Submitted by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2014-12-18T11:57:11Z No. of bitstreams: 2 camila_danielle_cunha_neves.pdf: 1114741 bytes, checksum: d50be0f18b6b46636a9e4cf8ef159a66 (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2014-12-18T12:22:44Z (GMT) No. of bitstreams: 2 camila_danielle_cunha_neves.pdf: 1114741 bytes, checksum: d50be0f18b6b46636a9e4cf8ef159a66 (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2014-12-18T12:22:41Z (GMT) No. of bitstreams: 2 camila_danielle_cunha_neves.pdf: 1114741 bytes, checksum: d50be0f18b6b46636a9e4cf8ef159a66 (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2014-12-18T12:23:34Z (GMT) No. of bitstreams: 2 camila_danielle_cunha_neves.pdf: 1114741 bytes, checksum: d50be0f18b6b46636a9e4cf8ef159a66 (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) / Made available in DSpace on 2014-12-18T12:23:37Z (GMT). No. of bitstreams: 2 camila_danielle_cunha_neves.pdf: 1114741 bytes, checksum: d50be0f18b6b46636a9e4cf8ef159a66 (MD5) license_rdf: 22974 bytes, checksum: 99c771d9f0b9c46790009b9874d49253 (MD5) Previous issue date: 2014 / O efeito do consumo cr?nico do cigarro no perfil inflamat?rio, estresse oxidativo e desempenho f?sico t?m sido investigado em fumantes assintom?ticos, contudo, estes estudos na sua maioria ainda s?o poucos e divergentes. Sendo assim, o objetivo deste estudo foi avaliar o efeito cr?nico do tabagismo no perfil inflamat?rio, estresse oxidativo, fun??o muscular esquel?tica perif?rica e aptid?o cardiorrespirat?ria de homens adultos assintom?ticos. Os sujeitos do estudo foram divididos igualmente entre o grupo fumante (GF, n= 20) e grupo controle (GC, n= 20), composto por sujeitos n?o fumantes. A fun??o pulmonar de todos participantes foi avaliada pela espirometria. O perfil inflamat?rio foi avaliado pela mensura??o das concentra??es plasm?ticas das citocinas IL-6, TNF-?, IL-10 e pelos receptores sol?veis de TNF-? (sTNFR1 e sTNFR2). O estresse oxidativo foi avaliado pela mensura??o das concentra??es plasm?ticas das subst?ncias reativas ao ?cido tiobarbit?rico (TBARS), da atividade das enzimas antioxidantes super?xido dismutase (SOD) e catalase de eritr?citos e pela capacidade antioxidante total do plasma. A fun??o muscular esquel?tica perif?rica foi avaliada por meio das medidas de pico de torque dos m?sculos extensores e flexores de joelho e da resist?ncia e fadiga muscular dos m?sculos extensores de joelho; e a aptid?o cardiorrespirat?ria foi avaliada atrav?s da mensura??o do consumo pico de oxig?nio (VO2pico), frequ?ncia card?aca m?xima (FCmax) e dist?ncia caminhada em um teste m?ximo de caminhada/corrida. Sujeitos do GF apresentaram aumentos significativos das concentra??es plasm?ticas de TBARS e do receptor sol?vel sTNFR1 e diminui??es significativas da atividade da enzima catalase em lisado eritrocit?rio, comparados ao GC. Al?m disso, sujeitos do GF exibiram menor resist?ncia muscular dos m?sculos extensores de joelho como determinado pelas medidas de trabalho, com inalterado ?ndice de fadiga dos m?sculos extensores de joelho e pico de torque dos m?sculos extensores e flexores de joelho. A aptid?o cardiorrespirat?ria foi similar entre os sujeitos do GF e do GC. Este estudo demonstrou que homens fumantes cr?nicos e assintom?ticos exibiram altera??es no perfil inflamat?rio, no estresse oxidativo e na fun??o muscular esquel?tica perif?rica, quando comparados a n?o fumantes. / The effect of chronic cigarette smoking on inflammatory profile, oxidative stress and physical performance has been investigated in asymptomatic smokers, however, these studies are few and divergent. Thus, the aim of this study was to evaluate the chronic effect of smoking on inflammatory profile, oxidative stress, peripheral skeletal muscle function and cardiorespiratory fitness in asymptomatic adult men. The subjects of the study were divided equally between the smoking group (SG, n = 20) and control group (CG, n = 20) composed of non-smoking subjects. The lung function of all participants was assessed by spirometry. The inflammatory response was assessed by measurement of plasma concentrations of IL- 6, TNF- ?, IL -10 and soluble receptors for TNF-? (sTNFR1 and sTNFR2). Oxidative stress was evaluated by measuring plasma concentrations of thiobarbituric acid reactive substances (TBARS), the activity of antioxidant enzymes superoxide dismutase (SOD) and catalase in erythrocytes and the total antioxidant capacity of plasma. The peripheral skeletal muscle function was assessed by measuring the peak torque of the extensor and flexor muscles of the knee; and resistance and muscle fatigue of the knee extensor muscles; and cardiorespiratory fitness was assessed by measurement of peak uptake oxygen (VO2peak), maximum heart rate (HRmax) and distance walked on a maximum test of the walk/run. SG subjects showed significant increases in plasma concentrations of TBARS and soluble receptors sTNFR1 and significant decreases in erythrocyte catalase enzyme activity, compared to the CG. In addition, SG subjects exhibited less muscle strength of knee extensors muscles as determined by measures of work and unchanged fatigue index of the knee extensors muscles and peak torque of knee extensors and flexors muscles. Cardiorespiratory fitness was similar between subjects SG and CG. This study demonstrated that male chronic smokers, healthy adult, exhibited changes in the inflammatory response, oxidative stress and peripheral skeletal muscle function, when compared to non-smokers. / Disserta??o (Mestrado) ? Programa Multic?ntrico de P?s-gradua??o em Ci?ncias Fisiol?gicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2014.

Submitted by PPG Medicina e Ci?ncias da Sa?de (medicina-pg@pucrs.br) on 2018-07-13T12:12:39Z No. of bitstreams: 1 JOSIEL_SCHILLING_POETA.pdf: 5065733 bytes, checksum: 08aa2054169f20b8e7aff32b78b58210 (MD5) / Approved for entry into archive by Sheila Dias (sheila.dias@pucrs.br) on 2018-07-18T14:22:38Z (GMT) No. of bitstreams: 1 JOSIEL_SCHILLING_POETA.pdf: 5065733 bytes, checksum: 08aa2054169f20b8e7aff32b78b58210 (MD5) / Made available in DSpace on 2018-07-18T14:30:34Z (GMT). No. of bitstreams: 1 JOSIEL_SCHILLING_POETA.pdf: 5065733 bytes, checksum: 08aa2054169f20b8e7aff32b78b58210 (MD5) Previous issue date: 2018-03-28 / Introduction: Lesions affecting the peripheral nerves are quite common and can cause devastating damage to their lives of individuals, leading to important functional changes such as pain, morbidity and disability as well as, affecting their psychological condition. When the VII pair of cranial nerve is affected, patients may develop Peripheral Facial Paralysis (PFP), which include aesthetic, functional and emotional damages, as well as pain and discomfort. Treatment for lesions involving the peripheral nerves still presents limitations, since post-surgical results remain uncertain and unsatisfactory, especially in cases where nerve damage causes loss of substance. The use of autologous nerve grafting remains the "gold standard" of treatment; although it does present some important disadvantages. Trying to overcome all the difficulties and limitations, regenerative medicine together with tissue engineering have united their efforts with the purpose of improving the surgical techniques in the repair of this type of injury. Thus, in this context, many researches are being carried out with the aim of developing bioabsorbable materials associated with neurotrophic factors that can be used by the tubulization technique in substitution of the "gold standard". Objective: To evaluate the regeneration of the facial nerve of wistar rats submitted to a total transection of the nerve with loss of substance through the use of the tubulization technique with a PLGA / PCL polymer and autologous adipose stem cells. Material and Methods: 72 wistar rats were randomly divided into 3 groups (A, B, C) and submitted to a surgical procedure of injury (total transection with loss of substance) in the mandibular branch of the facial nerve, forming a gap of 6 mm. Immediately after the injury, the surgical procedure of nerve repair was performed according to the group to which they belonged. The rats of group A (control) were treated through the autologous nerve graft, with suture in the stumps. Group B rats were treated by the tubulization technique using a PLGA / PCL absorbable polymer sutured between the stents. The rats of group C were also treated by the tubulization technique, with the same polymer, but containing a quantity of autologous adipose stem cells in their interior. After 30, 60 and 90 days, the animals were euthanized for histological analysis. Results: The presence of the PLGA / PCL polymer, used by the tubulization technique, appears to have stimulated the formation of fibrosis in all evaluated groups. In 30 days there was no difference in the regeneration of nerve fibers between the three methods used to treat the facial nerve lesion of the rats used in this experiment. The use of stem cells associated with the PLGA/PCL tube presented better results than the "gold standard" in only 60 days. At 90 days, the "gold standard" and the technique of tubulization, without the use of stem cells, had the same results in nerve regeneration, and still, they were superior in relation to tubulization with the use of stem cells. / Introdu??o: As les?es que acometem os nervos perif?ricos s?o bastante comuns e podem causar danos devastadores na vida das pessoas, provocando altera??es funcionais importantes como, por exemplo, dor, morbidade e incapacidade, al?m de afetar a sua condi??o psicol?gica. Quando o s?timo (VII) par de nervos cranianos ? afetado, os pacientes podem desenvolver quadros de Paralisia Facial Perif?rica (PFP), que incluem preju?zos est?ticos, funcionais e emocionais, al?m de dor e desconforto. O tratamento para as les?es que envolvem os nervos perif?ricos ainda apresenta limita??es, visto que os resultados p?s-cir?rgicos continuam incertos e insatisfat?rios, principalmente nos casos em que a les?o ao nervo provoca perda de subst?ncia. O uso do enxerto aut?logo de nervo continua sendo o ?padr?o ouro? de tratamento, embora apresente algumas desvantagens importantes. Tentando suprir todas as dificuldades e limita??es, a medicina regenerativa, juntamente com a engenharia tecidual, t?m unido seus esfor?os com a finalidade de melhorar as t?cnicas cir?rgicas no reparo desse tipo de les?o. Nesse contexto, muitas pesquisas est?o sendo realizadas com o intuito de desenvolver materiais bioabsorv?veis, associados a fatores neurotr?ficos, que possam ser utilizados pela t?cnica da tubuliza??o em substitui??o ao ?padr?o ouro?. Objetivo: Avaliar a regenera??o do nervo facial de ratos wistar submetidos a uma transec??o total com perda de subst?ncia atrav?s do emprego da t?cnica da tubuliza??o com um pol?mero de PLGA/PCL e c?lulas tronco adiposas aut?logas. Material e M?todos: 72 ratos wistar foram randomicamente divididos em tr?s grupos (A, B, C) e submetidos a um procedimento cir?rgico de les?o (transec??o total com perda de subst?ncia) no ramo mandibular do nervo facial, formando um ?gap? de 6mm. Imediatamente ap?s a les?o, foi realizado o procedimento cir?rgico de reparo do nervo de acordo com o grupo ao qual pertenciam. Os ratos do grupo A (controle) foram tratados atrav?s do enxerto aut?logo de nervo, com sutura nos cotos. Os ratos do grupo B foram tratados pela t?cnica da tubuliza??o utilizando um pol?mero absorv?vel de PLGA/PCL suturado entres os cotos. J? os ratos do grupo C tamb?m foram tratados pela t?cnica da tubuliza??o, com o mesmo pol?mero, por?m contendo uma quantidade de c?lulas-tronco adiposas aut?logas em seu interior. Ao fim de trinta, sessenta e noventa dias, os animais foram eutanasiados para an?lise histol?gica. Resultados: A presen?a do pol?mero de PLGA/PCL, usado pela t?cnica da tubuliza??o, parece ter estimulado a forma??o de fibrose em todos os tempos avaliados. Em trinta dias n?o ocorreu nenhuma diferen?a na regenera??o das fibras nervosas entre os tr?s m?todos utilizados para o tratamento da les?o no nervo facial das cobaias neste experimento. O uso de c?lulas tronco, associadas ao tubo de PLGA/PCL, apresentou melhores resultados em rela??o ao ?padr?o ouro? somente em sessenta dias. Aos noventa dias, o ?padr?o ouro? e a t?cnica da tubuliza??o, sem a utiliza??o das c?lulas-tronco, tiveram os mesmos resultados na regenera??o do nervo e, ainda, se mostraram superiores em rela??o ? tubuliza??o com o uso de c?lulas-tronco.

Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2018-08-22T18:29:16Z No. of bitstreams: 1 2017 - Patr?cia Matias de Oliveira.pdf: 4157901 bytes, checksum: c1f04c6aaf7e310880932fe569e4b6ff (MD5) / Made available in DSpace on 2018-08-22T18:29:16Z (GMT). No. of bitstreams: 1 2017 - Patr?cia Matias de Oliveira.pdf: 4157901 bytes, checksum: c1f04c6aaf7e310880932fe569e4b6ff (MD5) Previous issue date: 2017-05-04 / CAPES / This study aimed to analyze urban entrepreneurship in peripheral cities. We discuss the entrepreneurial practices of the cities that compose the "Western Border Metrpolitan" (Itagua?, Japeri, Paracambi, Queimados, and Serop?dica). These municipalities had their potential for increased industrial and logistical attractiveness due to the inauguration of the Metropolitan Arch and fiscal incentives policies. In this way, municipal governments have used strategic geographical position, empty land and other facilities, to attract new investors to this region. The results show recent transformations and constant efforts to ensure a promising "investment image" of the region. We observe that cities are committed to adopting the model of Urban Entrepreneurship, in the effort to become a commodity to be consumed, adopting strong rhetorical discourse of how indispensable it is for its growth and development. / Este trabalho teve como objetivo analisar o empreendedorismo urbano em cidades perif?ricas. Discutimos as pr?ticas empreendedoras das cidades que comp?em a ?Borda Oeste Metropolitana? (Itagua?, Japeri, Paracambi, Queimados, e Serop?dica). Esses munic?pios tiveram seu potencial de atratividade industrial e log?stico aumentado devido ? inaugura??o do Arco Metropolitano e pol?ticas de incentivos fiscais. Dessa forma, as prefeituras municipais t?m se utilizado da posi??o geogr?fica estrat?gica, terrenos vazios e outras facilidades, para atrair novos investidores para essa regi?o. Os resultados mostram transforma??es recentes e esfor?os constantes para garantir uma ?imagem? de regi?o promissora a investimentos. Observamos que as cidades se empenham em adotar o modelo de gest?o p?blica empreendedora, no esfor?o de transformar-se em mercadoria para ser consumida, adotando forte discurso ret?rico do qu?o isso ? indispens?vel para seu crescimento e desenvolvimento.

Made available in DSpace on 2014-12-17T15:51:30Z (GMT). No. of bitstreams: 1 FelicidadeJC_DISSERT.pdf: 1319475 bytes, checksum: 2ded949f816fffa65b74a382748d9b1d (MD5) Previous issue date: 2012-03-13 / The current debate on rural development focuses on the territorial approach, recognizing the multifunctional character of rural areas. Emphasize the use of endogenous forces, the need of implement policies which valorize local specificities, the participation of social actors in revitalization of rural areas. In this context tourism enters as a means to induce a new dynamic to rural areas, since the activity is regarded as a channel for the upgrading of the natural and cultural resources and the rural way of life. This study focuses on local-based tourism as a promoter of rural development, giving an analysis of the social reality and potential for this tourism in the district of Dondo. In it, is proposed to analyze the potential for development of local-based tourism in the district of Dondo, assessing the extent to which local reality enables the inclusion of the community in the management of local tourism resources. For this, was showed the inclusion of local-based tourism in the current context of rural development, was identified and organized systematically the factors that influence the implementation of local-based tourism in the study area and was verified as far as possible the study area corresponds to the constraints identified, showing how local-based tourism can best been encouraged. Was adopted a qualitative methodological approach to both the procedures and data processing, but also by critical approach, using bibliographical research, semi-structured interviews that fell on the group of public administrators who work in tourism and community leaders. The critical analysis was based on the principles of sustainability o Sachs particular ecological, social, cultural, economic, space, beyond the analysis of political and institutional aspects. The survey results show that the district of Dondo has a potential for implementing a model of tourism development on a local basis, since it is rich in natural and cultural research, benefits from good network accessibility in the context of the market in the region, the population live according to their habits and customs and value their identity. There is also a good cooperation between community members, although not in tourism, a fact which is observed through the lever of community participation in associations, cooperatives, working in areas such as agriculture, fishing, environment, civic education etc. It also has public funding sources to augment or stimulate local investment. Despite obstacles such as inexistence of policies and local plans for tourism development, lack of awareness of tourism, lack of basic infrastructure, as well as equipment and facilities to support tourism, the results shows that these problems can be solved through a public commitment from both government, and community through a joint planning and participation / O atual debate sobre desenvolvimento rural focaliza a abordagem territorial, reconhecendo o car?ter multifuncional do espa?o rural. Enfatiza o aproveitamento das for?as end?genas, a necessidade de implementa??o de pol?ticas que valorizem as especificidades locais, a participa??o dos atores sociais na dinamiza??o e revitaliza??o do espa?o rural. ? neste contexto que o turismo entra como um dos poss?veis meios para induzir uma nova din?mica no espa?o rural, visto que a atividade ? tida como um canal para a revaloriza??o dos recursos naturais e culturais, bem como do modo de vida rural. Este estudo trata do turismo de base local como indutor de desenvolvimento rural, traduzindo-se numa an?lise da realidade e das potencialidades no distrito de Dondo. Nele se prop?s analisar as potencialidades para a implanta??o do turismo de base local no Distrito de Dondo, avaliando at? que ponto a realidade local possibilita a inclus?o da comunidade na gest?o dos recursos tur?sticos locais. Para tal mostrou-se a inser??o do turismo de base local no atual contexto de desenvolvimento rural; identificou-se e organizou-se sistematicamente os fatores que condicionam a implementa??o do turismo de base comunit?ria na ?rea de estudo; e verificou-se at? que ponto a ?rea estudada corresponde aos condicionantes identificados, mostrando como o turismo de base local pode ser melhor incentivado. Adotou-se como recurso metodol?gico a abordagem qualitativa, tanto pelos procedimentos e tratamento de dados, como tamb?m, pela abordagem cr?tica, utilizou-se tamb?m, a pesquisa bibliogr?fica e documental, as entrevistas semi-estruturadas direcionadas ao grupo de gestores p?blicos que atuam em turismo e lideres comunit?rios. A an?lise critica foi feita com base nos princ?pios de sustentabilidade, nomeadamente sustentabilidade ambiental, social, cultural, econ?mica e espacial, para al?m da an?lise dos aspectos pol?tico-institucionais. Os resultados da pesquisa mostram que o distrito de Dondo apresenta um potencial para implementa??o de um modelo de desenvolvimento de turismo de base local, pois ele ? rico em recursos naturais e culturais, beneficia-se de uma boa rede de acessibilidade no contexto do mercado da regi?o, a popula??o vive segundo os seus h?bitos e costumes e valorizam a sua identidade. Constata-se tamb?m uma boa coopera??o entre os membros da comunidade, embora n?o seja em turismo, fato que se observa atrav?s do n?vel de participa??o da comunidade em associa??es, cooperativas e n?cleos atuando em ?reas como agricultura, pesca, extra??o de carv?o vegetal, ambiente, educa??o c?vica, etc. Possui tamb?m fontes de financiamento p?blico para incrementar ou estimular o investimento local. Apesar de obst?culos como inexist?ncia de pol?ticas e planos locais para o desenvolvimento do turismo, falta de consci?ncia em rela??o ao turismo, insufici?ncia em infra-estruturas b?sicas, bem como em equipamentos e meios de apoio ao turismo, denota-se que estes problemas podem ser solucionados por meio de um comprometimento tanto do setor p?blico, como da comunidade atrav?s de uma planifica??o conjunta e participativa

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-02-01T21:57:42Z No. of bitstreams: 1 RodrigoGadelhaVasconcelos_TESE.pdf: 1777603 bytes, checksum: 142978c0b438c9eba25a0468ff97275f (MD5) / Approved for entry into archive by Elisangela Moura (lilaalves@gmail.com) on 2016-03-07T23:32:33Z (GMT) No. of bitstreams: 1 RodrigoGadelhaVasconcelos_TESE.pdf: 1777603 bytes, checksum: 142978c0b438c9eba25a0468ff97275f (MD5) / Made available in DSpace on 2016-03-07T23:32:33Z (GMT). No. of bitstreams: 1 RodrigoGadelhaVasconcelos_TESE.pdf: 1777603 bytes, checksum: 142978c0b438c9eba25a0468ff97275f (MD5) Previous issue date: 2014-12-18 / A les?o perif?rica de c?lulas gigantes (LPCG) e a les?o central de c?lulas gigantes (LCCG) s?o les?es histologicamente semelhantes que acometem a regi?o de cabe?a e pesco?o. O estudo teve a finalidade de analisar a express?o imuno-histoqu?mica atrav?s dos marcadores GLUT-1, GLUT-3 e M-CSF em uma s?rie de casos de les?o perif?rica e central de c?lulas gigantes, na tentativa de estabelecer poss?veis associa??es e correla??es entre a express?o destas prote?nas nessas les?es, buscando uma melhor compreens?o do diferente comportamento biol?gico dessas entidades patol?gicas. A amostra foi constitu?da por 20 esp?cimes teciduais emblocados em parafina de LPCG, 20 de LCCG n?o agressivo e 20 de LCCG agressivo, oriundos do Servi?o de Anatomia Patol?gica da Disciplina de Patologia Oral do Departamento de Odontologia da UFRN. Em rela??o ao GLUT-1, verificou-se uma diferen?a estatisticamente significante (p< 0,05) na quantidade de c?lulas mononucleares imunomarcadas entre a les?o perif?rica (LP) e a les?o central n?o agressiva (LCNA) e entre a LP e a les?o central agressiva (LCA). Em rela??o ? intensidade da marca??o tamb?m foi verificado uma diferen?a estatisticamente significante tanto para as c?lulas mononucleares quanto para as c?lulas gigantes entre LP e LCNA e entre LP e LCA, nas c?lulas gigantes tamb?m ocorreu uma diferen?a estatisticamente significante entre a LCNA e a LCA. Em rela??o ao GLUT-3, foi encontrada uma diferen?a estatisticamente significante entre LP e LCA e entre LCNA e LCA na quantidade de c?lulas mononucleares imunomarcadas. No que concerne ? intensidade de marca??o para a referida prote?na foi verificado uma diferen?a estatisticamente significante nas c?lulas gigantes entre LP e LCA. Para o M-CSF foi observado apenas uma diferen?a estatisticamente significante na intensidade de marca??o nas c?lulas mononucleares entre LP e LCNA e entre LP e LCA. Com base nestes resultados, pode-se concluir a participa??o do GLUT-1, GLUT-3 e do M-CSF na patog?nese das les?es estudadas. Os transportadores de glicose estariam envolvidos no fornecimento de energia, para o metabolismo energ?tico das c?lulas e a prote?na osteoclastog?nica estaria envolvida no mecanismo de reabsor??o ?ssea encontrada nessas les?es. / The peripheral giant cell lesion ( PG CL ) and the central giant cell lesion ( CGC L) are lesions histologically similar affecting the head and neck region . The study aimed to analyze the immunohistochemical expression of markers GLUT - 1 , GLUT - 3 and M - CSF in a series of cases of PGCL and CGCL , in trying to understand the different biological behavior of these pathologies . The sample consisted of 20 tissue specimens of PGCL 20 central lesion of not aggressive giant cell ( CLNAGC) and 20 central lesi on of aggressive giant cell ( CLAGC), coming from the Pathology Unit of Oral Pathology of the Department of Dentistry of UFRN . W as performed the s emi - quantitative and qualitative analysis of immunohistochemical expression of the markers in giant cells and m ononuclear cells . In relation to the GLUT - 1, it was found a statistically significant difference (p < 0.05) in the number of mononuclear cells immunomarked between the PGCL and the CLNAGC and between the PGCL and CLAGC . Regarding the intensity of staining w as also observed a statistically significant difference both at the mononuclear cells as in giant cells between PL and CLNAGC and between PGCL and CLAGC , at the giant cells there was also a statistically significant difference between the CLNAGC and CLAGC . In relation to GLUT - 3 , was found a statistically significant difference between PGCL and CLAGC and between CLAGC and CLNAGC in amount of mononuclear cells immunomarked . Regarding the intensity of labeling for such protein was found a statistically signifi cant difference at the giant cells between PL and CLAGC . To the M - CSF was observed only a statistically significant difference in the intensity of labeling at the mononuclear cells between PGCL and CLNAGC and between PGCL and CLAGC . Based on these results, we can conclude the participation of GLUT - 1, GLUT - 3 and M - CSF in the pathogenesis of the lesions studied. The bigger immunostaining of these proteins in mononuclear cells show that these cells perform a higher metabolic activity and osteoclastogenic, espe cially in CLAGC . It was found that the mononuclear cells were more related to the pathogenesis of the studied lesions than properly the giant s cell s.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-04-16T00:18:43Z No. of bitstreams: 1 JoseLuizDeSouzaNeto_DISSERT.pdf: 1239058 bytes, checksum: 35fc47910b0c3b443e84790b17b965e6 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-04-22T20:27:25Z (GMT) No. of bitstreams: 1 JoseLuizDeSouzaNeto_DISSERT.pdf: 1239058 bytes, checksum: 35fc47910b0c3b443e84790b17b965e6 (MD5) / Made available in DSpace on 2016-04-22T20:27:25Z (GMT). No. of bitstreams: 1 JoseLuizDeSouzaNeto_DISSERT.pdf: 1239058 bytes, checksum: 35fc47910b0c3b443e84790b17b965e6 (MD5) Previous issue date: 2015-04-30 / OBJETIVO: Desenvolver e avaliar o emprego de um dispositivo ajust?vel ao corpo para treinamento de habilidade de acesso venoso perif?rico no membro superior, para estudantes de gradua??o. M?TODOS: O trabalho compreendeu duas fases: I) desenvolvimento do simulador inovador e II) ensaio controlado comparando o desempenho do dispositivo ajust?vel ao corpo em rela??o ao simulador comercial no treinamento da habilidade de pun??o venosa no membro superior. Alunos da gradua??o do curso de medicina da UFRN (n=56) participaram da fase de interven??o, que foi constitu?da de pr?-teste, aula te?rica sobre acessos venosos perif?ricos, randomiza??o em grupos conforme o simulador utilizado para treinamento (Grupo Simulador Comercial e Grupo Simulador Inovador), pun??o real interpares, p?s-teste e question?rios de satisfa??o. RESULTADOS: Os Grupos Simulador Comercial e Simulador Inovador n?o tiveram diferen?a estatisticamente significativa quanto ? idade, sexo, cor, resultados do Pr?-teste e P?s-teste, avalia??o atitudinal e desempenho na execu??o da pun??o real. Os alunos do Grupo Simulador Experimental tiveram melhor desempenho no preenchimento do prontu?rio simulado. Ao t?rmino da pesquisa, o ganho cognitivo (conhecimento) teve significativo incremento em ambos os grupos. O grau de realismo, na percep??o dos alunos, foi equivalente em ambos os grupos. O grau de valor para o ensino do simulador inovador foi conceituado como bom a ?timo em 85,7% dos alunos que o utilizaram. CONCLUS?ES: Diante dos resultados obtidos, o simulador inovador demonstrou-se como uma alternativa de baixo custo para o ensino da habilidade de pun??o venosa em membro superior, onde o desempenho cognitivo, procedimental e atitudinal dos alunos que o utilizaram foi equivalente ao dos que treinaram em simulador comercial. / OBJECTIVE: To dev elop and evaluate the use of a body adjustable device for training of peripheral venous catheterization for healthcare undergraduate students . METHODS: This study involved two phases: I) development of the innovative simulator and II) a controlled trial co mparing the performance of the body adjustable device in relation to the commercial simulator for the training of venipuncture skills. A total of 79 first - year medical students participated in the intervention phase, which consisted of pretest assessment, lecture on peripheral venous access, randomization into two groups according to the simulator used for training (Commercial Simulator and Experimental Simulator), real venipuncture procedure, post - test assessment and evaluation of satisfaction. RESULTS: Gr oups were homogeneous in age, sex, pre - test and post - test scores, attitudinal assessment and performance in performing the real venipuncture. Students from the Experimental Simulator group performed better on the filling of simulated records. At the end of the study, cognitive gain significantly increased in both groups. The degree of realism perceived by students was equivalent for two groups. A total of 85.7% of students rated the Experimental Simulator as good or excellent. CONCLUSIONS: Experimental simu lator proved to be a low cost alternative for the training of venipuncture skills in upper limb. The cognitive procedural and attitudinal performances of students who used the experimental simulator were similar to those observed in the group trained with commercial simulator.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-04-26T19:45:44Z No. of bitstreams: 1 AnaGabrielaCamaraBatistaDaSilva_DISSERT.pdf: 1290926 bytes, checksum: 8d945ae20b850326ca6c815c81b574a7 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-04-29T19:00:33Z (GMT) No. of bitstreams: 1 AnaGabrielaCamaraBatistaDaSilva_DISSERT.pdf: 1290926 bytes, checksum: 8d945ae20b850326ca6c815c81b574a7 (MD5) / Made available in DSpace on 2016-04-29T19:00:33Z (GMT). No. of bitstreams: 1 AnaGabrielaCamaraBatistaDaSilva_DISSERT.pdf: 1290926 bytes, checksum: 8d945ae20b850326ca6c815c81b574a7 (MD5) Previous issue date: 2015-02-27 / A doen?a arterial obstrutiva perif?rica (DAOP) ? uma patologia oclusiva cr?nica da circula??o arterial perif?rica causada principalmente por aterosclerose. Um dos m?todos cl?nicos propostos para avalia??o do endurance e fun??o muscular de membros inferiores ? o Heel Rise Test (HRT) ou teste de eleva??o do calcanhar, por?m sua capacidade de predizer a disfun??o causada pela DAOP e sua rela??o com a composi??o corporal n?o foram elucidados. O objetivo geral do trabalho foi avaliar o endurance da musculatura de membros inferiores, atrav?s do HRT, e a composi??o corporal em mulheres idosas com ?ndice tornozelo-braquial (ITB) compat?vel com a DAOP e mulheres com ITB Normal. Foram avaliadas 60 mulheres idosas, sendo 39 com ITB normal e 21 com ITB DAOP. A composi??o corporal foi quantificada atrav?s da bioimped?ncia el?trica multifrequencial segmentar direta. N?o foram observadas diferen?as marcantes de composi??o corporal entre grupos al?m de tend?ncia de menor valor de massa muscular em membros inferiores no grupo ITB DAOP. O n?mero de repeti??es no HRT apresentou correla??o com a composi??o corporal tanto de massa de gordura e suas porcentagens (Massa de gordura corporal r= -0,461, p<0,001; porcentagem de gordura corporal r= - 0,45, p<0,001; Porcentagem de gordura de tronco r= -0,584, p<0,0001; Massa de gordura de tronco r= -0,450, p<0,001), quanto de massa muscular em membros inferiores normalizada pelo peso (r= 0,434, p<0,001); contudo, n?o houve correla??o com o ITB que apenas correlacionou-se com a velocidade de realiza??o do teste (r= -0,300; p=0,019). Embora apresente correla??o com a composi??o corporal, sobretudo massa muscular de membros inferiores e seja ?til para avalia??o da endurance muscular de membros inferiores, padroniza??es dos par?metros do HRT s?o necess?rias para que o teste tenha sensibilidade no diagn?stico e determina??o da progress?o da DAOP em mulheres. / Peripheral Artery Disease (PAD) is a chronic atherosclerotic pathology caused by occlusion of peripheral arterial circulation. The standing Heel Rise Test (HRT) has been recommended as a relevant clinical instrument to evaluate endurance and muscular performance in the lower limbs; however, its capacity to predict disability resulted from PAD and its relation to body composition has not yet been elucidated. The aim of this study was to evaluate muscular endurance of the lower limbs using the Heel Rise Test, and to compare body composition through ankle-brachial index in elderly women with and without PAD. Sixty women were evaluated, where 39 presented normal ankle-brachial index and 21 with PAD. The body composition was mensured by segmental multi-frequency bioelectrical impedance. There were no significant differences in body composition between groups apart tendency to lower muscular mass in lower limbs on the group of ankle-brachial index with PAD. The number of repetitions on HRT showed correlation with body composition regarding body fat percentages (Fat mass r= -0,461, p<0,001; Percentage body fat r= -0,45, p<0,001; Percentage trunk mass r= -0,584, p<0,0001; Fat trunk mass r= -0,45, p<0,001) and muscular mass in lower limbs normalized by the weight; nevertheless, there was no correlation with ankle-brachial index, that was only associated with the velocity performed on the test (r= -0,3001, p=0,019). While HRT has correlation with body composition, particularly with lower limb muscular mass, and presents effectiveness in evaluating muscular endurance in lower limbs, standardization of the test parameters is necessary in order to have sensitivity in the diagnosis and determinations of PAD progression in women.

Made available in DSpace on 2014-12-17T15:16:16Z (GMT). No. of bitstreams: 1 AnaTSNS_DISSERT.pdf: 1742541 bytes, checksum: 876ff103e594fa7d61ebc99b28b10c2c (MD5) Previous issue date: 2012-03-23 / Diabetes Mellitus (DM) affected approximately 171 million people in the world in the year 2000 as described by the World Health Organization (WHO). Because DM is a multisystem disease it can cause several complications especially those related to the cardiovascular system. The Peripheral Arterial Disease (PAD) of the lower limbs and the Diabetic Distal Symmetric Polyneuropathy (DDSP) can affect the DM patient causing consequences as the diabetic foot and eventually amputations. The main objective of this study was to determine the prevalence of PAD and sensorial impairment in 73 type 2 DM (DM2) patients and also assess the impact of PAD on quality of life, level of physical activity and body composition. For clinical assessment it was used: the ankle-brachial index (ABI); quantitative sensorial test for tactile sensibility (ST), pain (SD), vibration (SV); Achilles tendon reflex (RA); quality of life questionnaire (SF-36); modified Baecke physical activity questionnaire and bioelectric impedance. Prevalence of PAD in the studied population was 13.7%. ABI was inversely correlated to age (p=0,03; rh?= -0,26), diabetes duration (p=0,02; rh?= -0,28) and blood pressure (p= 0,0007; rh?= -0,33). There were lower scores for physical health summary on the SF-36 in DM2 patients; however, the presence of PAD predominantly mild did not significantly impact quality of life, body composition or physical activity level assessed by questionnaire. Fourteen patients (19.2%) present bilateral and symmetrical alterations in two or more sensorial tests compatible to DPN diagnosis. Abnormalities in ST, SD and SV were present in 27.3%, 24.6% and 8.2%; respectively. There was association of results from ST abnormalities with RA and mainly with SD, suggesting the importance of 10g monofilament use in DM2 routine assessment. In conclusion, the prevalence of PAD in subclinical DM2 was slightly higher compared to the general population and in agreement to previously published data in DM patients. The PAD severity was predominantly mild and still without repercussion on quality of life and body composition. Our study demonstrated a significant prevalence of both PAD and DPN in DM2 without previous diagnosis of these complications and indicates the necessity of early preventive and therapeutic interventions for this population / O diabetes melito (DM) afetava aproximadamente 171 milh?es de pessoas no mundo no ano 2000 segundo dados da Organiza??o Mundial da Sa?de (OMS). Por ser considerada uma doen?a multissist?mica o DM ? capaz de causar complica??es diversas, principalmente ?quelas relacionadas ao sistema cardiovascular. A doen?a arterial obstrutiva perif?rica (DAOP) de membros inferiores (MMII) e a polineuropatia distal diab?tica (PNDD) podem acometer o paciente diab?tico causando consequ?ncias como o p? diab?tico e eventualmente amputa??es. O objetivo principal deste estudo foi determinar a preval?ncia de DAOP e altera??es de sensibilidade em 73 pacientes diab?ticos tipo 2 (DM2) e avaliar o impacto da DAOP na qualidade de vida, n?vel de atividade f?sica e composi??o corporal desses pacientes. Para as avalia??es cl?nicas foram utilizados: o ?ndice tornozelo-braquial (ITB); testes quantitativos de sensibilidade t?til (ST, monofilamento de 10g), dolorosa (SD), vibrat?ria (SV); reflexo aquileu (RA); question?rio de qualidade de vida SF-36; question?rio de atividade f?sica habitual de Baecke e bioimped?ncia el?trica. A preval?ncia de DAOP na popula??o estudada foi de 13,7%. O ITB correlacionou-se inversamente com a idade (p=0,03; rh?= -0,26), tempo de diagn?stico referido (p=0,02; rh?= -0,28) e press?o arterial (p= 0,0007; rh?= -0,33). Foram encontrados piores ?ndices no sum?rio de sa?de f?sica do question?rio SF-36 nos pacientes diab?ticos, no entanto, a presen?a de DAOP, de magnitude predominantemente leve, n?o ocasionou altera??es significativas na qualidade de vida, composi??o corporal ou grau de atividade f?sica avaliado por question?rio. Quatorze pacientes (19,2%) apresentaram altera??es sim?tricas e bilaterais em dois ou mais testes de sensibilidade, compat?veis com o diagn?stico de NDP. Altera??es na ST, SD e SV estavam presentes em 27,3%, 24,6% 8,2% dos pacientes; respectivamente. Houve associa??o estat?stica entre os resultados da ST com o RA e principalmente com SD, denotando a import?ncia e praticidade da utiliza??o do primeiro m?todo na avali??o de rotina no DM2. Em conclus?o, a preval?ncia de DAOP em pacientes DM2 subcl?nicos foi ligeiramente maior que a apresentada na popula??o geral e compat?vel com estudos anteriores em pacientes DM. O grau de DAOP foi predominantemente leve e ainda sem repercuss?es significativas sobre a qualidade de vida ou composi??o corporal. O presente estudo mostrou que existe preval?ncia relevante tanto de DAOP quanto de PNDD em pacientes DM2 sem diagnostico pr?vio dessas comorbidades, demonstrando a necessidade de interven??es preventivas e terap?uticas precoces para a aten??o desta popula??o

Made available in DSpace on 2014-12-17T14:20:14Z (GMT). No. of bitstreams: 1 MarlosAB.pdf: 4674251 bytes, checksum: 073f903ffab7ed7811ca858cd95a4022 (MD5) Previous issue date: 2009-06-08 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The study is about youthful subjectivities in quarters, of the West Zone of Natal-RN, marked for lacks and contingencies that constitute the everyday life of the social existence of its young inhabitants. For this purpose the researchers selected two youth groups: the Association of Youths Constructing Dreams (in the quarter of Felipe Camar?o) and Lelo Melodia Crew (Quarter of Guarapes). Both are articulated through the strategy of coalition in regional and national nets. The hypothesis is that inside the groups and nets new youthful citizens arises. That would be a change in the representation of poor youth: from 1980 s street children - young whose social stigma associated poverty and crime to late 1990 s kids of project (pointing their trajectory in social projects) or, in present days, called as young peripherals - for the enrollment in cultural movements, as the hip hop movement - These new young citizens are contributing to new social imagery significations on poor youths. The methodology encloses: a) focal group; b) participant research analyzing the making arts (ways to think, social daily practices, actions engaged in a diversity plans) of youth groups; c) life stories of some of the youngs produced in workshops; d) not structuralized interviews. d) several documents of the groups; e) local and national surveys. Results emphasize a feeling of opening to a project of autonomy in relation to a social system that leaves them in a situation of social precariousness. Conclusion remarks that such practices of the youthful groups through the art, leisure, sport and culture unfold politics effect so that can point innovative forms of politics participation on the part of this specific segment of poor youths of Brasilian country, although conflicts and paradoxes crosses individual citizens, youth groups and youth nets. / Trata-se de estudar as subjetividades juvenis em bairros, da Zona Oeste de Natal-RN, marcados por faltas e conting?ncias que constituem a cotidianidade da exist?ncia social de seus jovens moradores. Acompanham-se dois coletivos juvenis, a Associa??o de Juventudes Construindo Sonhos (no bairro de Felipe Camar?o) e a Posse Lelo Melodia (Bairro de Guarapes) que se articulam atrav?s da estrat?gia de coliga??o em redes regionais e nacionais. Aventa-se a hip?tese que se gestam no interior dos grupos e redes juvenis novos sujeitos juvenis que de modo diverso dos outrora meninos de rua jovens cujo estigma social associava pobreza a criminalidade identificavam-se doravante por sua trajet?ria em projetos sociais como jovens de projeto ou denominavam-se jovens perif?ricos pelo engajamento em movimentos culturais, como o movimento hip hop e a partir desses novos sujeitos jovens, novas significa??es sociais imagin?rias sobre juventudes. Atrav?s da an?lise das artes de fazer (maneiras de pensar, pr?ticas sociais cotidianas, a??es engajadas em planos diversos) e das narrativas de vida de alguns dos jovens, verifica-se um sentimento de abertura a um projeto de autonomiza??o em rela??o a um sistema que os encarceram numa situa??o de precariedade social. Conclui-se que tais pr?ticas dos coletivos juvenis atrav?s da arte, lazer, esporte e cultura desdobram efeitos pol?ticos que podem apontar formas inovadoras de participa??o pol?tica por parte desse segmento espec?fico das juventudes de nosso pa?s, n?o obstante as conflitualidades e impasses que atravessam sujeitos individuais, coletivos e redes juvenis.

Made available in DSpace on 2014-12-17T14:20:16Z (GMT). No. of bitstreams: 1 RitaCASA.pdf: 3976340 bytes, checksum: ffe0e0e585cb52f663585b3198f5b1c1 (MD5) Previous issue date: 2006-12-27 / This report has as its objective the setting up of a social cartography, mapping and characterizing non-governmental organizations working with adolescents and young people (OSC) in the western districts of the city of Natal. Characteristics such as the profile, themes and principal activities, how the organizations fit into the public sector and their participation in social networks are observed. Thus common differences and similarities which serve as a means of indentification, take as reference the symbolic cartography of Boaventura of Sousa Santos. Since there are relatively few studies relating to civil society of Rio Grande do Norte and in particular, Natal, the starting point was the setting up of a database allowing for a general overview. Hence a panorama of the organizations could be observed: where they are located, when they were formed how they operate and their relationships with other sectors (the state, the market and civil society) in addition to basic facts and location. The principal lines of enquiry were a) the OSC which operate with the public comprising adolescents and young people and b) the OSC operating or having branches in four suburbs on the periphery of the western administrative region of the city (Felipe Camar?o, Bom Pastor, Cidade Nova and Guararapes).The present report has identified the impacts of ongoing social transformation caused by the process of globalization ,by the various currently contested political projects which are as follows: the project of neoliberal globalized capitalism(hegemonic)and the project of social emancipation (contra-hegemonic),how these are seen from the local viewpoint and how they influence the profiles and operation of the cartographic organizations. The area of the OSC is a heterogenous one with political, cultural and ideological strains, characterized by its infiltration, its local/global and multicultural dimensions. As civil organizations are fundamental in the processes of transformation within society, and following the idea of social emancipation referred to by Boaventura Santos, the enquiry classified the organizations according to the afore-mentioned characteristics, establishing eight types of associations. These different types and their respective characteristics were analysed from a related perspective using the mechanisms of symbolic cartography: scale, projection and symbolisation. The theoretical references underpinning this research arise from the debate on civil society which becomes redefined as a result of the dispute involving the two afore-mentioned political projects. These demand the theoretical application of the comprehension of heterogeneity in its diversity and complexity together with the idea of social emancipation.The main authors consulted were Boaventura de Sousa Santos, Antonio Gramsci, through the texts translated by Marco Aurelio Nogueira; Carlos Nelson Coutinho and Alberto Rivera ,who supported the construction of the types of associations identified by the local reality.Finally this research enabled an understanding of the current form of social action happening in the Space of the Four Neighbourhoods (Espa?o dos 4 Bairros) and how the distinct profiles analysed together with the ares of operation of the organizations define their emancipatory potencials within the following two poles: regulation/adaptation and emancipation/transformation / Esta pesquisa tem como objetivo realizar uma cartografia social com vistas a mapear e caracterizar as organiza??es da sociedade civil (OSC) que atuam com adolescentes e jovens da Regi?o Oeste da cidade de Natal, observando-se suas caracter?sticas quanto: ao perfil, temas, atividades principais, formas de inser??o no espa?o p?blico e participa??o em redes sociais, buscando identificar as diferen?as e semelhan?as que as singularizam e identificam. Uma vez que existem poucos estudos sobre o universo da sociedade civil do Rio Grande do Norte e de Natal, o ponto de partida foi a constru??o de um banco de dados objetivando construir uma vis?o geral, panor?mica dessas organiza??es - onde est?o, quando foram criadas, o que fazem, como se relacionam com os demais segmentos (Estado, Mercado, Sociedade Civil) - al?m de dados b?sicos formais e de localiza??o. Os principais recortes adotados foram: a) as OSC que atuam com o p?blico adolescente e jovem; e b) as OSC que atuam ou t?m sede em quatro bairros perif?ricos da Regi?o Administrativa Oeste da cidade (Felipe Camar?o, Bom Pastor, Cidade Nova e Guarapes). O presente estudo identificou como os impactos das transforma??es sociais em curso, motivadas pelos processos da globaliza??o, se manifestam no espa?o local e influenciam nos perfis e atua??o das organiza??es cartografadas. O campo das OSC ? um campo heterog?neo, com marcas pol?ticas, culturais e ideol?gicas, caracterizado pela sua capilaridade, sua dimens?o local/global e multicultural. Sendo as OSC um sujeito social de import?ncia fundamental nos processos de transforma??o, e tendo a id?ia de Emancipa??o Social em Boaventura de Sousa Santos, como refer?ncia, a pesquisa realizou uma classifica??o das organiza??es conforme o conjunto de caracter?sticas, j? mencionadas, estabelecendo oito tipos de associativismo. Esses tipos, e suas respectivas caracter?sticas foram analisadas numa perspectiva relacional, a partir dos mecanismos da Cartografia Simb?lica: a escala, a proje??o e a simboliza??o. Os referenciais te?ricos, que deram luz a presente pesquisa, foram: o debate sobre Sociedade Civil e a id?ia de Emancipa??o Social que se redefinem em meio ? disputa entre dois projetos pol?ticos - o projeto do capitalismo neoliberal globalizado (hegem?nico) e o projeto da emancipa??o social (contra-hegem?nico) - e exigem um esfor?o te?rico de compreens?o de sua heterogeneidade, diversidade e complexidade. Os autores centrais foram Boaventura de Sousa Santos, Antonio Gramsci, atrav?s das leituras trazidas por Marco Aur?lio Nogueira, Carlos Nelson Coutinho, al?m de Alberto Rivera que ap?ia a constru??o dos tipos de associativismo identificados na realidade local. Finalmente, a pesquisa permitiu conhecer como se configura, no presente momento, o campo social da sociedade civil que atua no Espa?o dos 4 Bairros e como os distintos perfis analisados e as ?reas de atua??o das organiza??es definem os potenciais emancipat?rios das mesmas, fazendo com que estas se movimentem ou se situem entre dois p?los: o p?lo da regula??o/adapta??o e o p?lo da emancipa??o/transforma??o