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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
261

Risk Management / Risk Management

Černák, Peter January 2009 (has links)
The Master's Thesis deals with the topic of risk management in a non-financial company. The goal of this Thesis is to create a framework for review of risk management process and to practically apply it in a case study. Objectives of the theoretical parts are: stating the reasons for risk management in non-financial companies, addressing the main parts of risk management and providing guidance for review of risk management process. A special attention is paid to financial risks. The practical part applies the framework created in the theoretical part on a case study -- review/gap analysis of risk management process in a Czech non-financial companies operating in utilities. Risk management process in this company is described with a special attention to management of financial risk. Author's own remarks on the process and recommendations are stated in the practical part.
262

Řešení důsledků živelních událostí prostřednictvím produktů komerčního pojištění / Solution of consequences of natural disasters with the help of commercial insurance products

Vytasilová, Jitka January 2009 (has links)
This diploma thesis deals with the natural disasters, which struck the Czech Republic in the last decades, and with the analysis of the commercial insurance products covering the natural risks. The first part is dedicated to general characteristics of natural events, analysis of the natural disasters in the Czech Republic, and to characteristics of products, which offer protection from natural danger. The next part analyses the products of property insurance for Czech citizens by Czech Insurance Company and ČSOB insurance company. The conclusion of the thesis compares their products from the point of view of insurable risks and the height of yearly insurance premium.
263

Risker och riskhantering i svenska små företag

Viklander, Daniel, Örnstedt, Fredrik January 2019 (has links)
Risker och riskhantering är ett ämne som har fått en stor betydelse i dagens samhälle, inte minst som en följd av finanskrisen. Det finns ett flertal studier på området men dessvärre finns det idag betydligt färre studier om riskhantering som riktar in sig på småföretag, trots det faktum att cirka 96 procent av Sveriges 1,2 miljoner företag är just småföretag. Syftet med denna studie är att beskriva hur svenska småföretag hanterar risker samt att förklara samband mellan variabler som storlek, ålder, bransch och internationalisering.    För att göra detta har en kvantitativ metod tillämpats, med en deduktiv ansats. En enkätundersökning har formulerats och skickats ut till 867 småföretag i Sverige som valdes ut ur en databas (Retriever Business) med ett systematiskt urval. Enkäten bestod av 23 frågor och författarna av studien fick svar från 121 företag. Den data som samlades in bearbetades och analyserades i Microsoft Excel samt SPSS. De statistiska metoder som användes för att analysera data är deskriptiv statistisk samt ett binärt logistiskt regressionstest.   Studien finner signifikanta samband mellan importerande företag samt valutarisker, vilket stödjer resultat från tidigare genomförda studier på området. Studien fann inga signifikanta samband mellan importerande/exporterande företag och marknadsrisker, vilket går emot resultatet av tidigare genomförda studier. Dessutom fann studien inga signifikanta samband mellan marknadsrisker samt IT-risker och diverse oberoende variabler, vilket var några av studiens hypoteser.   Studiens resultat och slutsatser kan framförallt komma till användning för småföretag i riskbedömningar och liknande. Detta gäller framförallt för företag som handlar mycket internationellt. Även banker kan ha användning av resultatet, då bankerna brukar vara mycket intresserade av hur företagen hanterar risker, exempelvis då lån ska ges. Även försäkringsbolag skulle kunna ha användning av studien då de kan vara intresserade av att se hur risker hanteras och hur riskmedvetna deras företagskunder är. / Risks and risk management is a topic that has gained great importance today, not least because of the financial crisis. There are several studies on the field but unfortunately, there are far fewer studies on risk management that target smaller companies today, even though around 96 percent of Sweden's 1,2 million companies are in fact small companies. The purpose of this study is to describe how Swedish small companies deal with risks and to explain connections between variables such as size, age, line of business and internationalization.    To accomplish this, a quantitative method has been applied, with a deductive approach. A survey has been constructed and sent out to 867 small companies in Sweden whom were chosen out of a database (Retriever Business) with a systematic sampling. The survey consisted of 23 questions and the authors of this study received answers from 121 companies. The data that has been collected were processed and analysed in Microsoft Excel and SPSS. The statistically methods used are descriptive statistics and a binary logistics regressions test.    The results of this study are that statistically significant connections between importing companies and exchange risks, which provides support for what previous studies in the field have come up with. No significant correlations were found for importing/exporting companies and market risks, which is the contrariety of the results of previous studies in the field. Furthermore, no statistically significant correlations were found between market risks and IT-risks with various independent variables, which were some of the study’s hypothesis.   The results and conclusions of this study could be used especially by smaller companies in risk assessments and such. This applies above all to companies that trade much internationally. Also, banks could find the results useful, since banks usually are very interested in how companies handle risks, for instance when a loan is to be given. Insurance companies could also find this study useful, as they could be interested in seeing how risks are managed and how risk aware their clients are.
264

Avaliação da integridade de luvas cirúrgicas em um hospital oncológico do interior paulista / Evaluation of the integrity of surgical gloves in an oncological hospital in the state of São Paulo

Luize, Paula Batista 11 May 2018 (has links)
Introdução: a utilização de luvas cirúrgicas estéreis é uma estratégia fundamental para a prevenção de infecção do sítio cirúrgico e para a proteção da equipe cirúrgica. Entretanto é comum a ocorrência de perfurações de luvas durante os procedimentos cirúrgicos as quais, em sua maioria, não são percebidas pelos profissionais. Objetivos: testar a associação entre a ocorrência de perfuração de luvas cirúrgicas e o número de cirurgiões em campo, o tempo de duração da cirurgia, o tipo de cirurgia, o tipo de abordagem cirúrgica e a especialidade cirúrgica. Materiais e Métodos: trata-se de um estudo de corte transversal realizado num hospital especializado em oncologia do interior paulista. A população do estudo foi composta por 3.966 luvas utilizadas em 359 cirurgias realizadas no referido hospital, no período de 01 de janeiro a 28 de fevereiro de 2018. A avaliação da integridade das luvas cirúrgicas foi realizada por meio de análise visual e da insuflação de líquido, conforme a norma EN 455-1. Os dados foram analisados por meio de estatística descritiva e pela técnica de regressão logística multivariada, utilizando-se o programa estatístico IBM SPSS Statistics versão 21. Resultados: Das 359 cirurgias analisadas, 145 (40,4%) cirurgias apresentaram luvas perfuradas. Das 3.966 luvas coletadas, 254 (6,4%) apresentaram perfuração. Do total de perfurações identificadas, 163 (64,2%) ocorreram na mão esquerda, atingiram o dedo indicador 94 (37,0%). As varáveis associadas à perfuração de luvas identificadas no modelo final foram cirurgias com tempo de duração acima de 120 minutos (OR: 3,06; IC 95%: 1,52 - 6,14) e cirurgias realizadas pelas especialidades da Ortopedia (OR: 4,40; IC95%: 2,36 - 8,20), do Tórax (OR: 3,28; IC95%: 1,75 - 6,17), da Urologia (OR: 2,97; IC95%: 1,53 - 5,76) e do Digestivo Baixo (OR: 2,35; IC95%: 1,22 - 4,54). Ressalta-se que as cirurgias realizadas por vídeo se constituíram num fator de proteção (OR: 0,35; IC95%: 0,22 - 0,56). Conclusão: o presente estudo confirmou a associação entre a perfuração de luvas e tempo de duração da cirurgia acima de 120 minutos e especialidades cirúrgica, além disso, as cirurgias realizadas por vídeo se constituíram como um fator de proteção. Acredita-se que os resultados obtidos poderão subsidiar a proposição de medidas de prevenção e consequentemente contribuir para a segurança dos pacientes e dos profissionais da área da saúde / Introduction: the use of sterile surgical gloves is a fundamental strategy for the prevention of infection of the surgical site and for the protection of the surgical team. However, perforated gloves are common during surgical procedures which, for the most part, are not perceived by professionals. Objective: to test the association between the occurrence of surgical glove perforation and the number of surgeons in the surgery, the duration of the surgery, the type of surgery, the type of surgical approach and the surgical specialty. Materials and Methods: this is a crosssectional study conducted at a specialized hospital in oncology in the state of São Paulo. The study population consisted of 3.966 gloves used in 359 surgeries performed at the referred hospital, from January 1 to February 28, 2018. The evaluation of surgical glove integrity was performed through visual analysis and fluid insufflation, in accordance with EN 455-1. Data were analyzed using descriptive statistics and the multivariate logistic regression technique using the IBM SPSS Statistics version 21 statistical program. Results: of the 359 surgeries analyzed, 145 (40,4%) surgeries had perforated gloves. Of the 3.966 gloves collected, 254 (6,4%) presented perforation. Of the total number of perforations identified, 163 (64,2%) occurred in the left hand, reaching the index finger 94 (37,0%). The variables associated with the perforation of gloves identified in the final model were surgeries with duration time over 120 minutes (OR: 3,06; 95% CI: 1,52 - 6,14) and surgeries performed by Orthopedics specialties (OR: 4,40; 95% CI: 2,36 - 8,20), Thorax (OR: 3.28; 95% CI:1.75 - 6.17), Urology (OR: 2,97; 95% CI: 1,53 - 5,76) and the Low Digestive (OR: 2.35; 95% CI: 1,22 - 4,54). It should be emphasized that the surgeries performed by video were constituted as a protection factor (OR: 0,35; 95% CI: 0,22 - 0,56). Conclusion: the present study confirmed the association between the perforation of gloves and the duration of surgery over 120 minutes and surgical specialties, besides that the surgeries performed by video were constituted as a protection factor. It is believed that the results obtained may support the proposal of preventive measures and consequently contribute to the safety of patients and health professionals
265

Segurança hídrica e a gestão de risco da RMSP / Water Security and the risk management of RMSP

Delgado, Juliana Aparecida da Silva 25 September 2018 (has links)
A estiagem ocorrida no verão entre 2013 e 2014 prejudicou a recarga dos reservatórios do Sistema Cantareira e colocou em risco o abastecimento da Região Metropolitana de São Paulo (RMSP). Apesar de ser atribuída aos fatores climáticos, a (in)ação dos tomadores de decisão no âmbito da gestão de recursos hídricos pode ter contribuído para o agravamento do que ficou conhecido como a pior crise hídrica desde 1953. A condução do gerenciamento da crise foi marcada pela incapacidade das autoridades em fornecer uma resposta para a solução dos problemas decorrentes. Dessa forma, esta dissertação teve como objetivo realizar um levantamento histórico da gestão de recursos hídricos da RMSP, identificar e analisar os instrumentos para a segurança hídrica e gestão de risco nas políticas e o conjunto de políticas e estratégias adotadas para a RMSP para combater a crise hídrica como planos, programas e obras em andamento ou planejadas com foco no Plano de Contingência. A pesquisa foi realizada por meio de estudo de caso. Este trabalho considera que não foram adotadas medidas que visassem a gestão de risco, mas sim a gestão de crise, caracterizada pelas ações reativas dos tomadores de decisão. Tais ações foram controversas aos princípios de integração, participação e descentralização das políticas de recursos hídricos. Essa situação refletiu na elaboração tardia do Plano de Contingência, que ofereceu diretrizes vagas e pouco esclarecedoras. / The drought ocurred during the summer of 2013 and 2014 damaged the recharge of the reservoirs of Cantareira System and it put at risk the water supply of the Metropolitan Region of São Paulo (MRSP). Although attributed to climatic factors, the (in)action of the government decision-makers in relation to the management of water resources may have contributed to the aggravation of what was considered as the worst water crisis since 1953. The authorities\' inability to provide a response to the solution of the problems conducted the management of the crisis. Thus, this work aimed to carry out a historical survey of the water resources management of the MRSP, to identify and analyze the instruments for water security and risk management policies and the set of policies and strategies adopted for the MRSP to combat the crisis such as plans, programs and works in progress or planned focus on the Contingency Plan. This research was carried out through a case study. This work considers that the measures which were adopted did not aim the risk management, they just aimed the crisis management, characterized by the reactive actions of the government decision-makers. Those action were contradictory in relation to the principles of integration, participation and decentralization of water resources policies. That situation reflected in a late elaboration of the Contingency Plan which offered vague and unclear guidelines.
266

Comment mesurer l'influence de l'information préventive sur les risques majeurs ? : L'intérêt de la mise en situation sur maquette / How to assess preventive information on major risks? : The interest of role play on a 3D platform

Borelly, Audrey 27 May 2019 (has links)
Depuis 1987, l’information préventive sur les risques majeurs est un droit accordé aux populations. Elle est transmise sous diverses modalités : des documents règlementaires (DICRIM, brochure PPI etc.) et une variété de supports et formes d’expressions alternatives (pièces de théâtre, clips, expositions etc.). L’efficacité et l’impact de la première catégorie d’information préventive est déjà évaluée par des questionnaires réalisés auprès des populations. Cependant, ces évaluations ne permettent pas de vérifier si ces informations induisent effectivement des comportements adaptés en condition de stress que procure un évènement extrême. L’impact de la seconde catégorie d’information apparait comme très peu étudiée, alors qu’elle se caractérise par des méthodes et outils originaux, empruntés aux arts et à la pédagogie, et produisant une certaine participation des populations et l’activation du corps, des sens et des émotions. Or les sciences de la communication ont montré que la mobilisation des sens et des émotions favorise la mémorisation des messages.Devant ce constat, cette thèse propose d’évaluer l’influence des différentes formes d’information préventive sur les comportements en situation de crise fictive, par la création et l’expérimentation d’une nouvelle méthode inspirée des arts et des jeux de rôle. Ce faisant, l’étude compare d’une part cette nouvelle méthode à celle par questionnaire, et d’autre part les modalités d’informations réglementaires aux informations alternatives. En se focalisant sur les risques d’inondation, de séisme et d’émanation de gaz toxique, cette comparaison est mise en place sur trois terrains d’étude en Isère : Grenoble, Jarrie et Saint-Egrève. En mettant les enquêtés en situation sur une maquette, en les confrontant à des dilemmes que peut faire émerger l’urgence de la crise, la thèse met en exergue des réactions qui n’apparaissent pas dans les questionnaires : des réactions réflexes, contraires aux connaissances des enquêtés, des hésitations, etc. Les apports et limites des informations préventives sont alors précisées, selon les contextes et profils sociogéographiques des enquêtés. Les résultats montrent l’intérêt de multiplier les modalités d’informations et de les adapter sur des publics particuliers en favorisant l’échange et la contextualisation de la crise. / Since 1987, populations have been granted access to preventive information about major risks. It is passed down through a variety of methods, from regulatory documents (DICRIM, PPI brochure etc.) to original supports and alternative expression forms (plays, video clips, exhibitions etc.). Direct questionnaires to populations already assess the efficiency and impact of first category preventive information. However, these assessments do not check whether the information has actually induced adapted behaviors when confronted to stressful conditions, as is the case with extreme events. On the other hand, the impact of second category information appears under-studied, while it is characterized by original methods and tools. These methods, borrowed from arts and pedagogy, generate an interesting popular response, by activating emotions and resorting to sensory stimulation. As a matter of fact, communication science has shown that mobilizing sense and emotions helps with message memorization.In the face of these observations, this thesis proposes to assess how different ways to pass down preventive information influence behavior in a fictional crisis situation. To that end, a new method inspired from arts and role play has been created and experimented upon.Therefore, the study first compares this new method to the classic questionnaire method, and secondly, it opposes regulatory documents to alternative information. By focusing on floods, earthquakes and gas emanation risks, the comparison has been set up and studied on three different sites in Isère in France: Grenoble, Jarrie et Saint-Egrève. The respondents were presented a 3D model as the operating stage, and then confronted to typical dilemmas that can stem from emergency situations. Here, this thesis has highlighted reactions that surveys cannot reveal: reflex actions sometimes contradicting the respondents’ knowledge, hesitations, etc. Benefits and limits of preventive information are thereby more accurate, and depend on circumstances as well as on the respondents’ sociogeographic profiles. The results demonstrate how necessary it is to multiply and diversify the modes of information transmission, and to adapt them to specific audiences, through experience sharing and crisis contextualization.
267

An assessment of occupational health and safety in the informal car maintenance,welding and spraypainting industry in Mbabane.

Mamba, Richard Mfana 19 February 2007 (has links)
Student Number : 0215978H - MPh research report - School of Public Health - Faculty of Health Sciences / The study was conducted in the City of Mbabane and assessed Occupational Health and Safety in the informal car maintenance, welding and spray-painting industry. The objective of the study was to assess the risks workers are exposed to in the informal car maintenance, welding and spray-painting industry in Mbabane city in Swaziland. Data was collected by administration of a questionnaire to managers of the establishments and by personal observations of workers while on the job from walk through surveys that were conducted in the city. Seventy (70) workplaces were identified and sixty five (65) of them participated in the study, representing a response rate of 92.86%. There were twenty (20) workplaces doing car maintenance, twenty five (25) doing welding and twenty (20) doing spray painting. Fifty-three (53) The data was analysed using the EPI INFO software and results revealed that most workers in this sector were indeed at high risk of exposure to occupational health and safety problems. They worked under unfavourable conditions such as working in the open and subjected to adverse weather conditions, exposed to solvents, welding fumes and gases, strenuous work, improper postures, lifting heavy loads, exposed to spray painting aerosols and fumes and exposed to dust. The workers’ occupational health and safety was made worse by the fact that most of them did not have or use personal protective equipment. 90% of the workers were exposed to emissions while carrying out their jobs of spray painting and 10% of them were exposed to paint. All the workers that were doing spray painting were exposed to paint (95%) and solvents 5%). Although 75% of the workers, doing spray painting had some kind of personal protection provided however the usage rate was very low. In all the workplaces that were doing spray painting, there were no other existing control measures for protecting the workers from paint emissions 76% did not have any respiratory protection. However, only 33.3% of them were using the PPE provided and 66.7% were not using them. Therefore most of the workers were at risk of breathing in welding fumes and other welding related gases. This means 92 % of workers were at risk to welding fumes and gases. 68% of the workers did not have protection for the hands, only 32% had. Those workers that had hand protection (32%) had gloves with shorter cuffs and separate sleeves (12%). Others had leather gauntlet gloves with canvas or cuffs (20%). 75% of these workers who had PPE were not using them, only 25% did. Since most of the workers did not use hand protection, this means that their hands were not protected against heat, spatter, and radiation. Most of the workers (72%) did not wear eye protection when removing slag and that put them at risk of eye injuries. All welding operations were not done in a booth. This means that the workers and co-workers were at risk of exposure to welding gases and fumes. 48% of the workplaces had their surroundings with materials that could catch fire. 52% had their surroundings free from burnable material. Therefore almost half of the workplaces were at risk of catching fire. 76% of the working places had no fire extinguishers. Only 24% had fire extinguishers, but only two had been serviced accordingly. The workplaces were less prepared for outbreaks of fire. 68% of the workers took no precautions against burns; they had their sleeves rolled up and forearms without gloves or sleeves when carrying out their work. Only 32% of the workers took precautions against burns. 72% of the workers said that they did not know how to treat burns. Only 28% said they knew how to treat them. 72% of the workplaces did not have first aid kits. The means that they were not prepared for accident, only 28% had first aid kits. 71.4% of the work places had first aid kits without the necessary medicines, bandages, and equipment, only 28.6% had. This indicated a lack of preparedness for accidents on their part. A long-term strategy should be developed aimed at improving the occupational health and safety of the workers. Workers need to be empowered to perform their tasks safely. Workers and owners of informal industries should participate in the formulation of interventions aimed at improving occupational health and safety. The City Council should provide health and safety education and training to the Informal Sector.
268

Coopetition in a regulated market : A study of motivational factors and risks in coopetition

Hennig, Sofia, Malmsten, Anna January 2019 (has links)
Coopetition, the activity of competing firms cooperating, comes with both benefits and risks for the parties involved. The approach to studying coopetition differ among scholars, however the phenomenon continues to be relevant in the area of research with several articles published in recent years. While coopetition has gained momentum in research, what drives coopetition is still argued to be an area that needs further development. Research on coopetition in regulated environments, is especially called for. Therefore, this study has the purpose to explore what motivational factors and risks in coopetition may apply to a regulated market. A case study was conducted by looking into two ongoing coopetition relationships in the Swedish eHealth market. The findings show that there are previously identified motivational factors and risks that are relevant in the context of a technological and regulated market. The study contributes with two propositions that suggest that customer demand and occasional low competitiveness are motivational factors for coopetition in a regulated market. Additionally, the findings resulted in two propositions that enclose financial risks and cultural differences as risks.
269

Outsourcing av ekonomifunktionen : Hur förändras möjligheterna att arbeta med intern kontroll och styrning? / Outsourcing of accounting function : How does the opportunities to work with internal control change?

Johansson, Marcus, Rizk, Gabriella January 2019 (has links)
Syfte: Tidigare forskning har visat att intern kontroll och styrning förändras vid outsourcing av ekonomifunktionen. Emellertid är det mindre beforskat på vilket sätt och hur intern kontroll och styrning förändras vid outsourcing av ekonomifunktionen. Syftet är att öka förståelsen för hur ledningen i företag upplever att möjligheterna att forma och använda intern kontroll och styrning förändras vid outsourcing av ekonomifunktionen. Metod: Studien utgår från ett socialkonstruktivistiskt och hermeneutiskt perspektiv. Studien bygger på en kvalitativ forskningsstrategi och abduktiv ansats. Teoretiska referensramen bygger på tidigare forskning och empirin bygger på tio semistrukturerade intervjuer med företagsledare från tio olika företag. Materialet bearbetades och analyserades för att sedan få fram ett bidrag. Resultat & slutsats: Studiens resultat visar på likheter och skillnader jämfört med tidigare forskning. Vi såg att några företagsledare ansåg att möjligheterna att forma och använda intern kontroll och styrning förändras vid outsourcing av ekonomifunktionen, medan några företagsledare inte har samma åsikt. Kommunikation, kontinuerlig uppföljning, ekonomisk kunskap samt genomförandet av outsourcing av ekonomifunktionen var avgörande faktorer till förändring av intern kontroll och styrning vid outsourcing av ekonomifunktionen. Examensarbetets bidrag: I detta arbete har vi ökat förståelsen för hur ledningen i företag upplever att möjligheterna att forma och använda intern kontroll och styrning förändras vid outsourcing av ekonomifunktionen. Studiens främsta teoretiska bidrag är att genomförandet av outsourcing av ekonomifunktionen förändrar möjligheterna att forma och använda intern kontroll och styrning. Ekonomisk kunskap hos företagsledare, kontinuerlig uppföljning samt kommunikation från leverantören var andra avgörande faktorer. Förslag till fortsatt forskning: Vi föreslår att fortsatt forskning bör studera ett flertal små och stora företag på djupet för att undersöka om storlek på företag förändrar möjligheterna att forma och använda intern kontroll och styrning. Det andra förslaget är att studera hur kunskap, kommunikation och kontinuerlig uppföljning samspelar med varandra. Tredje förslaget är att endast undersöka företagsledare som valt att bygga upp en ekonomifunktion internt med externa resurser. / Aim: Previous research has shown that internal control changes when outsourcing the accounting function. However, it is less researched in which way internal control changes when outsourcing the accounting function. The aim is to provide an enhanced understanding of how managers in companies experience that the opportunities to build and use internal control changes when the accounting function is outsourced. Method: This study is based on a social constructive and hermeneutic perspective. The study has taken a qualitative research strategy and an abductive research approach. The theoretical framework is built on prior research and the empirical data is built on ten semi-structured interviews with managers in ten different companies. The material has been processed and analyzed in order to present a contribution. Result & Conclusions: Study results show similarities and differences with previous research. We saw that some business managers experience that the opportunities to build and use internal control changes when outsourcing the accounting function. while some business managers did not have the same opinion. Communication, continuous monitoring, knowledge in economics and the implementation of outsourcing of the accounting function were crucial factors to changes in internal control when outsourcing the accounting function. Contribution of the thesis: In this work, we have increased the understanding of how business managers in companies experience that the opportunities to build and use internal control changes when outsourcing the accounting function. The main theoretical contribution of the study is that the implementation of outsourcing changes the possibilities of building and using internal control. Knowledge from the business managers, continuous monitoring and communication from the supplier were other crucial factors. Suggestions for future research: We propose that further research should study many small and large companies in depth to investigate whether the size of the companies affects the opportunities to build and use internal control. The second suggestion is to study how knowledge, communication and continuous monitoring interact with each other. The third suggestion is to only investigate business managers who have chosen to build up an accounting function internally with external resources.
270

Hormônios estrógenos no rio do Monjolinho, São Carlos - SP: uma avaliação da problemática dos desreguladores endócrinos ambientais / Estrogen hormones in Monjolinho river, São Carlos - SP: an assessment of environmental endocrine disruptors problems

Reis Filho, Ricardo Wagner 05 September 2008 (has links)
A desregulação endócrina induzida por contaminação ambiental está entre os principais problemas criados pela sociedade moderna de consumo, responsável pela inserção no ambiente de uma série de substâncias interferentes nos sistemas hormonais dos mais diversos organismos, incluindo o próprio homem. A ação destes compostos acarreta, entre outros efeitos, disfunções reprodutivas e estudos apontam que também podem ser indutores de cânceres. A legislação brasileira através do Conselho Nacional do Meio Ambiente (CONAMA) determina os padrões de qualidade das águas, porém muitas substâncias com potencial de desregulação endócrina não tem suas concentrações e emissões especificadas. O objetivo deste trabalho foi executar um levantamento da presença e possíveis conseqüências dos hormônios estrogênicos, uma das classes mais potentes de desreguladores endócrinos (ED), nos compartimentos água e sedimento do rio do Monjolinho. Este rio cruza parte da malha urbana da cidade de São Carlos - SP e recebe lançamentos localizados e difusos de esgotos domésticos e industriais. Portanto, amostras de água e sedimentos foram analisadas através de cromatografia líquida, e exemplares de peixes capturados no rio investigados quanto à presença da proteína vitelogenina (VTG) um biomarcador de exposição. Também ensaios ecotoxicológicos foram desenvolvidos em laboratório com diferentes abordagens para verificação de efeitos diversos. Em uma tentativa de abordar os dados gerados através de uma perspectiva ampla, foi delineada uma avaliação de risco ambiental discutindo as possíveis ameaças a biota e a população humana, já que concentrações de hormônios, principalmente o sintético etinilestradiol (concentração máxima de 30,1 ± 3,41 ng/L), a indução da VTG e efeitos em ensaios ecotoxicológicos foram confirmados. / The environmental endocrine disruption is among the main problems arrived with the modern society way of life. The hormonal systems of several organisms are injured by a number of chemicals disposal on hydric bodies in erroneous way. These compounds causes reproductive disturbs, and studies pointed it be cancer inductors. The Brazilian National Environmental Council (CONAMA) do not regulated standards for discharges and concentrations of these substances. This work aims to investigate the probable presence and effects of sexual estrogens hormones, one of the most powerful groups of endocrine disruptors (EDCs), at the Monjolinho river. This small urban river is placed in São Carlos; a town located in the São Paulo state, southwest Brazil, and receives concentrated and diffuse sewage effluents as industrials as domestics. Samples of water and sediments were analyzed by liquid chromatography, and male fishes captured were investigated to survey the vitellogenin protein (Vtg), a biomarker of exposition. To complement the study, ecotoxicological tests with different approaches were considered. Moreover an environmental risk analyze delineation was made because hormones concentrations, mainly the synthetic ethynilestradiol (EE2), VTG induction, and positive effects in ecotoxicity tests were found.

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