Background and objective: Approximately 6000 cardiac surgeries were performed in Sweden 2013 and a known complication after such procedure is chronic pain. One surgical technique in open cardiac surgery includes a sternal retraction and this creates sensitive areas of pain which could lead to nerve damage. Few studies have been looking at this in a qualitative way. The aim of this study was to illuminate the  experiences of chronic pain in former patients, two years after cardiac surgery. Methods: This study is of qualitative design. Four women and six men (age 43 to 87 years), assessed as having chronic pain after surgery, were interviewed two years after cardiac surgery. The data was analyzed using qualitative content analysis with an inductive approach. Findings: Three categories and nine sub-categories were formulated. The first category was ‘feeling limitation in daily life’, with the subcategories; ‘everyday activities become painful’, ‘losing control of the body’, ‘pain is unpredictable’and‘insecurity’. The second category was;‘being reminded of illness’, with the subcategories; ‘the scar is a visually memory’and ‘being grateful’.The last category was; ‘coping with pain’, with the subcategories; ‘adaption for handling pain’, ‘different shades of pain’ and ‘pain is transient’. Conclusion: Chronic pain is a personal experience and can be described in a both physical and emotional way. Findings showed that participants, in some way, almost daily were reminded about their experiences of cardiac surgery either by looking at their scar or that they were restricted in daily activities. Despite the limitation in life; could participants describe their experience of chronic pain as manageable.  Pain was described in several ways, and the participants had different coping strategies. Most of the participants also were assured that pain eventually would pass or get better. / Bakgrund och syfte: Cirka 6000 öppna hjärtoperationer genomfördes i Sverige 2013 och en känd komplikation är kronisk smärta. En av de kirurgiska teknikerna är öppen hjärtkirurgi vilken inkluderar delning av sternum, vilket kan åstadkomma ett flertal smärtkänsliga områden, som i sin tur kan leda till nervskador. Få studier har belyst detta kvalitativt. Syftet med denna studie var att belysa patienters upplevelse av kronisk smärta, två år efter öppen hjärtkirurgi. Metod: Föreliggande studie har en kvalitativ design. Fyra kvinnor och sex män (43-87 år), intervjuades två år efter öppen hjärtkirurgi. Dataanalysen var kvalitativ innehållsanalys med en induktiv ansats. Resultat: Tre kategorier och nio underkategorier konstruerades. Den första kategorin var “att känna begränsningar i vardagligt liv”, med underkategorierna; ‘vardagsaktiviteter blir smärtsamma’, ‘förlora kontrollen över kroppen’, ‘smärtan är oförutsägbar’ och ‘osäkerhet’. Den andra kategorin var; ‘en påminnelse om sjukdom’, med underkategorierna; ‘ärret är en visuell påminnelse’ och ‘tacksamhet’. Den sista kategorin var: ‘hantera smärta’, med underkategorierna; ‘anpassning för att hantera smärtan’, ‘olika nyanser av smärta’ och ‘smärtan är övergående’. Slutsats: Smärta är en personlig upplevelse och kan beskrivas både fysiskt och känslomässigt. Resultatet visade att deltagarna, på något sätt, nästan dagligen påmindes om deras erfarenhet efter hjärtkirurgi, antingen genom att titta på ärret eller genom att de blev begränsad i sina vardagliga aktiviteter. Trots begränsning i livet, kunde deltagarna beskriva upplevelsen av smärta som hanterbar. Deltagarna beskrev smärtan på olika sätt och de hade olika copingstrategier, de flesta av deltagarna var övertygade om att smärtan skulle gå över eller bli bättre.

Background: Chronic pain is a major public health problem. The impact of stages of chronic pain adjusted for disease load on societal burden has not been assessed in population surveys. Methods: A cross-sectional survey with 4360 people aged ≥ 14 years representative of the German population was conducted. Measures obtained included demographic variables, presence of chronic pain (based on the definition of the International Association for the Study of Pain), chronic pain stages (by chronic pain grade questionnaire), disease load (by self-reported comorbidity questionnaire) and societal burden (by self-reported number of doctor visits, nights spent in hospital and days of sick leave/disability in the previous 12 months, and by current unemployment). Associations between chronic pain stages with societal burden, adjusted for demographic variables and disease load, were tested by Poisson and logistic regression analyses. Results: 2508 responses were received. 19.4% (95% CI 16.8% to 22.0%) of participants met the criteria of chronic non-disabling non-malignant pain. 7.4% (95% CI 5.0% to 9.9%) met criteria for chronic disabling non-malignant pain. Compared with no chronic pain, the rate ratio (RR) of days with sick leave/disability was 1.6 for non-disabling pain and 6.4 for disabling pain. After adjusting for age and disease load, the RRs increased to 1.8 and 6.8. The RR of doctor visits was 2.5 for non-disabling pain and 4.5 for disabling pain if compared with no chronic pain. After adjusting for age and disease load, the RR fell to 1.7 and 2.6. The RR of days in hospital was 2.7 for non-disabling pain and 11.7 for disabling pain if compared with no chronic pain. After adjusting for age and disease load, the RR fell to 1.5 and 4.0. Unemployment was predicted by lower educational level (Odds Ratio OR 3.27 [95% CI 1.70-6.29]), disabling pain (OR 3.30 [95% CI 1.76-6.21]) and disease load (OR 1.70 [95% CI 1.41-2.05]). Conclusion: Chronic pain stages, but also disease load and societal inequalities contributed to societal burden. Pain measurements in epidemiology research of chronic pain should include chronic pain grades and disease load.

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 4 uppsatser.

Thesis (M.S.W.) - Carleton University, 2007. / Includes bibliographical references (p. 133-146). Also available in electronic format on the Internet.

Bakgrund: Kronisk smärta är ett globalt fenomen där var femte människa regelbundet upplever måttlig till svår smärta. Otillräcklig förståelse och kunskap om egenvård av kronisk smärta kan vara ett hinder för många äldre personer. Otillräcklig smärtlindring kan medföra onödigt lidande för patienten. Kronisk smärta kan också påverka den äldre personens vardag så väl som deras livskvalité. Syfte: Syftet med studien var att belysa hälso- och sjukvårdspersonalens erfarenhet av omvårdnad hos äldre personer med kronisk smärta. Metod: Denna studie var en litteraturöversikt med induktiv design med 11 kvalitativa artiklar som urval. Resultat: Hälso- och sjukvårdspersonalen uttryckte att det fanns ett ökat behov av kunskap om smärta, eftersom de stundtals tvivlade på sin egen förmåga att bedöma och lindra smärtan hos äldre personer, vilket gav en känsla av maktlöshet. Erfarenheten var att samarbete, tillit och en fungerande kommunikation inom det multi-professionella teamet var viktigt för att patientens smärtlindring skulle bli optimal. Slutsats: För att den äldre patienten med kronisk smärta ska få en god smärtlindring krävs att hälso- och sjukvårdspersonalen har kunskap, samarbetsförmåga och självinsikt. / Background: Chronic pain is a global phenomenon, where every fifth person experiences moderate to severe pain regularly. Insufficient understanding and knowledge of chronic pain can be an obstacle for elderly patients. Pain relief that is insufficient contributes to unnecessary suffering for the individual. Chronic pain can also influence elderly patients' everyday life, as well as their quality of life. Aim: The aim of this study was to describe the health care staffs’ experience of nursing in elderly patients with chronic pain. Method: This study was a literature review with an inductive design in addition to a selection of qualitative articles. Result: The health care staff expressed a need for increasing the knowledge about pain, as they sometimes doubted their ability to assess and alleviate the pain in the elderly, which gave a sense of the staff being powerless. The experience was that collaboration, trust, and a functioning communication within the multi-professional team had an important role for optimal pain relief. Conclusion: In order for the elderly patient with chronic pain to receive sufficient pain relief, the healthcare professionals need abilities such as knowledge, cooperation and self-awareness.

Etude longitudinale comparative de l’efficacité d’un programme cognitivo-comportemental de groupe pour l’autogestion de la fibromyalgie : 112 patients suivis en ambulatoire à l’hôpital, âgés entre 18 et 66 ans, répartis au hasard dans un bras traitement GTCC (8 séances, 2 heures par semaine) ou dans un bras témoin GTEM (1 séance, 2 heures d’information d’éducation thérapeutique) organisés en groupes de 5 à 9 patients. Tous ont répondu à des questionnaires avant l’intervention et ont été réévalués avec des tests cliniques 3, 6 et 12 mois après le traitement. Les résultats montrent : il n’y pas de différences significatives entre GTCC et GTEM. Pour GTCC nous constatons des changements significatifs : amélioration de la motivation au maintien des acquis, de la qualité de vie spécifique à la fibromyalgie, de l’état de santé général ; et diminution du coping dramatisation, de l’intensité de la douleur, de l’anxiété et de la dépressivité. La sévérité de la douleur, reste inchangée. La dépressivité et la douleur peuvent jouer un rôle prédictif du développement de facteurs cliniques. Un programme TCC pour l’autogestion de la fibromyalgie est efficace à court et long terme / A longitudinally comparative study assessed a group self-management CBT program efficacy for 112 fibromyalgia hospital outpatients, aged 18 to 66. They were andomized in treatment group GTCC (8 weekly 2 hours sessions) and reference group GTEM (one 2 hours therapeutic patient education session), both organized with 5 to 9 patients. All patients were submitted a socio-demographic data and clinical questionnaire before intervention and a clinical re-evaluation at 3, 6 and 12 months after treatment. No significant differences between GTCC and GTEM groups were found. GTCC results shows significant short and long-term improvement in motivation to maintain the new strategies, quality of life and health status; and in decreased catastrophizing coping strategies, pain intensity, anxiety and depression propensity. No change in pain severity was found. Depression and pain can predict the development of psychological and clinical factors. A fibromyalgia self-management CBT program is efficient at short and long term.

Les recherches actuelles ne permettent pas de connaître le rôle de certaines manifestations de la gestion émotionnelle (stratégies cognitives de régulation émotionnelle ou la suppression expressive), chez les personnes atteintes de fibromyalgie. Objectif : l’objectif principal de cette recherche est de déterminer les relations existantes entre gestion émotionnelle (alexithymie, stratégies cognitives, suppression émotionnelle), détresse émotionnelle provoquée par la douleur (irritabilité, anxiété, dépression) et handicap. Méthodologies : cette étude fait appel à deux démarches méthodologiques différentes et complémentaires : (1) une démarche quantitative, qui s'appuie sur un échantillon total de 417 participants ayant complété des questionnaires (TAS-20, CERQ, ERQ, PCS-CF, HADS, CHIP, MPI, FIQ) ; (2) une démarche qualitative, qui repose sur un échantillon de 10 participants ayant participé à un entretien semi-directif. Résultats : les résultats quantitatifs de cette étude montrent qu'il existe un effet de la détresse émotionnelle provoquée par la douleur sur le handicap, médiatisé par la gestion émotionnelle. L'approche qualitative montre que le recours à des stratégies de gestion émotionnelle habituellement associées au mal-être (anxiété/dépression) varie, en fonction du contexte personnel des participants Elle permet également d'apprendre que certains participants ignorent comment ils gèrent leurs émotions et que la détresse émotionnelle provoquée par la douleur ne leur permet pas d'être disponibles (que ce soit sur le plan attentionnel ou émotionnel) pour gérer d'autres évènements émotionnels. Conclusion : les résultats de cette étude peuvent avoir des implications sur le plan psychothérapeutique. Notamment, il serait souhaitable de mettre l'accent sur la gestion de la douleur dans un premier temps, puis de proposer aux patients, dans un second temps, une approche psycho-éducative et psychothérapeutique de la gestion émotionnelle. / Research does not provide information about the role of some manifestations of emotional management such as cognitive strategies of emotional regulation and emotional suppression, in fibromyalgia. Objective: the main objective of this study is to determine the links between emotional management, emotional distress (irritability, anxiety and depression) caused by pain and disability. Methods: this study is based on two different and complementary methodological approaches: (1) a quantitative approach, with a total sample of 417 participants who replied to questionnaires (TAS-20, CERQ, ERQ, PCS-CF, HADS, CHIP, MPI, FIQ) ; (2) a qualitative approach, with a sample of 10 participants who was subject to a semi-directive interview. Results: Quantitative results of this study show that there is an effect of pain emotional distress caused by pain on disability, mediated by emotional management. Qualitative approach enhances a better understanding of processes involved, through the recounting of participants. Indeed, some of them not know how they manage their emotions. Moreover, emotional distress caused by pain does not allow them to be able to manage other emotional event. Conclusion: Results of this study can have psychotherapeutic implications. Notably, it would be beneficial to work on pain management, in the first time, and subsequently to provide patients a psycho-educational and psychotherapeutic approach of emotional management (explain that we can manage emotions, how and what are the consequences).

La douleur chronique (DC) est un trouble sensoriel complexe caractérisé par des changements structurels, c'est-à-dire par des réarrangements anatomiques sévères du cortex somatosensoriel et des changements fonctionnels, à savoir des anomalies dans la connectivité fonctionnelle du réseau et la transmission de l'information au niveau du circuit thalamo-cortical. Structurellement, dans chaque module cortical, une unité morpho-fonctionnelle peut être reconnue, appelée unité neuro-gliale-vasculaire, où les cellules gliales représentent les structures de pontage permettant le transfert de métabolites et d'oxygène aux neurones. La dépendance fonctionnelle entre les éléments neuronaux et vasculaires, explorée en grande partie par microscopies confocale 3D et biphotonique a élargi le concept de l'espace synaptique en une forme plus complexe, appelé «synapse tripartite», où malgré la présence de neurones pré et post-synaptiques, un composant glial est ajouté face au contexte microvasculaire. Il semble donc correct d'analyser les effets microscopiques corticaux de l'image macroscopique. Des études récentes de notre groupe ont traité de l'origine et l'évolution de la DC dans des modèles expérimentaux de rat DC (Seltzer) grâce à des analyses microstructurales et fonctionnelles axées sur le substrat neuronal corticale et les propriétés micromorphologiques et vasculodynamiques du sang. La microarchitecture du réseau vasculaire cortical a été révélée via la microtomographie par rayonnement X synchrotron aux lignes ID17 et ID16A (ESRF, Grenoble) ainsi qu’à la ligne TOMCAT (SLS, Villigen). S’en est suivi une analyse morphométrique du réseau vasculaire 3D par squelettisation et transformation du graphe spatial. Ensuite, une étude comparative "Neuropathique vs Contrôle", basée sur les propriétés du réseau vasculaire (nombre de vaisseaux, points de branche, segments de squelette et diamètre du vaisseau) a montré des changements évidents dans les compartiments microvasculaires corticaux: une augmentation généralisée des micro-vaisseaux et des capillaires sanguins dans les régions étudiées (cortex somatosensoriel SS1) caractérisent tous les rats DC. Parallèlement, une réduction du diamètre moyen des vaisseaux des rats DC prouve que les capillaires et les microvaisseaux ont une affinité prédominante pour ces événements angiogénétiques. L'évolution de la néogénèse est très présente dès la première étape de la neuropathie (2 semaines), puis diminue mais persiste durant la dernière étape considérée (6 mois). En outre, un flux sanguin maximal accru a été trouvé dans l'état de DC, indiquant que les réseaux vasculaires DC sont compatibles avec un flux enrichi soutenu par l'angiogenèse. Ces résultats provenant de la micro et nanotomographie ont été confirmés via microscopie en immunofluorescence: les échantillons DC ont montré la positivité à trois marqueurs de néogénèse vasculaire (VEGFR1, VEGFR2 et VWF). En parallèle, pour analyser fonctionnellement la genèse et l'évolution des circuits thalamo-corticaux dans les conditions de DC, l'activité neurale a été enregistrée par une matrice de 32 microélectrodes implantée dans le cerveau, recevant simultanément des signaux du noyau thalamique VPL et du cortex SS1. Tous les rats DC montrent des troubles de connectivité révélés aussi par l'évolution de la topologie du réseau de «Modules et Hubs» à une organisation «aléatoire» où les connexions fonctionnelles intra et intercommunautaires diminuent. Ces résultats confirment comment la dynamique neuronale est liée à l'activité vasculaire: les événements néo-génétiques des microvaisseaux corticaux dans la DC sont fortement corrélés aux anomalies fonctionnelles de la dynamique des réseaux neuronaux. L'implication microvasculaire dans la DC ouvre une nouvelle façon de l’interpréter, non seulement reconnue comme pathologie sensorielle, mais aussi comme une maladie neurologique où les réseaux de connectivité neuronale et vasculaire sont largement impliqués dans le système. / Chronic pain (CP) is a complex sensory disorder characterized by structural changes, i.e. severe anatomical rearrangements of somatosensory cortex, and functional changes, i.e. anomalies in network functional connectivity and in information transmission at the level of thalamo-cortical circuit. From the structural point of view, within each cortical module, a morpho-functional unit can be recognized, also called neuro-glial-vascular unit, where the glial cells represent the bridging structures allowing for the transfer of metabolites and oxygen to neurons. Namely, the functional dependency between neuronal and vascular elements, largely explored by 3D confocal microscopy and two photon microscopy, has expanded the concept of synaptic space to a more complex form, indicated as “tripartite synapse”, where besides the presence of the pre- and post- synaptic neurons, a glial component is added facing on the microvascular context. Due to this dependency it appears, thus, correct to analyse the cortical microscopical effects of the macroscopical picture. Novel studies by our group have recently investigated CP origin and evolution in experimental CP rat models (Seltzer) through microstructural and functional analyses focused both on the cortical neuronal substrate and the blood micromorphological and vasculodynamic properties. The 3D microarchitecture of cortical vascular network has been revealed by means of synchrotron X-ray micro Computed Tomography (CT) at the ID17 and ID16A beamlines (ESRF, Grenoble) and the TOMCAT beamline (SLS, Villigen). A subsequent morphometric analysis of the 3D vascular network has been implemented by means of skeletonization and spatial graph transformation. Then, a comparative study “Neuropathic vs Control”, based on the estimated vascular network properties (number of vessels, branch points, skeleton segments and vessel diameter), showed evident changes in cortical microvascular compartments: a widespread increase of blood microvessels and capillaries in the investigated regions (the somatosensory [SSI] cortical area) has been found in all CP rats. In parallel, a reduced mean value of vessel diameter in all CP rats prove that capillaries and small microvessels are predominantly interested by these angiogenetic events. By investigating the time evolution of the neogenesis, it appears strongly present since the first stage of the neuropathy (2 weeks), fading away, but still present, during the last time stage considered (6 months). In addition, an increased maximum blood flow, sustained by the vascular network, has been found in CP condition, indicating that CP vascular networks are compatible with an enriched blood flow sustained by the promoted novel angiogenesis. These results from micro- and nano-tomography have been further confirmed also by immunofluorescence microscopy analysis: CP samples have shown the positivity to three markers of vascular neo-genesis (VEGFR1, VEGFR2 and VWF). In parallel, to functionally analyse the genesis and the evolution of the thalamo-cortical circuits in CP conditions, the neural activity has been recorded by means of 32-microelectrode matrices implanted in the brain, simultaneously receiving signals from the VPL thalamic nucleus and the SS1 cortex. All the CP groups show connectivity disorders exhibited also by the evolution of the network topology from “Modules and Hubs” to a “random” network organisation where the intra-community and inter-community functional connections decrease. These results clearly confirm how the neuronal dynamics is strictly linked to the vascular activity: the cortical microvessel neo-genetic events in CP are strongly correlated to the functional anomalies in neuronal network dynamic. The microvascular involvement in CP opens a new way of interpretation of CP disease, not only recognized as sensory pathology, but also as a neurological disease where neuronal and vascular connectivity networks are extensively involved in the whole system.

abstract: "Too often, people in pain are stuck in limbo. With no diagnosis there is no prognosis. They feel that without knowing what is wrong, there is no way to make it right" (Lewandowski, 2006, p. ix). Research has shown that environmental factors, such as views of nature, positive distractions and natural light can reduce anxiety and pain (Ulrich, 1984). Patients with chronic, painful diseases are often worried, anxious and tired. Doctor's appointments for those with a chronic pain diagnosis can be devastating (Gilron, Peter, Watson, Cahill, & Moulin, 2006). The research question explored in this study is: Does the layout, seating and elements of positive distraction in the pain center waiting room relate to the patients experience of pain and distress? This study utilized a mixed-method approach. A purposive sample of 39 individuals participated in the study. The study employed the Positive and Negative Affect Schedule (PANAS), the Lewandowski Pain Scale (LPS) and a researcher developed Spatial Perception Instrument (SPI) rating the appearance and comfort of a pain center waiting room in a large metropolitan area. Results indicated that there were no significant correlations between pain, distress and the waiting room environment. It is intended that this study will provide a framework for future research in the area of chronic pain and distress in order to advance the understanding of research in the waiting area environment and the effect it may have on the patient. / Dissertation/Thesis / M.S.D. Design 2012

This investigation utilized a novel, self-help, multi-element psychological program to manage chronic low back pain. A literature review indicated that this disorder was costly and prevalent, yet a large percentage of chronic low back pain patients did not respond to traditional treatment. Recent research has demonstrated that numerous psychological difficulties have been associated with this disorder, including depression and anxiety. It was hypothesized that these psychological concomitants of chronic low back pain maintain and promote further pain, as part of a vicious cycle. Self-help treatment attempted to break this tension-pain-anxiety cycle using various stress reduction, and cognitive and behavioral management strategies.