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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
501

Combinatorial Approaches to Study Protein Stability: Design and Application of Cell-Based Screens to Engineer Tumor Suppressor Proteins

Ramasubramanian, Brinda January 2011 (has links)
No description available.
502

Sleep Duration, Sedentary Behaviour, Physical Activity, Depression, and Other Mental Health Outcomes Among Children and Adolescents

Sampasa Kanyinga, Hugues 17 June 2021 (has links)
Mental health problems are the leading causes of disability in Canada. Nearly 70% of mental health problems have their onset during childhood or adolescence. Thus, identifying modifiable determinants of mental health problems in children and adolescents can inform future interventions intended to prevent them in this age group. Until recently, research has examined relationships of movement behaviours, including sleep, sedentary behaviour and physical activity mainly with physical health indicators (e.g., adiposity, cardiovascular disease risk factors, etc.). The few studies that have examined the relationships between movement behaviours and mental health indicators have considered the former individually and in isolation of each other, ignoring the intrinsic and empirical interactions between these behaviours. Adjusting for all these behaviours in a traditional regression model that assumes independence between variables has been shown to produce flawed and inconsistent findings. The purpose of this doctoral dissertation is to examine how the combinations of physical activity, sedentary behaviour, and sleep duration are associated with depression and other mental health outcomes in children and adolescents, through a series of five research studies (one systematic review, 3 cross-sectional studies, and one longitudinal study). Empirical studies used data from 3 large and diverse samples of children and adolescents from Canada and the United States. Conventional regression models and structural equation modelling, and novel analytical techniques, including compositional data analysis were used to analyze the data. The systematic review confirmed the paucity of existing research in this area and identified important research gaps to be filled. Collectively, the results from cross-sectional studies showed that meeting all three recommendations was associated with lower odds of depressive symptoms and other mental health outcomes. However, this association appeared to be mainly driven by meeting the sleep duration recommendation, and to a lesser extent the screen time + sleep duration recommendations. There was a dose-response gradient from meeting none of the recommendations up to meeting two recommendations. Results from the longitudinal study using compositional data analysis provided further evidence suggesting that increasing sleep duration relative to the remaining behaviours (i.e. screen time and physical activity) was associated with lower depressive symptoms among all age/sex subgroups. Results further indicated that predicted changes in depressive symptoms were strongest and most beneficial when removing screen time while adding sleep duration. Finally, results from both cross-sectional and longitudinal analyses suggest that age and sex moderate the association between movement behaviour recommendations (individual or combined) and mental health indicators, depending on the type of movement behaviour and the type of mental health indicators. The findings from this body of work have shed new light on the association between movement behaviours and mental health indicators in children and adolescents by demonstrating that meeting all three movement behaviour recommendations is associated with better mental health, and that sleep duration and screen time were more strongly associated with mental health compared with physical activity in our studies.
503

Skolungdomars socialamedievanor och dess betydelse för sömnen : En integrativ systematisk litteraturöversikt / School-adolescents media habits and the importance for sleep : An integrative systematic literature review

Möller, Anna, Karlsson, Jennifer January 2021 (has links)
Bakgrund: Användning av sociala medier är idag ett utbrett fenomen och har blivit en naturlig del i, framför allt, skolungdomars liv. Skolungdomar tillbringar mycket tid framför digitala medier för att vara online och en del av det sociala sammanhanget. Samtidigt pekar statistiken på en försämrad sömn hos skolungdomar. I skolan arbetar skolsköterskan hälsofrämjande och förebyggande för att eleverna ska ha hälsa och nå målen. Syftet var därför att undersöka vad skolungdomars sociala medievanor har för betydelse för sömnen. Metoden som användes för att besvara syftet var en integrativ litteraturöversikt med induktiv ansats. Datainsamlingen genomfördes i databaserna Cinahl och Pubmed. Resultatet består av tretton vetenskapliga artiklar. Vid analysarbetet kunde några teman och subteman urskiljas som beskrev sociala mediers påverkansfaktorer på sömnen. Dessa var förlorad nattro, en oro för utanförskap samt en upplevelse av distraktion. Skolungdomars strategier för att främja den goda sömnen visade sig vara reglerad tillgänglighet och att se fördelarna av sociala medier. Slutsats: Ett tydligt samband kan ses mellan användning av sociala medier och sömn. Skolungdomars användning av sociala medier påverkar sömnen främst negativt både utifrån fysiska och psykiska aspekter. Skolsköterskan behöver arbeta aktivt med denna problematik både på individ- och gruppnivå samt involvera vårdnadshavare i problematiken för att kunna bidra till att skolungdomar ska känna välbefinnande och nå skolans mål. / Background: The use of social media is today a widespread phenomen and has become a natural part of, above all, the lives of the adolescents. Adolescents spend a lot of time in front of digital media to be online and part of the social context. At the same time, the statistics point to a deterioration in sleep among adolescents. In school, the school nurse works with health promotion and prevention so that the students have health and achieve the goals. The purpose was therefore to investigate what school-adolescent’s social media habits mean for sleep. The method used to answer the purpose was an integrative literature review with an inductive approach. The data collection was carried out in the databases Cinahl och Pubmed. The result consists of thirteen scientific articles. In the analysis work, some themes and sub-themes could be distinguished that describe the influencing factors on sleep in social media. These were lost faith in the night, a worry about exclusion and an experience of distraction. School-adolescent strategies for promoting good sleep turned out to be regulated accessibility and seeing the benefits of social media. Conclusion: A clear connection can be seen between the use of social media and sleep. Adolescents use of social media has a negative effect on sleep, both in terms of both physical and mental aspects. The school nurse needs to work actively with this problem at both individual and group level involve guardians in the problem to be able to contribute to adolescents feeling well and achieving the school’s goals.
504

Att klippa inom ramarna av en split-screen : En analys av klippning i split-screen utifrån tre fall

Edlund, Filip January 2024 (has links)
Denna uppsats applicerar teorier om klippning på tre utvalda sekvenser med split-screen för att ta fram data om vilka av Walter Murchs kriterier för klippning oftast förekommer inom split-screen, samt vilka av Karen Pearlmans tre typer av rytm som är mest applicerbara i rytmisk klippning. Under analysen granskas även användningen av dessa kriterier och rytm för att kunna dra generella slutsatser om hur klippningen påverkar scenerna, men även hur den samverkar tillsammans med split-screen. Resultatet visar att rytm är genomgående det mest förekommande elementet inom klippningen och i samverkan med split-screenen fördjupar klipparen publiken i filmens värld. Genom kreativa stilval som inte hade varit möjliga utan flera samtidiga bilder gestaltas filmens kärna via klippningen tillsammans med split-screenen. Framtiden av split-screen är fylld av potential, både i forskning och funktion inom filmmediet. Denna uppsats menar att belysa detta underutnyttjade stilgrepp och vill inspirera filmklippare framöver.
505

Development of genome editing technology of mitochondrial DNA in Saccharomyces cerevisiae / 出芽酵母ミトコンドリアDNA編集技術の開発

Amai, Takamitsu 23 March 2021 (has links)
京都大学 / 新制・課程博士 / 博士(農学) / 甲第23246号 / 農博第2453号 / 新制||農||1084(附属図書館) / 学位論文||R3||N5336(農学部図書室) / 京都大学大学院農学研究科応用生命科学専攻 / (主査)教授 植田 充美, 教授 白井 理, 教授 栗原 達夫 / 学位規則第4条第1項該当 / Doctor of Agricultural Science / Kyoto University / DGAM
506

Elecronic Wallet - Utveckling av en digital plånbok sett ur ett användarperspektiv

Isaksson, Markus, Johnsson, Magnus January 2008 (has links)
This essay is a product of our examination work on candidate level in Interaction Design. The aim in this project was to design a digital wallet integrated into a cellular phone and make it as an electronic payment tool. In our project the goal has been to create a digital wallet not just for payment, but also develop it into a complete digital wallet, replacing visa, membership card, student cards, id card and receipt. Our ambition is to take care of current qualities of today's wallet and improve where it is possible so that can be replaceable with the digital wallet.
507

Investigating How HTML5 Improves Accessibility

Mirzaee Naeeni, Fatemeh January 2016 (has links)
Nowadays, a lot of activities such as social communications, educational courses, banking processes, different types of entertainment, online registrations and many more are done through Internet websites. Millions of users use these websites to maintain their daily needs. The challenge in front is that these websites are getting more and more complex, and the need to have well-designed websites becomes more important and at the same time more difficult. Knowledge of usability and accessibility according to the user needs can help designing more convenient while competent websites. It is essential to know that users with different levels of ability may visit a website. They should be able to easily interact with the website based on their abilities, likes and dislikes. Users usually leave the website early if they find it difficult to handle. They may look after easier and more practical solutions to do what they need to do. So it is somehow important to design websites by considering all levels of abilities and disabilities. Therefore, there are standards that must be followed by designers. Basically, usability experts define standards for making a website operational for a vast range of users by reducing the sources of complexity which potentially lead to a problem. Standards set by experts for accessibility aspects mainly focus on making a website more approachable to a bigger portion of users including users with disabilities. This thesis investigates the role of HTML5 markup language in improving the accessibility of the websites. To achieve that, the main factors of accessibility in designing websites are considered and based on that the evaluation has been performed. To gain more applicable results, this thesis concentrates on screen readers as a kind of assistive technologies. The results illustrate that HTML5 markup language can improve the accessibility of a website design. Currently, there are still some difficulties to overcome, for example, browsers lack support for HTML5 and the screen readers are not as effective as they are needed to be. This probably means that we still need more research to find optimal ways of constructing websites with a perfect accessibility and usability for screen readers. / Numera finns en hel del aktiviteter såsom social kommunikation, utbildningar, bankprocesser, olika typer av underhållning, online registreringar och många fler som sker genom webbplatser på Internet. Miljontals användare använder dessa webbplatser för sina dagliga behov. Utmaningen är att dessa webbplatser blir mer och mer komplexa, och behovet av att ha väl utformade webbplatser blir både viktigare och samtidigt svårare. Kunskap om användbarhet och tillgänglighet enligt användarnas behov kan hjälpa till att designa webbplatser som samtidigt är både bekväma och kompetenta. Det är viktigt att användare med olika förmågor kan besöka en webbplats. De bör enkelt kunna interagera med webbplatsen med utgångspunkt från sina förmågor och preferenser. Användare lämnar vanligtvis webbplatsen tidigt om de har svårt att hantera den. De kan se sig om efter enklare och mer praktiska lösningar för att göra vad de behöver göra. Så det är någorlunda viktigt att utforma webbsidor genom att beakta alla nivåer av förmågor och handikapp. Därför finns det normer som måste följas av designers. Användbarhetsexperter definierar standarder för att göra en webbplats nyttig för ett stort antal användare genom att minska orsaker till komplexitet som potentiellt leder till problem. Normer som fastställts av experter på tillgänglighetsaspekter fokuserar huvudsakligen på att göra en webbplats mer tillgänglig för en större del av användarna, inklusive användare med funktionshinder. Denna rapport undersöker betydelsen av HTML5 med avseende på att förbättra tillgängligheten av webbplatser. För att uppnå detta, har de viktigaste faktorerna för tillgänglighet i utformning av webbsidor beaktats och grundat på det har en utvärdering genomförts. För att få mer applicerbara resultat, fokuserar denna rapport på skärmläsare som ett hjälpmedel. Resultaten visar att HTML5 kan förbättra tillgängligheten hos en webbdesign. För närvarande finns det fortfarande vissa svårigheter att övervinna, till exempel att webbläsare saknar stöd för HTML5 och att skärmläsare är inte lika effektiva som de behöver vara. Detta innebär förmodligen att vi fortfarande behöver mer forskning för att hitta optimala sätt att bygga webbplatser med perfekt tillgänglighet och användbarhet för skärmläsare.
508

Digital Signage - Infokiosk; Utforma för uppmärksamhet och interaktion

Czerwinski, Robert January 2012 (has links)
The purpose of this thesis is to investigate how Digital Signage systems such as public info kiosks can be designed to better fulfill its main use; to enlighten, encourage and influence the public with information. The challenges presented from earlier studies shows that the public interests and goals, together with proper and relevant content displayed in info kiosks have impact on the attention the public have towards public displays. Qualitative methods such as interviews, usability testing and observations were conducted to further examine how a public info kiosk can be designed to draw attention and grow interest amongst students at K3, Malmo University. Usability testing were used on the digital prototypes that were developed to ensure that the gestural user interface meet the requirements of a proper interaction from the users. Important insights were made concerning; the attention and interest to relevant content, the aspects of the gestural user interface along with the placement of the info kiosk in terms of context. These key factors need to be properly investigated and developed to ensure a better deployment of a public info kiosk. It is suggested that using the principles of interaction design by doing research and studies of public interest and needs, and optimizing it by taking the specific context of place and time in account when a designing content. The results from this thesis suggests that an installation of a public info kiosk will successfully earn the attention and interest from the public if the content is relevant and interesting to the specific public. It is also important that the systems perform well in terms of software and hardware to allow a fluid and intuitive interaction with the gestural user interface.
509

BIOLOGICAL EFFECTS OF HYDROXYLATED METABOLITES OF POLYCHLORINATED BIPHENYLS

Bhalla, Renu January 2011 (has links)
Polychlorinated biphenyls (PCBs) are widespread persistent organic pollutants. The metabolism of PCBs by various organisms involves many steps that can lead to the formation of a wide range of metabolites. These metabolites frequently exhibit a toxicity and biodegradability different than the parent compounds. There is currently little information available about the biological effects of PCB hydroxylated metabolites that can be generated by various organisms and potentially released into the environment. The objective of the present research is to compare the toxicity of selected PCB congeners and their corresponding mono-hydroxylated metabolites. To achieve this objective, the following specific aims were performed: (1) to determine the effect of selected PCBs and PCB hydroxylated metabolites on the growth rate of a model PCB-degrading bacterium, Burkholderia xenovorans LB 400, (2) to determine the microbial toxicity of PCBs and PCB metabolites using the bioluminescent assay Microtox®, and (3) to determine the estrogenicity of PCBs and PCB metabolites using the Yeast Estrogen Screen assay (YES). The effects of a range of PCBs (PCB-2, -3, -8, -9, -30, -35, -36, -39, -61, -68, and -79) and their mono-hydroxylated metabolites on the growth rate of the PCB degrader, Burkholderia xenovorans LB400, were recorded. The results showed that the parent PCBs (50 mg L-1) did not affect the growth rate of LB400 although their hydroxylated metabolites strongly inhibited microbial growth. Using Microtox® assay, Parent PCBs (50 mg L-1) did not exhibit observable toxicity, while their hydroxylated metabolites showed a high level of toxicity (EC50 ranges from 2 mg L-1 to 46 mg L-1). Results using the YES assay also showed that the estrogenicity of hydroxylated metabolites of PCBs (50 mg L-1) was higher than the parent PCBs. The results obtained from the present study show that mono-hydroxylated metabolites of PCBs are more toxic than the corresponding parent PCBs. Because hydroxylated PCB derivatives are produced by a range of organisms and potentially released into the environment, this work raises new concerns associated with the environmental fate of PCBs. / Civil Engineering
510

A Layered Whole

Sturniolo, Rebecca Lynn 28 August 2019 (has links)
a series of sectional graphics are created to represent the architectural whole. this thesis is about how a three dimensional architecture is seen and perceived through use of two dimensional graphics. it is about understanding a finished work [the whole] by viewing its individual sectional layers [the parts]. a whole does not exist without its parts, just as architecture would not exist without section. in this case, the section is raised above all other things in order to see the potential of the whole. / Master of Architecture

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