Šiame baigiamajame magistro darbe analizuojamos kriterijaus suderinamumo hipotezėms tikrinti savybės. Siekiama jį patikslinti, įvedant kriterijaus statistikos korekciją . Atlikus klasikinio ir modifikuoto kriterijų tikslumo palyginamąją analizę, naudojant modeliuotas reikšmes, padaryta keletas išvadų. Kriterijus, kuris remiasi statistika , šiek tiek patikslina hipotezių tikrinimo rezultatus, tačiau, kai imtis yra pakankamai didelė, kriterijų tikslumas beveik nesiskiria. Be to, kriterijus, kuris remiasi modeliuotomis reikšmėmis taip pat yra pakankamai tikslus. Taigi, naudojantis šiuolaikinėmis pažangiomis technologijomis, ir, modeliuojant pakankamai didelę a.d. imtį, šio kriterijaus galėtų pakakti, kad patikrinti suderinamumo hipotezę. Skaičiavimų palengvinimui sukurtos makroprogramos a.d. momentams skaičiuoti ir a.d. realizacijoms modeliuoti. / The main purpose of this master thesis is to improve the clasical chi square goodness of fit test so that it would depend less on the rule, according to which the data is divided into intervals, and on the hypothetical probabilities. The tasks of the paper are the following: • To examine (according to the literature ([1], [2], [3])) theoretical and applied aspects of constructing chi square test; • To analyse the methods of graphic representation of the empirical characteristics of the data and graphic comparison with their theoretical equivalents. Altogether to look through the ways of dividing the data into intervals (determining their number and length); • To calculate the mean, variance and third central moment of chi square test statistics and to analyse their properties; • To create a macro for counting the previously mentioned three moments using SAS software; • To create a macro for modeling statistics and to construct goodness of fit test according to the modeled values using SAS software; • To construct an aproximate modified chi square goodness of fit test based on a new statistics; • To perform comparison of the clasical and modified goodness of fit tests, having the modeled values; Analysis of graphing the empirical data and comparison with the theoretical equivalents has showed that the distribution (density) is recognised easier when the probabilities of values to be prescribed to certain intervals are equal. This way the execution of computations is easier as... [to full text]

Malgré les vastes études démontrant le rôle de la conformation génomique dans le contrôle transcriptionnel, de nombreuses questions restent en suspens, et en particulier, comment ces structures chromatiniennes sont formées et maintenues. Pour mieux comprendre les liens entre l’état de la chromatine au niveau des éléments régulateurs, la topologie de la chromatine et la régulation de la transcription, nous utilisons la technique CHi-C basée sur la technologie de capture de la conformation chromosomique (3C). En utilisant deux stratégies de capture ciblant deux différentes structure chromatiniennes (les boucles chromatiniennes et les domaines topologiques), nous avons pu décrypter la structure chromatinienne associée à la différenciation des thymocytes et mettre en évidence des mécanismes de contrôle transcriptionnel de certains gènes. Les expériences futures de l’équipe vont consister à examiner les facteurs (hors transcription) qui peuvent influencer l'architecture de la chromatine, comme la liaison différentielle des CTCF, et comment ces facteurs peuvent être coordonnés par le contrôle de transcription. / Chromosome folding takes place at different hierarchical levels, with various topologies correlated with control of gene expression. Despite the large number of recent studies describing chromatin topologies and their correlations with gene activity, many questions remain, in particular how these topologies are formed and maintained. To understand better the link between epigenetic marks, chromatin topology and transcriptional control, we use CHi-C technique based on the chromosome conformation capture (3C) method. By using two capture strategies targeting two different chromatin structures (chromatin loops and topological domains), we have been able to decipher the chromatin structure associated with thymocyte differentiation and to highlight mechanisms for the transcriptional control of certain genes. Future experiments of the lab will examine mechanisms other than transcription which may influence chromatin architecture, such as differential binding of CTCF, and how these may interplay with transcriptional control and chromatin architecture.

Cette thèse propose une analyse économique de la gestion des déchets ménagers au Vietnam.Après avoir étudié les différents acteurs et leurs domaines de compétence à l’échellenationale, elle cible plus particulièrement les zones urbaines du pays afin d’identifier la naturedes déchets produits, les modalités de régulation et de financement de leur gestion. Parailleurs, une évaluation des comportements des ménages en faveur de l'amélioration de lagestion des déchets ménagers est proposée à partir d’une évaluation contingente. A partird’une enquête réalisée auprès de 416 ménages dans la ville de Hanoï et de 444 ménages dansla ville d’Ho Chi Minh, l’estimation du consentement à payer (via la méthode d’Heckman)révèle que les ménages sont disposés à payer respectivement environ 0.51 euros et 0.56 eurospar mois par ménage pour une amélioration de la qualité du service d’élimination des déchetsménagers. Les résultats de cette étude empirique sont également mobilisés pour proposer desrecommandations concrètes visant à assurer une plus grande efficacité dans la gestion desdéchets au Vietnam. / This thesis provides an economic analysis of household waste management in Vietnam. Afterstudying the various stakeholders and their fields of competence at the national level, ittargets the urban areas of the country in particular in order to identify the nature of the wasteproduced and the regulation and financing conditions for its management. Furthermore, anassessment of household behavior vis-à-vis the improvement of household waste managementis proposed using a contingent evaluation. Starting from a survey carried out on 416households in the city of Hanoi and 444 households in Ho Chi Minh City, an estimation of thewillingness to pay (using the Heckman method) reveals that households are prepared to payabout 0.51 euros and 0.56 euros per month per household respectively to improve the qualityof service of household waste disposal. The results of this empirical study are also used topropose concrete recommendations aiming to ensure greater efficiency in household wastemanagement in Vietnam.

The increasing usage of algorithms and extensive collections of data have changed the discipline of finance and created new possibilities for analyzing the financial markets. To further explore the potential of developing new methods for understanding financial market behaviour, this thesis examines the first digit probability distribution of Benford's Law and its applicability within the financial markets. The research investigates various indices', equities', and technical analysis tools' conformity to Benford's Law by using relative price changes and volume traded. It was found that both indices and equities exhibit resemblance with Benford's Law, whereas technical analysis tools did not. In addition, the relevance of data frequency was explored, but it was deemed not to have any effect on conformity found. In an attempt to apply the findings, a regression analysis was conducted to forecast volatility. However, even though correlation was found, the regression model failed to predict future volatility accurately. / Den ökade användningen av algoritmer och omfattande datainsamling har förändrat det finansiella spelrummet och skapat nya möjligheter för analys av finansmarknaden. För att ytterligare undersöka potentialen i att utveckla nya metoder för att förstå finansmarknadens beteende utforskar denna avhandling Benfords lag och dess tillämpbarhet på den finansiella marknaden. Studien testar olika index, aktiers och tekniska analysverktygs överensstämmelse med Benfords lag genom att använda relativa prisförändringar och handlad volym. Det visade sig att både index och aktier följer Benfords lag medan tekniska analysverktyg inte gjorde det. Dessutom undersöktes datafrekvensens relevans, men detta ansågs inte ha någon effekt på överensstämmelsen med fördelningen. I ett försök att tillämpa resultaten genomfördes en regressionsanalys för att prognosticera volatilitet. Korrelation hittades men regressionsmodellen gav inte ett tillförlitligt resultat.

Studien syftar till att undersöka vilken förvaltningsstrategi som är bäst, fonders prestation genom olika ekonomiska förhållanden samt persistens på den svenska fondmarknaden. Huvudsyftet är att undersöka om fonders föregående prestation kan användas för att förutsäga framtida avkastning. Genom att använda etablerade mått på förvaltningsprestation som Jensens Alfa, Sharpekvoten och Modiglianis riskjusterad prestation (𝑀2) jämförs fonders prestation. För att identifiera persistens jämförs fondernas avkastning med medianavkastning under en specifik period. Genom statistiska tester i form av Oddskvot, Chi-två-test och regressionsanalys fördjupas studien ytterligare. Resultaten från studien visar enskilda fall av persistens, men inga konsekventa mönster kan utläsas för alla fonder. Slutsatsen från studien är att det inte går att slå fast en överlägsen förvaltningsstrategi. Slutsatsen indikerar även att det inte finns några signifikanta indikationer på att det går att förutspå framtida avkastning utifrån föregående tidsperiods avkastning. / The study investigates which management strategy is superior, funds’ performance across different economic conditions and persistence in the Swedish fund market. The main objective is to examine whether past fund performance can be utilized to predict future returns. Through using established performance measures such as Jensen’s Alpha, The Sharpe Ratio and Modigliani’s risk- adjusted performance (𝑀2), we compare fund performance. To identify persistence, funds’ returns are compared with median returns over a specific period. Through statistical tests such as Odds Ratio, Chi-square test and regression analysis, the study is further elaborated. The results of the study reveal isolated instances of persistence, but no consistent patterns can be discerned across all funds. The conclusion drawn from the study is that no superior management strategy can be definitively established. Additionally, the findings suggest no significant indications that past period returns can predict future returns.

published_or_final_version / Sports Science / Master / Master of Science in Sports Science

One in seven women will develop breast cancer. Most will suffer medically and psychologically from the disease. Complementary and alternative medicine (CAM) interventions such as tai chi and spiritual growth groups have proven to be beneficial for this population, however, many questions remain regarding the mechanisms of action in these techniques. The purpose of this study was to evaluate the psychosocial effects and mechanisms of two 10-week interventions (tai chi and spiritual growth groups) within the context of a larger randomized, controlled NCI-funded study (R01 CA114718, Nancy McCain, PI) in women recently diagnosed with breast cancer. The present study evaluated dispositional predictors (optimism, attentional style, emotional intelligence) as well as the effects of these interventions on measures of mood, coping, and quality of life (QOL) in a subsample of 40 women enrolled in the larger study. Participants were primarily Caucasian (73%) with a mean age of 49 years. Data were collected just prior to beginning chemotherapy when the interventions began, and again 10 weeks later. Twenty-nine participants completed the interventions and had both time 1 and time 2 data. There were 15 women in the tai chi group, 6 in the spiritual growth group, and 8 in the control group. Results from this subsample revealed differential effects of the interventions on total mood disturbance, depressive symptoms and QOL. Optimism was a significant predictor of TNF-α levels, monitoring was a significant predictor of changes in anxiety and QOL, and emotional intelligence was a significant predictor of changes in QOL. These findings give promise to future studies aimed at cross-validating with a larger sample. This research could potentially guide the treatment of women with breast cancer by providing enhanced understanding of how tai chi and spiritual growth groups affect this population psychologically, behaviorally, and biologically.

Title: The effect of selected exercise trends activating core stability system in dialysed patients - overview of the literature. Objective: Objective of this diploma thesis was to obtain and compare available studies dealing with exercise trends such as yoga, pilates, tai chi and balance training devices and to evaluate their effect on core stability system of dialysed patients. Methods: This diploma thesis has descriptively-analytical character and is structured in a form of literary review. Results: Issue of dialysis in connection with core stability system has not been sufficiently explored yet in literary sources. In conclusion, there were no studies found dealing with effects of particular exercise trends on core stability system of dialysed patients. In order to comprehend this issue an overview was written to define the effect of such trends on dialysed patients. Also, complications arising from renal failure and dialysis were mentioned such as hypertension, diabetes melitus and obesity. The effect of these trends on core stability system of healthy population as well as patients suffering from chronic back pain was described too. Conclusion: Some extent of coherence was found between strengthening core stability system and its effect on dialysed patients however further in- depth research...

University of Macau / Faculty of Social Sciences. / Department of Government and Public Administration

University of Macau / Faculty of Arts and Humanities. / Department of Portuguese