O Peptídeo Liberador de Gastrina é um peptídeo neuroendócrino que tem importante atividade como fator de crescimento em diferentes tipos de cânceres. A expressão aumentada do GRP tem sido documentada em várias neoplasias, e estudos sobre uso terapêutico do bloqueio dos receptores do GRP (GRPR) têm apresentado resultados promissores. Nosso objetivo foi determinar a expressão do GRPR no carcinoma epidermóide de canal anal e discutir suas potenciais aplicações clínicas. Foi realizada análise imunoistoquímica em blocos de parafina com amostras tumorais de 35 pacientes com câncer anal. Como grupo controle não maligno, analisamos 24 amostras de tecidos anais (anatomopatológicos de hemorroidectomias). A expressão do GRPR foi avaliada utilizando uma abordagem semi-quantitativa de acordo com a intensidade e distribuição da coloração. Todos os tecidos analisados, com exceção de uma amostra controle, apresentaram imunoexpressão positiva do GRPR. O GRPR teve forte expressão em 54% das amostras tumorais e em somente 12% das amostras do grupo controle (P < 0.003). Nos tumores, o receptor demonstrou um padrão de distribuição difuso e homogêneo Em contraste, as amostras do grupo controle apresentaram um padrão de coloração focal restrito à metade mais profunda da camada basal do epitélio. Em conclusão, demonstramos que o GRPR é altamente expresso no carcinoma epidermóide do canal anal, o que sugere que este receptor possa desempenhar um papel na carcinogênese anal. Nossos resultados fornecem uma base para a exploração do receptor de gastrina como um alvo diagnóstico e terapêutico no carcinoma anal.

Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2017-10-03T19:18:17Z No. of bitstreams: 1 2016 - Jos? Marcelo Velloso de Oliveira.pdf: 4277827 bytes, checksum: 283210b4b641db9ae05f5439a98b2dfc (MD5) / Made available in DSpace on 2017-10-03T19:18:17Z (GMT). No. of bitstreams: 1 2016 - Jos? Marcelo Velloso de Oliveira.pdf: 4277827 bytes, checksum: 283210b4b641db9ae05f5439a98b2dfc (MD5) Previous issue date: 2016-08-03 / There are several factors that hinder the work development of mathematics teachers in basic education. Among them is the inappropriate use of smartphones / tablets for students, among the academic activities. These mobile devices, for their variety of prices are available for everyone, and because of that they are present in almost all parts of the day. Smartphones / tablets today have thousands of applications for many different uses, no matter the operational system they use. On the other hand, in the educational field, these devices are not yet part of the classroom routine productively; on the opposite, are elements of distraction to the students. In an attempt to take advantage of this feature as a pedagogical tool for the teaching of math, taking advantage of the presence of the students equipments in classes, came the proposal to create and use an application called AGA, which runs on the Android operating system, for the use in classes that addressed primary topics of analytic geometry, such as marking points in the Cartesian point and distance between points on the plane. It is important to highlight that among the available operating systems, Android dominates the smartphone / tablet market. The building application for this research was developed through an integrated development environment MIT (Massachusetts Institute of Technology). It is a simple and interactive way to build applications for the Android operating system for mobile devices. The use of the application in mathematics lessons took place in a class of the third year of high school in a state school, located in Serop?dica City. For the assessment of the experiment, they were applied in the research group, tests before and after the activities, addressing the working content and motivation to study mathematics. Such tests allowed the analysis of the impact of the work developed in class and efficiency of the construction and use of the AGA. / Existem diversos fatores que dificultam o desenvolvimento do trabalho dos professores de matem?tica na educa??o b?sica. Dentre eles, est? o uso inapropriado dos smartphones/ tablets por discentes, em meio ?s atividades acad?micas. Estes aparelhos m?veis, por suas variedades de pre?os, est?o dispon?veis para todos os p?blicos, de modo que est?o presentes em quase todos os momentos do dia. Os smartphones/ tablets atuais disp?em de milhares de aplicativos para as mais diversas utiliza??es, independente do sistema operacional que utilizam. Por outro lado, no campo educacional, aparelhos como estes ainda n?o fazem parte da rotina de sala de aula de forma produtiva; ao contr?rio, s?o elementos de distra??o para os discentes. Em uma tentativa de aproveitar esse recurso como ferramenta pedag?gica para o ensino de matem?tica, aproveitando a presen?a dos equipamentos dos alunos nas aulas, surgiu a proposta de cria??o e de uso de um aplicativo, denominado AGA, o qual funciona no sistema operacional Android, para utiliza??o em aulas que abordassem t?picos preliminares de Geometria Anal?tica, tais como marca??o de pontos no plano cartesiano e dist?ncia entre pontos no plano. Vale destacar que, dentre os sistemas operacionais dispon?veis, o Android domina o mercado de smartphones/ tablets. A constru??o do aplicativo para esta pesquisa foi desenvolvida atrav?s de um ambiente de desenvolvimento integrado do MIT (Massachussetts Institute of Tecnology). Trata-se de uma forma simples e interativa de se construir aplicativos para dispositivos m?veis de sistema operacional Android. A utiliza??o do aplicativo em aulas de Matem?tica ocorreu em uma turma de terceiro ano do ensino m?dio de uma escola da rede estadual, localizada do munic?pio de Serop?dica. Para efeitos de avalia??o da experi?ncia, foram aplicados, na turma pesquisada, testes antes e depois das atividades, abordando o conte?do trabalhado e a motiva??o para estudar matem?tica. Tais testes permitiram as an?lises do impacto do trabalho desenvolvido na turma e da efic?cia da constru??o e utiliza??o do AGA.

Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2018-05-09T18:11:56Z No. of bitstreams: 1 2016 - Adriano Lima de Souza.pdf: 2192319 bytes, checksum: 807ca78fcd7f6e3b189d186b495a2ac9 (MD5) / Made available in DSpace on 2018-05-09T18:11:56Z (GMT). No. of bitstreams: 1 2016 - Adriano Lima de Souza.pdf: 2192319 bytes, checksum: 807ca78fcd7f6e3b189d186b495a2ac9 (MD5) Previous issue date: 2016-11-03 / The understanding of the brazilian soul complexity arouses the interest of psychologists and researchers aligned with the theoretical framework of analytical psychology of Carl Gustav Jung. So this is the development of research on the african-Brazilian religious diversity. Genuinely Brazilian, Umbanda is marked by syncretism of indigenous, african traditions, catholicism and the spiritism of Kardec. It is remarkable the integration, on the mythical plan in his own Pantheon, of marginalized members categories. In this sense, Z? Pelintra is the direct representative of the Rio?s trickery which emerged in the early of the twentieth century. Historical fact of this period which we highlight, are the intense removals (remocao de que???) known as the "put-to-low" of Pereira Passos. It is in this period that the figure of the "trickster" appears circulating for several areas of the city. In 1808, with the arrival of the Royal Family and the Portuguese Court in Brazil, the Law of Pensions was established to ensure the Portuguese nobles the right to request a house to bring them satisfaction. During this period, the groups of ?capoeira? as well as tricksters, occupied the city on their own way. In the XXI century, Rio de Janeiro lives a new process of change in the urban and social space, as in the previous arbitrary removals which were part of history. Hence, Jung understands that the unconscious processes and the conscious activity generate psychic compensation ruled by tangible and / or abstract expressions. So here we have the following questions: what material and psychological impact urban removals are causing in the city of Rio de Janeiro? If removals reveal aspects of the class struggle present in the city, then we can consider the trickster and Z? Pelintra phalanx as individual and collective unconscious compensations? In our research we recognize that the image of Z? Pelintra reveals the psychological aspects related to the personification of a cultural complex. / A compreens?o da complexidade da alma brasileira desperta o interesse de psic?logos e pesquisadores alinhados com o referencial te?rico da psicologia anal?tica de Carl Gustav Jung. Logo, ? presente o desenvolvimento de pesquisas sobre a diversidade religiosa afro-brasileira. Genuinamente brasileira, a umbanda ? marcada pelo sincretismo das tradi??es ind?genas, africanas, o catolicismo e espiritismo de Kardec. ? marcante a integra??o, no plano m?tico, em seu Pante?o, de categorias s?cias marginalizadas. Nesse sentido, Z? Pelintra ? o representante direto da malandragem carioca surgida no come?o do s?culo XX. Fato hist?rico desse per?odo, que destacamos, s?o as intensas remo??es conhecidas como o ?bota-a-baixo? de Pereira Passos. ? nesse per?odo que a figura do ?malandro? aparece circulando por v?rias ?reas da cidade. Em 1808, com a chegada da Fam?lia Real e a Corte Portuguesa no Brasil, foi institu?da a Lei das Aposentadorias para garantir aos nobres portugueses o direito de requisitar uma moradia que lhe trouxesse satisfa??o. Nesse per?odo, as maltas de capoeira e assim como os malandros, ocupavam a cidade a sua maneira. J? no s?culo XXI, o Rio de Janeiro vive novo processo de mudan?a no espa?o urbano e social, assim como nos anteriores as remo??es arbitrarias fizeram parte da hist?ria. Jung compreende que os processos inconscientes e a atividade consciente geram compensa??es ps?quicas pautadas em manifesta??es tang?veis e/ou abstratas. Ent?o, aqui temos os seguintes questionamentos: qual impacto material e psicol?gico as remo??es urbanas est?o causando na cidade do Rio de Janeiro? Se as remo??es revelam aspectos da luta de classes, presentes na cidade, ent?o, podemos considerar que o malandro e a falange de Z? Pelintra s?o compensa??es inconscientes individuais e coletivas? Em nossa pesquisa reconhecemos que a imagem de Z? Pelintra revela e, ao mesmo tempo, desvela aspectos psicol?gicos que apontam para a personifica??o de um complexo cultural.

Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2018-08-15T17:49:37Z No. of bitstreams: 1 2017 - Amanda Ayres.pdf: 950686 bytes, checksum: 1254386698215a2837a7189f872171e6 (MD5) / Made available in DSpace on 2018-08-15T17:49:37Z (GMT). No. of bitstreams: 1 2017 - Amanda Ayres.pdf: 950686 bytes, checksum: 1254386698215a2837a7189f872171e6 (MD5) Previous issue date: 2017-08-31 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / This research aims at the influences of religion before death, interviewing practitioners of Catholicism, Candombl? and indigenous Guarani-Mby? ethnic group, to build a sense of the subject using the theoretical framework of Analytical Psychology by Carl Gustav Jung, with other areas of human knowledge, such as: tanatology, history, sociology, anthropology, biology, theology, and also the knowledge of the respective practitioner. To compose a research, five practitioners / supporters of Candombl? (Il? Omiojuar? - Nova Igua?u, RJ), Catholicism (S?o Sebasti?o, Barra Mansa, RJ) and Guarani-Mby? religion (Sapukai Village, Angra dos Reis, RJ), making a total of fifteen participants. From the knowledge collected in the research field, through the application of a semi-structured interview and using the resources of symbolic-archetypal processing, it was noticed that the influence of religiosity before death is manifested in many ways according to each religious group. So, the notion of the continuity of life, the value of ancestry, the hope of going to a better place, the maintenance of health and identity, among other aspects, were influences understood in the project. As a research that prioritized the context and the understanding of symbols in the collective, the project presents narratives about the beliefs related to death in the interaction and individual-group influence, resulting in the perception of the experience of death within the myths and rites of each religion researched. Thus, the influences of religiosity before death in each researched collective context were highlighted, highlighting their particularities as a religious practice, and the archetypal potential of death, as transmutation, transformation and renewal through the continuity of life, beyond the physical dimension / Este trabalho tem como objetivo compreender influ?ncias da religiosidade diante da morte, entrevistando praticantes do Catolicismo, do Candombl? e da etnia ind?gena Guarani-Mby?, para montar uma compreens?o da tem?tica, utilizando o referencial te?rico da Psicologia Anal?tica de Carl Gustav Jung, em conjunto com outras ?reas do conhecimento humano, como: tanatologia, hist?ria, sociologia, antropologia, biologia, teologia, bem como o conhecimento do respectivo praticante. Para compor a pesquisa, foram entrevistados cinco praticantes/adeptos do Candombl? (Il? Omiojuar? ? Nova Igua?u, RJ), do Catolicismo (Matriz de S?o Sebasti?o, Barra Mansa, RJ) e da religi?o Guarani-Mby? (Aldeia Sapukai, Angra dos Reis, RJ), perfazendo o total de quinze participantes. A partir do saber colhido na pesquisa de campo, com a aplica??o de uma entrevista semiestruturada e utilizando os recursos do processamento simb?lico-arquet?pico, observou-se que a influ?ncia da religiosidade diante da morte se manifesta de muitas formas, de acordo com cada grupo religioso. Assim, a no??o da continuidade da vida, o valor da ancestralidade, a esperan?a de ir para um lugar melhor, a manuten??o da sa?de e da identidade, entre outros aspectos, foram influ?ncias compreendidas no trabalho. Por ser uma pesquisa que priorizou o contexto e a compreens?o de s?mbolos na coletividade, o trabalho apresenta narrativas sobre as cren?as relacionadas ? morte na intera??o e influ?ncia indiv?duo-grupo, resultando na percep??o da viv?ncia da morte dentro dos mitos e ritos de cada religi?o pesquisada. Desse modo, foram destacadas as influ?ncias da religiosidade diante da morte em cada contexto coletivo pesquisado, evidenciando suas particularidades, enquanto pr?tica religiosa, e o potencial arquet?pico da morte, enquanto transmuta??o, transforma??o e renova??o atrav?s da continuidade da vida, para al?m da dimens?o f?sica

<p>Chromosomal abnormalities are defined as changes in the chromosome structure and fall in one of two categories. The first category is numerical alterations while the second category consists of structural abnormalities. Structural chromosomal abnormalities do not always interrupt genes in order to cause disease. They can also affect gene expression by separating a gene and its promoter element from distant regulatory elements. We have used characterisation of structural chromosomal abnormalities to identify the genetic bases for several congenital disorders.</p><p>In papers I-III, we have applied molecular characterisation of chromosomal translocations in order to identify candidate genes involved in mental retardation, hypospadias and anal malformation and premature ovarian failure. In paper I, we localised the chromosome X translocation breakpoint in a t(X;15) to be in the immediate proximity of the gene <i>ZDHHC15 </i>in a patient with severe mental retardation. Subsequent experiments revealed loss of <i>ZDHHC15</i> transcription in the patient which suggests this gene to be involved in the aetiology of the patient’s phenotype. In paper II, we show that a balanced translocation between chromosomes 6 and 17 in a patient with urogential malformation disrupts 2 genes, one at each translocation breakpoint. We also identified a fusion-gene as a result of the translocation. Our hypethesis is that the translocation together with its molecular consequences is important for the phenotype in the patient. Similarly, in paper III, we have used molecular characterisation of the breakpoints in a balanced translocation between chromosomes X and 11 in order to localise candidate genes in ovarian function. Our results indicate a number of genes affected by the translocation. In paper IV, we have used array-based comparative genomic hybridisation (array-CGH) in order to investigate a cohort of autistic sib-pairs for submicroscopic chromosomal alterations. We have identified several novel duplications and one novel deletion with strong association with autism.</p>

Chromosomal abnormalities are defined as changes in the chromosome structure and fall in one of two categories. The first category is numerical alterations while the second category consists of structural abnormalities. Structural chromosomal abnormalities do not always interrupt genes in order to cause disease. They can also affect gene expression by separating a gene and its promoter element from distant regulatory elements. We have used characterisation of structural chromosomal abnormalities to identify the genetic bases for several congenital disorders. In papers I-III, we have applied molecular characterisation of chromosomal translocations in order to identify candidate genes involved in mental retardation, hypospadias and anal malformation and premature ovarian failure. In paper I, we localised the chromosome X translocation breakpoint in a t(X;15) to be in the immediate proximity of the gene ZDHHC15 in a patient with severe mental retardation. Subsequent experiments revealed loss of ZDHHC15 transcription in the patient which suggests this gene to be involved in the aetiology of the patient’s phenotype. In paper II, we show that a balanced translocation between chromosomes 6 and 17 in a patient with urogential malformation disrupts 2 genes, one at each translocation breakpoint. We also identified a fusion-gene as a result of the translocation. Our hypethesis is that the translocation together with its molecular consequences is important for the phenotype in the patient. Similarly, in paper III, we have used molecular characterisation of the breakpoints in a balanced translocation between chromosomes X and 11 in order to localise candidate genes in ovarian function. Our results indicate a number of genes affected by the translocation. In paper IV, we have used array-based comparative genomic hybridisation (array-CGH) in order to investigate a cohort of autistic sib-pairs for submicroscopic chromosomal alterations. We have identified several novel duplications and one novel deletion with strong association with autism.

This thesis is a creative work of fiction in the form of one novella and four short stories. The collection is a work of humour and entertainment. “The Coin Collective” delves into the cut-throat world of cosplay, “The Dead of Waynesboro” follows Declan Mortel as her tries to create the ultimate zombie movie in true gothic fashion, “220 Torren Mill Road” is an epistolary horror story about a whack-job mother and her game-addicted son, “Dragon’s Lair Comics & Collectables” is set during a Magic the Gathering tournament and questions ‘what makes a monster?,’ and Chemical Connection explores drug and raver culture through an eclectic variety of characters. I hope the collection will speak to an entire generation of self-described and closet geeks. For those without intimate knowledge of the material, I endeavoured to exhibit, even expose, aspects of specific subcultures, shedding light on the basement dwellers who inhabit them.

Made available in DSpace on 2014-12-17T14:52:35Z (GMT). No. of bitstreams: 1 SaraDLP.pdf: 538708 bytes, checksum: ad7d4fbb39d43f6d22151b72748a78da (MD5) Previous issue date: 2008-10-27 / The objective of this dissertation is to propose a Multi Criteria Decision Aid Model to be used by the costumers of the travel agencies and help them to choose the best package travel. The main objective is to contribute for the simplification of the travel package decision choice from the identification of the models of values and preference of the customers and applying them to the existing package. It is used the Analytic Hierarchy Process (AHP) method to structuralize a decision hierarchic model composed by six criteria (package cost, hotel category, security of the city, travel time, direct flight and position in ranking of the 10 most visited destination) and five real alternatives of packages for a holiday of three days created from travel agency data. The decision analysis was realized for the choice of a travel package by a group composed by two couples that regularly travels together, to which was asked to do a pairwise judgment of the criteria and the alternatives. The mains results show that, although been a group that travels together, there are different models of values in the weights of the criteria and a certain convergence in the scales of preferences of the alternatives in the criteria. It was not pointed a dominant alternative for all the members of the group separately, but an analysis of a total utility of the group shows a classification and an order of the travel packages and an alternative clearly in front of the others. The sensitivity analysis revels that there are changes in the ranking, but the two alternatives best classified in the normal analysis are the same ones in the sensitivity analysis, although with the positions changed. The analysis also led to a simplification of the process with the exclusion of alternatives dominated for the others ones. As main conclusion, it is evaluated that the model and method suggested allow a simplification of the decision process in the choice of travel packages / O objetivo deste trabalho ? realizar uma modelagem de an?lise de decis?o multicriterial para apoio na decis?o para escolha de pacote de viagem por clientes das ag?ncias de turismos. O objetivo central ? contribuir na simplifica??o da decis?o da escolha de pacotes de viagens a partir da identifica??o dos modelos de valores e prefer?ncias dos clientes e aplic?-los em seguida aos pacotes existentes. ? utilizado o m?todo do Processo de Hierarquia Anal?tica (AHP Analytic Hierarchy Process) para estruturar um modelo hier?rquico de decis?o composto por seis crit?rios (custo do pacote, categoria do hotel, seguran?a da cidade, tempo de viagem, v?o direto, posi??o no ranking dos 10 mais destinos) e cinco alternativas reais de pacotes para fim de semana prolongado criadas a partir de dados de ag?ncia de viagens. A an?lise de decis?o foi realizada para a escolha do pacote por um grupo composto por dois casais que viajam regularmente juntos, aos quais foi solicitado que fizessem o julgamento par a par dos crit?rios e das alternativas. Os principais resultados revelam que, embora seja um grupo que viaja junto, h? diferentes modelos de valores nos pesos dos crit?rios e certa converg?ncia nas escalas de prefer?ncias das alternativas nos crit?rios. N?o houve uma alternativa dominante para todos os membros do grupo isoladamente, mas em uma an?lise de uma utilidade total do grupo h? uma classifica??o e ordenamento dos pacotes e uma alternativa claramente ? frente das demais. A an?lise de sensibilidade mostra que h? mudan?as nesse quadro, mas as duas mais bem classificadas na an?lise normal s?o as mesmas com a an?lise de sensibilidade, embora com mudan?a de posi??o. A an?lise levou tamb?m a simplificar o processo com a exclus?o de alternativas dominadas por todas as demais. Como principal conclus?o, avaliase que a modelagem e m?todo sugerido permitem uma simplifica??o do processo de decis?o na escolha de pacotes de viagens

INTRODUCTION: Anal cancer is increasing in the population, especially in HIV positive individuals. The group that currently has the highest incidence of anal cancer is HIV positive men who have sex with men. There are a number of treatment methods available to prevent pre-cancerous lesions called high grade squamous intraepithelial lesions (HSIL) from developing into cancer, however, these treatments are not currently routine. Randomized control trials are currently being conducted to assess the efficacy of these treatments in preventing anal cancer in high-risk populations. It is important to understand the motivations of individuals who are seeking to participate in anal cancer prevention studies. It is also important to learn about the experiences of participants who have enrolled in anal cancer prevention studies, and have in some situations undergone invasive procedures to treat their HSIL. METHODS: Participants in the AMC 076 study, an anal cancer prevention randomized control trial were recruited for the IMPACT 076 study. Two phone interviews were conducted and audio recordings were saved. Transcripts of the first set of interviews for 21 participants were analyzed and coded to gather qualitative data on the willingness of participants in the AMC 076 study to participate in a five-year anal cancer prevention study based on their experiences with pain and/or side effects in AMC 076. The research question about participation in the five-year study was hypothetical and not for the purpose of recruitment for the five-year study. RESULTS/DISCUSSION: We categorized participants into one of four groups: treatment group/treatment naïve, treatment group/treatment experienced, observation group/ treatment naive, and observation group/treatment experienced. When considering all participants who have received treatment at some point (either in the study or before the study), nine out of the thirteen would be willing to participate in the five-year study, three would not, and one was undecided. CONCLUSION: We concluded that previous pain or side effects did not appear to deter participants from participating in a five-year study. Based on the results of this study, the most common motivator for participation appeared to be altruism. The most common deterrent for participating in the five-year study was participants feeling that five years is too long to have their HSIL left untreated if they were to be randomized to the observation arm of the five-year study. Overall, participants were willing to deal with the pain and/or side effects of the exams and/or treatments in exchange for the feeling confident that their HSIL was removed or monitored and their risk of developing anal cancer is greatly reduced. / 2018-06-16T00:00:00Z

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2015-12-01T20:35:39Z No. of bitstreams: 1 SayonaraOliveiraFreitas_DISSERT.pdf: 2355112 bytes, checksum: c914329ad55998db1ef9d022f4f49ab9 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2015-12-08T23:03:12Z (GMT) No. of bitstreams: 1 SayonaraOliveiraFreitas_DISSERT.pdf: 2355112 bytes, checksum: c914329ad55998db1ef9d022f4f49ab9 (MD5) / Made available in DSpace on 2015-12-08T23:03:12Z (GMT). No. of bitstreams: 1 SayonaraOliveiraFreitas_DISSERT.pdf: 2355112 bytes, checksum: c914329ad55998db1ef9d022f4f49ab9 (MD5) Previous issue date: 2014-08-15 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / A ado??o estabelece o estado de filia??o, decorrente de ato jur?dico, atribuindo ? crian?a e aos pais os direitos e obriga??es inerentes a tal condi??o, sendo juridicamente irrevog?vel. Entretanto, na pr?tica, h? ado??es que n?o se concretizam, sendo a crian?a devolvida ? justi?a no decorrer ou mesmo ap?s o encerramento do processo judicial. Denomina-se ado??o tardia, a ado??o de crian?as com mais de dois anos, sendo esta ainda permeada por estigmas e mitos, sendo a devolu??o da crian?a ? justi?a mais frequente nestes casos. A ado??o tardia envolve um processo de constru??o de uma rela??o singular, com uma crian?a cuja hist?ria pregressa ? comumente marcada pelo rompimento da rela??o com a fam?lia de origem, por viola??o de direitos e, em alguns casos, pela experi?ncia do acolhimento institucional. Diante de tal cen?rio, esta pesquisa, fundamentado na Anal?tica Existencial proposta por Martin Heidegger, busca compreender a experi?ncia de m?es e filhos no processo de ado??o tardia, de modo a obter subs?dios ? aten??o psicol?gica neste contexto. Trata-se de um estudo qualitativo, fenomenol?gico, com enfoque compreensivo. Os participantes da pesquisa foram duas m?es e duas crian?as que concretizaram uma ado??o tardia h? mais de dois anos. Os procedimentos de constru??o dos dados contemplaram entrevistas narrativas com as m?es e encontros individuais com as crian?as, nos quais foram utilizados recursos l?dicos como mediadores de express?o (desenhos livres, hist?ria infantil inconclusa e ?Desenhos-Est?rias com Tema? sobre ado??o tardia). Os procedimentos foram audiogravados e transcritos. A an?lise dos dados foi feita a partir da hermen?utica heideggeriana. O processo de ado??o tardia, perpassado por determinantes hist?ricos, sociais e culturais e pela trama de significados que comp?e a hist?rica singular de cada um dos envolvidos revelou-se, a partir das narrativas, complexo. A constru??o dos sentidos de parentalidade e de filia??o vem se desenvolvendo, nas fam?lias do estudo, a partir da experi?ncia do ser-com o outro, do cuidado e do habitar, em seus peculiares modos de express?o. A fam?lia de origem e a fam?lia adotiva se confundem e se diferenciam na experi?ncia das crian?as, principalmente pela exist?ncia de irm?os biol?gicos. Os dados apontam para a import?ncia da aten??o psicol?gica ao n?cleo familiar em processos de ado??o tardia. / Adoption establishes a filiation status, resulting from a legal act, which attributes to the child and parents the rights and obligations associated with such condition, being legally irrevocable. Nevertheless, in practice there are adoptions that do not concretize and the child returns to justice during or even after the legal process is closed. Late adoption is the denomination of the adoption of children over two years and it is still permeated by myths and stigmas, leading to a frequent return of the child to justice in these cases. The late adoption involves a process of building a unique relationship with a child whose backstory is commonly marked by the dissolution of the relationship with the family of origin, due to violation of rights and, in some cases, the experience of institutional care. Given such a scenario, this research, based on the Existential Analytic proposed by Martin Heidegger, seeks to understand the experience of mothers and children in the process of late adoption, in order to obtain subsidies to psychological attention in this context. This is a qualitative, phenomenological study with a comprehensive focus. The participants were two mothers and two children who have gone through late adoption for about two years. The procedures of data generation contemplated narrative interviews with mothers and individual meetings with children, in which ludic resources were used as mediators of expression (free drawings, unfinished children's story and "Story-Drawings" on late adoption). The procedures were audiotaped and transcribed. Data analysis was grounded in Heidegger's hermeneutics. The late adoption process, permeated by historical, social and cultural determinants and the web of meanings that create the historical singularity of each person involved have proved to be complex as seen in the narratives. The construction of the meanings of parenthood and filiation has been developing in the families in the study, from the experience of being-with-the-other, caring and dwelling in their peculiar modes of expression. The family of origin and the adoptive family mingle and differentiate by means of the experience of children, especially because of the existence of biological siblings. Data point to the importance of psychological care to family core in late adoption processes