Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / O principal objetivo do presente trabalho consiste em demonstrar que, segundo a Lógica, a Filosofia do Espírito e a Estética de Hegel, os âmbitos da natureza e do espírito, tal como descritos pelo autor, não podem ser concebidos como âmbitos isolados entre si, mas devem ser tidos antes como domínios interligados por dois importantes fundamentos conceituais, a saber: em primeiro lugar, Hegel concebe tanto o espírito quanto a natureza como modos de manifestação da Ideia Absoluta; em segundo lugar, Hegel define a natureza como o espírito alienado de si. Sendo assim, investigaremos em que consiste tal estado de alienação e o modo como o mesmo se torna evidente em meio às considerações do autor sobre a natureza, bem como o modo pelo qual tal alienação é, por assim dizer, superada pelo próprio espírito imanente à natureza, superação esta que o conduz ao reino da consciência. Entretanto, é importante ter em mente desde já que a suspensão deste estado de alienação não ocorre de forma repentina: ao contrário, a assim chamada des-alienação do espírito se dá por meio de um processo gradual, onde a essência espiritual da natureza se torna mais manifesta à medida que o auto-movimento torna-se perceptível como algo imanente aos seres naturais, tendo como ápice de sua manifestação a natureza orgânica. Nesta forma de existência natural, a alma ― termo cunhado a partir do termo latino anima, a fonte de animação dos organismos em geral ― lhes empresta a vitalidade que lhes é própria, vitalidade esta que, como veremos, consiste na forma de expressão mais elevada da presença do espírito na natureza. / This dissertation aims at demonstrating that, according to Hegels Logic, Philosophy of Spirit and Aesthetics, the domains of nature and spirit cannot be conceived as two completely isolated domains, but rather as domains which are intimately connected by two important conceptual grounds, namely, the fact that Hegel conceives both nature and spirit as two modes of manifestation of the Absolute Idea and the fact that Hegel defines nature as the spirit existing as alienated from itself. In this way, we shall analyze such state of alienation, in order to clarify exactly what it is and how it expresses itself among the authors descriptions of the natural realm; besides, we shall also investigate how such alienation is, so to speak, overcome by the spirit lying within the essence of nature, which leads to the rise of consciousness. However, according to Hegel, the overcoming of such state of alienation is not something that happens instantly: on the contrary, it consists in a gradual process, in which the immanent spiritual essence of nature unfolds itself and becomes more clearly manifested as the property of self-movement begins to be acknowledged as something inherent to the natural beings, organic nature being the apex of spirits manifestation within nature. In the realm of organic nature, the soul a term that is related to the Latin word anima, the source of animation of organisms in general grants them the vitality which characterizes them as living beings; as we shall see, this vitality is the most elevated way of the spirits manifestation within nature.

Made available in DSpace on 2016-04-27T17:27:03Z (GMT). No. of bitstreams: 1 Marco Antonio Chabbouh Junior.pdf: 1163932 bytes, checksum: a475e7e1b94aa998f468457e35783e1d (MD5) Previous issue date: 2012-10-29 / Conselho Nacional de Desenvolvimento Científico e Tecnológico / One of the best-known teachings of the Critique of Pure Reason by Immanuel Kant is that of the ideality of space and time. The present work aims at discussing the relations between the proofs of the apriority of space and time and the proofs of their subjective character. To achieve this aim, the present text takes the form of a comparative and commented exposition of the readings by Norman Kemp Smith, Herbert James Paton and Patricia Kitcher. This exposition is made in three main chapters. The first one is intended to make an approach to the main problem, the second one is a detailed discussion of the mentioned readings and the third one is constituted by the position taking from the offered debate. It intends then, to demonstrate that Paton s interpretation is the most successful among the three, because it is able to solve pressing problems enunciated by Kemp Smith without trespassing, as Kitcher did, the boundaries of the critical text. Hence, it is also shown that the ideality of space and time intended by Kant is not made through a doctrine of innate ideas similar to the rationalist ones, but is only a doctrine that states the existence of an innate capacity responsible for the production of pure spacial and temporal contents once experience begins / Um dos mais célebres ensinamentos da Crítica da Razão Pura de Immanuel Kant é o da idealidade do espaço e do tempo. O presente trabalho tem como objetivo discutir as relações existentes entre as provas a favor da aprioridade do espaço e do tempo e as provas a favor de seu caráter subjetivo. Para levar a cabo a tarefa citada, o presente texto toma a forma de uma exposição comparativa e comentada das interpretações de Norman Kemp Smith, Herbert James Paton e Patricia Kitcher. Essa exposição faz-se em três capítulos. O primeiro é uma aproximação ao problema central, o segundo constitui-se de uma discussão em detalhe das interpretações analisadas e o terceiro consiste na tomada de posição a partir da discussão oferecida. Pretende-se mostrar que a leitura feita por Paton é a mais bem sucedida dentre as três por conseguir dar conta de importantes questões postuladas por Kemp Smith sem extrapolar, como fez Kitcher, os limites textuais. Sendo assim, evidencia-se que a idealidade do espaço e do tempo pretendida por Kant não se constitui a partir de uma doutrina que afirma a existência de ideias inatas nos moldes racionalistas dogmáticos, mas que afirma unicamente a presença de uma capacidade inata responsável por produzir conteúdos espaciais e temporais puros mediante a experiência

This study offers the first comprehensive account of the problem of situation-dependence and facticity in Husserl's phenomenology of meaning. On the basis of a reconsideration of the central ideas of Husserl's phenomenological approach to meaning and intentionality, it presents a reconstruction and assessment of Husserl's revised conception of empirical meaning. Taking its lead from Husserl's self-critical remark on the analysis of "occasional expressions" in the Logical Investigations, the study uncovers the underlying problem with Husserl's initial conception of the relation between subjectivity and objectivity. It is shown that the problem of occasionality does not relate to indexicality in a standard sense, but to the essential facticity and subject-relativity of the intentional individuation of real being in general and to the contingency and inexhaustible transcendence of the world. The reconstruction of Husserl's solution is carefully related to an interpretation of central ideas of Husserl's developed philosophy. Critically reviewing influential interpretations of Husserl, the study elaborates on the question of internalism and externalism, the question of representationalism, the question of ideal contents, the notion of noema and the issues of direct reference and de re meaning. It is shown how Husserl's revised conception of empirical meaning is related to the analysis of horizon-intentionality, to the constitution of the transcendent real world and to the constitution of the lived body as a centre of situated orientation. It is argued that Husserl succeeds in maintaining phenomenological internalism with regard to intentionality in concreto, while accepting a form of externalism with regard to meaning, according to which the possibility of true identity of meaning is bound to the presumptive existence of the experienced world.

The Flory ideality hypothesis states that flexible polymer chains in a melt assume the shape of three-dimensional random walks leading to so called Gaussian coils. The basis of this hypothesis is that any local conformational information decays exponentially along the chain backbone and thus has no influence on the long range conformation. Additionally it is argued that the excluded volume shielding of neigbor chains cancels out any swelling effects. Neutron scattering (NS) experiments dating back 30 years confirm the postulated Gaussian coil shape of polymers. This leads to a pillar of polymer theory: Any flexible polymer can be described as a three-dimensional random walk. Advances in simulation technics and computing power have opened the door to the possibility of studing very long chains. This allowed for a closer look at the chain structure of polymer melts and revealed deviations from ideality. This deviation is very slight and thus great care must be taken to distinguish it from noise. So far the deviation from the Gaussian coil structure was only studied for coarse-grained models. The scope of this thesis is to explore if these deviations are also measurable in atomistically realistic simulations and modern day NS experiments.

This thesis is basically an attempt to discuss the intrinsic intersubjective nature of the so-called ideal sciences, i.e. geometry or arithmetic. Based upon a thorough analysis of Husserls The Origin of Geometry and Derridas Edmund Husserl's Origin of Geometry: an Introduction this thesis takes geometry as an example of an ideal science. The main question of the thesis is how an ideal science or object is constituted. The thesis consist of two main chapters - “Geometry and Historicity” and “Language”- and a concluding discussion. "Geometry and Historicity” reflects upon the relationship between the ideal sciences, using geometry as an example, and historicity, time and traditionality." The “Language” chapter discusses the need for language to make communication within an intersubjective space possible", and further which implications writing has upon the formations of ideal structures. To conclude the thesis demonstrates how geometry is far from a 'neutral' science but is constituted and idealized within the intersubjective space. The thesis argues that geometry has been “traditionalized” as an authentic and, as it is conceived, true form of knowledge through a historical process of human relations. This is made possible with the intrinsic “objectifying” ability within language and more specifically the human literacy, which is essential for this “idealization” process. As a consequence our understanding of science needs further reflections on how language, historicity and ultimately human relations have played an essential part in its formation.

Selon l’hypothèse d’idéalité de Flory, les chaînes de polymères flexibles à l’état fondu se présentent sous la forme de marches aléatoires à trois dimensions, aussi appelées pelotes gaussiennes. Cette hypothèse suppose que toute information relative à la conformation locale subit une décroissance exponentielle le long de la chaîne principale et, par conséquent, n’a aucune influence sur la conformation à grande échelle. De plus, il est avancé que l’écrantage du volume exclu par les chaînes voisines compense tout effet de gonflement. Des expériences de diffusion neutronique (DN) effectuées il y a une trentaine d’années confirment que les polymères adoptent bien des configurations gaussiennes. S’ensuit l’un des piliers de la théorie des polymères : En solution ”suffisamment dense” tout polymère flexible peut être décrit comme une marche aléatoire à trois dimensions, indépendamment de sa structure chimique, et ce, après un rééchelonnage adéquat. Les progrès réalisés dans les domaines des techniques de simulation et de la puissance informatique ont rendu possible l’étude de chaînes très longues. Ceci a permis d’observer de plus près la structure des chaînes de polymère à l’état fondu et révélé une déviation par rapport à la chaîne idéale. Jusqu’à présent, la déviation par rapport à la structure gaussienne a uniquement été étudiée dans le cas de modèles à gros grains, par simulation et calcul analytique. La présente thèse cherche à vérifier si ces déviations peuvent également être mesurées à l’aide de simulations atomistiques réalistes et d’expériences de DN modernes. / The Flory ideality hypothesis states that flexible polymer chains in a melt assume the shape of three-dimensional random walks leading to so called Gaussian coils. The basis of this hypothesis is that any local conformational information decays exponentially along the chain backbone and thus has no influence on the long range conformation. Additionally it is argued that the excluded volume shielding of neigbor chains cancels out any swelling effects. Neutron scattering (NS) experiments dating back 30 years confirm the postulated Gaussian coil shape of polymers. This leads to a pillar of polymer theory: Any flexible polymer can be described as a three-dimensional random walk. Advances in simulation technics and computing power have opened the door to the possibility of studing very long chains. This allowed for a closer look at the chain structure of polymer melts and revealed deviations from ideality. This deviation is very slight and thus great care must be taken to distinguish it from noise. So far the deviation from the Gaussian coil structure was only studied for coarse-grained models. The scope of this thesis is to explore if these deviations are also measurable in atomistically realistic simulations and modern day NS experiments.

Metal-semiconductor contacts have been widely studied in the past 60 years. These structures are of importance in the microelectronics industry. As the scaling down of silicon-based complementary metal-oxide-semiconductor (CMOS) devices becomes more and more challenging, new material and device structures to relax this physical limitation in device scaling are now required. Germanium (Ge) has been proposed as a potential alternative to silicon. In this thesis a systematic study of the thermally induced reaction of transition metals with the n-Ge substrate is outlined. Investigations in the change of the electrical properties of the metal germanide structures is studied in a wide range of temperatures. Current-voltage (I-V), capacitance-voltage (C-V), deep level transient spectroscopy (DLTS) and high-resolution Laplace-DLTS (L-DLTS) techniques have been used for the electrical characterization of the fabricated Schottky contacts. Results obtained indicate the variation of the electrical properties of these Schottky contacts can be attributed to combined effects of interfacial reactions and phase transformation during the annealing process. The barrier height distribution in identically prepared Schottky contacts on n-Ge (100) showed that the barrier heights and ideality factors varied from diode to diode even though they were identically fabricated. The properties of the n-Ge Schottky contacts have revealed a strong dependence on temperature. The current transport mechanism has been shown to be predominantly thermionic emission at high temperatures while at low temperatures, the Schottky contacts have exhibited the dominance of the generation-recombination current mechanism. The variation of the Schottky barrier heights at low temperatures have been attributed to barrier inhomogeneities at the metal-semiconductor (MS) interface. Results from defect characterization by DLTS show that the E-centre is the dominant defect introduced in n-Ge by electron beam deposition during contact fabrication and substitutional related defects are induced during the annealing process. The identification of some of the defects was achieved by using defect properties, defect signature, annealing mechanisms and annealing behaviour and comparing these properties to the results from theoretical defect models. Annealing showed that defects in Ge can be removed by low thermal budget of between 250–350°C. Finally, structural characterization of these samples was performed by scanning electron microscopy (SEM) and Rutherford backscattering spectrometry (RBS) techniques. From the SEM images it can be observed that the onset temperature for agglomeration in the 30 nm Ni/n-Ge (100), and Pt/-, Ir/- and Ru/n-Ge (100) systems occur at 500–600°C and 600–700°C, respectively. / Thesis (PhD)--University of Pretoria, 2010. / Physics / unrestricted

This thesis presents four-quadrant CMOS current-mode multiplier architectures based on the bipolar Gilbert cell multiplier architecture. Multipliers are designed using the CMOS subthreshold region to take advantage of the subthreshold exponential I-V relationship that closely matches bipolar modeling. It is discovered that biasing to remove drift current components and to address higher order effects such as ideality factor mismatch, threshold mismatch, body effect, and short channel effects, is important to provide a linear multiplier. It is also shown that distortion caused by device size mismatch and offset input currents can be used to cancel the distortion introduced by drift currents when designing in weak and moderate inversion. This concept allows for linear multiplier designs with larger input currents which results in dramatic improvements in bandwidth over traditional weak inversion circuits. Three multiplier circuits are simulated and fabricated in an AMIS 0.35-um process. Circuits with less than 1 % nonlinear error and distortion (THD) across 100 % dynamic input range and with bandwidths greater than 100 MHz can be built. Also, low power multiplier solutions are presented that consume less than 40 nW of dynamic power.

La drépanocytose, ou anémie falciforme, présente une variabilité interindividuelle considérable, conditionnée par de multiples facteurs, dynamiques et interactifs, depuis le niveau moléculaire jusqu’au niveau du patient. L’hémoglobine drépanocytaire, ou hémoglobine S (HbS, tétramère a2bS 2), est un mutant de l’hémoglobine A (a2b2) : elle possède à sa surface une valine (hydrophobe) substituant un acide glutamique natif (négativement chargé). Cette mutation entraîne l’agrégation de l’HbS désoxygénée en polymères, ainsi que l’altération des propriétés de l’érythrocyte -dont sa rhéologie et ses interactions avec les différentes cellules vasculaires. C’est pourquoi la polymérisation de l’HbS constitue un facteur étiologique clef, sinon le primum movens, de la drépanocytose, et une hypothèse thérapeutique (étayée par l’observation) postule que la réduction des fibres intra-érythrocytaires de HbS pourrait améliorer le statut clinique des patients en abaissant la fréquence et la sévérité des crises vasoocclusives. Dans l’optique de mieux comprendre et de mieux gérer la variabilité individuelle drépanocytaire, il apparaît donc indispensable de disposer, en premier lieu, d’une description réaliste de la polymérisation de l’HbS. L’objectif de ce travail de thèse est la mise en place et la validation d’un modèle mathématique de la polymérisation de l’HbS désoxygénée, en tant que processus cinétiquethermodynamique, sous l’influence de la concentration et de la température –les deux facteurs modulateurs les plus importants. A partir d’un modèle existant, mais linéaire et incomplet (Ferrone et al., 1985), nous avons procédé à son implémentation, à sa correction et à sa mise à jour, ainsi qu’à l’évaluation quantitative de ses performances dynamiques, par intégration complète et simulation numérique (Simulink©). Ceci nous a permis de réaliser un diagnostic et d’effectuer un certain nombre de raffinements, concernant en particulier (i) la voie de nucléation hétérogène (formation de néo-fibres sur les fibres préexistantes), (ii) la non-idéalité de la solution protéique de HbS, induite par le volume exclus des fibres polymères (coefficients d’activité calculé à partir de la « théorie des particules convexes »), ainsi que (iii) la structuration spatiale des polymères en domaines. Le modèle développé dans ce travail servira de base pour une description (i) de l’influence dynamique de l’oxygénation et des hémoglobines non-polymérisantes sur la polymérisation de HbS, puis (ii) des polymères de HbS sur les propriétés membranaires et rhéologiques de l’érythrocyte drépanocytaire. / Sickle cell disease pathology exhibits a strong interindividual variability, which depends upon multiple, dynamic and interacting factors, from the molecular to the patient level. Sickle hemoglobin, hemoglobin S (HbS, a2bS 2 tetramer), is a mutant of HbA (a2b2), with a surface valine (hydrophobic) substituting a native glutamic acid (negatively charged). Such a mutation endows deoxygenated HbS with the propensity to agregate into polymers, altering erythrocyte properties –including its rheology and its interactions with vascular and circulatory cells. Thus HbS polymerization is a key etiological factor of sickle cell disease, if not the primum movens. Indeed, one therapeutical hypothesis (supported by observation) postulates that the reduction of intra-erythrocytic HbS fibers could improve patients clinical status by lowering the frequency and the severity of vasooclusive crisis. In order to better understand and manage sickle cell disease variability, it is essential to have a realistic description of HbS polymerization. This work aims at developing and validating a mathematical model of deoxygenated HbS polymerization, as a kinetic and thermodynamic process under the influence of concentration and temperature –the two most important modulators. Building on an existing, but linearized and uncomplete (Ferrone et al., 1985) model, we have implemented, corrected and updated, and quantitatively evaluated its dynamical performances: this was done by full numerical integration using Simulink©. This allowed us to make several improvements, related in particular to : (i) the heterogeneous nucleation pathway (seeding and formation of new fibers from pre-existing ones), (ii) the non-ideality of the HbS protein solution, caused by polymer fibers excluded volume (activity coefficients were calculated with the CPT, Convex Particle Theory), and (iii) the spatial organization of polymers into domains. The model developped in this work will ground the description of the dynamic influence (i) oxygenation and non-polymerizing hemoglobins, (ii) HbS polymers interactions with membrane and consequences upon rheological properties of sickle cell erythrocyte.

康德主張，空間的「先驗的觀念性」，並且此一觀念性是可以與「經驗的實在性」相容。對於「先驗的觀念性」，處於空間的事物被限定於感性的對象上，即是顯象，因此並不適用在那些「當它們得以透過理性其自身，即是毫無顧及我們感性的狀態」的內容。同樣地，「經驗的實在性」所刻劃的是外在顯象，如同康德在上述引文所指，乃是「在考慮一切可能的外在經驗」。據此，所謂空間的「先驗的觀念性」，從「觀念性」而言，空間是先天的直覺形式，故不屬於對象或事物自身的任何屬性。不過此一空間的觀念性，即先天的直覺形式，乃是任何外在顯象得以可能的條件，所以空間的觀念性，雖是感性主體的認知條件，卻不能等同於僅僅是主觀的觀念性，而是具有先驗條件的觀念性，也就是其是一種先天可能的認知模式，因此，空間的觀念性，乃是「先驗的」，這是康德稱空間為「先驗的觀念性」所持的立場。與此同時，對康德來說，空間的「先驗的觀念性」，則蘊含空間的「經驗的實在性」。從康德看來，我們要意識到任何外在經驗，皆必定在空間秩序關係中被呈現或給與出來，如此一來，空間具有「實在性」。不過，空間的「實在性」其效力僅對於我們外感官的經驗對象才能有效，並無法對事物自身產生任何約束，所以空間的「實在性」，就祇能是屬於經驗的，我們不能將空間的「實在性」歸屬在事物自身。 / Kant advocates the view that space is transcendental ideality and empirical realtiy. This article aims at interpretation of Kant’s space thesis. Kant attempts to offer argument transcendental ideality of space mean that space is subjective and limiting condition to which human intuition. This implication that kant asserts transcendental ideality thesis is that space has limited to appearance, and when applied to the things in themselves, space is merely an idea,or equivalently that is transcendental. However transcendental ideality of space does not mean that objects within of space is nothing, only ideas of our mind. In contrast to this, transcendental ideality thesis as equivalent to empirical reality of space ,that is said to regard space is real, but which is objective validity limited by applicable to outer appearances.