Men's violence against women is an ever-increasing societal issue. The social services bear the responsibility of supporting and protecting women who are victims of violence seeking help. This responsibility has been delegated to social workers based on municipal autonomy. To ensure the safety placements of these women, social workers are guided by standardized assessment tools implemented across municipalities. Previous research suggests that safety assessments might differ depending on where in the country women seek support and protection. The study focuses on investigating the basis upon which social workers ground their safety assessments and whether circumstances exist that cause variations in these assessments across different municipalities. Data from social workers is gathered through eight semi-structured interviews. This empirical data is processed and analyzed using the theoretical concept of scope for action. The study reveals that social workers base their safety assessments on FREDA and conversations with the victims of violence. It discusses the significance of the victim's narrative and how deficiencies in resources and evaluation can lead to discrepancies in assessments. The choice of assessment tools and the scope for action of social workers are questioned.

Engineering-to-order is a production approach that aims to develop each customer order from scratch based on specific requirements, and is therefore inevitably characterised by a high product variety. It is clear that this strategy is costly, but previous research is lacking in terms of providing real-life data regarding how a high product variety affects costs. Therefore, this thesis aims to analyse the cost-variety relationship through a single-case study consisting of observations, interviews as well as calculations, with respect to the value-creating process of a Swedish engineering-to-order business. The results reveal that while the cost of variety may not be influenced at the product level, it can be influenced at the component level. Furthermore, the three aspects that drives component variety cost the most are the number of new components in a product, the number of different components at the company as a whole, as well as the number of different suppliers. Of these, the most influential aspect is the time spent working with new components, which consumes roughly 10% of the total working time throughout the value-creating process. Moreover, the effects of these aspects differ across different parts of the process as well as component types. The results show that the largest costs are driven upstream in the value-creating process and for advanced components. It is however difficult to decrease the variety of advanced components as a rather high variety is required to meet customer needs. Instead, less advanced components offer more easily obtained savings. Finally, the thesis also suggests three ways to mitigate the negative effects of high product variety. Firstly, improving the accessibility and spread of information to ensure internal alignment in the management and maintenance of components. Secondly, identifying common synergies across different projects and products to create economies of scale. And thirdly, explore to what extent processes and components can be standardised.

Yes / Both the season and region in which propolis is collected influence its chemical composition, resulting in variations in biological activity. Significant differences in composition and concentration of certain chemical compounds in propolis make standardisation and quality control challenging. In addition, the lack of uniformity in evaluation methodology and analytical techniques, make it extremely difficult to correlate data across the climatic zones. In this report, we focus on the gaps in propolis research and the challenges they pose for commercialisation, with suggestions as to how we might address them. We hope to stimulate further research which explores the holistic nature of propolis in order to derive a propolis bioactivity standard.

This study sought to critically investigate the contribution of the ordinary people in the creation of a language policy and its subsequent implementation in Zimbabwe. The study was prompted by the realisation of the near-absence of a coherent language policy framework in Zimbabwe. The language policy situation in Zimbabwe is not clearly stated. A hotch-potch of statutes support the status, creation and implementation of languages that are spoken by the citizens of the country. The country’s supreme law, the constitution is silent about the necessity of a broad-based language policy in Zimbabwe. Only three languages Shona, Ndebele and English are considered to be major in a country with 16 known languages. This situation does not support the development of languages particularly the indigenous languages. Indigenous languages are not considered as a suitable medium of instruction from the third year of primary schooling up to tertiary level. Indigenous languages play a critical role in culture, economics and politics. The study argued that ordinary people have creative ways of contributing to the development of a language policy because these people are constantly creating new words and vocabulary that they implement in their day to day struggle with nature and other social classes. Authorities in Zimbabwe are yet to view the role of indigenous languages in development as a cornerstone of socio-economic and political progress. African languages, particularly the Shona language that was the main unit of analysis in this study revealed its capacity to handle complex ideas. It was recommended that when Shona and other indigenous languages are accorded the status of official languages of the country and then provided with the financial resources and linguistic expertise to develop them then, a coherent language policy can become a living reality in Zimbabwe. / Africam Languages / D. Litt. et Phil. (African Languages)

Die Standardisierung von Geschäftsprozessen ist ein innovativer Ansatz zur Steigerung der Wettbewerbsfähigkeit von Unternehmen. Die vorliegende Arbeit hat dazu die Entwicklung einer Methode zum Gegenstand. Dabei wird zunächst ein Instrument entwickelt, mit dessen Hilfe Prozesse auf Standardisierbarkeit überprüft werden können. Standardisierbare Prozesse werden im Anschluss auf elementarer Ebene auf Vielfalt untersucht, mit dem Ziel ausschließlich positive Vielfalt in Prozessen zuzulassen. Die entwickelten Instrumente und erforderlichen Aktivitäten zur Standardisierung von Prozessen werden in Form von Methodenfragmenten beschrieben und stellen in der Summe die Methode zur Prozessstandardisierung dar.

The future of human embryonic stem cell (hESC) research with regards to their applicability in a therapeutic setting, relies on the development and standardisation of consistent and robust methods to demonstrate their defining characteristics; their pluripotent ability to form all three germ layers and their capacity for self-renewal. Although much research has been carried out to investigate new methods of culturing hESCs, many of these studies have not robustly concluded the impact of prolonged culture on genetic and genomic stability nor have they examined in any comparative detail the impact of the culture conditions such as differences in feeders used or the media composition in which the stem cells are cultured in. The aim of this thesis therefore was to investigate and evaluate methods for improving the uniform and robust culture and characterisation of hESCs over prolonged periods in culture. Four hESC lines ( RH5, HUES9, SHEF1 and NCL5) were chosen on the basis that they had not previously been well characterised and therefore could potentially benefit the wider stem cell community by increasing diversity, rather than continue to use the already small subset of well publicised lines. The RH5, HUES9, SHEF1 and NCL5 cells were subjected to long term passaging using recombinant enzyme TrypLE™ Express, on human feeders, mouse feeders and feeder free matrix Matrigel in combination with defined media mTeSR1, for uniform scale up. Changes in characteristic stem cell surface markers were compared using two techniques; flow cytometry and quantitative in situ fluorescence microscopy. Genomic stability was assessed by real time PCR. Chromosomal integrity was monitored using array genomic hybridisation (aCGH). Array genomic hybridisation analysis of cells cultured for 20 passages by enzymatic passaging revealed changes in copy number variations in all the stem cell lines. Aberrations on chromosomes 12, 17 and 20, appeared most commonly as a result of long term culture. Although no significant differences were seen between hESCs cultured on mouse and human feeders, cultures on Matrigel showed fewer detected chromosomal aberrations. Expression of cell surface stemness markers SSEA3, SSEA4, TRA1-60 and TRA1-81 were maintained by hESC cultured on all matrices and confirmed by the use of flow cytometry and high throughput quantitative immunofluorescence imaging using the TissueFaxs™ cell analysis microscopy system. In depth imaging revealed subtle but important differences in the way in which hESCs attach and proliferate on different matrices. Genetic profiling of each of the stem cell lines using Taqman Low density array cards to assess the expression of 96 genes by Real Time PCR, demonstrated the continued expression of stemness genes 21 at late passage, and low level expression of differentiation genes, inherent to particular stem cell lines. Although both mouse and human feeders and Matrigel support the undifferentiated growth of hESCs, subtle differences from the hESCs were seen as a result of their use, most obviously, changes in morphology and how they proliferate. This was further explored in the stem cell line NCL5, as it demonstrated a readiness to adapt to new matrices, better chromosomal stability and higher expression of cell surface markers compared with the other hESC lines. Using in vitro differentiation assays to all three germ layers, NCL5 cultured to late passage (p+20) on human feeder iMRC5, mouse feeder iMEF and feeder free matrix Matrigel, demonstrated the ability to differentiate to ectoderm, endoderm and mesoderm progenitors after induction using three 7 day flat based directed differentiation protocols. Altered differentiation patterns were detected by Real Time PCR and TissueFaxs™ imaging and quantitative analysis, as a consequence of the prolonged culture on the specific matrices used. Such key findings allude to the strong influences of microenvironment and will help to improve the standardisation of in vitro differentiation assays. From these studies, chromosomal changes had no impact on NCL5 stem cell lines‘ ability to form progenitors, however small genetic instabilities may still play a role in terminal differentiation of germ lineage specific cell types. The findings of the programme of work described has led to the successful culture methods and characterisation testing validated in this project being incorporated into routine culture and banking of research grade hESCs at the UK Stem Cell Bank. These protocols will now be made more widely available and should assist stem cell researchers in adopting the most suitable and optimum conditions for culturing stem cells in the undifferentiated and stable state. With the huge surge in stem cell research over the past decade, the development of robust characterisation and culture methods will undoubtedly have significant impact on the exploitation of these cells for regenerative medicine and to assist with this a future aim of the stem cell bank will be to standardise methodologies for clinical grade banking.

Thesis (LLD (Mercantile Law))--University of Stellenbosch, 2010. / ENGLISH ABSTRACT: International sales contracts have very specific needs that stem from the multiplicity of legal systems which apply to such contracts. In addition to harmonised law, mercantile custom is able to address many of these needs. Mercantile custom represents usages which are clear, certain and efficient and are expected to be known and applied by merchants in a particular trade or region. To this extent mercantile custom fulfils an automatic harmonisation function. However, where a custom does not enjoy uniform application across all branches of trade, the harmonisation function of mercantile custom is limited, as is the case with trade terms. Trade terms reflect mercantile customs and usages which developed over a long time in order to simplify the trade in goods that are transported from one place to the other. They regulate the delivery obligations of the seller and buyer as well as associated obligations such as the passing of risk. Trade terms negate the need for elaborate contract clauses and appear in abbreviated form in contracts of sale. Although they provide a uniform expression of mercantile custom in a particular location or trade, the understanding of trade terms tend to differ from country to country, region to region or from one branch of trade to the next. The ICC INCOTERMS is an effort to standardise trade term definitions at the hand of the most consistent mercantile customs and practices. The aim of this study is to investigate the efficiency of INCOTERMS as a form of standardisation in international sales law. For purposes of the investigation the focus is limited to the passing of risk. Although national laws usually have a default risk regime in place, merchants still prefer to regulate risk by means of trade terms. This study will investigate the legal position in the case of FOB, CIF and DDU terms. An analysis of the risk regimes of a few selected national systems will show that each has their own understanding of these trade terms. The United Nations Convention on Contracts for the International Sale of Goods (CISG) does not refer to trade terms, but many commentators have concluded that the CISG risk rule is consistent with INCOTERMS. The study will discuss this in more detail. To determine the efficiency of INCOTERMS as a form of standardisation in international sales law, the study examines their characteristics, legal nature as well as their limited scope of regulation. Specific emphasis is placed on the interplay between the CISG and INCOTERMS and the possibility of some form of interaction and collaboration between the two instruments. It is concluded that collaboration between INCOTERMS and the CISG adds value to the international law of sales by increasing the efficiency of an international business transaction and thereby facilitating international trade. / AFRIKAANSE OPSOMMING: Internasionale koopkontrakte het spesifieke behoeftes wat voortspruit uit die veelvoudigheid van regstelsels van toepassing op so ‘n kontrak. Baie van hierdie behoeftes kan aangespreek word deur geharmoniseerde regsreëls in samehang met handelsgewoontes en –gebruike. Handelsgewoontes verteenwoordig duidelike, seker en effektiewe gebruike. Daar word dus van handelaars wat in ‘n bepaalde bedryf of streek handel dryf, verwag om van hierdie gebruike kennis te neem en hulle toe te pas. In hierdie konteks vervul handelsgebruike ‘n outomatiese harmoniseringsfunksie. Waar ‘n gebruik nie eenvormig toegepas word oor alle bedrywe heen nie, is die harmoniseringsfunksie van handelsgebruike egter beperk. Handelsterme bied ‘n tipiese voorbeeld hiervan. Handelsterme verteenwoordig bepaalde handelsgewoontes en –gebruike wat oor ‘n geruime tyd ontwikkel het ten einde handel in goedere wat van een plek na die ander vervoer word, te vergemaklik. Hulle reguleer die leweringsverpligtinge van die verkoper en koper asook ander verpligtinge wat met lewering verband hou, soos byvoorbeeld die oorgang van risiko. Handelsterme doen weg met lang en omslagtige kontraksbedinge aangesien hulle in die vorm van afkortings in die kontrak figureer. Alhoewel handelsterme ‘n uniforme uitdrukking van gebruike in ‘n bepaalde gebied of bedryf verteenwoordig, is dit egter so dat die inhoud van handelsterme van land tot land, streek tot streek of van een tipe bedryf tot die ander verskil. INCOTERMS is ‘n poging om die inhoud van handelsterme te standaardiseer aan die hand van die mees eenvormige handelsgewoontes en –gebruike. Die doel van hierdie studie is om die effektiwiteit van INCOTERMS as ‘n vorm van standaardisering in die internasionale koopreg te ondersoek. Vir doeleindes van die ondersoek word die fokus beperk tot die oorgang van risiko. Al het nasionale regstelsels gewoonlik ‘n verstek risiko-reël in plek, verkies handelaars steeds om risiko by wyse van handelsterme te reguleer. Die studie ondersoek die regsposisie in die geval van FOB-, CIF-, en DDU-terme. ‘n Analise van risiko-regulering in ‘n aantal nasionale sisteme toon dat elk hul eie betekenis heg aan die inhoud van hierdie terme. Alhoewel die Weense Koopkonvensie geensins na handelsterme verwys nie, voer verskeie kommentatore aan dat die Konvensie se risiko-bestel verenigbaar is met dié van INCOTERMS en sal hierdie aspek gevolglik in meer besonderhede in die studie aangespreek word. Ten einde die effektiwiteit van INCOTERMS te bepaal, word daar ondersoek ingestel na hulle kenmerke, regsaard en beperkte aanwendingsgebied. Spesiale klem word gelê op die wisselwerking tussen die Weense Koopkonvensie en INCOTERMS asook die moontlikheid van interaksie en samewerking tussen die twee instrumente. Die gevolgtrekking is dat interaksie tussen die Koopkonvensie en INCOTERMS waarde toevoeg tot die internasionale koopreg deur die effektiwiteit van die internasionale besigheidstransaksie te verhoog en gevolglik internasionale handel te bevorder. / Harry Crossley Fund / NRF Thuthuka Fund

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal.

Die Arbeit untersucht die Durchsetzung von Ansprüchen auf Unterlassung aus standardessentiellen Patenten (SEP). Ausgehend von den ökonomischen und rechtsdogmatischen Grundlagen des Patentrechts wird zunächst die Legitimation des Anspruchs auf Unterlassung im Gefüge des Patentrechts untersucht und der Frage nachgegangen, inwieweit die Gewährung von Ausschließlichkeitsbefugnissen zur Verwirklichung der Ziele von Innovationsschutz und -förderung notwendig ist. Die Prüfung kommt zu dem Schluss, dass die Ausübung des Anspruchs auf Unterlassung aus SEP unter Umständen eine ökonomisch und rechtsdogmatisch unerwünschte Blockadeposition herbeiführen kann, so dass eine Einschränkung des Anspruchs zur Sicherung der innovationsfördernden Funktionen des Patentrechts geboten sein kann. Sodann werden verschiedene Lösungsansätze diskutiert und dabei besonderes Augenmerk auf die durch die deutsche und europäische Rechtsprechung entwickelte kartellrechtliche Lösung gelegt. Nach einer Betrachtung der Tatbestandsmerkmale des kartellrechtlichen Verbots des Missbrauchs von Marktmacht nach Art. 102 AEUV bzw. §§ 19, 20 GWB und deren Anwendung auf Fälle der Erhebung von Unterlassungsklagen aus SEP wird diese Lösung abgelehnt. Der Tatbestand des Missbrauchs von Markmacht vermag wegen der Fokussierung auf (Produkt-)märkte und des Erfordernisses einer marktbeherrschenden Stellung als Anwendungsvoraussetzung bei stringenter Auslegung der Vorschrift nicht alle relevanten Fälle zu fassen. Im Folgenden werden Ansätze diskutiert und bewertet, welche eine rechtliche Verankerung der Einschränkung des Anspruchs auf Unterlassung eher im Vertrags- oder im Patentrecht selbst suchen. Als Ergebnis wird sich schließlich dafür ausgesprochen, das in § 23 PatG für die Abgabe einer Lizenzbereitschaftserklärung vorgesehene Verfahren mit seinen wechselseitigen Pflichten analog auf Fälle der Erhebung einer Unterlassungsklage aus SEP anzuwenden und die Zulässigkeit der Erhebung von Unterlassungsklagen nach diesem Maßstab zu beurteilen. / The work analyzes the enforcement of claims for injunctive relief based on standard-essential patens (SEP). Taking the economic and legal foundations of patent law as a starting point, the legitimacy of the claim for injunctive relief within the system of patent law is assessed, as is the question of whether granting the power to exclude others from use of a patented technology is necessary for protecting and promoting innovation. It is found that injunctive relief based on a SEP can lead to an economically and legally unwanted blocking position, in favor of the patent holder, which may require restricting the exclusive right of the patent holder in order to ensurethe patent's function of promoting innovation. Following this, different approaches for solving the issue are discussed. A special focus is put on antitrust law which has been used as a basis to limit injunctive relief by the German and European courts. After considering the elements of Art. 102 TFEU, §§ 19, 20 of the German Antitrust Code (GWB) respectively, the application of antitrust law is rejected. Due to its focus on (product-)markets and the requirement of a dominant market position, antitrust law is not fit to sufficiently limit the negative impact that injunctive relief from a SEP might have on innovation. The work further discusses and assesses other approaches which are trying to apply contract law or certain provisions of patent law. As a result, it is suggested to analogously apply the procedure set out in § 23 PatG (German Patent Code) and its system of mutual obligations to assess the legitimacy of injunctive relief in SEP-cases

Cette thèse comprend deux parties relativement distinctes. Dans la première, nous présentons l'analyse de 16 millions de courbes de lumière collectées par EROS II vers différentes longitudes dans le plan Galactique durant 7 saisons d'observation. Après avoir crée des images de référence et des courbes de lumière, nous avons recherché des effets de microlentille gravitationnelle parmi les courbes de lumière produites en appliquant une analyse discriminante, tout en calculant notre efficacité de détection sur un lot de courbes de lumière simulées. Nous avons mis en évidence 24 candidats, ce qui nous a permis de mesurer la profondeur optique vers nos cibles. La profondeur optique moyenne vers les bras spiraux est $<\tau_(GSA)> = 0.38\pm0.08$. Notre résultat est compatible avec les prédictions de modèles Galactiques tirés de la littérature, dans lesquels le bulbe central est modélisé par une barre, et favorise ceux sans matière cachée dans le disque. Outre la statistique, la principale limi tation dans notre analyse provient du fait que les distances où sont situées les étoiles cibles sont mal connues.<br> Dans la seconde partie, nous présentons l'analyse des données spectroscopiques, collectées durant une campagne internationale de recherche de supernovae Ia menée au printemps 1999, à laquelle EROS II a participé. Une vingtaine de supernovae Ia ont été découvertes puis suivies pendant cette campagne. Nous avons réduit les données spectroscopiques les concernant, qui consistent en une centaine de spectres au total. Nous avons developpé pour celà un programme original permettant de séparer le flux de la supernovae de celui de sa galaxie hôte. Nous avons ensuite procédé à une étude de stan dardisations sur un lot regroupant des objets de la campagne 1999 et des objets découverts antérieuement. L'étude sur ces 17 supernovae Ia a permis de confirmer l'interêt des spectres pour la standardis ation. Elle montre en particulier que la standardisation à partir de spectres est aussi efficace que celle basée sur le taux de décroissance des courbes de lumière.