L’objet de cette recherche revient à interroger le rôle du hasard dans le processus d’individuation tel qu’il est théorisé par Gilbert Simondon. Dans cette perspective, le hasard, élaboré à partir du concept darwinien de chance, doit être considéré comme opérateur théorique et concept explicatif d’une théorie des processus de genèse de forme individuelle, et non comme un principe métaphysique ou une mesure de l’ignorance. Il qualifie dans l’individuation la modalité de la rencontre entre la singularité, qui donne forme à l’être individuel, et le milieu métastable individuel, susceptible de transformations. Suivant cette perspective, le hasard devient un des opérateurs de l’invention des structures individuelles singulières, plurielles, et novatrices, formes de vie et manières d’exister, qui sont élaborées comme solution à des problèmes par le processus d’individuation. Cette analyse de la pensée simondonienne va permettre de mettre en place les linéaments d’une théorie de la rencontre individuante, induisant une conception particulière de l’individualité humaine, qui est susceptible d’entrer en dialogue avec les thèses de la sociologie dispositionnelle (P. Bourdieu, B. Lahire). Comme invention, l’opération d’individuation sera alors analysable à partir du concept biologique d’exaptation (S. J. Gould), qui explicite dans l’évolution l’invention de couples structuro-fonctionnels nouveaux, à partir d’un jeu entre hasard et invention vitale. / This research aims to question the role of chance in the individuation process as it was theorized by Gilbert Simondon. In this context, chance, which was drawn up based on the Darwinian concept of chance, must be considered as a theoretical operator and as an explanatory concept of the genesis of individual form, and not as a metaphysical principle or as a measure of ignorance. It characterises within the individuation the modality of the encounter between the singularity which shapes the individual being and the individual metastable environment which is capable of being transformed. From this point of view, chance turns out to be one of the invention operators of singular, individual, plural and innovative structures which are ways of existing, created as solutions to problems by the individuation process itself. This analysis of Simondon’s philosophy allows us to outline a theory of the individuating encounter leading us to think of human individuality through a specific approach which enters into dialogue with the theses of the dispositional sociology (P. Bourdieu, B. Lahire). From an invention point of view, the individuation operation can thus be analysed using the biological concept of exaptation (S. J. Gould) which makes very explicit the invention of new structure-function couples in evolution based on an articulation between chance and vital invention.

The Munich analogy has been one of the most influential paradigms, which framed the United States strategic thinking in terms of use of force since 1945. The 1930s negative experience of appeasement traditionally served as a vehicle of rationalizing open and covert interventions, which allegedly aimed to stop the repetition of World War II scenario. The application of the historical reasoning in the US-Latin American relations since the 1950s contributed to the creation of the Munich syndrome in US foreign policy. This perception of threats led the American leaders to believe that the political changes in Latin America represented a serious challenge to the national security of the US. This study examines the role of Munich analogy and its relevance in justifying the policies of regime change in four Latin American countries namely Chile the Dominican Republic Grenada and Nicaragua. Due to the historical analogy contribution the indigenous political conflicts within these states were incorporated into dynamic Latin American Cold War. Based on the new available official documents and declassified files this paper offers a new perspective on the significant period of the 20th century international relations, whose consequences can be traced even in the contemporary US politics.

[pt] O presente trabalho se propõe a desenvolver um modelo de aprendizado do consumidor que contemple as dimensões do aprendente, do processo de aprendizagem e dos resultados obtidos neste aprendizado como melhor forma de entender e gerenciar estes consumidores. Para tal conduziu-se uma revisão bibliográfica e seguindo uma perspectiva interdisciplinar e multidisciplinar, recorreu-se às disciplinas de pedagogia, psicologia e marketing para formular tal modelo. Para avaliar o modelo multidisciplinar de aprendizagem, foi desenvolvida uma ferramenta em ambiente de internet que pudesse avaliar de maneira consistente e objetiva, todas as variáveis do modelo. Como resultado surgiram proposições que foram avaliadas em entrevistas com especialistas e correlacionadas a literatura existente. É objetivo deste trabalho entender melhor estes usuários, quer sejam consumidores de e- commerce ou não e poder melhor gerir o processo de aprendizado dos mesmos, algo novo e que terá impacto significativo no sucesso das organizações neste novo milênio. / [en] The purpose of the present dissertation is to develop a consumer learning model that involves multidimensional aspects, considering the learner, the process of learning and the result of learning. This model also should allow to understand and manage these consumers. In this sense, the literature review was provided and according to a standpoint which is both inter and multidisciplinary, contributions from several disciplines like Pedagogy, Psychology and Marketing oriented the construction of the model. In order to evaluate the multidimensional model, a tool was developed in internet environment, considering all variables of the model, consistently and objectively. As result, propositens were originated and evaluated by specialists, in qualitative interviews, and related to the literature review. As result of this dissertation, the better understanding of internet users, consumers or not, can be provided in order to manage their learning process, which is something new and can promote significant impact in organizational success in this new millennium.

Among the theoretical formulations about metaphors, it is important to remember that they are not linked only to language but also to human thought; the sociodiscursive and interactional context. Search this discursive phenomenon is to understand how work the processes of construction of sense of text / discourse; the relationships between people and culture. Thinking about this problem that involves different theoretical contributions, one notes the need for metaphor research in a vision that values the social, cognitive, cultural, interactional, the textual-discursive relations. The metaphor, while argumentative technique in Argumentation theory is built on the basis of Greek rhetoric, as the result of an analogy. In contrast, Perelman and Olbrechts-Tyteca (2005) conceptualize the metaphor as a condensed metaphor resulting from the fusion of a forum of the element with a theme element. This work, where metaphors are discursive calls to be present in their situational context reframing, aims to find out what is the role of this metaphor in the construction of gender in the application from the interweaving of narrative and Essay sequences. The initial application and receives a corpus analysis of cut: the narrative of the facts that is part of the greater power of discursive manipulation of confrontation in law of the operator with the other parties restricted to legislative regulation. Under the assumption that discursive metaphor results from the fusion between forum and topic. They analyze these elements by the bias condensed analogy of the interface with the theory of referencing the light of sociodiscursive-interactional perspective. Selected for analysis seven narratives of the facts of the application, which is focused on narrative and argumentative chaining built by outstanding metaphoric expression as forum; the perception of discursive elements of the theme; by interpretative discursivization of metaphoric expression with argumentative function. Therefore, we had as theoretical and methodological support studies developed by Perelman and Olbrechts-Tyteca (2005); van Dijk (2012); Mondada and Dubois (2003); Lakoff and Johnson (2002); Koch (2009) Marcuschi (2006), Koch (2003) Leite (2007). With it, it's possible to realize within the context that the analyzed metaphoric expressions have behind them a discursive content that puts a sociodiscursive and cognitive status. / Dentre as formulações teóricas acerca de metáforas, é importante lembrar que elas não estão ligadas somente à linguagem, mas também ao pensamento humano; ao contexto sociodiscursivo e interacional. Pesquisar esse fenômeno discursivo é entender de que forma funcionam os processos de construção dos sentidos do texto/discurso; as relações entre as pessoas e a cultura. Pensando nessa problemática que envolve diferentes aportes teóricos, é notória a necessidade de uma investigação da metáfora numa visão que valorize o social, o cognitivo, o cultural, o interacional, as relações textual-discursivas. A metáfora, enquanto técnica argumentativa na Teoria da Argumentação se constrói com base na retórica grega, como fruto de uma analogia. Em contrapartida, Perelman e Olbrechts-Tyteca (2005) conceituam a metáfora como uma metáfora condensada que resulta da fusão de um elemento do foro com um elemento do tema. Este trabalho, onde as metáforas são chamadas de discursivas por encontrarem no contexto situacional sua ressignificação, tem o objetivo de averiguar qual é o papel dessa metáfora na construção do gênero da petição inicial a partir do entrecruzamento das sequências narrativa e dissertativa. A petição inicial como corpus recebe um recorte de análise: a narrativa dos fatos que é a parte de maior poder de manipulação discursiva do operador do Direito em confronto com as outras partes restritas à normatização legislativa. Sob a hipótese de que a metáfora discursiva resulta da fusão entre foro e tema. Analisam-se estes elementos pelo viés da analogia condensada na interface com a teoria da referenciação à luz da perspectiva sociodiscursivo-interacional. Selecionaram-se para análise sete narrativas dos fatos da petição inicial, cujo foco está no encadeamento narrativo-argumentativo construído pela expressão metafórica destacada, enquanto foro; pela percepção dos elementos discursivos do tema; pela discursivização interpretativa da expressão metafórica com função argumentativa. Para tanto, teve-se como suporte teórico-metodológico estudos desenvolvidos por Perelman e Olbrechts-Tyteca (2005); van Dijk (2012); Mondada e Dubois (2003); Lakoff e Johnson (2002); Koch (2009), Marcuschi (2006), Cavalcante (2003), Leite (2007). Com isso, é possível perceber dentro do contexto que as expressões metafóricas analisadas apresentam por trás delas um teor discursivo que as coloca num estatuto sociodiscursivo e cognitivo.

Orientador: Rosa Attié Figueira / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Estudos da Linguagem / Made available in DSpace on 2018-08-27T17:20:50Z (GMT). No. of bitstreams: 1 Vieira_CamilaRossetti_M.pdf: 1468460 bytes, checksum: 45a22e6cf33a3bf0d419abd061b367a2 (MD5) Previous issue date: 2015 / Resumo: São inúmeros os casos de palavras não dicionarizadas que surgem na fala dos sujeitos, sejam eles adultos ou crianças. A inovação lexical constitui, nesse sentido, um dos fenômenos mais registrados nas línguas, um poderoso fator de mudança linguística e um importante dado de eleição para a discussão da aquisição de linguagem. Dentro das abordagens teóricas da morfologia, a análise desse tipo de dados oferece dois caminhos distintos: (1) a formulação de regras, dentre se destacam as RFPs (Regras de Formação de Palavras), propostas pela Gramática Gerativa no início da década de 1960 (ARONOFF, 1976); e (2) a analogia. Segundo a primeira perspectiva as palavras seriam formadas por uma operação fonológica sobre uma base especificada dando origem a produtos predizíveis em termos sintáticos e semânticos. Já para a segunda, através da qual as palavras são formadas por comparação a um modelo, sobrariam dados mais singulares, em que não houvesse a necessidade de formular regras. O objetivo desta dissertação é o de verificar o potencial explicativo dessas duas visões antagônicas sobre as inovações lexicais na fala da criança. A primeira se baseia em regras e discorre, portanto, sobre questões como os padrões de regularidade e os limites do possível gramatical dentro da formação de novas palavras no português brasileiro. A segunda é a posição teórica interacionista (DE LEMOS, 2003; FIGUEIRA, 2010), que se filia de modo fundamental ao "ideário saussuriano sobre a formação de palavras" o qual, ao ser baseado no mecanismo analógico, é capaz de oferecer múltiplos caminhos para a explicação da fala infantil. Como material empírico, coletamos dados provenientes da observação longitudinal do sujeito RA cujo corpus está disponível no Projeto de Aquisição de Linguagem Oral (CEDAE/IEL/UNICAMP) e, complementarmente, contaremos com um conjunto de dados de autores que já se dedicaram ao tema. Com isso, pudemos averiguar, em um primeiro plano, a impossibilidade de analisar dados da fala da criança de uma perspectiva teórica que só considere formações que estejam de acordo com uma gramática bem comportada, já que as RFPs, que tem por característica principal dizer de um funcionamento formal da língua, nem sempre sustentam o que ocorre na aquisição da morfologia pela criança, uma vez que é claro um movimento do previsível para o imprevisível. Pudemos também ver que a vantagem de assumir a analogia saussuriana para explicar as inovações lexicais não está somente em dar conta de dados que não se deixam explicar por regras muito bem especificadas, mas também está em reconhecer que a criança está submetida ao funcionamento dos mecanismos fundamentais da língua, relações sintagmáticas e associativas / Abstract: There are countless cases of words, which are not in the dictionary that appear in people's speech, whether they are adults or children. The lexical innovation is in this sense one of the most recorded phenomena in the languages, a powerful element for linguistic change and an important point of choice for the language acquisition discussion. Among the morphology theoretical approaches, the analysis of this data leads us to two distinct paths: (1) the formulation of rules, among them stand out the WRFs (Word Formation Rules), which was proposed by the Generative Grammar in the early 1960s (ARONOFF, 1976); and (2) the analogy. According to the first perspective, the words would be formed by a phonological operation on a specific base originating predictable products in syntactic and semantic terms. As for the latter, words would be made by comparison to a model in which more natural data would be left and there would not need to formulate rules. The aim of this dissertation is to verify the potential impact of these two opposing views on the lexical innovations in the child's speech. The first is based on rules and discusses issues such as patterns of regularity and the limits of the grammar constraints within the formation of new words in Brazilian Portuguese. The second is the interactionist theoretical position (DE LEMOS, 2003; FIGUEIRA, 2010), which is affiliated in a fundamental way to "Saussure ideas on the formation of words" which is based on the analogue mechanism that is able to offer multiple pathways to explain the child speech. As empirical source, we collected data from longitudinal observation of the subject RA whose corpus is available in Oral Language Acquisition Project (CEDAE / IEL / UNICAMP) and in addition, we will have a set of authors who have dedicated themselves to the subject. Therewith, we could determine in a foreground the failure to analyze the child's speech data from a theoretical perspective that only considers the formations that are in accordance with formal grammar since the WRFs whose main characteristic is to talk about the formal operation of the language, which does not always maintain what occurs in the child¿s morphology language acquisition, once the movement from predictable to unpredictable is clear. It was also possible to notice the advantage taken by assuming the Saussure analogy to explain that lexical innovation is not only to account data that it is not explained by well-specified rules but also to recognize that the child is subjected to language fundamental mechanisms, syntagmatic and associative relations / Mestrado / Linguistica / Mestra em Linguística

Dans le cadre général d’une sémiotique des cultures, cette recherche a utilisé les propositions épistémologiques et méthodo-logiques de la sémantique interprétative pour renouveler l’analyse de textes irlandais médiévaux. Le but était d’apporter une contribution à une problématique générale intéressant les sciences du langage, mais aussi les sciences historiques : comment fonder la pertinence scientifique d’une interprétation de textes et signes anciens appartenant à une culture différente ? Pour cela il a été choisi de viser les faits sémantiques qui interviennent dans les processus de transfert de sens que la tradition rhétorique nomme comparaison, métaphore ou symbole. L’approche méthodologique a nécessité l’édition d’un corpus interlinéaire offrant un accès direct aux données de l’Electronic Dictionary of the Irish Language. L’étude du lexique a confronté les possibilités définitoires aux afférences contextuelles observées par un relevé systématique des isotopies ciblées.Sur le plan sémantique, l’analyse des processus différentiels qui structurent les molécules sémiques a permis d’observer la circulation des sèmes marquant les analogies intentionnelles. Sur le plan diachronique, la description du système de valeur, pris dans sa globalité, fonde la pertinence de l’interprétation en ce qu’il intègre les normes sociales du contexte historique du signe. Sur le plan des études celtiques, l’analyse des correspondances entre les domaines de l’orientation spatiale, des cycles temporels et des fonctions sociales donne un nouvel accès à la complexité du système de pensée de cette culture. Les formes sémantiques décrites fournissent de nouveaux modèles pour des comparaisons. Sur cette base, les expressions de l’association arbre-savoir ont été décrites pour apporter une solution aux problèmes de l’étymologie de la lexie druid- et proposer le dépassement des approches lexicales monographiques par l’approche intertextuelle. / Within the general framework of a semiotic of cultures, this research has used the epistemological and methodological propositions of the interpretative semantic to renew the analysis of the medieval Irish texts. The aim was to make a contribution to a general question concerning the language sciences but also the historical sciences : How to set up the scientific relevance of a text interpretation and ancient signs that belongs to a different culture ? With this mind, it has been decided to aim at semantic facts which intervene in the transfer process of meaning that the rhetoric tradition name comparison, metaphor or symbol. The methodological approach has required the edition of an interlinear corpus giving a direct access to the data of the Electronic Dictionary of the Irish Language. The study of the lexis has compared the defining possibilities to the contextual afferences has been observed by a systematic survey of targeted isotopies.On the semantic level, the analysis of the differential processes that structures the semic molecules has enabled the possibility to observe the semes circulation that highlight the intentional analogies. On the diachronic approach, the description of the value system taken as a whole, set up the interpretation’s relevance because it’s integrating the social standards of the sign’s historical background. With regard to the Celtic studies, the analysis of correspondence between the fields of spatial orientation, the time cycle and the social functions gives a new access to the complexity of this culture’s system of thought. The described semantic patterns provide new models for comparisons. On this basis, the expressions of association tree-knowledge has been described to find a solution to etymological problems of the lexis druid- and suggest to go beyond the monographic lexical approaches by the intertextual approach.

Carbocyclic nucleoside analogs with norbornane moiety that have been synthesized at IOCB AS CR, represent new potential chemotherapeutic agents with significant activity against Coxsackieviruses. The main objective of this work was to study the metabolism and mechanism of action of the original analog carbocyclic nucleoside MS 254, which is characterized by its antiviral and cytostatic effects. The attention was partially paid also to the two structurally related substances (MS 255, MS 320). In this work, we determined cytotoxicity of these compounds in cell culture and the effect of MS 254 on the amount of total and oxidized glutathione, activity of glutathione-S-transferase (GST), glutathione reductase (GR) and the effect on cellular oxidative stress. The kinetics of the conjugation of MS 254 by human GST was also studied. It was found that of the three substances tested MS 255 was the most cytotoxic and MS 254 was the least cytotoxic compound. It was further found that MS 254 does not cause significant oxidative stress and that it increases the activity of GST and GR in a dose-dependent manner. Michaelis-Menten constant of the conjugation of MS 254 with the glutathione (main metabolic pathway) was determined in the milimolar range, indicating a relatively low affinity of MS 254 for GST.

Structural shape optimisation is a field that has been studied since early on in the development of finite element methods. The sub-fields of shape and topology optimisation are continuously growing in industry and aim to leverage the benefits of technologies such as 3D printing and additive manufacturing. These fields are also being used to optimise designs to improve quality and reduce cost. Gradient-based optimisation is well understood as an efficient method of obtaining solutions. In order to implement gradient-based optimisation methods in the context of structural shape optimisation, sensitivities describing the change of the domain stiffness are required. To obtain the stiffness sensitivities, mesh deformation sensitivities are required. In this study, a mesh generating method is developed that provides mesh deformation sensitivities. For shape optimisation it is advantageous to employ an optimisation algorithm that allows for the manipulation of CAD geometry. This means that the CAD geometry is finalised upon completion of the optimisation process. This, however, necessitates the calculation of accurate sensitivities associated with non-linear geometries, such as NURBS (those present in CAD), by the mesher. The meshing method developed in this study is analogous to a linear truss system. The system is solved for static equilibrium through a geometrically non-linear finite element analysis using Newton’s method. Sensitivities are made available by Newton’s method for use in generating mesh sensitivities for the system. It is important for the mesher to be able to accurately describe the geometrical domain which approximates the geometry being modelled. To do so, nodes on the boundary may not depart from the boundary. Instead of prescribing all boundary nodes, this mesher frees the boundary nodes to move University of Pretoria ii Department of Mechanical and Aeronautical Engineering along, but not away from the boundary. This is achieved using multipoint constraints since they allow for an analytical relationship between boundary node movement and the boundary. Two multipoint constraint (MPC) methods are investigated for boundary discretisation, namely, the Lagrangian and master-slave elimination methods (MSEM). The MSEM presents several difficulties in obtaining convergence on non-linear boundaries in general when compared to the Lagrangian method. The MSEM has reduced computational requirements for a single Newton step, especially when direct solvers are used. However, when indirect solvers are implemented the time difference between the two MPC methods reduces significantly. For a “medium” curvature geometry the Lagrangian implementation has only a 6% time penalty. The Lagrangian method is selected as the preferred MPC method for implementation in the mesher to avoid the convergence problems associated with the MSEM. This is justified on the basis of reliability outweighing the 6% time penalty for what is intended to be a tool in the shape optimisation process. Analytical sensitivities are obtained for the truss system in order to account for the MPC boundaries. The analytical mesh sensitivities are proven to be accurate through comparison with numerical sensitivities. The method is demonstrated to be able to accurately described the mesh deformation throughout the domain for both uniform and non-uniform meshes in the presence of non-linear boundaries. / Dissertation (MEng)--University of Pretoria, 2020. / Mechanical and Aeronautical Engineering / MEng (Mech) / Unrestricted

The thesis specializes in the computational description of pharmaceutically important compounds. A substantial number of pharmaceutical drugs are small molecules that are bound to an active site of an enzyme by the "lock (binding site) and key (drug)" model through non-covalent interactions. The association of enzymes with drugs cause an increase or decrease in the activity of enzymes. The main topic is focused on the computational elucidation of the structural basis for the interactions of the purine-like compounds with the enzyme cyclin- dependent kinase 2 that belongs to the protein-kinase enzyme family. These enzymes play an important role in the cell cycle regulation; their increased activity significantly contributes to the loss of control over cell proliferation, which is one of the primary causes of cancer cell formation. The study describes the binding motifs of roscovitine, which shows an inhibitory effect on the function of cyclin-dependent kinases, and its analogues containing bioisosteric central heterocycles in the complex with cyclin-dependent kinase 2. The binding affinity between the cyclin-dependent kinase 2 enzyme and the inhibitors was quantified as calculated binding scores and evaluated in relation to the conformation of the optimized structures. The hybrid model combining the...

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