Global ETD Search

1	An essay on suspended animation Jackson, Samuel, January 1808 (has links) Thesis (M.D.)--University of Pennsylvania, 1808. / Microform version available in the Readex Early American Imprints series.
2	Encouraging Development of Mobile Applications as a Service to the Community Forney, Vanessa Marie 01 November 2016 (has links) The convenience of mobile applications combined with the efficiency and effectiveness provided by technology has contributed to an increased interest in mobile applications. Local groups and non-profit organizations often utilize outdated, manual processes and don’t have the resources or time to look into improving these systems. For Cal Poly students and other members of the community, this means there is an opportunity to apply technical skills and school projects to address these inefficiencies. This work explores whether a better system can be developed to provide the functionality of the existing system and enhance the experience of users through technology, data tracking, and automation. Two apps demonstrate the application of technology to meet needs within the San Luis Obispo community: Poly Rides is an iOS and Android application that improves ridesharing for Cal Poly students. The idea stemmed from the Cal Poly Rideshare Facebook page, where the posting format for a ride is inconsistent, making it difficult to find a ride match. The Poly Rides app provides an improved user interface for posting, searching, and coordinating rides with other students. Its success has been validated through the popularity of the app. There were 3734 installations and 7925 messages sent as of May 27, 2016. Woods is an iOS application for iPhone, iPad, and Apple Watch that improves the care tracking process for dogs at Woods Humane Society. The previous technique involved updating a whiteboard to manage the information and care for the avail- able dogs. The whiteboard had inconsistent and limited information, was often out of date, and did not have room to list all of the dogs. An app was created which automatically pulls the dogs from the shelter database, provides more detailed information and instructions, and is available for volunteers on their personal devices. The results revealed a much larger and more positive impact than originally anticipated; volunteers reported feeling more confident providing appropriate care to the dog (65.9%) and that they have more trust in the dogs’ information (52.3%). Of staff and volunteers, 83.9% prefer the app over the whiteboard and 10.7% have no preference. Dog breed, size, age, and photo, details not available on the whiteboard, were reported to be “Very” or “Extremely” important by 56.8% of volunteers. This thesis describes some important requirements for developing community service mobile applications, offers suggestions for facilitating the development of a high quality product, and lists some useful resources for iOS development. Both apps not only reach their goal of improving a manual process in the local community, but also have the potential to improve and impact other communities around the world. mobile applications woods humane society poly rides ios development Other Computer Engineering
3	The rhetorical dimensions of radical flank effects investigations into the influence of emerging radical voices on the rhetoric of long-standing moderate organizations in two social movements / Dillard, Courtney Lanston. January 2002 (has links) (PDF) Thesis (Ph. D.)--University of Texas at Austin, 2002. / Vita. Includes bibliographical references. Available also from UMI Company.
4	The rhetorical dimensions of radical flank effects: investigations into the influence of emerging radical voices on the rhetoric of long-standing moderate organizations in two social movements Dillard, Courtney Lanston 28 August 2008 (has links) Not available / text Social movements Radicalism Humane Society of the United States Sierra Club Earth First! (Organization)
5	A garantia do direito ao meio ambiente saudável pela (re)construção da racionalidade ética social contemporânea fundada na alteridade Giongo, Rafaela Luiza Pontalti 14 January 2010 (has links) Submitted by CARLA MARIA GOULART DE MORAES (carlagm) on 2015-04-09T17:14:15Z No. of bitstreams: 1 RafaelaGiongoDireito.pdf: 1393721 bytes, checksum: e3c98423d409555d74661ce93c754798 (MD5) / Made available in DSpace on 2015-04-09T17:14:15Z (GMT). No. of bitstreams: 1 RafaelaGiongoDireito.pdf: 1393721 bytes, checksum: e3c98423d409555d74661ce93c754798 (MD5) Previous issue date: 2010-01-14 / Nenhuma / A presente dissertação vincula-se à linha de pesquisa Sociedade, Novos Direitos e Transnacionalização do Programa de Pós-Graduação em Direito da Universidade do Vale do Rio dos Sinos ? UNISINOS, apresentando a temática da garantia do meio ambiente saudável, como um direito fundamental, através da (re)construção da racionalidade ética social contemporânea, fundada na categoria da alteridade. Como objetivos específicos procurou-se caracterizar a sociedade contemporânea como sociedade de risco e a promoção dos direitos fundamentais nesse contexto; e identificar a possibilidade de garantia do meio ambiente saudável como um direito fundamental, através da (re)construção da racionalidade ética social na categoria da alteridade, permitindo uma sociedade humana e ecologicamente viável. A pesquisa estruturou-se através do método de abordagem hipotético-dedutivo, desenvolvendose a partir de dois aportes teóricos distintos que serviram a propósitos diferenciados: Teoria dos Sistemas Sociais, desenvolvida por Niklas Luhmann, para observar a sociedade contemporânea e ilustrá-la como produtora de riscos, e o meio ambiente saudável como direito fundamental nesse contexto; e Ética da Alteridade, criada por Emmanuel Levinas, para a proposta de (re)construção da racionalidade ética social contemporânea como fundamento de uma sociedade humana e ecologicamente viável e hipótese conciliadora ao problema apresentado. Aplicou-se a categoria da alteridade ao meio ambiente, uma vez que se pode interpretá-lo como débil (ou frágil) em relação ao homem. A presente interpretação torna-se cabível em decorrência das decisões humanas, que representam um espaço intersubjetivo assimétrico para com o meio ambiente, em razão da produção e distribuição de novas espécies de riscos, os quais, sem precedentes históricos, possibilitam a destruição de toda a vida no planeta. Pôde-se concluir que ao se considerar o meio ambiente degradado como sendo o Outro, somos chamados a dar uma ?resposta? ao atual questionamento inserido pela crise ambiental, possibilitando à sociedade a abertura de uma relação de responsabilidade, ou seja, a uma relação ética e equilibrada com o meio ambiental. / This work is linked to the research line Society, New Rights and Transnationalization of the Graduate Program in Law, of the University of Vale do Rio dos Sinos - UNISINOS,featuring the theme of ensuring a healthy environment as a fundamental right, through the (re) construction of contemporary social ethical rationality, founded on the category of otherness. As specific objectives tried to characterize contemporary society as risk society and the promotion of fundamental rights in this context; and identify the possibility of ensuring a healthy environment as a fundamental right, through the (re) construction of rationality in the category of social ethics otherness, allowing a human society and ecologically viable. The research was structured by the method of hypothetical-deductive approach, developing from two distinct theoretical contributions that have served for different purposes: Theory of Social Systems, developed by Niklas Luhmann, to observe the contemporary society and illustrate it as producer risk, and healthy environment as a fundamental right in this contex; and Ethics of Alterity, created by Emmanuel Levinas, for the proposed (re) construction of rationality contemporary social ethics as the foundation of human society and ecologically viable and conciliatory to the hypothesis problem presented. The category of otherness to the environment was applied, since it may interpret it as weak (or fragile) in relation to man. This interpretation becomes appropriate as a result of human decisions, which represent an intersubjective space asymmetrical with the environment, due to the production and distribution of new kinds of risks, which, without historical precedent, allow for the destruction of all life on the planet. It was concluded that when considering the degraded environment as the Other, we are called to give an answer to the current environmental crisis by questioning inserted, enabling the society to open a relationship of responsibility, in other words, a relationship ethics and balanced with the surrounding environment. Sociedade de risco Direitos fundamentais Meio ambiente saudável Racionalidade ética Alteridade Risk society Fundamental rights Healthy environment Ethical rationality Otherness Humane society and ecologically viable
6	Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products McCanna, David January 2009 (has links) The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty associated with dose selection for clinical trials. The first section of this thesis describes how in vitro methods can be used to improve the prediction of the toxicity of chemicals and ophthalmic products. The proper utilization of in vitro methods can accurately predict toxic threshold levels and reduce animal use in product development. Sections two, three and four describe the development of new sensitive in vitro methods for predicting ocular toxicity. Maintaining the barrier function of the cornea is critical for the prevention of the penetration of infections microorganisms and irritating chemicals into the eye. Chapter 2 describes the development of a method for assessing the effects of chemicals on tight junctions using a human corneal epithelial and canine kidney epithelial cell line. In Chapter 3 a method that uses a primary organ culture for assessing single instillation and multiple instillation toxic effects is described. The ScanTox system was shown to be an ideal system to monitor the toxic effects over time as multiple readings can be taken of treated bovine lenses using the nondestructive method of assessing for the lens optical quality. Confirmations of toxic effects were made with the utilization of the viability dye alamarBlue. Chapter 4 describes the development of sensitive in vitro assays for detecting ocular toxicity by measuring the effects of chemicals on the mitochondrial integrity of bovine cornea, bovine lens epithelium and corneal epithelial cells, using fluorescent dyes. The goal of this research was to develop an in vitro test battery that can be used to accurately predict the ocular toxicity of new chemicals and ophthalmic formulations. By comparing the toxicity seen in vivo animals and humans with the toxicity response in these new in vitro methods, it was demonstrated that these in vitro methods can be utilized in a tiered testing strategy in the development of new chemicals and ophthalmic formulations. in vitro Alternative Methods alamarBlue rhodamine tight junctions bovine lens viability toxicity mitochondria mitochondria integrity benzalkonium chloride sodium dodecyl sulphate sodium lauryl sulfate scanning electron microscopy Draize Draize maximal average scores zonula occludens cosmetic directive PETA humane society animal league ICCVAM ECVAM JaCVAM BCOP bovine cornea ocular irritants ocular irritation ocular toxicity human corneal epithelial cells vitro confocal confocal microscopy metabolic activity optical quality reactive oxygen species contact lens contact lens care solutions barrier function microbial keratitis mulitipurpose solutions tight junction cell damage claudin ZO-1 occludin MDCK Madin Madin-Darby canine kidney cells cornea human cornea human corneal epithelium epithelial cell line human corneal epithelial cell line sodium fluorescein sodium fluorescein permeability fluorescein permeability ocular surface cell monolayer Araki-Sasaki cell physiology risk assessment safety assessment ScanTox scanning laser lens epithelium corneal cells in vitro model ophthalmic formulations multiple instillation back vertex animal testing rabbit testing alternatives to animal testing cultured bovine lens toxicity of chemicals irritation irritants laser scanner organ culture delayed toxicity toxins hydrogen peroxide cornea toxicity cornea toxicity models prediction of human toxicity no observable adverse effect level lowest observable adverse effect level NOAEL LOAEL toxicity thresholds safety factors cornea uncertainty factors preservatives disinfectants ophthalmic products preclinical preclinical testing epithelial barrier drug penetration clinical confocal microscopy animal rights rabbit cornea human cornea human clinical effects toxic animal rights activist sensitive measures toxic effect toxicity threshold agar overlay agar diffusion agar overlay method agar diffusion method cytochrome cytochrome c apoptosis necrotic apoptotic necrosis caspase rhodamine 123 resazuran resorufin cell death cell viability metabolic dye microsomal microsomal enzymes cytotoxicity cytotoxic cytotoxic effect MTT XTT WST-1 plasma membrane mitochondrial mitochondrial morphology ocular toxicity potential ocular toxicity human corneal epithelial cell line confocal analysis corneal epithelium cell fluorescence alamarBlue assay rhodamine dye animal welfare toxic injury degraded mitochondria epithelial monolayer disinfectants membrane integrity eye toxicity eye viability dye toxicity in humans human toxicity effects on the mitochondria mitochondrial toxicity in vitro battery in vitro test battery ophthalmic eye drop direct contact product safety cytotoxicity potential molecular molecular biology refine reduce replace sensitivity and relevance sensitivity relevance rabbit ocular irritation test product development cytotoxicity models cytotoxicity alternative methods replacements for animal testing three r's beagle tiered testing tiered testing strategy replacements animal testing mechanistic toxicity cornea mitochondria dose response threshold Vision Science and Biology
7	Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products McCanna, David January 2009 (has links) The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty associated with dose selection for clinical trials. The first section of this thesis describes how in vitro methods can be used to improve the prediction of the toxicity of chemicals and ophthalmic products. The proper utilization of in vitro methods can accurately predict toxic threshold levels and reduce animal use in product development. Sections two, three and four describe the development of new sensitive in vitro methods for predicting ocular toxicity. Maintaining the barrier function of the cornea is critical for the prevention of the penetration of infections microorganisms and irritating chemicals into the eye. Chapter 2 describes the development of a method for assessing the effects of chemicals on tight junctions using a human corneal epithelial and canine kidney epithelial cell line. In Chapter 3 a method that uses a primary organ culture for assessing single instillation and multiple instillation toxic effects is described. The ScanTox system was shown to be an ideal system to monitor the toxic effects over time as multiple readings can be taken of treated bovine lenses using the nondestructive method of assessing for the lens optical quality. Confirmations of toxic effects were made with the utilization of the viability dye alamarBlue. Chapter 4 describes the development of sensitive in vitro assays for detecting ocular toxicity by measuring the effects of chemicals on the mitochondrial integrity of bovine cornea, bovine lens epithelium and corneal epithelial cells, using fluorescent dyes. The goal of this research was to develop an in vitro test battery that can be used to accurately predict the ocular toxicity of new chemicals and ophthalmic formulations. By comparing the toxicity seen in vivo animals and humans with the toxicity response in these new in vitro methods, it was demonstrated that these in vitro methods can be utilized in a tiered testing strategy in the development of new chemicals and ophthalmic formulations. in vitro Alternative Methods alamarBlue rhodamine tight junctions bovine lens viability toxicity mitochondria mitochondria integrity benzalkonium chloride sodium dodecyl sulphate sodium lauryl sulfate scanning electron microscopy Draize Draize maximal average scores zonula occludens cosmetic directive PETA humane society animal league ICCVAM ECVAM JaCVAM BCOP bovine cornea ocular irritants ocular irritation ocular toxicity human corneal epithelial cells vitro confocal confocal microscopy metabolic activity optical quality reactive oxygen species contact lens contact lens care solutions barrier function microbial keratitis mulitipurpose solutions tight junction cell damage claudin ZO-1 occludin MDCK Madin Madin-Darby canine kidney cells cornea human cornea human corneal epithelium epithelial cell line human corneal epithelial cell line sodium fluorescein sodium fluorescein permeability fluorescein permeability ocular surface cell monolayer Araki-Sasaki cell physiology risk assessment safety assessment ScanTox scanning laser lens epithelium corneal cells in vitro model ophthalmic formulations multiple instillation back vertex animal testing rabbit testing alternatives to animal testing cultured bovine lens toxicity of chemicals irritation irritants laser scanner organ culture delayed toxicity toxins hydrogen peroxide cornea toxicity cornea toxicity models prediction of human toxicity no observable adverse effect level lowest observable adverse effect level NOAEL LOAEL toxicity thresholds safety factors cornea uncertainty factors preservatives disinfectants ophthalmic products preclinical preclinical testing epithelial barrier drug penetration clinical confocal microscopy animal rights rabbit cornea human cornea human clinical effects toxic animal rights activist sensitive measures toxic effect toxicity threshold agar overlay agar diffusion agar overlay method agar diffusion method cytochrome cytochrome c apoptosis necrotic apoptotic necrosis caspase rhodamine 123 resazuran resorufin cell death cell viability metabolic dye microsomal microsomal enzymes cytotoxicity cytotoxic cytotoxic effect MTT XTT WST-1 plasma membrane mitochondrial mitochondrial morphology ocular toxicity potential ocular toxicity human corneal epithelial cell line confocal analysis corneal epithelium cell fluorescence alamarBlue assay rhodamine dye animal welfare toxic injury degraded mitochondria epithelial monolayer disinfectants membrane integrity eye toxicity eye viability dye toxicity in humans human toxicity effects on the mitochondria mitochondrial toxicity in vitro battery in vitro test battery ophthalmic eye drop direct contact product safety cytotoxicity potential molecular molecular biology refine reduce replace sensitivity and relevance sensitivity relevance rabbit ocular irritation test product development cytotoxicity models cytotoxicity alternative methods replacements for animal testing three r's beagle tiered testing tiered testing strategy replacements animal testing mechanistic toxicity cornea mitochondria dose response threshold Vision Science and Biology

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