La maladie de Parkinson est la seconde pathologie neurodégénérative la plus fréquente après la maladie d’Alzheimer. Elle se manifeste par une mort progressive et continue des neurones dopaminergiques de la voie nigro-striée, accompagnée de troubles moteurs et non moteurs lourdement handicapants. La maladie de Parkinson touche près de 6,3 millions de personnes dans le monde, avec une répartition homogène sur l’ensemble de la planète. Il existe plusieurs thérapeutiques permettant de diminuer les symptômes des malades, dont les plus efficaces sont la dopa-thérapie et la stimulation cérébrale profonde. Toutefois, à ce jour, aucune stratégie visant à protéger les neurones dopaminergiques de la dégénérescence n’a démontré son efficacité chez l’humain. En parallèle, un nombre grandissant d’études montre le potentiel cytoprotecteur d’une illumination proche infrarouge. Récemment, plusieurs études ont démontré le potentiel neuroprotecteur de cette gamme de lumière sur des modèles rongeurs de la maladie de Parkinson. L’objectif du présent travail est de confirmer ce potentiel et d’optimiser son efficacité afin de préfigurer l’essai clinique à venir. Pour ce faire, avec les modèles MPTP souris et 6-OHDA unilatéral rat, nous avons étudié la faisabilité d’une illumination intracérébrale chronique, l’influence de la longueur d’onde, de la fenêtre temporelle de traitement (pré-, post-traitement), de la quantité globale d’énergie optique apportée (continu vs discontinu, nombre de flashs lumineux, énergie d’un seul flash), de la durée d’un flash et de la puissance optique appliquée sur l’efficacité thérapeutique. Nous démontrons ici la faisabilité d’une illumination intracérébrale chronique et son potentiel neuroprotecteur. Nous montrons par ailleurs que les longueurs d’onde 670 et 810 nm protègent toutes deux les neurones dopaminergiques dans nos modèles d’étude. Nous montrons une mise en place rapide des mécanismes de protection (< 20 min), et un maintien dans le temps pendant au moins 48 heures. De plus, nous observons qu’une illumination discontinue est préférable à une illumination continue. La quantité globale d’énergie optique appliquée semble ne pas avoir de rôle significatif sur l’efficacité du traitement. En revanche, il existe un seuil bas pour la puissance optique, qui semble régie par un effet « tout-ou-rien ». L’efficacité thérapeutique est également liée à la durée d’un flash lumineux, par « un effet en cloche », Tous ces résultats sont en adéquation avec la littérature scientifique qu’ils confirment et complètent. Couplés aux travaux sur primates non humains de mon équipe d’accueil, ils serviront de base de travail à la conception du futur essai clinique. / Parkinson’s disease is the second most common neurodegenerative disease, after Alzheimer disease. It is characterized by a slow, continuous death of dopaminergic neurons in the nigrostriatal pathway, followed by severe motor and non-motor symptoms. Parkinson’s disease affects 6.3 million peoples, with a homogeneous distribution worldwide.There are several symptomatic strategies applied in clinic, such as the dopa-therapy (gold standard) and the deep brain stimulation. However, theses therapeutical approaches are not neuroprotective. Indeed, to date, there is no strategy able to effectively slow or rescue the course of the disease. Alternatively, a growing number of studies show the cytoprotective potential of a near infrared illumination. Recently, several studies showed the neuroprotective potential of these wavelengths in rodent models of Parkinson disease.The aim of this work is to confirm and optimize the efficacy of a near infrared treatment in Parkinson’s disease, as the first step for the future clinical trial.We used the MPTP mice and the 6-OHDA unilateral rat models to assess the feasibility and the effectiveness of an intracerebral chronical illumination. We also measured the influence of the wavelength, the time window (pre-, post-treatment), the global optical energy delivered (continuous vs discontinuous, number of flashs, energy of one flash), the duration of one flash and the optical power on the therapeutical efficacy.We demonstrate here the feasibility of an intracerebral chronical illumination and its neuroprotective potential. We show that the 670 and 810 nm wavelengths both protect the dopaminergic cells in the rodent models, and produce a quick activation of the protective mechanisms (< 20 min). The neuroprotective effect stays effective at least 48 hours after the illumination. Moreover, we show that a discontinuous illumination seems better than a continuous one. The global optical energy delivered has no significant influence on the efficacy. In contrast, the optical power has an everything-or-nothing effect. The therapeutic efficacy is also flash duration dependent (bell effect).All these results confirm and complete the scientific literature. Together with the work on non-human primates from my team, these results will be useful to design the future clinical trial.

Made available in DSpace on 2016-04-26T20:25:50Z (GMT). No. of bitstreams: 1 Fabio Ferreira Kujawski.pdf: 480443 bytes, checksum: b2d82d3b47867049534ee9a312d7ec44 (MD5) Previous issue date: 2007-09-12 / Issues concerning private investment in infrastructure projects, all over the world, are always very challenging. There are many reasons for this, since infrastructure projects depend on the conjoining of a variety of factors that must be present simultaneously, so that the sensitive private interest can be secured for projects of such complexity and often of a long-term and capital intensive nature. We intend to show that a country's success or failure in attracting private investment in infrastructure projects depends largely on there being a stable regulatory environment, administrative efficiency and trust in relations between the government and the private parties / Questões relativas a investimentos privados em projetos de infra-estrutura, em qualquer parte do mundo, são sempre muito desafiadoras. Razões para isso não faltam, pois esses projetos dependem de um plexo de fatores conjunturais que devem coexistir em um mesmo momento, para que o sensível interesse privado possa ser capturado por projetos de tal complexidade e, freqüentemente, de longo prazo e capital intensivo. Pretendemos demonstrar que o sucesso ou insucesso das nações em atrair investimentos privados em projetos de infra-estrutura depende, em grande medida, da existência e estabilidade de um marco regulatório, da eficiência administrativa e da confiança nas relações travadas entre a Administração Pública e o particular

Made available in DSpace on 2016-04-26T20:48:54Z (GMT). No. of bitstreams: 1 Cassia Bomer Galvao.pdf: 2047067 bytes, checksum: cfb867c00398e0daa9359f0216bcd1f4 (MD5) Previous issue date: 2009-04-29 / Instituto de Pesquisa Econômica Aplicada / The aim of this study is to analyze the changes in the maritime ports sector considering the recent economic liberalization with consequent substantial growth in the international trade and therefore increasing demand for sea transport of goods. This situation leads to a reflection about its determinant factors and consequences as it is evident that the growth in the international trade not followed by growth in the global production has caused several changes in the transport infra-structure, especially in the port sector. This process was particularly accelerated during the 1990 s, but the changes in the transport have started already in the 1980 s with the general usage of the containers. In this context, the role of maritime ports become more important, as they are the preferential mode used for the international trade transactions. The ports, therefore reveal to be (among other factors) key element for the competitiveness of international prices. Thus, as all these chances are not caused by an abstract or independent modernization wave, but they belong to a major context of new economic scenario (the globalization); it is relevant to know the details of this new port infrastructure. In the case of Brazilian ports there are two issues in focus: first the changes promoted by the Modernization Law (1993), considered to be the main legal document in the new port management and format in Brazil; and second the perspectives for the port sector in the future, considering the new investment proposition in the PNLT (National Plan for Logistics and Transport). The results of this study show that the ports have an essential role in the new logistics concept, which was developed to attend the need of new lean production. This means that the port reforms, made during the 1990 s, present a deep relation with dislocation phenomenon and globalization of capital / Este trabalho tem como objetivo analisar as transformações no setor portuário a partir do momento em que ocorreu a liberalização das economias com aumento expressivo do comércio exterior e consequente incremento no volume mercadorias sendo transportada por via marítima. Essa realidade exige uma reflexão sobre seus determinantes e suas conseqüências, pois a evidência de que um grande crescimento das transações comerciais mundiais não acompanhadas por um crescimento da produção mundial na mesma proporção, provocou transformações no setor de transportes, em especial na infra-estrutura portuária. Essa situação foi especialmente acelerada nos anos 1990, mas o processo de transformação nas condições de transporte já se alterava desde a década de 1980 com a generalizaçaõ do uso do contêiner. Neste cenário, a questão do papel dos portos marítimos, ganha destaque, uma vez que são os meio preferenciais para o comércio exterior e, portanto, elemento-chave, junto com outros, na determinação da competitividade dos preços dos produtos nacionais. Assim, como essas mudanças não se justificam por uma necessidade abstrata de modernização, e sim estão contextualizadas em uma nova realidade econômica mundial, torna-se relevante conhecer em detalhe os determinantes desse novo entorno e dessa nova estrutura. No caso brasileiro estuda-se principalmente duas questões: a primeira relativa às mudanças a partir da lei de modernização dos portos (1993) que se coloca também como um divisor de águas na gestão e reformulação do setor portuário no país; e a segunda, referente às perspectivas para o futuro considerando as propostas do PNLT (Plano Nacional de Logística de Transporte). O que se verificou é que os portos possuem papel relevante no novo conceito de logística que se desenvolveu para atender as novas necessidades de estoques mais enxutos. Isto é, as reformas portuárias durante a década de 1990 possuem profunda relação com o fenômeno da deslocalização e da mundialização do capital

A análise pelas técnicas hifenadas CLAE-DAD-EM e CLAE-DAD-EM/EM de extratos foliares de Lychnophora ericoides Mart. levou à identificação de 34 metabólitos secundários diretamente a partir dos extratos vegetais. Destes, 19 foram relatados pela primeira vez na subtribo Lychnophorinae. Uma metodologia para extração e análise destes metabólitos por CLAE-DAD foi desenvolvida, validada e utilizada para determinação de suas variações populacionais e temporais. Perfis metabólicos bem semelhantes, com diferenças quantitativas, mas não qualitativas, foram observados entre os indivíduos de uma mesma população. Entre as cinco populações analisadas, foi observado um metabolismo secundário bem mais diversificado, caracterizado pela presença de lactonas sesquiterpênicas, nas plantas da população de Ibiraci-MG. As concentrações mais elevadas de ácidos cafeoilquínicos foram encontradas no período da seca no cerrado (inverno) e as menores quando a planta se encontrava florida. Os teores de flavonóides foram maiores durante o período de chuvas (verão) e os de C-glicosilflavonas e lactonas sesquiterpênicas se mantiveram estáveis. Variações circadianas significativas de flavonóides e ácidos cafeoilquínicos também foram observadas nas duas populações nas quais estes fatores foram estudados. Foi verificado que o envelhecimento das folhas resulta em uma pronunciada redução no conteúdo de todos os metabólitos secundários e concentrações menores dos metabólitos foram observadas nas folhas dos ramos floridos em relação aos ramos sem flores de um mesmo indivíduo. Finalmente, conclui-se que as variações temporais e populacionais observadas em L. ericoides podem ser determinantes para a intensidade da atividade antiinflamatória e/ou analgésica desta planta, utilizada popularmente para estes propósitos. / The analyses of Lychnophora ericoides Mart. leaves extracts by HPLC-DAD-MS and HPLC-DAD-MS/MS resulted in the identification of 34 secondary metabolites directly from the plant extracts. Nineteen of these metabolites are being reported for the first time in the Lychnophorinae subtribe. A method for the extraction and analyses of these metabolites by CLAE-DAD was developed, validated and employed for the determination of their populational and temporal variations. Very similar metabolic profiles, exhibiting quantitative but not qualitative differences, were found among each population individuals. Among the five studied populations, a more diversified secondary metabolism, characterized by sesquiterpene lactones presence, was observed for the plants collected at Ibiraci-MG. The highest concentrations of caffeoylquinic acids were found in the cerrado dry season (winter), and the lowest when the plants were blooming. The flavoinoid contents were higher during the rainy season (summer), while C-glucosylflavones and sesquiterpene lactones levels remained stable. Significant circadian variations were also detected regarding flavonoids and caffeoylquinic acids in the two populations analyzed on this respect. It was also found a pronounced reduction in the contents of all the secondary metabolites as the leaves get old. Lower levels of all the metabolites were also found for the flowery branches when compared to the non flowery ones in the same individual. Finally, it can be concluded that the temporal and populational variations detected in L. ericoides leaves could highly influence the intensity of the anti-inflammatory and/or analgesic activities of this plant, used in popular medicines for these purposes.

Os pólos industriais são uma realidade no Brasil, mas, do ponto de vista da legislação, carecem de um tratamento específico e claro, particularmente com relação ao compartilhamento da infra-estrutura e aquisição de insumos energéticos. A falta de clareza na regulamentação brasileira abre espaço para interpretações divergentes com relação ao suprimento energético, que muitas vezes acaba prejudicando a captura de sinergias e ganhos de escala nos pólos industriais, principalmente para as empresas menores. Este cenário gera incerteza com relação aos preços finais de energia e reduz, de forma artificial, os benefícios inerentes à formação de pólos industriais. A adequação na legislação do setor elétrico brasileiro é fundamental para se criar um ambiente regulatório que defina de forma clara e objetiva soluções para a questão energética nos pólos industriais. Neste trabalho apresentam-se proposições de inovações na legislação do setor elétrico brasileiro que poderiam criar um ambiente regulatório transparente e seguro às empresas, no que se refere ao suprimento elétrico, compartilhamento de infra-estrutura e aquisição de energia elétrica em pólos industriais. As inovações propostas preservam as condições de suprimento elétrico dos pólos existentes e também incentivam a criação de novos pólos. / Industrial cluster systems are a reality in Brazil but Brazilian electric regulation does not have a specific and clear treatment about industrial cluster electric supply, especially regarding infra-structure common usage and group energy purchase. This lack of regulation generates a scenario of uncertainty about the energy costs for companies placed in Industrial cluster systems, and reduce, in an artificial way, the advantages that industrial clusters naturally has. The modification in Brazilian electric regulation is fundamental to define energy policies aspects for industrial clusters, to provide a safe environmental for existents industrial clusters and to generate conditions to create new ones. In this dissertation, innovations in Brazilian electric regulation are presented aiming to create a safe and clear environmental for industrial clusters. The proposed innovations preserve the electric supply conditions for the existents industrial clusters and support the creation of new sites, where two or more industries can share electric infra-structure and purchase energy together.

Os pólos industriais são uma realidade no Brasil, mas, do ponto de vista da legislação, carecem de um tratamento específico e claro, particularmente com relação ao compartilhamento da infra-estrutura e aquisição de insumos energéticos. A falta de clareza na regulamentação brasileira abre espaço para interpretações divergentes com relação ao suprimento energético, que muitas vezes acaba prejudicando a captura de sinergias e ganhos de escala nos pólos industriais, principalmente para as empresas menores. Este cenário gera incerteza com relação aos preços finais de energia e reduz, de forma artificial, os benefícios inerentes à formação de pólos industriais. A adequação na legislação do setor elétrico brasileiro é fundamental para se criar um ambiente regulatório que defina de forma clara e objetiva soluções para a questão energética nos pólos industriais. Neste trabalho apresentam-se proposições de inovações na legislação do setor elétrico brasileiro que poderiam criar um ambiente regulatório transparente e seguro às empresas, no que se refere ao suprimento elétrico, compartilhamento de infra-estrutura e aquisição de energia elétrica em pólos industriais. As inovações propostas preservam as condições de suprimento elétrico dos pólos existentes e também incentivam a criação de novos pólos. / Industrial cluster systems are a reality in Brazil but Brazilian electric regulation does not have a specific and clear treatment about industrial cluster electric supply, especially regarding infra-structure common usage and group energy purchase. This lack of regulation generates a scenario of uncertainty about the energy costs for companies placed in Industrial cluster systems, and reduce, in an artificial way, the advantages that industrial clusters naturally has. The modification in Brazilian electric regulation is fundamental to define energy policies aspects for industrial clusters, to provide a safe environmental for existents industrial clusters and to generate conditions to create new ones. In this dissertation, innovations in Brazilian electric regulation are presented aiming to create a safe and clear environmental for industrial clusters. The proposed innovations preserve the electric supply conditions for the existents industrial clusters and support the creation of new sites, where two or more industries can share electric infra-structure and purchase energy together.

Les gisements de type roll-front du Kazakhstan représentent près de 13% des réserves mondiales en uranium en 2015. Les minéraux argileux, présents à chaque étape du cycle minier, ont récemment suscité l’intérêt des exploitants. L’étude de la distribution et des proportions de ces minéraux dans les sédiments à l’échelle d’un gisement permettraient d’améliorer à la fois l’exploration, l’exploitation et la réhabilitation de ce type de gisement.Différentes méthodes ont été développées pour identifier et quantifier les minéraux d’intérêt à partir de la spectrométrie infrarouge (IR), une technique instrumentale rapide, adaptée à une utilisation sur le terrain. Ces méthodes ont été calibrées à l’aide d’une large base de données de spectres IR et la préparation de sables artificiels.Il est possible d’obtenir, à partir d’une seule mesure spectrale, la teneur en argiles des sables et particulièrement celle en smectite afin d’identifier les zones les plus riches et adapter l’extraction de l’uranium. L’ensemble de ces méthodes permettent de réaliser des cartographies de la répartition des minéraux argileux à l’échelle du gisement pour comprendre sa géométrie et sa mise en place.La migration des corps minéralisés à l’échelle régionale a été mise en évidence par spectrométrie de résonance paramagnétique, avec l’étude des défauts structuraux engendrés par la proximité des minéraux argileux avec les minéraux uranifères. / Uranium roll-front type sandstone-hosted deposits from Kazakhstan account for about 13% of the worldwide uranium reserve in 2015. Clay minerals occur at every step of the mining cycle and recently begun to be considered by mining companies.The proportions and distribution of these clay minerals in the sediments at the roll-front deposit scale could improve the exploration, exploitation and rehabilitation of such uranium deposits.Several methods were developed to identify and quantify minerals using a portable near-infrared spectrometer, a convenient and fast analytical tool for use in the field. These methods were calibrated with the help of a wide spectral database and the conception of artificial sands.The clay mineral content, and more importantly, the smectite content can be obtained from a single spectral measurement. It enables the detection of smectite-rich areas to optimise the uranium extraction process where they occur. Combination of the methods provide a mapping tool for clay minerals at the ore deposit scale, yielding information about its actual geometry and formation.Uranium ore bodies migration was observed at the ore deposit scale with the use of the electron paramagnetic resonance spectroscopy. Crystalline radiation induced defects in clay minerals that were in close contact with uranium showed records of the past migration.

Cette thèse tente d’analyser comment les œuvres de Violette Leduc ont remis en cause, de façon avant-gardiste, les normes de sexe, de genre et de sexualité dans l’écriture de fiction. Différentes méthodes critiques sollicitées durant le travail permettent de mettre au jour le lien intime et corporel qu’entretient Violette Leduc avec ses œuvres. Ces méthodes permettent également d’entrevoir une poétique décalée, décentrée, qui déconstruit les genres littéraires et offre de nouveaux points de vue sur le monde. Il s’agit par conséquent de montrer dans ce travail que c’est à travers la poétique et non la rhétorique que l’auteure façonne, à la façon de l’artisan, une résistance à la norme. Trois concepts majeurs servent d’outils critiques à l’étude des textes : la performativité, la déconstruction et la limite toujours floue entre réalité et fiction. Ces outils, confrontés aux trois thèmes principaux de la corporéité, de la sexualité et de l’infra-ordinaire qui sont analysés de près dans ces recherches, remettent en question les désignations de « sexe », de « genre » et de « sexualité ». La position du lecteur se voit elle-même décentrée, afin qu’il puisse accéder aux « trésors à prendre » du texte. Il en résulte, conséquemment, la nécessité de reconsidérer les processus de la poétique et les impacts philosophiques, sociologiques et politiques de ces textes. / In this thesis we have tried to analyze how the works of Violette Leduc challenged, in an avant-garde manner, the norms of sex, gender and sexuality in fictional writing. Various critical methods have helped reveal the physical and intimate relationships between Violette Leduc and her own body of work. They have also helped foresee a shifting, off-centered poetics that deconstructs the literary genres and offers alternative views of the world. Hence we have aimed at displaying how the writer crafted, crafts(wo)manlike, a resistance to norms through poetics rather than rhetoric. Three main concepts have been used as critical tools for text analysis : performativity, deconstruction, and an ever-blurred limit between reality and fiction. Confronted to the three main themes of corporeity, sexuality and infra-ordinary – which are thoroughly examined in this work – these tools help questioning the very notions of sex, gender and sexuality. The reader himself is urged to shift off-center in order to get access to the texts’ « treasures to-be-taken ». It has appeared necessary, then, to reconsider the process of poetics and the philosophical, sociological and political impact of these texts.

Made available in DSpace on 2014-12-17T13:57:22Z (GMT). No. of bitstreams: 1 LarissaCMA.pdf: 3448770 bytes, checksum: 0288faa5858a50c76d71674fafbab097 (MD5) Previous issue date: 2005-11-28 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The present research if inserts in the subject of the habitation of social interest and its relation with the sanitation infra-structure questions (sewer, water, draining and garbage). Having as study universe the narrow river of the Forty , situated one in the city of Manaus, capital of Amazon, approaches questions that if present between the necessities of housing and the especificidades of the natural environment, whose characteristics evidence limits for the implantation of adequate habitations. The objective is to analyze the possibilities and the limits of the urban?stica regularization in the palafitas of the narrow rivers of Manaus, in view of the factors of habitability and ambient protection, expresses for the sanitation system - sanitary exhaustion, water supply, urban draining and garbage collection. The work approaches initially relative the conceptual aspects to the subject of social habitation in the country and its relation with the habitability factors, also focusing the question of the housing and the processes of urban informality in the city of Manaus. It deals with the process of constitution of the palafitas in the space of the city and its relation with the habitacionais politics, presenting the analysis of the implantation of the palafitas in relation to the sanitation infra-structure conditions (sewer, water, draining and garbage). As conclusion, it identifies to the possibilities and limits of urban?stica regularization of the palafitas implanted to the long one of the narrow river of the Forty , taking in consideration the systems of the sanitation infrastructure / A presente pesquisa se insere no tema da habita??o de interesse social e sua rela??o com as quest?es de infra-estrutura de saneamento (esgoto, ?gua, drenagem e lixo). Tendo como universo de estudo o Igarap? do Quarenta, situado na cidade de Manaus, capital do Amazonas, aborda quest?es que se apresentam entre as necessidades de moradia e as especificidades do meio f?sico natural, cujas caracter?sticas evidenciam limites para a implanta??o de habita??es adequadas. O objetivo ? analisar as possibilidades e os limites da regulariza??o urban?stica nas palafitas dos Igarap?s de Manaus, tendo em vista os fatores de habitabilidade e prote??o ambiental, expressos pelo sistema de saneamento esgotamento sanit?rio, abastecimento de ?gua, drenagem urbana e coleta de lixo. O trabalho aborda inicialmente os aspectos conceituais relativos ao tema de habita??o social no pa?s e sua rela??o com os fatores de habitabilidade, enfocando tamb?m a quest?o da moradia e os processos de informalidade urbana na cidade de Manaus. Trata do processo de constitui??o das palafitas no espa?o da cidade e sua rela??o com as pol?ticas habitacionais, apresentando a an?lise da implanta??o das palafitas em rela??o ?s condi??es de infra-estrutura de saneamento (esgoto, ?gua, drenagem e lixo). Como conclus?o, identifica as possibilidades e limites de regulariza??o urban?stica das palafitas implantadas ao longo do Igarap? do Quarenta, levando-se em considera??o os sistemas da infra-estrutura de saneamento

Made available in DSpace on 2014-12-17T14:19:53Z (GMT). No. of bitstreams: 1 IvaneideOSM.pdf: 374526 bytes, checksum: 37868f7c1128a8ac7de565c01fc9e2e6 (MD5) Previous issue date: 2006-07-01 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / Since minetics The economics and political promotion along the necessity of flexibility in states actions admited actors partipction and social controlo on process of construction in local development. The Programa Nacional de Fortalecimento ? Agricultura Familiar (PRONAF) by this framework consists suprass the specific points about contry world in order to embrace territorial dimension of development, focalizing actions that estimulate co-operative pratices among local agents. This work proposal intends to identify advances and regression of PRONAF Infra-estrutura (Framework) by one territorial pact organization considering its administration about mechamisms on advantage conmflicts between distinct actor and their ables to atimulates a construction of new relationships between governors and population. Undderstanding PRONAF action like a process that come from its instrumental proportion surpass looking for substantial elements constructionm on intervention of local development considering administration mechamisms in S?o Paulo do Potengi (RN) city-council-starting by Conselho Municipal de Desenvolvimento Rural as well changes of institutional arrangement with territ?rio da Borborema erection. Throngh documental studies, bibliography researches and interviews we indenttfy an articulante power of Territorial pact partnerships like one of these political process and its sector character as their limits / As pol?ticas de promo??o econ?mica, desde os anos 90, diante da necessidade de flexibiliza??o das a??es do Estado, adotaram a participa??o de atores e o controle social no processo de constru??o do desenvolvimento local. O PRONAF - Programa Nacional de Fortalecimento ? Agricultura Familiar, em sua modalidade de Infra-estrutura, consiste em uma das estrat?gias de interfer?ncia do Estado que se prop?e a ultrapassar as quest?es espec?ficas do mundo rural, no intuito de abranger a dimens?o territorial do desenvolvimento, enfocando a??es que estimulam a pr?tica cooperativa entre os agentes locais. A presente proposta de trabalho visa identificar os avan?os e retrocessos do PRONAF Infra-estrutura, na organiza??o de um pacto territorial, considerando seus mecanismos de administra??o de conflitos de interesses, entre os diferentes atores, e sua capacidade de estimular a constru??o de novas rela??es entre os governantes e governados. Compreendendo as a??es do PRONAF enquanto um processo, que parte da supera??o de suas medidas instrumentais em busca da constru??o de elementos mais substanciais de interven??o no desenvolvimento local, consideramos seus mecanismos de gest?o no munic?pio de S?o Paulo do Potengi RN, a partir da cria??o e implementa??o do Conselho Municipal de Desenvolvimento Rural, bem como das mudan?as no seu arranjo institucional, com a cria??o do Territ?rio da Borborema. Atrav?s de um estudo documental, pesquisa bibliogr?fica e realiza??o de entrevistas, identificamos a for?a articuladora das parcerias do pacto territorial como um dos avan?os desse processo pol?tico e o car?ter setorialista destas parcerias como um de seus limites