Umwelttheoretische Konzepte sind ohne Bilder und Medien nicht denkbar. Der Biologe und Begründer der Umwelttheorie Jakob von Uexküll (1864–1944) verwendete sie auf vielfältige Weise. Er nutzte chronofotografische Aufnahmen von Meerestieren für seine Forschung, beauftragte Interieurmaler, um sein Konzept subjektiver Umwelten zu vermitteln und entwickelte Diagramme und Schemata – darunter die erste Darstellung eines Funktionskreises –, um die Grundlagen seiner Theorie zu verdeutlichen. Die Dissertation gibt einen Überblick über die vielfältigen Verwendungsformen in Uexkülls gesamtem Werk und setzt darauf aufbauend zwei Schwerpunkte: Erstens im frühen 20. Jahrhundert, als Uexküll im Kontext der Arbeit mit chronofotografischen Verfahren seine zentralen Begriffe entwickelte, sich mit den ästhetischen und erkenntnistheoretischen Schriften Adolf Hildebrands und Immanuel Kants auseinandersetzte und begann, Karl Ernst von Baers Wahrnehmungstheorie zu rezipieren. Zweitens im Spätwerk der 1930er Jahre, als die explizit als Bilderbuch unsichtbarer Welten untertitelten Streifzüge durch die Umwelten von Tieren und Menschen erschienen. Die Streifzüge fassen Uexkülls Forschung mit einem Schwerpunkt auf der Sichtbarmachung verschiedener Umwelten sowie einer Veranschaulichung umwelttheoretischer Konzepte zusammen. Die Dissertation untersucht die kulturhistorischen Kontexte der Bilder, ihre Bezüge zu Uexkülls experimenteller Forschung sowie zu zentralen Konzepten seiner Theorie wie Umwelt, subjektive Zeiten und Räume, Bedeutung (Semiotik) und Funktionszusammenhang von Organismus und Umwelt (Gefüge). Anhand der Bildpraxis werden neben den originellen und in u. a. der Ökologie, Kybernetik, Psychoanalyse und Philosophie rezipierten Ansätzen auch die weltanschaulichen, normativen und autoritären Dimensionen in Uexkülls Werk herausgearbeitet. / Umwelt theory concepts are inconceivable without images and media. The biologist and founder of Umwelt theory Jakob von Uexküll (1864–1944) used them in many ways. He used chronophotographic images of marine animals for his research, commissioned interior painters to convey his concept of subjective Umwelten, and developed diagrams and schemes—including the first representation of a functional circle—to clarify the foundations of his theory. This dissertation provides an overview of the diverse uses in Uexküll’s entire oeuvre and, building on this, focuses on two main fields: first, in the early 20th century, when Uexküll developed his central concepts in the context of working with chronophotography, engaged with the aesthetic and epistemological writings of Adolf Hildebrand and Immanuel Kant, and began to receive Karl Ernst von Baer’s theory of perception; and second, in the late 1930s, when the explicitly subtitled “picture book of invisible worlds” Streifzüge durch die Umwelten von Tieren und Menschen (A Foray into the Worlds of Animals and Humans) was published. The book summarizes Uexküll’s research with a focus on making different Umwelten visible as well as demonstrating environmental-theoretical concepts. This dissertation examines the cultural-historical contexts of the images as well as their references to Uexküll’s experimental research and to central concepts of his theory such as the Umwelt, subjective times and spaces, meaning (semiotics), and the functional connection of organism and environment (Gefüge). The practice of images is used to highlight not only the original approaches received in ecology, cybernetics, psychoanalysis, and philosophy, among others, but also the ideological, normative, and authoritarian dimensions in Uexküll’s work.

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This doctoral thesis focuses on the evaluation of the World Bank (WB) performance in delivering development aid to the Least Developed Countries (LDCs). For this purpose, an extensive research was performed to analyze a set of 790 Implementation Completion and Results reports for key economic and financial indicators. Results of this research provide various insights for the appraisal and the results stage of project delivery of the LDCs in different continents. In the final part of the economic and financial analysis the minimum Social Return on Investment (SROI) of the LDCs including all project costs was calculated. This SROI ratio outcome of 1 and 1.06 in the weighted and 1.3 and 1.72 in the unweighted case indicate that projects delivered by the WB have a positive effect on the poor countries. In the second part of this research project the data set of the ICR reports was qualitatively researched for negative ratings according to 3 core assessment categories for the overall project performance: Sustainability, bank performance and borrower performance. As a result the most critical categories respectively risks were outlined. In conclusion, the research analyses and findings support the general demand to provide even more development assistance to poor countries.:Table of Tables and Figures List of Equations List of Abbreviations 1 Introduction 1.1 Introduction to the Topic 1.2 Assessing Poverty Problems and Achieving Economic Growth 1.3 Millennium Development Goals 1.4 Development Aid 2 Research Approach 2.1 Objective 2.2 Structure 2.3 Least Developed Countries 2.4 World Bank 2.5 Data Access and Relevance 2.5.1 Data Basis 2.5.2 Implementation Completion and Results Reports 2.5.3 Project Types 2.6 Term “Performance” 2.7 Study and Research Questions 2.8 Challenges of this Doctoral Thesis 2.9 Contribution of this Thesis 3 Economic and Financial Analysis 3.1 SROI Concept 3.1.1 SROI Definition 3.1.2 SROI Process and Impact Map 3.1.3 Cost-Benefit-Analysis 3.1.4 SROI Calculation 3.2 SROI of World Bank Projects 3.2.1 Purpose of the Cost-Benefit-Analysis 3.2.2 Indicators of the SROI Calculation 3.2.2.1 Net Present Value 3.2.2.2 Capital and Recurring Costs 3.2.2.3 Project Dates and Duration 3.2.2.4 NPV-horizon 3.2.2.5 Discount Rate 3.2.3 Types of NPV-Cost-Ratios 3.2.3.1 Pro-Rata-Capital-Costs Ratio 3.2.3.2 Total-Capital-Costs Ratio 3.2.3.3 Pro-Rata-Capital plus Recurring-Costs Ratio 3.2.3.4 Total-Capital plus Recurring-Costs Ratio 3.2.4 Calculation of the proper SROI Ratio 3.2.5 Portfolio Analysis 3.2.6 Sensitivity Analysis 3.3 Additional Economic and Financial Indicators 3.3.1 Economic Rate of Return 3.3.2 Benefit-Cost-Ratio 3.3.3 Net Benefit 3.3.4 Financial Net Present Value 3.3.5 Financial Rate of Return 4 Results of the Economic and Financial Analysis 4.1 Analysis Approach and Setup 4.2 NPV Outcomes at the Appraisal Stage 4.2.1 Appraisal NPVs of the LDCs 4.2.2 Appraisal NPV Continent Comparison 4.3 NPV Outcomes of the Result Stage 4.3.1 Result NPVs of the LDCs 4.3.2 Result NPV Continent Comparison 4.4 Appraisal vs. Result NPVs 4.4.1 Results of the LDCs 4.4.2 Continent Comparison 4.5 Economic Rate of Return Result Values 4.5.1 Results of the LDCs 4.5.2 Continent Comparison 4.6 Additional Economic and Financial Indicator Result Values 4.6.1 Benefit-Cost-Ratio and Net Benefit 4.6.2 Financial Net Present Value and Financial Rate of Return 4.7 Overall Project Performance 4.7.1 Definition 4.7.2 Overall Project Performance Ratings 4.7.3 Outcome Calculation for Non-Financial Indicator Projects 4.7.4 Verification of Outcomes and Conclusion 4.8 NPV-Cost-Ratios and SROI Calculation 4.8.1 NPV-Cost-Ratios of the ICR Reports 4.8.1.1 Overall Results 4.8.1.2 Continent Comparison 4.8.2 Standardized NPV-Cost-Ratios 4.8.2.1 Overall Results 4.8.2.2 Continent Comparison 4.8.3 Calculating the Minimum SROI Ratio 4.8.3.1 Overall Results of the Capital SROI Ratio 4.8.3.2 Continental Comparison of the Capital SROI Ratio 4.8.3.3 Overall Results of the Minimum SROI Ratio 4.8.3.4 Continental Comparison of the Minimum SROI Ratio 4.8.4 Making Meaning of the Results 4.9 Summary and Conclusion 5 Qualitative Data Analysis 5.1 Content Analysis 5.2 Sustainability 5.2.1 Sustainability Rating Definition 5.2.2 Sustainability Rating Categories 5.3 Bank Performance 5.3.1 Bank Performance Definition 5.3.2 Bank Performance Categories 5.4 Borrower Performance 5.4.1 Borrower Performance Definition 5.4.2 Borrower Performance Categories 6 Results of the Qualitative Data Analysis 6.1 Sustainability 6.1.1 Quantitative Assessment of Sustainability Ratings 6.1.2 Outcome of the Content Analysis 6.1.2.1 Types of Reasons 6.1.2.2 Overall Results 6.1.2.3 Results in Haiti 6.1.2.4 Continent Comparison 6.1.3 Excursus: Positive NPV Projects 6.1.4 Summary and Conclusion 6.2 Bank Performance 6.2.1 Quantitative Assessment of Bank Performance Ratings 6.2.2 Outcome of the Content Analysis 6.2.2.1 Types of Reasons 6.2.2.2 Overall Results 6.2.2.3 Results in Haiti 6.2.2.4 Continent Comparison 6.2.3 Summary and Conclusion 6.3 Borrower Performance 6.3.1 Quantitative Assessment of Borrower Performance Ratings 6.3.2 Outcome of the Content Analysis 6.3.2.1 Types of Reasons 6.3.2.2 Overall Results 6.3.2.3 Results in Haiti 6.3.2.4 Continent Comparison 6.3.3 Summary and Conclusion 7 Overall Summary and Conclusion 8 Critical Acclaim and Recommendations 9 Outlook and Future Research List of Appendices Appendix References

Many imprinted genes are necessary for normal human development. Approximately 70 imprinted genes have been identified in humans. I developed a novel approach to identify candidate imprinted genes in humans using the premise that imprinted genes are often associated with nearby parent-of-origin-specific DNA differentially methylated regions (DMRs). I identified parent-of-origin-specific DMRs using sodium bisulfite-based DNA (CpG) methylation profiling of uniparental tissues, mature cystic ovarian teratoma (MCT) and androgenetic complete hydatidiform mole (AnCHM), and biparental tissues, blood and placenta. In support of this approach, the CpG methylation profiling led to the identification of parent-of-origin-specific differentially methylated CpG sites (DMCpGs) in known parent-of-origin-specific DMRs. I found new DMRs for known imprinted genes NAP1L5 and ZNF597. Most importantly, I discovered many new DMCpGs, which were associated with nearby genes, i.e., candidate imprinted genes. Allelic expression analyses of one candidate imprinted gene, AXL, suggested polymorphic imprinting of AXL in human blood.

Many imprinted genes are necessary for normal human development. Approximately 70 imprinted genes have been identified in humans. I developed a novel approach to identify candidate imprinted genes in humans using the premise that imprinted genes are often associated with nearby parent-of-origin-specific DNA differentially methylated regions (DMRs). I identified parent-of-origin-specific DMRs using sodium bisulfite-based DNA (CpG) methylation profiling of uniparental tissues, mature cystic ovarian teratoma (MCT) and androgenetic complete hydatidiform mole (AnCHM), and biparental tissues, blood and placenta. In support of this approach, the CpG methylation profiling led to the identification of parent-of-origin-specific differentially methylated CpG sites (DMCpGs) in known parent-of-origin-specific DMRs. I found new DMRs for known imprinted genes NAP1L5 and ZNF597. Most importantly, I discovered many new DMCpGs, which were associated with nearby genes, i.e., candidate imprinted genes. Allelic expression analyses of one candidate imprinted gene, AXL, suggested polymorphic imprinting of AXL in human blood.