Made available in DSpace on 2015-04-14T14:27:09Z (GMT). No. of bitstreams: 1 458453.pdf: 1183986 bytes, checksum: 7e3d255424b837d3aee1dcc67c93f1e0 (MD5) Previous issue date: 2014-03-19 / The aim of this work is to examine in exploratory way the economic diversity of the microregions of southern Brazil in two periods: 2002 and 2010. The study uses information from formal employment, obtained in the Annual Report of Social Information (RAIS), for a set of 25 sub-sectors of the Brazilian Institute of Geography and Statistics (IBGE), distributed in 94 South Brazilian microregions. The research uses both the entropy and Herfindahl indexes to calculate diversity for each of the South Brazilian microregions. It evaluates together employment levels with shift-share technique the relevance of national, sectoral and competitive effects on regional economic growth, and utilizes Pavitt taxonomy for evaluates the most technological localities. The results indicate that the most diversified regions are those with large populations. Overall, the micro-regions analyzed showed positive results in Industry Mix, highlighting the microregions of Santa Catarina and Parana. / O objetivo geral desta disserta??o ? analisar de forma explorat?ria a diversifica??o econ?mica e as causas da varia??o de emprego das microrregi?es da regi?o Sul do Brasil em dois per?odos 2002 e 2010. O estudo utiliza informa??es de emprego formal, obtido na Rela??o Anual de Informa??es Sociais (RAIS), para um conjunto de dos 25 subsetores do Instituto Brasileiro de Geografia e Estat?stica (IBGE), distribu?dos nas 94 microrregi?es sul-brasileiras. A investiga??o utiliza o ?ndice de entropia e de Herfindahl para calcular a diversidade para cada uma das microrregi?es sul-brasileiras, e avalia, em conjunto com uma decomposi??o do emprego por meio de t?cnica shift-share a relev?ncia dos efeitos nacional, setorial e competitivo sobre o crescimento do emprego regional. Por fim, realiza-se uma avalia??o por meio da taxonomia de Pavitt para verificar a relev?ncia de setores altamente tecnol?gicos para as microrregi?es. Os resultados indicam que o Efeito Setorial (ES) foi o fator preponderante para o crescimento do emprego regional. No geral, as microrregi?es analisadas apresentaram resultados positivos no Efeito Setorial (ES), com destaque para as microrregi?es do estado de Santa Catarina e do Paran?. O Efeito Nacional (EN) foi preponderante sobre a economia ga?cha.

Made available in DSpace on 2015-04-14T14:27:10Z (GMT). No. of bitstreams: 1 458454.pdf: 2993388 bytes, checksum: c8008f7b37ac7564557bbc999b5992be (MD5) Previous issue date: 2014-02-24 / This research constitutes the development of two papers that refer about Polo Naval de Rio Grande, as well as an introduction and a general conclusion. The main purpose is to analyze the amount of jobs to be created in COREDE SUL by level of education, in the time between 2006 and 2018 caused by the Polo Naval. It is noteworthy that 2006 is the year of commencement of construction of the first oil rig in that pole, and the year 2018 is scheduled for delivery later contracted to be built at Naval Polo platform. In the first paper an scenario is presented in the shipping industry in the world, and after, it presents an overview of the Polo Naval de Rio Grande. Then there is the COREDE SUL and bring some data from the municipalities of this region. Concluding the first part of the study, is presented the methodology for the preparation of the input-output matrix and thus presents the estimated MIP for COREDE SUL and how it was built. The input-output table product constructed in this study used data from the national headquarters, is derived from the RAIS and has the year 2006 as the period of analysis. The second paper presents the impact multipliers from the results found through the input-output matrix. Thus, estimates the jobs generated by Naval Pole between 2006 and 2018, which are calculated both by education level and by sector of the economy. Are also computed jobs by education level within sectors of the economy. Its structure shows the initial considerations and, as a result, investments in Polo Naval until the year 2018. The results show that there is a level of education that it is far behind the others in terms of jobs created. Among the sectors, some of them have the capacity to generate jobs well above the other, due to the low productivity per worker in specific areas, so that, to meet the demand of production determined by positive shocks to the economy a greater number is required workers. / Esta disserta??o se constitui na elabora??o de dois artigos que versam sobre a estrutura econ?mica do COREDE SUL e o P?lo Naval de Rio Grande. O objetivo principal ? analisar a quantidade de empregos a ser criado no COREDE SUL por n?vel de escolaridade, no espa?o de tempo entre 2006 e2018, atrav?s dos investimentos previstos no contexto da instala??o do P?lo Naval. A primeira parte da disserta??o ? constitu?da pela elabora??o da Matriz Insumo Produto -MIP para o COREDE SUL e a metodologia a qual foi empregada. A MIP constru?da nesse estudo utilizou os dados da matriz nacional de 2005. A base de dados usada deriva da Rela??o Anual de Informa??es Socias -RAIS e tem o ano de 2006 como per?odo de an?lise. O segundo artigo apresenta os multiplicadores de impacto associados ao perfil do mercado de trabalho por escolaridade a partir dos resultados encontrados atrav?s da MIP. Desta forma, s?o estimados os empregos gerados pelo P?lo Naval entre os anos de 2006 e 2018, os quais s?o calculados tanto por n?vel de escolaridade como por setor da economia. S?o computados, tamb?m, os empregos por n?vel de escolaridade dentro dos setores da economia. S?o considerados diferentes cen?rios de produtividade em paralelo ? introdu??o do P?lo Naval. Logo ap?s, s?o apresentados os resultados encontrados, em termos de empregos, por setor e escolaridade. Os resultados obtidos demonstram que n?o h? um n?vel de escolaridade que fique muito aqu?m dos demais em termos de empregos gerados. Entre os setores, alguns deles possuem capacidade de gera??o de vagas bem acima das demais, em decorr?ncia da baixa produtividade por trabalhador em ?reas espec?ficas, de maneira que, para suprir a demanda de produ??o determinada pelos choques positivos na economia, ? necess?rio um n?mero maior de trabalhadores.

Submitted by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-03-31T16:54:32Z No. of bitstreams: 1 TES_MARCEL_NEVES_MARTINS_COMPLETO.pdf: 5499979 bytes, checksum: 204bbb9ccec1909b288332abd1654cd8 (MD5) / Made available in DSpace on 2017-03-31T16:54:32Z (GMT). No. of bitstreams: 1 TES_MARCEL_NEVES_MARTINS_COMPLETO.pdf: 5499979 bytes, checksum: 204bbb9ccec1909b288332abd1654cd8 (MD5) Previous issue date: 2017-01-09 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / This thesis examines the construction of a popular sense of the 2014 World Cup, in Brazil, by the Zero Hora newspaper, from Porto Alegre, Rio Grande do Sul?s capital. The study overall objective is realize how Zero Hora built a popular sense for the mega-sports event, through folkcommunication in their texts, during the course of the competition in Brazil, from June 12 to July 13, 2014. Laurence Bardin?s ?content analysis? was adopted as research method to investigate the special section of Zero Hora, created to cover and thematize the World Cup, ?Jornal da Copa?, with daily circulation in the editions of ZH, from June 12 to July 14, 2014. The presented analysis resulted from exploring about 300 texts between news, articles and stories. The subjects were divided into six thematic areas ? ?games?, ?people?, ?Porto Alegre?, ?protagonists?, ?Brazilian Soccer Team? and ?police? ?, that guided the examination of Zero Hora?s communication strategies for the 2014 World Cup. The working hyphotesis, validated by the analysis, is that Zero Hora, as reference press, practiced a popular journalism, through a folkcommunication process. The research pointed that the popular sense of the 2014 World Cup intended by Zero Hora was the integration between the press and the event and the press with the newspaper?s readers, manly with the sports sections readers and soccer supporters, potential competition audience. Zero Hora sought to promote the integration of the local community as a whole to the mega-sports event by the engagement of its journalists in media coverage of the 2014 World Cup. The analysis shows the attempt of a society mental union. Our research is based on Luiz Beltr?o (1918- 1986) folkcommunication paradigm, positioning itself in the folkm?dia studies that explores the popular culture appropriation processes by the mass media. / Nesta tese problematiza-se a constru??o de um sentido popular da Copa do Mundo de 2014, no Brasil, pelo jornal Zero Hora, da cidade de Porto Alegre, capital do Rio Grande do Sul. O objetivo geral do estudo ? compreender como Zero Hora construiu, por meio da pr?tica da folkcomunica??o em seus textos, um sentido popular para o megaevento esportivo durante o per?odo de realiza??o da competi??o no pa?s, entre 12 de junho e 13 de julho de 2014. A metodologia utilizada ? a da ?an?lise de conte?do?, de Laurence Bardin. Investiga-se o ?Jornal da Copa?, caderno especial de Zero Hora, criado para a cobertura e a tematiza??o do acontecimento, com circula??o nas edi??es di?rias de ZH, do dia 12 de junho a 14 de julho de 2014. A an?lise apresentada ? produto da explora??o de cerca de 300 textos entre not?cias, reportagens e cr?nicas. As mat?rias foram distribu?das em seis eixos tem?ticos ? ?jogos?, ?gente?, ?Porto Alegre?, ?protagonistas?, ?Sele??o Brasileira? e ?pol?cia? ?, que orientaram o exame das estrat?gias comunicacionais de Zero Hora para a Copa de 2014. A hip?tese de trabalho, validada na an?lise, ? a de que Zero Hora, como ve?culo jornal?stico da imprensa de refer?ncia, praticou um jornalismo popular, atrav?s de um processo de folkcomunica??o. A investiga??o apontou que o sentido popular da Copa do Mundo de 2014, projetado por Zero Hora, foi o da integra??o da imprensa com o acontecimento e com o p?blico do jornal, principalmente com os leitores da se??o de Esportes e com fan?ticos ou apenas simpatizantes do futebol, audi?ncia potencial da competi??o. Zero Hora procurou promover a integra??o da comunidade local como um todo ao megaevento esportivo pelo engajamento de seus jornalistas na midiatiza??o da Copa de 2014. A an?lise explicita a tentativa de uma uni?o mental da sociedade. Nossa pesquisa se sustenta, em ?mbito epistemol?gico, no paradigma da folkcomunica??o, de Luiz Beltr?o (1918-1986), posicionando-se na linha de estudos da folkm?dia, que explora os processos de apropria??o da cultura popular pelos meios de comunica??o de massa.

Submitted by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-06-30T13:01:01Z No. of bitstreams: 1 DIS_JULIANA_RODRIGUES_RIBAS_PARCIAL.pdf: 387428 bytes, checksum: b203014febbd3b7b5366d994fd828441 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-06-30T13:01:09Z (GMT) No. of bitstreams: 1 DIS_JULIANA_RODRIGUES_RIBAS_PARCIAL.pdf: 387428 bytes, checksum: b203014febbd3b7b5366d994fd828441 (MD5) / Made available in DSpace on 2017-06-30T13:01:09Z (GMT). No. of bitstreams: 1 DIS_JULIANA_RODRIGUES_RIBAS_PARCIAL.pdf: 387428 bytes, checksum: b203014febbd3b7b5366d994fd828441 (MD5) Previous issue date: 2016-12-07 / This dissertation analyzes the contractual duties of employment relationship trough Law, Economics and Organization Theory, limiting the study to the employer?s duty to protect the employee and the employee from diligent work. This research, also, asks the conception of man in the Brazilian work contract seeks a more sophisticated answer considering the framework of the Consolidation of Labor Laws, explores the similarities and differences between the decision-making process of the employee and the employer, inquires the dogmas of conflict in Labor Law, that is presented since the 19th century, theme which inaugurates the First Chapter. Still, It presents the labor contract as the legal instrument that creates employment relations and legal subordination, investigating its subjects and refining legal rules about its existence, execution, termination and flexibility. This dissertation likewise ruminates on the duties in contractual labor relations, lists introductory notions of Economic Analysis of Labor Law, focusing on different economic perspectives of labor contracts, and defends the inclusion of ethical values into Economic Analysis of Law, focusing on the protection of employees in work accidents perception, environmental protection of work and human capital investment. Finally, this work ascertains the employee?s identification and commitment and its connection to diligence, the attempt to insert Brazilian Profit Participation in Labor Market and the connection between the job satisfaction and its turnover, thinking about the trust dynamics between the subjects in the employment relationships and about the influences of Brazil?s protectionist legal system; lastly, this work is concluded trough a proposal of reconciliation between work value and the pursuit of profit through the (re) adaptation of the decision-making process of the business organization. / Esta disserta??o analisa por meio do Direito, da Economia e da Administra??o os deveres contratuais da rela??o de emprego. Limita o estudo ao dever do empregador de prote??o ao empregado e do empregado de presta??o de trabalho diligente. Indaga a concep??o de indiv?duo no contrato de trabalho brasileiro. Procura uma resposta sofisticada ao enquadramento da Consolida??o das Leis do Trabalho. Explora as semelhan?as e diferen?as entre o processo decis?rio do empregado e do empregador. Questiona a dogm?tica do conflito no Direito do Trabalho, que trata a rela??o de emprego ainda sob a ?tica da luta de classes retratada no s?culo XIX, tema que inaugura o primeiro cap?tulo. Apresenta o contrato de trabalho como instrumento jur?dico gerador da rela??o de emprego e da subordina??o jur?dica. Investiga seus sujeitos e apura as regras legais sobre a sua exist?ncia, execu??o, extin??o e flexibiliza??o. Reflete sobre a ?tica de deveres na rela??o contratual laboral. Disp?e no??es introdut?rias acerca da An?lise Econ?mica do Direito do Trabalho, com foco na exposi??o de diferentes perspectivas econ?micas sobre a rela??o e o contrato de trabalho. Defende a inclus?o de valores ?ticos ? An?lise Econ?mica do Direito. Observa o dever de prote??o ao empregado pelo vi?s da percep??o de acidentes de trabalho, prote??o ao meio ambiente de trabalho e investimento em capital humano. Averigua a identifica??o e comprometimento do empregado e sua rela??o com a dilig?ncia, a tentativa de implanta??o de Participa??o de Lucros ou Resultados da Empresa no Brasil e a liga??o entre a satisfa??o do emprego e a rotatividade no emprego. Reflete acerca das din?micas de confian?a entre os sujeitos da rela??o de emprego e as influ?ncias de um sistema jur?dico protecionista. Conclui propondo a concilia??o entre a valoriza??o do trabalho e a persecu??o de lucros, por meio da (re)adequa??o do processo decis?rio da organiza??o empresarial.

Submitted by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-06-30T18:51:53Z No. of bitstreams: 1 TES_LUCIANO_DENARDIN_DE_OLIVEIRA_COMPLETO.pdf: 2504086 bytes, checksum: 9d81a7646c1c0d3d1e22b731e7fcd83f (MD5) / Made available in DSpace on 2017-06-30T18:51:53Z (GMT). No. of bitstreams: 1 TES_LUCIANO_DENARDIN_DE_OLIVEIRA_COMPLETO.pdf: 2504086 bytes, checksum: 9d81a7646c1c0d3d1e22b731e7fcd83f (MD5) Previous issue date: 2017-03-31 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / This work aims to understand the teacher-scientist interaction in a continuing education course named CERN Portuguese Language Teachers Programme under the perspective of the sociogenesis of knowledge theory by Ludwik Fleck. The research had a qualitative approach and focused on a case study. Teachers taking part in the course were interviewed and after that their discourse were interpreted according to the theoretical framework of the Discourse Analysis of French matrix. We understand that the structure of the CERN Portuguese Language Teachers Programme reflects a technical rationality and that a single thought collective regarding the thought style of particle physics is set. Scientists make up the esoteric circle, while the teachers make up the exoteric circle, what puts the stream of ideas in the intracollective order. The intracollective communication of ideas strenghts the thought style, so that after the experience in CERN teachers started to include aspects of particles physics in their classes and to promote activities of science popularization related to CERN. However, we have not noticed substantial changes in the teaching practices of the participants. Based on the theory of Fleck, we advocate that changes in the teaching practices happen in a considerable way if intercollective communications of ideas are privileged. In order to accomplish this goal, and contemplating the main guidelines of recent researches that investigated the teacher-scientist interaction in different contexts, we propose a model of teacher-scientist-researcher that involve three distinct thought collectives: the subject-based knowledge one, the professional education knowledge one, and the experiential knowledge one. / O objetivo deste trabalho foi compreender, ? luz da teoria da sociog?nese do conhecimento de Ludwik Fleck, a intera??o professor-cientista em um curso de forma??o continuada denominado Escola de F?sica do CERN. A pesquisa teve um car?ter qualitativo, enquadrando-se em um estudo de caso. Entrevistas foram realizadas com professores participantes do curso de forma??o supracitado e seus discursos interpretados segundo os pressupostos te?ricos da An?lise de Discurso da linha francesa. Compreendemos que a estrutura da Escola de F?sica do CERN reflete uma racionalidade t?cnica e que um ?nico coletivo de pensamento relativo ao estilo de pensamento da f?sica de part?culas ? estabelecido. Os cientistas integram o c?rculo esot?rico e os professores, o c?rculo exot?rico, fazendo com que o tr?fego de ideias seja da ordem intracoletiva. A circula??o intracoletiva de ideias fortalece o estilo de pensamento, de forma que ap?s a viv?ncia no CERN os professores passaram a inserir aspectos da f?sica de part?culas em suas aulas e a realizar atividades de divulga??o cient?fica relacionadas ao centro. Entretanto, n?o verificamos mudan?as significativas nas pr?ticas docentes dos participantes. Respaldado pela teoria fleckiana, defendemos que mudan?as nas pr?ticas docentes ocorrem de forma significativa se forem privilegiadas as circula??es intercoletivas de ideias. Para que essa situa??o seja alcan?ada e contemplando as principais diretrizes de pesquisas recentes que investigaram a intera??o professor-cientista em diferentes contextos, propomos um modelo de intera??o professor-cientista-pesquisador que envolva tr?s coletivos de pensamento distintos: dos saberes disciplinares, dos saberes da forma??o profissional e dos saberes experienciais.

Submitted by PPG Economia do desenvolvimento (economia-pg@pucrs.br) on 2017-12-12T17:00:04Z No. of bitstreams: 1 JORGE_LUIS_TONETTO_DIS.pdf: 2973041 bytes, checksum: eb8a94f5e93cbbed89b22017d14fbb38 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-12-19T11:23:30Z (GMT) No. of bitstreams: 1 JORGE_LUIS_TONETTO_DIS.pdf: 2973041 bytes, checksum: eb8a94f5e93cbbed89b22017d14fbb38 (MD5) / Made available in DSpace on 2017-12-19T11:26:39Z (GMT). No. of bitstreams: 1 JORGE_LUIS_TONETTO_DIS.pdf: 2973041 bytes, checksum: eb8a94f5e93cbbed89b22017d14fbb38 (MD5) Previous issue date: 2017-11-20 / This research was directed at health economics, seeking to verify if municipal public health expenditures have an influence on the variation of the health indicators of each municipality, specifically in the indicators IFDM-Health (Firjan Index of Municipal Development) and Potential Years of Lost Life. First, there was a broad review of the national and international literature, with emphasis on the regulatory framework, health expenditures, financing models and efficiency. The period analyzed was from 2005 to 2014 for the Potential Years of Lost Lifeand from 2005 to 2013 for the IFDM-Health. All Brazilian municipalities that had available indicators were analyzed, and the Potential Years of Lost Lifewere calculated for each municipality per year, with the limit of 70 years as a potential life. The expenditures data of the municipalities were extracted from the National Treasury Secretariat and were inflated by the IPCA until 2014. The databases of IBGE, Datasus and SNIS were also used. This basis was adequate to its nomenclature and worked to be used in an econometric program for panel analysis. Four models were developed, two for each dependent variable, differentiated by the use of the health function and alternatively by the sub-functions of basic care and hospital care. The results pointed in different directions. For all models, analyzing the periods of each management over time, suggests an improvement in efficiency. Population size has significance for the variable Potential Years of Lost Life, and the municipal expenditure function was also significant in the quadratic and cubic forms, and only the basic care subfunction showed to be relevant, allowing an optimal point to be determined, from where the efficiency process started. For the IFDM-Health, the variable physicians was significant and the signal as expected. The municipal expenditures on the health function were also relevant in the quadratic form, indicating a point where it becomes inefficient. In health subfunctions expenditures, it was possible to find an optimization point for both. / Esta pesquisa foi direcionada a economia da sa?de, buscando verificar se os gastos de sa?de p?blicos municipais t?m influ?ncia na varia??o dos indicadores de sa?de de cada munic?pio, especificamente nos indicadores IFDM-Sa?de (?ndice Firjan de Desenvolvimento Municipal) e Anos potenciais de vida perdido (APVP). Primeiramente foi realizada ampla revis?o da literatura nacional e internacional, com ?nfase no marco regulat?rio, nos gastos em sa?de, nos modelos de financiamento e no quesito efici?ncia. A despesa em sa?de em geral tem aumentado sua relev?ncia nos or?amentos, incluindo gastos p?blicos e privados. A busca pela efici?ncia tem pautado a maioria dos pa?ses. O per?odo analisado foi de 2005 a 2014 para o APVP e de 2005 a 2013 para o IFDM-Sa?de. Foram analisados todos os munic?pios brasileiros que possu?am indicadores dispon?veis, e para o APVP foi calculado para cada munic?pio por ano, tendo como limite 70 anos como potencial de vida. Os dados de gasto dos munic?pios foram extra?dos da Secretaria do Tesouro Nacional e foram inflacionados pelo IPCA at? 2014. Utilizou-se ainda as bases do IBGE, do Datasus e do SNIS. Essa base foi adequada a sua nomenclatura e trabalhada para ser utilizada em programa econom?trico para an?lise em painel. Foram desenvolvidos quatro modelos, dois para cada vari?vel dependente, diferenciados pelo uso da fun??o sa?de e alternativamente pelas subfun??es aten??o b?sica e assist?ncia hospitalar. Os resultados apontaram em diferentes dire??es. Para todos os modelos, analisado os per?odos de cada gest?o ao longo do tempo, sugere uma melhora na efici?ncia. O tamanho populacional tem signific?ncia para a vari?vel APVP, e o gasto municipal na fun??o sa?de se mostrou significante tamb?m nas formas quadr?ticas e c?bicas, e apenas a subfun??o aten??o b?sica mostrou-se relevante, permitindo apurar um ponto de otimiza??o, a partir de onde inicia-se processo de efici?ncia. Para a vari?vel IFDM-Sa?de mostrou-se significante a vari?vel m?dicos e com sinal esperado. Quanto aos gastos municipais na fun??o sa?de, este foi relevante tamb?m na forma quadr?tica, indicando ponto onde torna-se ineficiente. Nas subfun??es sa?de foi poss?vel encontrar ponto de otimiza??o para ambas.

Submitted by PPG Biologia Celular e Molecular (bcm@pucrs.br) on 2018-03-15T12:31:20Z No. of bitstreams: 1 Tese Doutorado Adilio.pdf: 2662669 bytes, checksum: 73c86d6d555c94d57c1f0714b5c2ccbc (MD5) / Approved for entry into archive by Tatiana Lopes (tatiana.lopes@pucrs.br) on 2018-03-23T11:44:45Z (GMT) No. of bitstreams: 1 Tese Doutorado Adilio.pdf: 2662669 bytes, checksum: 73c86d6d555c94d57c1f0714b5c2ccbc (MD5) / Made available in DSpace on 2018-03-23T11:52:37Z (GMT). No. of bitstreams: 1 Tese Doutorado Adilio.pdf: 2662669 bytes, checksum: 73c86d6d555c94d57c1f0714b5c2ccbc (MD5) Previous issue date: 2018-03-02 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Tuberculosis (TB), caused mainly by Mycobacterium tuberculosis, is an infectious disease responsible for a significant number of deaths worldwide. IQG-607 is an analog of isoniazid (INH). According to several experiments carried out by our research group, IQG-607 showed both in vitro and in vivo anti-TB activity. Initial studies showed that the compound INCT-TB551 (a quinoline derivative) also presents in vitro anti-TB activity. The aim of this study was to develop analytical methods by high performance liquid chromatography (HPLC-UV) for quantification of IQG-607 and INCT-TB551 in mice plasma, and therefore to perform pharmacokinetic studies. The analytical method for the determination of IQG-607 in mice plasma showed linearity (r = 0.9992) in 0.5? 50 ?g/mL concentration range. Intra- and inter-day precision was < 15%, and the recovery ranged from 92.07 to 107.68%, showing that the method provides a precise and accurate analysis of the compound. In addition, IQG-607 was stable in plasma for at least 30 days at ?80 ?C, and after plasma processing, for 4 h in the auto-sampler (6 ?C) and maintained on ice (recovery > 85%). The applicability of the method for pharmacokinetic studies was determined after intravenous (i.v.) and oral (fasted and fed conditions) administrations to mice. IQG-607 levels in plasma were quantified at time points for up to 2.5 h. A short half-life (t1/2) (1.14 h), a high clearance (CL) (3.89 L/h/kg), a moderate volume of distribution at steady state (Vdss, 1.22 L/kg), were observed after i.v. (50 mg/kg) administration. Similar results were obtained for oral administration (250 mg/kg) under fasted and fed conditions. The oral bioavailability (F), approximately 4%, was not altered by feeding. Plasma protein binding was 88.87 ? 0.9%. Recently, experiments in mice infected with M. tuberculosis have shown that the compound INCT-TB551 has no in vivo activity, unlike previous in vitro activity studies. An analytical method was developed for the determination of INCT-TB551 in mice plasma to assess compound absorption, if any, after oral administration. The analytical method presented linearity from 0.1-10 ?g/mL (r = 0.9999). After development of the analytical method, the compound was orally administered in mice and the plasma levels were quantified at time points for up to 1 h. The compound INCT-TB551 was detected in the plasma of animals, which indicated that INCT-TB551 was absorbed. Although absorbed when orally administered, the compound is not exhibiting activity against M. tuberculosis in this animal model. This finding may be associated with the formation of inactive metabolites and/or the plasma concentration of INCT-TB551 achieved may be inadequate to exert its therapeutic effect. However, these points require further investigations. The protocols described here may serve as support to initiate pharmacokinetic studies of promising compounds, collaborating to advance in earlier stages of drug development. / A tuberculose (TB) ? uma doen?a infecto-contagiosa, causada principalmente pelo Mycobacterium tuberculosis, respons?vel por um n?mero consider?vel de mortes em todo o mundo. O composto IQG-607 ? um an?logo da isoniazida (INH) que, de acordo com diversos experimentos realizados pelo grupo de pesquisa envolvido no seu estudo, apresenta atividade anti-TB in vitro e in vivo. Estudos iniciais do mesmo grupo demonstraram que o composto INCT-TB551 (um derivado quinol?nico) tamb?m apresenta promissora atividade anti-TB. O objetivo deste estudo foi desenvolver metodologias anal?ticas por cromatografia l?quida de alta efici?ncia (CLAE-UV) para a quantifica??o do composto IQG-607 e do INCT-TB551, em plasma de camundongos, para a realiza??o de estudos de farmacocin?tica. O m?todo anal?tico para a determina??o do composto IQG-607 em plasma de camundongos apresentou linearidade (r = 0.9992) na faixa de 0.5?50 ?g/mL. Os valores de precis?o intra e interensaio (CV < 15%) e de recupera??o (92.07-107.68%) demonstram que o m?todo ? preciso e exato para a an?lise do composto. Al?m disso, o IQG-607 se mostrou est?vel no plasma por at? 30 dias, quando armazenado no freezer -80 ?C, e est?vel ap?s o tratamento da amostra do plasma, por at? 4 horas (h) na bancada (gelo) e no autosampler do equipamento (6 ?C). A aplicabilidade do m?todo anal?tico para o estudo de farmacocin?tica foi determinada ap?s a administra??o i.v. e oral em camundongos (animais em jejum e animais alimentados). As concentra??es plasm?ticas de IQG-607 foram quantificadas por at? 2,5 h ap?s a administra??o nos animais. Quando administrado pela via i.v. foi observado um tempo de meia vida (t1/2) curto (1,14 h), elevado clearance (CL) (3,89 L/h/kg), e um moderado volume de distribui??o (Vdss) (1,22 L/kg). Resultados similares foram obtidos ap?s a administra??o oral (250 mg/kg) em camundongos que estavam em jejum ou alimentados. A biodisponibilidade oral (F) foi de aproximadamente 4 %, valor que n?o foi alterado pela alimenta??o. A taxa de liga??o a prote?nas plasm?ticas do IQG-607 ? de aproximadamente 88 ? 0.9%. Experimentos recentes em camundongos infectados com M. tuberculosis demonstraram que o composto INCT-TB551 n?o apresentou atividade neste modelo in vivo, ao contr?rio dos estudos de atividade in vitro realizados anteriormente. Um m?todo anal?tico para a determina??o do composto INCT-TB551 em plasma de camundongos foi desenvolvido para avaliar se o composto estava sendo absorvido ap?s a administra??o oral. O m?todo anal?tico apresentou linearidade na faixa de 0.1-10 ?g/mL (r = 0.9999). Ap?s o m?todo ter sido padronizado, o composto foi administrado por via oral em camundongos, e as concentra??es plasm?ticas foram quantificadas por at? 1 h ap?s a administra??o. O composto INCT-TB551 foi detectado no plasma dos animais, indicando que estava sendo absorvido. Apesar de absorvido quando administrado por via oral, o composto n?o est? apresentando atividade contra M. tuberculosis neste modelo animal, o que pode estar relacionado, por exemplo, com a forma??o de metab?litos inativos e/ou ainda, o n?vel plasm?tico atingido pode ser inadequado para que o composto consiga exercer o seu efeito terap?utico, e isto precisa ser melhor investigado. Os protocolos apresentados neste trabalho poder?o servir como suporte para estudos de farmacocin?ticoa de compostos que se apresentam promissores, colaborando para o avan?o nas etapas necess?rias para o desenvolvimento de poss?veis f?rmacos.

Submitted by PPG Ci?ncias Criminais (ppgccrim@pucrs.br) on 2018-04-19T12:43:48Z No. of bitstreams: 1 PAULA GARCIA - Disserta??o.pdf: 1184867 bytes, checksum: aac9e969062819d8ee54748642143c62 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2018-05-07T19:12:53Z (GMT) No. of bitstreams: 1 PAULA GARCIA - Disserta??o.pdf: 1184867 bytes, checksum: aac9e969062819d8ee54748642143c62 (MD5) / Made available in DSpace on 2018-05-07T19:19:33Z (GMT). No. of bitstreams: 1 PAULA GARCIA - Disserta??o.pdf: 1184867 bytes, checksum: aac9e969062819d8ee54748642143c62 (MD5) Previous issue date: 2018-01-10 / This dissertation is inserted in the research line ?Violence, Crime and Public Safety?, under the guidance of Prof. Dr. Ricardo Jacobsen Gloeckner, and has as objective the analisys of the official discourse about police violence in the city of Porto Alegre. At first, it was made a research to collect data on police violence in Brazil in order to demonstrate the relevance of the problem, and also a demonstration about some sociological and criminological contributions that could help on the understanding of the topic. Secondly, it was showed the data collected during the empirical research from the analysis of some police investigations and criminal prosecution of homicide crimes practiced by police officers. Finally, the methodology of discourse analysis was used to demonstrate the regularities that are present in the discourse of the police authorities and public prosecutors in the specific cases of lethal police violence that were analyzed here, using the subcultural theory and the neutralization theory to help on the comprehension of the topic. / A presente disserta??o est? inserida na linha de pesquisa ?Viol?ncia, Crime e Seguran?a P?blica?, sob a orienta??o do Prof. Dr. Ricardo Jacobsen Gloeckner, e tem como objeto de an?lise o discurso oficial acerca da viol?ncia policial na cidade de Porto Alegre. Nesse sentido, procurou-se realizar, primeiramente, um apanhado acerca dos n?meros referentes ? viol?ncia policial no Brasil, com a finalidade de demonstrar a relev?ncia do problema, bem como uma apresenta??o referente a algumas contribui??es sociol?gicas e criminol?gicas capazes de auxiliar na compreens?o do tema. Em um segundo momento, foram apresentados os dados coletados na pesquisa emp?rica, provenientes da an?lise de alguns inqu?ritos policiais e processos criminais de crimes de homic?dios praticados por policiais militares. Por fim, foi utilizada a metodologia de an?lise do discurso para demonstrar as regularidades presentes no discurso das autoridades policiais e dos representantes do Minist?rio P?blico nos casos de viol?ncia policial letal analisados, buscando na teoria das subculturas criminais e na teoria das t?cnicas de neutraliza??o algumas possibilidades de compreens?o do tema.

Submitted by Ricardo Cedraz Duque Moliterno (ricardo.moliterno@uefs.br) on 2016-10-24T21:28:55Z No. of bitstreams: 1 Disserta??o, DOC.pdf: 5943433 bytes, checksum: 353ade7c41c9060be4ef463f0cfd3f12 (MD5) / Made available in DSpace on 2016-10-24T21:28:55Z (GMT). No. of bitstreams: 1 Disserta??o, DOC.pdf: 5943433 bytes, checksum: 353ade7c41c9060be4ef463f0cfd3f12 (MD5) Previous issue date: 2016-03-23 / Funda??o de Amparo ? Pesquisa do Estado da Bahia - FAPEB / Revista Ra?a Brasil is a magazine destined to the black audience and it aims to rescue the self steam of the black race, in order to rescue it, the magazine publishes in its contents, media highlights intending to show the idea that it is possible for the black people to move upward in society too. The magazine was launched in trade environment in 1996, among other magazines that did not succeed, Revista Ra?a Brasil is the one which is most sedimented. This master?s thesis aims to analyze discursive aspects about the black woman, in the magazine mentioned, mainly focusing on reflection about the female aspect. Based on the Discourse Analysis which seeks in speaking flaw and in the silencing possible senses and it is based on the analysis of historical and ideological constructions which constitute the utterance. It will be analyzed the discourses that move in the magazine trying to show that even a magazine which aims to value the black beauty, it utters discourses that reinforce the non-acceptance of black people as potential beings who have their own beauty. It is possible to find in the magazine discourses which ignore the black beauty as legitimate and black women represented based on European beauty standards. It is possible to query, through Revista Ra?a Brasil how black women discursive construction happens, being, thus relevant for the comprehension about what means being a woman as well as which positions she occupies. This research is theoretically based on French Discourse Analysis, specifically studies of Orlandi and P?cheux (1997). Thus, some categories such as ?already-said? marks about black women which constitute the interdiscourse, and ideological and discursive formations in which black women are represented in the magazine. / A Revista Ra?a Brasil, destinada ao p?blico negro, visa resgatar a auto-estima da ra?a negra. Para tanto, a Revista traz em seu conte?do, destaques midi?ticos com o intuito de levar a esse p?blico a ideia de que o negro tamb?m pode ascender, socialmente. Lan?ada em 1996, a Revista Ra?a Brasil, no ?mbito comercial, ? a circula??o mais sedimentada em detrimento de outras, que n?o obtiveram sucesso. Esta disserta??o pretende analisar aspectos discursivos sobre a mulher negra, na revista em quest?o, tendo como foco as reflex?es sobre o feminino. Partindo da An?lise do Discurso que busca na falha que fala e no silenciamento, os poss?veis sentidos e baseia-se na an?lise das constru??es hist?ricas e ideol?gicas que constituem o enunciado - ser?o analisados os discursos que circulam nessa revista tentando mostrar que mesmo uma revista de valoriza??o da ra?a negra, acaba proferindo discursos que refor?am a n?o aceita??o do negro enquanto ser de potencial, com suas belezas pr?prias. ? poss?vel encontrar, nessa revista, discursos que desconsideram a beleza negra como leg?tima, e em que as negras s?o representadas a partir de padr?es de beleza europeus. Atrav?s da Revista Ra?a Brasil ? poss?vel inquirir como ocorre a constru??o discursiva da mulher negra, sendo, portanto, importante para a compreens?o do que ? ser mulher e de quais posi??es ela ocupa. O escopo te?rico dessa pesquisa est? centrado na An?lise de Discurso de Linha Francesa, tendo como base os estudos de Orlandi e P?cheux, 1997. Desse modo, algumas categorias tais como as marcas dos j? ditos sobre a mulher negra que constituem o interdiscurso, bem como as forma??es discursivas e ideol?gicas nas quais as mulheres negras s?o representadas na Revista.

Submitted by Ricardo Cedraz Duque Moliterno (ricardo.moliterno@uefs.br) on 2018-02-01T21:55:58Z No. of bitstreams: 1 Dissertac?o Cl?udia M P Boa Morte.pdf: 3690521 bytes, checksum: 079275279cb2559804cb37bff9ee0728 (MD5) / Made available in DSpace on 2018-02-01T21:55:58Z (GMT). No. of bitstreams: 1 Dissertac?o Cl?udia M P Boa Morte.pdf: 3690521 bytes, checksum: 079275279cb2559804cb37bff9ee0728 (MD5) Previous issue date: 2017-02-16 / What are the senses? effects generated on black women from the notion of nappy hair on hair-focused Facebook communities? This questioning drives this research, which seeks to answer the question under P?cheux?s Discourse Analysis theoretical contribution. The proposal is to present the aspects related to the concepts of senses, ideological formation, discursive formation, interdiscourse, discursive memory and silencing, elements that are intrinsic to the notion of discourse and to the subjects that are discussed on Facebook communities. Black women occupy the place of the discourse?s object, which produces and reproduces senses based on certain conditions of production. Thus, on Facebook there is a competition between different discursive formations, allowing the resumption, resignification and rupture of historically constructed meanings about black women and beauty standards. Through the posts and comments on chosen communities, it was analyzed how social, historical and ideological issues permeate the discourses about the black women subject and the process of acceptance and / or rejection of nappy hair in the virtual environment, which reflects, in many aspects, what is present in the real environment. Senses that are attributed to hair do not refer only to the aesthetic, but to the way the image of the black women was socially constituted. / Quais os efeitos de sentidos gerados sobre a mulher negra a partir da no??o de cabelos crespos nas comunidades do facebook, voltadas para a tem?tica cabelo? Este questionamento fundamenta esta pesquisa, que busca responder ? pergunta por meio do aporte te?rico a An?lise de Discurso Pecheutiana. A proposta ? apresentar os aspectos relacionados aos conceitos de sentidos, forma??o ideol?gica, forma??o discursiva, interdiscurso, mem?ria discursiva e silenciamento, elementos que s?o intr?nsecos ? no??o de discurso e aos sujeitos que discursivizam nas comunidades do facebook. As mulheres negras, ocupam o lugar de sujeito do discurso, que produzem e reproduzem sentidos pautados em determinadas condi??es de produ??o. Assim, no facebook ocorre embate entre forma??es discursivas distintas, permitindo a retomada, ressignifica??o e rompimento de sentidos constru?dos historicamente sobre mulher negra e padr?o de beleza. Atrav?s das postagens e coment?rios nas comunidades selecionadas, analisou-se como as quest?es sociais, hist?ricas e ideol?gicas permeiam os discursos a respeito do sujeito-mulher negra e o processo de aceita??o e/ou rejei??o dos cabelos crespos no ambiente virtual, que reflete, em in?meros aspectos, o que est? presente no ambiente real. Aos cabelos s?o atribu?dos sentidos que n?o se referem apenas ? est?tica, mas ? forma como a imagem da mulher negra foi constitu?da socialmente.