RESUME La Trypanosomiase Humain Africaine (THA) demeure un problème de santé publique pour plusieurs pays en Afrique subsaharienne. Le contrôle de la THA est basé essentiellement sur la stratégie de dépistage actif suivi du traitement des personnes infectées. Le dépistage actif est réalisé par des unités mobiles spécialisées, bien que les services de santé fixes jouent un rôle important en détectant « passivement » des cas. Le dépistage reposait jadis sur la palpation ganglionnaire mais, depuis le développement du test d’agglutination sur carte (CATT), trois possibilités se sont offertes aux programmes de contrôle à savoir: i) continuer avec la palpation ganglionnaire ii) combiner la palpation ganglionnaire avec le CATT iii) recourir au CATT seul. Certains programmes comme celui de la République Démocratique du Congo (RDC) ont opté pour la combinaison en parallèle de la palpation ganglionnaire avec le CATT. Toute personne ayant une hypertrophie ganglionnaire cervicale et/ou un CATT positif est considéré comme suspecte de la THA. Elle sera soumise aux tests parasitologiques de confirmation à cause de la toxicité des médicaments anti-THA. Les tests parasitologiques classiques sont l’examen du suc ganglionnaire (PG), l’examen du sang à l’état frais (SF), la goutte épaisse colorée (GE). La sensibilité de cette séquence a été estimée insuffisante par plusieurs auteurs et serait à la base d’une grande perte de l’efficacité de la stratégie dépistage-traitement. D’autres techniques de concentration ont été développées comme la mini-Anion Exchange Concentration Technique (mAECT), la Centrifugation en Tube Capillaire (CTC) et le Quantitative Buffy Coat (QBC), mais ces techniques de concentration ne sont pas utilisées en routine. En RDC, une interruption des activités de contrôle en 1990 a eu comme conséquence une réémergence importante de la maladie du sommeil. Depuis 1998 les activités de contrôle ont été refinancées de manière structurée. Ce travail vise deux buts à savoir le plaidoyer pour la continuité des activités de contrôle et la rationalisation des stratégies de contrôle. Nous avons évalué l’évolution de la maladie du sommeil en rapport avec le financement, son impact sur les ménages ainsi que la communauté. L’exercice de rationalisation a porté sur les outils de dépistage et de confirmation. Nous avons d’abord évalué la validité des tests, leur faisabilité ainsi que les coûts et ensuite nous avons effectué une analyse décisionnelle formelle pour comparer les algorithmes de dépistage et pour les tests de confirmation. Pendant la période de refinancement structurel de la lutte contre la THA en RDC (1998-2003), le budget alloué aux activités a été doublé lorsqu’on le compare à la période précédente (1993-1997). Le nombre des personnes examinées a aussi doublé mais par contre le nombre des nouveaux cas de THA est passé d’un pic de 26 000 cas en 1998 à 11 000 en 2003. Le coût par personne examinée a été de 1,5 US$ et celui d’un cas détecté et sauvé à 300 US$. Pendant cette période, les activités ont été financées par l’aide extérieure à plus de 95%. Cette subvention pourrait laisser supposer que l’impact de la THA au niveau des ménages et des communautés est réduit mais lorsque nous avons abordé cet aspect, il s’est avéré que le coût de la THA au niveau des ménages équivaut à un mois de leur revenu et que la THA fait perdre 2145 DALYs dans la communauté. L’intervention par la stratégie de dépistage-traitement a permis de sauver 1408 DALYs à un coût de 17 US$ par DALYs sauvé. Ce coût classe l’intervention comme « good value for money ». Le recours au CATT seul s’est avéré comme la stratégie la plus efficiente pour le dépistage actif. Le gain marginal lorsque l’on ajoute la palpation ganglionnaire en parallèle est minime et n’est pas compensé par le coût élevé lié à un nombre important des suspects soumis aux tests parasitologiques. Les techniques de concentration ont une bonne sensibilité et leur faisabilité est acceptable. Leur ajout à l’arbre classique améliore la sensibilité de 29 % pour la CTC et de 42% pour la mAECT. Le coût de la CTC a été de 0,76 € et celui de la mAECT de 2,82 €. Le SF a été estimé très peu sensible. L’algorithme PG- GE-CTC-mAECT a été le plus efficient avec 277 € par vie sauvée et un ratio de coût-efficacité marginal de 125 € par unité de vie supplémentaire sauvée. L’algorithme PG-GE-CATT titration avec traitement des personnes avec une parasitologie négative mais un CATT positif à un seuil de 1/8 devient compétitif lorsque la prévalence de la THA est élevée. Il est donc possible dans le contexte actuel de réduire la prévalence de la THA mais à condition que les activités ne soient pas interrompues. Le recours à un algorithme recourant au CATT dans le dépistage actif et à la séquence PG-GE-CTC-mAECT est le plus efficient et une efficacité de 80%. La faisabilité et l’efficacité peut être différent d’un endroit à l’autre à cause de la focalisation de la THA. Il est donc nécessaire de réévaluer cet algorithme dans un autre foyer de THA en étude pilote avant de décider d’un changement de politique. Le recours à cet algorithme implique un financement supplémentaire et une volonté politique. SUMMARY Human African Trypanosomiasis (HAT) remains a major public health problem affecting several countries in sub-Saharan Africa. HAT control is essentially based on active case finding conducted by specialized mobile teams. In the past the population screening was based on neck gland palpation, but since the development of the Card Agglutination Test for Trypanosomiasis (CATT) three control options are available to the control program: i) neck gland palpation ii) CATT iii) neck gland palpation and CATT done in parallel . Certain programs such as the one in DRC opted for the latter, combining CATT and neck gland palpation. All persons having hypertrophy of the neck gland and/or a positive CATT test are considered to be a HAT suspect. Confirmation tests are necessary because the screening algorithms are not 100 % specific and HAT drugs are very toxic. The classic parasitological confirmation tests are lymph node puncture (LNP), fresh blood examination (FBE) and thick blood film (TBF). The sensitivity of this combination is considered insufficient by several authors and causes important losses of efficacy of the screening-treatment strategy. More sensitive concentration methods were developed such as the mini Anion Exchange Concentration Techniques (mAECT), Capillary Tube Centrifugation (CTC) and the Quantitative Buffy Coat (QBC), but they are not used on a routine basis. Main reasons put forward are low feasibility, high cost and long time of execution. In the Democratic Republic of Congo, HAT control activities were suddenly interrupted in 1990 and this led to an important re-emergence or the epidemic. Since 1998 onwards, control activities were financed again in a structured way. This works aims to be both a plea for the continuation of HAT control as well as a contribution to the rationalization of the control strategies. We analyzed the evolution of sleeping sickness in the light of its financing, and we studied its impact on the household and the community. We aimed at a rationalization of the use of the screening and confirmation tools. We first evaluated the validity of the tests, their feasibility and the cost and we did a formal decision analysis to compare screening and confirmation algorithms. The budget allocated to control activities was doubled during the period when structural aid funding was again granted (1998-2003) compared with the period before (1993-1997). The number of persons examined per year doubled as well but the number of cases found peaked at 26 000 in 1998 and dropped to 11 000 in the period afterwards. The cost per person examined was 1.5 US$ and per case detected and saved was 300 US$. The activities were financed for 95 % by external donors during this period. This subvention could give the impression that the impact of HAT on the household and the household was limited but when we took a closer look at this aspect we found that the cost at household level amounted to one month of income and that HAT caused the loss of 2145 DALYs in the community. The intervention consisting of active case finding and treatment allowed to save 1408 DALY’s at a cost of 17 US$ per DALY, putting the intervention in the class of “good value for money”. The use of CATT alone as screening test emerged as the most efficient strategy for active case finding. The marginal gain when neck gland palpation is added is minor and is not compensated by the high cost of doing the parasitological confirmation test on a high number of suspected cases. The concentration methods have a good sensitivity and acceptable feasibility. Adding them to the classical tree improves its sensitivity with 29 % for CTC and with 42 % for mAECT. The cost of CTC was 0.76 US$ and of mAECT was 2.82 US$. Sensitivity of fresh blood examination was poor. The algorithm LNP-TBF-CTC-mAECT was the most efficient costing 277 Euro per life saved and a marginal cost effectiveness ratio of 125 Euro per supplementary life saved. The algorithm LNP-TBF-CATT titration with treatment of persons with a negative parasitology but a CATT positive at a dilution of 1/8 and more becomes competitive when HAT prevalence is high. We conclude that it is possible in the current RDC context to reduce HAT prevalence on condition that control activities are not interrupted. Using an algorithm that includes CATT in active case finding and the combination LNP-TBF-CTC-mAECT is the most efficient with an efficacy of 80 %. Feasibility and efficacy may differ from one place to another because HAT is very focalized, so it is necessary to test this novel algorithm in another HAT focus on a pilot basis, before deciding on a policy change. Implementation of this algorithm will require additional financial resources and political commitment.

This thesis examines whether and how historians’ reliance on medical treatises has limited the historiography of contagion as it relates to fourteenth through sixteenth century England. It analyses the context, contents, audience, and codicology of six English tractates, four on the plague and two on the sweating sickness. Before the early seventeenth century, most English tractates were translations/adaptations of Continental works, with ‘uniquely English’ content added. Although the plague dominates studies of pre-modern disease, focusing on the plague hinders comparative analyses that can reveal much about contemporary understanding of contagion. The socio-political-professional contexts in which the tractates were written and disseminated affected their contents, circulation and, ultimately, audiences. Although largely ignored by historians, the tractates’ prefatory dedications, together with their codicology, reveals that the texts were likely accessible to non-elite audiences. Rather than being limited to its medical sense, contagion formed part of the larger discourse about the human condition.

Introduction : Cette thèse est constituée de trois articles liés les uns aux autres. Le premier s’attache à clarifier les perspectives théoriques et problèmes conceptuels entourant la notion de capacité/incapacité au travail, sa définition et son évolution au fil du temps. Les deuxième et troisième articles visent à évaluer les effets différentiels selon le genre de déterminants du retour au travail (RAT) et de la durée d’indemnisation ainsi que les coûts associés, dans une population de travailleurs indemnisés à long terme pour troubles musculosquelettiques (TMS). Méthodes : Dans le premier article, une revue systématique des définitions de l’(in)capacité au travail et une analyse comparative basée sur la théorisation ancrée débouchent sur une carte conceptuelle intégrative. Dans le second article, une cohorte de 455 adultes en incapacité à long terme pour TMS au dos/cou/membres supérieurs est suivie cinq ans au travers d’entretiens structurés et de données d’indemnisation. Des modèles de Cox stratifiés par genre ont été utilisés pour évaluer la durée jusqu’au premier RAT. Dans le troisième article, une cohorte populationnelle de 13,073 hommes et 9032 femmes en incapacité prolongée pour TMS au dos/cou/membres supérieurs a été suivie pendant trois ans à l’aide de données administratives. Des modèles de Cox stratifiés par genre ont été utilisés pour étudier la durée d’indemnisation et détecter les effets dépendants du temps. Les coûts ont également été examinés. Résultats : Les définitions analysées dans la première étude ne reflètent pas une vision intégrée et partagée de l’(in)capacité au travail. Cependant, un consensus relatif semble émerger qu’il s’agit d’un concept relationnel, résultant de l’interaction de multiples dimensions aux niveaux individuel, organisationnel et sociétal. La seconde étude montre que malgré des courbes de survie jusqu’au RAT similaires entre hommes et femmes (p =0.920), plusieurs déterminants diffèrent selon le genre. Les femmes plus âgées (HR=0.734, par tranches de 10 ans), d’un statut économique perçu comme pauvre (HR=0.625), travaillant ≥40 heures/semaine en ayant des personnes à charge (HR=0.508) et ne connaissant pas l’existence d’un programme de santé et sécurité sur leur lieu de travail (HR=0.598) retournent moins vite au travail, tandis qu’un revenu brut annuel plus élevé (par $10,000) est un facteur facilitant (HR=1.225). Les hommes de plus de 55 ans (HR=0.458), au statut économique perçu comme pauvre (HR=0.653), travaillant ≥40 heures/semaine avec une charge de travail physique perçue élevée (HR=0.720) et une plus grande précarité d’emploi (HR=0.825) retournent moins rapidement au travail. La troisième étude a révélé que trois ans après la lésion, 12.3% des hommes et 7.3% des femmes étaient encore indemnisés, avec un ratio de coûts homme-femme pour l’ensemble des réclamations de 2.1 :1. L’effet de certain prédicteurs (e.g. revenu, siège de lésion, industrie) varie selon le genre. De plus, l’effet de l’âge chez les hommes et l’effet de l’historique d’indemnisation chez les femmes varient dans le temps. Conclusion : La façon de définir l’(in)capacité au travail a des implications importantes pour la recherche, l’indemnisation et la réadaptation. Les résultats confirment également la pertinence d’investiguer les déterminants du RAT et de l’indemnisation selon le genre. / Introduction: This thesis consists of three interrelated papers. The first one set out to clarify conceptual issues surrounding the notion of work ability/disability, its definition and its evolution over time. The aims of the second and third paper are to assess the differential effect of the determinants of time to return-to-work (RTW) and compensation duration by gender, as well as the related costs, in workers receiving long-term compensation benefits for musculoskeletal injuries (MSIs). Methods: The first study consists of developing an integrative concept map of work (dis)ability through the systematic scoping review of its definitions and a comparative analysis based on the grounded theory approach. In the second study, a cohort of 455 adults on long-term disability due to work-related MSIs of the back/neck/upper limb was followed for five years through structured interviews and administrative databases. Cox regression modeling stratified by gender was used to assess time to a first RTW of at least three days. In the third study, a register-based cohort of 13,073 men and 9032 women with long-term claims related to neck/back/upper-limb MSIs was followed for three years. Main outcomes were compensation duration and costs. Gender stratified extended Cox models were used to study the compensation duration and detect time-varying effects. Results: The definitions analyzed in the first study do not reflect a shared, integrated vision of the exact nature and attributes of work (dis)ability. However, there seems to be a relative consensus that work (dis)ability is a relational concept resulting from the interaction of multiple dimensions at different ecological levels (individual, organizational and societal). The second study showed that despite similar survival curves of time to RTW between men and women on long-term disability (p=0.920), several factors influencing RTW differed by gender. Women’s risk factors included older age (HR=0.734 - in 10 years unit), poor perceived economic status (HR=0.625), working ≥40 hours/week and having dependents (HR=0.508) and awareness of workplace-based occupational health and safety program (HR=0.598); higher gross annual income (in $10,000s) was a facilitator (HR=1.225). In men, being over 55 years old (HR=0.458), poor perceived economic status (HR=0.653), working ≥40 hours/week and high perceived physical workload (HR=0.720) and higher job insecurity (HR=0.825) negatively influenced time to RTW. The third study revealed that three years post-injury, 12.3% of men and 7.3% of women were still receiving compensation benefits, with a male-female cost ratio of 2.1:1 for all compensation claims. Effects of certain predictors (e.g. income, injury site or industry) differed markedly between men and women. Age and claim history had time-varying effects in men and women’s models respectively. Conclusion: The way work (dis)ability is defined has important implications for research, compensation and rehabilitation. Results also confirm the importance of gender-sensitive studies to investigate the determinants of RTW and time on compensation benefits.

Welfare of families with children In my thesis I dealt with welfare of families with children, because it is a topic that is relevant to everyday part of human life, and has been since its conception. The aim was to give an overview of the basic institutes of ensuring welfare of these families with respect to the near future. But the focus was not put only at social welfare as such, but I tried to give an overview of the most important institutes as well as other branches of the law, where I find elements of social welfare either in the form of material welfare, or any other form of protection of people with dependent children, as e.g. their advantage over people who do not care of dependent children. The first chapter deals with the security of families who are expecting a child and with the period after his/her birth. Family Safety in this period is mainly based on the legislation sickness, from which was one of my sources when examining this topic. The second chapter describes the circuit of social welfare benefits to which a family, during the period following the birth of a child, is entitled. This chapter is based on the law of the state social support. The third chapter presents a range of benefits in material need and concept of subsistence. Here I primarily discussed the Act on poverty and the law...

Absenteeism in the workplace is a longstanding challenge practised by employees for various reasons. It persists despite the numerous efforts undertaken to curb it. The City of Tshwane Metropolitan Municipality is concerned with excessive employee absenteeism. Present research evaluates the City of Tshwane’s human resources policy for managing absenteeism. Causes of absenteeism are critically examined, particular attention being paid to the different leave-types that impinge on service delivery within the City of Tshwane. Within a qualitative research framework, personal semi-structured interviews were used to gather data from staff members of the Leave Capturing Office of the City of Tshwane. The targeted office is responsible for leave management, which includes capturing, recording and encashment of leave. In addition to the questionnaire, the leave management policy as well as sick-leave statistics were brought to bear on this study of absenteeism at the City of Tshwane. Study findings highlighted factors such as job dissatisfaction, unpleasant working relations, favouritism, low wages, lack of resources, stress at the workplace alongside boredom with routine unchallenging tasks as significant causes of absenteeism. The study also found sick-leave to be the form of reported absence most misused by employees. In general, employees take two days sick leave, which is the maximum an employee can take without requiring a medical certificate. Recommendations include that management should invest in a total process that can control and mitigate absenteeism related risks that may adversely affect operations at the City of Tshwane. / Public Administration / M. Admin. (Public Administration)

Made available in DSpace on 2016-04-25T19:20:47Z (GMT). No. of bitstreams: 1 Rodrigo Inacio Ribeiro Sa Menezes.pdf: 1734759 bytes, checksum: c1bc6f6f7284e9e3da24350e1be4f158 (MD5) Previous issue date: 2007-08-08 / Focusing on the works of the Rumanian philosopher Emil Cioran (1911-1995), this study proposes an anthropological approach in order to elucidate the author s conception regarding human being. Cioran s writings portrait man as an essentially infirm being, idea from which this study takes off so as to explain what lies behind his anthropological pessimism. For such, it takes gathering, analyzing and interpreting the reflections offered by him on human being his origins, condition, history and destiny and that are spread out throughout his books. Besides, some of his critics will contribute to sustain the hypothesis: more than just a philosopher, Cioran is a religious thinker, whose pessimistic conception regarding human condition is rooted in gnostic soil. As it is intended to be demonstrated, his connections with gnosticism go way beyond a mere intellectual affinity, involving as well a kinship with the bogomils, a gnostic sect which settled in the Balkans during the Middle Ages and which is supposed to have had a significant role in shaping Rumania s cultural identity. Furthermore, it intends to argue that the crisis of insomnia endured by Cioran in his youth period has a cognitive and spiritual character allowing her to be interpreted as a gnosis. At last, this study commits itself with sustaining the following thesis: much more than his readings, it is rather his insomniac experience that turns out to be the decisive event responsible to shape his thought from then on, including his world and man view / Tendo a obra do filósofo romeno Emil Cioran (1911-1995) como objeto, este estudo parte de um recorte antropológico cuja intenção é lançar luzes sobre sua concepção de ser humano. Está presente em sua obra a idéia do homem como um animal enfermo por natureza, sendo este o ponto de partida que nos levará à compreensão do que está por trás do seu pessimismo antropológico. Para tanto, busca reunir, analisar e interpretar as diversas reflexões que o autor desenvolve sobre o ser humano sua origem, condição, história e destino e que se encontram espalhadas através de seus livros. Além de contar com alguns comentadores que contribuem para sustentar a hipótese: mais do que um filósofo, Cioran é um pensador de cunho religioso, cuja concepção pessimista acerca da condição humana encontra raízes no pensamento gnóstico. Conforme pretende demonstrar, sua relação com o gnosticismo vai muito além de uma mera afinidade intelectual, envolvendo também um parentesco com os bogomilos, seita gnóstica que habitou os Bálcãs durante a Idade Média e que teria influenciado profundamente a alma romena. Além disso, tentará mostrar que a crise de insônia sofrida por Cioran na juventude possui um sentido cognitivo e espiritual profundo que permite interpretá-la como uma gnose. Por fim, este estudo se compromete a sustentar a seguinte tese central: mais do que suas leituras, é a experiência de insônia o acontecimento decisivo que determinará todo seu pensamento posterior, sua visão de mundo assim como de ser humano

This thesis examines whether and how historians’ reliance on medical treatises has limited the historiography of contagion as it relates to fourteenth through sixteenth century England. It analyses the context, contents, audience, and codicology of six English tractates, four on the plague and two on the sweating sickness. Before the early seventeenth century, most English tractates were translations/adaptations of Continental works, with ‘uniquely English’ content added. Although the plague dominates studies of pre-modern disease, focusing on the plague hinders comparative analyses that can reveal much about contemporary understanding of contagion. The socio-political-professional contexts in which the tractates were written and disseminated affected their contents, circulation and, ultimately, audiences. Although largely ignored by historians, the tractates’ prefatory dedications, together with their codicology, reveals that the texts were likely accessible to non-elite audiences. Rather than being limited to its medical sense, contagion formed part of the larger discourse about the human condition.

Das Klinoskop ist die Firmenzeitschrift des Klinikums Chemnitz für Mitarbeiter, Patienten, Angehörige und für unsere Partner. Es erscheint in vier bis fünf Ausgaben pro Jahr in einem Umfang von 40 bis 92 Seiten im Vollfarbdruck. Unsere Firmenzeitschrift wurde seit 2006 von einer qualitativen Mitarbeiterinformation kontinuierlich zu einem relevanten Informationsmedium für unsere Partner wie niedergelassene Ärzte weiterentwickelt. Parallel soll das Klinoskop eine Publikation sein, mit der Patienten und Angehörige einen informativen Zugang zu Ihrem Klinkum Chemnitz erhalten. Damit möchten wir auch unseren Anspruch einer offenen Kommunikation unterlegen. / The Klinoskop is the corporate magazine of the Klinikum Chemnitz for our staff, patients and their family members as well as for our cooperating partners. It is published in full colour, with four or five issues per year, and each issue contains between 40 and 92 pages. Since 2006, our corporate magazine has been continuously refined from a high-quality publication for our staff to the relevant information medium for our partners, in particular physicians in private practice. At the same time, the Klinoskop is intended to be a publication that provides patients and their relatives with more detailed information about their Hospital in Chemnitz. This also helps us to emphasize our intentions of fostering open communication.

Das Klinoskop ist die Firmenzeitschrift des Klinikums Chemnitz für Mitarbeiter, Patienten, Angehörige und für unsere Partner. Es erscheint in vier bis fünf Ausgaben pro Jahr in einem Umfang von 40 bis 92 Seiten im Vollfarbdruck. Unsere Firmenzeitschrift wurde seit 2006 von einer qualitativen Mitarbeiterinformation kontinuierlich zu einem relevanten Informationsmedium für unsere Partner wie niedergelassene Ärzte weiterentwickelt. Parallel soll das Klinoskop eine Publikation sein, mit der Patienten und Angehörige einen informativen Zugang zu Ihrem Klinikum Chemnitz erhalten. Damit möchten wir auch unseren Anspruch einer offenen Kommunikation unterlegen. / The Klinoskop is the corporate magazine of the Klinikum Chemnitz for our staff, patients and their family members as well as for our cooperating partners. It is published in full colour, with four or five issues per year, and each issue contains between 40 and 92 pages. Since 2006, our corporate magazine has been continuously refined from a high-quality publication for our staff to the relevant information medium for our partners, in particular physicians in private practice. At the same time, the Klinoskop is intended to be a publication that provides patients and their relatives with more detailed information about their Hospital in Chemnitz. This also helps us to emphasize our intentions of fostering open communication.

Das Klinoskop ist die Firmenzeitschrift des Klinikums Chemnitz für Mitarbeiter, Patienten, Angehörige und für unsere Partner. Es erscheint in vier bis fünf Ausgaben pro Jahr in einem Umfang von 40 bis 92 Seiten im Vollfarbdruck. Unsere Firmenzeitschrift wurde seit 2006 von einer qualitativen Mitarbeiterinformation kontinuierlich zu einem relevanten Informationsmedium für unsere Partner wie niedergelassene Ärzte weiterentwickelt. Parallel soll das Klinoskop eine Publikation sein, mit der Patienten und Angehörige einen informativen Zugang zu Ihrem Klinikum Chemnitz erhalten. Damit möchten wir auch unseren Anspruch einer offenen Kommunikation unterlegen. / The Klinoskop is the corporate magazine of the Klinikum Chemnitz for our staff, patients and their family members as well as for our cooperating partners. It is published in full colour, with four or five issues per year, and each issue contains between 40 and 92 pages. Since 2006, our corporate magazine has been continuously refined from a high-quality publication for our staff to the relevant information medium for our partners, in particular physicians in private practice. At the same time, the Klinoskop is intended to be a publication that provides patients and their relatives with more detailed information about their Hospital in Chemnitz. This also helps us to emphasize our intentions of fostering open communication.