A presente dissertação tem por objetivo avaliar o método Bailey de seleção granulométrica de agregados para misturas asfálticas, desenvolvido no Departamento de Transportes de Illinois (IDOT) e que vem sendo usado desde o início da década de 80. Atualmente, pesquisas têm sido desenvolvidas com o intuito de aperfeiçoar a seleção granulométrica e, conseqüentemente, o desempenho de misturas asfálticas, incluindo estudos a respeito do método Bailey. Trata-se de um método de seleção granulométrica por volume que, através de um modo sistemático de ajuste da graduação dos agregados na preparação de uma mistura asfáltica, proporciona um forte esqueleto de agregado para resistir à deformação permanente. Resulta, também, em um adequado volume de vazios no agregado mineral, o que permite um maior teor de ligante e aumento da durabilidade da mistura. Os resultados obtidos neste trabalho mostram que as misturas Bailey, independentemente do tipo de agregado (basalto ou gabro), apresentam melhores resultados do que as misturas convencionais e termos de relação módulo de resiliência –resistência à tração. Os resultados do ensaio de fluência por compressão uniaxial estática indicam um melhor desempenho da mistura Bailey com basalto, embora a mistura convencional com gabro tenha apresentado um comportamento ligeiramente superior ao da mistura Bailey com gabro. / The main goal of the master thesis is the evaluation of the Bailey method of gradation selection of aggregates for hot mix asphalt (HMA). The method was developed at the Illinois Department of Transportation (IDOT) and it has been used since the early 1980s. Many researches are intending to improve the gradation selection and, consequently, the performance of HMA, including studies about the Bailey method. It is a method that uses a systematic way of selection and adjustment of the aggregate gradation to provide a strong aggregate skeleton. It also provides an adequate amount of voids in the mineral aggregate that result in higher binder content and improved durability. The results obtained in this work show that Bailey asphalt mixtures, for both aggregates considered, are better than conventional mixtures in terms of resilient modulus – tensile strength ratio. The results of static creep tests indicate that the Bailey mixture with basalt aggregates presents the best performance among the evaluated asphalt mixtures.

Everyone participates in escape. The drive to escape is something we are born with. It is a force that has ties to our curiosity, as well as our profound psychological restlessness, and can even be seen in our displeasure with boredom. This thesis introduces three forms of escape: pure diversions, games, and play. Focussing on a play-based escape, this thesis argues that this is the most important form of escape, because, through play, we promote our cognitive health and creativity. This thesis develops three lines of investigation: first an understanding of what play is; second, through understanding the conditions, context, and disposition necessary in order to engage in a play-based escape; and third, a study of play through the review of architectural case studies. It is through these investigations that this thesis will identify ten key strategies that architecturally accommodate play. These are: nature, complexity, dynamic, loose-parts theory, scale, the primitive, along a path, mystery, risk, and unmonitored feel. In order to develop a method of design which engenders an architectural atmosphere of play-based escape these characteristics are organized into three interconnected themes: a desire to explore the world around us, a desire for a dynamic stimulating environment, and the desire to be active and move our bodies. Finally, an architectural application of the design method concludes this thesis, with hopes to activate a play-based escape capable of awakening our creativity.

The main strategy of gender equality policies has since the 1990s been gender mainstreaming. Many government inquiries show how much the Swedish government, provincial governments and municipalities are working with gender mainstreaming. The purpose of this paper is to investigative how the municipalities within the county of Stockholm handle gender mainstreaming demands in relation to other demands that the municipalities face. This is in order to closer investigate the hidden factors that create barriers to gender mainstreaming efforts. Given the study's purpose and the formulation of research question, qualitative method is the most suitable method to fulfill the purpose. The theoretical starting points used in this study was organizational theories with discussion of concepts such as institutional isomorphism, rationalized myths, organizational hypocrisy, parallel processes, and especially the theory of loosely coupled systems. The conclusion of this study is that the municipalities within the county of Stockholm handle demands from the environment in different ways. Some municipalities loose couple their system as a temporary solution to deal with various demands placed on the municipality. The result is that there is a lack of coordination within municipalities and their various governments, which in turn results in many municipalities working with the gender issue in parallel processes, hence they lack an overview of the activities in the municipality. These factors are common barriers to gender mainstreaming efforts in the studied municipalities.

Η εργασία αυτή κινείται στα όρια της μορφολογίας με τη σύνταξη και έχει ως απώτερο στόχο να προσδιορίσει τη θέση της μορφολογίας στο πλαίσιο της γραμματικής. Οι δομές που μελετώνται, τα χαλαρά πολυλεκτικά σύνθετα (βλ. Ράλλη, 2005, προσεχώς), έχουν τη μορφή [Ε Ο] και [Ο Ο σε γενική]. Ανήκουν στην κατηγορία των συνθέτων και ορίζονται ως μορφολογικοί σχηματισμοί. Σε αντίθεση όμως με τα κλασικά σύνθετα, εμφανίζουν συντακτικά χαρακτηριστικά. Στο πλαίσιο επομένως ενός δομικού συνεχούς (Ράλλη 2005) οι σχηματισμοί αυτοί θα μπορούσαν να τοποθετηθούν εντός της μορφολογίας, στα όρια όμως με τη σύνταξη. Στην εργασία αυτή θα αναλυθούν οι ξεχωριστές ιδιότητες των χαλαρών πολυλεκτικών συνθέτων και θα διαφοροποιηθούν τόσο από τις ονοματικές φράσεις, όσο και από τις ενδιάμεσες δομές. Η διαφοροποίηση των τριών ειδών δεν αποκλείει όμως την κοινή αναπαράστασή τους, με τη μορφή σχεδίων παραγωγής λέξεων, σε ένα ιεραρχημένο δομησιολόγιο, έτσι όπως προτείνεται από το θεωρητικό πλαίσιο της Δομησιακής Γραμματικής (Construction Grammar, Booij 2005). Στο ίδιο δομησιολόγιο εντάσσονται και οι σχηματισμοί της μορφής [Ο Ο σε ονομαστική], για τους οποίους υποστηρίζεται ότι βρίσκονται σε διαδικασία γλωσσικής αλλαγής και συγκεκριμένα μορφολογοποίησης. / The main object of my assignment is the analysis of loose multi-word compounds in Greek. There are two possible structures of multi-word compounds in Greek. So they appear combinations of adjective and noun, for example «μαύρη λίστα» (black list) and combinations of a noun in nominative and an other one in genitive, for example «μηχανικός αυτοκινήτων» (engineer of cars). It is argued that multi-word compounds are object of morphological analysis because they share a lot of common characteristics with the classical one-word compounds. I could mention their non compositional meaning. At the same time they share some syntactic features or properties. These compounds consist of two words like a syntactic construction. There is also agreement or inflection. So the object of this work is considered to be the interaction between morphology and syntax, because multi-word compounds in Greek are morphological constructions, in which syntax has some kind of authority. In this analysis are used some tests in order to distinguish similar formations, like noun phrases or compound-like phrases. Even though these kinds of structures do not belong in morphology, are represented in the same way in a hierarchical construction. The same fact occurs also for structures, which consist of two nouns both in nominative, for example «άνθρωπος αράχνη» (man spider). This kind of structure is considered to be under morphologization.

Everyone participates in escape. The drive to escape is something we are born with. It is a force that has ties to our curiosity, as well as our profound psychological restlessness, and can even be seen in our displeasure with boredom. This thesis introduces three forms of escape: pure diversions, games, and play. Focussing on a play-based escape, this thesis argues that this is the most important form of escape, because, through play, we promote our cognitive health and creativity. This thesis develops three lines of investigation: first an understanding of what play is; second, through understanding the conditions, context, and disposition necessary in order to engage in a play-based escape; and third, a study of play through the review of architectural case studies. It is through these investigations that this thesis will identify ten key strategies that architecturally accommodate play. These are: nature, complexity, dynamic, loose-parts theory, scale, the primitive, along a path, mystery, risk, and unmonitored feel. In order to develop a method of design which engenders an architectural atmosphere of play-based escape these characteristics are organized into three interconnected themes: a desire to explore the world around us, a desire for a dynamic stimulating environment, and the desire to be active and move our bodies. Finally, an architectural application of the design method concludes this thesis, with hopes to activate a play-based escape capable of awakening our creativity.

I detta examensarbete har en geoteknisk utredning utförts för att bedöma ifall grundläggning aven bro över Fyrisån i Uppsala kan utföras på enklaste sätt, genom plattgrundläggning. Arbetethar grundats på att undersöka hur grundläggningen styrs av den postglaciala lerans tekniskaegenskaper. Problemformuleringen har varit, att undersöka hur den geotekniska projekteringenav bron, dels skulle kunna genomföras, dels ska genomföras utifrån beaktande och värderingav tekniska och i viss mån ekonomiska aspekter. De frågeställningar som behandlas är: Vilkautmaningar finns det med att bygga bron på den aktuella platsen? Vilka svårigheter finns detmed att bygga bron enligt enklaste sätt, Vilka ytterligare grundläggningsmetoder kan användasför att grundlägga bron samt hur ska dessa tillämpas? Arbetet har utförts med en inledandelitteraturstudie via Malmö Universitetsbibliotek, sökmotorn Libsearch och SGI:s bibliotek. Enfallstudie har utförts av jordlagerförhållandena vid Fyrisån, där utvärderingen baseras påanalyser av data från tillgängliga fältundersökningar i området. Handberäkningar hargenomförts för att överslagsmässigt kontrollera de geotekniska förutsättningarna i brott- ochbruksgränstillståndet. Handberäkningarna har jämförts med datorberäkningar från Plaxis 2D.Teorin som ligger till grund för beräkningarna baseras på etablerade standarder somkontrolleras mot flertalet källor. Undersökningarna visar att djupet till berg är ca 55 m underbefintlig markyta. Jordlagerföljden består generellt av fyllning på siltig torrskorpelera påsulfidlera på lera/silt på friktionsjord. Utmaningen med grundläggningen av bron kansammanfattas till den potentiellt miljöfarliga sulfidhaltiga leran som leder till svårigheter ibruksgränstillståndet, eftersom den har en benägenhet att ge stora sättningar vid belastning,kombinerat med det stora djupet till berg.Handberäkningar visar att bron inte kan grundläggas på platta på mark eftersom jorden går ibrott när den belastas av fundamentet för odränerade förhållanden, dvs. korttidstillståndet. Ävenberäkningar med Plaxis 2D indikerar att jorden går i brott. Handberäkningar ochplaxisberäkningar har också genomförts för att undersöka de sättningar som kan utbildas vidgrundläggning på platta på mark. Det tillåtna värdet för sättningar är 0,050 m medanhandberäkningarna ger en sättning på 0,52 m och Plaxis 2D 0,41 m. För att bron ska kunnagrundläggas på den postglaciala leran används istället pålar med en geoteknisk bärförmåga på725 kN. Pålarnas knäcklast har beräknats till 5254 kN. Totalt krävs 18 pålar för att grundläggabrofundamentet. Pålning används då det råder osäkerhet hur användningen av övrigagrundläggningsmetoder interagerar med sulfidhaltig lera, bland annat hur reaktionen mellankalk/cement och sulfidjorden fungerar, om t ex kalk-cement-pelare skulle ha använts istället förpålar, samt resultaten av en eventuell försurning av omkringliggande miljö. Sulfidhaltig lerasänker pH-värdet i jord vid exponering för syre.Handberäkningarna och datorberäkningarna visar liknande resultat, vilket tyder på att deterhållna resultatet är rimligt. Förutsättningarna som används för beräkningarna är baserade påempiriska samband, som vid jämförelse med resultat från genomförda sonderingar visar på engod överensstämmelse. Avvikelser i sonderingarna bedöms vara ett resultat bl. a av deskalrester som finns i jorden, vilket beaktas vid värdering av resultatet. Resultatet från denutförda studien visar, att grundläggning av platta på mark inte är möjlig, främst på grund av destora sättningar som kan förväntas utbildas. Grundläggning med pålning väljs utifrånmiljömässiga och tekniska krav. / In this thesis, a geotechnical investigation has been performed to assess if the foundation of abridge over Fyrisån, Uppsala, can be founded by plate foundation. The work has been based oninvestigating how the postglacial clay affects the construction based on the current groundconditions. Questions being answered are: what challenges there are in building the bridge atthe current location, what difficulties there are in building the bridge according to conventionalmethods and what foundation methods can be used to construct the bridge and how these shouldbe applied. The work has been carried out through a literature study. A case study has beenperformed of the soil conditions in Fyrisån which shows that the soil consists in general offilling on silty dry clay crust on sulfide clay on clay/silt on friction soil. The depth to rock is 55meters.The main challenge with this specific soil are the large compression, which is a result of largedepth and the fact that the soil consists of sulfide clay. The calculations by hand correspond thecalculation done in Plaxis 2D where the results show that the soil breaks in the undrained stateand the compression is 0,41m, 0,52 m by hand, compared to the maximum requirement of 50mm. The choice of foundation is piling due to the uncertainty of reaction betweenlimestone/cement and sulfide and the risk of acidification.The condition on which the calculations are based on is compared to completed probes whichshows a good correspondence. Any abnormalities are concluded to be a result of the soil’scontent of residual of shell. In conclusion the study shows that the foundation cannot be donewith a plate foundation and the soil has to be reinforced due to the large compression of thesoil.

京都大学 / 0048 / 新制・課程博士 / 博士(工学) / 甲第21357号 / 工博第4516号 / 新制||工||1703(附属図書館) / 京都大学大学院工学研究科都市社会工学専攻 / (主査)教授 大津 宏康, 准教授 PIPATPONGSA Thirapong, 教授 三村 衛 / 学位規則第4条第1項該当 / Doctor of Philosophy (Engineering) / Kyoto University / DGAM

4AbstractA pre-filled syringe consists of a number of different components and materials e.g. glass, polymer and silicone oil, which will, in various degrees, interact with the pharmaceutical protein and excipients contained within. In addition to soluble protein loss due to adsorption to silicone droplets, silicone oil (SO) have also been reported to form complexes with pharmaceutical proteins that potentially provoke early and late-stage immune responses. The objective of this project was to investigate the impact of 10 different syringe barrel and plunger combination on the quality on pharmaceutical X and the performance of the syringe (syringeability). This is an explorative study and the purpose of this study was to investigate what options there were rather than to make firm recommendations. pH measurements indicated all chosen combinations were within acceptance criteria. Similarly, subvisible particle with reference standards and USP <788> tests indicated that all chosen combinations were within acceptance criteria. Analysis of visible particles without reference standards indicated that all combinations except 1B and 1C were within acceptance criteria. In terms of syringeability, functional testing revealed that combination 8A was a very poor choice and combination 1B a very good choice. In all of the tests, the currently used combination 1A was within the acceptance criteria. With respect to both the pharmaceutical quality and syringeability, it was considered to be equally preferred as many other combinations. Therefore, there is no real urgency to exchange the currently used syringe. Further investigation of plunger B, and possible other plunger combinations is recommended as they might play a bigger role than the syringe barrel with regard to the syringeability. Additionally, placebo suspension can only be used as a representative alternative for testing pH. / En förfylld spruta består av många olika komponenter och material så som glas, polymer, silikon olja, vilka, till olika grad, kommer reagera med proteiner och hjälpämnen i läkemedlet. Utöver förlust av protein (som följd av adsorption till silikon droppar), har det även rapporterats att silikon olja (SO) bildar komplex med proteinerna i läkemedlet vilka kan framkalla en immunologisk reaktion. Syftet med detta projekt var att undersöka effekten av 10 olika kombinationer av sprut-höljen samt kolvar på kvalitén på läkemedel X samt sprutans prestationsförmåga. Detta är en explorativ studie och syftet var att undersöka vilka alternativ som finns samt få en indikation för hur de uppför sig snarare än att ge tydliga rekommendationer. pH mätningar indikerade att alla valda kombinationer var inom acceptanskriterier. Liknande, både mätning av synliga och mikroskopiska partiklar med hjälp av referenslösningar samt metod USP 788 indikerade att alla valda kombinationer var inom acceptanskriterier. Mätning av synliga och mikroskopiska partiklar utan referenslösningar indikerade att alla kombinationer utom 1B och 1C var inom acceptanskriterier. Gällande sprutkombinationernas funktionalitet (prestationsförmåga) visade det sig att kombination 8A var ett dåligt val och kombination 1B ett attraktivt val. I alla tester, den nuvarande använda kombinationen (1A) var inom acceptanskriterier. Med avseende på både läkemedlets kvalité samt funktionalitet visade sig 1A vara ett likvärdigt alternativ till de andra kombinationerna. Detta innebär att det i dagsläget inte finns ett akut behov av att byta ut det nuvarande sprutkombinationen. Fortsatt utredning av kolv B, samt andra kolvar, är att rekommendera då de kan ha större påverkan funktionaliteten än höljet. Vidare kan placebolösning enbart användas som ett representativt alternativ för att testa pH.

Este trabalho apresenta um estudo sobre o comportamento de tubos metálicos enterrados, submetidos ao carregamento móvel de um veículo. Foram realizadas análises numéricas utilizando o método de elementos finitos para o cálculo da tensão vertical no solo, momento fletor, tensão normal e deformação diametral vertical do tubo. Foram analisados 630 modelos, obtidos da variação das características do solo (módulo de elasticidade) com o objetivo de representar diferentes níveis de compactação do solo, características do tubo (espessura da parede do tubo) e da altura da camada de recobrimento do solo. O programa utilizado nas análises numéricas foi o SIGMA/W do pacote Geostudio. Os resultados encontrados apontam que as maiores tensões no solo, momentos, tensões normais e deformações no tubo ocorrem devido ao carregamento móvel quando este se localiza exatamente acima do tubo. Observou-se que o aumento da espessura da camada de solo que recobre a tubulação causa uma diminuição de 15% a 55% das tensões verticais no solo, momentos fletores, tensões normais e deformações no tubo. Foram desenvolvidas equações para o cálculo das deformações para os casos estudados. Foi também desenvolvido um procedimento para a moldagem de corpos de prova de areia no estado fofo (índice de vazios máximo) para realização de ensaios triaxiais. / This paper presents a study on the behavior of buried metal pipes, subjected to the vehicle live load. Numerical analysis using the finite element method to calculate the vertical stress were made on the ground, bending moment, normal stress and diametral vertical pipe deformation. 630 models were analyzed, obtained from the variation of the soil characteristics (modulus) in order to represent different levels of soil compaction, the pipe characteristics (thickness of the pipe wall) and the height of the soil cover layer. The program used in numerical analysis was the SIGMA/W Geostudio package. The results show that the highest stresses on the ground moments, normal stresses and strains in the tube occur due to live loading when it is located just above the tube. It was observed that increasing the thickness of the layer of soil covering the pipe causes a decrease from 15% to 55% of the vertical tensions in the ground, bending moments, normal stress and strain on the pipe. Equations were developed to calculate the deformations in the cases studied. It has also developed a procedure for molding sand specimens into the soft state (maximum void ratio) to perform triaxial tests.

This study explores incidents in a spatial and temporal context to achieve suitable strategies for urban planning and policing in crime prevention/reduction. For this purpose, space and time related incidents are analyzed through new crime ecology theories within the designed loose-coupled GIS-based system at mezo-micro ecological levels in a case area within Ankara Metropolis, in 2000. Its main argument is that incidents display differences in the spatial and/or temporal distribution among planned, squatter, and in-transition settlements. In exploring distribution of incidents at global and local scales, it also searches the validity and critical adaptability of the new theories developed/practiced in North American and European countries. In line with new theories, incidents at global scale displayed clustering in space and time. Generally, incidents in aggregate, concentrated mostly in planned / less in in-transition / least in squatter areas / and particularly during spring-summer months. However, incidents against people and against property predominated respectively in squatter and planned areas, and between 18:00-00:00, and 00:00-08:00. As for local scale, incidents in aggregate, displayed spatial interaction (clustering), but no space-time interaction. Spatial distribution in time suggested that incidents persistently occur mainly in planned areas. v Incidents against property displayed highest level of spatial, and also temporal clustering at global scale / and particularly spatial clustering (particularly for commercial burglaries/thefts) and space-time clustering (for residential burglaries) at local scale. Complementarily, relatively homogenous global scale spatial distribution of incidents against people is accompanied by their non local scale spatial clustering or space-time clustering, whereby space-time dispersion was observed for simple batteries.