In patients with Parkinson’s disease (PD), the molecularly misfolded form of α-synuclein was recently identified in cutaneous autonomic nerve fibers which displayed increased accumulation even in early disease stages. However, the underlying mechanisms of synucleinopathic nerve damage and its implication for brain pathology in later life remain to be elucidated. To date, specific diagnostic tools to evaluate small fiber pathology and to discriminate neurodegenerative proteinopathies are rare. Recently, research has indicated that deposition of α-synuclein in cutaneous nerve fibers quantified via immunohistochemistry in superficial skin biopsies might be a valid marker of PD which could facilitate early diagnosis and monitoring of disease progression. However, lack of standardization of techniques to quantify neural α-synuclein deposition limits their utility in clinical practice. Additional challenges include the identification of potential distinct morphological patterns of intraneural α-synuclein deposition among synucleinopathies to facilitate diagnostic discrimination and determining the degree to which structural damage relates to dysfunction of nerve fibers targeted by α-synuclein. Answering these questions might improve our understanding of the pathophysiological role of small fiber neuropathy in Parkinson’s disease, help identify new treatment targets, and facilitate assessment of response to neuroprotective treatment.

This diploma thesis attempts to improve the language-support for coping with the problem of negative emergence in dynamic Systems-of-Systems (SoS). Negative emergence is understood to be the emergence of unintended behaviour among constituent systems of a SoS in response to certain changes to the composition of constituent systems in the SoS. The architecture description language (ADL) "EventArch 2.0" approaches this problem by allowing the SoS-manager to define certain rules to manipulate the original behaviour of certain constituent systems at certain critical points of execution of the SoS to prevent unintended behaviour ("coordination rules"). This thesis approaches a solution to the following problem: to prevent the introduction of unintended behaviour through overly- or underly-restrictive coordination rules, more- or less-restrictive variants of a coordination rule would have to be applied to the SoS depending on the current composition of constituent systems in the SoS. This thesis has the goal to approach this problem by devising a mechanism to dynamically exchange a coordination rule depending on the current composition of constituent systems in the SoS. To achieve that goal, the ADL "EventArch 2.0" is extended to support the dynamic application of a coordination rule to a System-of-Systems. The dynamic application is achieved by connecting coordinators and constituent systems at runtime. As a special characteristic, each coordinator is dedicated to a specific constituent system and is responsible for achieving compliance of that system with respect to a specific coordination rule. It is shown that this architectural setup can be nicely modeled using concepts from the field of "role-based modeling". The solution does therefore employ concepts that are central to the "role-based modeling"-approach: "Role", "Base", and "Compartment". The applicability of the extended language to practical coordination-problems is shown by applying it to a constructed use case in the field of energy-efficient computing.:1 Introduction 1 1.1 Motivation and Problem Statement 1 1.2 Overview 2 2 Background 4 2.1 System of Systems 4 2.2 EventArch 2.0 8 2.2.1 Concepts 8 2.2.2 Implementation 10 2.2.3 Diagrams 15 2.3 Role-based Modeling 19 2.4 Coupling Strategies 22 3 Related Work 25 3.1 Requirements 25 3.2 Features 28 3.3 OT/J 29 3.4 Other Role-based Languages 31 3.5 Areas of Improvement 35 3.5.1 OT/J 35 3.5.2 Other Role-based Languages 40 4 Concepts of EventArch 3.0 45 4.1 Base, Role, and Compartment 45 4.2 Dynamic Composite AEM and Role-Binder 46 4.3 Inner Roles and Atomic Block 48 4.4 Diagrams 49 5 Internal Design of EventArch 3.0 55 5.1 Implementation of the Concepts 55 5.1.1 Base, Role, and Compartment 56 5.1.2 Dynamic Composite AEM and Role-Binder 58 5.1.3 Inner Roles and Atomic Block 60 5.1.4 Other Concepts 62 5.2 Further Discussion and Design Alternatives 63 6 Evaluation of EventArch 3.0 66 6.1 Advantages 66 6.2 Disadvantages 74 6.3 Reflections on the Fulfillment of the Requirements 77 6.4 Use case 81 6.5 Application to the Example Use case 83 6.5.1 Presentation of the implementation 83 6.5.2 Advantages shown by the implementation 90 7 Conclusion 93 7.1 Future Work 95 8 Appendix 99 8.1 Additional Source-Code 99 8.1.1 OT/J source-code 99 8.1.2 “State”-coordination rule 105 8.2 Internal Design of EventArch 2.0 109 8.2.1 Abstract 109 8.2.2 Detailed 116 8.3 Grammar of EventArch 3.0 . 123 8.4 EventArch 3.0 Diagrams 126 Bibliography 134 / Die vorliegende Diplomarbeit ist mit der Verbesserung der Sprachunterstützung zur Vermeidung negativer Emergenz in dynamischen Systems-of-Systems (SoS) befasst. Negative Emergenz wird dabei als unerwünschtes Verhalten von an einem SoS beteiligten Systemen verstanden, welches auf Grund von Änderungen in der Zusammensetzung des SoS (d.h. auf Grund des Eintritts oder Austritts von konstituierenden Systemen) aufgetreten ist. Die Architekturbeschreibungssprache "EventArch 2.0" unterstützt den SoS-manager bei der Lösung dieses Problems durch die Möglichkeit das Verhalten der beteiligten Systeme in bestimmten Ausführungsmomenten durch die Definition von Koordinationsregeln zu manipulieren und auf diesem Wege das Auftreten negativer Emergenz zu vermeiden. Die Diplomarbeit ist ein Beitrag zur Lösung des folgenden Problems: Um die Einführung von unerwünschtem Verhalten durch übermäßig- oder unzureichend restriktive Koordinationsregeln zu verhindern, müssten unterschiedliche Varianten einer Koordinationsregel, die sich im Grade ihrer Restriktivität unterscheiden, auf das SoS angewendet werden. Diese Anwendung müßte in Abhängigkeit der aktuellen Zusammensetzung des SoS aus konstituierenden Systemen erfolgen. In der vorliegenden Diplomarbeit wird eine Möglichkeit entwickelt um eine Koordinationsregel zur Laufzeit in Abhängigkeit der aktuellen Zusammensetzung des SoS aus konstituierenden Systemen auszutauschen. Sie leistet damit einen Beitrag zur Lösung des vorgenannten Problems. In der Arbeit wird die Architekturbeschreibungssprache "EventArch 2.0" um die Möglichkeit des dynamischen Austausches von Koordinationsregeln erweitert. Dabei werden Koordinationsregeln angewendet durch die gezielte Verbindung von Koordinatoren und konstituierenden Systemen. Die Besonderheit des Ansatzes besteht darin, dass jedem konstituierenden System ein persönlicher Koordinator zugeordnet wird, d.h. ein Koordinator der ausschließlich für die Anpassung des Verhaltens des jeweiligen Systems an eine bestimmte Koordinationsregel verantwortlich ist. In der Arbeit wird gezeigt, dass dieser architektonische Ansatz durch zentrale Konzepte des Modellierungsansatzes "rollenbasierte Modellierung" modelliert werden kann. In der entwickelten Spracherweiterung werden daher die Konzepte "Rolle", "Basis" und "Compartment" verwendet. Die Anwendbarkeit der erweiterten Sprache, wird durch deren Anwendung auf einen konstruierten Anwendungsfall aus dem Bereich der Energie-effizienten Berechnung gezeigt.:1 Introduction 1 1.1 Motivation and Problem Statement 1 1.2 Overview 2 2 Background 4 2.1 System of Systems 4 2.2 EventArch 2.0 8 2.2.1 Concepts 8 2.2.2 Implementation 10 2.2.3 Diagrams 15 2.3 Role-based Modeling 19 2.4 Coupling Strategies 22 3 Related Work 25 3.1 Requirements 25 3.2 Features 28 3.3 OT/J 29 3.4 Other Role-based Languages 31 3.5 Areas of Improvement 35 3.5.1 OT/J 35 3.5.2 Other Role-based Languages 40 4 Concepts of EventArch 3.0 45 4.1 Base, Role, and Compartment 45 4.2 Dynamic Composite AEM and Role-Binder 46 4.3 Inner Roles and Atomic Block 48 4.4 Diagrams 49 5 Internal Design of EventArch 3.0 55 5.1 Implementation of the Concepts 55 5.1.1 Base, Role, and Compartment 56 5.1.2 Dynamic Composite AEM and Role-Binder 58 5.1.3 Inner Roles and Atomic Block 60 5.1.4 Other Concepts 62 5.2 Further Discussion and Design Alternatives 63 6 Evaluation of EventArch 3.0 66 6.1 Advantages 66 6.2 Disadvantages 74 6.3 Reflections on the Fulfillment of the Requirements 77 6.4 Use case 81 6.5 Application to the Example Use case 83 6.5.1 Presentation of the implementation 83 6.5.2 Advantages shown by the implementation 90 7 Conclusion 93 7.1 Future Work 95 8 Appendix 99 8.1 Additional Source-Code 99 8.1.1 OT/J source-code 99 8.1.2 “State”-coordination rule 105 8.2 Internal Design of EventArch 2.0 109 8.2.1 Abstract 109 8.2.2 Detailed 116 8.3 Grammar of EventArch 3.0 . 123 8.4 EventArch 3.0 Diagrams 126 Bibliography 134

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Den här uppsatsen avser undersöka hur Försvarsmaktens roll inom den civila krisberedskapen uppfattas av de civila aktörerna som ingår i krisberedskapsorganisationen (kommuner, landsting, bevakningsansvariga myndigheter, samt länsstyrelser) samt vilken formell roll Försvarsmakten ska spela, utifrån hur myndigheten styrts politiskt genom undersökning av Försvarsbeslutet 2015 samt efterföljande regleringsbrev och direktiv, under perioden 2015 - 2017. Uppsatsen avser endast undersöka Försvarsmaktens stöd till civila (icke-beväpnade) insatser, och således är ex. stöd till Polisen i samband med terrorismbekämpning inte undersökt. / This bachelor thesis examines the role of the Swedish Armed Forces (SAF) in civilian crisis management. The Swedish crisis management system is based upon the principle of responsibility (Ansvarsprincipen), which means that an actor responsible for a certain function of society during a normal state also is responsible for maintaining this function during disturbance or crisis. This gives each actor a clear role to plays in times of crisis. The SAF has no clear peacetime role within the frame of national defense except for maintaining readiness to face an armed assault or violation of Swedish territory by foreign powers. The SAF is also supposed to give support to other parts of society when needed, but this support is to be given within already existing abilities and resources. The task is also non-dimensional, which means the SAF is not expected to organize itself primarily for this task.  The analysis will focus only on the role of the SAF, and not on the roles of other actors within civilian crisis management, and only on unarmed operations. A consequence of this demarcation is that the SAF's role within anti-terrorist operations will be left out. Demarcation in time is the period of 2015 - 2017.

Bei der Umsetzung moderner Managementkonzepte wie bspw. Supply Chain Management, Customer Relationship Management und Partner Relationship Management werden Anwendungssysteme wertschöpfungskettenübergreifend eingesetzt. Das bedeutet, dass sowohl interne als auch externe Benutzer auf verschiedene Anwendungssysteme eines Unternehmens zugreifen. Die daraus resultierenden Anforderungen werden als Paradigma des homogenen Enterprise Access Managements (hEAM) beschrieben. Zur Umsetzung dieser Anforderungen wird ein Referenzmodell zur anwendungssystemübergreifend konsistenten Zugriffssteuerung (MAKS) entwickelt. Eine entsprechende Realisierungsmöglichkeit in Form eines zentralen Rollen- und Rechtemanagementsystems (ZR2MS) ergibt sich aus der Referenzarchitektur zur anwendungssystemübergreifend konsistenten Zugriffssteuerung (A2KS).

Although public relations is seen as a function that contributes to the greater good of society and the performance of an organisation (ref. Grunig, 2006b:3; Grunig, Grunig & Dozier, 2002:xii), the function does not, for various reasons, always deliver on this promise (ref. Gray, 2004:26–27; Grunig et al., 2002:166, 169, 192; Steyn, 2000c:40; Tobin, 2004:56; Van Ruler, 1997:248, 263; 2004a:123). Practitioners and professional bodies from various countries have researched, and tried to overcome the variables negatively influencing practitioners, through various methods. However, no study has provided a comprehensive prioritised list of all the variables influencing practitioners' contribution to organisational performance. In addition none of these actions has led to a sustainable solution for the profession where a critical mass of practitioners can keep the promise of contributing to the greater good of society and the performance of the organisation. In light of this problem, this study tries to understand how public relations practitioners can enhance their contribution to organisational performance, by examining the variables influencing practitioners in contributing to organisational performance. The study is framed within the relational, reflective, two–way symmetrical and feminist paradigms, supported by the general excellence theory as meta–theory, and the relationship management and corporate communication role theories. The multidimensional paradigm was specifically selected to accommodate the complex research context (Grunig, 1989:18; 2006a; Valin, 2004). From theory it was established that public relations contributes to organisational performance by assisting organisations to adapt to their changing environment by providing strategic information from the environment to the organisation that could reduce uncertainty in the organisation's strategic decision–making (Grunig et al., 2002:xi; Raupp & Van Ruler, 2006:18; Steyn, 2000c:27; Valin, 2004). Through this process the organisation's triple bottom line goals are aligned with the realities of the environment in which it operates (Moss et al., 2000:283; van Tonder & van Rheede van Oudtshoorn, 2006:149). This then creates long–term relationships with stakeholders that creates many benefits for the organisation (Grunig, 2006b:3, 6; Grunig et al., 2002:xi, 10, 11; Grunig & Haung, 2000:32; Hon & Grunig, 1999:7–9, 11; Phillips, 2006a:34, 35; 2006b:212). Within South Africa specifically, corporate communication practitioners perform the roles of strategist, manager and technician in order to complete the above tasks (Steyn, 2000b:1–42; 2000c:20–43). The research methodology followed to gather data to answer the General research question, is both exploratory and interpretive. The research started with a literature study, followed by semi–structured interviews with four purposefully selected practitioners and the chairpersons of the two professional bodies (PRISA and IABC) in order to verify the variables identified in literature, and possibly identify new variables pertaining to the South African environment. These variables, together with those identified in literature, were then used to construct a questionnaire completed by public relations practitioners active in the 1 319 top performing South African organisations as per South Africa's Top 300 National Companies List (Fletcher, 2007:1–330) and the Financial Mail Top 200 Companies List (Williams, 2005:1–168). A response rate of 19.9% was achieved. The qualitative data was content analysed and the quantitative data analysed by means of Statistica (StatSoft Inc., 2007) and SPSS (SPSS Inc., 2007) data analysis software. In order to determine the relationships between the variables influencing practitioners, structural equation modelling, by means of AMOS (SPSS Inc., 2009) software, was used. In essence it was found that practitioners should take ownership and manage the variables influencing their performance. Furthermore, 13 variables pertaining to the individual–, industry– and professional–levels were statistically verified as the most important variables influencing practitioners. Due to the specific relationship between these variables, it would seem that enhancing any of these 13 variables would enhance the practitioner's contribution to organisational performance. The main contribution of the study is to add to the discussion on the how the profession can manage its contribution to organisational performance by categorising and empirically verifying a list of all variables influencing practitioners' performance and by suggesting a model indicating the relationship between the most important variables influencing practitioners. / Thesis (Ph.D. (Communication Studies))--North-West University, Potchefstroom Campus, 2011.

Although public relations is seen as a function that contributes to the greater good of society and the performance of an organisation (ref. Grunig, 2006b:3; Grunig, Grunig & Dozier, 2002:xii), the function does not, for various reasons, always deliver on this promise (ref. Gray, 2004:26–27; Grunig et al., 2002:166, 169, 192; Steyn, 2000c:40; Tobin, 2004:56; Van Ruler, 1997:248, 263; 2004a:123). Practitioners and professional bodies from various countries have researched, and tried to overcome the variables negatively influencing practitioners, through various methods. However, no study has provided a comprehensive prioritised list of all the variables influencing practitioners' contribution to organisational performance. In addition none of these actions has led to a sustainable solution for the profession where a critical mass of practitioners can keep the promise of contributing to the greater good of society and the performance of the organisation. In light of this problem, this study tries to understand how public relations practitioners can enhance their contribution to organisational performance, by examining the variables influencing practitioners in contributing to organisational performance. The study is framed within the relational, reflective, two–way symmetrical and feminist paradigms, supported by the general excellence theory as meta–theory, and the relationship management and corporate communication role theories. The multidimensional paradigm was specifically selected to accommodate the complex research context (Grunig, 1989:18; 2006a; Valin, 2004). From theory it was established that public relations contributes to organisational performance by assisting organisations to adapt to their changing environment by providing strategic information from the environment to the organisation that could reduce uncertainty in the organisation's strategic decision–making (Grunig et al., 2002:xi; Raupp & Van Ruler, 2006:18; Steyn, 2000c:27; Valin, 2004). Through this process the organisation's triple bottom line goals are aligned with the realities of the environment in which it operates (Moss et al., 2000:283; van Tonder & van Rheede van Oudtshoorn, 2006:149). This then creates long–term relationships with stakeholders that creates many benefits for the organisation (Grunig, 2006b:3, 6; Grunig et al., 2002:xi, 10, 11; Grunig & Haung, 2000:32; Hon & Grunig, 1999:7–9, 11; Phillips, 2006a:34, 35; 2006b:212). Within South Africa specifically, corporate communication practitioners perform the roles of strategist, manager and technician in order to complete the above tasks (Steyn, 2000b:1–42; 2000c:20–43). The research methodology followed to gather data to answer the General research question, is both exploratory and interpretive. The research started with a literature study, followed by semi–structured interviews with four purposefully selected practitioners and the chairpersons of the two professional bodies (PRISA and IABC) in order to verify the variables identified in literature, and possibly identify new variables pertaining to the South African environment. These variables, together with those identified in literature, were then used to construct a questionnaire completed by public relations practitioners active in the 1 319 top performing South African organisations as per South Africa's Top 300 National Companies List (Fletcher, 2007:1–330) and the Financial Mail Top 200 Companies List (Williams, 2005:1–168). A response rate of 19.9% was achieved. The qualitative data was content analysed and the quantitative data analysed by means of Statistica (StatSoft Inc., 2007) and SPSS (SPSS Inc., 2007) data analysis software. In order to determine the relationships between the variables influencing practitioners, structural equation modelling, by means of AMOS (SPSS Inc., 2009) software, was used. In essence it was found that practitioners should take ownership and manage the variables influencing their performance. Furthermore, 13 variables pertaining to the individual–, industry– and professional–levels were statistically verified as the most important variables influencing practitioners. Due to the specific relationship between these variables, it would seem that enhancing any of these 13 variables would enhance the practitioner's contribution to organisational performance. The main contribution of the study is to add to the discussion on the how the profession can manage its contribution to organisational performance by categorising and empirically verifying a list of all variables influencing practitioners' performance and by suggesting a model indicating the relationship between the most important variables influencing practitioners. / Thesis (Ph.D. (Communication Studies))--North-West University, Potchefstroom Campus, 2011.

Educators strive to improve student learning outcomes and there are numerous theories suggesting how this is best achieved. However, application of these theories to the coal face of a classroom is often fraught with obstacles resulting in poor outcomes. Constraints imposed by educational policy, school systems, structures and the individual students themselves, realistically require adaptation of theoretical techniques if genuine learning is to be imparted to students. This paper discusses some of the issues surrounding the practical implementation of new methodologies into the classroom and identifies important factors that affect teenagers in their learning of mathematics. Working within the constraints, constantly confronted with obstacles, can be frustrating and demoralising. This paper reflects on twenty years of classroom teaching of mathematics to students with relatively poor socio-economic backgrounds and the lessons learnt from them that may assist teachers to remain enthusiastic and creative with the energy to truly improve mathematics education. Key issues explored in the paper include: ‘Realities of a teacher’s working day’, ‘The learning of mathematics within a government secondary system’, and ‘What can be done to ensure mathematical learning takes place?’

No description available.

Dieser Beitrag spannt einen Bogen von der totalen Entmündigung und Entwürdigung der Frauen im 17./18.Jahrhundert, dargelegt u.a. an Auszügen der Chronik Knobloch Radeberg, bis hin zu ihren Emanzipationsbestrebungen in die Neuzeit. Es ist die Geschichte der Frauenbewegung, Kampf um Gleichberechtigung, denn die Welt, so wie sie eingerichtet war, konnte den Frauen wirklich nicht gefallen, eine Welt der Angst und totalen Unmündigkeit. Angst vor den Strafen Gottes, von den Kanzeln der Kirchen verkündet, Angst vor der Apokalypse und dem Jüngsten Gericht, Angst vor der Obrigkeit und ihren Gerichten. Mit Angst und Verdummung des Volkes ließ es sich schon immer wunderbar regieren.