Orientador: Milton Jose de Almeida / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Educação / Made available in DSpace on 2019-01-04T15:17:55Z (GMT). No. of bitstreams: 1 Rodrigues_UbirajaraAlencar_M.pdf: 90714835 bytes, checksum: 3a881fbca943a7ba06c7c2e7fcb234a1 (MD5) Previous issue date: 2008 / Resumo: Esse texto é uma introdução ao livro "Hypnerotomachia Poliphili", de autoria do dominicano Francesco Colonna, publicado em 1499 pelo editor Aldo Manuzio. É também uma introdução às técnicas da impressão xilográfica utilizadas nas ilustrações desse livro, e à história da tipografia veneziana em fins do século XV. A concepção gráfica e visual desse livro famoso são modelares e persistem até hoje / Abstract: This is an introduction to the book "Hypnerotomachia Poliphili", from dominican Francesco Colonna, and published by Aldo Manuzio, in 1499. It's also na introduction to the techniques of xylography printing used to illustrate this book, and the history of venetian typography at the end of the 15th century. The graphic tradition and visual approach of this remarkable book persist as model up to now / Mestrado / Educação, Conhecimento, Linguagem e Arte / Mestre em Educação

Na concepção do mundo cristão, as mulheres foram criadas a partir de um fragmento masculino para lhe serem sujeitas, nunca iguais. Essa ordenação vai determinar a concepção sobre o feminino e a importância da imposição de submissão às mulheres. Sua inferioridade era impedimento para o ofício religioso e as leis do reino reconheciam a fraqueza própria do seu sexo que lhes vedava o acesso a ofícios públicos. Entretanto, é preciso considerar que entre o que se preconizava e o que de fato se praticava havia um cuidadoso jogo de possibilidades. A condição feminina definida eminentemente por sua ligação e sua relação com um homem que as caracterizava como mulheres solteiras, casadas ou viúvas não representa a multitude de papéis que poderiam desempenhar ao longo de sua vida. Seu estado não era necessariamente um obstáculo para o desempenho de outros papéis. O entrecruzamento dos dados obtidos com a análise da lei e da prática nos mostra que não precisa haver aí uma dicotomia. No seu viver em sociedade, as mulheres conjugavam diversos fatores e assumiam facetas muito mais ricas do que consideravam os escritos dos teólogos e moralistas. / In the design of the Christian world women were created from a mans fragment to be his subject and never an equal. This disposition would determine the conception of the feminine and the importance of the control to which women should be referred. Their inferiority was an obstacle for religious service and the laws of the kingdom recognized the archetypal weakness of their sex forbidding them access to public offices. However it is necessary to consider that between what was preached and what was practiced there were many possibilities. Womens social condition defined by their connection and relationship with a man who characterized them as a single, married or widowed women did not represent the multitude of roles they could play throughout his life. Their condition was not necessarily an obstacle to the performance of other roles. The data obtained with the analysis of the law and practice shows that it didnt had to be a dichotomy. In their social lives women combined several factors and assumed much richer facets than that considered in the writings of theologians and moralists.

Made available in DSpace on 2014-06-11T19:26:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-09-13Bitstream added on 2014-06-13T20:47:09Z : No. of bitstreams: 1 mercuri_do_me_fran_parcial.pdf: 228474 bytes, checksum: 9d916aa7d6a19a853fbc3498d80437fb (MD5) Bitstreams deleted on 2014-08-22T14:57:12Z: mercuri_do_me_fran_parcial.pdf,Bitstream added on 2014-08-22T15:02:12Z : No. of bitstreams: 1 000695152.pdf: 1064881 bytes, checksum: 70f6e1f550db0258c453cd74642424f8 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / La présente recherche a comme proposition rechercher les récits des chroniqueurs ibériques, produits pendant les XIVe et XVe siècles , avec la finalité d'examiner comment le divin a été utilisé dans la construction de l'image des rois castillans et portugais. Les chroniques sélectionnées ont été les Castillanes des rois D. Pedro, D. Henrique II, D. João I et D. Henrique III, écrites par le chancelier Pero López de Ayala, et les chroniques des rois D. Pedro, D. Fernando et D. João I (1ère et 2e parties), écrites par le premier chroniqueur officiel royal portugais, Fernão Lopes. Comme les deux chroniqueurs ont été officiels royaux à service des nouvelles, et au début illégitimes, dynasties de Trastamare et d'Avis, respectivement en Castille et Portugal, chacun à sa manière a cherché écrire pour justifier les nouvelles maisons royales, inaugurées par un fratricide, dans le premier cas, et par un bâtard, dans le second. Au cours de la recherche sur les formes qui ont prises la sacralisation du pouvoir des rois castillans et portugais, l'objectif du travail a été, premièrement, examiner et comparer la production chronistique castillanne et portugaise à la fin du XIVe siècle et au début du XVe, ainsi que les rôles joués par Pero López de Ayala et Fernão Lopes dans les royaumes de Castille et Portugal. Dans une deuxième étape, l'objectif de cette recherche a été s’interroger sur les approches et les éloignements en appel aux références sacrées – longtemps partagées entre les royaumes chrétiens - pour composer et affirmer le pouvoir royal dans ces royaumes / A presente pesquisa tem como proposta indagar os relatos cronísticos ibéricos, produzidos nos séculos XIV e XV, com a finalidade de examinar como o divino foi usado na construção da imagem dos reis castelhanos e portugueses. As crônicas selecionadas foram as castelhanas dos reis D. Pedro, D. Henrique II, D. João I e D. Henrique III, escritas pelo chanceler Pero López de Ayala, e as crônicas dos reis D. Pedro, D. Fernando e D. João I (1ª e 2ª partes), escritas pelo primeiro cronista oficial régio português, Fernão Lopes. Como ambos os cronistas foram oficiais régios a serviço das recém-constituídas, e a princípio ilegítimas, dinastias de Trastâmara e de Avis, respectivamente em Castela e Portugal, cada um a seu modo buscou escrever para justificar as novas casas reais, inauguradas por um fratricida, no primeiro caso, e por um bastardo, no segundo. No percurso de indagação sobre as formas que assumiu a sacralização do poder dos reis castelhanos e portugueses, o objetivo do trabalho foi, primeiramente, examinar e comparar a produção cronística castelhana e portuguesa em finais do século XIV e início do XV, bem como os lugares ocupados por Pero López de Ayala e Fernão Lopes nos reinos de Castela e Portugal. Em um segundo momento, a meta desta pesquisa foi interrogar sobre as aproximações e os distanciamentos no apelo às referências sagradas – partilhadas de longa data nos reinos cristãos – para compor e afirmar o poder real nesses reinos

Orientador: Paulo Celso Miceli / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Filosofia e Ciencias Humanas / Made available in DSpace on 2018-08-03T04:13:33Z (GMT). No. of bitstreams: 1 Sales_MarianaOsueIde_M.pdf: 13751283 bytes, checksum: adcf7fc612b06c0e678c3a78d4ae1a85 (MD5) Previous issue date: 2003 / Resumo: Nesta pesquisa buscamos explorar algumas imagens do mar em textos galego-portugueses entre os séculos XIII e XV, especificamente em algumas cantigas d'amigo - as barcarolas ou marinhas -e em textos de caráter hagiográfico e moralizante. Pretendemos confrontar essas imagens socialmente compartilhadas com parte considerável da bistoriografia sobre a Era dos Descobrimentos portugueses que afmna que Portugal, desde a Idade Média, manifestava uma "vocação" marítima. Nossa intenção, com isso, foi questionar e desnaturalizar a idéia do destino marítimo / Abstract: We tried to study some images of the sea in galician-portugueses textes between the XIIIth and XVth centuries; some cantigas d'amigo, the barcarolas or marinhas and a few textes of moral sense and hagiographal caracter. Our aim was to confront those images socially shared with considerable part of the bistoriography about the portuguese Age of Discoveries that assures that Portugal, since Middle Ages, has manifest a maritime "vocation". Our intention was to question the idea of the maritime destiny / Mestrado / Mestre em História

Aujourd’hui disparu, le château de Choisy-le-Roi reste bien souvent dans les esprits un symbole des fantaisies coûteuses de Louis XV et de Mme de Pompadour, idée répandues par la littérature et les chroniques des XVIIIe et XIXe siècles. Choisy occupe cependant une place majeure dans l’histoire de l’architecture des programmes mis en place pour les besoins de la vie de cour de la deuxième moitié du XVIIIe siècle. Proche de la forêt de Sénart, le château devient d’abord une résidence conviviale où se retrouve, après les parties de chasse, une « cour particulière », composée des familiers du roi et de la favorite. Louis XV convie par la suite à Choisy ses enfants, auxquels il consacre de courts séjours dans un cadre moins protocolaire. La suite nombreuse attachée à leur service transforme cet espace auparavant « privé », et le rend plus accessible aux courtisans. Cette augmentation de la fréquentation entraîne de nombreux travaux dirigés par l’architecte Ange-Jacques Gabriel. En conséquence de cette perte d’ « intimité », d’autres lieux particuliers sont alors aménagés ; ainsi, le Petit-Château, premier pavillon d’habitation de Louis XV, est construit. C’est là où prend place la table « volante ». À travers l’étude du domaine royal, on perçoit également le fonctionnement quotidien du château, où vivent de nombreux employés attachés à l’administration des Bâtiments du roi. Le travail sur le terrain est coordonné par un contrôleur des Bâtiments, dont les lettres échangées avec le Directeur de l’administration délivrent de précieuses informations sur la gestion et le personnel. Ainsi, le château de Choisy apparaît comme une pièce majeure pour la compréhension de la cour et de la sociabilité de Louis XV. / Today disappeared, the castel of Choisy-le-Roi remains as a symbol of the Louis XV and Mme de Pompadour’s expensive whims, idea spread by the 18th and 19th centuries literature. However, Choisy has an important part in the history of the programs architecture set up for the needs for the life of court of the second half of the 18th century. Close to the forest of Sénart, the castel becomes at first a friendly residence where finds itself, after the hunting trips, a " particular court ", made up of the king ’s close friends. Louis XV invites later to Choisy his children, to whom he dedicates short stays in a informal settings. The numerous entourage attached to their service transforms this space previously "private", and makes it more accessible to the courtiers. This increase of the company produces many construction works by the architect Ange-Jacques Gabriel. As a result of this loss of "intimacy", other intimate places are then fitted out; so, the Petit-Château, the first detached house of Louis XV, is built. It is where takes place the table « volante ». Through the study of the royal domain, we also notice the daily functioning of the castel, where live numerous employees attached to the administration des Bâtiments du roi. The field works is coordinated by a controller des Bâtiments, from whom letters exchanged with the Director of the administration give valued informations on management and staff. So, the castel of Choisy appears as a major part for the understanding of the court and the sociability of Louis XV.

Fra Bernat Hug de Rocabertí (c.1420-1485) was a prominent member of the Order of the Hospital in the Crown of Aragon in which to attain the dignity of Castilian of Amposta, the most important dignity in the Crown. This work is a historical biography of him, since he entered into the Order by the hand of his brotherin- law, fra Joan de Vilagut, until he became a confidant of King Joan II and his side took part in Catalan Civil War in the fifteenth century. In parallel, Rocabertí also devoted himself to poetry and wrote at least two pieces, the Estrampa, so far unpublished, here this work is published critically, and La glòria d’amor, a long narrative poem, which is a study of possible chronology. Moreover, also studied other people linked to Bernat Hug, like his brothers, authors of some interesting battle letters, also published for the first time, or their brothers-inlaw, among them Joan de Vilagut, also a poet, and Guillem Tinter, who had a poetic Exchange with Vilagut. The whole work is accompanied by transcription of an interesting collection of documents. / Fra Bernat Hug de Rocabertí (c.1420-1485) fou un membre destacat de l'Orde de l'Hospital a la Corona d'Aragó en la qual va arribar a assolir la dignitat de Castellà d'Amposta, la més important d'aquest orde a la Corona. En el treball es fa una biografia històrica del personatge, des que va entrar a l'orde de la mà del seu cunyat, fra Joan de Vilagut, fins que va esdevenir un home de confiança del rei Joan II i al seu costat va participar a la Guerra Civil Catalana del segle XV. En paral·lel, Rocabertí també es va dedicar a la poesia i va compondre almenys dues peces, l'Estrampa, fins avui inèdita i que s'edita críticament, i La glòria d'amor, un llarg poema narratiu, del qual es fa un estudi de la possible cronologia. Per altra banda, també s'estudia altres personatges lligats a Bernat Hug, com el seus germans, autors d'unes interessants lletres de batalla que també s'editen, o els seus cunyats, entre els que destaca Joan de Vilagut, poeta també, alhora que s'aporten dades sobre Guillem Tinter, amb qui Vilagut va tenir un intercanvi poètic. El conjunt del treball s'acompanya amb la transcripció d'una interessant col·lecció de documents d'arxiu.

Orientador: Mário Tyago Murakami / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia / Made available in DSpace on 2018-08-20T10:58:02Z (GMT). No. of bitstreams: 1 Polo_CarlaCristina_M.pdf: 4286137 bytes, checksum: cf12a2b67d90255468d1906d719759a3 (MD5) Previous issue date: 2012 / Resumo: As miosinas pertencem a uma família de proteínas motoras que através da hidrólise de ATP são capazes de se movimentarem pelas fibras de actina. Sua estrutura é dividida em três domínios principais: motor, responsável pela hidrólise do ATP; regulador, envolvido na ligação de cadeias leves de calmodulina e a cauda, que tem papel essencial na mediação de interações com cargas celulares, como organelas, ácidos nucleicos e outras proteínas. O organismo modelo para insetos, Drosophila melanogaster, possui 11 miosinas pertencentes a 8 classes sendo que informações funcionais e bioquímicas são escassas, e estruturais, inexistentes. Apesar dos grandes avanços obtidos nos estudos de miosinas humanas, as miosinas de inseto ainda são pouco caracterizadas não havendo estudos comparativos, como por exemplo, para a determinação de conservação de parceiros moleculares entre os diferentes filos da classificação de Lineu. Neste contexto, foram selecionados os seguintes domínios de inseto para caracterização molecular: quinase da miosina III, cauda globular da miosina V e FERM da miosina XV. A partir do cDNA da pupa e adulto do inseto foram amplificados os fragmentos de genes de interesse e clonados em vetor de clonagem, pGEM T-easy, e posteriormente de expressão, pET28a e pET28aSUMO. Após testes em diversas condições no sistema bacteriano, as construções cauda globular da miosina V (GLOB_2 e GT-f) e domínio FERM-f da miosina XV foram obtidos na fração solúvel e com rendimento suficiente para estudos estruturais. O protocolo de expressão em larga escala assim como de purificação foram estabelecidos para cada uma dessas construções. Estudos biofísicos por aSEC, DLS, CD e SAXS foram realizados para a proteína GT-f da miosina V, mostrando a proteína monomérica com alto conteúdo de hélices-alfa corroborando as análises in silico e com as caudas globulares de miosinas ortólogas já descritas. Além disso, sua termoestabilidade foi avaliada com Tm de 46 ºC e que sua estabilidade é alterada pela adição de alguns ligantes, mas não pela força iônica como verificado para a cauda globular da miosina Va humana. A estrutura a baixa resolução da GT-f foi determinada pelos experimentos de SAXS, mostrou uma proteína monomérica com forma alongada (Dmax =100 Å). Para a construção FERM-f, apesar do sucesso alcançado no protocolo de expressão e purificação, a amostra permaneceu polidispersa e com uma estrutura random coil, inviabilizado futuros experimentos. Acredita-se que a ausência do domínio MyTH4, gerou a perda de estabilidade do domínio FERM-f e será necessária a clonagem dos dois domínios fusionados para garantir a estabilidade estrutural e funcional / Abstract: Myosins belong to a motor protein superfamily that uses the ATP hydrolysis to move along actin filaments. Its structural architecture comprises three main domains: motor, responsible for ATP hydrolysis; regulator, which binds calmodulin light chains; and tail, responsible for cellular cargoes binding. Drosophila melanogaster, an insect model, has 11 myosins belonging to 8 different myosin classes; however functional and biochemical data are scanty, and, structural, absent. Although the great advances on investigating human and yeast myosins with the elucidation of molecular partners and molecular mechanisms involved in signaling, there are no comparative studies among different phyla. Therefore, in order to gain insights into insect myosins, in silico analysis were performed and some domains like kinase (myosin III), globular tail (myosin V), and FERM (myosin XV) were selected for biophysical and structural studies. From pupa and adult cDNAs, the target genes were amplified and cloned into pGEM- T-easy, pET28a and pET28aSUMO vectors. After expressions tests, the myosin V globular tail constructs, GLOB_2 and GT-f, and myosin XV FERM-f were obtained in soluble fraction and in sufficient amounts for structural studies. aSEC, DLS, CD e SAXS biophysical studies were performed to myosin V GT-f, showing that the protein is monomeric with predominance of alpha-helix in accordance with the in silico atomic model. The stability of GT-f was assessed with a Tm of 46 ºC and some molecules are able to increase the stability, while the ionic strength has no difference like was observed for the human globular tail of myosin Va. The low resolution structure determined by SAXS experiments confirmed the monomeric state and its elongated molecular shape (Dmax = 100 Å). The FERM-f construct, although the purification and expression protocol were standardized, the sample remained polydisperse with a random coil structure, disabling other biophysical experiments. It is supposed that the absence of the MyTH4 domain in the FERM-f domain results in loss of stability, and cloning and expression of fused domains will be necessary to guarantee structural and functional stability / Mestrado / Bioquimica / Mestre em Biologia Funcional e Molecular

L'intérêt scientifique pour l'image de Louis XV et Louis XVI a été jusqu'ici bien moindre que celui manifesté pour celle de leur glorieux ancêtre, Louis XIV. Cette situation a pu être encouragée par une historiographie inclinant à l'hypothèse de la désacralisation de la monarchie au XVIIIe siècle. Il en aurait résulté une dégradation de l'image royale, la monarchie étant incapable de faire face au rôle de plus en plus déterminant joué par la sphère publique. Or, ce travail cherche à montrer que c'est précisément en raison de la prise en compte de l'opinion que cette image royale se redéfinit à cette période, une redéfinition qui apparaissait d'autant plus nécessaire après la défaite dans la Guerre de Sept Ans. C'est bientôt la représentation d'un roi simple et bienfaisant, inspirée par Stanislas Leszczynski, qui s'impose et qui contribue à la popularité de Louis XVI pendant son règne. Ainsi, la représentation royale évolue en se donnant de nouveaux modèles. Elle tire en outre parti d'une multiplicité de supports de diffusion dont la démocratisation permet de toucher un large public. Enfin, cette image ne se conçoit plus sans un nouvel acteur : la presse qui sert à la fois à promouvoir l'iconographie royale, à préciser son sens et à lui donner consistance. / Up to now, scholarly studies have shown less interest in the image of Louis XV and Louis XVI than in the one of their glorious ancestor, Louis XIV. This situation may have been encouraged by a historiography fostering the hypothesis of the desacralization of the monarchy in the 18th century. It would have led to a degradation of the royal image, with the monarchy being unable to face up to the growing influence of the public sphere. Yet, this dissertation tries to show that it precisely was because public opinion was taken into account that the royal image was redifined at the period. It appeared all the more necessary after the defeat in the Seven Years War. Soon afterwards, the representation of a simple and benevolent king, inspired by Stanislas Leszczynski, began to prevail and contributed much to the popularity of Louis XVI during his reign. Thus, the royal representation evolved and refered to new models. It also made good use of the democratization of multiple diffusion mediums enabling it to reach a larger public. Finally, the royal image could not be contemplated without paying attention to a major new actor: the press. It was used to promote the new royal iconography but it also precised its meaning and gave it some intellectual substance.

Abstract Collagen XV is a proteoglycan localized in the outermost layer of the basement membrane (BM) and in the fibrillar matrix. Although it is widely distributed in many tissues, its amount is generally low. It is characterized by a highly interrupted collagenous domain flanked by large globular domains and attached glycosaminoglycan chains, thus also being identified as a chondroitin sulphate proteoglycan. The C-terminal end of collagen XV, termed restin, has proved to have antiangiogenic effects. In view of its location in the outermost layer of the lamina densa and in association with interstitial collagen fibrils near BMs, it has been suggested that collagen XV may form a bridge between the fibrillar collagen matrix and the BMs. In vivo studies of mice lacking collagen XV have demonstrated that collagen XV is needed as a structural component to stabilize the skeletal muscle cells and capillaries. The role of collagen XV in the extracellular matrix (ECM) was studied using a mouse model lacking the gene of interest (Col15a1-/-). The matrix of peripheral nerves, skeletal muscle, heart and the uterus during pregnancy was analysed at several time points, and peripheral nerve development was evaluated in a mouse model lacking collagen XV and the laminin α4 chain simultaneously as well as in Col15a1-/- mice. The function of collagen XV in the heart was analysed in young, adult and old mice separately. The results indicate that collagen XV is needed for organizing collagen fibrils into proper bundles in the cardiac ECM. In the developing nerve it regulates collagen fibril size and the organization of the fibrils within the collagen bundle. In mature nerves and skeletal muscles it structures the BM–fibrillar matrix interphase, and in the uterus of pregnant mice it participates in fibrillar collagen remodelling, affecting the lateral fusion of collagens into thick fibrils. Even delicate changes in the matrix can lead to an alteration in the functioning of certain organs. Abnormal C-fibrils, polyaxonal myelination and decreased sensory conduction velocity were observed in the Col15a1-/- peripheral nerves, and a simultaneous lack of collagen XV and the laminin α4 chain resulted in more severe and permanent impairment of the segregation and myelination of the nerve axons. A complex cardiac phenotype was observed in the Col15a1-/- mice, predisposing them to cardiomyopathy. / Tiivistelmä Kollageeni XV on proteoglykaani, jonka lokalisaatio on tyvikalvon uloimmassa kerroksessa ja soluväliaineen säikeissä. Vaikka sitä tuotetaan laajalti useissa eri kudoksissa, sitä on määrällisesti vähän kudoksissa. Kollageenin XV ominaisuuksiin kuuluvat useat katkokset kollageenisilla alueilla, globulaariset alueet proteiinin päissä, sekä siihen kiinnittyneet glykosaminoglykaaniketjut, jotka on tunnistettu kondroiittisulfaatiksi. Kollageenin XV C-terminaalisella osalla, jota kutsutaan restiniksi, on osoitettu olevan antiangiogeneettisiä vaikutuksia. Ottaen huomioon kollageeni XV lokalisaation tyvikalvon uloimmassa kerroksessa, ja sen liittymisen säikeisiin kollageeneihin lähellä tyvikalvoa, on ehdotettu että sen tehtävänä olisi toimia yhteys-siltana säikeisten kollageenien ja tyvikalvon välillä. In vivo tutkimuksissa kollageeni XV poistogeenisillä hiirillä on osoitettu, että kollageenia XV tarvitaan rakenteellisena osana stabiloimaan luurankolihasta sekä hiussuonia. Kollageenin XV merkitystä sidekudoksessa tutkittiin käyttäen hiirimallia, jolta puuttuu kyseinen geeni (Col15a1-/-). Ääreishermojen, luurankolihaksen, sydämen ja kohdun soluväliainetta analysoitiin eri-ikäisillä hiirillä. Lisäksi ääreishermojen kehitystä tutkittiin hiirimallilla, jolta puuttuu sekä kollageeni XV että laminiini α4-ketju samanaikaisesti, sekä Col15a1-/- hiirillä. Kollageenin XV tehtävää sydämessä analysoitiin nuorilla, aikuisilla ja ikääntyneillä Col15a1-/- hiirillä. Tulokset viittaavat kollageeni XV merkittävään rooliin soluväliaineen järjestäytymisessä, erityisesti kollageenisäikeiden järjestäytymisessä kimpuiksi sydämen soluvälitilassa. Kehittyvässä hermossa sen tehtävä on säädellä säikeisten kollageenien läpimittaa sekä säikeiden järjestäytymistä säiekimpun sisällä. Täysin kehittyneessä hermossa ja luurankolihaksessa se strukturoi tyvikalvon ja säikeisen soluväliaineen välitilaa, kun taas raskaana olevien hiirien kohdussa se osallistuu säikeisten kollageenien muokkaukseen, vaikuttamalla kollageenien paksuuntumiseen lateraalisen fuusion kautta. Jopa hienoiset muutokset soluväliaineen rakenteessa voivat johtaa muutoksiin elinten toiminnassa. Epämuodostuneita C-säikeitä, polyaksonaalista myelinisaatiota ja hidastunutta sensorista johtonopeutta todettiin Col15a1-/- perifeerisissä hermoissa. Samanaikainen kollageenin XV ja laminiini α4-ketjun puutos johtivat vaikeampaan ja pysyvämpään haittaan hermon aksonien segregaatiossa ja myelinisaatiossa. Col15a1-/- hiirillä todettiin monimuotoinen sydämen ilmiasu, joka altistaa hiiret kardiomyopatialle.

Le sujet principal de la thèse consiste à reconstituer les négociations diplomatiques intenses et complexes entre France et d’autres cours du Sud (l’Autriche, l’Espagne, la Saxe) entre deux dates symboliques, la mort du roi saxon de Pologne Auguste III (le 5 octobre 1763) et la reconnaissance tardive de la France de son successeur sur le trône de Pologne (juin 1766), Stanislas-Auguste, de la famille polonaise des Poniatowski, élu le 7 septembre 1764, le candidat de la Russie. / The main goal of the dissertation was to present a complex diplomatic negotiations between France and other courts of South (Austria, Spain and Saxony) the day after death of Augustus III (5 X 1763), and the late acknowledgement (juin 1766) of his successor Stanislaus-Augustus, from the polish noble family of Poniatowski (elected the 7th of september 1764 as a russian candidate).