The main goal of the submitted thesis is evaluation of the Part-ORA regulations and requirements which are puts on the training organisations. In the first part, the discussion about the organisation responsible for issuing of the Part-ORA regulations is made. There are described particular parts of the regulation. The second part deals with problems which are connected with acceptation of regulations requirements. There is a description of the most significant differences between the JAR-FCL regulations and Part-ORA regulations. Next part describes the scope of the requirements in particular. In the third part there is made a guidance material to creation safety management system of the organisation.

This thesis deals with construction of rotary-nut ball screw. In the first chapter technical research at the current state of linear positioning systems and matters associated with them is listed. The next chapter treats of basic concepts and designs referring to ball screws. Further on the boundary between rotary ball screw and rotary- nut ball screw is described. On basis of restrictions and selected criterions solution of one size of rotary – nut ball screw with all the calculations.

This thesis focuses on the analysis and the use of the register of voluntary associations of municipalities. The theoretical part of the work is focused on defining the cooperation of municipalities, namely voluntary associations of municipalities, and funding op-portunities for public investment. The practical part deals with the analysis of public associations of municipalities of the South Moravian region, which was part of a specific research. They are then matched funding options selected project independent community through the voluntary association of municipalities.

La centralisation des données patients au sein de répertoires numériques soulève des problématiques d’interopérabilité avec les différents systèmes d’information médicaux tels que ceux utilisés en clinique, à la pharmacie ou dans les laboratoires d’analyse. Les instances de santé publique, en charge de développer et de déployer ces dossiers, recommandent l’utilisation de standards pour structurer (syntaxe) et coder l’information (sémantique). Pour les données du diagnostic in vitro (DIV) deux standards sémantiques sont largement préconisés : - la terminologie LOINC® (Logical Observation Identifier Names and Codes) pour représenter les tests de laboratoire ;- l’ontologie SNOMED CT® (Systematized Nomenclature Of MEDicine Clinical Terms) pour exprimer les résultats observés.Ce travail de thèse s’articule autour des problématiques d’interopérabilité sémantique en microbiologie clinique avec deux axes principaux : Comment aligner un Système Organisé de Connaissances du DIV en microbiologie avec l’ontologie SNOMED CT® ? Pour répondre à cet objectif j’ai pris le parti dans mon travail de thèse de développer des méthodologies d’alignement adaptées aux données du diagnostic in vitro plutôt que de proposer une méthode spécifique à l’ontologie SNOMED CT®. Les méthodes usuelles pour l’alignement d’ontologies ont été évaluées sur un alignement de référence entreLOINC® et SNOMED CT®. Les plus pertinentes sont implémentées dans une librairie R, qui sert de point de départ pour créer de nouveaux alignements au sein de bioMérieux. Quels sont les bénéfices et limites d’une représentation formelle des connaissances du DIV ? Pour répondre à cet objectif je me suis intéressée à la formalisation du couple <Test—Résultat>(Observation) au sein d’un compte-rendu de laboratoire. J’ai proposé un formalisme logique pour représenter les tests de la terminologie LOINC® qui a permis de montrer les bénéfices d’une représentation ontologique pour classer et requêter les tests. Dans un second temps, j’ai formalisé un patron d’observations compatible avec l’ontologie SNOMED CT® et aligné sur lesconcepts de la top-ontologie BioTopLite2. Enfin, le patron d’observation a été évaluée afin d’être utilisé au sein des systèmes d’aide à la décision en microbiologie clinique. Pour résumer, ma thèse s’inscrit dans une dynamique de partage et réutilisation des données patients. Les problématiques d’interopérabilité sémantique et de formalisation des connaissances dans le domaine du diagnostic in vitro freinent aujourd’hui encore le développement de systèmes experts. Mes travaux de recherche ont permis de lever certains de ces verrous et pourront être réutilisés dans de nouveaux systèmes intelligents en microbiologie clinique afin de surveiller par exemple l’émergence de bactéries multi-résistantes, et adapter en conséquence des thérapies antibiotiques. / The centralization of patient data in different digital repositories raises issues of interoperability with the different medical information systems, such as those used in clinics, pharmacies or in medical laboratories. The public health authorities, charged with developing and implementing these repositories, recommend the use of standards to structure (syntax) and encode (semantic) health information. For data from in vitro diagnostics (IVD) two standards are recommended: - the LOINC® terminology (Logical Observation Identifier Names and Codes) to represent laboratory tests;- the SNOMED CT® ontology (Systematized Nomenclature Of MEDicine Clinical Terms) to express the observed results.This thesis focuses on the semantic interoperability problems in clinical microbiology with two major axes: How can an IVD Knowledge Organization System be aligned with SNOMED CT®? To answer this, I opted for the development of alignment methodologies adapted to the in vitro diagnostic data rather than proposing a specific method for the SNOMED CT®. The common alignment methods are evaluated on a gold standard alignment between LOINC® and SNOMED CT®. Themost appropriate are implemented in an R library which serves as a starting point to create new alignments at bioMérieux.What are the advantages and limits of a formal representation of DIV knowledge? To answer this, I looked into the formalization of the couple ‘test-result’ (observation) in a laboratory report. I proposed a logical formalization to represent the LOINC® terminology and I demonstrated the advantages of an ontological representation to sort and query laboratory tests. As a second step, I formalized an observation pattern compatible with the SNOMED CT® ontology and aligned onthe concept of the top-ontology BioTopLite2. Finally, the observation pattern was evaluated in order to be used within clinical microbiology expert systems. To resume, my thesis addresses some issues on IVD patient data share and reuse. At present, the problems of semantic interoperability and knowledge formalization in the field of in vitro diagnostics hampers the development of expert systems. My research has enabled some of the obstacles to be raised and could be used in new intelligent clinical microbiology systems, for example in order to be able to monitor the emergence of multi resistant bacteria and consequently adapt antibiotic therapies.

Les recherches menées dans cette étude se situent dans le cadre de l’analyse du volontarisme étatique dans l’accélération du processus d’égalité entre les femmes et les hommes. Notre postulat de départ est que l'émancipation de la femme en Tunisie émane d'une volonté politique impulsée depuis le haut par le pouvoir tunisien par le biais d’une réforme juridique. Nous défendons l’idée selon laquelle le rapport entre l’État et la question féminine en Tunisie demeure indissociable. La libération des Tunisiennes ayant été portée par le dirigisme étatique dans le cadre d’un régime de type autoritaire, il nous a semblé important de chercher à comprendre et à expliquer les paradoxes de ce projet autoritaire de modernisation ainsi que les dynamiques sociales et les tensions qui en résultent. Notre réflexion s’est constituée autour d’un deuxième axe, à savoir le rapport complexe qu’entretient le régime autoritaire tunisien avec la question féminine. Nous avons ainsi émis l’hypothèse que les raisons de l’engagement du régime dépassent la simple émancipation des femmes ou l’instauration d’une égalité entre les sexes pour s’inscrire dans une logique de contrôle, de répression, et dans un rapport clientéliste. Cette partie constitue une critique du féminisme d’État en Tunisie et de la manière avec laquelle il monopolise la question féminine. Nous en sommes venus à analyser la monopolisation de la cause féminine par le régime tunisien ainsi que les réactions et/ou les mobilisations des femmes et leur opposition à cette politique féministe autoritaire. / The research conducted in this study is part of the analysis of state voluntarism in accelerating the process of equality between women and men. Our starting postulate is that the emancipation of women in Tunisia comes from a political will, driven from the top by the Tunisian power through a legal reform. We are defending the idea that the link between the state and the women's issue in Tunisia remains inseparable. The liberation of Tunisian women has been directed by state as part of an authoritarian regime, therefore we thought it was important trying to understand and explain the paradoxes of this authoritarian project of modernization along with social dynamics and tensions resulting from it. Our reflection was built around a second approach, that is the complex link between the Tunisian authoritarian regime and the women’s issue. We thus hypothesized that the reasons for the regime's commitment go over the simple emancipation of women or the establishment of gender equality in order to fit into a logic of control, repression, and in a clientelist relation. This part forms a criticism of the state feminism and of the way it monopolizes the women’s issue. We finally analyzed how the Tunisian regime monopolize the women's cause and we studied the reactions and / or mobilizations of women as well as their opposition to this authoritarian feminist policy.

Bakgrund: Barnmorskor upplever att rotationsarbete och kontinuitet i arbetet leder till en god vård, bredare kunskap samt att det uppskattas av patienter. Barnmorskorna känner sig mer välmående i sin arbetssituation. Det leder även till en dubbel kompetens hos barnmorskorna. Syfte: Syftet med studien var att beskriva barnmorskors upplevelse av att arbeta roterande mellan mödrahälsovård och förlossningsvård. Metod: En kvalitativ intervjustudie där semistrukturerade intervjuer med åtta deltagande barnmorskor arbetande i mellansverige utfördes. En kvalitativ innehållsanalys utfördes vilken resulterade i fyra kategorier samt nio subkategorier. Resultat: Barnmorskornas upplevelser av att arbeta roterande beskrevs som ett omväxlande och givande arbete som gav glädje och tillfredsställelse, trots att det var arbetsamt. Samtidigt var det en utmanande uppgift då de behövde hålla sig uppdaterade på två arbetsplatser, få ihop tidboken på barnmorskemottagningen och bibehålla kompetensen på förlossningsavdelningen. Arbetsplatserna skiljde sig åt vilket var med fördelar och nackdelar. En viktig grundsten i arbetet var kollegialt stöd, och att ha en hemarbetsplats istället för två upplevdes positivt. Rotationsarbete ur patientsynvinkel ansåg barnmorskorna vara uteslutande positivt då de kunde ge ett utökat stöd till de födande vilket var en vinst för både barnmorskan och patienten. Slutsats: Trots att det kräver extra arbete från barnmorskorna är upplevelserna av att arbeta roterande övervägande positiva både ur barnmorskans eget perspektiv samt deras beskrivning av respons från patienterna. Det finns relevans för att genomföra ytterligare forskning inom området genom att intervjua en större grupp med barnmorskor. / Background: Midwives experience that working rotationally and with continuity leads to a quality of good care, bigger knowledge and the care is valued by patients. This also leads to a double competency for the midwives. Aim: The aim of the study was to describe midwives’ experience of working rotation between antenatal care and perinatal care. Method: A qualitative interview study with semi structured interviews were conducted, with eight participating midwives working in the central Sweden. An analysis was conducted, resulting in four categories and nine subcategories. Result: The midwives’ experiences of working rotationally were described as a varied and rewarding job that brought joy and satisfaction, even though the work was trying. The work was a challenging task, they needed to be updated at two workplaces, make sure the patients were being cared for at the maternity clinic and maintain the expertise at the maternity ward. The workplaces differed, which was advantageous and disadvantageous. An important cornerstone for the work was collegiate support and having one instead of two working places. From the patients’ point of view the rotationally work by the midwives was positive as they could provide increased support for childbearing women, which was beneficial for the midwives and the patient. Conclusion: Although it requires extra work from the midwives, the experience of working with rotation is mostly positive both from the midwife’s own perspective as well as their description of the patient’s response. There is relevance for conducting further research in the field by interviewing a larger group of midwives.

Orientador: Rosa Maria Manzoni / Resumo: Trata-se de uma pesquisa de intervenção pedagógica que objetiva identificar as possíveis transferências e adaptações operadas nas capacidades de linguagem e na mobilização de conceitos ao se produzirem gêneros de agrupamentos distintos (um diário e um abaixo-assinado). Fundamentam teoricamente a pesquisa tanto a Psicologia Histórico-Cultural, por meio das contribuições sobre aprendizagem e desenvolvimento, com a noção de zona de desenvolvimento proximal, e sobre o processo de formação de conceitos espontâneos e científicos (VIGOTSKI, 1991, 2009) quanto o Interacionismo Sociodiscursivo, no qual amparamos a noção de gênero como instrumento promotor de aprendizagem e desenvolvimento (SCHNEUWLY, 1994, 2004) e de onde extraímos as categorias de análise textual (BRONCKART, 2009) que permitem observar as capacidades de linguagem dos aprendizes (DOLZ, PASQUIER, BRONCKART, 1993). A produção dos dados da pesquisa foi metodologicamente orientada pela Engenharia didática, por meio do procedimento das Sequências didáticas (DOLZ, NOVERRAZ e SCHNEUWLY, 2004) e da modelização didática dos gêneros (DE PIETRO e SCHNEUWLY, 2003; SCHNEUWLY e DOLZ, 2004). Na preparação da pesquisa, foram feitas adaptações nas práticas sociais de referência dos gêneros diário íntimo e pessoal e abaixo-assinado a fim de torná-los objetos de ensino; posteriormente estes gêneros foram inseridos em uma sequência didática desenvolvida com estudantes concluintes do ensino médio prevendo a produção de um diário, no iníci... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: It is a research of pedagogical intervention that aims to identify the possible transfers and adaptations operated in the language abilities and in the mobilization of concepts when producing genres of different groups (a diary and a petition). Theoretical research is based on both Historical-Cultural Psychology, through contributions on learning and development, with the notion of a zone of proximal development, and on the process of forming spontaneous and scientific concepts (VIGOTSKI, 1991, 2009) and Interactionism Sociodiscursive, in which we support the notion of gender as an instrument that promotes learning and development (SCHNEUWLY, 1994, 2004) and from which we extract the categories of textual analysis (BRONCKART, 2009) that allow observing the language skills of learners (DOLZ, PASQUIER , BRONCKART, 1993). The production of the research data was methodologically oriented by Didactic Engineering, through the Didactic Sequences procedure (DOLZ, NOVERRAZ and SCHNEUWLY, 2004) and the didactic modeling of the genres (DE PIETRO and SCHNEUWLY, 2003; SCHNEUWLY and DOLZ, 2004). Na preparation of the research, adaptations were made to the social practices of reference of the intimate and personal daily and petitioned genres in order to make them objects of teaching; later these genres were inserted in a didactic sequence developed with high school students predicting the production of a diary, at the beginning, and that of a petition, at the end. The confrontation between ... (Complete abstract click electronic access below) / Résumé: C'est une recherche d'intervention pédagogique qui vise à identifier les possibles transferts et adaptations opérés dans les capacités langagières et dans la mobilisation des concepts lors de la production de genres de différents groupes (journal intime et pétition). La recherche théorique est basée à la fois sur la psychologie historique et culturelle, à travers des contributions sur l'apprentissage et le développement, avec la notion de zone de développement proximal, et sur le processus de formation de concepts spontanés et scientifiques (VIGOTSKI, 1991, 2009) et l'interactionnisme Sociodiscursive, dans laquelle nous soutenons la notion de genre comme instrument favorisant l'apprentissage et le développement (SCHNEUWLY, 1994, 2004) et dont nous extrayons les catégories d'analyses textuelles (BRONCKART, 2009) qui permettent d'observer les compétences linguistiques des apprenants (DOLZ, PASQUIER, BRONCKART, 1993). La production des données de recherche a été orientée méthodologiquement par l'ingénierie didactique, à travers la procédure des séquences didactiques (DOLZ, NOVERRAZ et SCHNEUWLY, 2004) et la modélisation didactique des genres (DE PIETRO et SCHNEUWLY, 2003; SCHNEUWLY et DOLZ, 2004). Na préparation de la recherche, des adaptations ont été apportées aux pratiques sociales de référence des genres intimes et personnels quotidiens et pétitionnés afin d'en faire des objets d'enseignement; plus tard ces genres ont été insérés dans une séquence didactique développée avec ... (Résumé complet accès életronique ci-dessous) / Mestre

L’analyse de mesures longitudinales –appelées trajectoires– est de plus en plus fréquente en recherche médicale. L’un des intérêts de cette analyse est d’identifier des groupes d’individus ayant des trajectoires similaires. La classification obtenue peut être utilisée pour mieux comprendre l’hétérogénéité des évolutions entre individus. La classification peut être déterminée à partir d’un modèle pour lequel les trajectoires des individus correspondent à la trajectoire du groupe auquel ils sont affectés. L’objectif de la thèse est de développer une extension de ce modèle de classification standard permettant une meilleure prise en compte de la variabilité au sein des groupes, (i) variabilité des valeurs du marqueur (variance résiduelle) et (ii) variabilité des profils d’évolution (variance inter-individuelle). Deux modèles de classification sont développés : 1) un premier modèle qui prend en compte une variance résiduelle au sein de chaque groupe variable d’un groupe à l’autre, et 2) un deuxième modèle qui prend en compte une variabilité des trajectoires au sein des groupes au lieu de de prédire la même trajectoire pour tous les individus d’un même groupe, variabilité qui peut être identique ou variable d’un groupe à l’autre. L’intérêt de ces deux modèles a été montré par des travaux de simulations et par des applications cliniques. Globalement, lorsque le nombre de mesures et de trajectoires est suffisant, ces modèles donnent de meilleures classifications que celles du modèle de classification standard. Par ailleurs, en dehors de plans expérimentaux très contrôlés, les deux sources de variabilité sont inhérentes à la recherche en santé. Ces modèles sont donc très pertinents d’un point de vue clinique / The analysis of longitudinal measures –called trajectories– is more and more frequent in clinical research. One of the interests of this analysis is to identify groups of individuals with similar trajectories. The obtained classification is used to understand and explore the heterogeneity of trajectories among subjects. The classification can be performed by a model that predicts the same trajectory for all the subjects that are classified in the same group. The objective of this thesis is to develop an extension to the standard classification model that gives greater consideration to the variability within groups, (i) the variability of marker values (residual variance), and (ii) the variability of the individual trajectories inside a group (between-individual variance). Two classification models were developed: 1) a first model that allows unequal residual variance across groups, and 2) a second model that takes into account a between-individual variance within each group instead of predicting the same trajectory for all subjects in the same group, a variance that can be equal or unequal across groups. The interest of these two models has been studied by simulations and through clinical applications. Overall, when the number of trajectories and measurements per trajectory is sufficient, these models gives better classification compared to the standard classification model. Moreover, except for highly controlled experimental designs, the two sources of variability are inherent to research in health. Therefore, these models are very relevant from a clinical point of view.

Orientador: Fernando Andrade Fernandes / Resumo: Considerando que o delito de corrupção é favorecido pelo mundo globalizado, em que as atividades econômicas encontram-se interligadas numa rede de interdependência dos mercados, gerando uma maior complexidade da sociedade e consequente relativização de valores, das regras morais e jurídicas, o presente trabalho tem como objetivo realizar uma análise do problema pela ótica do Sistema Integral de Direito Penal, considerando-se o entendimento de que apenas nessa perspectiva mais abrangente será possível uma melhor compreensão do fenômeno frente à mencionada complexidade. Registre-se, inicialmente, a hipótese de que se trata de uma manifestação do fenômeno delitivo, que possui raízes em uma perspectiva criminológica a qual passou a enfatizar a relevância penal também de alguns fatos realizados por determinados sujeitos de elevado status social (powerfull), com destaque para certas práticas no mundo dos negócios. Considerando-se a elevada danosidade social destas práticas e a complexidade operativa da sua execução, com alcance muitas vezes multinacional, será avaliada a opção, já efetivada, de criação de uma política criminal internacional sobre o problema, por meio de documentos de alcance transnacional, que expressem valores comuns neste contexto mais amplo, sob pena de atos de deslealdade concorrencial serem severamente punidos em um determinado país e, simplesmente, não configurarem crime em outros, desequilibrando as relações econômicas estabelecidas na esfera transnacional, ... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Considering that the crime of corruption is fomented by the globalized world, in which economic activities are interconnected in a network of interdependence of the markets, generating a greater complexity of society and consequent relativization of values, of moral and juridical rules, the present article has as an objective to carry out an analysis of the problem from the perspective of the Comprehensive Criminal Law System, considering the understanding that only in this more comprehensive perspective will a better understanding of the phenomenon be possible in the face of this complexity. The hypothesis is initially that this is a manifestation of the delirium phenomenon that has roots in a criminological perspective that began to emphasize the criminal relevance also of some facts carried out by certain subjects of high social status (powerfull) for certain practices in the business world. Considering the high social damage of these practices and the operational complexity of their execution, which is often multinational in scope, the option of creating an international criminal policy on the problem will be evaluated through documents of transnational scope, common values ​​in this broader context, under penalty of acts of competitive disloyalty being severely punished in one country, and simply not setting up crime in others, unbalancing the economic relations established in the transnational sphere, by the disproportion of the legal burdens that permeate such relation... (Complete abstract click electronic access below) / Mestre

Mit dem Projekt ID4BM wurde eine hochschulübergreifende Lehrkooperation umgesetzt. Es wurden zwei Seminare in allen Phasen – von der Wissensbereitstellung über die Wissensanwendung bis hin zur Bewertung – miteinander verzahnt. Technologische Basis war die Lernplattform OPAL. Verwendete Methoden waren projektbasiertes Lernen, Flipped Classroom, Virtual Classroom, Gruppenarbeit, eTutoring, Gruppencoaching und Peer Review. Dieser Beitrag liefert Einblicke in die Konzeption der Lehrveranstaltung und die Evaluationsergebnisse.