste projeto foi determinar a etiologia da perda auditiva em crianças admitidas em unidades de terapia intensivas neonatais (UTIN) e avaliar a contribuição de outros fatores, principalmente medicamentos ototóxicos. Assim, foram selecionados 4 grupos: 25 crianças nascidas prematuras, de UTIN e com perda auditiva (grupo A), 25 crianças nascidas prematuras, de UTIN e sem perda auditiva (grupo B), 25 crianças nascidas a termo e com perda auditiva (grupo C) e 25 crianças nascidas a termo sem perda auditiva (grupo D), onde foram estudadas as principais mutações que levam à perda auditiva neurossensorial não-sindrômica: 35delG (no gene GJB2), mutações mitocondriais A7445G, G7444A (no gene CO1), A1555G, C1494T, A827G, T961G e 961delT/insC (no gene 12S rRNA e, em geral, moduladas pelo uso de antibióticos aminoglicosídeos), deleções ?(GJB6-D13S1830) e ?(GJB6-D13S1854), no gene GJB6. Em casos em que não se encontrou uma mutação que justificasse a perda, o gene GJB2 foi sequenciado. Foram encontrados no grupo A 1 indivíduo com a mutação V37I (gene GJB2) em heterozigose e 2 com a mutação A827G. No grupo B foram encontrados 3 indivíduos com a mutação A827G. No grupo C foram encontrados 5 indivíduos com a mutação A827G e 5 com a mutação 35delG em homozigose. No grupo D foi encontrado apenas 1 indivíduo com a mutação A827G. Estes resultados mostraram que a mutação A827G pode estar sendo modulada por mais de um fator, como aminoglicosídeos ou genes nucleares moduladores. A mutação 35delG parece estar diretamente relacionada a perdas congênitas profundas e pré-linguais. Na comparação dos grupos A e B o Teste de Mann-Whitney mostrou significância na média do período de internação entre eles (p-valor = 0,003), mostrando que esta diferença pode ser a principal causa da perda auditiva no grupo A. E na comparação dos grupos A e C, o Teste de Mood mostrou diferença altamente significativa de perda auditiva de ambas orelhas entre estes grupos (Orelha esquerda: p-valor = 0,002 e Orelha direita: p-valor = 0,000), sendo as perdas no grupo A severas e no grupo C profundas, mostrando que no grupo C esta perda é provavelmente causada por fatores genéticos, que levam a perdas profundas, bilaterais e pré-linguais como mostram estudos prévios feitos com o gene GJB2. No caso de indivíduos com perda auditiva, onde não foram encontradas mutações, há a possibilidade de que esta tenha sido causada por fatores ambientais ou ainda por mutações não pesquisadas neste trabalho. Deste modo, é de extrema importância o rastreamento genético para o diagnóstico precoce, otimizando, assim, as chances de desenvolvimento da fala e linguagem. / Abstract: The frequency of sensorioneural hearing loss in high-risk newborns is 20-40 in 1000 births. In many cases, the cause is environmental, due to prenatal, perinatal and postnatal factors, or caused by genetic factors. The main objectives of this project were to determine the etiology of the hearing loss in children admitted into Neonatal Intensive Care Unit (NICU) and compare with other factors, mainly ototoxic medication. 4 different groups were selected: 25 pre-matures (from NICU) with sensorioneural nonsyndromic hearing loss (group A), 25 pre-matures (from NICU) without hearing loss (group B); 25 full term children with sensorioneural nonsyndromic hearing loss (group C) and 25 full term children without hearing loss (group D). The main mutations which cause hearing loss were studied: 35delG (GJB2 gene), A7445G, G7444A (CO1 mitochondrial gene), A1555G, C1494T, A827G, T961G and 961delT/insC (in the 12S rRNA mitochondrial gene and, in general, modulated by aminoglycosides), ?(GJB6-D13S1830) and ?(GJB6-D13S1854) (in the GJB6 gene). The complete GJB2 gene was sequenced in cases where the 35delG mutation wasn't found, or where it was found in heterozygosis. 1 child was found with V37I in heterozygosis (GJB2 gene) and 2 with the A827G mutation in group A. 3 children were found with the A827G mutation in group B. 5 children were found with the A827G mutation and 5 others with 35delG in homozygosis in group C. In group D only 1 child was found with the mutation A827G. These results show that A827G mutations might be modulated by more than one factor, like aminoglycosides or nuclear modifier genes. The 35delG mutation might be directly related to prelingual profound congenit losses. Comparing groups A and B, Mann- Whitney's Test showed significant results in the NICU period average (p-value = 0,003), indicating that this diference could be the major cause of hearing loss in group A. The Mood Test showed highly significant hearing loss diference in both ears between groups A and C (left ear p-value = 0,002 and right ear p-value = 0,000), showing severe loss in group A and profound loss in group C, indicating that in group C this loss is probably caused by genetic factors that induce prelingual bilateral profound loss, as related in previous GJB2 studies. In cases of hearing loss where mutations couldn't be found, it is possible that it has been caused by other mutations not studied or environmental causes. Therefore, the screening of mutations is important because it could provide better chances of developing speech and language. / Mestrado / Genetica Animal e Evolução / Mestre em Genética e Biologia Molecular

Orientador: Paulo Correa Lima / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecanica / Made available in DSpace on 2018-08-04T03:13:38Z (GMT). No. of bitstreams: 1 Marcondes_AndrezaBenatti_M.pdf: 5495313 bytes, checksum: a5a7651ef5e80d1a06695be92059dd0b (MD5) Previous issue date: 2003 / Resumo: As mudanças nos padrões de competitividade da indústria brasileira influenciaram os procedimentos na avaliação de investimentos em capital fixo das empresas. Neste sentido, a decisão de investir em determinado projeto não é baseada somente na relação entre uma taxa interna de retomo e uma taxa mínima de atratividade, mas deve-se levar em consideração fatores como tempo de resposta ao cliente, qualidade e custo. Para alcançar estes requisitos, a empresa deve reconfigurar seu processo de negócios e uma das áreas mais afetadas é o chão-de-fábrica. A abordagem da Toyota Motor Corporation para projeto de sistemas de manufatura, conhecida como manufatura enxuta, mostrou ser capaz de garantir resultados superiores. Os modelos de análise de investimento atuais, criados para atender a produção em massa, falham em apontar os resultados gerados pela produção enxuta. Este trabalho pretende entender o impacto financeiro de se converter uma fábrica do sistema de produção em massa para o sistema enxuto. Um caso de estudo de uma montadora que se tornou referência nas práticas enxutas é utilizado para verificar se ocorreram transformações na metodologia utilizada pela empresa / Abstract: The changes in the competitiveness standards in the Brazilian industry had influenced on the investment evaluation procedure of fixed capital in corporations. In this way, the decision to invest in a project must not be only based on a relation between the internal rate of return and attractiveness rate. It is necessary to consider factors as response time to customers orders, quality and cost. In order to achieve those requirements most companies need to reconfigure their business process and one of the most affected areas in the shop floor. Toyota Motor Corporation' s approach to manufacturing system design, a1so known as lean manufacturing, has been showing superior performance. The current investment ana1ysis models, created to support mass production, :fail in recognize the effectiveness of lean manufacturing. This work aims at understanding financial impact of restructuring a plant from mass to lean production. A case study of an automotive assembly company who become a benchmark on lean practices is used to check of investments methodologies had been reviewed to support manufacturing transformation / Mestrado / Materiais e Processos de Fabricação / Mestre em Engenharia Mecânica

The main goal of this Master´s Thesis is to analyze the risks of quality management in manufacturing branch of BTL zdravotnická technika, a.s. The introduction part is summarization of important terms from the field of management quality, risk management and metrology. Analysis of the current risk management is a part of the practical part of this Master´s Thesis. The key part of this Thesis is identification of risks in the metrology field and their analysis. For the analysis was used FMEA methodology. The outcome is a register of risk which is valuable for this Thesis as well as for the company. Suggestion for improvements for the critical risks are introduces at the end of this Thesis.

An Application Service Provider (ASP) is a company that offers individuals or enterprises access over the Internet to applications and related services that would otherwise have to be located in their own personal or enterprise computers. The simplest way to understand the ASP concept is to think of it as "application-renting". However, the customer always owns the data. The primary purpose of this thesis is to see what kind of demands there is on an ASP solution from the customers? side. The secondary purpose is to see if the customers could consider an ASP solution if their demands were met. We have also given an explanation of the ASP concept and what factors, within the data security context, makes the solution acceptable among customers. The method we have used to find a result to our hypothesis and research questions, is that we have collected different text materials and conducted interviews. The interviewed companies where four ASP suppliers and four future possible ASP customers. The result of our investigation showed that a majority of the interviewed persons could consider an ASP solution. The result could however not be estimated and applied for the entire company, because of the variety of knowledge between the different departments. The ASP industry is clearly in the stage of maturity within the IT business, but it seems like the psychological barrier may be the strongest factor that can diminish the success of ASP.

Quality and security of software are key factors in the software development. This thesis deals with the quality of open source software (OSS for short) and different questions that are related with open source and close source software has discussed in the thesis proposal. Open source software is a process by which we can produce cheap and qualitative software and its source could be re-use in the development of the software. Close source software is more expensive than open source software and we can not re-use its source code, so there should be a way by which cheap and qualitative software should be produced. This thesis describes that how the quality of the open source software can be evaluated and increased. There are different factors which are helpful to increase the software quality these factors are low cycle time, low cost and small size of software. These factors are also helpful for the development of software product according to the requirement of clients and the users of that software. This thesis also describes the security and performance of close and open source software and it also analyze different software development processes. The quality of OSS can be increased by use of best evaluation techniques, best quality measurement, best development tools and best development process. There are also many challenges for OSS, which it has to face for improvement of the quality of OSS. Initially there were many drawbacks in open source software but with the passage of time improvement has produced in it. This thesis also describes the compression, advantages and disadvantages of the close source and open source software. / 0046-737218653 , 0046-739131829

Obesity is presently one of the leading preventable causes of mortality and is an increasing issue that affects the workplace. This pilot study investigates the effects of a multidisciplinary obesity management program on employees within a community hospital setting. The purpose of this study is to assess the outcome factors of the intervention and to detect an association between the participants’ biological factors, psychological status, eating behaviors, and lifestyle components to that of their current body weight status. Methods. An evaluation of a tailored obesity management program was conducted in a corporate setting with employees of a large community hospital. The evaluation sought to determine if this program could be efficiently and effectively implemented in this corporate setting. This program also allowed an exploration of those sociological, biological, and behavioral factors that were associated with weight loss. An employee health outcomes assessment visit was used to identify, recruit and enroll overweight employees into a quasi-experimental study designed to evaluate potential impacts of a tailored weight management program. The 6-month intervention included medical assessments, nutritional coaching, activity counseling, and behavioral therapy. The following specific aims were proposed for this dissertation research: Specific Aim 1 sought to evaluate the effectiveness of the multidisciplinary weight loss program to change a series of modifiable health risk factors, body composition, clinical indicators, and biological markers from baseline to 6 months for overweight participants. Specific Aim 2 evaluated factors associated with achieving weight loss and patterns of attrition from the program. Weight and lifestyle factors included onset of obesity, family history, weight loss history, weight loss goals, self-perceptions, physical activity factors, and eating habits/patterns. Within Specific Aim 3, we determined if body composition measurements [body mass index (BMI), weight, basal metabolic rate, fat mass, percent fat, fat free mass, and total body water] correlated with standing or supine measurements of waist, hip, or thigh circumferences. We also investigated if there was a significant difference between recording measurements made in both positions. This aim sought to determine if both sets of position measurements needed to be included for subsequent weight management studies. Results. Forty-six (46) employees, with a mean age of 48.6 +/- 10.9 years and predominately female (91.3%), consented to participate in the pilot intervention, with 26 participants completing the 6 months (response = 50.9%). Statistically significant changes from baseline were seen at 6 months in the 44 participants that continued in the study after enrollment. In the intent to treat analysis, the participants, regardless of completion status, had a clinically significant (p<.0001) mean percent weight loss of 4.1% and a total weight loss of 9.3 pounds, with a corresponding 5.6% mean weight loss in those participants that completed the program. When analyzing predictors of attrition from the program, models indicated significant associations between overall program attrition and an increase in baseline systolic blood pressure (p=0.02), along with decreased compliance with eating three meals per day (p=0.04). Primary attrition (dropout < 3 months) was statistically associated with an increase in baseline systolic blood pressure (p=0.02) and decreased compliance with eating three meals per day (p=0.01). Secondary attrition (dropout between 3-6 months) was associated with decreased compliance with eating three meals per day (p=0.05) and an increase in weight loss expectations during the intervention (p=0.05). The mean absolute difference between the two techniques (standing vs. supine) was 4.14 inches for waist, hip, and thigh measurements combined. An increase in body mass index was associated with a greater magnitude of discrepancy in the measurement between the two techniques for waist circumference (p=0.02). Conclusions. The changes seen following this multidisciplinary intervention were clinically significant and advantageous for the participants. These substantial results suggest that the use of multidisciplinary weight management programs merits further investigation in larger, randomized, controlled trials.

The construction industry is in third place concerning the number of yearly accidents and in secondplace concerning accidents with deadly outcomes in Sweden according to statistics (Arbetsmiljöverket2017a). This is an issue that Skanska, NCC, PEAB, Sveriges Byggindustrier and Byggnads isdetermined to work on to improve. A work procedure to identify and address safety risks during theplanning- and projection phase of a construction project has been developed with support from SBUF(Holm, Lidgren, Montecinos 2013). The work procedure is designed to first identify the safety risksthat is present for the current project with the help from a checklist. Then if the risks can’t beeliminated in the projection phase the risk will be highlighted on the construction drawings. A problemthat was discovered during the implementation of the work procedure in a construction project wasthat too many and not relevant risks was highlighted on the construction drawings. The purpose ofthis report is to produce underlying instructions to the planners of the construction project so thatthey can make use of the work procedure in the most appropriate manner. This report is written bystudents from Högskolan I Halmstad in co-operation with Skanska Teknik in Gothenburg. This reportis limited to new office and housing construction projects.To produce a result, we have conducted two comprehensive interviews as well as surveys answered byproduction managers. These interviews and surveys led to the conclusion that for the work procedureto succeed it’s important to have a good composition in the group that will work together with thechecklist and the identification of safety risks. The group is recommended to be composed of planners,project managers, safety representatives and if possible experienced workers. Another important aspectto make the work procedure successful is to make the checklist reflect the conditions of theconstruction projects that are being processed. Two construction project is almost never the sameconditions which doesn’t lend itself well to making a work procedure that handles all different casesof projects. The results also reveal that construction engineers and planners lack knowledge andeducation concerning work environment on construction sites. The results we have produced will alsohelp planners of construction projects that will use this specific work procedure to know which of thesafety risks are relevant to be highlighted on the construction drawings. We have also proposed someareas that needs more researched to make the work procedure more complete. / Byggbranschen ligger på tredje plats i statistiken över mest olyckor per år och på andra plats gällandeolyckor med dödlig utgång i Sverige (Arbetsmiljöverket 2017a). Detta är något som Skanska, NCC,PEAB, Sveriges Byggindustrier och Byggnads anser måste förbättras. Ett arbetssätt för att identifieraoch projektera bort risker under projekteringen av ett byggprojekt togs fram i samarbete med SBUF(Holm, Lidgren, Montecinos 2013).Arbetssättet går ut på att identifiera säkerhetsrisker med hjälp av en checklista, för att sedan markeraut identifierade risker på arbetsritningarna. Ett problem som upptäcktes när arbetssättetimplementerades i projekt var att det var oväsentliga och för många risker som markerades ut påritningarna. Syftet med rapporten är att ta fram ett underlag till projektörer så de kan användaarbetssättet på bästa sätt. Rapporten skrivs på Högskolan i Halmstad i samarbete med Skanska Tekniki Göteborg. Rapporten är avgränsad mot nybyggnation av kontor och bostäder.För att få fram resultatet har det genomförts två omfattande intervjuer samt enkäter medproduktionschefer. Dessa intervjuer och enkäter resulterade i slutsatsen att det är viktigt att ha en brasammansättning på gruppen som ska arbeta med checklistan samt att identifiera säkerhetsriskerna. Detär bra om gruppen har en samansättning på både projektörer, projektledare ochskyddsombud/yrkesarbetare för att komplettera varandra. Det visade sig också att det var viktigt attgöra checklistan projektspecifik. Inget byggprojekt är det andra likt och därför behöver checklistanriktas mot just det projekt som ska genomföras. Det framkommer även i resultaten att projektörerbehöver mer utbildning gällande arbetsmiljö och arbetet i byggproduktionen ute på byggarbetsplatsen.Resultaten kommer att kunna underlätta för projektörer att kunna veta vilka risker som ska sättasut/inte sättas ut på ritningar. Det har även uppkommit fler områden att undersöka djupare för att fåett ännu mer komplett arbetssätt.

Context: Cloud Outsourcing is a new form of outsourcing which is not more under implementation and yet to be implemented. It is a form of outsourcing in which software organizations outsource the work to e-freelancers available throughout the world using cloud services via the Internet. Software organizations handovers the respective task to the cloud and from the cloud e-freelancers undertake the development of task and then return back the finished task to the cloud. Organizations recollect the finished task from the cloud and verify it and then pay to the e-freelancer. Objectives: The aim of this study is to identify the sequence of activities involved during the entire process of cloud outsourcing and to find out the risks which are likely to be occurred during the implementation of this process. To prioritize the elicitated risks according to their probability of occurrence, impact and cost required to mitigate the corresponding risk. Methods: Data is collected by literature review and then the data is synthesized. On the other side interviews with practitioners are conducted to know the activities involved and to find out the risks that are likely to be occurred during the implementation of cloud outsourcing. After this, a survey is conducted in order to prioritize the risks and a standard risk analysis is conducted to know the risks which are likely to be occurred. Literature review is done using four databases including the literature from the year 1990 to till date. Results: Totally we have identified 21 risks that are likely to be occurred and 8 activities so far. By performing risk analysis we have presented the risks, which should be considered first and relevant counter measures are suggested to overcome them. / mr.kommineni@me.com, mr.kommineni1@gmail.com phone no. +919963420123

When a new product should be acquired, a model over its functionality is made. A quite new idea in the military area is to use simulations to find out what and how much to acquire. Since the product never has been on the market before it is hard to know how factors in the surroundings, like weather and other active objects, will affect it. Therefore these unknown factors that appear during the creation or acquiring of a new product need to be taken into consideration. A literature study is performed about how modelling of simulations can be done, and how unknown factors can be considered when modelling a simulation. The study goes into if unknown factors are taken into consideration when modelling in the Process component in Simulation Based Acquisition (SBA). The result of this study shows that SBA facilitates in the process of finding and reducing unknown factors.

The concept of outsourcing is a hot topic even today. The area of IT has received more attention when compared to other areas of outsourcing. Many organizations started outsourcing IT functions to other countries to access international markets. There lie many risks that are overlooked by these organizations. These risks need to be properly assessed and managed. This research investigates the potential risks perceived to be most relevant in the process of IT outsourcing from the customers point of view and how organizations can eliminate these risks by providing measures to assess risks. Literature analysis is the methodology used for conducting this research as it is assumed to cover all aspects of risks that lie in global IT outsourcing process.