The political history of South Africa, especially that of the apartheid years, has affected the structuring and functioning of business in the country profoundly. In general, White business is highly developed and formal, with access to financial and infrastructural support. Black business is often subsistence-based, informal and struggles for access to support mechanisms. These structural inequities have had a depressing impact on the economy that will continue if they are not resolved. Following the 1994 elections, policies and legislation have been introduced aimed at redressing structural imbalances. There is thus both a political and an economic imperative to bridge the gaps that have arisen between Black and White business. The study proposes Black/White joint ventures as a mechanism to this end. The history of Black/White relationships means that these enterprises are likely to face many problems. A model has been developed through the study for the formulation, structuring and operation of Black/White joint ventures that takes into account the factors that are likely to impact on these ventures and affect their success potential. The process of applying the model in practice is directed towards results that are not prejudiced by the background of the parties to the venture. The study expands the concept of joint ventures within the South African context to incorporate initiatives along a continuum ranging from extensions to employment to full joint ventures. Depending on its nature and objectives, a venture may be placed and remain at any stage along the continuum, or may progress along it. Case studies of Black/White joint ventures were investigated in depth and analysed in terms of the application of the model, in order to determine the relevance of the model. In all cases, the success or failure of the venture under scrutiny could be ascribed to the way in which the presence of various elements identified as being components of the model had been accommodated in practice within the venture. The use of the model when applied to formulating, structuring and operating a Black/White joint venture can contribute to its success potential. / Business Management / DBL

Made available in DSpace on 2016-06-02T19:22:49Z (GMT). No. of bitstreams: 1 1958.pdf: 10581288 bytes, checksum: 1dc2b5264737849b6a8842144f1ad052 (MD5) Previous issue date: 2008-05-21 / Financiadora de Estudos e Projetos / The post-traumatic stress disorder (PTSD) affects a portion of subjects exposed to a traumatic event. This disorder leads to long-term alterations in the hypothalamus-pituitaryadrenal (HPA) axis, autonomic and cognitive function. The aim of our study was to evaluate whether the animal model of PTSD proposed for rats could be used in mice and, to evaluate the effect of benzodiazepine, tricycle antidepressant and selective serotonin reuptake inhibitor drugs in the PTSD model. For this we realized the following experiments: Experiment 1- The test consisted of exposure the male mice to inescapable electric footshock (0.3 mA) in the black side (BS) of the black-white box (BW). In the 7th, 14th and 21th day, mice were reexposed to the traumatic reminder on the white side (WS) or BS for 2 min, without footshock. In the 29th day, the animals were submitted to elevated plus-maze (EPM) for record the anxiety indexes [percentage of open arm entries (%OA) and percentage of open arm time (%OT) and as well as general locomotor activity, closed arm entries (CE)]. On day 34 the same animals were submitted to BW test for record the latency to escape (LE) from WS and time spent on WS of the BW box. Experiment 2 the same procedure of experiment 1 was performed, except that the animals were re-exposed at 7th, 14th e 21th days to reminder situation only in WS of BW box for 2 min, without footshock. On day 29th, the animals were exposed to EPM, 30 min after receiving treatment with midazolam. In 34th day the same animals after receiving treatment with midazolam were submitted to BW box test. Experiment 3, 4 and 5 - the same procedure was adopted from experiment 2, except that in 29th day, the animals were not submitted to EPM test and on 34th day 30 minutes after treatment with midazolam, imipramine and sertraline were submitted to BW box. Two-way ANOVA (stimulus x place remainder or treatment) followed by Duncan test showed that PTSD model increased anxiety in mice (P<0.05). The re-exposure in BS promoted anxiogenic-like effect extinction of the model. The midazolam treatment (1.0 and 2.0 mg/kg, i.p.) produced anxiolytic-like effect in maze-mice (P < 0.05) and the 0.5 mg/kg decreased latency to escape of WS (P < 0.05) of BW box and increased the exploratory activity, suggesting involvement of this GABA-benzodiazepine agonist on this PTSD modulation. The EPM test does not interfere in the evaluation of the BW test. It is important to note that no other behaviors were significantly altered by imipramine per se (P < 0.05). The sertraline (5.0 mg/kg), selective serotonin reuptake inhibitor, produced anxiolytic-like effect in the BW test (P < 0.05) and increase exploration activity. These results suggest that the employed PTSD model to study neurobiological disturbances associated with this disorder. / O Transtorno de Estresse Pós-Traumático (TEPT) afeta uma parcela de indivíduos que são expostos a um evento traumático. Este distúrbio induz em longo prazo alterações no eixo HPA, autonômicas e cognitivas. O objetivo deste estudo foi avaliar se o modelo animal de TEPT proposto para ratos poderia ser utilizado em camundongos e investigar o efeito dos fármacos benzodiazepínico, antidepressivo tricíclico e inibidor seletivo da recaptação de serotonina, no modelo de TEPT. Para isso realizamos os seguintes experimentos: Experimento 1- O teste consistiu em submeter camundongos machos, Suíço-albino ao choque inescapável (0,3mA) nas patas no lado escuro (LE) da caixa claro-escuro (CE). No 7º, 14º e 21º dia os camundongos foram reexpostos a situação de lembrança no lado claro (LC) ou LE da caixa por 2 min, sem choque. No 29º dia os animais foram expostos ao labirinto em cruz elevado (LCE), para o registro dos índices de ansiedade [porcentagem de entradas (%EBA) e de tempo gasto nos braços abertos (%TBA) e atividade locomotora, entrada nos braços fechados (EBF)]. No 34º dia os mesmos animais foram submetidos ao teste CE para o registro da latência de fuga (LF) e do tempo gasto no LC da caixa CE. Experimento 2 o mesmo procedimento do experimento 1 foi adotado, exceto que os animais foram reexpostos no 7º, 14º e 21º dia a situação de lembrança apenas no LC da caixa por 2 min, sem choque. No 29º dia os animais, 30 min após receberem tratamento com midazolam, foram expostos ao labirinto em cruz elevado (LCE). No 34º dia os mesmos animais após receberem o mesmo tratamento farmacológico, foram submetidos ao teste CE. Experimento 3, 4 e 5 o mesmo procedimento do experimento 2 foi adotado, exceto que no 29º dia os animais não foram submetidos ao LCE e no 34º dia, 30 min após receberem tratamento com midazolam, imipramina e sertralina foram submetidos ao teste CE. A ANOVA de duas vias (estímulo x local da SL ou tratamento) seguido do teste de Duncan mostrou que o modelo de TEPT produziu aumento da ansiedade nos camundongos (P < 0,05). As reexposições no LE promoveram extinção do efeito ansiogênico do modelo. O tratamento com midazolam (1,0 e 2,0 mg/kg) produziu efeito ansiolítico no LCE (P < 0,05), e a dose de 0,5 mg/kg reduziu a latência de fuga do ambiente claro (P < 0,05) no teste CE e aumentou a atividade exploratória, sugerindo o envolvimento deste agonista GABA-benzodiazepínico na modulação do TEPT. O LCE não interferiu na avaliação do teste CE. A imipramina não apresentou efeito sobre os camundongos (P > 0,05), ou seja, ausência de efeito deste antidepressivo tricíclico nos sintomas do TEPT. A sertralina (5,0 mg/kg) produziu efeito ansiolítico no teste CE (P < 0,05) e aumento na atividade exploratória, mostrando o envolvimento deste inibidor seletivo da recaptação de serotonina na modulação do modelo. Estes resultados sugerem que o modelo de TEPT utilizado poderá ser empregado para o estudo das alterações neurobiológicas envolvidas neste distúrbio.

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Examensarbetet har utförts i samarbete med företaget LVI (Low Vision International) som tillverkar elektroniska hjälpmedel för synskadade. LVI utvärderar vid jämna mellanrum nya LCD-bildskärmar för deras produkter. LVI behöver metoder samt utrustning för att mäta bildskärmars responstid och latens. Både responstiden och latensen ger fördröjningar vilket t.ex. leder till att bilden blir oskarp, rörliga föremål får en svans efter sig eller att lju- det kommer före bilden. I detta arbete utförs en grundlig förstudie som behandlar bild- skärmars responstid och latens samt ger ett underlag för att konstruera eller köpa mätut- rustning för responstidsmätningar. I förstudien framkommer den standardiserade mätmeto- den ”grey-to-grey” som LVI kan använda för att mäta responstiden. En mätkrets konstrue- ras för att mäta responstiden samt beställs en dedikerad enhet för latensmätning. För att ut- värdera mätmetoderna utförs ett antal tester med mätkretsen för responstid och den dedike- rade enheten för mätning av latens. Mätningarna visar senare att mätmetoden ”grey-to- grey” är den som LVI ska använda men metoden behöver vidareutvecklas. Den dedikerade enheten för latensmätningar visar sig mäta en del av responstiden och bör därför endast an- vändas som komplement till responstidsmätningen vid jämförelser mellan olika bildskär- mar. Arbetet levererar en förstudie i LCD-bildskärmars responstid och latens, en vidareut- vecklad version av ”grey-to-grey”-metoden, mätutrustning för responstidsmätning samt den dedikerade mätenheten för latens till företaget LVI. / The thesis was performed in collaboration with the company LVI (Low Vision Interna- tional) that manufactures electronic devices for the visually impaired. LVI evaluates new LCD displays for their products at regular intervals. LVI need methods and equipment for measuring response time and input lag. Both response time and input lag cause delays, which results in such things as image blur, ghosting after moving objects or a delay between sound and image. The preliminary study reveals the standardized method “grey- to-grey” that LVI can use to measure response time. A measurement circuit was constructed to measure response time and a dedicated unit for input lag measurement was ordered. To evaluate the measurement methods a number of tests were conducted with the response time circuit and the dedicated input lag unit. The measurements showed that the method LVI shall use is the "grey-to-grey” method but it needs further development. It turned out that the dedicated unit for input lag measured a portion of the response time and should therefore only be used as a complement to the response time measurement when comparing displays. The thesis delivers a preliminary study in LCD displays response times and input lag, a further developed version of the “grey-to-grey” method, measurement equipment for response time and a dedicated unit for input lag measurements to the company LVI.

Indiana University-Purdue University Indianapolis (IUPUI)