This master's thesis deals with the valuation of BEZNOSKA, s.r.o. Situated in Kladno, the Czech Republic, this company engages in the development and production of instruments and implants for bone surgery. The company was established on the basis of the "surgery" division of then POLDI Kladno at the beginning of the nineties, during the "big privatisation" period. The aim of this thesis is to estimate the market value and investment value of the company as of 31 December 2009 as defined in the International Valuation Standards. The valuation is carried out using two basic methods. The focus of the work is based on the DCF method the result of which is verified by a method based on the market analysis, in particular the similar public company method. The book value method is only complementary. The thesis is divided into six chapters. Sequenced logically, it contains the basic information on the company valued, financial analysis, strategic analysis, analysis and forecast of the value drivers, financial plan and the valuation itself based on the method mentioned above. These topical units are further divided into several subchapters as necessary. Various analyses and statistical methods needed to successfully meet the set objective are applied throughout the text.

Sabe-se que algumas alterações nutricionais maternas durante o período perinatal estão associadas com doenças metabólicas na vida adulta das proles, tais como diabetes melito tipo 2, resistência à insulina, obesidade e hipertensão arterial. O período da gestação em que estas alterações nutricionais influenciam a prole na idade adulta ainda não está elucidado. Modificações epigenéticas têm sido propostas como mecanismos responsáveis por estas desordens metabólicas. Ratas Wistar de doze semanas de idade foram alimentadas com dieta com conteúdo baixo (HO - 0,15% NaCl) ou normal (NR - 1,3% NaCl) de sódio desde o primeiro dia de gestação até o nascimento da prole ou HO durante a primeira (HO10) ou segunda (HO20) metade da gestação. O peso corpóreo e a ingestão de água e ração foram avaliados semanalmente durante a gestação. Teste de tolerância à insulina (ITT) e à glicose (GTT) e HOMA-IR foram realizados nas proles adultas. Expressão gênica por qRT-PCR e metilação do DNA na região promotora dos genes foram mapeadas utilizando tratamento com bissulfito de sódio e avaliadas por pirosequenciamento. O ganho de peso materno foi menor no HO e HO20 na terceira semana de gestação em comparação com NR e HO10. O peso ao nascimento da prole foi menor em machos e fêmeas dos grupos HO e HO20 em relação ao NR e HO10. O HOMA-IR foi maior nos machos com 12 semanas de idade do grupo HO em comparação com NR e com 20 semanas de idade do grupo HO10 em comparação com NR e HO20. Nas fêmeas com 12 semanas de idade o HOMA-IR foi maior no HO10 comparado com HO. Os níveis de insulina no soro foram maiores tanto nos machos com 20 semanas de idade do grupo HO10 comparado com NR quanto nas fêmeas com 12 semanas de idade do grupo HO10 comparado com HO. A área sob a curva do GTT indicou intolerância à glicose nos machos do grupo HO. A porcentagem de metilação das ilhas CpG no promotor dos genes de Igf1, Igf1r, Ins1, Ins2 e Insr no fígado de machos e fêmeas neonatais e no fígado, tecido adiposo branco e músculo em machos com 20 semanas de idade foi influenciada pela baixa ingestão de sal durante a gestação. Nenhuma destas alterações foi identificada nas fêmeas com 20 semanas de idade. Em conclusão, a baixa ingestão de sal na segunda metade da gestação é responsável pelo baixo peso ao nascimento em ambos os sexos. A intolerância à glicose observada na prole adulta ocorreu somente se a dieta hipossódica é dada durante a gestação inteira. Por outro lado, a resistência à insulina em resposta ao consumo de dieta hipossódica durante a gestação está relacionada com o momento em que ocorre este insulto e com o envelhecimento da prole. Também foi observado que alterações na metilação do promotor do gene Igf1 está correlacionado com o baixo peso ao nascimento em resposta a ingestão de dieta hipossódica durante a gestação / It is known that some maternal nutritional alterations during pregnancy are associated with metabolic disorders in adult offspring, such as insulin resistance, type 2 diabetes mellitus, obesity and arterial hypertension. The period of pregnancy in which these nutritional alterations influence adult offspring remains uncertain. Epigenetic changes are proposed to underlie these metabolic disorders. Twelve-week-old female Wistar rats were fed a low-salt (LS - 0.15% NaCl) or normal-salt (NS - 1.3% NaCl) diet since the first day of gestation until delivery or LS during the first (LS10) or second (LS20) half of gestation. Body weight, food and water intake were weekly evaluated during gestation. Blood glucose, insulin (ITT) and glucose (GTT) tolerance tests, HOMA-IR were performed in adult offspring. Gene expression and DNA methylation were mapped using bisulfite treatment evaluated by pyrosequencing in the male and female neonates and adult offspring. Weight gain was lower in LS and LS20 dams than in NS and LS10 dams in the third week of pregnancy. Birth weights were lower in male and female LS20 and LS rats compared with NS and LS10 neonates. HOMA-IR was higher in 12-week-old LS males compared with NS and in 20-week-old male LS10 rats compared with NS and LS20 rats. In 12-week-old LS10 females, HOMA-IR was higher than in LS. Serum insulin levels were higher in 20 week-old LS10 male compared with NS rats and in 12-week-old LS10 female compared to LS rats. The area under the curve of GTT indicated glucose intolerance in 12- and 20-week-old LS male. Methylation of CpG islands of the Insr, Igf1, Igf1r, Ins1 and Ins2 genes in liver in neonates male and female offspring and liver, white adipose tissue and muscle in 20-week-old male offspring were influenced by low-salt intake during pregnancy. None of these alterations was identified in 20-week-old females. In conclusion, low-salt diet consumption in the second half of pregnancy can result in low birth weights in the males and females offspring. Glucose intolerance observed in adult offspring occurred only if low salt intake was given throughout pregnancy. However, insulin resistance in response to low salt intake during pregnancy is related to the time at which this insult occurs and to the age of the offspring. Alterations in the DNA methylation of Igf1 were observed to be correlated with low birth weight in response to low salt feeding during pregnancy

Made available in DSpace on 2016-04-29T13:18:04Z (GMT). No. of bitstreams: 1 Aline Abdelnur.pdf: 2517751 bytes, checksum: f53036a619b1c97b72702d9cd3cb701c (MD5) Previous issue date: 2007-05-15 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The purpose of this study was to compare 3 procedures to establish stimulus control between graphically similar letters. The participants were 12 non literate children, ages 2 to 6.The children were first exposed to an identity matching to sample test with letters. Then, they were randomly assigned to 1 of 3 simple discrimination training procedures: trial and error (in which all trials involved the two final letters), fading (in which intensity of S- was manipulated) and stimulus shaping (in which meaningful pictures were progressively shaped in the final letters). Each child received training in a simple discrimination task with 1 to 3 pairs of similar letters (a/o, a/e, b/d e f/t) and their reversals. Errors in the pretest determined the pairs of letters to be trained. They were then submitted to the the same identity MTS test with letters and to an identity MTS test with syllables, in which the consonants and vowels trained were combined to form 7 syllables, the sample stimuli. The incorrect comparisons were: the sequence vowel plus consonant (equal to the sample) and a syllable with the sample s consonant and a different vowel. A test with the simultaneous presentation of a syllable formed by a consonant + vowel (a true syllable in Portuguese) and a vowel+ consonant (a non existent syllable in Portuguese) was then conducted. Seven syllables were tested. A short simple discrimination training of those syllables with 100% errors during test and a second MTS test with syllables were conducted. Results showed that, although both stimulus control shaping procedures resulted in fewer errors during discrimination training, they were not fully effective in controlling discriminative behavior on the final trials of training and on the identity MTS posttest with letters. Training with fading resulted in more errors in the last trials. The syllable training seemed to be insufficient to establish control by the relative position of letters. Problems with the sequence of training stimuli used for stimulus shaping and the syllable training are discussed / O objetivo desta pesquisa foi comparar 3 procedimentos de estabelecimento de controle de estímulos na aquisição de discriminações entre letras de grafia semelhante. Os participantes foram 12 crianças, com idade entre 2 e 6 anos, que freqüentavam o ensino infantil e não eram alfabetizadas. As crianças foram inicialmente expostas a um pré-teste de matching de identidade de letras com 22 tentativas. Então, elas foram aleatoriamente expostas a 1 dentre 3 procedimentos de treino de discriminação simples entre pares de letras semelhantes: tentativa-e-erro (em que todas as tentativas eram formadas pelas letras finais), fading (em que a intensidade do S- foi manipulada) e shaping de estímulos (em que figuras com significado foram progressivamente modificadas até atingir a forma das letras finais). Cada criança recebeu treino de discriminação simples entre 1 a 3 pares de letras similares (a/o, a/e, b/d e f/t) e suas reversões a depender de seu desempenho no pré-teste. Procedeu-se então ao pós-teste de matching de identidade de letras e a um pré-teste de matching de identidade de sílabas, no qual 7 sílabas formadas pela combinação de consoantes e vogais treinadas eram apresentadas como estímulos modelo. Os estímulos de comparação incorretos eram: a seqüência vogal + consoante (iguais do modelo) e uma sílaba formada pela consoante do modelo e uma vogal diferente. Após este pré-teste, os 7 pares de seqüências consoante + vogal e vogal + consoante compuseram um pré-teste de sílaba x não-sílaba. Os pares com dois erros foram então treinados. Depois deste treino, pós-testes de matching de identidade de sílabas e o pós-teste sílaba x não-sílaba foram conduzidos. Os resultados mostraram que, embora os procedimentos de modelagem do controle de estímulos (fading e shaping) tenham gerado menos erros na aquisição da discriminação, eles não foram totalmente efetivos em gerar transferência de controle de estímulos para a discriminação final requerida entre as letras nas tentativas finais dos treinos e no pós-teste de matching de identidade de letras. Ainda, o procedimento de fading gerou mais erros nas tentativas finais de treino. O treino de sílaba x não-sílaba parece ter sido insuficiente em gerar controle pela posição relativa das letras. Possíveis falhas no planejamento do material de shaping de estímulos e no treino de sílabas são discutidas

Dans cette thèse, nous étudions l’équation parabolique non linéaire ∂ t u = ∆u + a |x|⎺⥾ |u|ᵅ u, t > 0, x ∈ Rᴺ \ {0}, N ≥ 1, ⍺ ∈ R, α > 0, 0 < Ƴ < min(2,N) et avec une donnée initiale u(0) = φ. On établit l’existence et l’unicité locale dans Lq(Rᴺ) et dans Cₒ(Rᴺ). En particulier, la valeur q = N ⍺/(2 − γ) joue un rôle critique. Pour ⍺ > (2 − γ)/N, on montre l’existence de solutions auto-similaires globales avec données initiales φ(x) = ω(x) |x|−(2−γ)/⍺, où ω ∈ L∞(Rᴺ) homogène de degré 0 et ||ω||∞ est suffisamment petite. Nous montrons ainsi que si φ(x)∼ω(x) |x| ⎺(²⎺⥾)/⍺ pour |x| grande, alors la solution est globale et asymptotique dans L∞(Rᴺ) à une solution auto-similaire de l’équation non linéaire. Tandis que si φ(x)∼ω(x) |x| (x)|x|−σ pour des |x| grandes avec (2 − γ)/⍺ < σ < N, alors la solution est globale, mais elle est asymptotique dans L∞(Rᴺ) à eᵗ∆(ω(x) |x|−σ). L’équation avec un potentiel plus général, ∂ t u = ∆u + V(x) |u|ᵅ u, V(x) |x |⥾ ∈ L∞(Rᴺ), est également étudiée. En particulier, pour des données initiales φ(x)∼ω(x) |x| ⎺(²⎺⥾)/⍺, |x| grande, nous montrons que le comportement à grand temps est linéaire si V est à support compact au voisinage de l’origine, alors qu’il est non linéaire si V est à support compact au voisinage de l’infini. Nous étudions également le système non linéaire ∂ t u = ∆u + a |x|⎺⥾ |v|ᴾ⎺¹v, ∂ t v = ∆v + b |x|⎺ ᴾ |u|q⎺¹ u, t > 0, x ∈ Rᴺ \ {0}, N ≥ 1, a,b ∈ R, 0 < y < min(2,N)? 0 < p < min(2,N), p,q > 1. Sous des conditions sur les paramètres p, q, γ et ρ nous montrons l’existence et l’unicité de solutions globales avec données initiales petites par rapport à certaines normes. En particulier, on montre l’existence de solutions auto-similaires avec donnée initiale Φ = (φ₁, φ₂), où φ₁, φ₂ sont des données initiales homogènes. Nous montrons également que certaines solutions globales sont asymptotiquement auto-similaires. Comme deuxième objectif, nous considérons l’équation de la chaleur non linéaire ut = ∆u + |u|ᴾ⎺¹u - |u| q⎺¹u, avec t ≥ 0 et x ∈ Ω, la boule unité de Rᴺ, N ≥ 3, avec des conditions aux limites de Dirichlet. Soit h une solution stationnaire à symétrie radiale avec changement de signe de (E). On montre que la solution de (E) avec donnée initiale λh explose en temps fini si |λ − 1| > 0 est suffisamment petit et si 1 < q < p < Ps = N+2/N−2 et p suffisamment proche de Ps. Ceci prouve que l’ensemble des données initiales pour lesquelles la solution est globale n’est pas étoilé au voisinage de 0. / In this thesis, we study the nonlinear parabolic equation ∂ t u = ∆u + a |x|⎺⥾ |u|ᵅ u, t > 0, x ∈ Rᴺ \ {0}, N ≥ 1, ⍺ ∈ R, α > 0, 0 < Ƴ < min(2,N) and with initial value u(0) = φ. We establish local well-posedness in Lq(Rᴺ) and in Cₒ(Rᴺ). In particular, the value q = N ⍺/(2 − γ) plays a critical role.For ⍺ > (2 − γ)/N, we show the existence of global self-similar solutions with initial values φ(x) = ω(x) |x|−(2−γ)/⍺, where ω ∈ L∞(Rᴺ) is homogeneous of degree 0 and ||ω||∞ is sufficiently small. We then prove that if φ(x)∼ω(x) |x| ⎺(²⎺⥾)/⍺ for |x| large, then the solution is global and is asymptotic in the L∞-norm to a self-similar solution of the nonlinear equation. While if φ(x)∼ω(x) |x| (x)|x|−σ for |x| large with (2 − γ)/α < σ < N, then the solution is global but is asymptotic in the L∞-norm toe t(ω(x) |x|−σ). The equation with more general potential, ∂ t u = ∆u + V(x) |u|ᵅ u, V(x) |x |⥾ ∈ L∞(Rᴺ), is also studied. In particular, for initial data φ(x)∼ω(x) |x| ⎺(²⎺⥾)/⍺, |x| large , we show that the large time behavior is linear if V is compactly supported near the origin, while it is nonlinear if V is compactly supported near infinity. we study also the nonlinear parabolic system ∂ t u = ∆u + a |x|⎺⥾ |v|ᴾ⎺¹v, ∂ t v = ∆v + b |x|⎺ ᴾ |u|q⎺¹ u, t > 0, x ∈ Rᴺ \ {0}, N ≥ 1, a,b ∈ R, 0 < y < min(2,N)? 0 < p < min(2,N), p,q > 1. Under conditions on the parameters p, q, γ and ρ we show the existence and uniqueness of global solutions for initial values small with respect of some norms. In particular, we show the existence of self-similar solutions with initial value Φ = (φ₁, φ₂), where φ₁, φ₂ are homogeneous initial data. We also prove that some global solutions are asymptotic for large time to self-similar solutions. As a second objective we consider the nonlinear heat equation ut = ∆u + |u|ᴾ⎺¹u - |u| q⎺¹u, where t ≥ 0 and x ∈ Ω, the unit ball of Rᴺ, N ≥ 3, with Dirichlet boundary conditions. Let h be a radially symmetric, sign-changing stationary solution of (E). We prove that the solution of (E) with initial value λ h blows up in finite time if |λ − 1| > 0 is sufficiently small and if 1 < q < p < Ps = N+2/N−2 and p sufficiently close to Ps. This proves that the set of initial data for which the solution is global is not star-shaped around 0.

『今昔物語集』（以下簡稱『今昔』）共有三十一巻，是收錄橫跨天竺（印度）、震旦（中國）、本朝（日本）三國的佛教説話與世俗説話的大作品。其成立年代與編者皆不明，約於1130年前後成立。『今昔』是日本文藝中最早有系統地收集笑話的說話集，巻二十八就是『今昔』集中收錄笑話的一巻。 關於日本的笑話，在『今昔』以前的作品中雖然也可以看到許多笑話的故事，但是『今昔』特別將笑話集中收錄於巻二十八，從此點可看出卷二十八應該蘊含了濃厚的編纂意圖。因此，本論文以『今昔』巻二十八為研究対象，針對主題與構成進行考察分析。探討編者透過巻二十八想要傳達什麼？以及卷二十八在『今昔』全書中有何含意。 本論文共有五章，第一章論述研究目的、先行研究與研究方法。第二章分析巻二十八的内容並探討其主題。接著在第三章透過分析類聚語、話末評語的表現來確認其主題。第四章考察巻二十八的登場人物及各話的配列意識，並由登場人物及各話的配列意識來思考卷二十八構成，再次確認此構成中所包含的主題。最後在第五章的結論整理巻二十八的主題與構成，並且檢討「笑」的功能，思考巻二十八如何透過「笑」這一素材來表現其主題。

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This thesis examines how the Supreme Court of Canada, across legal contexts, has tended to conceptualize sexuality. It focuses primarily on areas of public law including sexual assault law, equality for sexual minorities, sexual harassment and obscenity and indecency laws. There were a number of trends revealed upon reviewing the jurisprudence in this area. First, the Court’s decisions across legal contexts reveal a tendency to conceptualize sexuality as innate, as a pre-social naturally occurring phenomenon and as an essential element of who we are as individuals. This is true whether one is speaking of the approach to gay and lesbian rights, the occurrence of sexual harassment, or the sexual abuse of children. However, there is an exception to this trend. The exception relates to the Court’s conceptual approach towards sexual violence against adults. The research revealed, likely as a result of feminist activism both in the legislative and judicial arenas, that there has been a shift in the way that the Court understands sexuality in the context of sexual violence. It is a shift away from understanding it as pre-social and naturally occurring towards understanding it as a product of society, as a function of social context. This change in the Court’s conceptual approach towards sexual violence has engendered a shift in the law’s moral focus as well – a shift away from a moral focus on specific sexual acts and sexual propriety and towards a moral focus on sexual actors and sexual integrity. The thesis weaves together the analytical observations about the jurisprudence just described with a theoretical argument that is both grounded in the case law and which draws upon a number of different theorists. The argument developed suggests that the Court, regardless of the legal issue involved, ought to conceptualize sexuality as socially constructed/ contextually contingent, that it ought to orient itself towards protecting sexual integrity, and that it ought to understand this sexual integrity as a common interest.

Submitted by Gustavo Rabello de Castro (grdcastro@outlook.com) on 2016-01-17T15:36:58Z No. of bitstreams: 1 Dissertacao Final.pdf: 1716177 bytes, checksum: 6516904780e3dae7837ee9b481d63ba7 (MD5) / Approved for entry into archive by BRUNA BARROS (bruna.barros@fgv.br) on 2016-01-21T17:18:28Z (GMT) No. of bitstreams: 1 Dissertacao Final.pdf: 1716177 bytes, checksum: 6516904780e3dae7837ee9b481d63ba7 (MD5) / Approved for entry into archive by Maria Almeida (maria.socorro@fgv.br) on 2016-02-11T17:59:08Z (GMT) No. of bitstreams: 1 Dissertacao Final.pdf: 1716177 bytes, checksum: 6516904780e3dae7837ee9b481d63ba7 (MD5) / Made available in DSpace on 2016-02-11T17:59:18Z (GMT). No. of bitstreams: 1 Dissertacao Final.pdf: 1716177 bytes, checksum: 6516904780e3dae7837ee9b481d63ba7 (MD5) Previous issue date: 2015-04-28 / In this work we focus on tests for the parameter of an endogenous variable in a weakly identi ed instrumental variable regressionmodel. We propose a new unbiasedness restriction for weighted average power (WAP) tests introduced by Moreira and Moreira (2013). This new boundary condition is motivated by the score e ciency under strong identi cation. It allows reducing computational costs of WAP tests by replacing the strongly unbiased condition. This latter restriction imposes, under the null hypothesis, the test to be uncorrelated to a given statistic with dimension given by the number of instruments. The new proposed boundary condition only imposes the test to be uncorrelated to a linear combination of the statistic. WAP tests under both restrictions to perform similarly numerically. We apply the di erent tests discussed to an empirical example. Using data from Yogo (2004), we assess the e ect of weak instruments on the estimation of the elasticity of inter-temporal substitution of a CCAPM model. / Este trabalho trata de testes para o parâmetro de uma variável endógena em modelos de regressão com variáveis instrumentais fracas. Propomos uma nova restrição para o viés dos testes weighted average power (WAP), desenvolvidos em Moreira e Moreira (16, 2013). A motivação para essa nova restrição se baseia na eficiência do teste score sob a hipótese de identificação forte. Essa hipótese permite reduzir o custo computacional dos testes WAP, substituindo a restrição de strongly unbiased. Esta ultima demanda que, sob a hipótese nula, o teste seja ortogonal a uma dada estatística com sua dimensão dada pelo número de instrumentos. A restrição aqui proposta exige somente que o teste seja não correlacionado com uma combinação linear dessa estatística. Nas simulações, ambos os testes apresentam um desempenho numericamente similar. Aplicamos ainda os testes discutidos neste trabalho na estimação da elasticidade de substituição intertemporal de um modelo CCAPM.