The thesis solves mounting of Continental IO-55ON to four-seat all composite aeroplane. Weight analysis of weights carried by engine mounting was done and loads of mounting and nose gear attached directly to mounting was computed according to CS-23 regulation. Mounting was designed based on affordable information about similar aeroplanes and it was sized due to Nastran/Patran system strength analysis. Further reinforcing of fire wall, engine covers and forms for their manufacture was suggested.

No description available.

The aim of this study is to compare selected episodes of Ovid's Metamorphoses with three works of modern literature containing the theme of metamorphosis, and to follow their intertextual relations, dependency and innovation of Ovidian themes. On the basis of a comparison of the ancient and the modern text it is examined which motives remain constant during centuries and which, on the contrary, are evolving and shifting their meanings. Through the perspective of the Metamorphoses an attempt is made to interpret the works from a less usual angle. The most significant Ovidian characters that are examined in this study are Teiresias, Daphne, Hyacinth, Orpheus, Ceres, Icarus, Callisto and Io.

Les possibilités offertes par les applications en médecine des nanoparticules sont l’un des facteurs essentiels des progrès médicaux attendus pour ce XXIème siècle. Ainsi, le domaine de l’imagerie médicale est aussi touché par cette évolution technologique. Ce présent travail a consisté à élaborer des sondes théranostiques à base de nanoparticules d’oxydes de fer (SPIO) et de nanotubes de titanate (TiONts) pour l’imagerie multimodale (magnétique/nucléaire ou magnétique/optique) et possédant aussi un effet thérapeutique (hyperthermie/PDT ou radiosensibilisation/PDT).Les nanotubes de titanate de cette étude, d’une longueur moyenne d’environ 150 nm, ont été obtenus par synthèse hydrothermale selon la méthode de Kasuga. Ces nanotubes présentent un diamètre extérieur de l’ordre de 10 nm et une cavité interne de 4 nm. Les nanoparticules d’oxydes de fer ont quant à elles été synthétisées par méthode de co-précipitation "Massart". Ces nanoparticules d’oxydes de fer de structure spinelle possèdent des cristallites de 9 nm de diamètre et présentent un comportement superparamagnétique mis en évidence par des mesures FC/ZFC. Pour préparer ces nanoparticules à recevoir des molécules d’intérêt biologique, deux ligands possédant des fonctions organiques plus réactives (APTES : NH2 et PHA : COOH) ont été greffés à la surface de ces deux types de nanoparticules. La présence de l'un ou l'autre a été mise en évidence par différentes techniques d’analyses (XPS, IR, zêtamétrie). La quantité de molécules greffées a été déterminé par ATG, elle est dans tous les cas d’environ 5 molécules/nm2. Dans un premier temps, les nanotubes de titanate ont été fonctionnalisés par un agent macrocyclique (0,2 DOTA/nm2). Après radiomarquage à l’indium 111, les TiONts – DOTA[In] ont été injectés dans des souris Swiss mâle nude pour connaître leur biodistribution en imagerie SPECT/CT. Les images obtenues et le comptage de la radioactivité dans chaque organe ont montré qu’au bout d’une heure, les nanotubes se situent dans les poumons et dans l’urine. Ensuite, les nanotubes sont progressivement éliminés pour n’être plus présents que dans les urines à 24 heures. Ces mêmes agents chélatants ont été greffés à la surface des SPIO pour la création de sondes multimodales IRM/SPECT ou IRM/TEP. En parallèle de cette étude, un fluorophore (phtalocyanine de zinc, ZnPc) a été greffé à la surface des nanoparticules. Le nanohybride SPIO – Pc synthétisé possède les propriétés requises pour être une sonde utilisable en imagerie bimodale IRM/IO grâce à sa longueur d’émission vers 670 nm et sa relaxivité de l’ordre de 70 L.mmolFe3O4-1.s-1. De plus, les nanohybrides ont été fonctionnalisés par du PEG pour les rendre furtifs, biocompatibles et stables. La toxicité de certains de ces nanohybrides a été évaluée avec le modèle in vivo zebrafish. Les nanohybrides étudiés n’ont pas présenté de toxicité, n’ont pas perturbé l’éclosion et n’ont pas provoqué de malformations sur les larves des zebrafish. / The new implementations of nanoparticles in the medical field are one of the essential factors of the medical progress expected at the beginning of this XXIst century. Thus, the domain of the medical imaging is also affected by this technological evolution. This work consisted in developing theranostic probes with iron oxides nanoparticles (SPIO) and titanate nanotubes (TiONts) for multimodal imaging (magnetic/nuclear or magnetic/optical) and also possessing a therapeutic effect (hyperthermia/PDT or radiosensitization/PDT).The titanate nanotubes of this study have an average length of about 150 nm and were obtained by Kasuga's hydrothermal synthesis. These nanotubes present an outside diameter of about 10 nm and an intern cavity of 4 nm. On the other hand, iron oxides nanoparticles were synthesized by soft chemistry ("Massart" method). These spinel-like iron oxides nanoparticles have a crystallite size of 9 nm in diameter and exhibit a superparamagnetic behavior which was highlighted by FC / ZFC measurements.To get these nanoparticles ready to receive molecules of biological interest, two linkers of more reactive organic functions (APTES: NH2 or PHA: COOH) were grafted to the surface of these two types of nanoparticles. Their presence was shown by different techniques (XPS, IR, UV-vis). The amount of grafted linkers was determined by TGA and in all cases this amount is close to 5 molecules/nm2. First, titanate nanotubes were coated by a macrocyclic chelating agent (0.2 DOTA/nm2). After radiolabelling with indium 111, the TiONts – DOTA[In] nanohybrids were injected in Swiss nude mice and observed by SPECT/CT imaging to characterize their biodistribution. The SPECT/CT images and the radioactivity measured in each organ showed that after one hour, nanotubes are located in lungs and in urine. Then, the nanotubes are gradually eliminated and are only found in urines after 24 hours. The same macrocyclic agent was grafted to the SPIO’s surface for the creation of multimodal probes MRI/SPECT or MRI/PET. Alongside this study, a fluorophore (Zinc phthalocyanine) was also grafted to the surface of nanoparticles. The synthesized SPIO – Pc nanohybrid has the required properties of bimodal imaging MRI/OI probe thanks to his emission wavelength around 670 nm and its relaxivity is about 70 L.mmolFe3O4-1.s-1. Furthermore, nanohybrids were coated by PEG to make them stealth, biocompatible and stable.In this study, the toxicity of most nanohybrids was evaluated by the in vivo zebrafish model. The studied nanohybrids did not present any toxicity, hatching disruption or malformation on zebrafish larvae.

After the democratic election of 1994, a new and integrated education system was developed in South Africa in accordance with international trends and the stipulations of the South African Bill of Rights with regard to equality, human dignity, basic education and equal access to education. According to the inclusive education system, learners with learning and developmental barriers should be accommodated within the mainstream of education. In order for inclusive education to succeed, a network of support was developed on departmental, provincial, district and school level. At school level, the school-based support team is directly responsible for supporting learners with learning and developmental barriers, educators and parents/caregivers. The effectiveness of these school-based support teams will, eventually, determine the quality of this inclusive education approach. The question which guided this research, is: How effectively does the school-based support team fullfil its function in the teaching and learning of learners with learning and developmental barriers within the framework of inclusive education? A qualitative research design was chosen which is exploratory, descriptive and explanatory. After an initial literature study in which international and national trends in this field were investigated, five primary mainstream schools were selected in the Western Cape according to certain criteria. A pilot study was conducted in another school to refine data collection strategies. Information was then gathered in the five schools by means of structured questionnaires, individual and focus group interviews, field notes and the study of appropriate documents. In order to evaluate these teams, eleven criteria were designed to serve collectively as an evaluation instrument. The effectiveness of the school-based support teams in the five schools were subsequently assessed and placed in various categories according to a conceptual framework. It was found that the school-based support teams function relatively effectively in most areas. The composition of the teams is effective. However, the teams function ineffectively with regard to the orientation and training of their members, as well as of the teachers and parents/caregivers of learners with learning and developmental barriers / Thesis (PhD (Educational Psychology))--University of Pretoria, 2008. / Educational Psychology / unrestricted

The objective of this study was to investigate how well the academic performance of the Industrial and Organisational Psychology master’s students at a research institution can be predicted through psychometric measures. A non-experimental design was used in this empirical study. The sample consisted of one hundred and thirty-three IO Psychology master’s students over a five-year period. The secondary data for this research originated from the students completing the Graduate Verify Ability tests as well as the Occupational Personality Questionnaire, which are psychometric measures that form part of the selection. Both psychometric measures load onto the Person Job Match competencies. A theoretical relationship could be found between the Ability tests and academic success as well as the PJM competencies that included weighted scores from both psychometric measures. The empirical relationships, therefore, proved that the ability tests have the strongest predictive ability for academic success. / Industrial and Organisational Psychology / M. Com. (Industrial and Organisational Psychology)

L’encéphalomyélite myalgique (EM) est une maladie complexe, multi-systémique et débilitante, dont l’étiologie est inconnue. D’une personne atteinte d’encéphalomyélite myalgique (PAEM) à l’autre, les symptômes varient en fréquence et en sévérité créant ainsi une grande hétérogénéité clinique entre les individus. Un sous-groupe de PAEM vivent des épisodes d’intolérance orthostatique (IO) ou vivent avec une comorbidité de syndrome de tachycardie orthostatique posturale (POTS), deux conditions qui sont mal comprises. Le malaise après-effort (PEM), un des symptômes phare de l’EM, survient après une activité physique ou mentale minimale. Le malaise après-effort entraîne une dégradation générale de l’état de l’individu, peut entraîner une exacerbation des autres symptômes et va durer de plusieurs heures à plusieurs jours. Chez les individus souffrant de POTS ou d’IO, le malaise après-effort peut déclencher des épisodes d’intolérance orthostatique. Le gène SLC6A2 codant pour le transporteur de norépinephrine NET a été identifié comme potentiel mécanisme dans pathophysiologie du POTS, tout comme les protéines impliquées dans la vasodilatation, comme la thrombospondine-1 (TSP-1). Notre laboratoire a identifié un panel de onze microARN (miARN) exprimés différentiellement chez les PAEM. Parmi ceux-ci, le miR-150-5p a comme cible prédite SLC6A2. Notre hypothèse était qu’une plus grande expression du miR-150-5p après un effort ou qu’une chute de thrombospondine-1 pourrait induire une vasodilatation soudaine contribuant aux symptômes d’IO ou de POTS. Nous avons mesuré les niveaux plasmatiques du miR-150-5p et de TSP-1 avant (T0) et après (T90) l’induction du malaise après-effort chez des PAEM avec POTS/IO (n = 20), chez des PAEM sans POTS/IO (n = 117) et chez des témoins sédentaires associés pour le sexe et l’âge (n = 48). Nous avons démontré que les sujets atteints de POTS/IO avaient des niveau plus importants du miR-150-5p et des symptômes plus sévères. Finalement, nous avons également utilisé la veste intelligente Hexoskin (Carré Technologies Inc., Montreal, Qué., Canada) pour suivre un sous-groupe d’individus (n = 10) sur une plus longue période après l’induction du malaise après-effort. Avec cet outil, nous avons pu monitorer les symptômes au quotidien, permettant un meilleur suivi clinique de ces patients. Ce projet de maîtrise a permis une meilleure compréhension de la pathophysiologie de l’EM et de celle du POTS. / Myalgic encephalomyelitis (ME) is a complex chronic disease with debilitating smyptoms and unknown etiology. Symptoms vary in frequency and severity from a person with ME (PwME) to another, thus creating a highly clinically heterogeneous patient population. Some PwME also experience orthostatic intolerance (OI) episodes or live with a comorbidity of postural orthostatic tachycardia syndrome (POTS), two conditions that are not well understood. Post-exertional malaise (PEM) causes patients to experience a worsening of their symptoms following an effort, whether it be physical or mental. PEM can last from a few hours to several days. In PwME with POTS/OI, PEM can trigger orthostatic intolerance episodes. SLC6A2 is a gene coding for the norepinephrine transporter NET. Its contribution to the POTS pathophysiology has been mentioned several times in literature. A biochemical milieu prone to vasodilation was also reported as a contributing element to POTS pathophysiology. Recently, our laboratory published an article identifying a panel of eleven microRNAs (miRNAs) differentially expressed in PwME. Among these miRNAs, miR-150-5p has been predicted to target SLC6A2. Our hypothesis was that higher expression of miR-150-5p following an effort or a decrease in circulating thrombospondin-1 (TSP-1) inducing vasodilation could contribute to POTS/OI symptoms. We measured circulating levels of miR-150-5p and TSP-1 before (T0) and after (T90) PEM induction in PwME (n = 117), PwME with POTS/OI (n = 20) and age and sex matched sedentary controls (n = 48). We demonstrated that PwME with POTS/OI have higher levels of miR-150-5p at both T0 and T90, while also having more severe symptoms. Furthermore, we used the connected vest Hexoskin (Carré Technologies Inc., Montreal, Qué., Canada) to follow a subgroup (n = 10) of patients for a longer period following PEM induction. With this tool, we were able to monitor symptoms on a daily basis, allowing better clinical follow-up. Overall, this project allowed better understanding of ME and POTS’ pathophysiology.

Syftet med studien är att presentera ett designkoncept för publika diskussioner på nätet med målet att uppnå djupare diskussioner och minska mängden information overload. Arbetet använder metoden Concept Driven Interaction Design (CDID) som går ut på att skapa ett designkoncept utifrån flera olika teorier som appliceras genom interaktionsdesign. Ett designkoncept innehåller tre delar: ett namn, ett syfte och huvudprinciper. CDID innehåller sju steg som arbetet är utformat efter: 1.      Concept Generation – Summeras i en tabell som jämför diskussioner i forum (med flera antagande) och diskussioner med hjälp av metoden Philosophy for Children (P4C), samt annan teori. 2.      Concept Exploration – Åtta olika designaspekter identifieras utifrån jämförelsetabellen. 3.      Internal Concept Critique – Designaspekterna jämförs med två snarlika diskussionsformat. 4.      Design of Artifacts – Designkoncept version 1 skapas. 5.      External Design Critique – Intervjuer utförs för att undersöka intervjupersonerna generella erfarenheter av online diskussioner, testar antagandena från jämförelsetabellen och ge direkt feedback på första versionen av designkonceptet. 6.      Concept Revisited – Ändringar görs baserat på intervjumaterial och direkt feedback. 7.      Concept Contextualization – Designkonceptet kopplas tillbaka till litteraturen. Studien resulterar i ett designkoncept kallat CoFramer och stödjer dessa huvudprinciper som ställs i kontrast till material som identifierats genom intervjuerna: Tabell 1: CoFramers huvudprinciper och faktorer från intervjuer om diskussioner på forum. CoFramers huvudprinciper | Från intervjuer om diskussioner på forum Strukturerad början och slut | Diskussion utan tydligt slut Begränsat antal deltagare | Stor mängd deltagare Minimum antal deltagare | Många inaktiva åskådare Explicita deltagare | Lite information om deltagare Gemensamma förutsättningar | Otydlighet kring deltagares förutsättningar Begränsad informationstäthet per inlägg | Långa inlägg och/eller snabba inlägg Den röda tråden och parallella trådar | Oftast parallella trådar Aktiv samtalsledare | Outredda missförstånd Studien indikerar på att CoFramer bör resultera i mer strukturerade diskussioner och som utsätter användaren för en lägre mängd information overload och mindre grounding cost jämfört med vad som vanligtvis uppstår i publika diskussioner online. / The focus of this essay is to develop a design concept for online public discussions with deep discussions and low information overload. The method used is Concept Driven Interaction Design (CDID) which involves constructing a design concept by applying a variety of theories in tangible interaction design. A design concept has three basic parts: a name, high-level goals and outlines generic principles. CDID includes seven steps which is used in this work: 1.      Concept Generation – Formatted into a table that compare forum discussion (with several hypothesis) compared to discussions with the method Philosophy for Children (P4C) and other theories. 2.      Concept Exploration – Eight distinct design aspects are identified from the comparison table. 3.      Internal Concept Critique – The design aspects are compared to three similar discussion formats. 4.      Design of Artifacts – Design concept version 1 is created. 5.      External Design Critique – Interviews are conducted to explore their general experience of online discussions, investigate the hypothesis from the comparison table and to seek direct feedback on the first draft of the design concept. 6.      Concept Revisited – Changes are made to the design concept based on the interview material and the direct feedback. 7.      Concept Contextualization – The design concept is related to the original literature. The result of the study is a design concept named CoFramer. CoFramer’s generic principles are summarized and contrasted against factors identified from the interview material in this table: Tabell 2: CoFramer’s generic principles and interviews about online discussions. CoFramer’s generic principles | From interview material on forum discussion Organized start and ending | Discussions without clear ending Limited number of participants | Large number of participants Minimum number of participants | Large number of inactive spectators Explicit participants | Low information about participants Common conditions | Vagueness in participants conditions Limited information density per post | Long posts and/or fast posts The red thread and parallel threads | Often parallel threads Active facilitator | Unresolved misunderstandings The study indicates that CoFramer would create more structured discussions with a lower amount of information overload and less grounding cost compared what normally arise in public online discussions.