I Europa kan omkring 20 miljoner människor vara exponerade för dricksvatten som innehåller evighetskemikalien PFAS. Tidigare har försök att begränsa enskilda PFAS-ämnen endast resulterat i att det förbjudna ämnet i fråga har bytts ut till ett annat PFAS-ämne. Den europeiska kemikaliemyndigheten (ECHA) har utfärdat rapporten Annex XV Restriction Report, Per- and polyfluoroalkyl substances (PFASs) där två förslag om hur begränsningen av PFAS-ämnena kan utformas har introducerats. Rapporten presenterar möjligheten att utfärda ett generellt förbud av alla PFAS-ämnen. Om beslutet om en generell begränsning fattas i den Europeiska unionen (EU) kan det bli ett av de största förbuden någonsin mot kemiska ämnen i Europa. Arbetets syfte är att utreda huruvida de presenterade förslagen för hur PFAS ska begränsas i begränsningsrapporten är ändamålsenligt utformade utifrån konceptet av effektorienterad lagstiftning. Begränsningsförslagen analyseras med hjälp av miljörättsvetenskaplig metod och ställs i relation till begreppet hållbar utveckling. Att undersöka om begränsningsförslagen är ändamålsenligt utformade är särskilt intressant, eftersom ett beslut som begränsar PFAS-användningen enligt de presenterade förslagen skulle påverka såväl EU:s ekonomi som ekologi. Om ett juridiskt beslut fattas, måste det vara väl avvägt och nå önskad effekt, särskilt när det påverkar hela EU. I uppsatsen utreds vidare vilket begränsningsförslag som bäst tillgodoser behovet av god dricksvattenkvalitet och människors hälsa, samt hurbegränsningsförslagen förhåller sig till en hållbar utveckling. Efter en analys av begränsningsrapporten dras slutsatsen att båda begränsningsförslagen är ändamålsenligt utformade utifrån effektorienterad lagstiftning. Begränsningsförslagen är utformade så att de riktar begränsningar mot aktörer (människor) för att motverka att deras agerande har negativ inverkan på reaktörer (naturen och miljön). Begränsningsförslagen är dock olika orienterade. Begränsningsförslag två är mer aktörsorienterat än begränsningsförslag ett, eftersom begränsningsförslag två tar en större hänsyn till industrisektorns intressen. Båda begränsningsförslagen har ändå en starkt reaktörsfokuserad karaktär, eftersom de hindrar PFAS-användning från att förorena miljön. Ohållbar miljöpåverkan till följd av användning av PFAS kan motiveras i vissa fall, om det tillgodoser allmänna intressen eller är nödvändigt av lagtekniska skäl. Vidare dras slutsatsen att det begränsningsförslag som bäst tillgodoser behovet av goddricksvattenkvalitet är begränsningsförslag ett. Behovet av god hälsa bör kunna tillgodoses bäst genom begränsningsförslag ett för den största gruppen människor, eftersom detbegränsningsförslaget inte tillåter några undantag från PFAS-förbudet. Ett begränsningsförslagsom inte tillåter undantag möjliggör för en mindre mängd PFAS-exponering. Den gruppmänniskor i EU som är i behov av PFAS i medicinskt syfte kan dock dra nytta av att begränsningsförslag två tillåter användningsspecifika undantag. Avslutningsvis dras slutsatsen att båda begränsnignsförslagen leder till en reduktion av PFAS-utsläpp samt PFAS-exponering och är således hållbara utifrån ekologisk hållbarhet. Utifrån ekonomisk hållbarhet bör begränsningsförslag två vara mest gynnsamt, eftersom det är mest troligt att tillåta en hanterbar omställning för de olika industrisektorerna. Utifrån sociala aspekter av hållbarhet såsom hälsa, välbefinnande och privatekonomi, bör begränsningsförslagett vara det mest gynnsamma begränsningsalternativet. Detta trots att begränsningsförslag två tillåter medicinsk användning av PFAS samt tar en större hänsyn till industrisektorns ekonomi,vilket påverkar enskildas privatekonomi.

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Cette thèse examine deux modèles alternatifs de prises de décision motrice à travers des données comportementales humaines et des données électrophysiologiques de singes obtenues lors d'une tâche de décision multi-attributs. Les théories psychologiques classiques suggèrent que la prise de décision soit une fonction de l'exécutif central (EC). En accord avec cela, de nombreuses études ont montré des modulations neuronales concernant les décisions dans le cortex préfrontal (PFC), renforçant la notion que les décisions sont prises à un niveau abstrait dans l'exécutif central du cerveau : le PFC. Cependant, de telles corrélations neuronales se trouvent également dans les régions sensorimotrices, qui étaient traditionnellement considérées externes à l’EC. Cela a conduit à un modèle alternatif de prise de décision dans un EC, impliquant plusieurs zones cérébrales, y compris les zones exécutives et sensorimotrices. Ce second modèle suggère qu'une décision est prise lorsque les compétitions au sein et entre les aires cérébrales arrivent à une résolution, ce qui permet d'atteindre un consensus distribué (CD). L'objectif principal de cette thèse est de tester les prédictions faites par ces deux modèles. Pour ce faire, nous avons conçu une tâche d'atteinte basée sur la valeur d'attributs multiples et créé une situation dans laquelle les deux modèles font des prédictions neuronales distinctes. Dans cette tâche, deux attributs visuels indépendants indiquaient le montant de la récompense associé à chaque cible. L'un était un degré de luminosité, information ascendante (BU pour "bottom-up"), ciblant le réseau de saillance par le biais de la voie visuelle dorsale. L'autre était un indice d'orientation de ligne, information descendante (TD pour "top-down"), ciblant le réseau de catégorisation basé sur la connaissance par le biais de la voie visuelle ventrale. Nous avons effectué des enregistrements dans la région d’atteinte pariétale (PRR) et le cortex pré-moteur dorsal (PMd) du singe, dont les activités neuronales ont été précédemment impliquées comme étant modulées par des attributs BU et TD similaires. Dans la plupart des essais, les deux attributs étaient congruents – tous les deux favorisant la même cible. Cependant, un sous-ensemble d'essais avait des cibles avec la même valeur de récompense totale, mais où les deux attributs étaient en conflit (les caractéristiques BU et TD favorisant des cibles opposées). Le modèle de l'EC prédit que dans ce cas, l’activité neuronale la plus précoce doit apparaître dans une région exécutive et que les régions sensorimotrices doivent recevoir la diffusion de cette décision. Ainsi, ce modèle prédit que la différence du temps de réaction entre le PRR et le PMd sera constante, quelle que soit la manière dont la décision est prise. En revanche, le modèle CD prédit que l’intervalle de décision doit refléter le rôle d'une région dans la décision en cours. Plus précisément, si PRR et PMd font tous deux parties du réseau de décision distribué et jouent un rôle dans l'évaluation des attributs BU et TD, un choix en faveur de l'attribut BU devrait apparaître d'abord dans le PRR et par la suite dans le PMd, tandis qu'un choix en faveur de l'attribut TD devrait apparaître dans l'ordre inverse. Notre étude démontre que le temps de réaction des participants humains était plus rapide dans les essais congruents et lors de l'utilisation de l'information BU par rapport à l'utilisation de l'information TD. La distribution ne reflétait pas linéairement la complexité de l'attribut et semblait plutôt suggérer une intégration incomplète des informations disponibles. Ainsi, le résultat n'était pas entièrement explicable par un modèle d'EC pur. Le temps de réaction des participants était également plus rapide lorsqu'ils choisissaient entre deux options de grande valeur par rapport aux options de faible valeur, ce qui suggère que la loi de Weber ne s'applique pas aux attributs visuels indiquant des informations de valeur. La distribution du temps de réaction de notre premier singe était similaire à celle des participants humains. Sur le plan neuronal, l’intervalle de décision du PMd était presque toujours plus rapide que celle du PRR et le PRR ne précédait jamais le PMd; aussi, la différence de l’intervalle de décision entre ces régions n'était pas constante. Le PMd a montré un biais de base pré-stimulus dans les essais de choix libre, alors que ce n’était pas le cas pour le PRR. La distribution de l’intervalle de décision dans le PMd variait également en fonction des conditions d'essai, tandis que celle du PRR ne distinguait que les cibles uniques des cibles multiples. Une tendance similaire a été observée dans les analyses préliminaires des potentiels de champ locaux (LFP). Enfin, les résultats préliminaires suggèrent des effets plus cohérents de la micro-stimulation dans le PMd que dans le PRR. Nos résultats soutiennent le rôle causal du PMd, mais pas celui du PRR. Nos résultats sont cohérents avec les rapports précédents sur l'activité neuronale liée au choix dans les régions pariétales, car l'activité du PRR reflétait le choix du singe dans notre tâche. Nos résultats sont également cohérents avec d'autres études montrant l'absence de preuves du rôle causal des régions pariétales dans la prise de décision, car l'ordre relatif de l'activité prédictive du choix dans le PRR et le PMd ne variait pas entre les différentes conditions. À la lumière de ces deux modèles, nos résultats suggèrent une troisième alternative, qui inclut potentiellement le PMd en tant que partie du réseau de décision, mais pas le PRR. / This thesis examines two alternative models of action decisions through human behavioural and monkey electrophysiological data obtained during a multi-attribute decision task. Classic psychological theories suggest that decision-making is a function of the Central Executive (CE). In line with this, many studies showed neural correlates of decision variables in the prefrontal cortex (PFC), strengthening the notion that decisions are made at an abstract level in the brain’s central executive: PFC. However, such neural correlates are also found in sensorimotor areas, which were traditionally considered outside the CE. This has led to an alternative model to the decision making in a CE, involving multiple brain areas including both executive and sensorimotor areas. This second model suggests that a decision is made when competitions within and across brain areas come to a resolution, thus a Distributed Consensus (DC) is achieved. The main objective of this thesis is to test the predictions made by these two models. To do so, we designed a multi-attribute value-based reaching task, and created a situation in which the two models made distinct neural predictions. In this task, two independent visual attributes indicated the amount of reward associated with each reach target. One was a “bottom-up” (BU) brightness, targeting the saliency network through the dorsal visual pathway. The other was a “top-down” (TD) line orientation cue, targeting the knowledge-based categorization network through the ventral visual pathway. We recorded from monkey parietal reach region (PRR) and dorsal premotor cortex (PMd), whose activities have previously been implied to be modulated by similar BU and TD attributes. In most trials, the two attributes were congruent – both favoring the same target. However, a subset of trials consisted of a conflict between the two attributes (BU and TD features favoring opposite targets), but the targets had the same total reward values. Here, the CE model predicted that the earliest choice-predictive activity should appear in an executive region, and sensorimotor regions were expected to be receiving this decision broadcast. Thus, the model predicted the latency difference between PRR and PMd to be constant, regardless of how the decision is made. In contrast, the DC model predicted choice latency should reflect a region’s role in the ongoing decision. Specifically, if both PRR and PMd are part of the distributed decision network and play a role in evaluating the BU and TD attributes, a choice in favor of the BU attribute should appear first in PRR and then in PMd, whereas a choice in favor of the TD attribute should appear in the opposite order. We report that human participants’ reaction time (RT) was faster in congruent trials and when using the BU information compared to when using the TD information. The RT distribution did not linearly reflect the attribute complexity, and instead suggested an incomplete integration of available information. Thus, the result was not fully explainable with a pure CE model. Their RT was also faster when choosing between two high-valued options compared to low-valued options, suggesting that Weber-Fechner law does not apply to visual attributes that indicate value. Our first monkey’s RT distribution was similar to that of human participants. Neurally, choice latency of PMd was almost always faster than that of PRR and PRR never preceded PMd, and the latency difference between these regions was not consistent. PMd showed a pre-stimulus baseline bias in free-choice trials, whereas PRR did not. The distribution of choice latency in PMd also varied with trial conditions, whereas that of PRR only discriminated single versus multiple targets. A similar trend was seen in preliminary analyses of local field potentials. Finally, preliminary results suggest more consistent effects of microstimulation in PMd than in PRR. Our results support the causal role of PMd, but do not support that of PRR. This is consistent with previous reports of choice-related neural activity in the parietal regions, as PRR activity did reflect the monkey’s choice in our task. Our results are also consistent with other studies showing the absence of evidence for parietal regions’ causal role in decision-making, as the relative order of choice-predictive activity in PRR and PMd did not vary between different conditions. In light of the two models, our results suggest a third alternative, which potentially includes PMd, but not PRR, as part of the decision network.

An ergonomically designed work environment may decrease work related musculoskeletal disorders, lead to less sick leaves and increase production time for operators and companies all around the world. Volvo Construction Equipment wants to deepen the knowledge and investigate more carefully how operators are actually sitting whilst operating the machines, how this affects placement of controls and furthermore optimize controls placements accordingly. The purpose is to enhance their product development process by suggesting guidelines for control placement with improved ergonomics based on operators’ sitting postures. The goal is to deliver a process which identifies and transfers sitting postures to RAMSIS and uses them for control placement recommendations in the cab and operator environments. Delimitations concerns: physical ergonomics, 80% usability of the resulted process on the machine types, and the level of detail for controls and their placements. Research, analysis, interviews, test driving of machines, video recordings of operators and the ergonomic software RAMSIS has served as base for analysis. The analysis led to (i) the conclusion that sitting postures affect optimal ergonomic placement of controls, though not ISO-standards, (ii) the conclusion that RAMSIS heavy truck postures does not seem to correspond to Volvo CE’s operators’ sitting postures and (iii) and to an advanced engineering project process suitable for all machine types and applicable in the product development process. The result can also be used for other machines than construction equipment. The resulted process consists of three independent sub-processes with step by step explanations and recommendations of; (i) what information that needs to be gathered, (ii) how to identify and transfer sitting postures into RAMSIS, (iii) how to use RAMSIS to create e design aid for recommended control placement. The thesis also contains additional enhancements to Volvo CE’s product development process with focus on ergonomics. A conclusion is that the use of motion capture could not be verified to work for Volvo Construction Equipment, though it was verified that if motion capture works, the process works. Another conclusion is that the suggested body landmarks not could be verified that they are all needed for this purpose except for those needed for control placement. Though they are based on previous sitting posture identification in vehicles and only those that also occur in RAMSIS are recommended, and therefore they can be used. This thesis also questions the most important parameters for interior vehicle design (hip- and eye locations) and suggests that shoulder locations are just as important. The thesis concluded five parameters for control categorization, and added seven categories in addition to those mentioned in the ISO-standards. Other contradictions and loopholes in the ISO-standards were identified, highlighted and discussed. Suggestions for improving the ergonomic analyses in RAMSIS can also be found in this report. More future research mentioned is more details on control placement as well as research regarding sitting postures are suggested. If the resulted process is delimited to concern upper body postures, other methods for posture identification may be used.

The meaning of loss is love. I know this through attention to experience. Whether loss or love is experienced in abundance or in absence, the meaning is mystical with an opening of body, mind, heart and soul to spirit. And so, in the style of a memoir, in the way of contemplative prayer, I contemplate and share my soul as a promise kept in the mystical reach through loss. With the first, initiating loss, the loss of my nine-year-old nephew, Caleb, I experience an epiphany that gives me spiritual instructions that will not be ignored. I experience loss as an abundance of meaning that comes to me as gnosis, as “knowledge of the heart” according to Elaine Pagels or divine revelation in what Evelyn Underhill calls mystical illumination in the experience of “losing-to-find” in union with the divine. Then, with gnostic import, in leaving the ordinary for the extraordinary, I enter the empty room in the painful yet liberating experience of the loss of my self. In the embrace of emptiness, I proceed to the first wall, the second wall, the third wall, the dark corner of denial, the return to centre, and, finally, to breaking the fourth wall in the empty room so as to keep my promise to you. Who are “you”? You are God. You are Caleb. You are spirit. You are my higher soul or self. And, you are the reader. You are my dear companion in silence. And then, through a series of broken promises and more loss, within what John of the Cross calls, “the dark night of the soul,” I am stopped by the ineffability of the dark corner of denial, the horror of separation and the absence of meaning, which is depicted as the grueling gap between the spiritual abyss and the breakthrough. What does it mean to keep going through a solemn succession of losses? I don’t know. In going into the empty room, I simply put pain to work in order to reach you. Through loss, though there are infinite manifestations, there is only one way: keep going. And so, in a triumph of the spirit, I keep going so as to be: a promise kept in the mystical reach through loss. As for you, through my illumined and dark experiences of loss, what is my promise to you? I keep going to reach the unreachable you. In the loss of self, with embodied emptiness, in going into the dark corner of denial, with a return to the divine centre of my emptied self, in an invitation to you, I give my soul to you in union with you. / Graduate / 2020-06-25

Made available in DSpace on 2011-05-04T12:36:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2009 / O objetivo desta dissertação consiste em investigar o processo de construção da identidade profissional de médicos que se dedicam à assistência a pacientes que apresentam doenças progressivas e ameaçadoras da continuidade existencial e que têm contribuído para o desenvolvimento dos Cuidados Paliativos no Brasil. Buscamos conhecer a trajetória profissional destes médicos desde a escolha da medicina como profissão até o encontro com a filosofia e a prática dos Cuidados Paliativos. Com este intuito, realizamos entrevistas semiestruturadas,colhidas segundo a metodologia de História Oral de Vida. Foram entrevistados seis médicos de diferentes especialidades que ocupam cargos diretivos em uma das associações profissionais voltadas para a disseminação e legitimação política e social dos Cuidados Paliativos no Brasil. Os depoentes se destacam no cenário nacional no que diz respeito às discussões sobre esta temática e mantêm contato com importantes instituições internacionais. Por esta razão, chamamos o conjunto de entrevistados de elite médica paliativista. Percebemos uma pobre interlocução entre os médicos paliativistas, o que se reflete na ausência de uma identidade integrada desse grupo profissional. Os entrevistados acentuaram as competências humanitárias necessárias ao bom exercício da Medicina Paliativa, mas, no entanto, não foram explicitadas as competências específicas a este campo profissional, que justificariam seu reconhecimento pelas entidades médicas competentes comouma nova área de atuação ou especialidade.

The design of cultural centre is situated in part Kozia Hôrka( well-known city swimming pool), in its advantage takes natural scenery and calm atmosphere of place. Into action of performance brings a message in form of body of reservoir, function of centre is divided into small parts placed in area Kozia Hôrka. Orientation of objects comes mainly from local natural ispirations. Complex is multifunctional in concept, counts with several sorts of culture - sports events. Whereby the main function of swimming pool is preserved and added for higher comfort of inhabitants. Architecture of objects comes from idea of floating leaf on water level and body of reservoir. Objects stylizely illustrate this idea. The design takes the game of solids of organic and strictly ortogonal shapes. Two mutual opposites, in interaction. Objects smoothy and with respect encroach the environment, which is enough marked by human. Simplicity in used materials ( glass, steel, wood ) give transparency and purity to whole solution.

Submitted by Johnny Rodrigues (johnnyrodrigues@ufcg.edu.br) on 2018-08-01T21:11:37Z No. of bitstreams: 1 REX ANTONIO DA COSTA MEDEIROS - TESE PPGEE 2008..pdf: 1089371 bytes, checksum: ea0c95501b938e0d466779a06faaa4f6 (MD5) / Made available in DSpace on 2018-08-01T21:11:37Z (GMT). No. of bitstreams: 1 REX ANTONIO DA COSTA MEDEIROS - TESE PPGEE 2008..pdf: 1089371 bytes, checksum: ea0c95501b938e0d466779a06faaa4f6 (MD5) Previous issue date: 2008-05-09 / Nesta tese, a capacidade erro-zero de canais discretos sem memória é generalizada para canais quânticos. Uma nova capacidade para a transmissão de informação clássica através de canais quânticos é proposta. A capacidade erro-zero de canais quânticos (CEZQ) é definida como sendo a máxima quantidade de informação por uso do canal que pode ser enviada através de um canal quântico ruidoso, considerando uma probabilidade de erro igual a zero. O protocolo de comunicação restringe palavras-código a produtos tensoriais de estados quânticos de entrada, enquanto que medições coletivas entre várias saídas do canal são permitidas. Portanto, o protocolo empregado é similar ao protocolo de Holevo-Schumacher-Westmoreland. O problema de encontrar a CEZQ é reformulado usando elementos da teoria de grafos. Esta definição equivalente é usada para demonstrar propriedades de famílias de estados quânticos e medições que atingem a CEZQ. É mostrado que a capacidade de um canal quântico num espaço de Hilbert de dimensão d pode sempre ser alcançada usando famílias compostas de, no máximo,d estados puros. Com relação às medições, demonstra-se que medições coletivas de von Neumann são necessárias e suficientes para alcançar a capacidade. É discutido se a CEZQ é uma generalização não trivial da capacidade erro-zero clássica. O termo não trivial refere-se a existência de canais quânticos para os quais a CEZQ só pode ser alcançada através de famílias de estados quânticos não-ortogonais e usando códigos de comprimento maior ou igual a dois. É investigada a CEZQ de alguns canais quânticos. É mostrado que o problema de calcular a CEZQ de canais clássicos-quânticos é puramente clássico. Em particular, é exibido um canal quântico para o qual conjectura-se que a CEZQ só pode ser alcançada usando uma família de estados quânticos não-ortogonais. Se a conjectura é verdadeira, é possível calcular o valor exato da capacidade e construir um código de bloco quântico que alcança a capacidade. Finalmente, é demonstrado que a CEZQ é limitada superiormente pela capacidade de Holevo-Schumacher-Westmoreland.