Around 30,000 people in Sweden suffer stroke every year, out of which about 12,000 end up with language difficulties, aphasia. Behind every person with aphasia there are significant others whose lives are also affected. Studies of how aphasia affects the health of these people are few. The overall aim of the present study was to examine how significant others of people with aphasia perceive their life situation, and how their quality of life is affected by the illness of their partner. Spouses of people with aphasia were contacted through aphasia groups and the Swedish Aphasia Association. A total of eleven people participated in the study, which consisted of the health survey SF-36 and semi-structured interviews. The results indicated that men, working people, and people at retirement age are at risk of having a lower health-related quality of life, by living with a person suffering from aphasia. Other factors that seemed to contribute to a lower quality of life were; a more severe aphasia, a big work load at home, less mutual activities as a couple, and a general decrease of communication in everyday life. The conclusion is therefore, that the health-related quality of life is at risk of becoming negatively affected by living with a person who suffers from aphasia. / Varje år insjuknar cirka 30 000 personer i stroke i Sverige och av dem drabbas cirka 12 000 av språkliga svårigheter i form av afasi. Bakom varje person med afasi finns det anhöriga, vars liv också påverkas. Hur afasin påverkar den anhöriges hälsa är inte väl studerat. Det övergripande syftet med föreliggande studie var därmed att undersöka hur anhöriga, till personer med afasi, uppfattar sin egen livssituation, samt hur deras livskvalitet påverkas av den närståendes sjukdom. Partner till personer med afasi kontaktades genom afasigrupper och afasiföreningar. Totalt valde elva personer att deltaga i studien, vilken bestod av hälsoenkäten SF-36 samt en semistrukturerad intervju. Resultaten pekade på att män, yrkesverksamma och personer i pensionsålder riskerar att få en lägre hälsorelaterad livskvalitet av att leva med någon med afasi. Övriga faktorer, som tycktes bidra till en lägre livskvalitet, var en svårare afasi, en hög börda i hemmet, färre gemensamma aktiviteter som par samt en generell försämring av kommunikationen i vardagen. Slutsatsen är därmed att den hälsorelaterade livskvaliteten riskerar att påverkas negativt av att leva med en person som drabbats av afasi.

Darbo tikslas. Įvertinti sergančiųjų reumatoidiniu artritu darbingo amžiaus žmonių gyvenimo kokybės sąsajas su sveikatos paslaugų prieinamumu Prienų rajone. Uždaviniai. Įvertinti sergančiųjų reumatoidiniu artritu darbingo amžiaus žmonių klinikinę charakteristiką ir sąsajas su socialiniais – ekonominiais veiksniais. Ištirti sergančiųjų reumatoidiniu artritu darbingo amžiaus žmonių savarankiško judėjimo ir apsitarnavimo galimybes. Įvertinti sergančiųjų reumatoidiniu artritu darbingo amžiaus žmonių gydymo įstaigos pasiekiamumo ir aptarnavimo galimybes. Įvertinti sergančiųjų reumatoidiniu artritu gyvenimo kokybės ir skausmo intensyvumo sąsajas su aptarnavimu ir sveikatos priežiūros paslaugų prieinamumo galimybėmis. Tyrimo metodika. Kiekybinis momentinis tyrimas. Anketinė apklausa, naudota SF – 36, DAS 28 ir paruoštas bendrojo pobūdžio klausimynas. Analizuojamosios imties dydis – 67 reumatoidiniu artritu sergantys asmenys. Atsako dažnis – 74,4 proc. Gautiems duomenims apdoroti naudota SPSS 22.0. Rezultatai. Tyrime dalyvavo 61,2 proc. moterų ir 38,8 proc. vyrų. Patenkinamai savo sveikatos būklę dažniau vertino dirbantys respondentai, gyvenantys santuokoje, kaime. Nustatyta, kad sąnarių skausmas dažnai vargina 50,7 proc. respondentų, sąnarių sutinimas – 40,3 proc. tiriamųjų, rytinis sąnarių sustingimas – 34,3 proc. apklaustųjų, sąnarių judesių ribotumas – 52,2 proc. Nedirbantys, gaunantys mažas pajamas respondentai dažniau teigė turintys daugiau sutinusių ir skausmingų sąnarių... [toliau žr. visą tekstą] / Aim of the study. To evaluate the quality of life and its links with accessibility to healthcare services for working age patients with rheumatoid arthritis in Prienai region. Objectives. To evaluate the clinical characteristics and their links to the social - economic factors for working age patients with rheumatoid arthritis. To analize the self-movement and the self-service capabilities for working age patients with rheumatoid arthritis. To evaluate the reach of medical institutions and the service capabilities for working age patients with rheumatoid arthritis. To evaluate the quality of life, the intensity of pain and their links with accessibility to healthcare services for working age patients with rheumatoid arthritis. Methods. Quantitative cross sectional research. The size of the sample under analysis – 67 patients with rheumatoid arthritis. The frequency of the response is 74,4 %. The statistical analysis of data was performed using statistical package SPSS Statistics 22.0. Results. 61,2% women and 38,8% man participated in the study. Working in, living in marriage, living in the village respondents their health evaluated satisfactory more often. The pain of joints more often suffer 50,7% of respondents, the swelling of joints – 40,3%, morning stiffness – 34,3%, limitation of joint movement – 52,2%. The unemployed, with low incomes respondents affirmed about the swollen and the painful joints more often. Respondents living in the village and the employed... [to full text]

This diploma thesis deals with the issue of life quality of patients taking home parenteral nutrition. Its intention is to present the achieved life quality scores in the individual domains of physical and mental health in comparison with general population and to point out the differences in what dimensions the life quality of these patients is particularly affected. The theoretical section describes the present situation of the issue of home parenteral nutrition in the CR and the system of the care about the patients. The chapter about indications and contraindications to HPN is elaborated in more detail. The possibilities of the long-term vascular accesses, the care about them are also mentioned here, and particularly the role of a nurse in patient education in transferring parenteral nutrition to the domestic environment. The problems with long-term parenteral nutrition resulting from mechanic, metabolic and septic complications are also outlined. Parenteral nutrition failure is the most serious problem, which is why a chapter on small intestine transplantation as the last resort to save a patient with combined failure of intestine and nutrition is included. The second part of the theoretical section describes the life quality. I wanted to define the nature of this unambiguously graspable a term, determinants affecting life quality are also mentioned here. The possibilities of life quality measurement and assessment and particularly the follow-up use of the obtained data are mostly summarized here. Goals and hypotheses: Two goals were set to meet the main purpose of the thesis: Goal 1: To find whether the life quality of patients on HPN differs from that of the general public. Goal 2: To find the spheres in which the life quality of patients on HPN is mostly affected. A zero hypothesis was set to achieve the goals: Life quality of patients on HPN does not differ from that of the general public. There is no statistically significant difference between men and women. Eight alternative hypotheses to each life quality domain followed: H1: Patients on HPN show lower life quality score compared to the general public in the sphere of physical functions. H2: Patients on HPN show lower life quality score compared to the general public in the sphere of physical roles' limitation. H3: Patients on HPN show lower life quality score compared to the general public in the sphere of emotional roles' limitation. H4: Patients on HPN show lower life quality score compared to the general public in the sphere of emotional limitation of social functions. H5: Patients on HPN show lower life quality score compared to the general public in the sphere of pain. H6: Patients on HPN show lower life quality score compared to the general public in the sphere of general mental health. H7: Patients on HPN show lower life quality score compared to the general public in the sphere of vitality. H8: Patients on HPN show lower life quality score compared to the general public in the sphere of general health perception. A quantitative method of collected data analysis was applied to the research implementation. The research was based on the standardized questionnaire SF-36 supplemented with questions dealing with identification of respondents, time consumption of their treatment and their consequent satisfaction at the beginning. The questionnaire was distributed to patients using home parenteral nutrition in specialized nutrition centres of the Thomayer Faculty Hospital in Prague, Faculty hospitals in Brno and Hradec Králové and also by electronic means through the website of the citizen association Life without Intestine. The obtained data were statistically evaluated and processed into illustrative tables and graphs.Detailed mapping of the problems of life quality and highlighting of the neglected spheres of life quality of patients using HPN are the outputs of the thesis. The results will be presented to the members of the workgroup for HPN within their.

Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2013-10-16T19:49:06Z No. of bitstreams: 1 Monica Cardozo Rebouças. Resposta a quimioterapia...2012.pdf: 2111449 bytes, checksum: c4c3f7eeb987c9afdfca54d06568dd45 (MD5) / Made available in DSpace on 2013-10-16T19:49:06Z (GMT). No. of bitstreams: 1 Monica Cardozo Rebouças. Resposta a quimioterapia...2012.pdf: 2111449 bytes, checksum: c4c3f7eeb987c9afdfca54d06568dd45 (MD5) Previous issue date: 2012 / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Populações que residem em áreas endêmicas da doença de Chagas são submetidas a múltiplas infecções pelo Trypanosoma cruzi e podem estar infectadas com cepas ou clones com diferentes graus de virulência e susceptibilidade à quimioterapia. Este é um fator importante para o desenvolvimento e morbidade da doença. As cepas de Trypanosoma cruzi representam complexas populações multiclonais, homogêneas ou heterogêneas, com predominância de um clone principal. São biologicamente classificados em Biodemas (Tipos I, II e III) que apresentam diferentes graus de resistência à quimioterapia. Cepas do Tipo I são muito suscetíveis ao tratamento; cepas do Tipo II possuem uma média susceptibilidade (cepa 21SF); cepas de Tipo III são muito resistentes (cepa Colombiana). No presente estudo, é avaliado o resultado do tratamento de camundongos triplamente infectados com clones da cepa 21SF, em comparação com os infectados com a cepa parental. 50 camundongos foram infectados com a cepa 21SF (infecção única). O inóculo foi de 5 x 104 formas tripomastigotas sanguícolas. 80 camundongos foram infectados, sucessivamente, com 3 clones da cepa 21SF (C6, C7 e C8), inóculo: 1x104 formas tripomastigotas (infecção tripla). A infecção simples com cada clone também foi feita. Os camundongos de ambos os grupos foram divididos em dois subgrupos: tratados com Benzonidazol – BZ (100 mg/kg/dia - 60 doses) e controles não tratados. Após 60 dias do final do tratamento, os camundongos sobreviventes foram eutanasiados, por exsanguinação, pós-anestesia; o sangue foi coletado para o exame sorológico de imunofluorescência indireta; testes de cura foram realizados (parasitemia, xenodiagnósticos, hemocultura) e seções do coração e músculo esquelético foram coletadas, fixadas e processadas para o estudo histopatológico em cortes corados com Hematoxilina & Eosina. A PCR foi também usada como uma técnica diagnóstica complementar. Os testes parasitológicos mostraram uma positividade variando de 54,4% nos camundongos infectados com a cepa parental e tratados; 33,4 a 66,7% nos animais com infecção única pelos diversos clones e tratados e 26,7% nos camundongos com infecção tríplice, tratados. Os títulos sorológicos (TIFI) variaram de 1:20 a 1:280 nos infectados com cepa parental tratados com BZ e de 1:640 a 1:1280 para controles não tratados. Os títulos sorológicos na infecção única com cada clone variaram de 1:10 a 1:1280 em camundongos tratados e de 1:160 a 1:1280 nos controles não tratados. A PCR revelou positividade em todos os animais infectados, tratados. O resultado final foi obtido pela combinação dos testes parasitológicos com os títulos sorológicos revelando positividade de 6,6% nos camundongos infectados com a cepa parental e tratados; 0 a 18,2% nos animais com infecção única pelos diversos clones e tratados e 12% nos camundongos com infecção tríplice, tratados. Estudo histopatológico: Os camundongos infectados com a cepa parental apresentaram lesões que variavam de leves a moderadas, na maioria dos casos, predominante no miocárdio (animais tratados e controles não tratados) camundongos submetidos à infecção única por cada clone apresentaram lesões semelhantes aos demonstrados pela infecção com cepa parental. Os camundongos com infecção tripla apresentaram uma exacerbação de lesões, evoluindo para a miocardite crônica. Nestes casos, havia intensas lesões no músculo esquelético; animais tratados apresentaram uma nítida redução das lesões no miocárdio e no músculo esquelético. Os resultados da quimioterapia com Benzonidazol em animais triplamente infectados, considerando os testes parasitológicos e sorológicos, revelaram baixos índices de cura e agravamento das lesões tissulares nos camundongos submetidos a múltiplas infecções com clones obtidos da cepa 21SF. / People living in endemic areas of Chagas disease are submitted to multiple infections during their lives and could be infected with strains or clones with different virulence and susceptibility to chemotherapy. This is an important factor in the development and morbidity of the disease. Strains of Trypanosoma cruzi represent complex multiclonal populations, which can be homogeneous or heterogenous with predominance of a principal clone. The strains are biologically classified in different Biodemes (Types I, II and III) which disclose different degrees of resistance to chemotherapy. Type I strains are very susceptible to treatment; Type II strains disclose medium susceptibility (21SF strain); strains of Type III are very resistant (Colombian strain). The clones isolated from different strains can also present different degrees of resistance. In the present study the results of treatment of mice triple infected with clones of the 21SF strain is evaluated, in comparison with the infected with the parental strain. For the present study, 50 Swiss mice were infected with the 21SF strain (single infection).The inoculum was of 5 x 104 blood trypomastigotes. 80 mice were infected successively with 3 clones of the 21SF strain (C6, C7 and C8) inoculum: 1x104 trypomastigotes (triple infection). Single infection with each Clone was also done. The mice of both groups were divided into 2 sub-groups: treated with Benzonidazol –BZ (100mg/kg/day – 60 doses) and untreated controls. After 60 days of the end of treatment, surviving mice were killed by exsanguinations after anesthesia; the blood was collected for indirect immunofluorescence serological test; cure tests were performed (parasitemia, xenodiagnosis, haemoculture) and sections of the heart and skeletal muscle were collected, fixed and then processed for the histopathological study in sections stained with Hematoxilin end Eosin. PCR reaction was also performed in blood samples as a complementary diagnostic technique. Parasitological tests have shown positive results that varied from 54.4% for the group of mice infected with the parental strain and treated with BZ; 33.4 to 66.7% for the mice with single infection, with each clone, treated with BZ, and 26.7% with triple infection with the three clones, treated with BZ. Serology titers (IIFT) varied from 1:20 a 1:280 for the mice infected with parental strain treated with BZ and from 1:640 to 1:1280 for untreated controls. Serology titers in the single infection with each clone varied from 1:10 to 1:1280 in treated mice and from 1:160 to 1:1280 in the untreated controls. PCR reaction was positive in all the infected mice, treated. Parasitological tests combined with the sorological titers have shown a positivity of 6.6% for the mice infected with the parental strain and treated with BZ; 0 to 18.2% for the mice with single infection with each clone and treated an 12% for the mice with triple infection and treated with BZ. Histopathological examination revealed in mice infected with the parental strain, mild to moderate inflammatory lesions. Mice submitted to single infection with clones of the 21SF strain presented similar lesions to those determined by infection with parental strain. Mice with triple infection present an intensification of lesions, and evolution to a chronic myocarditis and intense lesions in skeletal muscle; Treated animals presented clear reduction of lesions in myocardium and in skeletal muscle. Results of chemotherapy with BZ in mice with triple infection with clones of the 21 SF T. cruzi strain, considering the results of parasitological and serological tests, revealed low cure rates and aggravation of tissue lesions in those animals submitted to triple infections with clones of the parental strain.

Made available in DSpace on 2016-06-02T20:18:07Z (GMT). No. of bitstreams: 1 TeseMTN.pdf: 1356245 bytes, checksum: 4692923c85348f190f2e10d0be464f6e (MD5) Previous issue date: 2007-02-02 / Financiadora de Estudos e Projetos / The aim this study was to investigate the quality of life among postmenopausal women with and without osteoporosis, sudden or not hip fracture, contribute to better understand about influence of the osteoporosis, hip fracture and institutionalization of the quality of life of the women with osteoporosis. Two studies were carried. The first, to investigate the health-related quality of life (HRQoL) of the post-menopausal women with or without osteoporosis through of the SF-36 and OPAQ questionnaire. Two groups were formed, with 21 volunteers each: Group 1 with women without osteoporosis (64,38 ± 4,24 years); and Group 2 with osteoporotic women (67,81 ± 4,19 years). The components Role Physical and General Health showed significant difference (p <0,05) between the groups, with better score to women without osteoporosis. No other differences were found in the SF-36 questionnaire. In the others 6 components, the values showed by two groups do not were significant difference. This form to conclude that post-menopausal women with osteoporosis and physical active can have a quality of life similar to the postmenopausal women without osteoporosis. In the second study, To investigate the health-related quality of life (HRQoL) of the post-menopausal women with osteoporosis, with or without hip fracture, were formed four groups: Group 1: 16 women without hip fracture and sedentary (67,80 ± 3,93 years); Group 2: 20 women without hip fracture and physical active (67,75 ± 4,29 years); Group 3: 20 women with hip fracture and non-institutionalized (70,65 ± 4,53 years); Group 4: 20 women with hip fracture and institutionalized (77,55 ± 6,8 years). The Results showed that the HRQoL of the post-menopausal women with hip fracture and institutionalized is, in general form, worst than non-institutionalized women with osteoporosis physical active, suggest hip fracture in post-menopausal women with osteoporosis to challenge a deteribration in the health-related quality of life, and the institutionalized of the sudden attack to able to contribute for greater decadence of the quality of life. The results of the ours study showed is possible have a good health-related quality of life after osteoporosis diagnostic, principal don t have hip fractures / Este trabalho teve como objetivo comparar a qualidade de vida de mulheres pós-menopausa com e sem osteoporose, acometidas ou não por fratura proximal de quadril, contribuindo assim para um melhor entendimento sobre a influência da osteoporose, fratura de quadril e institucionalização na percepção da qualidade de vida relacionada à saúde. Foram realizados dois estudos. O primeiro comparou a qualidade de vida relacionada à saúde por meio da aplicação do questionário genérico SF-36 (Medical Outcomes Study 36 Item Short-Form Health Survey) em voluntárias com e sem osteoporose. Foram comparados dois grupos, com 21 voluntárias cada, sendo o Grupo 1 constituído por mulheres sem osteoporose (64,38 ± 4,24 anos); e o Grupo 2 constituído por mulheres com osteoporose (67,81± 4,19 anos). Os componentes Aspectos Físicos e Estado geral da Saúde apresentaram diferenças significativas (p <0,05) entre os grupos, com score melhor para as mulheres sem osteoporose. Nos outros seis componentes, os valores apresentados pelos grupos não foram diferentes significativamente.Desta forma, conclui-se que mulheres pós-menopausa acometidas por osteoporose, mas que praticam atividade física podem ter qualidade de vida semelhante ao de mulheres pós-menopausa sem osteoporose. No segundo estudo, com o objetivo de comparar a qualidade de vida relacionada à saúde de mulheres pósmenopausa com osteoporose, acometidas ou não por fratura de quadril, 76 mulheres pós-menopausa com osteoporose responderam aos questionários SF-36 e ao OPAQ (OSTEOPOROSIS ASSESMENT QUESTIONNAIRE). As comparações foram feitas entre quatro grupos: Grupo 1, 16 mulheres sem fratura de quadril e sedentárias (67,80 ± 3,93 anos); Grupo 2, 20 mulheres sem fratura de quadril e praticantes de atividade física (67,75 ± 4,29 anos); Grupo 3, 20 mulheres com fratura de quadril e não institucionalizadas (70,65 ± 4,53 anos); Grupo 4, 20 mulheres com fratura de quadril e institucionalizadas (77,55 ± 6,8 anos). Os resultados mostram que a Qualidade de Vida relacionada à Saúde de mulheres pós-menopausa acometidas por fraturas de quadril e que residem em instituições é, de modo geral, pior do que a de portadoras de osteoporose que convivem na comunidade e que praticam atividade física, sugerindo que a fratura de quadril em mulheres pós-menopausa acometidas por osteoporose, provoca uma piora na qualidade de vida relacionada à saúde, sendo que a institucionalização dos acometidos pode colaborar para um declínio ainda maior da qualidade de vida. Os resultados de ambos estudos mostram que é possível ter uma boa percepção da Qualidade de Vida relacionada à Saúde mesmo após o diagnóstico de osteoporose, principalmente se for fisicamente ativo e não ter fraturas de quadril

This dissertation concerning the theme "A comparison of the Contact and HRQOL concept in clients of nursing/old people´s homes" consists of a theoretical and practical part. The theoretical part firstly defines in detail the concept of the quality of life and the quality of life related to health (HRQoL ? health related quality of life). It also describes various methods of its evaluation. The next charter deals with the problems of aging and changes which arise with increasing age and are associated with a deteriorating health condition, as well as with situations and circumstances which may reset in a chase in the perception of the quality of life. The dissertation takes a closer look at the stay of elderly in some institutions for the elderly. The theoretical part compares the results obtained from elderly clients in an old people?s home using standardised SF-36 and Contact questionnaires. The SF-36 questionnaire is designed to measure the quality of life related to health and the Contact questionnaire serves to ascertain the frequency of contact between family and friends ant he elderly client. Data from both questionnaires were evaluated statistically and drawn up in the form of tables and graphs. This research showed a reduced perception of the quality of life of clients living in old people?s homes compared with the standard European population. In most domains of the quality of life there was no significant difference between clients with various frequency of contact with family and friends, and no difference was found n the evaluation of the quality of life between men and women.

A multiple cerebrospinal sclerosis is one of the most frequent neurologic diseases affecting individuals in the productive age, more often women. The thesis aims to describe the life quality of patients suffering from multiple sclerosis. To detect whether due to the multiple sclerosis the qualities of life change. If this would be the case then the goal is to reveal which aspects the changes affect. Another objective was to establish whether the life quality of multiple sclerosis patients decreases depending on the period of time since the diagnosis was made, that is on the duration of the disease. The theoretical part of the thesis is dedicated to describing the disease in general, signs, symptoms, prognosis, and treatment. I also deal with defining the term of life quality and its clarification, I also discuss the social-legal problems of the disease. The practical part of the thesis implements both qualitative and quantitative methods. The qualitative method included a semi-standardized interview. The quantitative method incorporated interrogative research using a SF-36 questionnaire about the quality of life conditioned by health. The information detected from the semi-standardized interview (the qualitative part) served as the basis for defining hypotheses for the quantitative part of the thesis. The following hypotheses were defined: H1: ``The quality of life in patients diagnosed with multiple sclerosis is lower than in the general population" and H2: "The quality of life in multiple sclerosis carriers decreases in correlation to the period of time since the diagnosis was made, that is on the duration of the disease.{\crqq} Chapter ``Results{\crqq} contains the established information.

nÃo hà / A matemÃtica à uma ciÃncia repleta de significados, tambÃm no cotidiano. As prÃticas culturais podem e devem ser utilizadas no ensino dessa disciplina. Entretanto, a inter-relaÃÃo matemÃtica e cultura ainda nÃo à uma realidade nas escolas pÃblicas, pois, na maioria dos casos, o principal recurso pedagÃgico à o livro didÃtico e a apresentaÃÃo dos conteÃdos se dà de forma hierarquizada, ensinando primeiro os conteÃdos mais fÃceis que servirÃo de prÃ-requisito para a aprendizagem de conteÃdos mais complexos. Objetivamos com esse estudo analisar o processo de aprendizagem de uma turma de alunos do 9. ano do ensino fundamental dos anos finais, especialmente sobre os conceitos matemÃticos que envolvem simetria e isometria a partir de Atividades DidÃticas (AD) que relacionam as rendas de bilros e a matemÃtica cultural elaboradas por Santos (2012). O estudo à de natureza qualitativa, do tipo indutivo, com fins exploratÃrios, visando a aproximaÃÃo da aprendizagem matemÃtica com a cultura. Delineamos o trabalho baseados na observaÃÃo participante. Os sujeitos foram 30 alunos do 9. ano do Ensino Fundamental anos finais de uma escola da rede pÃblica municipal de ensino de Caucaia-CearÃ. Como fonte de coleta de dados, adotamos o registro a partir de fotografias e o diÃrio de campo, para anotaÃÃes das respostas produzidas pelos alunos nas AD, bem como comentÃrios de fatos ocorridos durante o processo investigativo durante a SessÃo DidÃtica (SD), fundamentada nos pressupostos metodolÃgicos da SequÃncia Fedathi (SF). Nossos resultados permitiram identificar lacunas conceituais dos estudantes com relaÃÃo Ãs transformaÃÃes geomÃtricas, principalmente com relaÃÃo ao conceito de reflexÃo. Observamos, ainda, dificuldades primÃrias dos estudantes acerca do conceito de lateralidade. A partir das anÃlises, verificamos que as AD propostas por Santos (2012) corroboram a aprendizagem dos conceitos de transformaÃÃo geomÃtrica, especificamente rotaÃÃo, translaÃÃo e reflexÃo, principalmente por evidenciar as habilidades de visualizaÃÃo e representaÃÃo, fundamentais para aprendizagem desses conceitos

Orientador: Vera Aparecida Madruga / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Educação Fisica / Made available in DSpace on 2018-08-14T15:22:08Z (GMT). No. of bitstreams: 1 DiGrazia_RenataCristina_D.pdf: 1299085 bytes, checksum: 4cc0c3ffae29b36284e45a1007c24f5a (MD5) Previous issue date: 2009 / Resumo: O presente estudo teve como objetivo analisar e verificar os efeitos do programa de terapia manual (Método Mulligan associado à massagem clássica) nas queixas de dor e na qualidade de vida de mulheres adultas com disfunção da articulação temporomandibular (DTM). Participaram da pesquisa 29 mulheres, com idades entre 28 e 59 anos (média de idade de 47,41 (dp±6,71) anos), encaminhadas pelo serviço odontológico do Centro de saúde da Comunidade da Unicamp (CECOM). Todas as voluntárias apresentavam DTM e foram avaliadas antes e após programa de terapia manual utilizando-se a escala visual-numérica de dor e o questionário de qualidade de vida SF-36. O programa de terapia manual foi realizado no setor de Fisioterapia do Cecom-Unicamp durante 16 semanas, com 02 sessões/semanais de 30 minutos, em dias alternados. Utilizou-se estatística descritiva para analise dos dados da anamnese e o teste de Wilcoxon (software SPSS, V. 13.0), com nível de significância de 5% (p< 0,05) para os dados coletados na escala de dor e no SF36. Os resultados mostraram na analise das respostas obtidas com a escala visual numérica de dor, onde as voluntárias responderam de 0 a 10, qual era o número que representava sua dor naquele momento, sendo encontrados na condição pré-terapia os valores: 5 (17,2%); 6 (3,4%); 7 (20,7%); 8 (31%); 9 (10,3%) e 10 (17,2%). Após a terapia manual pode-se verificar que o nível de dor caiu, ou seja, para o valor 0 (37,9%), para o valor 1 (24,1%) e para o valor 2 (31%). Os resultados obtidos no questionário de Qualidade de Vida SF-36 mostraram diferenças estatisticamente significantes com p<0,05. Concluindo pode-se inferir que o programa envolvendo tratamento fisioterapêutico através da terapia manual mostrou-se eficiente para o grupo de mulheres com DTM, pois antes do tratamento elas apresentavam um nível de dor elevado e após o programa de terapia manual esse valor mostrou-se reduzido, com melhora do quadro álgico. / Abstract: The actual study had the objective to analyze and verify the effects of a manual therapy program (Mulligan Method associated with classical massage) in the pain complaints and in the quality of life of the adults' woman with the temporomandibular joint diseases (TMJ). Participated of the study, 29 woman, aged between 28- 59 years old (mean 47,41 (dp±6,71)), referred by the dental department in the health center of Unicamp community (CECOM). All the volunteers had TMJ disease and were assessed before and after program of manual therapy using the visual numeric scale of pain and the quality of life questionnaire SF-36. The manual therapy program had been realized in the Physical therapy of Cecom-Unicamp, during 16 weeks, with 2 sections/ week with 30 minutes, in alternate days. We used decrypted statistics to analyze the anamneses dates and the Wilcoxon test (SPSS, V.13.0), the level of significance was 5% (p< 0,05) for dates from visual numeric pain scale and SF-36. The results showed in the answers analysis obtained with the visual numeric scale of pain, where the volunteers must have to answer among 0 and 10, how are the number that represents their pain in that moment, and we had been in the beginning of the therapy the values: 5 (17,2%); 6 (3,4%); 7 (20,7%); 8 (31%); 9 (10,3%) e 10 (17,2%). After the manual therapy we verify that the values decreased so much, to value : 0 (37,9%); 1 (24,1%) ; 2 (31%) e 3 ( 6,9%) 0 (37,9%). In relation from the analyses of the results of the Quality of life questionnaire SF-36, these showed significant statistics differences with p< 0,05. Concluding, we could infer that the program evolved physiotherapy treatment through manual therapy was efficient for the arrange TMJ disease woman, before the therapy they had a high pain level and after these value decrease, with grow better of the pain. / Doutorado / Ciencia do Desporto / Doutor em Educação Física

SF-1 e LRH-1 são fatores de transcrição que exercem um papel fundamental na produção de esteroides nas gônadas e na suprarrenal, além de estarem envolvidos no processo tumorigênico desses órgãos. Por outro lado, POD-1 apresenta menor expressão em carcinomas adrenocorticais, e parece regular Sf-1. Nesse trabalho foi analisado o papel de POD-1 na regulação de SF-1 e de LRH-1 em células de tumores adrenocorticais. A hiperexpressão de POD-1 resultou em redução da expressão SF-1/SF-1. Em contraste, houve um aumento da expressão gênica de LRH-1, devido à diminuição da expressão de SHP, um regulador negativo de LRH-1. Nas células transfectadas com siRNA-POD-1, os níveis de POD-1 foram reduzidos e de SF-1 aumentado, reforçando o mecanismo regulatório entre os fatores. No ChIP assay, POD-1 se ligou a sequência E-box do promotor de SF-1. Por outro lado, não foi caracterizado a ligação de POD-1 no promotor LRH-1, embora POD-1 tenha se ligado ao E-box do promotor SHP. A redução de SF-1 diminuiu a expressão de StAR, mas não modulou a proliferação das células tumorais. Em resumo, POD-1 pode ter um papel mais amplo como regulador da transcrição de fatores que controlam o processo tumorigênico, e é um candidato a gene supressor de tumor nas células adrenocorticais. / SF-1 and LRH-1 have played a critical role in steroid production, adrenal and gonads. Moreover, there are evidences that they have acted in tumorigenesis process in these organs. POD-1 is downregulated in adrenocortical carcinoma (ACC) it seems to regulate Sf-1. In this work, it has been to analyse the role of POD-1 in SF-1 and LRH-1 regulation in adrenocortical tumor cells. The POD-1 overexpression has reduced SF-1/SF-1 expression. However, there was an increase of LRH-1 gene expression due to SHP expression decrease which is negative regulate of LRH-1. The POD-1 and SF-1 gene expression in transfected cells with siRNA-POD-1 has shown POD-1 decrease and SF-1 increase emphasizing a regulatory mechanism between POD-1 and SF-1. By ChIP assay it was shown that POD-1 binded in SF-1 promoter E-box sequence. It was not characterized that POD-1 binded in LRH-1 promoter, although POD-1 can bind in SHP promoter E-box sequence. The reduction of SF-1 expression by POD-1 has decreased the StAR expression, however, it was not enough to change tumor cell proliferation. In summary, POD-1 must have a wider role as regulator of fator transcription which controls tumorigenese process being a possible candidate as tumor supressor gene in adrenocortical cells.