Global ETD Search

191	Návrh synchronního reluktančního motoru s permanentními magnety / Design of synchronous reluctance motor with permanent magnets Knebl, Ladislav January 2017 (has links) V dnešní době je kladen vysoký nárok na účinnost elektrických zařízení a to jak ze strany provozovatele, tak i legislativy. Nejlepší účinnosti dosahují synchronní motory s permanentními magnety umístěnými na povrchu rotoru (SMPM), se kterými lze i u malých motorů dosáhnout účinnosti nad 90%. Nicméně tyto motory jsou z důvodů použití magnetů ze vzácných zemin, např. NdFeB, drahé a jsou schopny provozu pouze s frekvenčním měničem. Z cenových důvodů jsou hledány levnější alternativy k SMPM motorům. Jedním z typů motorů, kterým lze SMPM nahradit je synchronní reluktanční motor s permanentními magnety (PMASR). Tento motor je cenově výhodnější, protože používá menší množství magnetů, při zachování podobných, mnohdy i lepších vlastností, nicméně neodpadá potřeba použití frekvenčního měniče. Navíc je zde možnost použití levnějších feritových magnetů a tím ještě výrazněji snížit cenu motoru. V této práci bude PMASR topologie popsána důkladněji včetně elektromagnetického návrhu metodou konečných prvků. Bude provedena i mechanická analýza zvoleného optimálního modelu. Výsledky dosažené metodou konečných prvků budou následně porovnány s analytickým modelem. Z navrženého modelu bude vyroben prototyp a naměřené výsledky budou porovnány s výpočty.
192	Processos erosivos lineares nas bacias dos Rios Claro e dos Bois, afluentes do Rio Araguaia no Estado de Goiás: relações com a cobertura vegetal e uso da terra / Linear erosion processes in the basins of the rivers course and Bois, tributaries of the Rio Araguaia in Goiás State: relationships with vegetation cover and land use BARBALHO, Maria Gonçalves da Silva 19 August 2010 (has links) Made available in DSpace on 2014-07-29T12:05:36Z (GMT). No. of bitstreams: 1 Maria Goncalves da Silva.pdf: 7545290 bytes, checksum: d2d0b32033e574f5829cacf879cb1d63 (MD5) Previous issue date: 2010-08-19 / The pattern of land use and occupation of the Cerrado associated with the expansion of the agricultural frontier, in the last 40 years, has been interpreted as causing environmental impacts observed him during this period, especially those related to intensive deforestation and indiscriminate use of areas with soils with low or null agricultural capability, although capable of extensive pastures. The Erosion processes have been described as the most significant, positioned after the remarkable loss of biodiversity, the most important and extensive in area. The present thesis analyzes the relationship between the land use valued at historical series started in the decade of 1975, agricultural suitability of land use pattern and the erosion and silting sites of the two combined basins for purposes of this study, called basins of the rivers Claro and Bois, tributaries of the upper Araguaia river in the state of Goiás. This area was considered in previous studies as the most affected by deforestation among the five sub-basins that make up the upper Araguaia river basin. The research was based an integrated analysis of the physical environment and biota components of the focus area, with base on remote sensing and GIS and pedotransfer criteria. The results are presented as scientific papers and reveal that the most intensive phase of deforestation occurred in the 1980s, when the Forest Formations were most penalized originally, followed by the Savanna Formations, that the conversion occurred in favor of extensive pastures, for which the area has good suitability soil and relief associates; that the numerous of linear erosion impacts, 395 linear erosion features placed in degraded pastures are concentrated in these areas, which predominate low discrepancies between suitability and actual use. As evidenced in the spatial analysis, it is confirmed the presence of 395 linear erosion features associated with degraded pastures. It is concluded that the area supports the pattern of initial occupation of the Cerrado by its conversion to pasture and that environmental impacts arising from the management of them more than this type of use. / O padrão de uso e ocupação das terras do Cerrado associado à expansão de fronteira agrícola, nos últimos 40 anos, tem sido interpretado como o causador dos impactos ambientais nele constatados nesse período, sobretudo os relativos ao desmatamento intensivo e indiscriminado de áreas com solos com baixa ou nula aptidão agrícola, ainda que aptos a pastagem extensiva. Os processos erosivos têm sido apontados como os mais significativos, posicionados após a perda notável da biodiversidade, o mais importante e extenso em área. A presente tese analisa a relação entre o uso do solo avaliado em série histórica iniciada na década de 1975, a aptidão agrícola das terras e os focos erosivos e de assoreamento das duas bacias conjugadas para fins deste trabalho, denominadas bacias dos rios Claro e dos Bois, afluentes do alto rio Araguaia, no Estado de Goiás. Essa área foi considerada em trabalhos anteriores como a mais afetada pelos desmatamentos dentre as cinco principais sub-bacias que compõem a alta bacia do rio Araguaia. A pesquisa baseou-se na análise integrada dos componentes do meio físico e biótico da área focada, com base em sensoriamento remoto e geoprocessamento e em pedotransferência. Os resultados são apresentados na forma de artigos científicos e revelam que a fase mais intensiva do desmatamento deu-se na década de 1980, que as Formações Florestais foram inicialmente as mais penalizadas, seguindo-se as Formações Savânicas; que a conversão deu-se em favor das pastagens extensivas, para o que a área apresenta boa aptidão dos solos e relevo associados; que os numerosos impactos erosivos lineares concentram-se nessas áreas, ainda que seja onde predominam discrepâncias baixas entre aptidão e o uso atual. Como evidenciado na análise espacial, constatou-se a presença de 395 focos erosivos lineares associados às áreas de pastagens degradadas. Conclui-se que a área corrobora o padrão de ocupação inicial do Cerrado por sua conversão em pastagem e que os impactos ambientais derivam mais do manejo das mesmas do que desse tipo de uso. alta bacia do rio Araguaia rios Claro e dos Bois uso do solo pastagens degradadas impactos ambientais erosivos sensoriamento remoto geoprocessamento upper Araguaia river basin rivers Claro and Bois land use degraded pastures environmental impacts of erosion remote sensing GIS CNPQ::OUTROS::CIENCIAS
193	Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products McCanna, David January 2009 (has links) The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty associated with dose selection for clinical trials. The first section of this thesis describes how in vitro methods can be used to improve the prediction of the toxicity of chemicals and ophthalmic products. The proper utilization of in vitro methods can accurately predict toxic threshold levels and reduce animal use in product development. Sections two, three and four describe the development of new sensitive in vitro methods for predicting ocular toxicity. Maintaining the barrier function of the cornea is critical for the prevention of the penetration of infections microorganisms and irritating chemicals into the eye. Chapter 2 describes the development of a method for assessing the effects of chemicals on tight junctions using a human corneal epithelial and canine kidney epithelial cell line. In Chapter 3 a method that uses a primary organ culture for assessing single instillation and multiple instillation toxic effects is described. The ScanTox system was shown to be an ideal system to monitor the toxic effects over time as multiple readings can be taken of treated bovine lenses using the nondestructive method of assessing for the lens optical quality. Confirmations of toxic effects were made with the utilization of the viability dye alamarBlue. Chapter 4 describes the development of sensitive in vitro assays for detecting ocular toxicity by measuring the effects of chemicals on the mitochondrial integrity of bovine cornea, bovine lens epithelium and corneal epithelial cells, using fluorescent dyes. The goal of this research was to develop an in vitro test battery that can be used to accurately predict the ocular toxicity of new chemicals and ophthalmic formulations. By comparing the toxicity seen in vivo animals and humans with the toxicity response in these new in vitro methods, it was demonstrated that these in vitro methods can be utilized in a tiered testing strategy in the development of new chemicals and ophthalmic formulations. in vitro Alternative Methods alamarBlue rhodamine tight junctions bovine lens viability toxicity mitochondria mitochondria integrity benzalkonium chloride sodium dodecyl sulphate sodium lauryl sulfate scanning electron microscopy Draize Draize maximal average scores zonula occludens cosmetic directive PETA humane society animal league ICCVAM ECVAM JaCVAM BCOP bovine cornea ocular irritants ocular irritation ocular toxicity human corneal epithelial cells vitro confocal confocal microscopy metabolic activity optical quality reactive oxygen species contact lens contact lens care solutions barrier function microbial keratitis mulitipurpose solutions tight junction cell damage claudin ZO-1 occludin MDCK Madin Madin-Darby canine kidney cells cornea human cornea human corneal epithelium epithelial cell line human corneal epithelial cell line sodium fluorescein sodium fluorescein permeability fluorescein permeability ocular surface cell monolayer Araki-Sasaki cell physiology risk assessment safety assessment ScanTox scanning laser lens epithelium corneal cells in vitro model ophthalmic formulations multiple instillation back vertex animal testing rabbit testing alternatives to animal testing cultured bovine lens toxicity of chemicals irritation irritants laser scanner organ culture delayed toxicity toxins hydrogen peroxide cornea toxicity cornea toxicity models prediction of human toxicity no observable adverse effect level lowest observable adverse effect level NOAEL LOAEL toxicity thresholds safety factors cornea uncertainty factors preservatives disinfectants ophthalmic products preclinical preclinical testing epithelial barrier drug penetration clinical confocal microscopy animal rights rabbit cornea human cornea human clinical effects toxic animal rights activist sensitive measures toxic effect toxicity threshold agar overlay agar diffusion agar overlay method agar diffusion method cytochrome cytochrome c apoptosis necrotic apoptotic necrosis caspase rhodamine 123 resazuran resorufin cell death cell viability metabolic dye microsomal microsomal enzymes cytotoxicity cytotoxic cytotoxic effect MTT XTT WST-1 plasma membrane mitochondrial mitochondrial morphology ocular toxicity potential ocular toxicity human corneal epithelial cell line confocal analysis corneal epithelium cell fluorescence alamarBlue assay rhodamine dye animal welfare toxic injury degraded mitochondria epithelial monolayer disinfectants membrane integrity eye toxicity eye viability dye toxicity in humans human toxicity effects on the mitochondria mitochondrial toxicity in vitro battery in vitro test battery ophthalmic eye drop direct contact product safety cytotoxicity potential molecular molecular biology refine reduce replace sensitivity and relevance sensitivity relevance rabbit ocular irritation test product development cytotoxicity models cytotoxicity alternative methods replacements for animal testing three r's beagle tiered testing tiered testing strategy replacements animal testing mechanistic toxicity cornea mitochondria dose response threshold Vision Science and Biology
194	Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products McCanna, David January 2009 (has links) The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty associated with dose selection for clinical trials. The first section of this thesis describes how in vitro methods can be used to improve the prediction of the toxicity of chemicals and ophthalmic products. The proper utilization of in vitro methods can accurately predict toxic threshold levels and reduce animal use in product development. Sections two, three and four describe the development of new sensitive in vitro methods for predicting ocular toxicity. Maintaining the barrier function of the cornea is critical for the prevention of the penetration of infections microorganisms and irritating chemicals into the eye. Chapter 2 describes the development of a method for assessing the effects of chemicals on tight junctions using a human corneal epithelial and canine kidney epithelial cell line. In Chapter 3 a method that uses a primary organ culture for assessing single instillation and multiple instillation toxic effects is described. The ScanTox system was shown to be an ideal system to monitor the toxic effects over time as multiple readings can be taken of treated bovine lenses using the nondestructive method of assessing for the lens optical quality. Confirmations of toxic effects were made with the utilization of the viability dye alamarBlue. Chapter 4 describes the development of sensitive in vitro assays for detecting ocular toxicity by measuring the effects of chemicals on the mitochondrial integrity of bovine cornea, bovine lens epithelium and corneal epithelial cells, using fluorescent dyes. The goal of this research was to develop an in vitro test battery that can be used to accurately predict the ocular toxicity of new chemicals and ophthalmic formulations. By comparing the toxicity seen in vivo animals and humans with the toxicity response in these new in vitro methods, it was demonstrated that these in vitro methods can be utilized in a tiered testing strategy in the development of new chemicals and ophthalmic formulations. in vitro Alternative Methods alamarBlue rhodamine tight junctions bovine lens viability toxicity mitochondria mitochondria integrity benzalkonium chloride sodium dodecyl sulphate sodium lauryl sulfate scanning electron microscopy Draize Draize maximal average scores zonula occludens cosmetic directive PETA humane society animal league ICCVAM ECVAM JaCVAM BCOP bovine cornea ocular irritants ocular irritation ocular toxicity human corneal epithelial cells vitro confocal confocal microscopy metabolic activity optical quality reactive oxygen species contact lens contact lens care solutions barrier function microbial keratitis mulitipurpose solutions tight junction cell damage claudin ZO-1 occludin MDCK Madin Madin-Darby canine kidney cells cornea human cornea human corneal epithelium epithelial cell line human corneal epithelial cell line sodium fluorescein sodium fluorescein permeability fluorescein permeability ocular surface cell monolayer Araki-Sasaki cell physiology risk assessment safety assessment ScanTox scanning laser lens epithelium corneal cells in vitro model ophthalmic formulations multiple instillation back vertex animal testing rabbit testing alternatives to animal testing cultured bovine lens toxicity of chemicals irritation irritants laser scanner organ culture delayed toxicity toxins hydrogen peroxide cornea toxicity cornea toxicity models prediction of human toxicity no observable adverse effect level lowest observable adverse effect level NOAEL LOAEL toxicity thresholds safety factors cornea uncertainty factors preservatives disinfectants ophthalmic products preclinical preclinical testing epithelial barrier drug penetration clinical confocal microscopy animal rights rabbit cornea human cornea human clinical effects toxic animal rights activist sensitive measures toxic effect toxicity threshold agar overlay agar diffusion agar overlay method agar diffusion method cytochrome cytochrome c apoptosis necrotic apoptotic necrosis caspase rhodamine 123 resazuran resorufin cell death cell viability metabolic dye microsomal microsomal enzymes cytotoxicity cytotoxic cytotoxic effect MTT XTT WST-1 plasma membrane mitochondrial mitochondrial morphology ocular toxicity potential ocular toxicity human corneal epithelial cell line confocal analysis corneal epithelium cell fluorescence alamarBlue assay rhodamine dye animal welfare toxic injury degraded mitochondria epithelial monolayer disinfectants membrane integrity eye toxicity eye viability dye toxicity in humans human toxicity effects on the mitochondria mitochondrial toxicity in vitro battery in vitro test battery ophthalmic eye drop direct contact product safety cytotoxicity potential molecular molecular biology refine reduce replace sensitivity and relevance sensitivity relevance rabbit ocular irritation test product development cytotoxicity models cytotoxicity alternative methods replacements for animal testing three r's beagle tiered testing tiered testing strategy replacements animal testing mechanistic toxicity cornea mitochondria dose response threshold Vision Science and Biology

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