• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 69
  • 15
  • 10
  • 9
  • 8
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • Tagged with
  • 151
  • 151
  • 40
  • 24
  • 23
  • 17
  • 16
  • 16
  • 15
  • 14
  • 13
  • 12
  • 12
  • 12
  • 12
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
141

Entwicklung eines neuen digitalen Menschmodells für den Einsatz in kleinen und mittleren Unternehmen

Spitzhirn, Michael, Bullinger, Angelika C. January 2013 (has links)
Der Einsatz von digitalen Menschmodellen erlaubt neben einer frühzeitigen ergonomischen Analyse die Gestaltung von Arbeitsprozessen und stellt ein hilfreiches Werkzeug in der Produkt- und Prozessgestaltung dar. Im Rahmen dieses Beitrages soll auf ausgewählte Schwerpunkte der Entwicklung des digitalen Menschmodells „The Smart Virtual Worker“ eingegangen werden. Das Forschungsprojekt soll einen Beitrag zur Lösung, der mit dem demografischen Wandel der Gesellschaft einhergehenden Herausforderungen leisten. Die daraus resultierenden Forschungsschwerpunkte liegen insbesondere in der Einbeziehung von Alterungs- und psychischen Faktoren in die Bewegungsgenerierung des Menschmodells und der Modellierung von Umweltbedingungen. In Umsetzung des Projektes wurde ein erstes Arbeitsszenario erarbeitet, auf dessen Basis die vorgenannten Forschungsaufgaben interdisziplinär gelöst werden sollen.
142

Operational performance driven production system design process

Islam, Md Hasibul January 2022 (has links)
The design process of a production system referred to as the production system design process (PSDP) impacts on the operational performancethroughout the lifecycle of the production system, especially on the rampupand operation phases. Despite the impact of activities of PSDP on the operational performance, how to manage the PSDP is still a challenge for manufacturing companies. Earlier research urged to develop a systematic PSDP concerning its impact on the operational performance. This thesis aims to contribute with knowledge of how manufacturingcompanies can manage the PSDP by investigating 1) the enablers in thePSDP that impact on operational performance in ramp-up and operation phases, and 2) how the lean production concept could be adopted tomanage the activities during the PSDP. A case study was conducted in aprocess type manufacturing company, where empirical data were collectedfrom three new production line launching projects by qualitative means. This thesis identifies a set of enablers in the PSDP that potentiallyimpact the operational performance after launching the productionsystem. Empirical findings demonstrate that ensuring proper actions onthe identified enablers in the PSDP could lead to higher operationalperformance of the designed production system. These enablers rangefrom the company´s internal boundary to external vendors, requiring asystematic way to manage these diverse aspects. Adopting the lean production concept in the PSDP context, this thesis proposes a model of Lean Production System Design Process, containing 13 principles andrelevant practices. The proposed model of lean PSDP could be used as a systematic processto manage the activities in the PSDP that would ensure proper actions related to the identified enablers. Empirical findings indicate that adoptionof lean in the PSDP could result in reducing lead time of launching a new production system, and achieving fast ramp-up and desired operational performance considering sustainability aspects. Finally, this thesis demonstrates how the lean PSDP could be a means to achieve a sustainable competitive advantage based on the resource based view theoretical perspective. / Utformningsprocessen av ett produktionssystem, i denna avhandlingkallad produktionssystemets utformningsprocess (PSUP), påverkar denoperativa prestandan under hela produktionssystemets livscykel, särskilt iupprampnings- och driftsfasen. Traditionellt sett ligger fokus underutformningsprocessen på att lansera det nya produktionssystemet vidplanerad tidpunkt och enligt budget. Trots att de aktiviteter somgenomförs i utformningsprocessen påverkar den operativa prestandan idriftsfasen, ägnas ofta mindre uppmärksamhet åt designfasen än vad somvore önskvärt. Tidigare forskning har argumenterat för att utveckla ensystematisk designprocess för framtagning av produktionssystem medsyfte att nå en positiv påverkan på den operativa prestandan. Forskningen i denna avhandling bidrar till att öka kunskapen om hurPSUP kan hanteras och förbättras genom att identifiera: 1) möjliggörare i PSUP som påverkar den operativa prestandan i upprampnings- ochdriftfasen, och 2) hur lean konceptet skulle kunna användas för att hanteraaktiviteterna under PSUP. Resultatet är identifieringen av ett antal faktorer/möjliggörare iproduktionssystemets utformningsprocess (PSUP) som potentiellt kanpåverka den operativa prestandan efter lansering av produktionssystemetoch produktionsstart. Dessa möjliggörare handlar om alltifrån frånföretagets interna gränser till externa leverantörer och kräver ensystematisk procedur för att dra nytta av faktorernas potential. Genom attanvända lean även i PSUP-sammanhanget, föreslås här konceptet Lean PSUP (produktionssystemsutformningsprocess), som innehåller 13 principer och relevanta praxis. Den föreslagna modellen för lean PSUP skulle kunna användas och gestruktur till hanteringen av aktiviteterna i utformningsprocessen.Forskningen indikerar att lean inte bara kan användas i driftsfasen utanäven i utformningen av ett produktionssystem, vilket skulle kunnaresultera i bättre integration mellan olika funktioner, minska ledtiden förutformning och lansering av ett nytt produktionssystem, och uppnå snabbupprampning och önskad operativ prestanda, både avseende produktionoch hållbarhet. Slutligen visar denna avhandling hur lean PSUP kan varaett sätt att uppnå konkurrensfördelar ur ett resursbaserat teoretiskt perspektiv.
143

Проектирование технологического процесса обработки корпусной детали «Корпус адаптера» с элементами исследования средств технологического обеспечения операций в условиях автоматизированного производства : магистерская диссертация / Designing the process of processing the body parts "Adapter housing" with elements of research of technological support tools for operations in automated production conditions

Пупырева, А. С., Pupyreva, A. S. January 2019 (has links)
Работа выполнена на основании данных АО «НПО автоматики». Дипломный проект состоит из трех частей: Технологической, которая включает: описание конструкции детали; определение типа производства; разработку концепции механической обработки детали; выбор вида заготовки и метода её получения; конструирование заготовки и определение общих припусков на обработку; составление планов обработки каждой поверхности в соответствии с этапами обработки; разработку маршрута, включающего назначение базовых поверхностей, выбор станочного оборудования и технологической оснастки; моделирование эскизов на каждую операцию; определение операционных допусков и припусков на обрабатываемые поверхности; определение операционных размеров на обрабатываемые поверхности; выбор режимов обработки; определение норм времени на каждую операцию; оформление рабочей технологической документации. Конструкторской, которая включает: определение потребной силы закрепления (силовой расчёт); выбор и расчёт механизированного привода; точностной анализ приспособления; эскизное конструирование общего вида приспособления; проектирование контрольного приспособления; оформление рабочей конструкторской документации. Научно-исследовательской, которая включает экспериментальное исследование влияния режима резания на качество обрабатываемой поверхности из алюминиевого сплава АМг6 с последующим выводом уравнения регрессии. Графическая часть – 15 листов формата А1; Таблиц – 89; Рисунков – 44; Количество используемых источников – 19. / The work was performed on the basis of the data of JSC "NPO Automation". The graduation project consists of three parts: 1. Technological, which includes: description of the construction details; determining the type of production; development of the concept of machining parts; selection of the type of workpiece and the method of its receipt; design of the workpiece and the definition of total allowances for processing; drawing up plans for the treatment of each surface in accordance with the processing steps; development of the route, including the assignment of base surfaces, the choice of machine equipment and tooling; modeling sketches for each operation; Determination of operating tolerances and allowances for machined surfaces; determination of the operating dimensions of the treated surface; selection of processing modes; determination of time norms for each operation; registration of working technological documentation. Design, which includes: determination of the required strength of fastening (force calculation); selection and calculation of a mechanized drive; accuracy analysis of the device; conceptual design of the general form of the device; design of the control device; design of working design documentation. 3. Research, which includes an experimental study of the influence of the cutting mode on the quality of the processed surface of aluminum alloy AMg6 with the subsequent derivation of the regression equation. - Graphic part - 15 sheets of A1 format; - Tables - 89; Figures -40; The number of sources used - 18.
144

<b>Development of a Sustainability-Oriented Decision-Making Framework and Computational Tool for Energetic and Critical Material Evaluations</b>

Anusha Sivakumar (18777499) 06 June 2024 (has links)
<p dir="ltr">The modern world faces many challenges related to sustainability, including the ability to make high-level decisions using a sustainability-oriented framework, a matter of increasing importance to the United States military with respect to energetic materials (EMs). Although a few pieces - process flowsheet optimization, life cycle assessment (LCA) studies, and the use of optimization tools to identify an option - have been studied and utilized, there exists no systematic approach that combines all these pieces to create a framework that allows for holistic decision making. This is especially true with EMs, other key critical materials, and new methods of manufacture. An interconnected framework for LCA-based decision making is developed and a tool based on this framework created for use with novel materials. The interconnected framework and tool are utilized in two case studies related to the manufacture of RDX- a lab-scale, batch-mode configuration and a simplified continuous-mode configuration, to determine the optimal reaction temperature.</p>
145

A novel approach for the development of policies for socio-technical systems

Taeihagh, Araz January 2011 (has links)
The growth in the interdependence and complexity of socio-technical systems requires the development of tools and techniques to aid in the formulation of better policies. The efforts of this research focus towards developing methodologies and support tools for better policy design and formulation. In this thesis, a new framework and a systematic approach for the formulation of policies are proposed. Focus has been directed to the interactions between policy measures, inspired by concepts in process design and network analysis. Furthermore, we have developed an agent-based approach to create a virtual environment for the exploration and analysis of different configurations of policy measures in order to build policy packages and test the effects of changes and uncertainties while formulating policies. By developing systematic approaches for the formulation and analysis of policies it is possible to analyse different configuration alternatives in greater depth, examine more alternatives and decrease the time required for the overall analysis. Moreover, it is possible to provide real-time assessment and feedback to the domain experts on the effect of changes in the configurations. These efforts ultimately help in forming more effective policies with synergistic and reinforcing attributes while avoiding internal contradictions. This research constitutes the first step towards the development of a general family of computer-based systems that support the design of policies. The results from this research also demonstrate the usefulness of computational approaches in addressing the complexity inherent in the formulation of policies. As a proof of concept, the proposed framework and methodologies have been applied to the formulation of policies that deal with transportation issues and emission reduction, but can be extended to other domains.
146

Development of virtual and augmented reality environment for manufacturing / Ανάπτυξη περιβάλλοντος εικονικής και επαυξημένης πραγματικότητας για την παραγωγή

Ρέντζος, Λουκάς 07 July 2015 (has links)
Σκοπός της εργασίας είναι η μελέτη της ανάπτυξης περιβάλλοντος εικονικής και επαυξημένης πραγματικότητας για την υποστήριξη ανθρωποκεντρικών διεργασιών στον τομέα της παραγωγής. Οι τεχνολογίες εικονικής και επαυξημένης πραγματικότητας μπορούν να μειώσουν σημαντικά το χρόνο και το κόστος ανάπτυξης προϊόντων και διεργασιών στην παραγωγή. Αυτή τη στιγμή υπάρχει ένα μεγάλο χάσμα μεταξύ των συμβατικών CAD-βασιζόμενων μεθόδων και των μεθόδων προηγμένης προτυποποίησης και επικύρωσης που προσφέρει η χρήση της εικονικής και επαυξημένης πραγματικότητας. Συνεπώς, υπάρχει ανάγκη εμπλουτισμού των εικονικών περιβαλλόντων με νοημοσύνη, μέσω ενσωμάτωσης της γνώσης, επιτρέποντας την πραγματοποίηση πολύπλοκων εργασιών, μειώνοντας την ανάγκη για ανάπτυξη φυσικών πρωτοτύπων και αυξάνοντας τη δυνατότητα επαναχρησιμοποίησης. Αφενός, περιβάλλοντα επαυξημένης πραγματικότητας που βασίζονται σε σημασιολογική γνώση καθώς και νέες μέθοδοι αλληλεπίδρασης με τον χρήστη μπορούν να παρέχουν τα μέσα για την επανατοποθέτηση του ανθρώπου στην παραγωγική διαδικασία. Αφετέρου, περιβάλλοντα εικονικής πραγματικότητας σε συνδυασμό με τη σημασιολογική γνώση μπορούν να παρέχουν μεθόδους και εργαλεία που ενσωματώνουν τις 3D γεωμετρίες με τις πληροφορίες και τη γνώση, έτσι ώστε οι μηχανικοί να μπορούν αποτελεσματικά να αξιολογήσουν και να διαχειρίζονται εικονικά πρωτότυπα σε ένα εμβυθισμένο και διαδραστικό περιβάλλον. Εντός της παρούσας διατριβής, αναπτύχθηκε μια γενική VR και AR προσέγγιση βασισμένη στην ανάλυση της ανθρώπινης εργασίας και των μεθόδων χαρτογράφησης της γνώσης που υλοποιούνται σε ένα πλαίσιο εικονικής και επαυξημένης πραγματικότητας. Το πλαίσιο VR/AR έχει αναπτυχθεί για να χρησιμοποιηθεί με την προσέγγιση μεθόδου δύο σταδίων χρησιμοποιώντας προηγμένες τεχνικές αλληλεπίδρασης. Η μέθοδος και το πλαίσιο που αναπτύχθηκαν επιβεβαιώνονται μέσα από μια σειρά πραγματικών δοκιμών στην παραγωγή, τόσο της αυτοκινητοβιομηχανίας όσο και της αεροδιαστημικής βιομηχανίας. Τέλος, η αξιολόγηση των προτεινόμενων μεθόδων και του πλαισίου βασίζεται σε πραγματικές δοκιμές στη βιομηχανία με χρήση ποσοτικών δεικτών, επιβεβαιώνοντας τη βελτίωση της ροής εργασιών σε σύγκριση με τη συμβατική. / The aim of this work is to study the development of virtual and augmented reality environment for the support of human-based processes in manufacturing. Virtual and augmented reality technologies can significantly reduce the development time and cost of products and processes in manufacturing. However there is currently a big gap between the conventional CAD-based processes and the advanced prototyping and validation methods offered with the use of VR and AR technology. There is a need for the virtual environments to be enriched with intelligence through the incorporation of knowledge. This will allow for complex tasks to be carried out, thus reducing the need for an ad hoc development, while the reusability of such an environment will be increased. On the one hand, augmented reality environments based on semantic knowledge and new user interaction methods can provide the means for putting the human back in the process loop at manufacturing level. On the other hand, virtual reality environments coupled with semantic knowledge can provide methods and tools that integrate 3D geometries with information/knowledge so that engineers can effectively evaluate and manipulate virtual prototypes in an immersive and interactive environment. Within the current dissertation, a generic VR and AR approach is developed based on human task analysis and knowledge mapping methods that are implemented in a Virtual and Augmented Reality Framework. The VR/AR framework is developed to be used with the two-step method approach using advanced interaction techniques. The developed method and framework are validated through a series of real life manufacturing test cases derived from both the automotive and aerospace industrial practices. Finally, an evaluation of the proposed methods and framework is carried out, based on one of the industrial test cases using quantitative metrics, giving insight on to the improvement of the engineering workflow using the proposed work compared with the conventional physical workflow.
147

Percepción y Emoción en el Diseño de Productos. Análisis y Propuestas para su integración a las MIPYME

Jacob Dazarola, Rubén Hernán 31 March 2015 (has links)
La presente tesis aborda la temática del Diseño Industrial y los estímulos de tipo sensorial, perceptivo y emocional que las personas que utilizan los productos reciben en su experiencia de uso. Dichos estímulos, tales como el ajuste preciso en el funcionamiento de un mecanismo, la suavidad de una superficie, el ruido adecuado al cerrar una puerta, etc., se captan mediante los sentidos, se perciben y despiertan en el usuario emociones y reacciones, generando una relación con los objetos más allá del uso básico y práctico, llevando a preferirlos entre otros productos con prestaciones primarias similares, asociándolos a experiencias gratas, e incluso a evocar experiencias de vida a través de los productos que se utilizan. Este ámbito, enmarcado dentro de la disciplina del Diseño Industrial, pero también en la psicología, el marketing, la neurociencia y otras áreas, es enfocado actualmente de muy diversas formas. Así enfoques como la “Ingeniería Kansei”, el “Diseño Emocional”, el “Diseño para la Experiencia”, el “Análisis Sensorial”, son algunos modos y métodos de analizar y definir el tema, y se utilizan cada vez más en las grandes empresas. Esta tesis analiza diversos enfoques y metodologías de aplicación de este tipo de factores en el proceso de Diseño y desarrollo de productos y propone algunas herramientas adecuadas para su integración en las micro, pequeñas y medianas empresas (MiPyMEs). / Jacob Dazarola, RH. (2015). Percepción y Emoción en el Diseño de Productos. Análisis y Propuestas para su integración a las MIPYME [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/48551 / TESIS
148

Designwissen: Spezifik und Unterstützung der Akquise durch reflexive und narrative Methoden

Wölfel, Christian 24 November 2011 (has links)
Es besteht weitgehender Konsens darüber, dass Designer mit anderen Beteiligten gemeinsam bereits in frühe Phasen von Innovations- und Entwicklungsprozessen eingebunden werden müssen. Unterschiedliche Ausbildungsformen, Begriffe, Methoden und Fachkulturen von Designern und den traditionell in Technologieentwicklung involvierten Ingenieuren und Naturwissenschaftlern erschweren oder verhindern in der Praxis oftmals eine effektive Zusammenarbeit. Dieses Buch widmet sich in diesem Kontext dem bislang nur unzureichend gelösten Problem der Akquise des für den Designentwurf relevanten Wissens aus dem individuell verfügbaren Repertoire: Während diese bei Experten weitgehend intuitiv abläuft ist, stellt sie insbesondere für ingenieurwissenschaftlich vorgebildete Designnovizen ohne spezifische methodische Unterstützung ein Problem dar. Um geeignete Methoden auswählen und entwickeln zu können, wird in einem umfangreichen theoretischen Teil untersucht, wie dieses individuelle Designwissen charakterisiert ist. Auf Grundlage einer umfassenden Definition von Designwissen werden potenziell geeignete Methoden zur Unterstützung dessen Akquise dargestellt und bewertet. Reflexive Methoden auf der Basis generischer Fragelisten sowie narrative Methoden auf Basis von Nutzer-Archetypen (Personas) und normativen Szenarien bilden dabei den Schwerpunkt. Der empirische Teil umfasst vier Untersuchungen. Der tatsächliche Effekt von spezifischen reflexiven und narrativen Methoden bei der individuellen Wissensakquise wird in drei Studien mit experimentellem Charakter nachgewiesen und diskutiert. Eine vergleichende explorative Feldstudie zum Einsatz von Methoden in der beruflichen Praxis von Designern und Konstrukteuren ergänzt die Erkenntnisse und hilft, diese in einen breiteren Kontext einzuordnen.:0 VORWORT v 0.1 Danksagung v 0.2 Anmerkungen zu Form und Sprache vii 0.3 Einordnung der Arbeit in den Designforschungskontext viii 1 EINFÜHRUNG 1 1.1 Wissenschaftliche Problemlage 1 1.2 Methodisches Vorgehen 7 2 THEORETISCHE GRUNDLAGEN 9 2.1 Entwerfen 9 2.1.1 Neues Schaffen 9 2.1.2 Entwurfsdisziplinen 10 2.1.3 Innovation 21 2.1.4 Kreativität 27 2.2 Entwurfsaufgaben als Probleme 33 2.2.1 Entwurfsaufgaben als schwach strukturierte Probleme 34 2.2.2 Entwurfsaufgaben als bösartige Probleme 37 2.2.3 Entwurfsaufgaben als komplexe Probleme 39 2.2.4 Entwurfsaufgaben als wissensreiche Probleme 41 2.2.5 Entwurfsprobleme als Kategorie 43 2.2.6 Zusammenfassung 45 2.3 Entwurfsprozesse 47 2.3.1 Entwerfen als menschliches Problemlösen 47 2.3.2 Entwerfen als reflexive Konversation 53 2.3.3 Entwerfen als psychisch regulierte Tätigkeit 56 2.3.4 Vorgehensmodelle in den Disziplinen 68 2.3.5 Zusammenfassung 72 2.4 Entwurfswissen 74 2.4.1 Eingrenzung des Begriffs 74 2.4.2 Nicht-Wissen und Unsicherheit 80 2.4.3 Vor- und Erfahrungswissen 83 2.4.4 Fakten- und Episodisches Wissen, Sach- und Handlungswissen 86 2.4.5 Soziokulturelles und Alltagswissen 89 2.4.6 Implizites und explizites Wissen 92 2.4.7 Objektives, subjektives, rationales und emotionales Wissen 100 2.4.8 Zusammenfassende Definition 103 2.5 Methoden zur Wissensakquise 108 2.5.1 Markt- und Zielgruppenanalysen 109 2.5.2 Anforderungslisten 113 2.5.3 Brainstorming und Derivate 117 2.5.4 Assoziation und Analogiebildung 119 2.5.5 Entwurfszeichnen und Entwurfshandeln 122 2.5.6 Fragenbasierte Selbstreflexion 124 2.5.7 Narration 126 2.5.8 Persona 129 2.5.9 Szenario 135 2.5.10 Methodenakzeptanz in der Praxis 143 2.6 Zusammenfassung und Auswahl geeigneter Methoden 147 3 EMPIRISCHE UNTERSUCHUNGEN 151 3.1 Methodeneinsatz in frühen Entwurfsphasen in der Praxis von Designern und Konstrukteuren 154 3.1.1 Problem und Fragestellungen 154 3.1.2 Aufbau und Durchführung der Untersuchung 157 3.1.3 Ergebnisse der Untersuchung 160 3.1.4 Interpretation und Diskussion 176 3.2 Unterstützung der Anforderungsermittlung durch fragenbasierte Selbstreflexion 180 3.2.1 Problem und Fragestellungen 180 3.2.2 Aufbau und Durchführung der Untersuchung 183 3.2.3 Ergebnisse der Untersuchung 184 3.2.4 Diskussion und Interpretation 186 3.3 Unterstützung der Akquise von Designwissen durch narrative Methoden 189 3.3.1 Problem und Fragestellungen 189 3.3.2 Aufbau und Durchführung der Untersuchung 192 3.3.3 Ergebnisse der Untersuchung 197 3.3.4 Interpretation und Diskussion der Ergebnisse 205 3.4 Unterstützung der Akquise von Designwissen durch fragenbasierte Selbstreflexion 211 3.4.1 Problem und Fragestellungen 211 3.4.2 Aufbau und Durchführung der Untersuchung 212 3.4.3 Ergebnisse der Untersuchung 216 3.4.4 Interpretation und Diskussion der Ergebnisse 227 4 ZUSAMMENFASSUNG 233 5 AUSBLICK 243 6 VERZEICHNISSE 247 6.1 Literaturverzeichnis 247 6.2 Abbildungsverzeichnis 282 6.3 Tabellenverzeichnis 285 6.4 Abkürzungs- und Symbolverzeichnis 287 7 ANHANG 289
149

MiniPharm: A Miniaturized Pharmaceutical Process Development and Manufacturing Platform

Jaron ShaRard Mackey (14230133) 07 December 2022 (has links)
<p>  </p> <p>In the pharmaceutical industry, special care must be taken by companies to guarantee high quality medications that are free from byproducts and impurities. The development process involves various considerations including solvent selection, solubility screening, unit operation selection, environmental, and health impact evaluations. Traditionally, pharmaceutical manufacturing consisted of large, centralized facilities to meet pharmaceutical demands; however, there has been a recent shift toward distributed manufacturing. With distributed manufacturing platforms, rapidly changing supply chain needs can be met regionally in addition to supplying small-volume medications and personalized medicines to hospitals and pharmacies. To produce quality pharmaceuticals, distributed manufacturing platforms should integrate digital design, novel unit operations, and process analytical technology (PAT) tools for quality monitoring and control. In this dissertation, a process design and development framework is proposed and implemented for a small-scale pharmaceutical manufacturing platform: MiniPharm.</p> <p>Various approaches to process design are detailed in this dissertation, which include heuristic-based and digital or simulation-based design. For heuristic-based design, the knowledge of the researchers was utilized to provide unit operation evaluation and screening of process alternatives. In cases when unit operations were highly complex, digital or simulation-based design was utilized to conduct sensitivity analyses and simulation-based design of experiments. With the implementation of simulation-based design, material and time needs were reduced while gaining knowledge about the system. The integration of various unit operations comes with increased understanding of start-up dynamics and operational constraints. What was found to be the most successful approach was the combination of heuristics and digital design to combine researcher knowledge and experience with the information gained from process modeling and simulation to create process alternatives that utilized system dynamics to reach desired process outcomes. </p> <p>Additionally, MiniPharm was used for process model development at the small-scale. Various software packages have been made commercially available that focus on production scale; however, models for small-scale operations are not typically implemented in these packages. Models for unit operations were fit with collected experimental data to estimate model parameters for small-scale synthesis, liquid-liquid extraction, and crystallization unit operations. The models were implemented to better capture the heat and mass transfer of the milli-fluidic scale platform, which consist of unit operations housed within microchannels. MATLAB was utilized for estimation of parameters such as kinetic rate constants and overall mass transfer coefficients. These parameters were used for design space determination and process disturbance simulation. The exploration of the impact of various process parameters on quality attributes helps researchers gain a deeper understanding about the manufacturing process and helps to demonstrate how to control the process. </p> <p>An important aspect of MiniPharm is the process development progress that has been demonstrated. With the construction of a modular and reconfigurable platform, various process alternatives can now be experimentally validated. The integration of unit operations operated at a decreased scale makes MiniPharm an example of process intensification. The implementation of integrated unit operations decreases handling time of intermediates and reduces the overall footprint for manufacturing. Designed to allow for increased flexibility of operation, perfluoroalkoxy alkane (PFA) tubing was used for synthesis and purification. With PFA tubing clean in place procedures can be implemented using continuous solvent flow or the low cost, PFA tubing can be replaced. The modular nature of the platform also allows for the investigation of individual unit operations for performance evaluation. </p> <p>Finally, a novel continuous solvent switch distillation unit operation was designed and constructed along with customized reactor and crystallizers for process alternative screening for the synthesis and purification of two compounds: Diphenhydramine hydrochloride and Lomustine. Diphenhydramine hydrochloride is a low-value, high volume allergy medication commonly found in Benadryl and Lomustine is a high-value, low volume cancer medication used to treat glioblastoma and Hodgkin Lymphoma. The production of the compounds demonstrated the flexibility of the manufacturing platform to produce both a generic and a specialty medication. A versatile platform is needed for distributed manufacturing because of quickly changing supply chain needs. Overall, this dissertation successfully demonstrates the process design, development, and simulation for small-scale manufacturing.</p>
150

[pt] O DESIGN CENTRADO NO USUÁRIO NAS METODOLOGIAS ÁGEIS / [en] USER-CENTERED DESIGN IN AGILE METHODOLOGIES

LARA DA COSTA BRITO 27 April 2020 (has links)
[pt] Atualmente a pesquisa com usuários vem ganhando projeção como diferencial no desenvolvimento de produtos e serviços de interface digital, incluindo atividades que envolvem análises e observações no contexto de uso, feedbacks e avaliações. O usuário, que anteriormente era um coadjuvante, passou a ter destaque como ator principal, tornando-se peça-chave no levantamento de requisitos de um produto, em meio a um mercado competitivo em constante transformação. Pela necessidade de adequação a frequentes mudanças, a agilidade se tornou um elemento essencial, como processo alternativo de desenvolvimento. Desse modo, uma metodologia ágil foi adotada como forma de suprir a demanda pela rapidez no lançamento dos produtos, modificando profundamente a maneira como eles são estruturados e desenvolvidos, influenciados principalmente pelo fator tempo. Consequentemente, as atividades que envolvem pesquisas, ideações e avaliações tem o tempo reduzido, comprometendo a pesquisa com usuários e a aplicação dos princípios do Design Centrado no Humano. Diante disso, a presente pesquisa tem como objetivo investigar a pesquisa com usuários em consonância com a aplicação de metodologias ágeis no desenvolvimento de produtos digitais. Através da pesquisa bibliográfica, foi permitido aprofundar os conceitos sobre o design centrado no usuário, seus princípios, as metodologias associadas e seus processos, e relacioná-lo às metodologias ágeis. Mediante as entrevistas, foi possível, também, o entendimento sobre os problemas enfrentados pelos profissionais de UX na aplicação das práticas de design centrado no usuário nas organizações, gerando insumos para aplicação de um questionário online que produziu uma compreensão e análise sobre as atividades relacionadas à pesquisa com usuários na aplicação das metodologias ágeis nas empresas do mercado brasileiro. Esta pesquisa revela como os profissionais de UX aplicam as atividades que envolvem a pesquisa com usuários em conjunto com as metodologias ágeis de acordo com a amostra coletada, evidenciando as influências no desenvolvimento dos produtos segundo as características organizacionais apresentadas. / [en] Currently, user research has been gaining a projection as a differentiator in the development of digital interface products and services, including activities that involve analysis and observations in the context of use, feedback and evaluation. The user, who was previously a supporting actor, has become a major player, key in the product requirements specification, in the midst of a competitive market in constant transformation.. Due to the need to adapt to frequent changes, agility has become an essential element as an alternative development process. This way, an agile methodology was adopted as a way of supporting the demand for speed in the launch of products, thus, deeply modifying the way they are structured and developed, influenced mainly by the time factor. Consequently, activities involving research, ideation, and evaluation are time-consuming, which compromises user research and the application of the principles of User-Centered Design. Therefore, the present research aims at investigating the research with users in consonance with the application of agile methodologies in the development of digital products. The literature review, allowed us to gain in depth knowledge about user-centered design, its principles, associated methodologies and its processes, and to relate UCD to agile methodologies. Through the interviews, it was also possible to understand the issues faced by UX professionals in the application of user-centered design practices in organizations, which generated inputs for the application of an online survey, which in turn enabled both the analysis of activities related to user research in the application of agile methodologies in the Brazilian market. This research reveals how UX professionals apply the activities that involve research with users along with agile methodologies according to the collected sample, the research findings also show what influences in the development of their products according to the presented organizational characteristics.

Page generated in 0.0447 seconds