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Bakgrund: Parkinsons sjukdom är en obotlig sjukdom som ofta drabbar personer i 50–60 års ålder. Sjukdomen finns ofta hos patienten långt innan diagnosen ställs och innebär en livsomställning med både fysiska och psykiska förändringar. I och med att sjukdomen är progreserande försämras livskvalitén ju längre patienten haft sjukdomen. Syfte: Syftet äratt beskriva hur människor med Parkinsons sjukdom upplever sin livssituation. Metod: Enkvalitativ studie som bygger på analys av fem självbiografier skrivna av personer som har drabbats av Parkinsons sjukdom utifrån metoden Att analysera berättelser. Resultat: De drabbade upplever en förändring i sitt liv och sin vardag efter att de diagnostiserats medParkinsons sjukdom. Men trots de utmaningar och svårigheter som upplevs finns en vilja om att fortsätta leva och ta tillvara på tiden. Personerna upplever även en vilja att kämpa för att bibehålla sina fysiska och psykiska funktioner och genom detta bibehålla en god livskvalitet. Konklusion: Personer som drabbas av Parkinsons sjukdom upplever en livsförändring. Men med en positiv livsinställning, stöd från anhöriga, andra personer som lider av Parkinsons sjukdom och sjuksköterska kan de drabbade uppleva en god hälsa trots sjukdomen. Sjuksköterskans kunnighet kring sjukdomen, förmåga att lyssna och sätta sig in i patientens livssituation är viktiga delar för en god vård. / Background: Parkinson's disease (PD) is an incurable disease that often begins to affect people in their 50s and 60s. Patients can have different symptoms several years before the diagnosis which affect their well-being. Diagnosis with PD means that a person’s life condition changes both physically and mentally. The patient’s quality of life is seriously affected and gets worse as the time passed due to the disease being progressive. Aim: The aim of the study is to describe how people with Parkinson's disease experience their life.Method: The study is based on a qualitative method “att analysera berättelser” and the data analysis is based on five autobiographies which were written by people suffering from PD. Results: It appears that patients who are living with PD experience a changed ife perspective and situation. Despite the challenges and difficulties in life, there is a willing to continue their life as well as possible and enjoy living in the moment. People also experience a willingness to try to maintain their physical and mental functions and thereby maintain a good quality of life. Conclusion: People who suffers from PD experience a life-changing situation. With a positive attitude and support from relatives and nurses, patients can still experience well-being and have a good quality of life. The nurse's knowledge of PD, ability to listen and understand the patient's life situation are important elements for providing a good care.

Karlström, P & Mårtensson, L. Sjukdomen Parkinson och livskvalitet. En kvalitativ studie utifrån Parkinsonsjuka personers upplevelser av livskvalitet. Examensarbete i omvårdnad 15 högskolepoäng. Malmö Högskola: Fakulteten för Hälsa och Samhälle, Utbildningsområde omvårdnad, 2016. Parkinsons sjukdom är en kronisk progressiv neurologiskt sjukdom. Orsaken till sjukdomen är okänd. Årligen insjuknar omkring 2000 personer i Sverige. Prevalensen i Sverige uppskattas till 20 000 fall. Medelåldern vid symtomdebut är 55 år. De tre kardinalsymtomen är rörelsehämning, skakning och muskelstelhet. Ofta finns också psykiska symtom så som depression, ångest och initiativlöshet. Parkinsons sjukdom påverkar den drabbade personens dagliga liv och livskvalitet.Syftet med studien var att undersöka hur vuxna personer som lever med Parkinsons sjukdom upplevde sitt dagliga liv samt deras beskrivning av hur livskvaliteten påverkades. Metoden var en litteraturstudie för att sammanställa tidigare vetenskaplig forskning av kvalitativ ansats. Databasökning utfördes i tre olika databaser. De aktuella artiklarna värderades kritisk utifrån granskningsprotokoll. Resultatet baserades på tio kvalitativa artiklar. Slutresultatet delades in fyra huvudkategorier med underkategorier där fynden presenteras. Huvudkategorierna var Relationer och social samvaro, Hälsa och ohälsa, Kroppsliga förändringar samt Leva vidare trots sjukdomen Parkinson. Konklusion är att Parkinsons sjukdom är en komplicerad sjukdom som påverkar patientens liv och livskvalitet. Nyckelord: Acceptans, , Framtid, Livskvalitet, Parkinsons sjukdom och Socialt, Välmående / Karlström, P & Mårtensson, L. Parkinson`s Disease and Quality of Life - An qualitative literature review from the perspective of the patients with Parkinson`s Disease about Quality of life. A literature review. Degree project in Nursing science, 15 Credit Points. Malmö University. Faculty of Health and Society. Department of Caring Science, 2016.Parkinson`s Disease is a progressive neurological disease. The cause of the disease is still unknown. In Sweden, there are 2000 new sufferers each year. The prevalence in Sweden is about 20 000. The average age due to the first symtoms appearing, is 55 years old. The three main symtoms are: akinesia, shakiness and muscle stifness. The disease also includes symtoms as depression, anxiety and apathy. Parkinson`s Disease has an effect on many aspects of life. The aim of the study was to examine how grown adults experienced their daily life and how they described the Quality of life changing. The method was a literature review using qualitative data. Data was gathered from three different databases. The material was then critically evaluated using a qualityprotocall.The results were gathered from ten different articles. Four main qualitative categories were found: Relations and socializing and Health and ill-health, body changes and Live on despite having Parkinson`s Disease. The main categories were later on further divided into subcategories. Conclusions that was drawn explained that Parkinson`s disease is a complicated disease envolving many aspects of the patients life which contributes to the experience of Ouality of life. Keywords: Acceptance, Future, Parkinson`s Disease and Socially wellbeing. Quality of life.

Background: Parkinson's disease [PD] is increasing more than any other neurological disease worldwide. PD is a multifactorial neurodegenerative disease with progressive impairment of motor control. Those affected by PD need an individual assessment regarding the care, rehabilitation and aids. Relatives are seen as a resource and carers can spend up to 110 hours a week caring for their relatives with PD. Aim: The aim was to investigate how elderly people with Parkinson's disease experience their care at home and how carers are affected. Method: The study is a literature review where previous knowledge is compiled into an overview. The literature review includes both qualitative and quantitative articles that where searched and selected from the databases Pubmed and Cinahl.  Results: Two major themes emerged: Aging with PS in the ordinary home and the impact of support in everyday life. The participants expressed the value of support, communication and care from health organisations, relatives and other PD-effected people.  Conclusion: The results showed that access to good healthcare and support was a decisive factor to be able to continue to live as normal as possible in the ordinary housing. Most family carers needed support from formal caregivers to cope. Information and education about Parkinson's pathophysiology and emotional support had a major impact to be able to plan the future and to be able to cope with the disease. / Att åldras medför förändringar och nya anpassningar i vardagen både för den äldre och de anhöriga. Att samtidigt drabbas av Parkinsons sjukdom (PS) medför ytterligare utmaningar och många som drabbas av sjukdomen upplever en livskris. Många av de som drabbas av sjukdomen och deras anhöriga har en önskan om att den drabbade ska kunna fortsätta bo kvar i det ordinära boendet och för att detta skall vara möjligt krävs rätt stöd och hjälpmedel för att vardagen skall kunna fungera på ett liknande sätt som tidigare. Denna litteraturöversikt undersöker hur personer som är äldre och har drabbats av PS upplevervården i det ordinära boendet samt hur anhörigvårdarna påverkas. I resultatet framkom vikten av stöd i hemmet för att skapa en fungerande vardag, både socialt och praktiskt. Sjuksköterskan har en avgörande roll för de som vårdas i det ordinära boendet även om de har en anhörigvårdare. Emotionellt stöd, kunskap om sjukdomens patofysiologi, de formella vårdgivarnas kunskaper och anhörigvårdarnas möjlighet till avlastning är viktiga delar som studien kom fram till. PS är en multifaktoriell neurodegenerativ sjukdom med progressiv försämring av motorisk kontroll. Att vara anhörig till en som drabbats av PS kan upplevas frustrerande eftersom den framtida prognosen inte är självklar och framtiden upplevs som oviss. Sjuksköterskan blir därför en bra resurs och informationskälla för medicinska- och patofysiologiska kunskaper hos båda parter. I diskussionen framkom det att vardagen förändrades markant för de som blir involverade i sjukdomen när någon drabbas. Sjukdomen uttrycker sig på olika sätt hos de drabbade och många av de vardagliga aktiviteterna behöver anpassas efter den PS-drabbades enskilda förmåga. Stöd i vardagen och utbildning om sjukdomens patofysiologi var viktiga grundstenar för att få en fungerande vardag. Studiens metod var litteraturöversikt där både kvalitativa- och kvantitativa artiklar har använts. Resultatet består av tio artiklar som analyserats och kodats enligt Friberg (2017). De valda artiklarna till resultatet kom ifrån sju olika länder vilket ökar överförbarheten då det kan leda till internationell kunskap.

[pt] A Doença de Parkinson (DP) é caracterizada pela ocorrência de sintomas motores. No entanto, sintomas não motores, como depressão e comprometimento cognitivo, são comuns e não devem ser ignorados. A presente dissertação investigou a frequência dos sintomas depressivos e seus efeitos na cognição de indivíduos com DP com declínio cognitivo leve (DCL). Foram avaliados 48 sujeitos com DP e 44 controles (GC), com idade entre 50 e 80 anos e escolaridade superior a 4 anos, todos com DCL e sem diagnóstico de depressão. Os participantes foram submetidos à avaliação clínica com neurologista, seguida de avaliação neuropsicológica. Os sintomas depressivos foram mensurados com o uso do Inventário de Depressão de Beck. Dificuldade no trabalho, fadiga e distúrbio do sono foram sintomas mais frequentes no grupo DP, enquanto o grupo sem DP apresentou além de distúrbios do sono, sintomas de irritabilidade e diminuição da libido. A presença destes sintomas mostrou-se associada a prejuízo da atenção combinado a déficit de memória episódica, especialmente em tarefas de reconhecimento de novas informações verbais. Os sintomas depressivos prevalentes nos Parkinsonianos com DCL podem ser atribuídos à DP, dificultando o diagnóstico diferencial entre essas condições. / [en] Parkinson s Disease (PD) is characterized by the occurrence of motor symptoms. However, non motor symptoms such as depression and cognitive impairment are common and should not be ignored. This thesis investigated the frequency of depressive symptoms and their effect on cognition in individuals with PD with mild cognitive impairment (MCI). Forty eight subjects with PD and 44 controls (CG), aged between 50 and 80 years and higher education to four years, all with MCI and undiagnosed depression were studied. The participants underwent clinical evaluation with a neurologist, followed by neuropsychological assessment. Depressive symptoms were measured using the Beck Depression Inventory. Difficulty in work, fatigue and sleep disorders were more frequent symptoms in PD group, whereas the group without PD presented beyond sleep disorders, symptoms of irritability, and decreased libido. The presence of these symptoms was found to be associated with loss of attention combined to episodic memory deficits, especially in recognition tasks of new verbal information. The prevalent depressive symptoms in parkinsonians with MCI can be attributed to PD, complicating the differential diagnosis between these conditions.

Accurate Detection of Parkinson`s Disease in Tremor Syndromes Using Olfactory Testing

A doença de Parkinson (DP) é uma desordem neurodegenerativa caracterizada clinicamente por tremor, rigidez, acinesia (ou bradicinesia) e instabilidade postural. Patofisiologicamente, a DP é classificada como uma sinucleinopatia associada à perda de neurônios dopaminérgicos na substância negra (SN), mas outros neurônios do tronco encefálico podem estar degenerados na DP, contribuindo não só para as alterações motoras, mas também não motoras observadas. Dentre as alterações não motoras, as alterações respiratórias estão presentes tais como obstrução das vias aéreas superiores, pneumonia e ainda a apnéia obstrutiva do sono uma das principais causas de morte na DP. Os mecanismos que levam à degeneração de neurônios envolvidos no controle respiratório ainda não estão bem esclarecidos, mas dados recentes do nosso laboratório mostraram que no modelo de DP induzido pela injeção no caudado-putâmen (CPu) de 6-hidroxidopamina (6-OHDA), um agente neurotóxico seletivo para células catecolaminérgicas, observou-se intensa redução na frequência respiratória e ventilação basais e induzidas pela ativação do quimiorreflexo central por hipercapnia. Além disso, observou-se também intensa redução do número de neurônios bulbares envolvidos no controle neural da respiração, como os neurônios Phox2b+ da região do núcleo retrotrapezóide (RTN), que estão envolvidos com a inspiração e o quimiorreflexo central. Dessa forma, o objetivo do presente trabalho foi investigar se a existência de uma via entre os neurônios da SN e do RTN poderia ser responsável por essa neurodegeneração. Realizamos injeções de traçadores anterógrados e retrógrados na SN e no RTN de ratos para verificar a existência de projeções diretas entre essas regiões, entretanto observamos que não há projeções diretas entre a SN e o RTN, mas há projeções indiretas entre essas duas regiões, utilizando a Substância Cinzenta Periaquedutal (PAG) como região intermediária. Além disso, observamos que no modelo de DP induzido pela injeção bilateral de 6-OHDA no CPu ocorre uma redução no número de varicosidades catecolaminérgicas na PAG e de neurônios que são ativados pelo quimiorreflexo central que se projetam da PAG para o RTN. Nossos experimentos eletrofisiológicos mostraram que a inibição bilateral da PAG pela injeção de muscimol não gera alterações respiratórias basais como ocorre no modelo da DP; entretanto, nesses animais, pudemos também observar, apesar de ser menor do que ocorre com animais submetidos ao modelo da DP, inibição de alterações respiratórias induzidas por hipercapnia. Nossos dados anatômicos mostraram que a comunicação entre os neurônios da SN e do RTN envolve neurônios da PAG e que essa via pode estar reduzida no modelo da DP, o que pode contribuir para a redução de neurônios do RTN; e que a redução neuronal desta via pode alterar as respostas respiratórias frente à ativação do quimiorreflexo central. / Parkinson\'s disease (PD) is a neurodegenerative disorder characterized clinically by tremor, rigidity, akinesia (or bradykinesia) and postural instability. Pathophysiologically, PD is classified as a synucleinopathy predominantly associated with loss of dopaminergic neurons in the substantia nigra (SN), but other brainstem neurons may also be degenerate in PD, contributing not only to the motor but also non-motor alterations observed in this pathology. Among the non-motor changes observed respiratory changes are present and can be characterized as upper airway obstruction, pneumonia and obstructive sleep apnea are one of the main causes of death in PD. The mechanisms that lead to the degeneration of neurons involved in respiratory control are still not well understood but data in the literature have demonstrated the loss of receptors in a region considered to be the respiratory rate generator in postmortem brains of humans. In the model animal DP of 6-hydroxydopamine (6-OHDA), a selective neurotoxic agent for catecholaminergic cells, there was an intense reduction in basal respiratory rate and ventilation, in addition to a intense reduction of neurons involved in neural control of breathing: Phox2b+ neurons in the retrotrapezoid nucleus (RTN) region. Thus, the aim of the present study was to investigate whether the existence of a pathway between SN and RTN neurons could be responsible for this bulbar neurodegeneration. We performed experiments using the injection of anterograde and retrograde tracers in the SN and the RTN to verify the existence of direct projections between these regions in rats. However, our results showed that there are no direct projections between the SN and the RTN, but there are indirect projections between these two regions, using Periaquedutal Gray Substance (PAG) as the intermediate region. In addition, we observed that in the PD model induced by the bilateral injection of 6-OHDA in CPu, a reduction of the projections PAG neurons for RTN and that are activated by the central chemoreflex. Our electrophysiological experiments have shown that in the 6-OHDA PD model there is a reduction of the cardiorespiratory responses induced by the activation of the central chemoreflex, since the bilateral inhibition of the PG of control animals does not alter these cardiorespiratory responses. Therefore, our anatomical results showed that the communication between SN and RTN neurons involves PAG neurons and that this pathway may be reduced in the PD model, which may contribute to the reduction of RTN neurons; and that the neuronal reduction of this pathway may alter respiratory responses to activation of the central chemoreflex.

A Doença de Parkinson (DP) é um distúrbio neurodegenerativo. Suas características e seus sintomas neuropatológicos são bem definidos, mas sua etiologia ainda continua desconhecida. A DP esporádica é caracterizada anatomo-patologicamente pela presença de Corpos de Lewy, que são agregados lipoproteicos que se encontram no interior do neurônio. A <font face=\"Symbol\">a-sinucleína é uma proteína solúvel presente nos terminais pré-sinápticos de vários sistemas de transmissão. Evidências sugerem que esta proteína é um componente fundamental dos Corpos de Lewy localizados nos neurônios dopaminérgicos do sistema nigroestrital de pacientes portadores de DP. Postula-se que a <font face=\"Symbol\">a-sinucleína possui uma função fundamental na patogênese da DP, pois pode afetar a homeostase de neurônios dopaminérgicos, levando ao aumento da dopamina no citosol e consequente estresse oxidativo. O fator de transcrição nuclear kappa B (NF-<font face=\"Symbol\">kB) participa da regulação de respostas imunes, inflamatórias e morte celular. No sistema nervoso central este fator está presente em diversos tipos de células nervosas e seu papel é paradoxal, ora apontado como neurotóxico, ora como neuroprotetor. O NF<font face=\"Symbol\">kB pode ser estimulado por vários fatores entre eles neurotransmissores (por exemplo: dopamina e glutamato), estresse e proteína <font face=\"Symbol\">b-amilóide. Neste trabalho, pretendemos estudar as modificações moleculares nas células SH-SY5Y transduzidas com a <font face=\"Symbol\">a-sinucleína na sua forma selvagem (WT), mutante (A30P) e truncada (1-120) e tratadas com meio condicionado (CM) (proveniente do tratamento da glia com LPS) ou TNF. Analisamos a modulação da atividade do NF-<font face=\"Symbol\">kB, onde observamos o aumento da atividade quando as células foram tratadas com TNF mas não com CM. Ainda, observamos que ocorre diminuição da fosforilação da proteína MAPK42/44 durante o mesmo tratamento, e que esta diminuição pode estar ligada ao aumento da morte celular. / Parkinsons Disease (PD) is a neurodegenerative disease. The characteristics and symptoms are well defined; nevertheless its etiology remains unknown. The sporadic PD is characterized by the presence of Lewy Body (aggregate of proteins) inside the neurons. Alpha-synuclein is a soluble protein present in the pre synaptic terminal of neurons. Evidences suggest that this protein is a fundamental component of Lewy bodies localized in the dopaminergic neurons of PD patients. It is already known that alpha-synuclein has a fundamental role in pathogenesis of PD, because it can affect the homeostasis of dopaminergic neurons, leading to increase of dopamine in the cytosol and consequent oxidative stress. The nuclear transcription factor kB (NF-<font face=\"Symbol\">kB) regulates the immune, inflammatory and cell death responses. In the central nervous system, this factor is present in several types of cells and its role is paradoxal, since it can be neurotoxic or can be protective. The NF<font face=\"Symbol\">kB can be stimulated by several factors, including dopamine, glutamate, stress and <font face=\"Symbol\">b-amyloid protein. In this work, we observed the molecular modification in SH-SY5Y cells transduced with alpha-synuclein (wild-type, A30P and truncated 1-120) and treated with conditioned medium (CM) (from primary culture of glia treated with LPS) or TNF. We analyzed the modulation of NF-<font face=\"Symbol\">kB activity, in which was observed that the activity was increased when the cells were treated with TNF but not with CM. Moreover, we show that there is a decrease of MAPK42/44 phosphorilation during the treatment, and this decrease is linked to the increase of cell death of these cells overexpressing alpha-synulein.

Made available in DSpace on 2016-04-04T18:29:34Z (GMT). No. of bitstreams: 1 Glaucia Mitsuko Ataka.pdf: 3815598 bytes, checksum: db7202d040a89d7913489ce6649b23ca (MD5) Previous issue date: 2007-02-06 / Pontif?cia Universidade Cat?lica de Campinas / The study aimed at the evaluation of depression, alexithymia, quality of life and personality styles of people with idiopathic Parkinson s disease. The sample of 100 participants was integrated by 41% men and 59% women, from 38 to 90 years old, aged from 50 to 79 years old (Mo=75 and 77 years old); 72,45% are pensioners; 68% are originally from Sao Paulo State; 53% with schooling from 8 years or more. The majority of the participants (59%) had the disease for 6 years and was classified as the 2nd stage of Parkinson s disease (80% of them). Participants were evaluated according to the following instruments: Beck Depression Inventory (BDI), Toronto Alexithymia Scale (TAS), Parkinson's Disease Questionnaire (PDQ- 39) and Millon Inventory of Personality Styles (MIPS). The average score of BDI was 11,8 (SD= 7,4), summing up 47% of the people with light or moderate depression. Their common symptoms were lack of pleasure, irritation, insomnia, fatigue, lack of interest in sex, concern with health and with the impossibility of working. Most of the people were scored as alexithymic (59%). Quality of life scores had an average total of 27,34 (SD=14,29). The highest scores were physical discomfort (M=32,4, SD=23,7); activities of daily living (M=31,8, DP=20,4) and mobility (M=31,0, DP=22,5). As for personality styles, 80% and more present strong characteristics called opennesss, protection, sensation, introversion, reflection, affectivity, systematization and firmness. The structure equation modeling (SEM), analyzed through Partial Least Square (PLS), showed that depression contributes significantly to quality of life, alexithymia and the dimensions of cognitive and interpersonal behaviors (evaluated by MIPS). Results were discussed considering the multidetermination of depression in Parkinson s disease and the importance of the intervention in depression focusing the improvement of quality of life. A heuristic proposal involves the theoretical model about a multidetermination of the depression in the illness as a model obtained in this study following PLS. The limitations imposed by the homogeneity of some characteristics of the sample are discussed and new studies are suggested, including samples with different characteristics and on psychotherapy interventions that consider psychological disorders and the positive aspects (adaptive resources) identified in this research. / O objetivo foi avaliar a associa??o entre depress?o, alexitimia, qualidade de vida e estilos de personalidade de pessoas com Doen?a de Parkinson, atendidos na Associa??o Brasil- Parkinson. A amostra, de 100 participantes diagnosticados com Doen?a de Parkinson idiop?tica, ficou composta por 59% de homens e 41% de mulheres, com idades entre 38 e 90 anos, concentradas nas faixas et?rias entre 50 e 79 anos (Mo= 75 e 77 anos). A maioria ? aposentada (72,45%) e natural de S?o Paulo (68%), com escolaridade de 8 anos ou mais (53%). O tempo de curso da doen?a concentrou-se em at? 6 anos (59%) e a maioria encontra- se no Est?gio II da doen?a (80%). Os instrumentos de auto-relato utilizados foram a Escala de Depress?o de Beck (BDI), Escala de Alexitimia de Toronto (TAS), Parkinson s Disease Questionnaire (PDQ-39) e Invent?rio de Estilos de Personalidade de Millon (MIPS), aplicados individualmente. O escore m?dio do BDI foi de 11,8 (DP=7,4), tendo sido 47% das pessoas classificadas com depress?o leve ou moderada. Os sintomas de depress?o mais referidos foram: falta de prazer, irrita??o, dificuldade com o sono, cansa?o, falta de interesse em sexo, preocupa??o com a sa?de e preocupa??o em n?o poder trabalhar. A maioria das pessoas foi classificada como alexit?mica (59%). Quanto ? qualidade de vida, o escore total m?dio foi de 27,34 (DP=14,29), sendo que as dimens?es com escores mais altos foram desconforto corporal (M=32,4, DP=23,7); atividades da vida di?ria (M= 31,8, DP= 20,4) e mobilidade (M= 31,0, DP=22,5). Quanto ao estilo de personalidade, 80% ou mais da amostra apresentou como caracter?sticas fortes: abertura, prote??o, sensa??o, introvers?o, reflex?o, afetividade, sistematiza??o e firmeza. O modelo de equa??es estruturais (SEM), analisado atrav?s do Partial Least Square (PLS) apresentou a depress?o como a vari?vel preditora da qualidade de vida, da alexitimia e das dimens?es modos cognitivos e condutas interpessoais (estas avaliadas pelo MIPS). Os resultados foram discutidos considerando a multidetermina??o da depress?o na Doen?a de Parkinson e a import?ncia da interven??o sobre a depress?o com o objetivo de melhorar a qualidade de vida. ? proposta uma heur?stica para a compreens?o da multidetermina??o da Doen?a de Parkinson e do modelo obtido pela aplica??o do PLS. S?o discutidas as limita??es impostas pela homogeneidade de algumas caracteristicas apresentadas pela amostra e sugeridos novos estudos em amostras com caracter?sticas diferentes e sobre interven??es psicoterap?uticas que considerem tanto os dist?rbios psicol?gicos quanto os aspectos positivos (recursos adaptativos) identificados no presente estudo.

Nosso trabalho foi dividido em um primeiro capítulo dedicado à análise do peptidoma do estriado de camundongos no modelo da 6-OHDA e também à atividade das oligopeptidases EP 24.15 e EP 24.16; e um segundo capítulo com os dados referentes a uma colaboração resultante de estágio sanduíche no Instituto Max-Planck de Psiquiatria em Munique, Alemanha, e que se refere a estudos peptidômicos em amostras post-mortem do lobo temporal anterior e do corpo caloso de pacientes esquizofrênicos. Para desenvolver os trabalhos utilizamos a técnica de marcação isotópica e label free aplicadas ao LC-MS/MS. No caso do modelo de Parkinson, os resultados indicaram alterações significativas em 5 diferentes fragmentos peptídicos e para a esquizofrenia, 2 fragmentos mostraram-se biologicamente diferentes. Ambos os trabalhos geraram grande quantidade de dados que abrem possibilidades investigativas para novos alvos de estudos em ambas as doenças. / The thesis is divided in one chapter, which was dedicated to peptidomic analysis of the striatum in the 6-OHDA mice model and also to oligopeptidase activity such as EP 24.15 and EP 24.16. The second chapter refers to data obtained during a research internship in the Max-Planck Institute of Psychiatry, Munich, Germany, in which we ran peptidomic analysis of post-mortem samples of the anterior temporal lobe and corpus callosum from schizophrenia patients. Both projects used mass spectrometry techniques such as isotopic labeling and label free applied to LC-MS/MS. In the Parkinsons disease model we observed significant changes in 5 different peptide fragments, and for schizophrenia samples, 2 peptide fragments were biologically different. The resulting data acquired in both projects lead to a substantial increase in prospective possibilities to new targets associated to the disorders studied here.