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Syftet med denna uppsats är att ta reda på hur fem olika personer med OCD upplever framställningen av OCD i komediserien Scrubs samt dramafilmen The Aviator. Vidare togs det reda på varför intervjupersonerna upplever dessa framställningar som de gör och på vilka sätt de kan identifiera sig med dem. Studiens teoretiska ramverk är representationsteori, kodning och avkodning samt självkategoriseringsteori. Uppsatsens material består av kvalitativa intervjuer med fem olika intervjupersoner som alla har diagnosen OCD. Inför besvarandet av intervjufrågorna har intervjupersonerna tittat på avsnitt från Scrubs samt på filmen The Aviator där karaktärer med OCD finns med. Resultatet visar att fyra av fem intervjupersoner kan identifiera sig med fysiska tvångshandlingar som karaktären med OCD i Scrubs utför. Framställningen av OCD i The Aviator kan samtliga fem intervjupersoner identifiera sig med där majoriteten av dem identifierar sig i känslostämningen i form av stress, frustration och ångest som huvudkaraktären med OCD bitvis uppvisar. Den första slutsatsen är att intervjupersonerna upplever en mer adekvat framställning av OCD i The Aviator än i Scrubs, då framställningen i The Aviator innefattar en betydligt större del av det psykiska och känslomässiga lidande som OCD innebär. Den andra slutsatsen är att intervjupersonernas inställning till hur OCD framställs i Scrubs och The Aviator är beroende av den utsträckning i vilken de kan identifiera sig med detta.

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Les Troubles Obsessionnels et Compulsifs (TOC) sont un trouble mental sévère et fréquemment résistant. La physiopathologie du trouble se caractérise par des anomalies au sein des boucle cortico-striato-thalamo-cortical entrainant une hyper-activité du cortex orbito-frontal, du cortex cingulaire antérieur, du putamen. Au cours des dernières années, des anomalies structurales et fonctionnelles du cervelet ont de plus été mise en évidence dans les TOC venant compléter le modèle existant.Nous avons mise au point un protocole de traitement par tDCS ciblant le cortex orbito-frontal gauche et le cervelet droit pour les TOC résistants. Dans une première étude, nous avons étudié la faisabilité de ce protocole de traitement dans une étude ouverte. Cette étude a mis en évidence une réduction significative des symptômes dans une population de patient à haut niveau de résistance. Dans une deuxième étude, nous avons évaluer l’effet de ce traitement dans un protocole randomisé, contrôlé et parallèle contre placebo. Cette étude n’a pas confirmé l’efficacité de ce protocole de traitement. Dans cette même population, nous avons au cours du protocole mesuré les paramètres d’excitabilité corticale au niveau du cortex moteur par stimulation magnétique transrânienne. Nous avons ainsi mis en évidence que la tDCS provoquait une augmentation significative des processus d’inhibition (Short Interval Cortical Inhibition : SICI ) et une diminution non significative des processus de facilitation (Intra Cortical Facilitation : ICF). L’étude des effets cliniques et électro-physiologiques de cette approche thérapeutique novatrice dans les TOC résistants n’a pas permis de confirmer son intérêt clinique malgré un impact de ce protocole sur les modifications de l’excitabilité corticale inhérentes aux troubles. Ces données ont été mise en relation avec la littérature afin de proposer des perspectives d’évolution dans l’utilisation de la tDCS dans les TOC résistants / Obsessive-compulsive disorder (OCD) is a severe mental illness. OCD symptoms are often resistant to available treatments. Neurobiological models of OCD are based on an imbalance between the direct (excitatory) and indirect (inhibitory) pathway within this cortico-striato-thalamo-cortical loops, which causes hyperactivation in the orbito-frontal cortex, the cingular anterior cortex, the putamen. More recently, the role of cerebellum in the OCD physiopathology has been brought to light by studies showing structural and functional abnormalities. We proposed to use tDCS as a therapeutic tool for resistant OCD by targeting the hyperactive left orbito-frontal cortex with cathodal tDCS (assumed to decrease cortical excitability) coupled with anodal cerebellar tDCS. In a first study, we studied the feasibility of this treatment protocol in an open-trial. This study found a significant reduction in symptoms in a population with a high level of resistance. In a second study, we evaluated the effect of this treatment in a randomized-controlled trial. This study did not confirm the effectiveness of this intervention. We have assessed motor cortex cortical excitability parameters by transcranial magnetic stimulation. We thus demonstrated that the tDCS caused a significant increase of inhibition processes (Short Interval Cortical Inhibition: SICI) and a nonsignificant decrease in the facilitation processes (Intra Cortical Facilitation (ICF)). In addition, clinical improvement assessed by Clinical Global Impression at the end of the follow-up period (3 months) was positively correlated with SICI at baseline.tDCS with the cathode placed over the left OFC combined with the anode placed over the right cerebellum decreased hyper-excitability in the motor cortex but was not significantly effective in SSRI- resistant OCD patients. These works were discussed in light of the available literature to create future prospect in the field of tDCS treatment for OCD resistant patients

Afin d’expliciter les modes d’influence intervenant dans les Dialogues de Platon, nous étudions de quelle manière se déploie la magie notamment de Socrate, qui est présenté comme un sorcier par plusieurs interlocuteurs. Une étude générale préliminaire sur la magie portant sur l’anthropologie, les rituels, pathologiques (troubles obsessionnels-compulsifs) ou culturels, et enfin la pensée magique nous fournit un cadre pour envisager comment se manifeste l’influence chez Platon. Différents facteurs influent sur les modes de pensée des individus souvent à leur insu : personnalité, habitudes, société, éthique, ignorance, etc.. La magie oratoire est pratiquée, depuis Gorgias, par divers experts du discours comme les orateurs ou les sophistes, ce qui révèle l’ambiguïté de la magie de Socrate, alors qu’il prétend éliminer le faux et les illusions. Dans le Phèdre, différents types de possession se produisent, certaines incontrôlées, d’autres contrôlées, impliquant un processus d’initiation. La magie de Socrate trouve encore à s’illustrer avec plusieurs cas d’envoûtement marquants, mais aussi un usage d’incantations notamment pour traiter la crainte de la mort. Dans le domaine politique, le législateur recourt aussi aux incantations pour plus d’efficacité, vu qu’elles agissent sur la forme des comportements, contribuent à souder les citoyens et participent au contrôle social. Une législation sur les crimes de magie est aussi édictée. / To explain the modes of influence operating in Plato’s Dialogues, we study how Socrates and others use their magic as several interlocutors have called Socrates a sorcerer. A framework is given to our research with a preliminary general study about magic covering anthropology, rituals – pathological (obsessive-compulsive disorders) or cultural – and magical thought. In Plato’s works, the way people think is influenced by many factors often unknowingly: personality, habits, society, ethics, ignorance, etc. Since it had been analyzed by Gorgias, speech experts, such as orators or sophists, have been using oratorical magic in their performances. And then the ambiguity of Socrates’ magic blatantly appears whereas he claims to refute falsehood and eliminate illusions. Different types of possession occur in Phaedrus, some uncontrolled, other controlled, entailing an initiation. Socrates carries out his magic in several striking cases of bewitchment and he also uses incantations in particular to sooth the fear of death. In the political field, the lawgiver finds an interest in using incantations for more effectiveness in his task since they can shape the forms of behaviors, create strong bond between citizens and contribute to social control. A law about crimes of magic is also designed.

Researchers vary on their definitions of paraphilia. A difference exists between an individual possessing a paraphilia versus an individual possessing a paraphilic disorder. Hanson (2010) proposed a dimensional model of sexual deviance that includes a measure of intensity. However, research on sexual intensity has been lacking. A majority of existing research focuses on the potential risk factors of possessing a paraphilia or paraphilic disorder (e.g., criminality). There is less focus on whom in the population has the potential to develop a paraphilia; or which factors predict paraphilic behavior. The Big Five personality factors (openness to experience, conscientiousness, extraversion, agreeableness, and neuroticism), obsessive-compulsive behavior, and sexual fantasy (exploratory, intimacy, impersonal, and sadomasochism) were used to predict paraphilic intensity using the Edwards Paraphilic Inventory (EPI). Surveys were placed on Amazon Mechanical Turk (n = 100), the Celebrity Feet in the Pose website (via https://celebrityfeetinthepose.com), and its social media (n = 163) to reach a total of 263 participants. Results indicated that obsessive-compulsive behavior, sadomasochism, and agreeableness significantly predicted the level of paraphilic intensity. Such findings support that paraphilic disorders are likely obsessive-compulsive in nature. Furthermore, agreeableness and paraphilic intensity were negatively correlated. This suggests that the lower the individual is in agreeableness, the higher the likelihood he or she falls on the paraphilic spectrum. Lastly, those who practice sadomasochistic roleplay in the bedroom are likely to report higher levels of paraphilic intensity. According to the United States sample, 1 out of every 10 participants reported some type of paraphilic activity. Individuals who participated in the survey from the website self-reported higher levels of paraphilic behavior than those who completed the survey from Amazon Mechanical Turk. In addition, these individuals are represented in more than one paraphilic category. It remains unclear how large of a role pleasure plays in an individual seeking therapeutic or pharmacological help with paraphilic disorders. Pedophilic disorder was not examined due to ethical concerns with the United States and other various countries. Future research should examine education level and sexual orientation as predictors of paraphilic intensity.

Obsessive-compulsive disorder (OCD) and the spectrum of associated conditions, affect 2-4% of the population worldwide. Although heritability studies in OCD have shown a 3 - 12 times increased risk for first degree relatives, the identification of the underlying risk-conferring genetic variation using classic genetic association studies has proven to be difficult. The possibility of a larger contribution of rare genetic variants to the risk of psychiatric disorder has been suggested by several successful studies. We expect that a spectrum of risk allele frequencies exists, which includes not only common variation but also a substantial amount of rare genetic variants that contribute to OCD. This thesis is aimed at identifying and functionally characterizing rare genetic variation in the OCD spectrum. Identified statistically significant variants were scrutinized for changes related to synaptic function using high content screening and subsequent functional analyses. Identifying the genetic profile of rare variants found in the OCD spectrum cohort combined with the functional impact that these variants have has provided insight into the etiology of the OCD spectrum. With these approaches a foundation can be laid for the development of a predictive model of the OCD spectrum.

Tvångssyndrom består av obsessioner och kompulsioner och drabbar cirka två procent av befolkningen. Efter avslutad behandling är det många patienter som återfaller. Syftet med föreliggande studie är att undersöka huruvida tilläggsbehandling administrerad sex månader efter initial internetadministrerad kognitiv beteendeterapi (KBT) minskar risken för återfall och ökar andelen patienter som uppnår remission, vilket inte tidigare prövats. 97 deltagare, som redan erhållit internetadministrerad KBT, randomiserades till att ingå i behandlingsgrupp eller kontrollgrupp. Tilläggsbehandlingen bestod av tre veckor internetadministrerad KBT med fokus på att fasa ut behandlarens funktion till deltagarens närmaste omgivning. Resultaten visade att deltagarna i behandlingsgruppen hade en signifikant minskad risk att återfalla jämfört med kontrollgruppen. En tendens till ökad andel deltagare i remission i behandlingsgruppen erhölls också. Slutsatsen är att internetadministrerad tilläggsbehandling vid tvångssyndrom är en meningsfull intervention med återfallsprevention som syfte. Framtida forskning bör göra åtskillnad mellan återfallsprevention och ytterligare minskad symtombörda som syfte med tilläggsbehandling.

Disinfectants in drinking water can interact with natural organic matter (NOM) to form disinfection by-products (DBPs). Halogenated furanones (including MX and MCA) are a group of emerging DBPs that can account for a significant amount of the total mutagenicity found in drinking water. Source water characteristics and NOM removal capabilities of coagulation can greatly influence the formation of DBPs. This project examines the effects of bench scale coagulation and chlorination tests on NOM removal, DBP formation, and genotoxicity. NOM was characterized using liquid chromatography-organic carbon detection (LC-OCD). Experiments with Ottawa River, Otonabee River, and Lake Simcoe waters show that DBPs decreased with increases in coagulant dosage, due to the removal of NOM during coagulation. DBP formation and speciation was then compared with NOM content to identify specific fractions that contribute to the formation of these DBPs. Genotoxicity was directly linked to MX presence in chlorinated waters.

The response inhibition ability is part of executive functions, which may be defined as a set of higher cognitive processes particularly located in the frontal-subcortical circuits. Since the main obsessive-compulsive disorder (OCD) symptoms seem to be relevant to the inability of inhibiting certain stimuli, it can be assumed that response inhibition in these patients will be disrupted. Studies related to this topic have brought inconsistent results. Our research dealing with OCD patients has focused on two dimensions of the response inhibition - the behavioral inhibition, which generally includes the behavior control (for instance impulse control), and the cognitive interference, which is considered to be the cognitive component of inhibition process and is mostly associated with the control of internal cognitive processes. The first part of our research included the verification of hypothesis, stating that the increased severity of obsession is associated with the degree of disrupted ability of cognitive interference, while the severity of compulsions correlates with the degree of disrupted performance in tests measuring behavioral inhibition. The second research objective was to clarify whether the inhibition response ability was different between patients when the predominance of symptoms was...