The master thesis "Zikmund Reach and his photographic collection" focuses on Zikmund Reach's photographs of old Prague. Firsty theis describes the history of Czech photography, which if followed by the topic of Prague's redevelopment and its influence on photography. The main topic is based on the photographic albums of "Disappeared Prague" and a extensive collection of "Prague types", which is a period, sociological reflecion of society in the second half of 19th century. Finally the thesis focuses on archives in which is the collection of Zikmund Reach stored in and their mutual thematic coherence. In conclusion the thesis focuses on the Institute of Art History Academy of Sciences of the Czech Republic and its collection of photographs which come from the collection of Zikmund Reach.

Esse estudo analisou os efeitos de 10 semanas de treinamento contra resistência, sobre a composição corporal, a força muscular e a flexibilidade de 11 mulheres idosas (68,91 ± 5,43 anos). Um grupo de 8 idosas (65,13 ±4,09 anos) serviu como controle inativo. A força de preensão manual (ambas as mãos), o percentual de gordura corporal (dobras cutâneas e bioimpedância) e a flexibilidade (teste \"sentar e alcançar\") foram avaliados antes e após 10 semanas. A força muscular isotônica foi avaliada pelas cargas de treinamento. Após as avaliações iniciais, os indivíduos começaram o programa de treinamento que consistiu de oito exercícios (peito, costas, ombro, bíceps, tríceps, coxa, panturrilha e abdome), sem a realização de exercício para flexibilidade. O programa de treinamento resultou em aumentos significativos (p< 0,001) na força muscular isotônica, para todos os exercícios, com aumentos percentuais que variaram de 25,91% a 49,09%, para tríceps e panturrilha, respectivamente. Verificaram se aumentos significativos (p < 0,001) na força de preensão manual de ambas as mãos e também na flexibilidade no grupo submetido a treinamento. O programa de treinamento não resultou em alteração na gordura corporal avaliada por bioímpedância e equação de dobras cutâneas, contudo verificou-se redução no &#931; 8DC (p&#8804;0,01). Não foram observadas alterações no grupo controle, em nenhuma variável investigada. Conclui-se que o programa de treinamento utilizado foi eficaz para aumentar a força muscular e a flexibilidade das mulheres idosas, reduzir o &#931; 8DC, contudo não provocou redução do percentual de gordura corporal. / This study analyzed the effects of a 10-wk resistance training program on body composition, muscle strength and flexibility in 11 elderly women (68.91 ± 5.43 yr.). A control group of 8 women (65.13 ± 4.09 yr.) served as inactive controls. Hand grip strength (both hands), body fat percent (skinfold thickness and bioelectrical impedance) and flexibility ( \"sit and reach\" test) were assessed before and after 10 weeks . The isotonic muscle strength were assessed by the weight of training . After initial tests, the subjects began a training program consisting of eight exercises for all body (chest, back, shoulder, biceps, triceps, thigh, calf and abdomen), without flexibility exercises. The training program resulted in significant increase (p< 0.001) in isotonic muscle strength, for all exercises, with increases ranged from 25.91% to 49.09%, for triceps and calf, respectively. It was observed significant increase (p<0,001) in hand grip strength (both hands) and flexibility in the training group. The training program resulted in no decrease in body fat assessed by bioelectrical impedance and skinfold thickness equation, but we observed decrease in &#931; 8ST (p&#8804; 0.01). No significant changes were observed in the control group by ariy variable. In conclusion, the training program utilized was effective in increase muscle strength, flexibility and reduced &#931; 8ST. However, the training program did not reduce body fat percentage.

Esse estudo analisou os efeitos de 10 semanas de treinamento contra resistência, sobre a composição corporal, a força muscular e a flexibilidade de 11 mulheres idosas (68,91 ± 5,43 anos). Um grupo de 8 idosas (65,13 ±4,09 anos) serviu como controle inativo. A força de preensão manual (ambas as mãos), o percentual de gordura corporal (dobras cutâneas e bioimpedância) e a flexibilidade (teste \"sentar e alcançar\") foram avaliados antes e após 10 semanas. A força muscular isotônica foi avaliada pelas cargas de treinamento. Após as avaliações iniciais, os indivíduos começaram o programa de treinamento que consistiu de oito exercícios (peito, costas, ombro, bíceps, tríceps, coxa, panturrilha e abdome), sem a realização de exercício para flexibilidade. O programa de treinamento resultou em aumentos significativos (p< 0,001) na força muscular isotônica, para todos os exercícios, com aumentos percentuais que variaram de 25,91% a 49,09%, para tríceps e panturrilha, respectivamente. Verificaram se aumentos significativos (p < 0,001) na força de preensão manual de ambas as mãos e também na flexibilidade no grupo submetido a treinamento. O programa de treinamento não resultou em alteração na gordura corporal avaliada por bioímpedância e equação de dobras cutâneas, contudo verificou-se redução no &#931; 8DC (p&#8804;0,01). Não foram observadas alterações no grupo controle, em nenhuma variável investigada. Conclui-se que o programa de treinamento utilizado foi eficaz para aumentar a força muscular e a flexibilidade das mulheres idosas, reduzir o &#931; 8DC, contudo não provocou redução do percentual de gordura corporal. / This study analyzed the effects of a 10-wk resistance training program on body composition, muscle strength and flexibility in 11 elderly women (68.91 ± 5.43 yr.). A control group of 8 women (65.13 ± 4.09 yr.) served as inactive controls. Hand grip strength (both hands), body fat percent (skinfold thickness and bioelectrical impedance) and flexibility ( \"sit and reach\" test) were assessed before and after 10 weeks . The isotonic muscle strength were assessed by the weight of training . After initial tests, the subjects began a training program consisting of eight exercises for all body (chest, back, shoulder, biceps, triceps, thigh, calf and abdomen), without flexibility exercises. The training program resulted in significant increase (p< 0.001) in isotonic muscle strength, for all exercises, with increases ranged from 25.91% to 49.09%, for triceps and calf, respectively. It was observed significant increase (p<0,001) in hand grip strength (both hands) and flexibility in the training group. The training program resulted in no decrease in body fat assessed by bioelectrical impedance and skinfold thickness equation, but we observed decrease in &#931; 8ST (p&#8804; 0.01). No significant changes were observed in the control group by ariy variable. In conclusion, the training program utilized was effective in increase muscle strength, flexibility and reduced &#931; 8ST. However, the training program did not reduce body fat percentage.

This creative project was developed as a supplement to the external stakeholder assessment component of the strategic planning process that Reach for Youth, Inc. (RFY)-a nonprofit youth organization located in Indianapolis, Indiana-adopted to create its strategic plan for 2002 to 2005. It supplemented the larger strategic planning process by positively engaging youth in focus group activities using surveys, creative exercises, and questionnaires, to attain their input and feedback, as program participants and primary stakeholders in the agency. As a result, youth participation validated the overall process, substantiated RFY's interest in expanding programs, influenced identification of critical issues that formed the basis of the plan, and sparked an organizational conversation about youth participation in the agency. The youth not only provided important feedback that informed RFY's strategic plan, they also were given a meaningful opportunity to express themselves as individuals, and had their roles in and contributions to the agency affirmed. / Department of Urban Planning

Industrial chemicals in European Union produced or imported in volumes above 1 tonne annually, necessitate a registration within REACH. A common problem, concerning these chemicals, is deficient information and lack of data for assessing the hazards posed to human health and the environment. Animal studies for the type of toxicological information needed are both expensive and time consuming, and to that an ethical aspect is added. Alternative methods to animal testing are thereby requested. REACH have called for an increased use of in silico tools for non-testing data as structure-activity relationships (SARs), quantitative structure-activity relationships (QSARs), and read-across. The main objective of the studies underlying this thesis is related to explore and refine the use of in silico tools in a risk assessment context of industrial chemicals. In particular, try to relate properties of the molecular structure to the toxic effect of the chemical substance, by using principles and methods of computational chemistry. The initial study was a survey of all industrial chemicals; the Industrial chemical map was created. A part of this map was identified including chemicals of potential concern. Secondly, the environmental pollutants, polychlorinated biphenyls (PCBs) were examined and in particular the non-dioxin-like PCBs (NDL-PCBs). A set of 20 NDL-PCBs was selected to represent the 178 PCB congeners with three to seven chlorine substituents. The selection procedure was a combined process including statistical molecular design for a representative selection and expert judgements to be able to include congeners of specific interest. The 20 selected congeners were tested in vitro in as much as 17 different assays. The data from the screening process was turned into interpretable toxicity profiles with multivariate methods, used for investigation of potential classes of NDL-PCBs. It was shown that NDL-PCBs cannot be treated as one group of substances with similar mechanisms of action. Two groups of congeners were identified. A group including in general lower chlorinated congeners with a higher degree of ortho substitution showed a higher potency in more assays (including all neurotoxic assays). A second group included abundant congeners with a similar toxic profile that might contribute to a common toxic burden. To investigate the structure-activity pattern of PCBs effect on DAT in rat striatal synaptosomes, ten additional congeners were selected and tested in vitro. NDL-PCBs were shown to be potent inhibitors of DAT binding. The congeners with highest DAT inhibiting potency were tetra- and penta-chlorinated with 2-3 chlorine atoms in ortho-position. The model was not able to distinguish the congeners with activities in the lower μM range, which could be explained by a relatively unspecific response for the lower ortho chlorinated PCBs. / Den europeiska kemikalielagstiftningen REACH har fastställt att kemikalier som produceras eller importeras i en mängd över 1 ton per år, måste registreras och riskbedömmas. En uppskattad siffra är att detta gäller för 30 000 kemikalier. Problemet är dock att data och information ofta är otillräcklig för en riskbedömning. Till stor del har djurförsök använts för effektdata, men djurförsök är både kostsamt och tidskrävande, dessutom kommer den etiska aspekten in. REACH har därför efterfrågat en undersökning av möjligheten att använda in silico verktyg för att bidra med efterfrågad data och information. In silico har en ungefärlig betydelse av i datorn, och innebär beräkningsmodeller och metoder som används för att få information om kemikaliers egenskaper och toxicitet. Avhandlingens syfte är att utforska möjligheten och förfina användningen av in silico verktyg för att skapa information för riskbedömning av industrikemikalier. Avhandlingen beskriver kvantitativa modeller framtagna med kemometriska metoder för att prediktera, dvs förutsäga specifika kemikaliers toxiska effekt. I den första studien (I) undersöktes 56 072 organiska industrikemikalier. Med multivariata metoder skapades en karta över industrikemikalierna som beskrev dess kemiska och fysikaliska egenskaper. Kartan användes för jämförelser med kända och potentiella miljöfarliga kemikalier. De mest kända miljöföroreningarna visade sig ha liknande principal egenskaper och grupperade i kartan. Genom att specialstudera den delen av kartan skulle man kunna identifiera fler potentiellt farliga kemiska substanser. I studie två till fyra (II-IV) specialstuderades miljögiftet PCB. Tjugo PCBs valdes ut så att de strukturellt och fysiokemiskt representerade de 178 PCB kongenerna med tre till sju klorsubstituenter. Den toxikologiska effekten hos dessa 20 PCBs undersöktes i 17 olika in vitro assays. De toxikologiska profilerna för de 20 testade kongenerna fastställdes, dvs vilka som har liknande skadliga effekter och vilka som skiljer sig åt. De toxicologiska profilerna användes för klassificering av PCBs. Kvantitativa modeller utvecklades för prediktioner, dvs att förutbestämma effekter hos ännu icke testade PCBs, och för att få ytterligare kunskap om strukturella egenskaper som ger icke önskvärda effekter i människa och natur. Information som kan användas vid en framtida riskbedömning av icke-dioxinlika PCBs. Den sista studien (IV) är en struktur-aktivitets studie som undersöker de icke-dioxinlika PCBernas hämmande effekt av signalsubstansen dopamin i hjärnan.

El plan de carga del buque debe adherirse a las instrucciones de estiba del operador del buque. Estas instrucciones especifican las características generales de cada contenedor que habrá de ccargarse. El plan de carga también debe agilizar las operaciones de transporte en la explanada de la terminal. Presentamos dos algoritmos para generar el plan de carga. El primero utiliza el método de descomposición Lagrangeana. El segundo utiliza la metaheurística tabú. Las companías navieras se enfrentan a un problema extremadamente complejo cuando intentan determinar la composición y ruteo óptimo de su flota. Presentamos un modelo y algoritmo para este problema. El modelo representa los costes operativos de una naviera. También permite la respresentación de buques con diferentes propiedades, puntos y costes de transbordo, retrasos en puerto, y la posibilidad de rechazar una solicitud de transporte. Un caso práctico explora la sensitividad de los resultados a cambios en el precio del combustible. / The vessel loading plan must comply with stowage instructions provided by the vessel operator, which specify characteristics of each container to be loaded. Additionally, the vessel loading plan should expedite transport operations in the yard. We present two vessel planning algorithms. In the first model, the vessel planning problem is formulated as a mixed integer programming (MIP) model and solved using Lagrangean relaxation and branch and bound. In the second model, a tabu metaheuristic is employed. Liner companies face a complex decision problem in determining the optimal fleet composition and routing. We present a model that captures the revenues and operating expenses of a liner company. The model allows for vessel types with different cost and operating properties; transhipment hubs; port delays; regional trade imbalances; and the possibility of rejecting transportation demand selectively. A case study explores the sensitivity of optimal fleet composition and routing to bunker costs.

Submitted by Pedro Mizukami (pedro.mizukami@fgv.br) on 2011-01-05T17:56:38Z No. of bitstreams: 1 DMPPJ - SOREAN MENDES DA SILVA THOME.pdf: 1155783 bytes, checksum: 0e82c5120857e7f28d9ba92ad1bc8433 (MD5) / Approved for entry into archive by Pedro Mizukami(pedro.mizukami@fgv.br) on 2011-01-05T19:15:57Z (GMT) No. of bitstreams: 1 DMPPJ - SOREAN MENDES DA SILVA THOME.pdf: 1155783 bytes, checksum: 0e82c5120857e7f28d9ba92ad1bc8433 (MD5) / Made available in DSpace on 2011-02-18T11:36:25Z (GMT). No. of bitstreams: 1 DMPPJ - SOREAN MENDES DA SILVA THOME.pdf: 1155783 bytes, checksum: 0e82c5120857e7f28d9ba92ad1bc8433 (MD5) Previous issue date: 2010 / The aim of this research is to analyze the Law number 9.957/2000, which established the process accelerated, in the process of labor. It seeks to identify models of procedures used in the labor lawsuit, mainly at procedure accelerated and its efficiency within the organizational structure of the labour court. It also shows the necessity of compliance with law number 9.957/2000 as a feasible tool for effective adjudication of the labour Court in cases with amount estimated is below forty salaries. In order to achieve these aim, we approached initially background´s law aspects to reach at justice, constitutional principles of reasonable timing of proceeding and legal certainty, so the comprehension and union of labour laws. Another aspect of this research shows the search for revolutionary changes in the organization structure of the labour court for a hole applicability of the procedure accelerated, due to overload of cases in progress at court. We attempt to analyze the labour court employee’s point of view about the accelerated procedure, activy as an effective tool in seeking a quickly adjucation and finally efficient. Finally the proposal is the creation of special courts to trial of labor cases in progress before the accelerated procedure, as a tool to speed up the law activity and decrease the time of the labor case. / Através desta pesquisa, analisa-se a lei 9.957/2000, que instituiu o procedimento sumaríssimo no processo do trabalho. Procura-se identificar os modelos de procedimentos utilizados na tramitação do processo trabalhista, notadamente o procedimento sumaríssimo e sua eficácia, dentro da estrutura organizacional da Justiça do Trabalho. Busca-se demonstrar a necessidade do cumprimento da lei n. 9.957/2000, como instrumento viável para uma efetiva prestação jurisdicional da Justiça do Trabalho, nas ações de valor abaixo de quarenta salários mínimos. Para atingir tais propósitos, abordam-se, inicialmente, aspectos teóricos fundamentais relacionados ao acesso à justiça, aos princípios constitucionais da duração razoável do processo e da segurança jurídica e, ainda, a interpretação e integração da legislação trabalhista. Em um segundo momento, demonstra-se a necessidade de reforma na estrutura organizacional da Justiça do Trabalho para uma integral aplicabilidade do procedimento sumaríssimo, em face da sobrecarga de processos em tramitação nas varas do trabalho. Analisa-se, também, a visão dos operadores do Direito do Trabalho, jurisdicionados e serventuários da Justiça do Trabalho sobre o procedimento sumaríssimo, na qualidade de instrumento eficaz na busca de uma prestação jurisdicional célere e, por isso, efetiva. Por fim, expõe-se a proposta de criação de varas do trabalho específicas para julgamento de processos tramitados pelo procedimento sumaríssimo, como instrumento de celeridade da atividade jurisdicional e de redução do tempo de duração do processo trabalhista.

Les enceintes de confinement des centrales nucléaires sont conçues pour assurer des propriétés de confinement et d'étanchéité précises en situations d'usage normal et en cas d'accident nucléaire, afin d'éviter la dissémination de radioéléments dans l'environnement. Ces enceintes étant construites en béton, la maîtrise de l'évaluation de la perméabilité du béton et de ses évolutions sous contraintes permettrait d'évaluer les débits de fuite susceptibles d'intervenir dans le temps sous certaines sollicitations. Jusqu'aujourd'hui, il existe plusieurs techniques de mesure de la perméabilité et ces techniques aboutissent à des résultats différents pour une même éprouvette de béton. La première étude que nous avons réalisée a été donc de proposer une normalisation de la mesure de la perméabilité : cette normalisation a abouti à la détermination d'une perméabilité caractéristique du béton et indépendante de la technique de mesure. Parallèlement à cette démarche, nous avons aussi proposé d'évaluer la perméabilité du béton à l'aide d'observables du Contrôle Non Destructif comme la permittivité et la résistivité électrique. Les résultats obtenus montrent la possibilité d'estimer la perméabilité dans les conditions du béton sur site. La deuxième étude réalisée est relative à la maîtrise de la perméabilité sous contraintes. Au laboratoire, nous avons étudié la perméabilité d'éprouvettes en béton de différentes tailles dans diverses conditions de séchage, de sollicitation thermique, d'endommagements mécanique et couplés. Nous avons ainsi pu établir des modèles perméabilité-endommagements en fonction de chaque source d'endommagement. La troisième étude réalisé porte sur la transposition des résultats de laboratoire au site, à travers l'utilisation de maquette d'enceinte nucléaire de dimensions plus importantes et représentatives de l'ouvrage réel (VeRCoRs à l'échelle 1/3). L'ensemble des résultats des deux premières études ont été mise à contribution et ont permis d'aboutir à des calculs des débits de fuite et des Temps d'Etablissement du Régime Permanent d'Ecoulement cohérents avec les hypothèses de calculs. / The building reactor of the nuclear power plants are designed to provide precise containment and sealing properties in normal use situations and in the event of a nuclear accident, to prevent the spread of radioelements in the environment. Since these enclosures are made of concrete, controlling the evaluation of the permeability of concrete and its evolutions under stress would make it possible to evaluate the leakage rates that may occur over time under certain conditions. Until today, there are several techniques for measuring permeability and these techniques lead to different results for the same concrete specimen. The first study we carried out was therefore to propose a standardization of the permeability measurement: this standardization resulted in the determination of a characteristic permeability of concrete and independent of the measurement technique. In parallel with this approach, we also proposed to evaluate the permeability of concrete using observables from Non-Destructive Testing such as permittivity and electrical resistivity. The results obtained show the possibility of estimating the permeability under concrete conditions on site. The second study carried out relates to the control of the permeability under constraints. In the laboratory, we investigated the permeability of concrete specimens of different sizes under various conditions of drying, thermal stress, mechanical and coupled damage. We could establish permeability-damage models according to each source of damage. The third study carried out relates to the transposition from laboratory results to the site, using nuclear power plants mock-up of larger dimensions and representative of the actual structure (VeRCoRs at scale 1/3). All the results of the first two studies have been used and have led to calculations of leak rates and Time to Reach Steady State (TRSS) consistent with the calculation assumptions.

Diploma work provides description of a drug scene in the region Jindřichův Hradec. It characterizes recent network of services, and presents process as well as basic models of Harm Reduction services optimalization. It also provides analysis and description of problem drug use in four towns within the region {--} it is Jindřichův Hradec, Třeboň, Dačice and a smaller town České Velenice. Next to the analysis and description of recent situation the diploma work also attempts to estimate possible development of drug scene as well as drug services in the near future.

Chemicals offer a wide range of desired functions and are used in a variety of consumer goods and industrial sectors. The number of individual synthetic organic chemicals produced and the total global chemical production volume are increasing. The majority of these anthropogenic chemicals are not monitored in environmental matrices nor in the indoor environment even though some are associated with undesirable consequences and the range of possible chemical impacts is still far from being fully understood. Chemicals that remain in the environment for a long time and/or distribute over a large area have high exposure potential, and will present particularly acute challenges if a currently unknown undesirable effect is discovered.  This thesis describes the development of a set of in silico methods to identify and prioritize chemicals with high exposure potential that are currently not subject to national or international restrictions. In brief, we i) compiled databases of contaminants of potential concern, ii) established models to predict key properties to fill data gaps in the absence of experimental data, and iii) developed and applied methods to screen chemicals to identify those that should be assigned high priority for future study.  Paper I delivers screening-level models to predict partition ratios of organic chemicals between polymeric materials commonly found indoors, and both air and water. These models can be used in high-throughput exposure assessment studies, passive sampling experiments, and models of emissions, fate and transport of chemicals.  Paper II presents a scoring method to prioritize 464 organic chemicals of emerging Arctic concern for their potential to fit a set of four exposure-based hazard profiles. These four profiles represent persistent organic pollutants (POPs) regulated under the Stockholm Convention, very persistent and very bioaccumulative substances (vPvBs) regulated under REACH and for two novel and unregulated profiles derived from the planetary boundary threats framework; airborne persistent contaminants (APCs) and waterborne persistent contaminants (WPCs). APCs and WPCs are chemicals that are mobile in air and water, respectively, and that contaminate the environment in a poorly reversible manner due to their persistence. The prioritization method is based on a reference set of 148 chemicals that is used to contextualize the scoring results.  Paper III describes the prioritization of 8,648 chemicals that were reportedly produced in five OECD countries. Paper III elucidates the relationship between the elemental composition of these chemicals and the exposure-based hazard scores, and presents a strategy to disentangle overlaps among the four exposure hazard profiles by categorizing chemicals according to the spatial coverage of profiles they best fit.  Paper IV focuses on refining the prioritization method described in Papers II and III using a set of 5,600 hypothetical chemicals. The refined method is used to prioritize the chemicals from Papers II and III, and an additional 4,567 chemicals from the REACH database.  The in silico methods developed in this thesis can be applied to conduct screening-level exposure assessments using only chemical structures as a starting point. Substances prioritized as having high potential to be POPs, vPvB, APC, or WPC should be considered for more detailed study to unequivocally determine their identity and physicochemical properties. / <p>At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 3: Manuscript. Paper 4: Manuscript.</p>