Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / It was objectified in this dissertation to analyze the distribution of the stress and displacements in the bone-implant interface, using the finite element method. The implants had been analyzed in two distinct situations: put directly in the two bone layers, cortical and trabecular, simulating the situation of immediate load, previous to osseointegration, and with the implants involved by a denser bone layer simulating the occurrence of the osseointegration. The geometry of the bone layers was obtained by means of computerized cat scan and the format of the implants and the prosthetic components had been supplied by the Neodent (Curitiba, Brazil). The variables analysed had been: geometry of the implants (cylindrical and taper), abutment (internal hexagon and morse taper) and the positioning of the implants in relation to the alveolar bone boards (buccaly and palatine). With this, 16 groups of analysis were formed, for which bidimensional models of the alveolus of extration of an upper central incisor had been constructed, simultaneously with the geometry of the implants, for the numerical simulation. The results of bigger relevance had been: the Von Mises stresses, principal stress (maximum and minimum) and the shear stresses, as well as the relative displacements presented by the bone-implant structure. Through the analyses, one concluded that different implant geometries adjust themselves better to each situation (immediate load and osseointegrated implant), and that the Titamax CM implant, of cylindrical format with prosthetic connection, morse taper, in palatine position was the one that best adapted itself. The found values can lead to a better understanding of the biomechanics around the implants. Despite of being a preliminary study, the work supplies subsidies for the accomplishment of future researches, since the methodology used can be applied in a variety of similar cases found in the Implantology. / Objetivou-se nesta dissertação analisar a distribuição das tensões e deslocamentos na interface osso-implante, utilizando o método dos elementos finitos. Os implantes foram analisados em duas situações distintas: assentados diretamente nas duas camadas ósseas, cortical e trabecular, simulando a situação de carga imediata, anterior a osseointegração; e com os implantes envolvidos por uma camada óssea mais densa simulando a ocorrência da osseointegração. A geometria das camadas ósseas foi obtida por meio de tomografia computadorizada. O formato dos implantes e componentes protéticos foram fornecidos pela Neodent (Curitiba, Brasil). As variáveis analisadas foram: geometria dos implantes (cilíndrico e cônico), pilar (hexágono interno e cone morse) e o posicionamento dos implantes em relação às tábuas ósseas alveolares (vestibularizado e palatinizado). Com isto formou-se 16 grupos de análise, para os quais foram construídos modelos bidimensionais do alvéolo de extração de um incisivo central superior, conjuntamente com as geometrias dos implantes, para a simulação numérica. Os resultados de maior relevância foram: as tensões de Von Mises, tensões principais (máximas e mínimas) e as tensões cisalhantes, bem como os deslocamentos relativos apresentados pela estrutura osso-implante. Por meio das análises concluiu-se que, diferentes geometrias de implantes se ajustam melhor a cada situação (carga imediata e implante osseointegrado), e que o implante Titamax CM, de formato cilíndrico com conexão protética cone morse posicionado palatinizado, foi o que melhor adaptou-se. Os valores encontrados podem levar a um melhor entendimento da biomecânica ao redor dos implantes. Apesar de ser um estudo preliminar, o trabalho realizado fornece subsidio para a realização de pesquisas futuras, pois a metodologia utilizada pode ser empregada em uma variedade de casos similares encontrados na implantodontia. / Mestre em Engenharia Mecânica

Os traumatismos nas dentições decíduas e permanentes e suas estruturas de suporte ocorrem com grande freqüência em crianças e diversos estudos epidemiológicos identificaram a escola como um local com alta freqüência destes tipos de traumatismos. Desta forma, é comum que o atendimento imediato da criança seja realizado pelos professores, os quais podem ser responsáveis pelo insucesso do tratamento da lesão pelo cirurgião-dentista, caso haja falhas no manuseio dos dentes traumatizados no local do acidente. Assim, esta pesquisa teve como objetivo verificar os conhecimentos de professores do Ensino Fundamental sobre procedimentos de urgência nos traumatismos alvéolo-dentários com especial enfoque sobre as avulsões, seu reimplante e acondicionamento e avaliar a necessidade de informações adicionais sobre traumatismos destes profissionais. As escolas pertencentes ao bairro Butantã foram convidadas a participar deste estudo que consistiu na aplicação de um questionário com perguntas referentes a: dados pessoais como gênero, idade, experiência profissional, nível de instrução, disciplina lecionada, treinamento em primeiros socorros, assim como perguntas relativas a noções de atendimento ao aluno vítima de traumatismo alvéolo-dentário referente a simulações de um caso de fratura dental e um outro de avulsão dental, procedimentos de urgência em casos de avulsão e a medicação utilizada. Os resultados obtidos a partir de 177 questionários retornados pelos professores foram tabulados, apurados e analisados estatisticamente através do software Epi Info 6. Os resultados demonstraram que os professores apresentaram um número maior de respostas corretas nas questões que envolveram especificamente fratura dental, tempo e local de procura por atendimento profissional, sendo que para as questões relativas ao reimplante e acondicionamento de dentes avulsionados as respostas foram inadequadas. Verificou-se que a responsabilidade pelo atendimento urgencial de um aluno vítima de algum acidente, segundo a amostra consultada, deveria ficar a cargo de toda a equipe escolar e não somente ao professor. Finalmente, constatou-se que os professores da amostra possuem pouco conhecimento sobre o tema, o que, associado à falta de treinamento, pode torná-los despreparados para solucionar adequadamente eventuais acidentes que envolvam os escolares em traumas dento-alveolares. Esta limitação de conhecimentos quanto aos procedimentos adequados relacionados aos traumatismos alvéolo-dentários, principalmente as avulsões, reforça a necessidade de educação para o público leigo não apenas no que se refere ao atendimento inicial de um traumatismo alvéolo-dentário, mas também no que se concerne às medidas preventivas. / Several epidemiological studies have reported that schoolchildren are prone to suffer accidents in their school environment that could cause dental trauma to either primary or permanent teeth and the corresponding supporting structures. These children normally receive first aid care from teachers who are not adequately trained to handle traumatized teeth at the site of the accident and therefore could lessen the chances of success of the dentist in treating the injury. The aim of our study was to evaluate the degree of information that elementary school teachers have when dealing with emergency procedures concerning replant and storage of avulsed teeth and consider the importance of offering further education on dental trauma. Our method consisted in applying a questionnaire to elementary schoolteachers at the district of Butanta, São Paulo. Questions included information concerning personal data such as: gender, age, professional experience, level of education, discipline taught, and first aid training, mainly in relation to dental trauma. Also included were a case simulations of dental fractures, a case of dental avulsion and questions referring to emergency procedures on dental avulsion and medication. The results obtained from the 177 questionnaires answered by the teachers were tabulated, confirmed and statistically analyzed by the software Epi Info 6. Questions involving dental fracture and time and place for pursuing professional help received the most correct answers whereas the ones referring to replant and storage of avulsed teeth were unsatisfactory. According to investigated sample not only the teachers, but also all the school personnel should be responsible for adequate emergency management of students suffering accidents, including dental trauma. The teachers involved in our study demonstrated very little knowledge on the subject and therefore their lack of adequate practical training results in inadequate management of situations involving accidents leading to dento-alveolar traumas, mainly avulsions. We reinforce the need of education of lay people dealing with the initial management of a dental trauma as well as orientation on preventive measures.

A proposta neste estudo foi avaliar as alterações da densidade ótica do osso alveolar perimplantar cervical em controle longitudinal, por meio de radiografias periapicais digitalizadas de dez pacientes, nos quais foram instalados seis implantes na maxila submetidos à função oclusal imediata, mediante a instalação de uma prótese fixa 24 horas após a cirurgia. Todos os pacientes foram avaliados clinicamente, com exames da análise da freqüência de ressonância, além de controle radiográfico. Foi utilizada a técnica radiográfica intrabucal do parale lismo, com cone longo, sendo que o feixe de raios X incidiu perpendicularmente ao longo eixo do implante. Os controles radiográficos foram realizados na instalação da prótese, após 6 meses e após 12 meses. As radiografias obtidas foram então capturadas por uma câmera de vídeo (preto e branco) por meio de um microscópio ótico (40 vezes de aumento). Devido à ampliação utilizada, os implantes tiveram suas imagens digitalizadas em 2 etapas (metade direita e metade esquerda), sendo consideradas como amostras independentes. Após a sobreposição de um gabarito sobre a imagem, com a finalidade padronizar as áreas a serem estudadas, foram analisadas as densidades óticas na área de interesse osso + implante e na área de controle implante (onde não é esperada alteração) por meio do software ImageLab. Para a correção de possíveis variações na densidade da radiografia e projeção geométrica oriundas da metodologia empregada, foi utilizada uma equação matemática para validar a análise dos dados obtidos. Os resultados mostraram que ocorreu variação percentual da densidade ótica na área de interesse (osso + implante) nos primeiros seis meses (T2) com diminuição de aproximadamente 5% para o lado direito e diminuição de aproximadamente 6% para o lado esquerdo em relação às radiografias iniciais (T1) e após doze meses, a diminuição da densidade ótica estabilizou-se, não sendo encontradas alterações estatisticamente significantes em relação ao período correspondente entre T2 (seis meses) e T3 (doze meses). Os resultados da análise digital das radiografias periapicais demonstraram coincidência com os resultados da análise da freqüência de ressonância e exame clínico dos implantes e demonstraram um aspecto compatível com o sucesso dos implantes osteointegrados com função imediata na maxila. / The aim in this study was the evaluation of the variations of the perimplantar optical bone density at the cervical region in a longitudinal control, by the use of digitized radiographs of ten patients, who received six implants installed in the maxilla and submitted to immediate occlusion function, through fixed prosthesis installed 24 hours after the surgery. All the patients were observed in clinical control, with resonance frequency analysis and also radiographic control. It was performed a intraoral radiograph using the paralleling technique, with the long cone and the beam of x-ray aimed perpendicular to the long axis of the implant. The radiographic controls were done at the time of the installation of the prosthesis, after six months and after twelve months after the first control. The obtained radiographs were captured by a black and white video camera by an optical microscope (40 times of magnification). Due to the utilized magnification, the implants have their images digitized in two steps: half right and half left, and they were considered as independent samples. After the superimposition of a standardized pattern, to help the standardization of the areas of the study, it was analyzed the optical density at the areas of interest bone + implant and at areas of control bone (where it is not hope changes) through the software ImageLab. To correct possible variations of the effect of the absence of standardization of the geometric projection and the radiographic density, it was realized a mathematic equation and it was obtained a correction factor of density in order to compensate. The results sho wed that there were percentage variation of the optical density at the area of interest (bone + implant) at six months (T2) showed a decreased of about 5% for the right side and showed a decreased of about 6% for the left side when analyzed the first control and after twelve months no significant statistical difference was observed between the T2 period (six months) and T3 period (twelve months). The results of digital analysis from the intraoral radiographs showed as the same as the results of resonance frequency analysis and the clinic examination of the implants and showed a success of implants installed in the maxilla with immediate occlusion function.

Esta pesquisa teve como objetivos, avaliar a influência da técnica de Calatonia sobre as condições clínicas (pressão arterial sistêmica, frequências cardíaca e respiratória, temperatura corpórea axilar, saturação de oxigênio), dor e índices de Aldrete e Kroulik e de Ramsay, dos pacientes no período pós-operatório imediato. Foi realizado um estudo randomizado, com cento e dezesseis pacientes, submetidos à cirurgia de colecistectomia por videolaparoscopia, divididos em grupos experimental (58 pacientes) e placebo (58 pacientes). Os pacientes do grupo experimental receberam a técnica da Calatonia, e os do placebo foram submetidos apenas a toques não intencionais. Os resultados mostraram que os pacientes dos grupos placebo e experimental foram considerados homogêneos quanto às variáveis: sexo, idade, ASA (Physical Status Classification), tempo de procedimento cirúrgico e de permanência na Sala de Recuperação Pós-Anestésica (SRPA). Não se observaram diferenças estatisticamente significantes, entre os grupos, quanto à avaliação clínica da escala de Aldrete e Kroulik e escala de sedação de Ramsay e aos parâmetros clínicos, com exceção da temperatura corpórea axilar, que apresentou diferença estatística significante, no momento de admissão na SRPA. Quanto à dor os pacientes do grupo experimental, apresentaram resultados significativos, podendo-se inferir que o relaxamento proporcionado pela técnica de Calatonia trouxe o alívio do quadro doloroso e, sendo assim, pode-se considerá-la como uma terapia adjuvante para o alívio da dor. Conclui-se que a aplicação da Calatonia pode atuar como recurso complementar à assistência no período pós-operatório imediato, priorizando a subjetividade do ser humano, sem se distanciar da realidade da instituição. Por se tratar de uma proposta inovadora, com a aplicação da técnica no período pós-operatório imediato, acredita-se que a Calatonia contribuirá para uma melhora do quadro clínico, proporcionando o bem-estar físico e emocional do paciente, além de resgatar a assistência humanizada e individualizada. / This research had as objective to evaluate the influence of the technique of Calatonia on the clinical conditions (systemic arterial pressure, cardiac and respiratory frequencies, axillary corporal temperature, oxygen saturation), pain and indexes of Aldrete and Kroulik and that of Ramsay, of the patients in the immediate postoperative period; A randomized study was carried through, with one hundred and sixteen patients, submitted to the Videolaparoscopic cholecystectomy surgery, divided in groups: experimental (58 patients) and placebo (58 patients). The patients of the experimental group received the Calatonia technique, and those of placebo group were submitted only to non-intentional touchs. The results showed that the patients of the groups placebo and experimental were considered homogeneous in which refers to the variables: sex, age, ASA (Physical Status Classification), in the Postanaesthetic Recovery Room (SRPA) it was not observed any significant statistical differences, between the groups, as to the clinical evaluation of the Aldrete and Kroulik scale as well as the sedation scale of Ramsay and the clinical parameters, except the axillary corporal temperature, which presented significant statistical difference, at the moment of the admission at the SRPA. As to the pain, the patients of the experimental group presented significant results, being it possible to infer that the relaxation proportionated by the technique of Calatonia brought the relief of the painful status and, thus, it can be considered as an adjuvant therapy for the relief of the pain. So, it can be concluded that the application of the Calatonia can act as complementary resource to the assistance in the immediate postoperative period, prioritizing the subjectivity of the human being, without leaving the reality of the institution. Since it is a innovative proposal, with the application of the technique in the immediate postoperative period, it is given credit that the Calatonia will contribute for an improvement of the clinical situation, providing the physical and emotional patient well-being, besides rescuing the human and individualized assistance as well.

Avaliou-se o comportamento biomecânico, quanto à área de estabilidade protética, extensão de cantilever e estabilidade por análise freqüência de ressonância (AFR); parâmetros clínicos: índice de placa (IP), índice de sangramento (IS), supuração, distância da plataforma do implante-margem da mucosa (DPM), profundidade de sondagem (PS), nível de inserção (NI), sangramento à sondagem (SS), largura (LM), espessura (EM) da mucosa e análise radiográfica, em dois sistemas de reabilitações implanto-suportadas. Foram instalados 104 implantes, submetidos à ativação imediata, em 26 pacientes, divididos em dois grupos: A (n= 16, All-on-4®-Nobel Biocare) e B (n=10, Neopronto®-Neodent). As próteses foram instaladas em tempo médio de 32h. (T0), e controles realizados em seis (T6), doze (T12) e 24 meses (T24). Como resultado, a taxa de sucesso foi de 100% para o grupo A e 90% para o grupo B para implantes e próteses. Diferenças significantes (p<0,05) foram apresentadas entre o cantilever posterior 10,96mm e 18,81mm e o braço de resistência (BR) 13,87mm e 5,50mm, respectivamente para os grupos A e B. A área de estabilidade, no grupo A foi de 373,5mm2 e no B de 112,8mm2; a média da AFR (em ISQ) do grupo A T0= 68,62; T6=64,40; T12=67,07; T24=66,53 e do grupo B T0= 68,37; T6=66,29; T12=67,09; T24=67,10, com diferenças (p<0,05) entre os tempos (grupo A) e posição dos implantes (grupo B). O IP no grupo A=1,0 e 0,7; grupo B=0,6 e 0,9, o IS (0,7), supuração (ausente) e SS (presença) no grupo A=50% e 37,9%; grupo B=70,1 e 52,1%, no controle de 12 e 24 meses, não mostraram diferenças estatísticas entre os grupos. As médias (em mm) da LM para o grupo A (2,05 e 2,21) e B (2,29 e 2,40) e EM grupo A (1,53 e 1,56) e B (1,31 e 1,43), DPM do grupo A (2,54e 2,52) e B (0,18mm e -0,12mm), PS grupo A (3,52 e 3,52) e B (3,52 e 4,0), NI grupo A (0,98 e 0,99) e B (3,05 e 3,57) e perda óssea grupo A (0,45mm e 0,23mm ) grupo B(0,66mm e 0,22mm), respectivamente para 12 e 24 meses, apresentaram diferenças estatísticas entre os controles. Concluindo-se que 1- O grupo A apresentou área de estabilidade e extensão de cantilever anterior e posterior, com comportamento biomecânico mais favorável do que no grupo B; 2- A estabilidade primária e secundária (AFR) foi diferente entre os tempos (grupo A) e posição dos implantes (grupo B), mas semelhantes entre os grupos; 3- Os parâmetros clínicos de índice de placa, sangramento marginal, supuração, profundidade de sondagem (exceto para os períodos de controle no grupo B), sangramento a sondagem, largura e espessura de mucosa ceratinizada foram semelhantes entre os grupos; 4- A distância da plataforma do implante-margem da mucosa foi maior no grupo A e o nível de inserção foi maior no grupo B; 5- A perda na altura da crista óssea foi semelhante entre os grupos; 6- A perda óssea foi menor nos implantes anteriores do que nos posteriores, nos grupos. / Two implant-supported rehabilitation systems were evaluated considering their biomechanical behavior, the area of prosthetic stability, cantilever extensions, stability using resonance frequency analysis (RFA) and clinical parameters, such as: modified plaque index (PI), modified bleeding index (BI), suppuration, distance between the implant shoulder and the mucosal margin (DIM), probing pocket depth (PD), probing attachment level (PAL), bleeding on probing (BP), thickness (TM) width (WM) of keratinized mucosa and radiographic analysis. One hundred and four implants had been installed in twenty six patients, submitted to immediate loading and divided into two groups: A (n=16, All-on-4®-Nobel Biocare) e B (n=10, Neopronto®-Neodent). The prosthesis had been installed in average time of 32h (T0), and controls made in (T6), 12 (T12) and 24 months (T24). As result, the success rate was 100% for the group A and 90% for the group B for both implants and prosthesis. Significant differences (p<0,05) 10,96mm and 18,81mm had been presented between posterior cantilever and the resistance arm (RA) 13,87mm and 5,50mm, respectively for the groups A and B. The stability area, in the group A was of 373,5mm2 and in B of 112,8mm2; the average of RFA (in ISQ) of the group A T0= 68,62; T6=64,40; T12=67,07; T24=66,53 and of the group B T0= 68,37; T6=66,29; T12=67,09; T24=67,10, with differences (p<0,05) between the periods (Group A) and implant position (Group B). The PI in group A was of 1,0 and 0,7 and 0,6 and 0,9 for group B, o BI (0,7), suppuration (absent), DP (presence) in group A=50% and 37,9%; group B=70,1 and 52,1%, in the control of 12 and 24 months, did not present statistical differences between the groups. The average (in mm) of WM for the group A (2,05 and 2,21) and B (2,29 and 2,40) and TM group A (1,53 and 1,56) and B (1,31 and 1,43), DIM of group A (2,54 and 2,52) and B (0,18mm and -0,12mm), DP group.

Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-07-14T20:09:10Z No. of bitstreams: 1 davisonschaefferdeoliveira.pdf: 558469 bytes, checksum: 9eda3fec8b950cdea0aa550e9b18ee1e (MD5) / Approved for entry into archive by Diamantino Mayra (mayra.diamantino@ufjf.edu.br) on 2016-07-19T15:48:26Z (GMT) No. of bitstreams: 1 davisonschaefferdeoliveira.pdf: 558469 bytes, checksum: 9eda3fec8b950cdea0aa550e9b18ee1e (MD5) / Made available in DSpace on 2016-07-19T15:48:26Z (GMT). No. of bitstreams: 1 davisonschaefferdeoliveira.pdf: 558469 bytes, checksum: 9eda3fec8b950cdea0aa550e9b18ee1e (MD5) Previous issue date: 2011-03-02 / CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico / A presente pesquisa tem por objetivo investigar a filosofia da religião de Friedrich D. E. Schleiermacher. Pretende-se apresentar sua teoria geral acerca da religião, tendo por fio condutor dois conceitos fundamentais: o conceito de sentimento e autoconsciência imediata. A fim de cumprir a tarefa desta pesquisa, e, ao mesmo tempo, considerando a amplitude da obra de Schleiermacher, dois de seus principais escritos se apresentam como referenciais teórico-fundamentais: Über die Religion (1799) e Glaubenslehre (1830). Desse modo, a partir de uma análise descritiva e sistemática destas duas obras, objetiva-se expor de que maneira Schleiermacher elabora sua concepção de religião como uma dimensão constitutiva da subjetividade humana. / The aim of this research is to investigate the Friedrich D. E. Schleiermacher’s philosophy of religion. It seeks to present his general theory about religion focussing on two basics concepts: feeling and immediate self-consciousness. In order to accomplish this task, keeping in mind the sheer size of the Schleiermacher’s work, two of his major writings are presented as crucial theoretical sources: Über die Religion (1799) and Glaubenslehre (1830). Thus the goal of this research is to expose on the basis of a descriptive and systematic analysis of these two works how Schleiermacher elaborates his conception of religion as a constitutive dimension of human subjectivity.

La population qui constitue l’objet d’intérêt de la thèse est la communauté polonaise, fixée sur le territoire français depuis l’entre-deux-guerres, dans leur forte majorité ayant statut des « travailleurs étrangers ». L’objectif de la thèse est l’analyse de la situation et de l’histoire de la communauté polonaise en France dans les dimensions sociale, politique, culturelle et dans les aspects précis choisis. L’autre objectif est la présentation de la population polonaise comme étant exemplaire de la situation des immigrés en France dans l’immédiat après-guerre. Les deux premiers chapitres apportent l’analyse des notions employées, la présentation du contexte démographique, économique et politique de la France au lendemain de la Seconde Guerre mondiale et de la genèse de la communauté immigré polonaise en France. Les deux chapitres suivants constituent les études précises de cette communauté dans l’immédiat après-guerre, par l’analyse de la situation, du statut et des changements au sein de l’immigration polonaise, ensuite des conflits politiques intérieures au sein de cette communauté – tout cela dans le contexte du rapatriement, organisé à l’époque par les autorités polonaises de Varsovie. Le dernier chapitre constitue l’étude de l’évolution des phénomènes de l’enseignement polonais, de l’aumônerie polonaise et de la fameuse vie associative des Polonais en France. En bref, la thèse présente divers aspects du processus de l’intégration progressive de la communauté immigrée polonaise à la société d’accueil, accélérée par les années d’hostilités et le contexte particulier de l’immédiat après-guerre. / The object oh the following thesis is the Polish community living in France from the interwar period, in the majority consisting of laborers who owned the status of travailleur étranger – “foreign worker”. The aim of this dissertation is the analysis of the situation and the history of the Polish community in France in the following dimensions: social, political and cultural and in chosen detailed aspects. What is more, the aim of the thesis is a presentation of Polish community as an example of situation of immigrants in France in the years following Second World War. The first two chapters present the analysis of notions frequently used and demographic, economical and political context in France of that time, at last the presentation of the genesis of the Polish community in France. Next two chapters constitute detailed study of this community in the chosen period, through the analysis of its situation, legal status and social changes, as well as internal political conflicts. This is described, taking into consideration, repatriation of the Poles from France, organized by the Polish government in Warsaw. The last chapter constitutes the study of evolution of the Polish education phenomenon, Polish priesthood and well-known activity of Polish associations. To sum up, in the thesis are presented the diverse aspects of the progressive process of the integration of the Polish immigrants in France which was accelerated by the War and the specific context of the first years after the Liberation.

The author conceives the presented thesis partly as a case study, when she illustrates different aspects of sanctions on a practical example defined for the purposes of this work. Furthermore, she maps different kinds of aspects related to analyzed sanctions. The thesis is divided into the introduction, five main chapters and the conclusion. Overall, the work has two parts, the first one is the introduction and the first chapter, second part consists of the definition of the practical example, from which it derives, then the second, the third, the fourth and the fifth chapter and the conclusion. In a brief introduction, the author has a think about the meaning of general terms such an obligation, a legal obligation and sanctions for breaching duties. The first chapter contains a definition of terms that are analyzed further in the work. Furthermore, the chapter continues with the general definition of sanctions, particularly from the perspective of legal theory, including the attempt on the author's own definition of sanctions. As an introduction to another part of the work is defined a model case from which the work (partially processed as a case study) further unfolds. The basis of this case is a breach of the obligation to pay out employees wages. On this basis, in the text are more fully...

Les archives audiovisuelles renferment, indubitablement, des éléments importants du patrimoine culturel. Mais, bien que les archives audiovisuelles existent voilà plus de 50 ans et ne cessent de se multiplier de jour en jour, leur définition précise, tout de même, est objet à polémique ou, à tout le moins, est très ambigüe. En plus, vu la fréquence et l’intervalle de leur réutilisation, force est de se demander s’il n’y a pas l’émergence d’une nouvelle forme d’archives : les « archives immédiates ». Il faut aussi se demander si le « genre archives » n’est pas en train de s’ériger comme un genre nouveau. Par ailleurs, ces archives sont, partout, particulièrement en Afrique noire, menacées d’extinction. D’une part, les variétés des supports analogiques et, de l’autre, les multiples formats numériques pour les sauvegarder et les réutiliser, demeurent un dilemme. Pourtant, l’impérieuse nécessité de rendre accessibles et compréhensibles, en tout temps et en tout lieu, les fonds patrimoniaux audiovisuels accumulés, s’impose. Un patrimoine, pour être pérenne, doit traverser les âges, dépasser les contingences techniques et se faire approprier sous son éclairage le plus net. Cette thèse étudie les solutions pour pérenniser les archives audiovisuelles et permettre de comprendre et de retrouver le contexte dans lequel elles ont été produites. Effectivement, leur contextualisation, notamment pour ce qui est relatif au patrimoine culturel particulier africain, commande une indexation très spécifique, comparativement aux archives écrites traditionnelles. Ceci révèle une démarche documentaire singulière pour perpétuer, faire circuler et revaloriser le patrimoine culturel audiovisuel africain dans le contexte de la mondialisation de l’information documentaire audiovisuelle. Le bon usage des archives audiovisuelles africaines doit se conformer à ces conditions indispensables pour être un contrepoids qui pèse dans l’échange globalisé de l’information audiovisuelle. / Audiovisual archives undoubtedly contain important elements of cultural heritage. But while audiovisual archives exist here over 50 years and are continuing to multiply by the day, their precise definition, nonetheless, is subject to controversy, or at least very ambiguous. In addition, due to the frequency and interval of reuse, it is reasonable to wonder whether there is not the birth of new form of archives: the "immediate archives". Moreover, these archives are everywhere, especially in Black Africa, threatened with extinction. On one hand, the varieties of analog media and, on the other, the multiple digital formats to save and reuse them remain a dilemma. Also, the problem of preserving and reusing these collections remains an ongoing concern. Yet it is imperative to make accessible and understandable, at all times and in all places, the accumulated audiovisual patrimony funds, regardless of the media on which this heritage is recorded. To be sustainable and appropriate under its clearest signification, a heritage must, through the ages, exceed the technical contingencies and of interpretation. This thesis studies the solutions to make audiovisual archives sustainable and to allow to understand and to find out the context in which they were produced. Indeed, their contextualization, including what relates especially to the African cultural heritage, reveals to be a very specific indexing control, compared to traditional written records. This unveils a singular documentary approach in order to perpetuate and assure circulation and upgrading the African audiovisual cultural heritage in the context of the globalization of audiovisual documentary information. The proper use of African audiovisual archives must comply with these conditions needed to be a counterweight that hangs in the globalized exchange of audiovisual information.

The advent of prostate-specific antigen (PSA) testing and increased patient awareness has led to patients being diagnosed with prostate cancer at an earlier stage and a younger age than previously. Adjuvant hormonal therapy to radiotherapy or prostatectomy has been shown to reduce the risk of tumour progression, and in some studies survival benefits have been demonstrated. The non-steroidal antiandrogen bicalutamide (‘Casodex’) has undergone extensive evaluation and is currently undergoing clinical trials as immediate therapy, either alone or as adjuvant to treatment of curative intent in patients with localized or locally advanced disease. Data from the first analysis of one of the studies in the Early Prostate Cancer (EPC) programme involving 3,603 patients have shown that, after a median follow-up of 2.6 years, the risk of prostate cancer progression was significantly reduced (by 43%) in patients receiving bicalutamide 150 mg compared with those receiving standard care alone (HR 0.57; 95% CI 0.48, 0.69; p ≪ 0.0001). The risk of PSA progression was also significantly reduced (by 63%). At this stage the survival data are still immature. Side effects of bicalutamide were mostly gynaecomastia and breast pain, which is consistent with its pharmacology. Overall withdrawal rates were similar in the bicalutamide 150 mg and standard care alone groups. In the bicalutamide 150 mg group, withdrawals were mainly due to side effects, whereas in the group receiving standard care alone, withdrawals were mainly due to disease progression. The programme is ongoing, and survival data are awaited. / Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.