A circulação extracorpórea (CEC) substitui as funções do coração e pulmões durante o tempo principal da cirurgia cardíaca, permitindo que o cirurgião acesse o interior do órgão por longo período de tempo e assegurando a oxigenação dos tecidos e eliminação dos seus produtos finais. Entretanto, tal técnica não é utilizada rotineiramente em medicina veterinária devido aos elevados custos e também em decorrência das alterações deletérias que promove no organismo dos animais. Visando uma melhor compreensão das complicações decorrentes da CEC, possibilitando amenizá-las, aventou-se o estudo da conexina 43 (Cx43), proteína presente no miocárdio e responsável pela formação das junções intercelulares do tipo gap. O presente estudo avaliou cinco cães indenes, SRD, não submetidos à CEC, procedendo-se a colheita de amostras correspondentes à região do septo interventricular, átrios direito e esquerdo, ventrículos direito e esquerdo e posterior análise da Cx43 através da imunofluorescência, western blot e RT-PCR. Avaliou também cinco cães indenes, SRD, submetidos à toracotomia intercostal direita convencional e posterior instituição da CEC. Amostras de miocárdio foram colhidas em três distintos momentos, quais sejam: T0 (antes da CEC), T1 (após duas horas de CEC) e T2 (após uma hora de desmame da CEC), para verificar as possíveis alterações na (Cx43) decorrentes da CEC, pela técnica de imunofluorescência. Ao final do procedimento experimental, os animais foram sacrificados. Os resultados mostraram que nos animais indenes não operados, a Cx43 apresenta localização em todas as regiões estudadas, não apresentando diferença significativa com relação à expressão nas diferentes regiões. Porém, nos animais submetidos à CEC, a referida conexina apresentou-se diminuída. Por fim, concluímos que em cães a CEC por duas horas com uma hora de circulação espontânea é técnica exeqüível, porém determina sérias alterações clínicas e induz a processos patológicos. / Cardiopulmonary bypass (CPB) replaces the heart and lung function during the main period of cardiac surgery, and it allows the access of the surgeon inside the organ for a long time, ensuring tissue oxygenation and the elimination of end products. However, this procedure isn´t used as a routine in veterinary medicine because of the high costs, and besides it causes damage in the animal organism. In order to promote a better comprehension of the complications caused by CPB, and perhaps to assuage them, this work was designed to study the connexin 43 (Cx43), a protein present in myocardium which forms intercellular communications like gap junctions. To do so five health mongrel dogs not submitted to CPB were evaluated and tissue samples were taken from specific locals as ventricular septal, right and left atrium, right and left ventricle, to perform Cx43 analyses by immunofluorescence, western blot and RT-PCR. Were also studied others five health mongrel dogs submitted to a conventional right intercostal thoracotomy for CPB procedure. Samples of myocardium were taken in three different moments: T0 (before CPB), T1 (after two hours of CPB) and T2 (after one hour the end of CPB) to check possible alterations in Cx43 caused by CPB using immunofluorescence technique. The euthanasia of the animals was performed at the end of the experimental period. The results shown that in health animals not operated, the Cx43 is located in every studied local and there is no significant difference in the protein expression areas. Nevertheless, the CPB technique reduced the connexin expressions in the operated animals. Finally, we may conclude that the cardiopulmonary bypass for two hours and a spontaneous perfusion for one hour is a feasible procedure in dogs, but it determines serious clinical alterations and may induce pathophisyological process.

As conexinas são proteínas essenciais e estão diretamente relacionadas à propagação do impulso elétrico no coração, à velocidade de condução bem como à gênese de muitas afecções cardíacas. Em face da circulação extracorpórea (CEC) ainda ser utilizada de forma inconsistente na medicina veterinária e devido aos poucos estudos observados na literatura sobre os efeitos provocados pelo emprego da CEC na expressão da conexina 43 (Cx43) no miocárdio, objetivou-se avaliá-la em 15 animais da espécie canina, distribuidos em três grupos (C, CEC-1 e CEC -2) sendo, respectivamente, antes de realizada a CEC, com 60 minutos após esta e 60 minutos de CEC seguida de 30 minutos de restauração da perfusão espontânea. Avaliou-se a Cx43 pelas técnicas de imunofluorescência, western blot e RT-PCR em tempo real no tecido muscular cardíaco de regiões correspondentes aos átrios direito (AD) e esquerdo (AE), ventrículos direito (VD) e esquerdo (VE) e septo transverso. Os resultados indicaram a presença da Cx43 em todas as regiões do miocárdio nos grupos C, CEC-1 e CEC-2. A expressão da Cx43 variou significativamente em CEC-2 no AE e VD em relação ao grupo C (p<0,05). A expressão gênica de Gja1 (gene da Cx43) não apresentou diferença significativa entre os grupos estudados. Em CEC-2 identificou-se a presença de vacuolização na túnica média de artérias de pequeno calibre do miocárdio. Concluiu-se também que a canulação da aorta bem como a instalação do circuito de CEC no modo aorto-bicaval constitui técnica exequível / Connexins are essential proteins that are directly associated with electrical impulse propagation and speed of propagation in the heart. They also play a major role in numerous heart conditions. The use of cardiopulmonary bypass (CPB) in veterinary medicine is inconsistent and few studies describe the effect of cardiopulmonary bypass on the expression of connexin 43 (Cx43) in the myocardium. The objective of this study was to evaluate myocardial expression of Cx43. Connexin 43 of 15 dogs was assessed at 3 moments: prior to CPB (Group C); 60 minutes after CPB (Group CPB1); and 60 minutes after CPB followed by 30 minutes of spontaneous perfusion (Group CPB2). Assessment of Cx43 included immunofluorescence, western blot and RT-PCR real time of heart tissue samples from the right atrium (RA), left atrium (LA), right ventricle (LV), right ventricle (RV) and transverse septum. Our results showed the presence of Cx43 in all 5 areas of the myocardium in groups C, CPB1 and CPB2. A significant variation on the expression of Cx43 was observed when CPB2 LA and CPB2 RV were compared to group C (p<0,05). Expression of Gja1 (gene for Cx43) did not vary significantly among the study groups. Group CBP2 presented vacuolation of the tunica media of small myocardial arteries. We conclude that cannulation of the aorta and aorto-bicaval setup of the CPB circuit is feasible technique

Orientador: Maria José D'Elboux / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-23T02:20:00Z (GMT). No. of bitstreams: 1 Pergola-Marconato_AlineMaino_D.pdf: 6010690 bytes, checksum: 45ae36cd11e1369ccd7bd4efb047650e (MD5) Previous issue date: 2013 / Resumo: Introdução. A eficácia na aplicação dos primeiros socorros com a participação do leigo nas situações de emergência determina a sobrevivência das vítimas e aponta para a relevância de sua capacitação. Em âmbito nacional não existe programa modelo desta capacitação. Objetivos. Comparar o conhecimento dos alunos que participaram da capacitação em primeiros socorros do Curso de Formação de Condutores (CFC) com aqueles que participaram do curso elaborado e ministrado por profissional da saúde; adaptar, validar o conteúdo e testar a confiabilidade de questionário para avaliar conhecimentos de primeiros socorros de leigos; propor e aplicar programa para esta capacitação; identificar retenção do conteúdo dos participantes em ambos os cursos; e, comparar assimilação e retenção do conteúdo de ambos os grupos conforme a idade. Sujeitos e método. Estudo experimental em que se elaborou programa de capacitação teórica em primeiros socorros para leigos e o aplicou aos alunos do CFC divididos aleatoriamente em: Grupo Intervenção (GI) - participou do programa elaborado e Grupo Controle (GC) - do CFC. Mesmo questionário, composto por 29 questões fechadas, foi aplicado: Etapa I - antes, Etapa II - após e, Etapa III - três meses após participação na capacitação; adaptado e submetido à validação e teste de confiabilidade (estabilidade). Após a coleta, houve rearranjo conforme idade (GIA/GCA - idade inferior a 50 anos; GIB/GCB - superior ou igual a 50 anos). Atribuiu-se nota às respostas e o desempenho de cada indivíduo foi classificado: qualificado (7,1 a 10,0), pouco qualificado (5,0 a 7,0) e não qualificado (0 e 4,9). Resultados. Nove juízes (três leigos e seis especialistas) validaram o conteúdo e apenas 1/9 (11,2%) não considerou a parte do suporte básico de vida (SBV) abrangente devido à ausência de questão sobre reconhecimento da parada cardiorrespiratória. Dezesseis questões obtiveram concordância de 100,0% para clareza. No domínio Abordagem da vítima, 10/27 (37,0%) das questões apresentaram concordância perfeita (Kappa=1,0) e no SBV, 5/9 (55,6%) boa. Obteve se Coeficiente de Correlação Intraclasses indicativo de boa concordância para todo o instrumento (0,63). Amostra de 367 sujeitos (GI=182 e GC=185), homogênea quanto variáveis sociodemográficas entre grupos. Observou-se ascensão das notas médias da Etapa I (7,7) para a II (8,1) e, decréscimo na III (7,9) no GI. No GC também ocorreu esta oscilação, mas com notas menores (I - 5,3; II - 7,0; III - 6,3). No GI não houve nenhum classificado como não qualificado nas Etapas II e III. No GC, houve redução dos sujeitos não qualificados de 73/185 (39,5%) na I para 16/185 (8,6%) na II, mas na III ainda havia 25/185 (13,5%). Predominaram sujeitos qualificados no GIA. A comparação da classificação de desempenho entre grupos mostrou diferença significativa nas Etapas II e III (p<0,0001). Conclusão. Apesar de a capacitação ser apenas teórica, possibilitou aumento significativo de qualificados nas Etapas II e III do GI. A capacitação proposta propiciou assimilação e retenção adequada. Considerações finais. Sugere-se a aplicação deste programa, pois os resultados evidenciaram boa assimilação e retenção. Não houve amostra considerável de idosos, mas é essencial que recebam atenção especial na capacitação. Estudo inserido na Linha de Pesquisa Processo de Cuidar em Saúde e Enfermagem / Abstract: Background. The effective use of first aid with the lay people involvement in emergencies determines the survival of victims and points to the relevance of their training. Nationally there is no standard for this training program. Aims: Compare the knowledge of the students who participated in the Driver's License Course (DLC) first aid training with those who attended the course prepared and delivered by a health professional; adapt, validate the content and test the questionnaire reliability to assess knowledge of first aid laity; propose and apply this training program, identify retention of the content from the participants in both courses, and compare assessment and content retention from both groups according to age. Subjects and method. Experimental study where theoretical training program in first aid was developed and applied randomly for DLC lay students DLC, divided into Intervention Group (IG) - participated in the prepared program, and Group Control (GC) - CFC. A questionnaire consisting in 29 closed questions was applied: Stage I - before Stage II - after, and Stage III - three months after participation in the training, tailored and subject to validation and reliability testing (stability). Afterward, there was rearrangement with age (IGA / CGA - age under 50 years; IGB / CGB - greater than or equal to 50 years). A grade was assigned to responses, and performance of each individual was classified: Qualified (7.1 to 10.0), unskilled (5.0 to 7.0) and unskilled (0 and 4.9). Results. Nine judges (three nonprofessionals and six experts) validated the content, and only 1/9 (11.2%) did not consider part of the basic life support (BLS) due to the absence of comprehensive question in recognizing cardiopulmonary arrest. Sixteen questions had agreement of 100.0% for clarity. In the victim approach method, 10/27 (37.0%) of the questions were perfect agreement (Kappa = 1.0) and BLS, 5/9 (55.6%) good. It obtained intraclass correlation coefficient indicative of good agreement for the entire instrument (0.63). A sample of 367 subjects (IG = 182 and CG = 185), as homogeneous sociodemographic variables between groups. It was observed a rising of average marks of Stage I (7.7) for II (8.1) and decrease in III (7.9) in IG. CG also occurred in this oscillation, but with lower grades (I - 5.3 II - 7.0 III - 6.3). In IG there was no classified as unskilled in Stages II and III, and between skilled. In CG, a reduction of subjects unqualified 73/185 (39.5%) in the I to 16/185 (8.6%) in II, III but there was still 25/185 (13.5%). A comparison of the performance rating showed a significant difference between groups in Stages II and III (p <0.0001). Conclusion. Despite being just theoretical training, quality significantly increased in Stages II and III of the IG. The proposed training provided proper assimilation and retention. Final considerations. The implementation of this program is suggested, as the results pointed good uptake and retention. There was not a considerable sample of elderly, but it is essential that they receive special attention in training. This study was inserted on Line Research Process in Nursing and Health Care / Doutorado / Enfermagem e Trabalho / Doutora em Enfermagem

Introdução e Objetivos: A circulação extracorpórea (CEC) pode alterar a cinética de fármacos, inclusive dos antibióticos. O objetivo deste estudo foi avaliar influência da CEC sobre a farmacocinética da cefuroxima e verificar se o esquema posológico proposto: 1, 5g em bolus, seguido por três bolus de 750 mg 6/6 horas por 24 horas, mantém concentrações plasmáticas adequadas em pacientes submetidos à revascularização do miocárdio (RM). Método: Foi realizado estudo prospectivo observacional com grupo controle comparando 10 pacientes submetidos à RM com CEC e 9 pacientes submetidos à RM sem CEC (Registro Clincal trials: NCT0122882). Amostras sanguineas foram coletadas sequencialmente após cada dose de antibiótico e analisadas por meio do método de cromatografia líquida de alta pressão (HPLC). Análise de variância (ANOVA) foi utilizada para a comparação das concentrações plasmáticas e Log-rank para comparar as curvas que avaliaram o tempo, após a administração da cefuroxima, para que fossem atingidas concentrações abaixo de 16 g/mL (quatro vezes a MIC- mínima inhibitory concentration); considerando p< 0,05. Resultados: A CEC com tempo médio de 59,7 min 21,1 minutos não alterou a farmacocinética ou as concentrações plasmáticas da cefuroxima. O clearance médio dp (mL/ Kg/ min) e a mediana da concentração mínima (mg/ dL) do grupo RM com CEC versus RM sem CEC foram 1,7 0,7 versus 1,6 0,6 (p= 0,67) e 6,1 versus 5,7 (p= 0,77), respectivamente. Ambos os grupos apresentaram diminuição nas concentrações plasmáticas influenciadas somente pelo tempo, após cada bolus de cefuroxima (p< 0,001). Concentrações acima de quatro vezes a MIC foram mantidas por três horas, por todos os pacientes, porém, após seis horas do primeiro bolus a probabilidade de manutenção das mesmas concentrações foi de 0,2 para o grupo RM com CEC e de 0,44 para o grupo RM sem CEC, p= 0,867. Após os demais bolus concentrações abaixo de 16 g/mL foram atingidas antes de três horas. Conclusão: A CEC não influenciou as concentrações plasmáticas ou a farmacocinética da cefuroxima. Os resultados da farmacocinética devem ser considerados para a escolha de um melhor esquema posológico / Background and Objectives: Cardiopulmonary bypass (CPB) can alter the kinetic of drugs, including antibiotics. The aim of this study was evaluation of the CPB influence on the plasma concentrations and pharmacokinetics of cefuroxime and assess whether the dosing regimen 1.5 g dose, followed by 750 mg 6/6h for 24h is adequate for antibiotic prophylaxis. Methods: A prospective controlled observational study compared 10 patients undergoing surgery with CPB and 9 submitted to off-pump surgery, (Clinical trials identifier: NCT0122882). After each cefuroxime dose, blood samples were sequentially collected and analyzed using high-efficiency chromatography (HPLC). Plasma concentrations were compared using variance analysis and log-rank test was employed to evaluate the differences between curves that quantified the fraction of patients with a remaining plasma concentration above 16 mg/L within 6 h after each bolus; considering P < 0.05 significant. Results: After each cefuroxime bolus, both groups presented a significant decrease in plasma concentration over time (p< 0.001). Mean CPB time of 59.7 ± 21.1 min did not change cefuroxime pharmacokinetics or plasma concentrations. The mean clearance ± SD (mL/kg/min) and median of minimum concentration (mg/dL) of the CPB group versus the off-pump group were 1.7 ± 0.7 versus 1.6 ± 0.6 (p= 0.67) and 6.1 versus 5.7 (p= 0.77), respectively. Up to 3 h, but not after 6 h, following the first bolus, all patients had plasma concentrations above 16 mg/L (CPB group= 0.2 and off-pump group= 0.44, p=0.867). After another bolus, concentrations below 16 mg/dL were reached before 3 h. Conclusions: CPB does not influence cefuroxime plasma concentration, but pharmacokinetic data should be considered when choosing intervals between doses

The thesis deals with an overview of the history of First Aid, focusing on the development of cardiopulmonary resuscitation. It is a historical-comparative work of theoretical nature. The intention is to map the knowledge and experience that can be used effectively to develop and study the issue. When writing a thesis, an analysis of the available literature, both historical and contemporary, foreign and Czech, was used. Articles from professional periodicals and monographs were searched. The work was, for the sake of completeness, supplemented with period pictures and diagrams. The introduction justifies the choice of the topic and depicts the current state of knowledge in the field of First Aid. The next chapter explains the basic concepts which are important for orientation in the issue. Following a historical study First Aid aimed at developments providing cardiopulmonary resuscitation. The chapter is divided into subchapters describing the chronology of events to present recommendations for resuscitation and First Aid, so called CPR Guidelines 2015. The last chapter deals with the basic legal minimum. The outcome of this work is an extremely comprehensive overview of mapping the formation and development of First Aid from its history to current recommendations for resuscitation. This thesis...

Abstract Cardiac surgery with cardiopulmonary bypass induces the activation of systemic inflammatory response syndrome (SIRS) and results in at least some degree of global myocardial ischemia. Although these responses are usually short-lived, they may lead to serious complications and organ system failures. The present study evaluated the effects of high-dose glucose-insulin (1IU/kg/h) treatment (GIK) administered with the hyperinsulinemic normoglycemic clamp technique and a leukocyte-depleting filter on markers of systemic inflammatory response and myocardial ischemia-reperfusion injury in certain cardiac surgical risk groups. The study involved four prospective randomized controlled clinical trials and 119 patients. Cardioprotective effects were measured as myocardial enzyme release, recovery of contractile function and incidence of arrhythmias in all studies. The hemodynamic and metabolic effects of high-dose glucose-insulin treatment were evaluated in patients admitted for combined aortic valve (AS) and coronary surgery (40) and for urgent coronary surgery (39), and the latter study also involved proinflammatory cytokine and C-reactive protein analyses. The impacts of leukocyte filter on the expression of neutrophil adhesion molecules along with proinflammatory cytokines were evaluated in patients admitted for combined aortic valve (AS) and coronary surgery (20) and for solitary coronary surgery (20). The high-dose glucose-insulin treatment was associated with better preserved myocardial contractile function and less need for inotropic support after combined aortic valve and coronary surgery (I) and attenuation of postoperative CRP release after urgent coronary surgery (II). No effects on postoperative myocardial enzyme release (I, II) or on proinflammatory cytokine responses (II) were detected. The number of hypoglycemic events was low. The use of a leukocyte filter throughout the cardiopulmonary bypass period increased the neutrophil adhesion molecule CD11b expression in patients with both normal and prolonged CPB times and was associated with an enhanced proinflammatory cytokine response (III, IV). In conclusion, high-dose glucose-insulin treatment is safe, but requires strict control of blood glucose level. It reduces the need for inotropic support in patients with compromised cardiac status. The use of leukocyte filter leads to increased leukocyte activation and proinflammatory reaction.

Submitted in fulfillment of the requirements for the degree of Masters of Health Sciences in Clinical Technology, Durban University of Technology, Durban, South Africa, 2016. / Introduction: The immediate post-cardiopulmonary bypass (CPB) immune responses and organ injuries in immune- compromised patients remain poorly documented. We conducted a prospective clinical study to determine whether or not human immunodeficiency virus (HIV) seropositive patients generate higher acute systemic inflammatory response and suffer greater myocardial injury, compared to HIV seronegative patients. Methodology: Sixty-one consecutive patients i.e. Thirty HIV seropositive patients and Thirty-one seronegative, undergoing elective cardiac valve(s) replacement were enrolled, over a period of nine months from a single center hospital, after informed consent was acquired. The C-reactive protein (CRP) and Erythrocyte sedimentation rate (ESR) were used as biomarkers of acute inflammatory response, and cardiac troponin I (cTnI) as a biomarker for measuring postoperative myocardial injury. Single tests were measured preoperatively and postoperatively, in both groups, and these were compared and correlated to perioperative events and CPB parameters. Results: The mean age group was similar between the HIV seropositive and negative group (37.8 and 37.1 years, respectively). Preoperatively both groups had relatively equal CRP levels (p=0.388), ESR levels (p=0.817) and cTnI (p=0.489). The CPB events and durations were significantly different between the two groups, CPB duration (p=0.021). Other CPB events include, clamp aortic duration (p=0.026), CPB blood transfusion (p=0.013), CPB total urine output (p=0.035) and CPB peak lactate (p=0.040). Postoperatively we observed significant increased biomarkers level in both groups, with no significant difference between the groups: mean CRP (p=0.115), mean ESR (p=0.214) and cTnI (p=0.363). We observed a significant negative correlation between the mean change in CRP levels and mechanical ventilation (r=- 0.548, p=0.002) in the seropositive group, but not in the uninfected group (r=0.025, p=0.893). The correlation between the difference in CRP and ICU stay was not significant between in both group (r=-0.231, p=0.229 and r=0.25, p=0.975, respectively). A significant positive correlation between postoperative cTnI and the inotropic support duration (r=0.384, p=0.040) was seen in the seropositive groups, but not in the negative group (r=0.092, p=0.622). Furthermore we observed a significant drop in CD4 cells postoperatively (p=<0.001) in the HIV seropositive group. Antiretroviral treatment appeared to influence the degree of change in CD4 cells postoperatively. Conclusion: We conclude that HIV positive patients’ postoperative reactions to cardiac surgery supported by CPB are similar to those of HIV seronegetive patients. We further report non-paralleling correlations between the biomarkers and perioperative events; however these do not seem to affect the overall outcomes between the two groups. / M

Please read the abstract in the section 00front of this document / Thesis (PhD (Medical Immunology))--University of Pretoria, 2008. / Immunology / unrestricted

Severe congenital heart disease (CHD) is diagnosed in the United States 147.4 times per 100,000 live births, excluding still births and abortions^1. With the advancement of diagnostic methods, prenatal care, and screening modalities, the total CHD birth prevalence has increased substantially^2. In turn, this increases the number of cardiac surgery cases. With the advancement of technology and cardiac surgery, smaller and younger patients are undergoing more complex cardiac procedures that involve cardiopulmonary bypass (CPB). Neonates and infants undergoing CPB are susceptible to adverse effects of CPB on the coagulation cascade due to their smaller weight and hematologic immaturity^3,4. In addition to these physiological issues in neonates and infants, CPB decreases circulating coagulation factors and anti- thrombin III levels to 50% and platelet counts to 70%^5, which can contribute to the post-operative bleeding.During CPB, neonates' and infants' coagulation factors become extremely diluted causing multiple coagulation defects^6. Optimizing the CPB circuit volume and the use of anti-fibrinolytic, packed red blood cells (pRBCs), platelets, cryoprecipitate, and ultrafiltration are among the most widely used methods in preserving and aiding coagulation factors^3,7-9. Another method of improving hemodilution-related coagulation dysfunction bleeding is by transfusing Fresh Frozen Plasma (FFP)^10. However, there are only a small number of articles focusing on the effect of FFP in post-operative bleeding in neonates and infants following complex cardiac surgery with CPB. I postulate that adding FFP during CPB will lower the possibility of patients to experience post-operational bleeding, thus, shortening their length of stay (LOS).

Submitted by Nadir Basilio (nadirsb@uninove.br) on 2018-07-19T17:49:49Z No. of bitstreams: 1 Maria Helena Gomes de Sousa.pdf: 938639 bytes, checksum: 60ae02f298c21e9935dfa190fc6ea44b (MD5) / Made available in DSpace on 2018-07-19T17:49:49Z (GMT). No. of bitstreams: 1 Maria Helena Gomes de Sousa.pdf: 938639 bytes, checksum: 60ae02f298c21e9935dfa190fc6ea44b (MD5) Previous issue date: 2018-02-28 / Ergospirometric test, gold standard evaluation of cardiorespiratory fitness, is not an economically accessible and easy to apply test, especially for patients with Cerebral Vascular Accident (CVA) sequelae. Thus, field tests such as the Shuttle Walk Test Incremental (SWTI) may be another option for evaluation of cardiorespiratory function. Objective: compare the ventilatory, metabolic and cardiovascular responses obtained by the SWT and ergospirometric test, in hemiparetics due to stroke. Secondary objective was compared with the results of the ventilation evaluations with mild, moderate, marked and severe motor impairment of hemiparetic patients. Methodology: transversal study, with 20 hemiparetic subjects, motor impairment (05 mild, 04 moderate, 05 severe, 06 severe), 58 ± 10 years old, 08 women and 12 men. The VO2maximum (VO2), ventilatory (VE), desaturation, heart rate (HR) and blood pressure (BP), during the SWTI and ergospirometry, were evaluated in two days, 48h interval. Results: SpO2 was similar (97 [96-98]; 97 [94-97]) respectively in SWT and ergospirometry. VO2Pico metabolic variables (18 ± 4, 24 ± 4), cardiac FCPic (101 ± 17, 115 ± 15), systolic BP (140 [140-147], 160 [140-160]) and diastolic (2 ± 1, 3 ± 1), fatigue (2 [1-4], 4 [2-6]) and distance traveled (248 ± 154, 409 ± 1) 216). Comparison between groups of motor severity: ergospirometry showed variance in VO2peak and distance traveled between the light and severe group (p <0.05); others did not show significant differences. No SWTI, VO2Pico presented the difference between the moderate and striking groups (p <0.05) and the distance traveled between the light, striking and severe groups (p <0.05). Conclusion: SWTI is not similar to ergospirometry in the hemiparetic population due to stroke. Severe patients have poorer performance in both tests compared to the mild and moderate group, according to a Fugl-Meyer scale. / Teste ergoespirométrico, avaliação padrão ouro da aptidão cardiorrespiratória, não é um teste economicamente acessível e de fácil aplicabilidade, especialmente para pacientes com sequela de Acidente Vascular Cerebral (AVC). Assim, testes de campo como o Shuttle Walk Test Incremental(SWTI) podem ser outra opção de avaliação da função cardiorrespiratória. Objetivo: Comparar as respostas ventilatórias, metabólicas e cardiovasculares, obtidas pelo SWT e teste ergoespirométrico, em hemiparéticos decorrente de AVC. Objetivo secundário foi comparar os resultados das avaliações ventilatórias com o comprometimento motor leve, moderado, marcante e severo, dos pacientes hemiparéticos. Metodologia: estudo transversal, com 20 indivíduos hemiparéticos, comprometimento motor (05 leves, 04 moderados, 05 marcantes, 06 severos), 58±10 anos, 08 mulheres e 12 homens. Foram avaliados o consumo do VO2máximo(VO2), ventilação(VE), dessaturação, frequência cardíaca(FC) e pressão arterial(PA), durante o SWTI e ergoespirometria, realizados em dois dias, intervalo de 48h. Resultados: SpO2 foi semelhante (97[96-98]; 97[94-97]) respectivamente no SWT e ergoespirometria. Foram diferentes: as variáveis metabólicas VO2Pico (18±4; 24±4), cardíacas FCPico(101±17; 115±15), PA Sistólica(140[140-147]; 160[140-160]) e diastólica(85±6; 90±12), esforço percebido dispnéia (2±1; 3±1), fadiga(2[1-4]; 4[2-6]) e distância percorrida(248±154; 409±216). Comparação entre grupos de gravidade motora: ergoespirometria mostrou variância no VO2pico e distância percorrida entre o grupo leve e severo (p<0,05); demais não mostraram diferenças significativas. No SWTI, o VO2Pico apresentou diferença entre os grupos moderado e marcante(p<0,05) e na distância percorrida entre os grupos leve, marcante e severo(p<0,05). Conclusão: O SWTI não é similar à Ergoespirometria na população hemiparética decorrente de AVC. Os paciente severos tem menor desempenho em ambos os testes em comparação com o grupo leve e moderado, de acordo com a escala de Fugl-Meyer.